WO2002099087A3 - Cell populations for detecting neuronal targets and potential active ingredients - Google Patents

Cell populations for detecting neuronal targets and potential active ingredients Download PDF

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Publication number
WO2002099087A3
WO2002099087A3 PCT/EP2002/005968 EP0205968W WO02099087A3 WO 2002099087 A3 WO2002099087 A3 WO 2002099087A3 EP 0205968 W EP0205968 W EP 0205968W WO 02099087 A3 WO02099087 A3 WO 02099087A3
Authority
WO
WIPO (PCT)
Prior art keywords
active ingredients
receptors
cell populations
detecting
targets
Prior art date
Application number
PCT/EP2002/005968
Other languages
German (de)
French (fr)
Other versions
WO2002099087A2 (en
Inventor
Thomas Rohrmeier
Rosemarie Daig
Original Assignee
Thomas Rohrmeier
Rosemarie Daig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2001127008 external-priority patent/DE10127008C1/en
Application filed by Thomas Rohrmeier, Rosemarie Daig filed Critical Thomas Rohrmeier
Priority to EP02754603A priority Critical patent/EP1397485A2/en
Publication of WO2002099087A2 publication Critical patent/WO2002099087A2/en
Publication of WO2002099087A3 publication Critical patent/WO2002099087A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Abstract

The invention relates to populations of neuronal cells containing receptors from the group of dopamine receptors, serotonin receptors and adrenergic receptors, and not producing neurotransmitters which bind to said receptors. Said cell populations are suitable for detecting neuronal targets for analysing neuronal diseases, and for detecting potential pharmaceutical active ingredients which especially act against neuronal diseases. The invention also relates to a method for detecting such targets and active ingredients.
PCT/EP2002/005968 2001-06-05 2002-05-31 Cell populations for detecting neuronal targets and potential active ingredients WO2002099087A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP02754603A EP1397485A2 (en) 2001-06-05 2002-05-31 Cell populations for detecting neuronal targets and potential active ingredients

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2001127008 DE10127008C1 (en) 2001-06-05 2001-06-05 Population of neuronal cells containing receptors but not expressing neurotransmitters, useful e.g. in drug screening and as transplants for treating neurodegeneration
DE10127008.9 2001-06-05
DE10216045.7 2002-04-11
DE10216045 2002-04-11

Publications (2)

Publication Number Publication Date
WO2002099087A2 WO2002099087A2 (en) 2002-12-12
WO2002099087A3 true WO2002099087A3 (en) 2003-04-10

Family

ID=26009461

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/005968 WO2002099087A2 (en) 2001-06-05 2002-05-31 Cell populations for detecting neuronal targets and potential active ingredients

Country Status (2)

Country Link
EP (1) EP1397485A2 (en)
WO (1) WO2002099087A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038090A1 (en) * 1996-04-09 1997-10-16 Board Of The Trustees Of Southern Illinois University A cultural medium for maintaining neural cells in ambient atmosphere
US6040180A (en) * 1996-05-23 2000-03-21 Neuralstem Biopharmaceuticals, Ltd. In vitro generation of differentiated neurons from cultures of mammalian multipotential CNS stem cells

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175103A (en) * 1991-10-21 1992-12-29 Trustees Of University Of Pennsylvania Preparation of pure cultures of post-mitotic human neurons

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038090A1 (en) * 1996-04-09 1997-10-16 Board Of The Trustees Of Southern Illinois University A cultural medium for maintaining neural cells in ambient atmosphere
US6040180A (en) * 1996-05-23 2000-03-21 Neuralstem Biopharmaceuticals, Ltd. In vitro generation of differentiated neurons from cultures of mammalian multipotential CNS stem cells

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FISCHER HANSPETER S ET AL: "Retinoic acid treatment enhances the acetylcholine contents in the human teratocarcinoma cell line NTera-2.", REGULATORY PEPTIDES, vol. 96, no. 1-2, 2000, pages 59 - 63, XP002224281, ISSN: 0167-0115 *
MATSUOKA TOSHIYUKI ET AL: "The GABA-A receptor is expressed in human neurons derived from a teratocarcinoma cell line.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 237, no. 3, 1997, pages 719 - 723, XP002224280, ISSN: 0006-291X *
PLEASURE S J ET AL: "NTERA 2 CELLS: A HUMAN CELL LINE WHICH DISPLAYS CHARCTERISTICS EXPECTED OF A HUMAN COMMITTED NEURONAL PROGENITOR CELL", JOURNAL OF NEUROSCIENCE RESEARCH, WILEY-LISS, US, vol. 35, no. 6, 1993, pages 585 - 602, XP008001167, ISSN: 0360-4012 *
See also references of EP1397485A2 *
ZIGOVA TANJA ET AL: "Dopaminergic phenotype of hNT cells in vitro.", DEVELOPMENTAL BRAIN RESEARCH, vol. 122, no. 1, 2000, pages 87 - 90, XP002224282, ISSN: 0165-3806 *

Also Published As

Publication number Publication date
EP1397485A2 (en) 2004-03-17
WO2002099087A2 (en) 2002-12-12

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