WO2002102235A2 - Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer - Google Patents

Abstract

Described herein are genes whose expression are up-regulated or down-regulated in ovarian cancer. Related methods and compositions that can be used for diagnosis and treatment of ovarian cancer are disclosed. Also described herein are methods that can be used to identify modulators of ovarian cancer.

Description

METHODS OF DIAGNOSIS OF OVARIAN CANCER, COMPOSITIONS AND METHODS OF SCREENING FOR MODULATORS OF OVARIAN CANCER

CROSS-REFERENCES TO RELATED APPLICATIONS. This application is related to USSN 60/299,234, filed June 18, 2001 ; USSN

60/315,287, filed August 27, 2001; USSN 60/317,544, filed September 5, 2001; USSN 60/350,666, filed November 13, 2001; and USSN 60/372,246, filed April 12, 2002, each of which is incorporated herein by reference for all purposes.

FIELD OF THE INVENTION

The mvention relates to the identification of nucleic acid and protein expression profiles and nucleic acids, products, and antibodies thereto that are involved in ovarian cancer; and to the use of such expression profiles and compositions in the diagnosis, prognosis, and therapy of ovarian cancer. The invention further relates to methods for identifying and using agents and/or targets that inhibit ovarian cancer.

BACKGROUND OF THE INVENTION Ovarian cancer is the sixth most common cancer in women, accounting for 6% of all female cancers. It ranks fifth as the cause of cancer death in women. The American Cancer Society predicts that there will be about 23,100 new cases of ovarian cancer in this country in the year 2000 and about 14,000 women will die ofthe disease. Because many ovarian cancers cannot be detected early in their development, they account for a disproportionate number of fatal cancers, being responsible for almost half the deaths from cancer ofthe female genital tract; more deaths than any other reproductive organ cancer. Most patients with epithelial ovarian cancer, the predominant form, are asymptomatic in early-stage disease and usually present with stage III or IV disease. Their five-year survival is less than 25%, with lower survival among African- American women. The minority of patients discovered with early-stage disease have a five-year survival rate of 80%-90%. See, Parker, et. al.. (1997) "Cancer Statistics, 1997" CA Cancer J. Clin. 47:5-27. In the absence of a family history of ovarian cancer, lifetime risk of ovarian cancer is

1/70. Risk factors include familial cancer syndromes (risk of up to 82% by age 70 in women with hereditary breast/ovarian syndrome); family history (1.4% lifetime risk with no affected relatives, 5% with one affected relative, 7% with two affected relatives; Kerlikowske, et.al. (1992) Obstet. Gynecol. 80:700-707); nulliparity; advancing age; obesity; personal history of breast, endometrial, or colorectal cancer; fewer pregnancies; or older age (>35 years) at first pregnancy. However, 95% of all ovarian cancers occur in women without risk factors. Use of hormonal contraceptives, oophorectomy, and tubal sterilization reduce risk of ovarian cancer (Kerlikowske, et. al. (1992) Obstet. Gvnecol. 80:700-707; Grimes (1992) Am J. Obstet. Gvnecol. 166:1950-1954; Hankinson, et. al. (1993) JAMA 270:2813-2818); however, even bilateral oophorectomy may not be completely effective in preventing ovarian cancer. Treatment of ovarian cancer consists largely of surgical oophorectomy, anti-hormone therapy, and/or chemotherapy. Although many ovarian cancer patients are effectively treated, the current therapies can all induce serious side effects which diminish quality of life. Deciding on a particular course of treatment is typically based on a variety of prognostic parameters and markers (Fitzgibbons, et al. (2000) Arch. Pathol. Lab. Med. 124:966-978; Hamilton and Piccart (2000) Ann. Oncol. 11 -.641-663), including genetic predisposition markers BRCA-1 and BRCA-2 (Robson (2000) J. Clin. Oncol. 18:113sup-l 18sup).

The identification of novel therapeutic targets and diagnostic markers is essential for improving the current treatment of ovarian cancer patients. Recent advances in molecular medicine have increased the interest in tumor-specific cell surface antigens that could serve as targets for various immunotherapeutic or small molecule strategies. Antigens suitable for immunotherapeutic strategies should be highly expressed in cancer tissues and ideally not expressed in normal adult tissues. Expression in tissues that are dispensable for life, however, may be tolerated. Examples of such antigens include Her2/neu and the B-cell antigen CD20. Humanized monoclonal antibodies directed to Her2/neu (Herceptin®/trastuzumab) are currently in use for the treatment of metastatic breast cancer. Ross and Fletcher (1998) Stem Cells 16:413-428. Similarly, anti-CD20 monoclonal antibodies (Rituxin®/rituximab) are used to effectively treat non-Hodgkin's lymphoma. Maloney, et al. (1997) Blood 90:2188-2195; Leget and Czuczman (1998) Curr. Opin. Oncol. 10:548-551. Potential immunotherapeutic targets have been identified for ovarian cancer. One such target is polymorphic epithelial mucin (MUCl). MUCl is a transmembrane protein, present at the apical surface of glandular epithelial cells. It is often overexpressed in ovarian cancer, and typically exhibits an altered glycosylation pattern, resulting in an antigenically distinct molecule, and is in early clinical trials as a vaccine target. Gilewski, et al. (2000) Clin. Cancer Res. 6:1693-1701; Scholl, et al. (2000) J. Immuno her. 23:570-580. The tumor- expressed protein is often cleaved into the circulation, where it is detectable as the tumor marker, CA 15-3. See, e.g., Bon, et al. (1997) Clin. Chem. 43:585-593. However, many patients have tumors that express neither HER2 nor MUC-1; therefore, it is clear that other targets need to be identified to manage localized and metastatic disease.

Mutations in both BRCA1 and BRCA2 are associated with increased susceptibility to ovarian cancer. Mutations in BRCA1 occur in approximately 5 percent (95 percent confidence interval, 3 to 8 percent) of women in whom ovarian cancer is diagnosed before the age of 70 years. See Stratton. et al. (1997) N.E.J. Med. 336:1125-1130. And, in BRCAl gene carriers, the risk for developing ovarian cancer is .63. See Easton (1995) Am. J. Hum- Genet. 56:267-xxx; and Elit (2001) Can. Fam. Physician 47:778-84.

Other biochemical markers such as CA125 have been reported to be associated with ovarian cancer, but they are not absolute indicators of disease. Although roughly 85% of Women with clinically apparent ovarian cancer have increased levels of CA125, CA125 is also increased during the first trimester of pregnancy, during menstruation, in the presence of non-cancerous illnesses, and in cancers of other sites.

While industry and academia have identified novel gene sequences, there has not been an equal effort exerted to identify the function of these novel sequences. The elucidation of a role for novel proteins and compounds in disease states for identification of therapeutic targets and diagnostic markers is essential for improving the current treatment of ovarian cancer patients. Accordingly, provided herein are molecular targets for therapeutic intervention in ovarian and other cancers. Additionally, provided herein are methods that can be used in diagnosis and prognosis of ovarian cancer. Further provided are methods that can be used to screen candidate bioactive agents for the ability to modulate ovarian cancer.

SUMMARY OF THE INVENTION The present invention therefore provides nucleotide sequences of genes that are up- and down-regulated in ovarian cancer cells. Such genes are useful for diagnostic purposes, and also as targets for screening for therapeutic compounds that modulate ovarian cancer, such as hormones or antibodies. The methods of detecting nucleic acids ofthe invention or their encoded proteins can be used for many purposes, e.g., early detection of ovarian cancers, monitoring and early detection of relapse following treatment, monitoring response to therapy, selecting patients for postoperative chemotherapy or radiation therapy, selecting therapy, determining tumor prognosis, treatment, or response to treatment (of primary or metastatic tumors), and early detection of pre-cancerous lesions. Other aspects ofthe invention will become apparent to the skilled artisan by the following description ofthe invention.

In one aspect, the present invention provides a method of detecting an ovarian cancer- associated transcript in a cell from a patient, the method comprising contacting a biological sample from the patient with a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1-26.

In one embodiment, the present invention provides a method of determining the level of an ovarian cancer associated transcript in a cell from a patient.

In one embodiment, the present invention provides a method of detecting an ovarian cancer-associated transcript in a cell from a patient, the method comprising contacting a biological sample from the patient with a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1-26.

In one embodiment, the polynucleotide selectively hybridizes to a sequence at least 95% identical to a sequence as shown in Tables 1-26. In one embodiment, the biological sample is a tissue sample. In another embodiment, the biological sample comprises isolated nucleic acids, e.g., mRNA.

In one embodiment, the polynucleotide is labeled, e.g., with a fluorescent label. In one embodiment, the polynucleotide is immobilized on a solid surface. In one embodiment, the patient is undergoing a therapeutic regimen to treat ovarian cancer. In another embodiment, the patient is suspected of having metastatic ovarian cancer. In one embodiment, the patient is a human. In one embodiment, the ovarian cancer associated transcript is mRNA.

In one embodiment, the method further comprises the step of amplifying nucleic acids before the step of contacting the biological sample with the polynucleotide.

In another aspect, the present invention provides a method of monitoring the efficacy of a therapeutic treatment of ovarian cancer, the method comprising the steps of: (i) providing a biological sample from a patient undergoing the therapeutic treatment; and (ii) determining the level of an ovarian cancer-associated transcript in the biological sample by contacting the biological sample with a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1-26, thereby monitoring the efficacy ofthe therapy. In a further embodiment, the patient has metastatic ovarian cancer. In a further embodiment, the patient has a drug resistant form of ovarian cancer. In one embodiment, the method further comprises the step of: (iii) comparing the level ofthe ovarian cancer-associated transcript to a level ofthe ovarian cancer-associated transcript in a biological sample from the patient prior to, or earlier in, the therapeutic treatment.

Additionally, provided herein is a method of evaluating the effect of a candidate ovarian cancer drug comprising administering the drug to a patient and removing a cell sample from the patient. The expression profile ofthe cell is then determined. This method may further comprise comparing the expression profile to an expression profile of a healthy individual. In a prefened embodiment, said expression profile includes a gene of Tables 1- 26. In one aspect, the present invention provides an isolated nucleic acid molecule consisting of a polynucleotide sequence as shown in Tables 1-26.

In one embodiment, an expression vector or cell comprises the isolated nucleic acid. In one aspect, the present invention provides an isolated polypeptide which is encoded by a nucleic acid molecule having polynucleotide sequence as shown in Tables 1-26. In another aspect, the present invention provides an antibody that specifically binds to an isolated polypeptide which is encoded by a nucleic acid molecule having polynucleotide sequence as shown in Tables 1-26.

In one embodiment, the antibody is conjugated to an effector component, e.g., a fluorescent label, a radioisotope or a cytotoxic chemical. In one embodiment, the antibody is an antibody fragment. In another embodiment, the antibody is humanized.

In one aspect, the present invention provides a method of detecting an ovarian cancer cell in a biological sample from a patient, the method comprising contacting the biological sample with an antibody as described herein.

In another aspect, the present invention provides a method of detecting antibodies specific to ovarian cancer in a patient, the method comprising contacting a biological sample from the patient with a polypeptide encoded by a nucleic acid comprising a sequence from Tables 1-26.

In another aspect, the present invention provides a method for identifying a compound that modulates an ovarian cancer-associated polypeptide, the method comprising the steps of: (i) contacting the compound with an ovarian cancer-associated polypeptide, the polypeptide encoded by a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1-26; and (ii) determining the functional effect ofthe compound upon the polypeptide.

In one embodiment, the functional effect is a physical effect, an enzymatic effect, or a chemical effect.

In one embodiment, the polypeptide is expressed in a eukaryotic host cell or cell membrane. In another embodiment, the polypeptide is recombinant.

In one embodiment, the functional effect is determined by measuring ligand binding to the polypeptide.

In another aspect, the present invention provides a method of inhibiting proliferation of an ovarian cancer-associated cell to treat ovarian cancer in a patient, the method comprising the step of administering to the subject a therapeutically effective amount of a compound identified as described herein.

In one embodiment, the compound is an antibody.

In another aspect, the present invention provides a drug screening assay comprising the steps of: (i) administering a test compound to a mammal having ovarian cancer or to a cell sample isolated from; (ii) comparing the level of gene expression of a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1-26 in a treated cell or mammal with the level of gene expression ofthe polynucleotide in a control cell sample or mammal, wherein a test compound that modulates the level of expression of the polynucleotide is a candidate for the treatment of ovarian cancer. In one embodiment, the control is a mammal with ovarian cancer or a cell sample that has not been treated with the test compound. In another embodiment, the control is a normal cell or mammal, or is non-malignant tissue.

In one embodiment, the test compound is administered in varying amounts or concentrations. In another embodiment, the test compound is administered for varying time periods. In another embodiment, the comparison can occur after addition or removal ofthe drug candidate.

In one embodiment, the levels of a plurality of polynucleotides that selectively hybridize to a sequence at least 80% identical to a sequence as shown in Tables 1-26 are individually compared to their respective levels in a control cell sample or mammal. In a preferced embodiment the plurality of polynucleotides is from three to ten.

In another aspect, the present invention provides a method for treating a mammal having ovarian cancer comprising administering a compound identified by the assay described herein.

In another aspect, the present invention provides a pharmaceutical composition for treating a mammal having ovarian cancer, the composition comprising a compound identified by the assay described herein and a physiologically acceptable excipient.

In one aspect, the present invention provides a method of screening drug candidates by providing a cell expressing a gene that is up- and down-regulated as in an ovarian cancer. In one embodiment, a gene is selected from Tables 1-26. The method further includes adding a drug candidate to the cell and determining the effect ofthe drug candidate on the expression ofthe expression profile gene.

In one embodiment, the method of screening drug candidates includes comparing the level of expression in the absence ofthe drug candidate to the level of expression in the presence ofthe drug candidate, wherein the concentration ofthe drug candidate can vary when present, and wherein the comparison can occur after addition or removal ofthe drug candidate. In a preferred embodiment, the cell expresses at least two expression profile genes. The profile genes may show an increase or decrease. Also provided is a method of evaluating the effect of a candidate ovarian cancer drug comprising administering the drug to a transgenic animal expressing or over-expressing the ovarian cancer modulatory protein, or an animal lacking the ovarian cancer modulatory protein, for example as a result of a gene knockout.

Moreover, provided herein is a biochip comprising one or more nucleic acid segments of Tables 1-26, wherein the biochip comprises fewer than 1000 nucleic acid probes.

Preferably, at least two nucleic acid segments are included. More preferably, at least three nucleic acid segments are included.

Furthermore, a method of diagnosing a disorder associated with ovarian cancer is provided. The method comprises determining the expression of a gene of Tables 1-26 in a first tissue type of a first individual, and comparing the distribution to the expression ofthe gene from a second normal tissue type from the first individual or a second unaffected individual. A difference in the expression indicates that the first individual has a disorder associated with ovarian cancer.

In a further embodiment, the biochip also includes a polynucleotide sequence of a gene that is not up- and down-regulated in ovarian cancer.

In one embodiment a method for screening for a bioactive agent capable of interfering with the binding of an ovarian cancer modulating protein (ovarian cancer modulatory protein) or a fragment thereof and an antibody which binds to said ovarian cancer modulatory protein or fragment thereof. In a prefened embodiment, the method comprises combining an ovarian cancer modulatory protein or fragment thereof, a candidate bioactive agent and an antibody which binds to said ovarian cancer modulatory protein or fragment thereof. The method further includes determining the binding of said ovarian cancer modulatory protein or fragment thereof and said antibody. Wherein there is a change in binding, an agent is identified as an interfering agent. The interfering agent can be an agonist or an antagonist. Preferably, the agent inhibits ovarian cancer.

Also provided herein are methods of eliciting an immune response in an individual. In one embodiment a method provided herein comprises administering to an individual a composition comprising an ovarian cancer modulating protein, or a fragment thereof. In another embodiment, the protein is encoded by a nucleic acid selected from those of Tables 1-26.

Further provided herein are compositions capable of eliciting an immune response in an individual, hi one embodiment, a composition provided herein comprises an ovarian cancer modulating protein, preferably encoded by a nucleic acid of Table 1 -26 or a fragment thereof, and a pharmaceutically acceptable carrier. In another embodiment, said composition comprises a nucleic acid comprising a sequence encoding an ovarian cancer modulating protein, preferably selected from the nucleic acids of Tables 1-26, and a pharmaceutically acceptable carrier. Also provided are methods of neutralizing the effect of an ovarian cancer protein, or a fragment thereof, comprising contacting an agent specific for said protein with said protein in an amount sufficient to effect neutralization. In another embodiment, the protein is encoded by a nucleic acid selected from those of Tables 1-26. In another aspect ofthe invention, a method of treating an individual for ovarian cancer is provided. In one embodiment, the method comprises administering to said individual an inhibitor of an ovarian cancer modulating protein. In another embodiment, the method comprises administering to a patient having ovarian cancer an antibody to an ovarian cancer modulating protein conjugated to a therapeutic moiety. Such a therapeutic moiety can be a cytotoxic agent or a radioisotope.

DETAILED DESCRIPTION OF THE INVENTION In accordance with the objects outlined above, the present invention provides novel methods for diagnosis and prognosis evaluation for ovarian cancer (OC), including metastatic ovarian cancer, as well as methods for screening for compositions which modulate ovarian cancer. Also provided are methods for treating ovarian cancer and related conditions, e.g., ovarian carcinoma (e.g., epithelial (including malignant serous tumors, malignant mucinous tumors, and malignant endometrioid tumors), germ cell (including teratomas, choriocarcinomas, polyembryomas, embryonal carcinoma, endodermal sinus tumor, dysgerminoma, and gonadoblastoma), and stromal carcinomas (e.g., granulosal stromal cell tumors)), fallopian tube carcinoma, and peritoneal carcinoma.

Tables 1-26 provide unigene cluster identification numbers for the nucleotide sequence of genes that exhibit increased or decreased expression in ovarian cancer samples. Tables 1-26 also provide an exemplar accession number that provides a nucleotide sequence that is part ofthe unigene cluster.

Definitions

The term "ovarian cancer protein" or "ovarian cancer polynucleotide" or "ovarian cancer-associated transcript" refers to nucleic acid and polypeptide polymorphic variants, alleles, mutants, and interspecies homologues that: (1) have a nucleotide sequence that has greater than about 60% nucleotide sequence identity, 65%, 70%, 75%, 80%, 85%, 90%, preferably 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% or greater nucleotide sequence identity, preferably over a region of over a region of at least about 25, 50, 100, 200, 500, 1000, or more nucleotides, to a nucleotide sequence of or associated with a gene of Tables 1-26; (2) bind to antibodies, e.g., polyclonal antibodies, raised against an immunogen comprising an amino acid sequence encoded by a nucleotide sequence of or associated with a gene of Tables 1-26, and conservatively modified variants thereof; (3) specifically hybridize under stringent hybridization conditions to a nucleic acid sequence, or the complement thereof of Tables 1-26 and conservatively modified variants thereof; or (4) have an amino acid sequence that has greater than about 60% amino acid sequence identity, 65%, 70%, 75%, 80%, 85%, 90%, preferably 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% or greater amino sequence identity, preferably over a region of over a region of at least about 25, 50,

100, 200, 500, 1000, or more amino acid, to an amino acid sequence encoded by a nucleotide sequence of or associated with a gene of Tables 1-26. A polynucleotide or polypeptide sequence is typically from a mammal including, but not limited to, primate, e.g., human; rodent, e.g., rat, mouse, hamster; cow, pig, horse, sheep, or other mammal. An "ovarian cancer polypeptide" and an "ovarian cancer polynucleotide," include both naturally occmring or recombinant forms. A "full length" ovarian cancer protein or nucleic acid refers to an ovarian cancer polypeptide or polynucleotide sequence, or a variant thereof, that contains all ofthe elements normally contained in one or more naturally occurring, wild type ovarian cancer polynucleotide or polypeptide sequences. The "full length" may be prior to, or after, various stages of post-translation processing or splicing, including alternative splicing. "Biological sample" as used herein is a sample of biological tissue or fluid that contains nucleic acids or polypeptides, e.g., of an ovarian cancer protein, polynucleotide or transcript. Such samples include, but are not limited to, tissue isolated from primates, e.g., humans, or rodents, e.g., mice, and rats. Biological samples may also include sections of tissues such as biopsy and autopsy samples, frozen sections taken for histo logic purposes, blood, plasma, serum, sputum, stool, tears, mucus, hair, skin, etc. Biological samples also include explants and primary and/or transformed cell cultures derived from patient tissues. A biological sample is typically obtained from a eukaryotic organism, most preferably a mammal such as a primate e.g., chimpanzee or human; cow; dog; cat; a rodent, e.g., guinea pig, rat, mouse; rabbit; or a bird; reptile; or fish. Livestock and domestic animals are of particular interest.

"Providing a biological sample" means to obtain a biological sample for use in methods described in this invention. Most often, this will be done by removing a sample of cells from an animal, but can also be accomplished by using previously isolated cells (e.g., isolated by another person, at another time, and/or for another purpose), or by performing the methods ofthe invention in vivo. Archival tissues, having treatment or outcome history, will be particularly useful.

The terms "identical" or percent "identity," in the context of two or more nucleic acids or polypeptide sequences, refer to two or more sequences or subsequences that are the same or have a specified percentage of amino acid residues or nucleotides that are the same (e.g., about 60% identity, preferably 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%,

95%, 96%, 97%, 98%, 99%, or higher identity over a specified region, when compared and aligned for maximum conespondence over a comparison window or designated region) as measured using a BLAST or BLAST 2.0 sequence comparison algorithms with default parameters described below, or by manual alignment and visual inspection (see, e.g., NCBI web site http://www.ncbi.nlm.nih.gov/BLAST/ or the like). Such sequences are then said to be "substantially identical." This definition also refers to, or may be applied to, the compliment of a test sequence. The definition also includes sequences that have deletions and/or additions, as well as those that have substitutions, as well as naturally occurring, e.g., polymorphic or allelic variants, and man-made variants. As described below, the prefereed algorithms can account for gaps and the like. Preferably, identity exists over a region that is at least about 25 amino acids or nucleotides in length, or more preferably over a region that is 50-100 amino acids or nucleotides in length. For sequence comparison, typically one sequence acts as a reference sequence, to which test sequences are compared. When using a sequence comparison algorithm, test and reference sequences are entered into a computer, subsequence coordinates are designated, if necessary, and sequence algorithm program parameters are designated. Preferably, default program parameters can be used, or alternative parameters can be designated. The sequence comparison algorithm then calculates the percent sequence identities for the test sequences relative to the reference sequence, based on the program parameters.

A "comparison window", as used herein, includes reference to a segment of one ofthe number of contiguous positions selected from the group consisting typically of from 20 to 600, usually about 50 to about 200, more usually about 100 to about 150 in which a sequence may be compared to a reference sequence ofthe same number of contiguous positions after the two sequences are optimally aligned. Methods of alignment of sequences for comparison are well-known in the art. Optimal alignment of sequences for comparison can be conducted, e.g., by the local homology algorithm of Smith and Waterman (1981) Adv. Appl. Math. 2:482-489, by the homology alignment algorithm of Needleman and Wunsch (1970) J. Mol. Biol. 48:443-453, by the search for similarity method of Pearson and Lipman (1988) Proc. NatT. Acad. Sci. USA 85:2444-2448, by computerized implementations of these algorithms (GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Genetics Computer Group, 575 Science Dr., Madison, Wl), or by manual alignment and visual inspection (see, e.g., Ausubel, et al. (eds. 1995 and supplements) Cunent Protocols in Molecular Biology Lippincott.

Prefened examples of algorithms that are suitable for determining percent sequence identity and sequence similarity include the BLAST and BLAST 2.0 algorithms, which are described in Altschul, et al. (1977) Nuc. Acids Res. 25:3389-3402 and Altschul, et al. (1990) J. Mol. Biol. 215:403-410. BLAST and BLAST 2.0 are used, with the parameters described herein, to determine percent sequence identity for the nucleic acids and proteins ofthe invention. Software for performing BLAST analyses is publicly available through the National Center for Biotechnology Information (http://www.ncbi.nlm.nih.gov/). This algorithm involves first identifying high scoring sequence pairs (HSPs) by identifying short words of length W in the query sequence, which either match or satisfy some positive- valued threshold score T when aligned with a word ofthe same length in a database sequence. T is refened to as the neighborhood word score threshold (Altschul, et al., supra). These initial neighborhood word hits act as seeds for initiating searches to find longer HSPs containing them. The word hits are extended in both directions along each sequence for as far as the cumulative alignment score can be increased. Cumulative scores are calculated using, e.g., for nucleotide sequences, the parameters M (reward score for a pair of matching residues; always > 0) and N (penalty score for mismatching residues; always < 0). For amino acid sequences, a scoring matrix is used to calculate the cumulative score. Extension ofthe word hits in each direction are halted when: the cumulative alignment score falls off by the quantity X from its maximum achieved value; the cumulative score goes to zero or below, due to the accumulation of one or more negative-scoring residue alignments; or the end of either sequence is reached. The BLAST algorithm parameters W, T, and X determine the sensitivity and speed ofthe alignment. The BLASTN program (for nucleotide sequences) uses as defaults a wordlength (W) of 11, an expectation (E) of 10, M=5, N=-4 and a comparison of both strands. For amino acid sequences, the BLASTP program uses as defaults a word length of 3, and expectation (E) of 10, and the BLOSUM62 scoring matrix (see Henikoff and Henikoff (1989) Proc. Nat'l Acad. Sci. USA 89:10915-919) alignments (B) of 50, expectation (E) of 10, M=5, N=-4, and a comparison of both strands. The BLAST algorithm also performs a statistical analysis ofthe similarity between two sequences (see, e.g., Karlin and Altschul (1993) Proc. NatT Acad. Sci. USA 90:5873- 5887). One measure of similarity provided by the BLAST algorithm is the smallest sum probability (P(N)), which provides an indication ofthe probability by which a match between two nucleotide or amino acid sequences would occur by chance. For example, a nucleic acid is considered similar to a reference sequence if the smallest sum probability in a comparison ofthe test nucleic acid to the reference nucleic acid is less than about 0.2, more preferably less than about 0.01, and most preferably less than about 0.001. Log values may be large negative numbers, e.g., 5, 10, 20, 30, 40, 40, 70, 90, 110, 150, 170, etc. An indication that two nucleic acid sequences or polypeptides are substantially identical is that the polypeptide encoded by the first nucleic acid is immunologically cross reactive with the antibodies raised against the polypeptide encoded by the second nucleic acid, as described below. Thus, a polypeptide is typically substantially identical to a second polypeptide, e.g., where the two peptides differ only by conservative substitutions. Another indication that two nucleic acid sequences are substantially identical is that the two molecules or their complements hybridize to each other under stringent conditions, as described below. Yet another indication that two nucleic acid sequences are substantially identical is that the same primers can be used to amplify the sequences. A "host cell" is a naturally occuning cell or a transformed cell that contains an expression vector and supports the replication or expression ofthe expression vector. Host cells may be cultured cells, explants, cells in vivo, and the like. Host cells may be prokaryotic cells such as E. coli, or eukaryotic cells such as yeast, insect, amphibian, or mammalian cells, such as CHO, HeLa, and the like (see, e.g., the American Type Culture Collection catalog or web site, www.atcc.org).

The terms "isolated," "purified," or "biologically pure" refer to material that is substantially or essentially free from components that normally accompany it as found in its native state. Purity and homogeneity are typically determined using analytical chemistry techniques such as polyacrylamide gel electrophoresis or high performance liquid chromatography. A protein or nucleic acid that is the predominant species present in a preparation is substantially purified. In particular, an isolated nucleic acid is separated from some open reading frames that naturally flank the gene and encode proteins other than protein encoded by the gene. The term "purified" in some embodiments denotes that a nucleic acid or protein gives rise to essentially one band in an electrophoretic gel. Preferably, it means that the nucleic acid or protein is at least 85% pure, more preferably at least 95% pure, and most preferably at least 99% pure. "Purify" or "purification" in other embodiments means removing at least one contaminant from the composition to be purified. In this sense, purification does not require that the purified compound be homogenous, e.g., 100% pure. The terms "polypeptide," "peptide" and "protein" are used interchangeably herein to refer to a polymer of amino acid residues. The terms apply to amino acid polymers in which one or more amino acid residue is an artificial chemical mimetic of a conesponding naturally occurring amino acid, as well as to naturally occurring amino acid polymers, those containing modified residues, and non-naturally occurring amino acid polymers. The term "amino acid" refers to naturally occurring and synthetic amino acids, as well as amino acid analogs and amino acid mimetics that function similarly to the natu ally occurring amino acids. Naturally occurring amino acids are those encoded by the genetic code, as well as those amino acids that are later modified, e.g., hydroxyproline, γ- carboxyglutamate, and O-phosphoserine. Amino acid analogs refers to compounds that have the same basic chemical structure as a naturally occuning amino acid, e.g., an α carbon that is bound to a hydrogen, a carboxyl group, an amino group, and an R group, e.g., homoserine, norleucine, methionine sulfoxide, methionine methyl sulfonium. Such analogs may have modified R groups (e.g., norleucine) or modified peptide backbones, but retain the same basic chemical structure as a naturally occurring amino acid. Amino acid mimetics refers to chemical compounds that have a structure that is different from the general chemical structure of an amino acid, but that functions similarly to a naturally occuning amino acid. Amino acids may be refened to herein by either their commonly known three letter symbols or by the one-letter symbols recommended by the IUPAC-IUB Biochemical Nomenclature Commission. Nucleotides, likewise, may be refened to by their commonly ' accepted single-letter codes.

"Conservatively modified variants" applies to both amino acid and nucleic acid sequences. With respect to particular nucleic acid sequences, conservatively modified variants refers to those nucleic acids which encode identical or essentially identical amino acid sequences, or where the nucleic acid does not encode an amino acid sequence, to essentially identical or associated, e.g., naturally contiguous, sequences. Because ofthe degeneracy ofthe genetic code, a large number of functionally identical nucleic acids encode most proteins. For instance, the codons GCA, GCC, GCG, and GCU all encode the amino acid alanine. Thus, at every position where an alanine is specified by a codon, the codon can be altered to another ofthe conesponding codons described without altering the encoded polypeptide. Such nucleic acid variations are "silent variations," which are one species of conservatively modified variations. Every nucleic acid sequence herein which encodes a polypeptide also describes silent variations ofthe nucleic acid. In certain contexts each codon in a nucleic acid (except AUG, which is ordinarily the only codon for methionine, and TGG, which is ordinarily the only codon for tryptophan) can be modified to yield a functionally identical molecule. Accordingly, a silent variation of a nucleic acid which encodes a polypeptide is implicit in a described sequence with respect to the expression product, but not necessarily with respect to actual probe sequences. As to amino acid sequences, one of skill will recognize that individual substitutions, deletions, or additions to a nucleic acid, peptide, polypeptide, or protein sequence which alters, adds, or deletes a single amino acid or a small percentage of amino acids in the encoded sequence is a "conservatively modified variant" where the alteration results in the substitution of an amino acid with a chemically similar amino acid. Conservative substitution tables providing functionally similar amino acids are well known in the art. Such conservatively modified variants are in addition to and do not exclude polymorphic variants, interspecies homologs, and alleles ofthe invention. Typically conservative substitutions for one another: 1) Alanine (A), Glycine (G); 2) Aspartic acid (D), Glutamic acid (E); 3) Asparagine (N), Glutamine ( ); 4) Argimne (R), Lysine (K); 5) Isoleucine (I), Leucine (L), Methionine (M), Valine (V); 6) Phenylalanine (F), Tyrosine (Y), Tryptophan (W); 7) Serine (S), Threonine (T); and 8) Cysteine (C), Methionine (M) (see, e.g., Creighton (1984) Proteins Freeman).

Macromolecular structures such as polypeptide structures can be described in terms of various levels of organization. For a general discussion of this organization, see, e.g.,

Alberts, et al. (2001) Molecular Biology ofthe Cell (4th ed.) Garland Pub.; and Cantor and Schimmel (1980) Biophysical Chemistry Part I: The Conformation of Biological Macromolecules Freeman. "Primary structure" refers to the amino acid sequence of a particular peptide. "Secondary structure" refers to locally ordered, three dimensional structures within a polypeptide. These structures are commonly known as domains.

Domains are portions of a polypeptide that often form a compact unit ofthe polypeptide and are typically 25 to approximately 500 amino acids long. Typical domains are made up of sections of lesser organization such as stretches of β-sheet and α-helices. "Tertiary structure" refers to the complete three dimensional structure of a polypeptide monomer. "Quaternary structure" refers to the three dimensional structure formed, usually by the non-covalent association of independent tertiary units. Anisotropic terms are also known as energy terms. "Nucleic acid" or "oligonucleotide" or "polynucleotide" or grammatical equivalents used herein means at least two nucleotides covalently linked together. Oligonucleotides are typically from about 5, 6, 7, 8, 9, 10, 12, 15, 25, 30, 40, 50, or more nucleotides in length, up to about 100 nucleotides in length. Nucleic acids and polynucleotides are a polymers of any length, including longer lengths, e.g., 200, 300, 500, 1000, 2000, 3000, 5000, 7000, 10,000, etc. A nucleic acid ofthe present invention will generally contain phosphodiester bonds, although in some cases, nucleic acid analogs are included that may have at least one different linkage, e.g., phosphoramidate, phosphorofhioate, phosphorodithioate, or O- methylphosphoroamidite linkages (see Eckstein (1992) Oligonucleotides and Analogues: A Practical Approach Oxford University Press); and peptide nucleic acid backbones and linkages. Other analog nucleic acids include those with positive backbones; non-ionic backbones, and non-ribose backbones, including those described in U.S. Patent Nos. 5,235,033 and 5,034,506, and Chapters 6 and 7 of Sanghvi and Cook (eds. 1994) Carbohydrate Modifications in Antisense Research ASC Symposium Series 580. Nucleic acids containing one or more carbocyclic sugars are also included within one definition of nucleic acids. Modifications ofthe ribose-phosphate backbone may be done for a variety of reasons, e.g., to increase the stability and half-life of such molecules in physiological environments or as probes on a biochip. Mixtures of naturally occurring nucleic acids and analogs can be made; alternatively, mixtures of different nucleic acid analogs, and mixtures of naturally occurring nucleic acids and analogs may be made. A variety of references disclose such nucleic acid analogs, including, e.g., phosphoramidate (Beaucage, et al. (1993) Tetrahedron 49:1925-1963 and references therein; Letsinger (1970) J. Org. Chem. 35:3800-3803; Sprinzl, et al. (1977) Eur. J. Biochem. 81:579- 589; Letsinger, et al. (1986) Nucl. Acids Res. 14:3487-499; Sawai, et al. (1984) Chem. Lett. 805, Letsinger, et al. (1988) J. Am. Chem. Soc. 110:4470-4471; and Pauwels, et al. (1986), Chemica Scripta 26:141-149), phosphorothioate (Mag, et al. (1991) Nucl. Acids Res.

19:1437-441; and U.S. Patent No. 5,644,048), phosphorodithioate (Brill, et al. (1989) J. Am. Chem. Soc. 111:2321-2322), O-methylphophoroamidite linkages (see Eckstein (1992) Oligonucleotides and Analogues: A Practical Approach Oxford Univ. Press), and peptide nucleic acid backbones and linkages (see Egholm (1992) J. Am. Chem. Soc. 114:1895-897; Meier, et al. (1992) Angew. Chem. Int. Ed. Engl. 31:1008-1010: Nielsen (1993) Nature. 365:566-568; Carlsson, et al. (1996) Nature 380:207, each of which is incorporated by reference). Other analog nucleic acids include those with positive backbones (Denpcy, et al. (1995) Proc. Nat'l Acad. Sci. USA 92:6097-101; non-ionic backbones (U.S. Patent Nos. 5,386,023, 5,637,684, 5,602,240, 5,216,141 and 4,469,863; Kiedrowshi, et al. (1991) Angew. Chem. Intl. Ed. English 30:423-426; Letsinger, et al. (1988) J. Am. Chem. Soc. 110:4470-

4471; Jung, et al. (1994) Nucleoside and Nucleotide 13:1597; Chapters 2 and 3, in Sanghvi and Cook (eds. 1994) Carbohydrate Modifications in Antisense Research ASC Symposium

Series 580; Mesmaeker, et al. (1994) Bioorganic and Medicinal Chem. Lett. 4:395-398; Jeffs, et al. (1994) J. Biomolecular NMR 34:17-xx; Horn, et al. (1996) Tetrahedron Lett. 37:743- xxx) and non-ribose backbones, including those described in U.S. Patent Nos. 5,235,033 and 5,034,506, and Chapters 6 and 7, in Sanghvi and Cook (eds. 1994) Carbohydrate Modifications in Antisense Research ASC Symposium Series 580. Nucleic acids containing one or more carbocyclic sugars are also included within one definition of nucleic acids (see Jenkins, et al. (1995) Chem. Soc. Rev, pp 169-176). Several nucleic acid analogs are described in Rawls (p. 35 June 2, 1997) C&E News. Each of these references is hereby expressly incorporated by reference.

Particularly prefened are peptide nucleic acids (PNA) which includes peptide nucleic acid analogs. These backbones are substantially non-ionic under neutral conditions, in contrast to the highly charged phosphodiester backbone of naturally occurring nucleic acids. This results in two advantages. First, the PNA backbone exhibits improved hybridization kinetics. PNAs have larger changes in the melting temperature (T_m) for mismatched versus perfectly matched base pairs. DNA and RNA typically exhibit a 2-4° C drop in T_m for an internal mismatch. With the non-ionic PNA backbone, the drop is closer to 7-9° C. Similarly, due to their non-ionic nature, hybridization ofthe bases attached to these backbones is relatively insensitive to salt concentration. In addition, PNAs are not degraded by cellular enzymes, and thus can be more stable.

The nucleic acids may be single stranded or double stranded, as specified, or contain portions of both double stranded or single stranded sequence. As will be appreciated by those in the art, the depiction of a single strand also defines the sequence ofthe complementary strand; thus the sequences described herein also provide the complement ofthe sequence. The nucleic acid may be DNA, both genomic and cDNA, RNA, or a hybrid, where the nucleic acid may contain combinations of deoxyribo- and ribo-nucleotides, and combinations of bases, including uracil, adenine, thymine, cytosine, guanine, inosine, xanthine hypoxanthine, isocytosine, isoguanine, etc. "Transcript" typically refers to a naturally occurring RNA, e.g., a pre-mRNA, hnRNA, or mRNA. As used herein, the term "nucleoside" includes nucleotides and nucleoside and nucleotide analogs, and modified nucleosides such as amino modified nucleosides. In addition, "nucleoside" includes non- naturally occurring analog structures. Thus, e.g., the individual units of a peptide nucleic acid, each containing a base, are refened to herein as a nucleoside.

A "label" or a "detectable moiety" is a composition detectable by spectroscopic, photochemical, biochemical, immunochemical, chemical, or other physical means. For example, useful labels include 32p₃ fluorescent dyes, electron-dense reagents, enzymes (e.g., as commonly used in an ELISA), biotin, digoxigenin, or haptens and proteins or other entities which can be made detectable, e.g., by incorporating a radiolabel into the peptide or used to detect antibodies specifically reactive with the peptide. The labels may be incorporated into the ovarian cancer nucleic acids, proteins and antibodies at any position. Any method known in the art for conjugating the antibody to the label may be employed, including those methods described by Hunter, et al. (1962) Nature 144:945-xxx; David, et al. (1974) Biochemistry 13:1014-1021; Pain, et al. (1981) J. Immunol. Meth. 40:219-230; and Nygren (1982) Histochem. and Cvtochem. 30:407-412.

An "effector" or "effector moiety" or "effector component" is a molecule that is bound (or linked, or conjugated), either covalently, through a linker or a chemical bond, or non-covalently, through ionic, van der Waals, electrostatic, or hydrogen bonds, to an antibody. The "effector" can be a variety of molecules including, e.g., detection moieties including radioactive compounds, fluorescent compounds, an enzyme or substrate, tags such as epitope tags, a toxin; activatable moieties, a chemotherapeutic agent; a lipase; an antibiotic; or a radioisotope emitting "hard" e.g., beta radiation.

A "labeled nucleic acid probe or oligonucleotide" is one that is bound, either covalently, through a linker or a chemical bond, or non-covalently, through ionic, van der Waals, electrostatic, or hydrogen bonds to a label such that the presence ofthe probe may be detected by detecting the presence ofthe label bound to the probe. Alternatively, method using high affinity interactions may achieve the same results where one of a pair of binding partners binds to the other, e.g., biotin, streptavidin.

As used herein a "nucleic acid probe or oligonucleotide" is a nucleic acid capable of binding to a target nucleic acid of complementary sequence through one or more types of chemical bonds, usually through complementary base pairing, usually through hydrogen bond formation. As used herein, a probe may include natural (e.g., A, G, C, or T) or modified bases (7-deazaguanosine, inosine, etc.). In addition, the bases in a probe may be joined by a linkage other than a phosphodiester bond, so long as it does not functionally interfere with hybridization. Thus, e.g., probes may be peptide nucleic acids in which the constituent bases are joined by peptide bonds rather than phosphodiester linkages. Probes may bind target sequences lacking complete complementarity with the probe sequence depending upon the stringency ofthe hybridization conditions. The probes are preferably directly labeled, e.g., with isotopes, chromophores, lumiphores, chromogens, or indirectly labeled such as with biotin to which a streptavidin complex may later bind. By assaying for the presence or absence ofthe probe, one can detect the presence or absence ofthe select sequence or subsequence. Diagnosis or prognosis may be based at the genomic level, or at the level of RNA or protein expression.

The term "recombinant" when used with reference, e.g., to a cell, or nucleic acid, protein, or vector, indicates that the cell, nucleic acid, protein or vector, has been modified by the introduction of a heterologous nucleic acid or protein or the alteration of a native nucleic acid or protein, or that the cell is derived from a cell so modified. Thus, e.g., recombinant cells express genes that are not found within the native (non-recombinant) form ofthe cell or express native genes that are otherwise abnormally expressed, under expressed or not expressed at all. By the term "recombinant nucleic acid" herein is meant nucleic acid, originally formed in vitro, in general, by the manipulation of nucleic acid, e.g., using polymerases and endonucleases, in a form not normally found in nature. In this manner, operably linkage of different sequences is achieved. Thus an isolated nucleic acid, in a linear form, or an expression vector formed in vitro by ligating DNA molecules that are not normally joined, are both considered recombinant for the purposes of this invention. It is understood that once a recombinant nucleic acid is made and reintroduced into a host cell or organism, it will replicate non-recombinantly, e.g., using the in vivo cellular machinery ofthe host cell rather than in vitro manipulations; however, such nucleic acids, once produced recombinantly, although subsequently replicated non-recombinantly, are still considered recombinant for the purposes ofthe invention. Similarly, a "rec.ombinant protein" is a protein made using recombinant techniques, e.g., through the expression of a recombinant nucleic acid as depicted above.

The term "heterologous" when used with reference to portions of a nucleic acid indicates that the nucleic acid comprises two or more subsequences that are not normally found in the same relationship to each other in nature. For instance, the nucleic acid is typically recombinantly produced, having two or more sequences, e.g., from unrelated genes arranged to make a new functional nucleic acid, e.g., a promoter from one source and a coding region from another source. Similarly, a heterologous protein will often refer to two or more subsequences that are not found in the same relationship to each other in nature (e.g., a fusion protein). A "promoter" is defined as an array of nucleic acid control sequences that direct transcription of a nucleic acid. As used herein, a promoter includes necessary nucleic acid sequences near the start site of transcription, such as, in the case of a polymerase II type promoter, a TATA element. A promoter also optionally includes distal enhancer or repressor elements, which can be located as much as several thousand base pairs from the start site of transcription. A "constitutive" promoter is a promoter that is active under most environmental and developmental conditions. An "inducible" promoter is a promoter that is active under environmental or developmental regulation. The term "operably linked" refers to a functional linkage between a nucleic acid expression control sequence (such as a promoter, or anay of transcription factor binding sites) and a second nucleic acid sequence, e.g., wherein the expression control sequence directs transcription ofthe nucleic acid conesponding to the second sequence.

An "expression vector" is a nucleic acid construct, generated recombinantly or synthetically, with a series of specified nucleic acid elements that permit transcription of a particular nucleic acid in a host cell. The expression vector can be part of a plasmid, virus, or nucleic acid fragment. Typically, the expression vector includes a nucleic acid to be transcribed operably linked to a promoter.

The phrase "selectively (or specifically) hybridizes to" refers to the binding, duplexing, of hybridizing of a molecule only to a particular nucleotide sequence under stringent hybridization conditions when that sequence is present in a complex mixture (e.g., total cellular or library DNA or RNA).

The phrase "stringent hybridization conditions" refers to conditions under which a probe will hybridize to its target subsequence, typically in a complex mixture of nucleic acids, but to no other sequences. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridize specifically at higher temperatures. An extensive guide to the hybridization of nucleic acids is found in "Overview of principles of hybridization and the strategy of nucleic acid assays" in Tijssen (1993) Hybridization with Nucleic Probes (Laboratory Techniques in Biochemistry and Molecular Biology) (vol. 24) Elsevier. Generally, stringent conditions are selected to be about 5-10° C lower than the thermal melting point (T_m) for the specific sequence at a defined ionic strength pH. The T_m is the temperature (under defined ionic strength, pH, and nucleic concentration) at which 50% ofthe probes complementary to the target hybridize to the target sequence at equilibrium (as the target sequences are present in excess, at T_m, 50% ofthe probes are occupied at equilibrium). Stringent conditions will be those in which the salt concentration is less than about 1.0 M sodium ion, typically about 0.01 to 1.0 M sodium ion concentration (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30° C for short probes (e.g., 10 to 50 nucleotides) and at least about 60° C for long probes (e.g., greater than 50 nucleotides). Stringent conditions may also be achieved with the addition of destabilizing agents such as formamide. For selective or specific hybridization, a positive signal is typically at least two times background, preferably 10 times background hybridization. Exemplary stringent hybridization conditions can be as following: 50%) formamide, 5x SSC, and 1% SDS, incubating at 42° C, or, 5x SSC, 1% SDS, incubating at 65° C, with wash in 0.2x SSC, and 0.1% SDS at 65° C. For PCR, a temperature of about 36° C is typical for low stringency amplification, although annealing temperatures may vary between about 32-48° C depending on primer length. For high stringency PCR amplification, a temperature of about 62° C is typical, although high stringency annealing temperatures can range from about 50° C to about 65° C, depending on the primer length and specificity. Typical cycle conditions for both high and low stringency amplifications include a denaturation phase of 90-95° C for 30-120 sec, an annealing phase lasting 30-120 sec, and an extension phase of about 72° C for 1-2 min. Protocols and guidelines for low and high stringency amplification reactions are available, e.g., in Innis, et al. (1990) PCR Protocols: A Guide to Methods and Applications Academic Press, N. Y.

Nucleic acids that do not hybridize to each other under stringent conditions are still substantially identical if the polypeptides which they encode are substantially identical. This occurs, e.g., when a copy of a nucleic acid is created using the maximum codon degeneracy permitted by the genetic code. In such cases, the nucleic acids typically hybridize under moderately stringent hybridization conditions. Exemplary "moderately stringent hybridization conditions" include a hybridization in a buffer of 40% formamide, 1 M NaCl, 1% SDS at 37° C, and a wash in IX SSC at 45° C. A positive hybridization is at least twice background. Alternative hybridization and wash conditions can be utilized to provide conditions of similar stringency. Additional guidelines for determining hybridization parameters are provided, e.g., Ausubel, et al. (ed. 1991 and supplements) Current Protocols in Molecular Biology Lippincott.

The phrase "functional effects" in the context of assays for testing compounds that modulate activity of an ovarian cancer protein includes the determination of a parameter that is indirectly or directly under the influence ofthe ovarian cancer protein or nucleic acid, e.g., a functional, physical, physiological, or chemical effect, such as the ability to decrease ovarian cancer. It includes ligand binding activity; cell growth on soft agar; anchorage dependence; contact inhibition and density limitation of growth; cellular proliferation; cellular transformation; growth factor or serum dependence; tumor specific marker levels; invasiveness into Matrigel; tumor growth and metastasis in vivo; mRNA and protein expression in cells undergoing metastasis, and other characteristics of ovarian cancer cells. "Functional effects" include in vitro, in vivo, and ex vivo activities. By "determining the functional effect" is meant assaying for a compound that increases or decreases a parameter that is indirectly or directly under the influence of an ovarian cancer protein sequence, e.g., functional, enzymatic, physical, physiological, and chemical effects. Such functional effects can be measured by any means known to those skilled in the art, e.g., changes in spectroscopic characteristics (e.g., fluorescence, absorbance, refractive index), hydrodynamic (e.g., shape), chromatographic, or solubility properties for the protein, measuring inducible markers or transcriptional activation ofthe ovarian cancer protein; measuring binding activity or binding assays, e.g., binding to antibodies or other ligands, and measuring cellular proliferation. Determination ofthe functional effect of a compound on ovarian cancer can also be performed using ovarian cancer assays known to those of skill in the art such as an in vitro assays, e.g., cell growth on soft agar; anchorage dependence; contact inhibition and density limitation of growth; cellular proliferation; cellular transformation; growth factor or serum dependence; tumor specific marker levels; invasiveness into Matrigel; tumor growth and metastasis in vivo; mRNA and protein expression in cells undergoing metastasis, and other characteristics of ovarian cancer cells. The functional effects can be evaluated by means known to those skilled in the art, e.g., microscopy for quantitative or qualitative measures of alterations in morphological features, measurement of changes in RNA or protein levels for ovarian cancer-associated sequences, measurement of RNA stability, or identification of downstream or reporter gene expression (CAT, luciferase, β-gal, GFP, and the like), e.g., via chemiluminescence, fluorescence, colorimetric reactions, antibody binding, inducible markers, and ligand binding assays.

"Inhibitors", "activators", and "modulators" of ovarian cancer polynucleotide and polypeptide sequences are used to refer to activating, inhibitory, or modulating molecules or compounds identified using in vitro and in vivo assays of ovarian cancer polynucleotide and polypeptide sequences. Inhibitors are compounds that, e.g., bind to, partially or totally block activity, decrease, prevent, delay activation, inactivate, desensitize, or down regulate the activity or expression of ovarian cancer proteins, e.g., antagonists. Antisense or inhibitory nucleic acids may inhibit expression and subsequent function ofthe protein. "Activators" are compounds that increase, open, activate, facilitate, enhance activation, sensitize, agonize, or up regulate ovarian cancer protein activity, inhibitors, activators, or modulators also include genetically modified versions of ovarian cancer proteins, e.g., versions with altered activity, as well as naturally occurring and synthetic ligands, antagonists, agonists, antibodies, small chemical molecules, and the like. Assays for inhibitors and activators include, e.g., expressing the ovarian cancer protein in vitro, in cells, or cell membranes, applying putative modulator compounds, and then determining the functional effects on activity, as described above. Activators and inhibitors of ovarian cancer can also be identified by incubating ovarian cancer cells with the test compound and determining increases or decreases in the expression of one or more ovarian cancer proteins, e.g., 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 40, 50, or more ovarian cancer proteins, such as ovarian cancer proteins encoded by the sequences set out in Tables 1-26.

Samples or assays comprising ovarian cancer proteins that are treated with a potential activator, inhibitor, or modulator are compared to control samples without the inhibitor, activator, or modulator to examine the extent of inhibition. Control samples (untreated with inhibitors) are assigned a relative protein activity value of 100%. Inhibition of a polypeptide is achieved when the activity value relative to the control is about 80%, preferably 50%, more preferably 25% or less. Activation of an ovarian cancer polypeptide is achieved when the activity value relative to the control (untreated with activators) is 110%, more preferably 1.50%, more preferably 200-500% (e.g., 2-5 fold higher relative to the control), more preferably 1000-3000% higher.

The phrase "changes in cell growth" refers to a change in cell growth and proliferation characteristics in vitro or in vivo, e.g., cell viability, formation of foci, anchorage independence, semi-solid or soft agar growth, change in contact inhibition or density limitation of growth, loss of growth factor or serum requirements, change in cell morphology, gain or loss of immortalization, gain or loss of tumor specific markers, ability to form or suppress tumors when injected into suitable animal hosts, and/or immortalization of the cell. See, e.g., pp. 231-241 in Freshney (1994) Culture of Animal Cells: A Manual of

Basic Technique (3d ed.) Wiley-Liss. "Tumor cell" refers to pre-cancerous, cancerous, and normal cells in a tumor. "Cancer cells," "transformed" cells or "transformation" in tissue culture, refers to spontaneous or induced phenotypic changes that do not necessarily involve the uptake of new genetic material. Although transformation can arise from infection with a transforming virus and incorporation of new genomic DNA, or uptake of exogenous DNA, it can also arise spontaneously or following exposure to a carcinogen, thereby mutating an endogenous gene. Transformation is typically associated with phenotypic changes, such as immortalization of cells, abenant growth control, non-morphological changes, and/or malignancy. See, - Freshney (1994) Culture of Animal Cells. "Antibody" refers to a polypeptide comprising a framework region from an immunoglobulin gene or fragments thereof that specifically binds and recognizes an antigen. The recognized immunoglobulin genes include the kappa, lambda, alpha, gamma, delta, epsilon, and mu constant region genes, as well as the myriad immunoglobulin variable region genes. Light chains are classified as either kappa or lambda. Heavy chains are classified as gamma, mu, alpha, delta, or epsilon, which in turn define the immunoglobulin classes, IgG, IgM, IgA, IgD, and IgE, respectively. Typically, the antigen-binding region of an antibody or its functional equivalent will be most critical in specificity and affinity of binding. See, e.g., Paul (ed. 1999) Fundamental Immunology (4th ed.) Raven.

An exemplary immunoglobulin (antibody) structural unit comprises a tetramer. Each tetramer is composed of two identical pairs of polypeptide chains, each pair having one "light" (about 25 kD) and one "heavy" chain (about 50-70 kD). The N-terminus of each chain defines a variable region of about 100 to 110 or more amino acids primarily responsible for antigen recognition. The terms variable light chain (VjJ and variable heavy chain (VJJ) refer to these light and heavy chains respectively. Antibodies exist, e.g., as intact immunoglobulins or as a number of well-characterized fragments produced by digestion with various peptidases. Thus, e.g., pepsin digests an antibody below the disulfide linkages in the hinge region to produce F(ab)'2, a dimer of Fab which itself is a light chain joined to Vjj-Cfjl by a disulfide bond. The F(ab)'2 may be reduced under mild conditions to break the disulfide linkage in the hinge region, thereby converting the F(ab)'2 dimer into an Fab' monomer. The Fab' monomer is essentially Fab with part ofthe hinge region. See Paul (ed. 1999) Fundamental Immunology (4th ed.) Raven. While various antibody fragments are defined in terms ofthe digestion of an intact antibody, one of skill will appreciate that such fragments may be synthesized de novo either chemically or by using recombinant DNA methodology. Thus, the term antibody, as used herein, also includes antibody fragments either produced by the modification of whole antibodies, or those synthesized de novo using recombinant DNA methodologies (e.g., single chain Fv) or those identified using phage display libraries. See, e.g., McCafferty, et al. (1990) Nature 348:552-554.

For preparation of antibodies, e.g., recombinant, monoclonal, or polyclonal antibodies, many techniques known in the art can be used (see, e.g., Kohler and Milstein (1975) Nature 256:495-497; Kozbor, et al. (1983) Immunology Today 4:72; Cole, et al., pp. 77-96 in Reisfeld and Sell (1985) Monoclonal Antibodies and Cancer Therapy Liss; Coligan (1991) Cunent Protocols in Immunology Lippincott; Harlow and Lane (1988) Antibodies: A Laboratory Manual CSH Press; and Goding (1986) Monoclonal Antibodies: Principles and Practice (2d ed.) Academic Press. Techniques for the production of single chain antibodies (U.S. Patent 4,946,778) can be adapted to produce antibodies to polypeptides of this invention. Transgenic mice, or other organisms, e.g., other mammals, may be used to express humanized antibodies. Alternatively, phage display technology can be used to identify antibodies and heteromeric Fab fragments that specifically bind to selected antigens. See, e.g., McCafferty, et al. (1990) Nature 348:552-554; and Marks, et al. (1992) Biotechnology 10:779-783. A "chimeric antibody" is an antibody molecule in which (a) the constant region, or a portion thereof, is altered, replaced or exchanged so that the antigen binding site (variable region) is linked to a constant region of a different or altered class, effector function and/or species, or an entirely different molecule which confers new properties to the chimeric antibody, e.g., an enzyme, toxin, hormone, growth factor, drug, etc.; or (b) the variable region, or a portion thereof, is altered, replaced or exchanged with a variable region having a different or altered antigen specificity.

Identification of ovarian cancer-associated sequences

In one aspect, the expression levels of genes are determined in different patient samples for which diagnosis information is desired, to provide expression profiles. An expression profile of a particular sample is essentially a "fingerprint" ofthe state ofthe sample; while two states may have any particular gene similarly expressed, the evaluation of a number of genes simultaneously allows the generation of a gene expression profile that is characteristic ofthe state ofthe cell. That is, normal tissue (e.g., normal ovarian or other tissue) may be distinguished from cancerous or metastatic cancerous tissue ofthe ovarian, or ovarian cancer tissue or metastatic ovarian cancerous tissue can be compared with tissue samples of ovarian and other tissues from surviving cancer patients. By comparing expression profiles of tissue in known different ovarian cancer states, information regarding which genes are important (including both up- and down-regulation of genes) in each of these states is obtained. Molecular profiling may distinguish subtypes of a cunently collective disease designation, e.g., different forms of a cancer.

The identification of sequences that are differentially expressed in ovarian cancer versus non-ovarian cancer tissue allows the use of this information in a number of ways. For example, a particular treatment regime may be evaluated: does a chemofherapeutic drug act to down-regulate ovarian cancer, and thus tumor growth or recunence, in a particular patient. Alternatively, does existing treatment induce expression of a target. Similarly, diagnosis and treatment outcomes may be done or confirmed by comparing patient samples with the known expression profiles. Metastatic tissue can also be analyzed to determine the stage of ovarian cancer in the tissue or origin ofthe primary tumor. Furthermore, these gene expression profiles (or individual genes) allow screening of drug candidates with an eye to mimicking or altering a particular expression profile; e.g., screening can be done for drugs that suppress the ovarian cancer expression profile. This may be done by making biochips comprising sets of the important ovarian cancer genes, which can then be used in these screens. These methods can also be based on evaluating protein expression; that is, protein expression levels ofthe ovarian cancer proteins can be evaluated for diagnostic purposes or to screen candidate agents. In addition, the ovarian cancer nucleic acid sequences can be administered for gene therapy purposes, including the administration of antisense or RNAi nucleic acids, or the ovarian cancer proteins (including antibodies and other modulators thereof) administered as therapeutic drugs.

Thus the present invention provides nucleic acid and protein sequences that are differentially expressed in ovarian cancer relative to normal tissues and/or non-malignant tissues, herein termed "ovarian cancer sequences." As outlined below, ovarian cancer sequences include those that are up-regulated (e.g., expressed at a higher level) in ovarian cancer, as well as those that are down-regulated (e.g., expressed at a lower level). In a prefened embodiment, the ovarian cancer sequences are from humans; however, as will be appreciated by those in the art, ovarian cancer sequences from other organisms may be useful in animal models of disease and drug evaluation; thus, other ovarian cancer sequences are provided, from vertebrates, including mammals, including rodents (rats, mice, hamsters, guinea pigs, etc.), primates, farm animals (including sheep, goats, pigs, cows, horses, etc.) and pets (e.g., dogs, cats, etc.). Ovarian cancer sequences, e.g., counterpart genes, from other organisms may be obtained using the techniques outlined below.

Ovarian cancer sequences can include both nucleic acid and amino acid sequences. Ovarian cancer nucleic acid sequences are useful in a variety of applications, including diagnostic applications, which will detect naturally occurring nucleic acids. Screening applications; e.g., biochips comprising nucleic acid probes or PCR microtiter plates with selected probes to the ovarian cancer sequences, are also provided.

An ovarian cancer sequence can be initially identified by substantial nucleic acid and/or amino acid sequence homology to the ovarian cancer sequences outlined herein. Such homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, using either homology programs or hybridization conditions.

For identifying ovarian cancer-associated sequences, the ovarian cancer screen typically includes comparing genes identified in different tissues, e.g., normal and cancerous tissues, or tumor tissue samples from patients who have metastatic disease vs. non metastatic tissue. Other suitable tissue comparisons include comparing ovarian cancer samples with metastatic cancer samples from other cancers, such as lung, ovarian, gastrointestinal cancers, etc. Samples of different stages of ovarian cancer, e.g., survivor tissue, drug resistant states, and tissue undergoing metastasis, are applied to biochips comprising nucleic acid probes. The samples are first microdissected, if applicable, and treated for the preparation of mRNA. Suitable biochips are commercially available, e.g., from Affymetrix. Gene expression profiles as described herein are generated and the data analyzed.

In one embodiment, the genes showing changes in expression as between normal and disease states are compared to genes expressed in other normal tissues, preferably normal ovarian, but also including, and not limited to, lung, heart, brain, liver, ovarian, kidney, muscle, colon, small intestine, large intestine, spleen, bone, and/or placenta. In a prefened embodiment, those genes identified during the ovarian cancer screen that are expressed in any significant amount in other tissues are removed from the profile, although in some embodiments, expression in non-essential tissues may be tolerated. That is, when screening for drugs, it is usually preferable that the target be disease specific, to minimize possible side effects by interaction with target present in other organs.

In a prefened embodiment, ovarian cancer sequences are those that are up-regulated in ovarian cancer; that is, the expression of these genes is higher in the ovarian cancer tissue as compared to non-cancerous tissue. "Up-regulation" as used herein often means at least about a two-fold change, preferably at least about a three fold change, with at least about five-fold or higher being prefened. Other embodiments are directed to sequences up regulated in non-malignant conditions relative to normal.

Unigene cluster identification numbers and accession numbers herein refer to the GenBank sequence database and the sequences ofthe accession numbers are hereby expressly incorporated by reference. GenBank is known in the art, see, e.g., Benson, et al. (1998) Nucl. Acids Res. 26:1-7; and http://www.ncbi.nlm.nih.gov/. Sequences are also available in other databases, e.g., European Molecular Biology Laboratory (EMBL) and DNA Database of Japan (DDBJ). In some situations, the sequences may be derived from assembly of available sequences or be predicted from genomic DNA using exon prediction algorithms, e.g., FGENESH. See Salamov and Solovyev (2000) Genome Res. 10:516-522. In other situations, sequences have been derived from cloning and sequencing of isolated nucleic acids.

In another prefened embodiment, ovarian cancer sequences are those that are down- regulated in ovarian cancer; that is, the expression of these genes is lower in ovarian cancer tissue as compared to non-cancerous tissue. "Down-regulation" as used herein often means at least about a two-fold change, preferably at least about a three-fold change, with at least about five-fold or higher being prefened.

Informatics The ability to identify genes that are over or under expressed in ovarian cancer can additionally provide high-resolution, high-sensitivity datasets which can be used in the areas of diagnostics, therapeutics, drug development, pharmacogenetics, protein structure, biosensor development, and other related areas. Expression profiles can be used in diagnostic or prognostic evaluation of patients with ovarian cancer. Subcellular toxicological information can be generated to better direct drug structure and activity conelation (see

Anderson (June 11-12, 1998) Pharmaceutical Proteomics: Targets, Mechanism, and Function. paper presented at the IBC Proteomics conference, Coronado, CA) or in a biological sensor device to predict the likely toxicological effect of chemical exposures and likely tolerable exposure thresholds (see U.S. Patent No. 5,811,231). Similar advantages accrue from datasets relevant to other biomolecules and bioactive agents (e.g., nucleic acids, saccharides, lipids, drugs, and the like).

Thus, in another embodiment, the present invention provides a database that includes at least one set of assay data. The data contained in the database is acquired, e.g., using anay analysis either singly or in a library format. The database can be in a form in which data can be maintained and transmitted, but is preferably an electronic database, and can be maintained on any electronic device allowing for the storage of and access to the database, such as a personal computer, but is preferably distributed on a wide area network, such as the World Wide Web.

The focus ofthe present section on databases that include peptide sequence data is for clarity of illustration only. It will be apparent to those of skill in the art that similar databases can be assembled for any assay data acquired using an assay ofthe invention.

The compositions and methods for identifying and/or quantitating the relative and/or absolute abundance of a variety of molecular and macromolecular species from a biological sample undergoing ovarian cancer, e.g., the identification of ovarian cancer-associated sequences described herein, provide an abundance of information which can be conelated with pathological conditions, predisposition to disease, drug testing, therapeutic monitoring, gene-disease causal linkages, identification of conelates of immunity and physiological status, and outcome data, among others. Although data generated from the assays ofthe invention is suited for manual review and analysis, in a prefened embodiment, data processing using high-speed computers is utilized.

An anay of methods for indexing and retrieving biomolecular information is known in the art. For example, U.S. Patents 6,023,659 and 5,966,712 disclose a relational database system for storing biomolecular sequence information in a manner that allows sequences to be catalogued and searched according to one or more protein function hierarchies. U.S. Patent 5,953,727 discloses a relational database having sequence records containing information in a format that allows a collection of partial-length DNA sequences to be catalogued and searched according to association with one or more sequencing projects for obtaining full-length sequences from the collection of partial length sequences. U.S. Patent

5,706,498 discloses a gene database retrieval system for making a retrieval of a gene sequence similar to a sequence data item in a gene database based on the degree of similarity between a key sequence and a target sequence. U.S. Patent 5,538,897 discloses a method using mass spectroscopy fragmentation patterns of peptides to identify amino acid sequences in computer databases by comparison of predicted mass spectra with experimentally-derived mass spectra using a closeness-of-fit measure. U.S. Patent 5,926,818 discloses a multidimensional database comprising a functionality for multi-dimensional data analysis described as on-line analytical processing (OLAP), which entails the consolidation of projected and actual data according to more than one consolidation path or dimension. U.S. Patent 5,295,261 reports a hybrid database structure in which the fields of each database record are divided into two classes, navigational and informational data, with navigational fields stored in a hierarchical topological map which can be viewed as a tree structure or as the merger of two or more such tree structures.

Fundamentals of bioinformatics are provided, e.g., in Mount, et al. (2001) Bioinformatics: Sequence and Genome Analysis CSH Press, NY; Durbin, et al. (eds. 1999) Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids Cambridge Univ. Press; Baxevanis and Oeullette (eds. 1998) Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins (2d ed.) Wiley-Liss; Rashidi and Buehler (1999) Bioinformatics: Basic Applications in Biological Science and Medicine CRC Press; Setubal, et al. (eds 1997) Introduction to Computational Molecular Biology Brooks/Cole; Misener and Krawetz (eds. 2000) Bioinformatics: Methods and Protocols Humana Press; Higgins and Taylor (eds. 2000) Bioinformatics: Sequence, Structure, and Databanks: A Practical Approach Oxford Univ. Press; Brown (2001) Bioinformatics: A Biologist's Guide to

Biocomputing and the Internet Eaton Pub.; Han and Kamber (2000) Data Mining: Concepts and Techniques Kaufmann Pub.; and Waterman (1995) ntroduction to Computational Biology: Maps, Sequences, and Genomes Chap and Hall.

The present invention provides a computer database comprising a computer and software for storing in computer-retrievable form assay data records cross-tabulated, e.g., with data specifying the source ofthe target-containing sample from which each sequence specificity record was obtained.

In an exemplary embodiment, at least one ofthe sources of target-containing sample is from a control tissue sample known to be free of pathological disorders. In a variation, at least one ofthe sources is a known pathological tissue specimen, e.g., a neoplastic lesion or another tissue specimen to be analyzed for ovarian cancer. In another variation, assay records cross-tabulate one or more ofthe following parameters for a target species in a sample: (1) a unique identification code, which can include, e.g., a target molecular structure and/or characteristic separation coordinate (e.g., electrophoretic or genomic position coordinates); (2) sample source; and (3) absolute and/or relative quantity of target species present in the sample.

The invention also provides for the storage and retrieval of a collection of target data in a computer data storage apparatus, which can include magnetic disks, optical disks, magneto-optical disks, DRAM, SRAM, SGRAM, SDRAM, RDRAM, DDR RAM, magnetic bubble memory devices, and other data storage devices, including CPU registers and on-CPU data storage anays. Typically, the target data records are stored as a bit pattern in an anay of magnetic domains on a magnetizable medium or as an anay of charge states or transistor gate states, such as an anay of cells in a DRAM device (e.g., each cell comprised of a transistor and a charge storage area, which may be on the transistor). In one embodiment, the invention provides such storage devices, and computer systems built therewith, comprising a bit pattern encoding a protein expression fingerprint record comprising unique identifiers for at least 10 target data records cross-tabulated with target source. When the target is a peptide or nucleic acid, the invention preferably provides a method for identifying related peptide or nucleic acid sequences, comprising performing a computerized comparison between a peptide or nucleic acid sequence assay record stored in or retrieved from a computer storage device or database and at least one other sequence. The comparison can include a sequence analysis or comparison algorithm or computer program embodiment thereof (e.g., FASTA, TFASTA, GAP, BESTFIT) and/or the comparison may be ofthe relative amount of a peptide or nucleic acid sequence in a pool of sequences determined from a polypeptide or nucleic acid sample of a specimen.

The invention also preferably provides a magnetic disk, such as an IBM-compatible (DOS, Windows, Windows95/98/2000, Windows NT, OS/2) or other format (e.g., Linux, SunOS, Solaris, ATX, SCO Unix, VMS, MV, Macintosh, etc.) floppy diskette or hard (fixed, Winchester) disk drive, comprising a bit pattern encoding data from an assay ofthe invention in a file format suitable for retrieval and processing in a computerized sequence analysis, comparison, or relative quantitation method.

The invention also provides a network, comprising a plurality of computing devices linked via a data link, such as an Ethernet cable (coax or lOBaseT), telephone line, ISDN line, wireless network, optical fiber, or other suitable signal transmission medium, whereby at least one network device (e.g., computer, disk array, etc.) comprises a pattern of magnetic domains (e.g., magnetic disk) and/or charge domains (e.g., an anay of DRAM cells) composing a bit pattern encoding data acquired from an assay ofthe invention.

The invention also provides a method for transmitting assay data that includes generating an electronic signal on an electronic communications device, such as a modem, ISDN terminal adapter, DSL, cable modem, ATM switch, or the like, wherein the signal includes (in native or encrypted format) a bit pattern encoding data from an assay or a database comprising a plurality of assay results obtained by the method ofthe invention.

In a prefened embodiment, the invention provides a computer system for comparing a query target to a database containing an anay of data structures, such as an assay result obtained by the method ofthe invention, and ranking database targets based on the degree of identity and gap weight to the. target data. A central processor is preferably initialized to load and execute the computer program for alignment and/or comparison ofthe assay results. Data for a query target is entered into the central processor via an I/O device. Execution of the computer program results in the central processor retrieving the assay data from the data file, which comprises a binary description of an assay result. The target data or record and the computer program can be transfened to secondary memory, which is typically random access memory (e.g., DRAM, SRAM, SGRAM, or SDRAM). Targets are ranked according to the degree of conespondence between a selected assay characteristic (e.g., binding to a selected affinity moiety) and the same characteristic of the query target and results are output via an I/O device. For example, a central processor can be a conventional computer (e.g., Intel Pentium, PowerPC, Alpha, PA-8000, SPARC, MIPS 4400, MIPS 10000, VAX, etc.); a program can be a commercial or public domain molecular biology software package (e.g., UWGCG Sequence Analysis Software, Darwin); a data file can be an optical or magnetic disk, a data server, a memory device (e.g., DRAM, SRAM, SGRAM, SDRAM, EPROM, bubble memory, flash memory, etc.); an I/O device can be a terminal comprising a video display and a keyboard, a modem, an ISDN terminal adapter, an Ethernet port, a punched card reader, a magnetic strip reader, or other suitable I/O device.

The invention also preferably provides the use of a computer system, e.g., which typically comprises one or more of: (1) a computer; (2) a stored bit pattern encoding a collection of peptide sequence specificity records obtained by methods ofthe inventions, which may be stored in the computer; (3) a comparison target, such as a query target; and (4) a program for alignment and comparison, typically with rank-ordering of comparison results on the basis of computed similarity values. Characteristics of ovarian cancer-associated proteins

Ovarian cancer proteins ofthe present invention maybe categorized as secreted proteins, transmembrane proteins, or intracellular proteins. In one embodiment, the ovarian cancer protein is an intracellular protein. Intracellular proteins may be found in the cytoplasm and/or in the nucleus. Intracellular proteins are involved in all aspects of cellular function and replication (including, e.g., signaling pathways); abenant expression of such proteins often results in unregulated or disregulated cellular processes. See, e.g., Alberts, et al. (eds. 1994) Molecular Biology ofthe Cell (3d ed.) Garland. For example, many intracellular proteins have enzymatic activity such as protein kinase activity, protein phosphatase activity, protease activity, nucleotide cyclase activity, polymerase activity, and the like, intracellular proteins can also serve as docking proteins that are involved in organizing complexes of proteins, or targeting proteins to various subcellular localizations, and are often involved in maintaining the structural integrity of organelles. An increasingly appreciated concept in characterizing proteins is the presence in the proteins of one or more structural motifs for which defined functions have been attributed. In addition to the highly conserved sequences found in the enzymatic domain of proteins, highly conserved sequences have been identified in proteins that are involved in protein- protein interaction. For example, Src-homology-2 (SH2) domains bind tyrosine- phosphorylated targets in a sequence dependent manner. PTB domains, which are distinct from SH2 domains, also bind tyrosine phosphorylated targets. SH3 domains bind to proline- rich targets. In addition, PH domains, tetratricopeptide repeats and WD domains to name only a few, have been shown to mediate protein-protein interactions. Some of these may also be involved in binding to phospholipids or other second messengers. As will be appreciated by one of ordinary skill in the art, these motifs can be identified on the basis of amino acid sequence; thus, an analysis ofthe sequence of proteins may provide insight into both the enzymatic potential ofthe molecule and/or molecules with which the protein may associate. One useful database is Pfam (protein families), which is a large collection of multiple sequence alignments and hidden Markov models covering many common protein domains. Versions are available via the internet from Washington University in St. Louis, the Sanger

Center in England, and the Karolinska Institute in Sweden. See, e.g., Bateman, et al. (2000)

Nuc. Acids Res. 28:263-266; Sonnhammer, et al. (1997) Proteins 28:405-420; Bateman, et al.

(1999) Nuc. Acids Res. 27:260-262; and Sonnhammer, et al. (1998) Nuc. Acids Res. 26:320- 322.

In another prefened embodiment, the ovarian cancer sequences are transmembrane proteins. Transmembrane proteins are molecules that span a phospholipid bilayer of a cell. They may have an intracellular domain, an extracellular domain, or both. The intracellular domains of such proteins may have a number of functions including those already described for intracellular proteins. For example, the intracellular domain may have enzymatic activity and/or may serve as a binding site for additional proteins. Frequently the intracellular domain of transmembrane proteins serves both roles. For example certain receptor tyrosine kinases have both protein kinase activity and SH2 domains. In addition, autophosphorylation of tyrosines on the receptor molecule itself, creates binding sites for additional SH2 domain containing proteins.

Transmembrane proteins may contain from one to many transmembrane domains. For example, receptor tyrosine kinases, certain cytokine receptors, receptor guanylyl cyclases and receptor serine/threonine protein kinases contain a single transmembrane domain. However, various other proteins including channels and adenylyl cyclases contain numerous transmembrane domains. Many important cell surface receptors such as G protein coupled receptors (GPCRs) are classified as "seven transmembrane domain" proteins, as they contain 7 membrane spanning regions. Characteristics of transmembrane domains include approximately 17 consecutive hydrophobic amino acids that maybe followed by charged amino acids. Therefore, upon analysis ofthe amino acid sequence of a particular protein, the localization and number of transmembrane domains within the protein may be predicted (see, e.g., PSORT web site http://psort.nibb.ac.jp/). Important transmembrane protein receptors include, but are not limited to the insulin receptor, insulin-like growth factor receptor, human growth hormone receptor, glucose transporters, transferrin receptor, epidermal growth factor receptor, low density lipoprotein receptor, epidermal growth factor receptor, leptin receptor, interleukin receptors, e.g., IL-1 receptor, IL-2 receptor, etc.

The extracellular domains of transmembrane proteins are diverse; however, conserved motifs are found repeatedly among various extracellular domains. Conserved structure and/or functions have been ascribed to different extracellular motifs. Many extracellular domains are involved in binding to other molecules. In one aspect, extracellular domains are found on receptors. Factors that bind the receptor domain include circulating ligands, which may be peptides, proteins, or small molecules such as adenosine and the like. For example, growth factors such as EGF, FGF, and PDGF are circulating growth factors that bind to their cognate receptors to initiate a variety of cellular responses. Other factors include cytokines, mitogenic factors, neurotrophic factors and the like. Extracellular domains also bind to cell- associated molecules, or may be processed or shed to the blood stream. In this respect, they can mediate cell-cell interactions. Cell-associated ligands can be tethered to the cell, e.g., via a glycosylphosphatidylinositol (GPI) anchor, or may themselves be transmembrane proteins. Extracellular domains also associate with the extracellular matrix and contribute to the maintenance ofthe cell structure.

Ovarian cancer proteins that are transmembrane are particularly prefened in the present invention as they are readily accessible targets for immunotherapeutics, as are described herein. In addition as outlined below, transmembrane proteins can be also useful in imaging modalities. Antibodies may be used to label such readily accessible proteins in situ. Alternatively, antibodies can also label intracellular proteins, in which case samples are typically permeablized to provide access to intracellular proteins. In addition, some membrane proteins can be processed to release a soluble protein, or to expose a residual fragment. Released soluble proteins may be useful diagnostic markers, processed residual protein fragments maybe useful ovarian markers of disease.

It will also be appreciated by those in the art that a transmembrane protein can be made soluble by removing transmembrane sequences, e.g., through recombinant methods. Furthermore, transmembrane proteins that have been made soluble can be made to be secreted through recombinant means by adding an appropriate signal sequence.

In another embodiment, the ovarian cancer proteins are secreted proteins; the secretion of which can be either constitutive or regulated. These proteins may have a signal peptide or signal sequence that targets the molecule to the secretory pathway. Secreted proteins are involved in numerous physiological events; e.g., if circulating, they often serve to transmit signals to various other cell types. The secreted protein may function in an autocrine manner (acting on the cell that secreted the factor), a paracrine manner (acting on cells in close proximity to the cell that secreted the factor), an endocrine manner (acting on cells at a distance, e.g., secretion into the blood stream), or exocrine (secretion, e.g., through a duct or to an adjacent epithelial surface as sweat glands, sebaceous glands, pancreatic ducts, lacrimal glands, mammary glands, wax producing glands ofthe ear, etc.). Thus, secreted molecules often find use in modulating or altering numerous aspects of physiology. Ovarian cancer proteins that are secreted proteins are particularly prefened as good diagnostic markers, e.g., for blood, plasma, serum, or stool tests. Those which are enzymes may be antibody or small molecule therapeutic targets. Others may be useful as vaccine targets, e.g., via CTL mechanisms, as protein or DNA vaccines.

Use of ovarian cancer nucleic acids As described above, ovarian cancer sequence is initially identified by substantial nucleic acid and/or amino acid sequence homology or linkage to the ovarian cancer sequences outlined herein. Such homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, using either homology programs or hybridization conditions. Typically, linked sequences on a mRNA are found on the same molecule.

The ovarian cancer nucleic acid sequences ofthe invention, e.g., in Table 1-26, can be fragments of larger genes, e.g., they are nucleic acid segments. "Genes" in this context includes coding regions, non-coding regions, and mixtures of coding and non-coding regions. Accordingly, as will be appreciated by those in the art, using the sequences provided herein, extended sequences, in either direction, ofthe ovarian cancer genes can be obtained, using techniques well known in the art for cloning either longer sequences or the full length sequences; see Ausubel, et al., supra. Much can be done by informatics and many sequences can be clustered to include multiple sequences conesponding to a single gene, e.g., systems such as UniGene (see, http://www.ncbi.nlm.nih.gov/UniGene/). Once the ovarian cancer nucleic acid is identified, it can be cloned and, if necessary, its constituent parts recombined to form the entire ovarian cancer nucleic acid coding regions or the entire mRNA sequence. Once isolated from its natural source, e.g., contained within a plasmid or other vector or excised as a linear nucleic acid segment, the recombinant ovarian cancer nucleic acid can be further-used as a probe to identify and isolate other ovarian cancer nucleic acids, e.g., extended coding regions. It can also be used as a "precursor" nucleic acid to make modified or variant ovarian cancer nucleic acids and proteins.

The ovarian cancer nucleic acids ofthe present invention are useful in several ways. In a first embodiment, nucleic acid probes to the ovarian cancer nucleic acids are made and attached to biochips to be used in screening and diagnostic methods, as outlined below, or for administration, e.g., for gene therapy, vaccine, RNAi, and/or antisense applications.

Alternatively, the ovarian cancer nucleic acids that include coding regions of ovarian cancer proteins can be put into expression vectors for the expression of ovarian cancer proteins, again for screening purposes or for administration to a patient. In a prefened embodiment, nucleic acid probes to ovarian cancer nucleic acids (both the nucleic acid sequences outlined in the figures and/or the complements thereof) are made. The nucleic acid probes attached to the biochip are designed to be substantially complementary to the ovarian cancer nucleic acids, e.g., the target sequence (either the target sequence ofthe sample or to other probe sequences, e.g., in sandwich assays), such that hybridization ofthe target sequence and the probes ofthe present invention occurs. As outlined below, this complementarity need not be perfect; there may be any number of base pair mismatches which will interfere with hybridization between the target sequence and the single stranded nucleic acids ofthe present invention. However, if the number of mutations is so great that no hybridization can occur under even the least stringent of hybridization conditions, the sequence is not a complementary target sequence. Thus, by "substantially complementary" herein is meant that the probes are sufficiently complementary to the target sequences to hybridize under normal reaction conditions, particularly high stringency conditions, as outlined herein. A nucleic acid probe is generally single stranded but can be partially single and partially double stranded. The strandedness ofthe probe is dictated by the structure, composition, and properties ofthe target sequence. In general, the nucleic acid probes range from about 8 to about 100 bases long, with from about 10 to about 80 bases being prefened, and from about 30 to about 50 bases being particularly prefened. That is, generally whole genes are not used. In some embodiments, much longer nucleic acids can be used, up to hundreds of bases.

In a prefened embodiment, more than one probe per sequence is used, with either overlapping probes or probes to different sections ofthe target being used. That is, two, three, four or more probes, with three being prefened, are used to build in a redundancy for a particular target. The probes can be overlapping (e.g., have some sequence in common), or separate. In some cases, PCR primers may be used to amplify signal for higher sensitivity.

As will be appreciated by those in the art, nucleic acids can be attached or immobilized to a solid support in a wide variety of ways. By "immobilized" and grammatical equivalents herein is meant the association or binding between the nucleic acid probe and the solid support is sufficient to be stable under the conditions of binding, washing, analysis, and removal as outlined below. The binding can typically be covalent or non-covalent. By "non- covalent binding" and grammatical equivalents herein is meant one or more of electrostatic, hydrophiiic, and hydrophobic interactions. Included in non-covalent binding is the covalent attachment of a molecule, such as, streptavidin to the support and the non-covalent binding of the biotinylated probe to the streptavidin. By "covalent binding" and grammatical^" equivalents herein is meant that the two moieties, the solid support and the probe, are attached by at least one bond, including sigma bonds, pi bonds and coordination bonds. Covalent bonds can be formed directly between the probe and the solid support or can be formed by a cross linker or by inclusion of a specific reactive group on either the solid support or the probe or both molecules, immobilization may also involve a combination of covalent and non-covalent interactions.

In general, the probes are attached to the biochip in a wide variety of ways, as will be appreciated by those in the art. As described herein, the nucleic acids can either be synthesized first, with subsequent attachment to the biochip, or can be directly synthesized on the biochip.

The biochip comprises a suitable solid substrate. By "substrate" or "solid support" or other grammatical equivalents herein is meant a material that can be modified to contain discrete individual sites appropriate for the attachment or association ofthe nucleic acid probes and is amenable to at least one detection method. As will be appreciated by those in the art, the number of possible substrates are very large, and include, but are not limited to, glass and modified or functionalized glass, plastics (including acrylics, polystyrene and copolymers of styrene and other materials, polypropylene, polyethylene, polybutylene, polyurethanes, TeflonJ, etc.), polysaccharides, nylon or nitrocellulose, resins, silica or silica- based materials including silicon and modified silicon, carbon, metals, inorganic glasses, plastics, etc. In general, the substrates allow optical detection and do not appreciably fluoresce. See, e.g., WO0055627 Reusable Low Fluorescent Plastic Biochip.

Generally the substrate is planar, although as will be appreciated by those in the art, other configurations of substrates may be used as well. For example, the probes may be placed on the inside surface of a tube, for flow-through sample analysis to minimize sample volume. Similarly, the substrate may be flexible, such as a flexible foam, including closed cell foams made of particular plastics.

In a prefened embodiment, the surface ofthe biochip and the probe may be derivatized with chemical functional groups for subsequent attachment ofthe two. Thus, e.g., the biochip is derivatized with a chemical functional group including, but not limited to, amino groups, carboxyl groups, oxo groups and thiol groups, with amino groups being particularly prefened. Using these functional groups, the probes can be attached using functional groups on the probes. For example, nucleic acids containing amino groups can be attached to surfaces comprising amino groups, e.g., using linkers as are known in the art; e.g., homo-or hetero-bifunctional linkers as are well known (see 1994 Pierce Chemical Company catalog, technical section on cross-linkers, pages 155-200). In addition, in some cases, additional linkers, such as alkyl groups (including substituted and heteroalkyl groups) may be used.

In this embodiment, oligonucleotides are synthesized as is known in the art, and then attached to the surface ofthe solid support. As will be appreciated by those skilled in the art, either the 5' or 3' terminus may be attached to the solid support, or attachment may be via an internal nucleoside.

In another embodiment, the immobilization to the solid support may be very strong, yet non-covalent. For example, biotinylated oligonucleotides can be made, which bind to surfaces covalently coated with streptavidin, resulting in attachment.

Alternatively, the oligonucleotides may be synthesized on the surface, as is known in the art. For example, photoactivation techniques utilizing photopolymerization compounds and techniques are used. In a prefened embodiment, the nucleic acids can be synthesized in situ, using well known photolithographic techniques, such as those described in WO 95/25116; WO 95/35505; U.S. Patent Nos. 5,700,637 and 5,445,934; and references cited within, all of which are expressly incorporated by reference; these methods of attachment form the basis ofthe Affymetrix GeneChip™ technology.

Often, amplification-based assays are performed to measure the expression level of ovarian cancer-associated sequences. These assays are typically performed in conjunction with reverse transcription. In such assays, an ovarian cancer-associated nucleic acid sequence acts as a template in an amplification reaction (e.g., Polymerase Chain Reaction, or PCR). In a quantitative amplification, the amount of amplification product will be proportional to the amount of template in the original sample. Comparison to appropriate controls provides a measure ofthe amount of ovarian cancer-associated RNA. Methods of quantitative amplification are well known to those of skill in the art. Detailed protocols for quantitative PCR are available. See, e.g., Innis, et al.(1990) PCR Protocols: A Guide to Methods and Applications Academic Press.

In some embodiments, a TaqMan based assay is used to measure expression.

TaqMan based assays use a fluorogenic oligonucleotide probe that contains a 5' fluorescent dye and a 3' quenching agent. The probe hybridizes to a PCR product, but cannot itself be extended due to a blocking agent at the 3' end. When the PCR product is amplified in subsequent cycles, the 5' nuclease activity ofthe polymerase, e.g., AmpliTaq, results in the cleavage ofthe TaqMan probe. This cleavage separates the 5' fluorescent dye and the 3' quenching agent, thereby resulting in an increase in fluorescence as a function of amplification (see, e.g., literature provided by Perkin-Elmer, e.g., www2.perkin-elmer.com). Other suitable amplification methods include, but are not limited to, ligase chain reaction (LCR; see Wu and Wallace (1989) Genomics 4:560-569; Landegren, et al. (1988) Science 241:1077-1980; and Barringer, et al. (1990) Gene 89:117-122), transcription amplification (Kwoh, et al. (1989) Proc. Nat'l Acad. Sci. USA 86:1173-1177), self-sustained sequence replication (Guatelli, et al. (1990) Proc. Nat'l Acad. Sci. USA 87: 1874-1878), dot PCR, linker adapter PCR, etc.

Expression of ovarian cancer proteins from nucleic acids

In a prefened embodiment, ovarian cancer nucleic acids, e.g., encoding ovarian cancer proteins are used to make a variety of expression vectors to express ovarian cancer proteins which can then be used in screening assays, as described below. Expression vectors and recombinant DNA technology are well known and are used to express proteins. See, e.g., Ausubel, supra; and Fernandez and Hoeffler (eds. 1999) Gene Expression Systems Academic Press. The expression vectors may be either self-replicating extrachromosomal vectors or vectors which integrate into a host genome. Generally, these expression vectors include transcriptional and translational regulatory nucleic acid operably linked to the nucleic acid encoding the ovarian cancer protein. The term "control sequences" refers to DNA sequences used for the expression of an operably linked coding sequence in a particular host organism. Control sequences that are suitable for prokaryotes, e.g., include a promoter, optionally an operator sequence, and a ribosome binding site. Eukaryotic cells are known to utilize promoters, polyadenylation signals, and enhancers.

Nucleic acid is "operably linked" when it is placed into a functional relationship with another nucleic acid sequence. For example, DNA for a pre-sequence or secretory leader is operably linked to DNA for a polypeptide if it is expressed as a pre-protein that participates in the secretion ofthe polypeptide; a promoter or enhancer is operably linked to a coding sequence if it affects the transcription ofthe sequence; a ribosome binding site is operably linked to a coding sequence if it is positioned so as to facilitate translation; and two sequences may be operably linked when they are physically part ofthe same polymer. Generally, "operably linked" means that the DNA sequences being linked are contiguous, and, in the case of a secretory leader, contiguous and in reading phase. However, enhancers do not have to be contiguous. Linking is typically accomplished by ligation at convenient restriction sites. If such sites do not exist, synthetic oligonucleotide adaptors or linkers are used in accordance with conventional practice. Transcriptional and translational regulatory nucleic acid will generally be appropriate to the host cell used to express the ovarian cancer protein. Numerous types of appropriate expression vectors, and suitable regulatory sequences are known in the art for a variety of host cells.

In general, transcriptional and translational regulatory sequences may include, but are not limited to, promoter sequences, ribosomal binding sites, transcriptional start and stop sequences, translational start and stop sequences, and enhancer or activator sequences. In a prefened embodiment, the regulatory sequences include a promoter and transcriptional start and stop sequences.

Promoter sequences typically encode constitutive or inducible promoters. The promoters may be naturally occurring promoters or hybrid promoters. Hybrid promoters, which combine elements of more than one promoter, are also known in the art, and are useful in the present invention.

In addition, an expression vector may comprise additional elements. For example, the expression vector may have two replication systems, thus allowing it to be maintained in two organisms, e.g., in mammalian or insect cells for expression and in a procaryotic host for cloning and amplification. Furthermore, for integrating expression vectors, the expression vector contains at least one sequence homologous to the host cell genome, and preferably two homologous sequences which flank the expression construct. The integrating vector may be directed to a specific locus in the host cell by selecting the appropriate homologous sequence for inclusion in the vector. Constructs for integrating vectors are available. See, e.g., Fernandez and Hoeffler, supra.

In addition, in a prefened embodiment, the expression vector contains a selectable marker gene to allow the selection of transformed host cells. Selection genes are well known in the art and will vary with the host cell used. The ovarian cancer proteins ofthe present invention are produced by culturing a host cell transformed with an expression vector containing nucleic acid encoding an ovarian cancer protein, under the appropriate conditions to induce or cause expression ofthe ovarian cancer protein. Conditions appropriate for ovarian cancer protein expression will vary with the choice ofthe expression vector and the host cell, and will be easily ascertained by one skilled in the art through routine experimentation or optimization. For example, the use of constitutive promoters in the expression vector will require optimizing the growth and proliferation ofthe host cell, while the use of an inducible promoter requires the appropriate growth conditions for induction. In addition, in some embodiments, the timing ofthe harvest is important. For example, the baculovirus systems used in insect cell expression are lytic viruses, and thus harvest time selection can be crucial for product yield.

Appropriate host cells include yeast, bacteria, archaebacteria, fungi, and insect and animal cells, including mammalian cells. Of particular interest are Saccharomyces cerevisiae and other yeasts, E. coli, Bacillus subtilis, Sf9 cells, C129 cells, 293 cells, Neurospora, BHK, CHO, COS, HeLa cells, HUVEC (human umbilical vein endothelial cells), THP1 cells (a macrophage cell line) and various other human cells and cell lines.

In a prefened embodiment, the ovarian cancer proteins are expressed in mammalian cells. Mammalian expression systems are also known in the art, and include retroviral and adenoviral systems. One expression vector system is a retroviral vector system such as is generally described in PCT/US97/01019 and PCT/US97/01048, both of which are hereby expressly incorporated by reference. Of particular use as mammalian promoters are the promoters from mammalian viral genes, since the viral genes are often highly expressed and have a broad host range. Examples include the SV40 early promoter, mouse mammary tumor virus LTR promoter, adenovirus major late promoter, herpes simplex virus promoter, and the CMV promoter. See, e.g., Fernandez and Hoeffler, supra. Typically, transcription termination and polyadenylation sequences recognized by mammalian cells are regulatory regions located 3' to the translation stop codon and thus, together with the promoter elements, flank the coding sequence. Examples of transcription terminator and polyadenylation signals include those derived form SV40.

The methods of introducing exogenous nucleic acid into mammalian hosts, as well as other hosts, is well known in the art, and will vary with the host cell used. Techniques include dextran-mediated transfection, calcium phosphate precipitation, polybrene mediated transfection, protoplast fusion, electroporation, viral infection, encapsulation ofthe polynucleotide(s) in liposomes, and direct microinjection ofthe DNA into nuclei.

In a prefened embodiment, ovarian cancer proteins are expressed in bacterial systems. Bacterial expression systems are well known in the art. Promoters from bacteriophage may also be used and are known in the art. In addition, synthetic promoters and hybrid promoters are also useful; e.g., the tac promoter is a hybrid ofthe trp and lac promoter sequences. Furthermore, a bacterial promoter can include naturally occurring promoters of nofi-bacterial origin that have the ability to bind bacterial RNA polymerase and initiate transcription. In addition to a functioning promoter sequence, an efficient ribosome binding site is desirable. The expression vector may also include a signal peptide sequence that provides for secretion ofthe ovarian cancer protein in bacteria. The protein is either secreted into the growth media (gram-positive bacteria) or into the periplasmic space, located between the inner and outer membrane ofthe cell (gram-negative bacteria). The bacterial expression vector may also include a selectable marker gene to allow for the selection of bacterial strains that have been transformed. Suitable selection genes include genes which render the bacteria resistant to drugs such as ampicillin, chloramphenicol, erythromycin, kanamycin, neomycin, and tetracycline. Selectable markers also include biosynthetic genes, such as those in the histidine, tryptophan, and leucine biosynthetic pathways. These components are assembled into expression vectors. Expression vectors for bacteria are well known in the art, and include vectors for Bacillus subtilis, E. coli, Streptococcus cremoris, and Streptococcus lividans, among others. See Fernandez and Hoeffler, supra. The bacterial expression vectors are transformed into bacterial host cells using techniques well known in the art, such as calcium chloride treatment, electroporation, and others.

In one embodiment, ovarian cancer proteins are produced in insect cells. Expression vectors for the transformation of insect cells, and in particular, baculo virus-based expression vectors, are well known in the art.

In a prefened embodiment, an ovarian cancer protein is produced in yeast cells. Yeast expression systems are well known in the art, and include expression vectors for Saccharomyces cerevisiae, Candida albicans and C. maltosa, Hansenula polymorpha, Kluyveromyces fragilis and K. lactis, Pichia guillerimondii and P. pastoris, Schizosaccharomyces pombe, and Yanowia lipolytica.

The ovarian cancer protein may also be made as a fusion protein, using techniques well known in the art. Thus, e.g., for the creation of monoclonal antibodies, if the desired epitope is small, the ovarian cancer protein may be fused to a carrier protein to form an immunogen. Alternatively, the ovarian cancer protein may be made as a fusion protein to increase expression, or for other reasons. For example, when the ovarian cancer protein is an ovarian cancer peptide, the nucleic acid encoding the peptide may be linked to other nucleic acid for expression purposes. In a prefened embodiment, the ovarian cancer protein is purified or isolated after expression. Ovarian cancer proteins may be isolated or purified in a variety of ways known to those skilled in the art depending on what other components are present in the sample. Standard purification methods include electrophoretic, molecular, immunological and chromatographic techniques, including ion exchange, hydrophobic, affinity, and reverse- phase HPLC chromatography, and chromatofocusing. For example, the ovarian cancer protein may be purified using a standard anti-ovarian cancer protein antibody column. Ultrafiltration and diafiltration techniques, in conjunction with protein concentration, are also useful. For general guidance in suitable purification techniques, see Scopes (1982) Protein Purification Springer- Verlag. The degree of purification necessary will vary depending on the use ofthe ovarian cancer protein. In some instances no purification will be necessary. Once expressed and purified if necessary, the ovarian cancer proteins and nucleic acids are useful in a number of applications. They may be used as immunoselection reagents, as vaccine reagents, as screening agents, etc.

Variants of ovarian cancer proteins

In one embodiment, the ovarian cancer proteins are derivative or variant ovarian cancer proteins as compared to the wild-type sequence. That is, as outlined more fully below, the derivative ovarian cancer peptide will often contain at least one amino acid substitution, deletion or insertion, with amino acid substitutions being particularly prefened. The amino acid substitution, insertion, or deletion may occur at most any residue within the ovarian cancer peptide.

Also included within one embodiment of ovarian cancer proteins ofthe present invention are amino acid sequence variants. These variants typically fall into one or more of three classes: substitutional, insertional or deletional variants. These variants ordinarily are prepared by site specific mutagenesis of nucleotides in the DNA encoding the ovarian cancer protein, using cassette or PCR mutagenesis or other techniques. well known in the art, to produce DNA encoding the variant, and thereafter expressing the DNA in recombinant cell culture as outlined above. However, variant ovarian cancer protein fragments having up to about 100-150 residues may be prepared by in vitro synthesis using established techniques.

Amino acid sequence variants are characterized by the predetermined nature ofthe variation, a feature that sets them apart from naturally occurring allelic or interspecies variation ofthe ovarian cancer protein, amino acid sequence. The variants typically exhibit the same qualitative biological activity as the naturally occurring analogue, although variants can also be selected which have modified characteristics as will be more fully outlined below.

While the site or region for introducing an amino acid sequence variation is predetermined, the mutation per se need not be predetermined. For example, in order to optimize the performance of a mutation at a given site, random mutagenesis may be conducted at the target codon or region and the expressed ovarian cancer variants screened for the optimal combination of desired activity. Techniques for making substitution mutations at predetermined sites in DNA having a known sequence are well known, e.g., M13 primer mutagenesis and PCR mutagenesis. Screening ofthe mutants is done using assays of ovarian cancer protein activities.

Amino acid substitutions are typically of single residues; insertions usually will be on the order of from about 1 to 20 amino acids, although considerably larger insertions may be tolerated. Deletions range from about 1 to about 20 residues, although in some cases deletions may be much larger. Substitutions, deletions, insertions or any combination thereof may be used to arrive at a final derivative. Generally these changes are done on a few amino acids to minimize the alteration ofthe molecule. However, larger changes may be tolerated in certain circumstances. When small alterations in the characteristics ofthe ovarian cancer protein are desired, substitutions are generally made in accordance with the amino acid substitution relationships provided in the definition section.

The variants typically exhibit the same qualitative biological activity and will elicit the same immune response as the naturally-occuning analog, although variants also are selected to modify the characteristics ofthe ovarian cancer proteins as needed. Alternatively, the variant may be designed such that the biological activity ofthe ovarian cancer protein is altered. For example, glycosylation sites may be altered or removed.

Substantial changes in function or immunological identity are made by selecting substitutions that are less conservative than those described above. For example, substitutions may be made which more significantly affect: the structure ofthe polypeptide backbone in the area ofthe alteration, for example the alpha-helical or beta-sheet structure; the charge or hydrophobicity ofthe molecule at the target site; or the bulk ofthe side chain.

The substitutions which in general are expected to produce the greatest changes in the polypeptide's properties are those in which (a) a hydrophilic residue, e.g., serine or threonine is substituted for (or by) a hydrophobic residue, e.g., leucine, isoleucine, phenylalanine, valine, or alanine; (b) a cysteine or proline is substituted for (or by) any other residue; (c) a residue having an electropositive side chain, e.g., lysine, arginine, or histidine, is substituted for (or by) an electronegative residue, e.g., glutamic or aspartic acid; (d) a residue having a bulky side chain, e.g., phenylalanine, is substituted for (or by) one not having a side chain, e.g., glycine; or (e) a proline residue is incorporated or substituted, which changes the degree of rotational freedom ofthe peptidyl bond.

Covalent modifications of ovarian cancer polypeptides are included within the scope of this invention. One type of covalent modification includes reacting targeted amino acid residues of an ovarian cancer polypeptide with an organic derivatizing agent that is capable of reacting with selected side chains or the N-or C-terminal residues of an ovarian cancer polypeptide. Derivatization with bifunctional agents is useful, for instance, for crosslinking ovarian cancer polypeptides to a water-insoluble support matrix or surface for use in the method for purifying anti-ovarian cancer polypeptide antibodies or screening assays, as is more fully described below. Commonly used crosslinking agents include, e.g., 1,1- bis(diazoacetyl)-2-phenylethane, glutaraldehyde, N-hydroxysuccinimide esters, e.g., esters with 4-azidosalicylic acid, homobifunctional imidoesters, including disuccinimidyl esters such as 3,3'-dithiobis(succinimidylpropionate), bifunctional maleimides such as bis-N- maleimido- 1,8 -octane and agents such as methyl-3-((p-azidophenyl)dithio)propioimidate.

Other modifications include deamidation of glutamine and asparagine residues to the conesponding glutamic and aspartic acid residues, respectively, hydroxylation of proline and lysine, phosphorylation of hydroxyl groups of serine, threonine, or tyrosine residues, methylation ofthe amino groups ofthe lysine, arginine, and histidine side chains (e.g., pp. 79-86, Creighton (1983) Proteins: Structure and Molecular Properties Freeman), acetylation ofthe N-terminal amine, and amidation of a C-terminal carboxyl group. Another type of covalent modification ofthe ovarian cancer polypeptide included within the scope of this invention comprises altering the native glycosylation pattern ofthe polypeptide. "Altering the native glycosylation pattern" is intended for purposes herein to mean deleting one or more carbohydrate moieties found in native sequence ovarian cancer polypeptide, and/or adding one or more glycosylation sites that are not present in the native sequence ovarian cancer polypeptide. Glycosylation patterns can be altered in many ways. For example the use of different cell types to express ovarian cancer-associated sequences can result in different glycosylation patterns.

Addition of glycosylation sites to ovarian cancer polypeptides may also be accomplished by altering the amino acid sequence thereof. The alteration may be made, e.g., by the addition of, or substitution by, one or more serine or threonine residues to the native sequence ovarian cancer polypeptide (for O-linked glycosylation sites). The ovarian cancer amino acid sequence may optionally be altered through changes at the DNA level, particularly by mutating the DNA encoding the ovarian cancer polypeptide at pre-selected bases such that codons are generated that will translate into the desired amino acids.

Another means of increasing the number of carbohydrate moieties on the ovarian cancer polypeptide is by chemical or enzymatic coupling of glycosides to the polypeptide. See, e.g., WO 87/05330, and pp. 259-306 in Aplin and Wriston (1981) CRC Crit. Rev. Biochem. CRC Press.

Removal of carbohydrate moieties present on the ovarian cancer polypeptide may be accomplished chemically or enzymatically or by mutational substitution of codons encoding for amino acid residues that serve as targets for glycosylation. Chemical deglycosylation techniques are applicable. See, e.g., Sojar and Bahl (1987) Arch. Biochem. Biophys. 259:52- 57: and Edge, et al. (1981) Anal. Biochem. 118:131-137. Enzymatic cleavage of carbohydrate moieties on polypeptides can be achieved by the use of a variety of endo-and exo-glycosidases. See, e.g., Thotakura, et al. (1987) Meth. Enzymol.. 138:350-359.

Another type of covalent modification of ovarian cancer comprises linking the ovarian cancer polypeptide to one of a variety of non-proteinaceous polymers, e.g., polyethylene glycol, polypropylene glycol, or polyoxyalkylene. See, e.g., U.S. Patent Nos. 4,640,835; 4,496,689; 4,301,144; 4,670,417; 4,791,192; or 4,179,337.

Ovarian cancer polypeptides ofthe present invention may also be modified in a way to form chimeric molecules, e.g., comprising an ovarian cancer polypeptide fused to another heterologous polypeptide or amino acid sequence. In one embodiment, such a chimeric molecule comprises a fusion of an ovarian cancer polypeptide with a tag polypeptide which provides an epitope to which an anti-tag antibody can selectively bind. The epitope tag is generally placed at the amino-or carboxyl-terminus ofthe ovarian cancer polypeptide. The presence of such epitope-tagged forms of an ovarian cancer polypeptide can be detected using an antibody against the tag polypeptide. Also, provision ofthe epitope tag enables the ovarian cancer polypeptide to be readily purified by affinity purification using an anti-tag antibody or another type of affinity matrix that binds to the epitope tag. In an alternative embodiment, the chimeric molecule may comprise a fusion of an ovarian cancer polypeptide with an immunoglobulin or a particular region of an immunoglobulin. For a bivalent form of the chimeric molecule, such a fusion could be to the Fc region of an IgG molecule.

Various tag polypeptides and their respective antibodies are well known in the art. Examples include poly-histidine (poly-his) or poly-histidine-glycine (poly-his-gly) tags; His6 and metal chelation tags, the flu HA tag polypeptide and its antibody 12CA5 (Field, et al. (1988) Mol. Cell. Biol. 8:2159-2165); the c-myc tag and the 8F9, 3C7, 6E10, G4, B7, and 9E10 antibodies thereto (Evan, et al. (1985) Mol. Cell. Biol. 5:3610-3616); and the Herpes Simplex virus glycoprotein D (gD) tag and its antibody (Paborsky, et al. (1990) Protein Engineering 3:547-553). Other tag polypeptides include, e.g., the Flag-peptide (Hopp, et al. (1988) BioTechnology 6:1204-1210); the KT3 epitope peptide (Martin, et al. (1992) Science 255:192-194); tubulin epitope peptide (Skinner, et al. (1991) J. Biol. Chem. 266:15163- 15166); and the T7 gene 10 protein peptide tag (Lutz-Freyermuth et al. (1990) Proc. Nat'l Acad. Sci. USA 87:6393-6397).

Also included are other ovarian cancer proteins ofthe ovarian cancer family, and ovarian cancer proteins from other organisms, which are cloned and expressed as outlined below. Thus, probe or degenerate polymerase chain reaction (PCR) primer sequences may be used to find other related ovarian cancer proteins from humans or other organisms. As will be appreciated by those in the art, particularly useful probe and/or PCR primer sequences include the unique areas ofthe ovarian cancer nucleic acid sequence. As is generally known in the art, prefened PCR primers are from about 15 to about 35 nucleotides in length, with from about 20 to about 30 being prefened, and may contain inosine as needed. The conditions for the PCR reaction are well known in the art (e.g., Innis, PCR Protocols, supra).

Antibodies to ovarian cancer proteins

In a prefened embodiment, when the ovarian cancer protein is to be used to generate antibodies, e.g., for immunotherapy or immunodiagnosis, the ovarian cancer protein should share at least one epitope or determinant with the full length protein. By "epitope" or

"determinant" herein is typically meant a portion of a protein which will generate and/or bind an antibody or T-cell receptor in the context of MHC. Thus, in most instances, antibodies made to a smaller ovarian cancer protein will be able to bind to the full-length protein, particularly linear epitopes. In a prefened embodiment, the epitope is unique; that is, antibodies generated to a unique epitope show little or no cross-reactivity.

Methods of preparing polyclonal antibodies are known to the skilled artisan (e.g.,

Coligan, supra; and Harlow and Lane, supra). Polyclonal antibodies can be raised in a mammal, e.g., by one or more injections of an immunizing agent and, if desired, an adjuvant. Typically, the immunizing agent and/or adjuvant will be injected in the mammal by multiple subcutaneous or intraperitoneal injections. The immunizing agent may include a protein encoded by a nucleic acid ofthe figures or fragment thereof or a fusion protein thereof. It may be useful to conjugate the immunizing agent to a protein known to be immunogenic in the mammal being immunized. Examples of such immunogenic proteins include but are not limited to keyhole limpet hemocyanin, serum albumin, bovine thyroglobulin, and soybean trypsin inhibitor. Examples of adjuvants which may be employed include Freund's complete adjuvant and MPL-TDM adjuvant (monophosphoryl Lipid A, synthetic trehalose dicorynomycolate). The immunization protocol may be selected by one skilled in the art without undue experimentation.

The antibodies may, alternatively, be monoclonal antibodies. Monoclonal antibodies may be prepared using hybridoma methods, such as those described by Kohler and Milstein (1975) Nature 256:495-497. In a hybridoma method, a mouse, hamster, or other appropriate host animal, is typically immunized with an immunizing agent to elicit lymphocytes that produce or are capable of producing antibodies that will specifically bind to the immunizing agent. Alternatively, the lymphocytes may be immunized in vitro. The immunizing agent will typically include a polypeptide encoded by a nucleic acid of Tables 1-26 or fragment thereof, or a fusion protein thereof. Generally, either peripheral blood lymphocytes ("PBLs") are used if cells of human origin are desired, or spleen cells or lymph node cells are used if non-human mammalian sources are desired. The lymphocytes are then fused with an immortalized cell line using a suitable fusing agent, such as polyethylene glycol, to form a hybridoma cell (e.g., pp. 59-103 in Goding (1986) Monoclonal Antibodies: Principles and Practice Academic Press). Immortalized cell lines are usually transformed mammalian cells, particularly myeloma cells of rodent, bovine and human origin. Usually, rat or mouse myeloma cell lines are employed. The hybridoma cells may be cultured in a suitable culture medium that preferably contains one or more substances that inhibit the growth or survival of the unfused, immortalized cells. For example, if the parental cells lack the enzyme hypoxanthine guanine phosphoribosyl transferase (HGPRT or HPRT), the culture medium for the hybridomas typically will include hypoxanthine, aminopterin, and thymidine ("HAT medium"), which substances prevent the growth of HGPRT-deficient cells.

In one embodiment, the antibodies are bispecific antibodies. Bispecific antibodies are monoclonal, preferably human or humanized, antibodies that have binding specificities for at least two different antigens or that have binding specificities for two epitopes on the same antigen. In one embodiment, one ofthe binding specificities is for a protein encoded by a nucleic acid Table 1-26 or a fragment thereof, the other one is for any other antigen, and preferably for a cell-surface protein or receptor or receptor subunit, preferably one that is tumor specific. Alternatively, tetramer-type technology may create multivalent reagents. In a prefened embodiment, the antibodies to ovarian cancer protein are capable of reducing or eliminating a biological function of an ovarian cancer protein, as is described below. That is, the addition of anti-ovarian cancer protein antibodies (either polyclonal or preferably monoclonal) to ovarian cancer tissue (or cells containing ovarian cancer) may reduce or eliminate the ovarian cancer. Generally, at least a 25% decrease in activity, growth, size or the like is prefened, with at least about 50% being particularly prefened and about a 95-100% decrease being especially prefened.

In a prefened embodiment the antibodies to the ovarian cancer proteins are humanized antibodies (e.g., Xenerex Biosciences; Medarex, Inc.; Abgenix, Inc.; Protein Design Labs, Inc.) Humanized forms of non-human (e.g., murine) antibodies are chimeric molecules of immunoglobulins, immunoglobulin chains or fragments thereof (such as Fv, Fab, Fab', F(ab')2 or other antigen-binding subsequences of antibodies) which contain minimal sequence derived from non-human immunoglobulin. Humanized antibodies include human immunoglobulins (recipient antibody) in which residues from a complementary determining region (CDR) ofthe recipient are replaced by residues from a CDR of a non- human species (donor antibody) such as mouse, rat or rabbit having the desired specificity, affinity and capacity. In some instances, Fv framework residues ofthe human immunoglobulin are replaced by conesponding non-human residues. Humanized antibodies may also comprise residues which are found neither in the recipient antibody nor in the imported CDR or framework sequences. In general, a humanized antibody will comprise substantially all of at least one, and typically two, variable domains, in which all or substantially all ofthe CDR regions conespond to those of a non-human immunoglobulin and all or substantially all ofthe framework (FR) regions are those of a human immunoglobulin consensus sequence. The humanized antibody optimally also will comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin. Humanization can be essentially performed following the method of Winter and co-workers, e.g., by substituting rodent CDRs or CDR sequences for the conesponding sequences of a human antibody. See, e.g., Jones, et al. (1986) Nature 321 :522- 525; Riechmann, et al. (1988) Nature 332:323-329; Presta (1992) Cun. Op. Struct.^' Biol. 2:593-596; and Verhoeyen, et al. (1988) Science 239:1534-1536). Accordingly, such humanized antibodies are chimeric antibodies (U.S. Patent No. 4,816,567), wherein substantially less than an intact human variable domain has been substituted by the conesponding sequence from a non-human species.

Human antibodies can also be produced using various techniques known in the art, including phage display libraries (see, e.g., Hoogenboom and Winter (1991) J. Mol. Biol. 227:381-388; and Marks, et al. (1991) J. Mol. Biol. 222:581-597) or human monoclonal antibodies (see, e.g., p. 77, Cole, et al. in Reisfeld and Sell (1985) Monoclonal Antibodies and Cancer Therapy Liss; and Boerner, et al. (1991) J. Immunol. 147:86-95). Similarly, human antibodies can be made by introducing of human immunoglobulin loci into transgenic animals, e.g., mice in which the endogenous immunoglobulin genes have been partially or completely inactivated. Upon challenge, human antibody production is observed, which closely resembles that seen in humans in all respects, including gene reanangement, assembly, and antibody repertoire. See, e.g., U.S. Patent Nos. 5,545,807; 5,545,806; 5,569,825; 5,625,126; 5,633,425; 5,661,016; Marks, et al. (1992) Bio/Technology 10:779- 783; Lonberg, et al. (1994) Nature 368:856-859; Morrison (1994) Nature 368:812-13; Neuberger (1996) Nature Biotechnology 14:826 commenting on Fishwild, et al. (1996) Nature Biotechnology 14:845-51 ; and Lonberg and Huszar (1995) Intern. Rev. Immunol. 13:65-93.

By immunotherapy is meant treatment of ovarian cancer, e.g., with an antibody raised against ovarian cancer proteins. As used herein, immunotherapy can be passive or active. Passive immunotherapy as defined herein is the passive transfer of antibody to a recipient (patient). Active immunization is the induction of antibody and/or T-cell responses in a recipient (patient). Induction of an immune response is the result of providing the recipient with an antigen to which antibodies are raised. The antigen may be provided by injecting a polypeptide against which antibodies are desired to be raised into a recipient, or contacting the recipient with a nucleic acid capable of expressing the antigen and under conditions for expression ofthe antigen, leading to an immune response.

In a prefened embodiment the ovarian cancer proteins against which antibodies are raised are secreted proteins as described above. Without being bound by theory, antibodies used for treatment, bind and prevent the secreted protein from binding to its receptor, thereby inactivating the secreted ovarian cancer protein.

In another prefened embodiment, the ovarian cancer protein to which antibodies are raised is a transmembrane protein. Without being bound by theory, antibodies used for treatment, bind the extracellular domain ofthe ovarian cancer protein and prevent it from binding to other proteins, such as circulating ligands or cell-associated molecules. The antibody may cause down-regulation ofthe transmembrane ovarian cancer protein. As will be appreciated by one of ordinary skill in the art, the antibody may be a competitive, non- competitive or uncompetitive inhibitor of protein binding to the extracellular domain ofthe ovarian cancer protein. The antibody is also an antagonist ofthe ovarian cancer protein. Further, the antibody prevents_, activation of the transmembrane ovarian cancer protein. In one aspect, when the antibody prevents the binding of other molecules to the ovarian cancer protein, the antibody prevents growth ofthe cell. The antibody may also be used to target or sensitize the cell to cytotoxic agents, including, but not limited to TNF-α, TNF-β, IL-1, INF- γ, and IL-2, or chemotherapeutic agents including 5FU, vinblastine, actinomycin D, cisplatin, methotrexate, and the like. In some instances the antibody belongs to a sub-type that activates serum complement when complexed with the transmembrane protein thereby mediating cytotoxicity or antigen-dependent cytotoxicity (ADCC). Thus, ovarian cancer is treated by administering to a patient antibodies directed against the transmembrane ovarian cancer protein. Antibody-labeling may activate a co-toxin, localize a toxin payload, or otherwise provide means to locally ablate cells.

In another prefened embodiment, the antibody is conjugated to an effector moiety. The effector moiety can be any number of molecules, including labeling moieties such as radioactive labels or fluorescent labels, or can be a therapeutic moiety. In one aspect the therapeutic moiety is a small molecule that modulates the activity ofthe ovarian cancer protein. In another aspect the therapeutic moiety modulates the activity of molecules associated with or in close proximity to the ovarian cancer protein. The therapeutic moiety may inhibit enzymatic activity such as protease or collagenase or protein kinase activity associated with ovarian cancer.

In a prefened embodiment, the therapeutic moiety can also be a cytotoxic agent. In this method, targeting the cytotoxic agent to ovarian cancer tissue or cells, results in a reduction in the number of afflicted cells, thereby reducing symptoms associated with ovarian cancer. Cytotoxic agents are numerous and varied and include, but are not limited to, cytotoxic drugs or toxins or active fragments of such toxins. Suitable toxins and their conesponding fragments include diphtheria A chain, exotoxin A chain, ricin A chain, abrin A chain, curcin, crotin, phenomycin, enomycin and the like. Cytotoxic agents also include radiochemicals made by conjugating radioisotopes to antibodies raised against ovarian cancer proteins, or binding of a radionuclide to a chelating agent that has been covalently attached to the antibody. Targeting the therapeutic moiety to transmembrane ovarian cancer proteins not only serves to increase the local concentration of therapeutic moiety in the ovarian cancer afflicted area, but also serves to reduce deleterious side effects that may be associated with the untargeted therapeutic moiety. In another prefened embodiment, the ovarian cancer protein against which the antibodies are raised is an intracellular protein. In this case, the antibody may be conjugated to a protein which facilitates entry into the cell. In one case, the antibody enters the cell by endocytosis. In another embodiment, a nucleic acid encoding the antibody is administered to the individual or cell. Moreover, wherein the ovarian cancer protein can be targeted within a cell, e.g., the nucleus, an antibody thereto contains a signal for that target localization, e.g., a nuclear localization signal.

The ovarian cancer antibodies ofthe invention specifically bind to ovarian cancer proteins. By "specifically bind" herein is meant that the antibodies bind to the protein with a K of at least about 0.1 mM, more usually at least about 1 μM, preferably at least about 0.1 μM or better, and most preferably, 0.01 μM or better. Selectivity of binding is also important.

Detection of ovarian cancer sequence for diagnostic and therapeutic applications

In one aspect, the RNA expression levels of genes are determined for different cellular states in the ovarian cancer phenotype. Expression levels of genes in normal tissue (e.g., not undergoing ovarian cancer) and in ovarian cancer tissue (and in some cases, for varying severities of ovarian cancer that relate to prognosis, as outlined below, or in non- malignant disease are evaluated to provide expression profiles. An expression profile of a particular cell state or point of development is essentially a "fingerprint" ofthe state ofthe cell. While two states may have any particular gene similarly expressed, the evaluation of a number of genes simultaneously allows the generation of a gene expression profile that is reflective ofthe state ofthe cell. By comparing expression profiles of cells in different states, information regarding which genes are important (including both up- and down-regulation of genes) in each of these states is obtained. Then, diagnosis may be performed or confirmed to determine whether a tissue sample has the gene expression profile of normal or cancerous tissue. This will provide for molecular diagnosis of related conditions. "Differential expression," or grammatical equivalents as used herein, refers to qualitative or quantitative differences in the temporal and/or cellular gene expression patterns within and among cells and tissue. Thus, a differentially expressed gene can qualitatively have its expression altered, including an activation or inactivation, in, e.g., normal versus ovarian cancer tissue. Genes may be turned on or turned off in a particular state, relative to another state thus permitting comparison of two or more states. A qualitatively regulated gene will exhibit an expression pattern within a state or cell type which is detectable by standard techniques. Some genes will be expressed in one state or cell type, but not in both. Alternatively, the difference in expression may be quantitative, e.g., in that expression is modulated, either up-regulated, resulting in an increased amount of transcript, or down-regulated, resulting in a decreased amount of transcript. The degree to wliich expression differs need only be large enough to quantify via standard characterization techniques as outlined below, such as by use of Affymetrix GeneChip™ expression anays. See, e.g., Lockhart (1996) Nature Biotechnology 14:1675-1680. Other techniques include, but are not limited to, quantitative reverse transcriptase PCR, northern analysis, and RNase protection. As outlined above, preferably the change in expression (e.g., up-regulation or down-regulation) is at least about 50%, more preferably at least about 100%, more preferably at least about 150%, more preferably at least about 200%, with from 300 to at least 1000% being especially prefened.

Evaluation may be at the gene transcript, or the protein level. The amount of gene expression may be monitored using nucleic acid probes to the DNA or RNA equivalent ofthe gene transcript, and the quantification of gene expression levels, or, alternatively, the final gene product itself (protein) can be monitored, e.g., with antibodies to the ovarian cancer protein and standard immunoassays (ELISAs, etc.) or other techniques, including mass spectroscopy assays, 2D gel electrophoresis assays, etc. Proteins conesponding to ovarian cancer genes, e.g., those identified as being important in an ovarian cancer or disease phenotype, can be evaluated in an ovarian disease diagnostic test. In a prefened embodiment, gene expression monitoring is performed simultaneously on a number of genes.

Multiple protein expression monitoring can be performed, or on an individual basis. In this embodiment, the ovarian cancer nucleic acid probes are attached to biochips as outlined herein for the detection and quantification of ovarian cancer sequences in ^"a particular sample. The assays are further described below in the example. PCR techniques can be used to provide greater sensitivity. In a prefened embodiment nucleic acids encoding the ovarian cancer protein are detected. Although DNA or RNA encoding the ovarian cancer protein may be detected, of particular interest are methods wherein an mRNA encoding an ovarian cancer protein is detected. Probes to detect mRNA can be a nucleotide/deoxynucleotide probe that is complementary to and hybridizes with the mRNA and includes, but is not limited to, oligonucleotides, cDNA or RNA. Probes also should contain a detectable label, as defined herein. In one method the mRNA is detected after immobilizing the nucleic acid to be examined on a solid support such as nylon membranes and hybridizing the probe with the sample. Following washing to remove the non-specifically bound probe, the label is detected. In another method detection ofthe mRNA is performed in situ. In this method permeabilized cells or tissue samples are contacted with a detectably labeled nucleic acid probe for sufficient time to allow the probe to hybridize with the target mRNA. Following washing to remove the non-specifically bound probe, the label is detected. For example a digoxygenin labeled riboprobe (RNA probe) that is complementary to the mRNA encoding an ovarian cancer protein is detected by binding the digoxygenin with an anti-digoxygenin secondary antibody and developed with nitro blue tetrazolium and 5-bromo-4-chloro-3- indoyl phosphate.

In a prefened embodiment, various proteins from the three classes of proteins as described herein (secreted, transmembrane or intracellular proteins) are used in diagnostic assays. The ovarian cancer proteins, antibodies, nucleic acids, modified proteins and cells containing ovarian cancer sequences are used in diagnostic assays. This can be performed on an individual gene or conesponding polypeptide level. In a prefened embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes and/or conesponding polypeptides. As described and defined herein, ovarian cancer proteins, including intracellular, transmembrane, or secreted proteins, find use as prognostic or diagnostic markers of ovarian disease. Detection of these proteins in putative ovarian cancer tissue allows for detection, diagnosis, or prognosis of ovarian disease, and for selection of therapeutic strategy. In one embodiment, antibodies are used to detect ovarian cancer proteins. A prefened method separates proteins from a sample by electrophoresis on a gel (typically a denaturing and reducing protein gel, but may be another type of gel, including isoelectric focusing gels and the like). Following separation of proteins, the ovarian cancer protein is detected, e.g., by immunoblotting with antibodies raised against the ovarian cancer protein. Methods of immunoblotting are well known to those of ordinary skill in the art.

In another prefened method, antibodies to the ovarian cancer protein find use in in situ imaging techniques, e.g., in histology. See, e.g., Asai (ed. 1993) Methods in Cell Biology: Antibodies in Cell Biology (vol. 37) Academic Press. Cells are contacted with from one to many antibodies to the ovarian cancer protein(s). Following washing to remove nonspecific antibody binding, the presence ofthe antibody or antibodies is detected. In one embodiment the antibody is detected by incubating with a secondary antibody that contains a detectable label. In another method the primary antibody to the ovarian cancer protein(s) contains a detectable label, e.g., an enzyme marker that can act on a substrate. In another prefened embodiment each one of multiple primary antibodies contains a distinct and detectable label. This method finds particular use in simultaneous screening for a plurality of ovarian cancer proteins. As will be appreciated by one of ordinary skill in the art, many other histological imaging techniques are also provided by the invention.

In a prefened embodiment the label is detected in a fluorometer which has the ability to detect and distinguish emissions of different wavelengths. In addition, a fluorescence activated cell sorter (FACS) can be used in the method.

In another prefened embodiment, antibodies find use in diagnosing ovarian cancer from blood, serum, plasma, stool, and other samples. Such samples, therefore, are useful as samples to be probed or tested for the presence of ovarian cancer proteins. Antibodies can be used to detect an ovarian cancer protein by previously described immunoassay techniques including ELISA, immunoblotting (western blotting), immunoprecipitation, BIACORE technology, and the like. Conversely, the presence of antibodies may indicate an immune response against an endogenous ovarian cancer protein.

In a prefened embodiment, in situ hybridization of labeled ovarian cancer nucleic acid probes to tissue anays is done. For example, anays of tissue samples, including ovarian cancer tissue and/or normal tissue, are made. In situ hybridization (see, e.g., Ausubel, supra) is then performed. When comparing the fingerprints between an individual and a standard, the skilled artisan can make a diagnosis, a prognosis, or a prediction based on the findings. It is further understood that the genes which indicate the diagnosis may differ from those which indicate the prognosis and molecular profiling ofthe condition ofthe cells may lead to distinctions between responsive or refractory conditions or maybe predictive of outcomes. In a prefened embodiment, the ovarian cancer proteins, antibodies, nucleic acids, modified proteins and cells containing ovarian cancer sequences are used in prognosis assays. As above, gene expression profiles can be generated that conelate to ovarian cancer, clinical, pathological, or other information, in terms of long term prognosis. Again, this may be done on either a protein or gene level, with the use of a plurality of genes being prefened. As above, ovarian cancer probes may be attached to biochips for the detection and quantification of ovarian cancer sequences in a tissue or patient. The assays proceed as outlined above for diagnosis. PCR method may provide more sensitive and accurate quantification.

Assays for therapeutic compounds

In a prefened embodiment members ofthe proteins, nucleic acids, and antibodies as described herein are used in drug screening assays. The ovarian cancer proteins, antibodies, nucleic acids, modified proteins and cells containing ovarian cancer sequences are used in drug screening assays or by evaluating the effect of drug candidates on a "gene expression profile" or expression profile of polypeptides. In a prefened embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes after treatment with a candidate agent. See, e.g., Zlokamik, et al. (1998) Science 279:84-88; and Heid (1996) Genome Res. 6:986-994.

In a prefened embodiment, the ovarian cancer proteins, antibodies, nucleic acids, modified proteins and cells containing the native or modified ovarian cancer proteins are used in screening assays. That is, the present invention provides novel methods for screening for compositions which modulate the ovarian cancer phenotype or an identified physiological function of an ovarian cancer protein. As above, this can be done on an individual gene level or by evaluating the effect of drug candidates on a "gene expression profile". In a prefened embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes after treatment with a candidate agent. See, e.g., Zlokarnik, supra.

Having identified the differentially expressed genes herein, a variety of assays may be executed. In a prefened embodiment, assays may be run on an individual gene or protein level. That is, having identified a particular gene as up regulated in ovarian cancer, test compounds can be screened for the ability to modulate gene expression or for binding to the ovarian cancer protein. "Modulation" thus includes both an increase and a decrease in gene expression. The prefened amount of modulation will depend on the original change ofthe gene expression in normal versus tissue undergoing ovarian cancer, with changes of at least 10%, preferably 50%, more preferably 100-300%, and in some embodiments 300-1000% or greater. Thus, if a gene exhibits a 4-fold increase in ovarian cancer tissue compared to normal tissue, a decrease of about four-fold is often desired; similarly, a 10-fbld decrease in ovarian cancer tissue compared to normal tissue often provides a target value of a 10-fold increase in expression to be induced by the test compound. The amount of gene expression may be monitored using nucleic acid probes and the quantification of gene expression levels, or, alternatively, the gene product itself can be monitored, e.g., through the use of antibodies to the ovarian cancer protein and standard immunoassays. Proteomics and separation techniques may also allow quantification of expression. In a prefened embodiment, gene expression or protein monitoring of a number of entities, e.g., an expression profile, is monitored simultaneously. Such profiles will typically involve a plurality of those entities described herein.

In this embodiment, the ovarian cancer nucleic acid probes are attached to biochips as outlined herein for the detection and quantification of ovarian cancer sequences in a particular cell. Alternatively, PCR may be used. Thus, a series, e.g., of microtiter plate, may be used with dispensed primers in desired wells. A PCR reaction can then be performed and analyzed for each well.

Expression monitoring can be performed to identify compounds that modify the expression of one or more ovarian cancer-associated sequences, e.g., a polynucleotide sequence set out inTables 1-26. Generally, in a prefened embodiment, a test modulator is added to the cells prior to analysis. Moreover, screens are also provided to identify agents that modulate ovarian cancer, modulate ovarian cancer proteins, bind to an ovarian cancer protein, or interfere with the binding of an ovarian cancer protein and an antibody or other binding partner. The term "test compound" or "drug candidate" or "modulator" or grammatical equivalents as used herein describes any molecule, e.g., protein, oligopeptide, small organic molecule, polysaccharide, polynucleotide, etc., to be tested for the capacity to directly or indirectly alter the ovarian cancer phenotype or the expression of an ovarian cancer sequence, e.g., a nucleic acid or protein sequence. In prefened embodiments, modulators alter expression profiles, or expression profile nucleic acids or proteins provided herein^" In one embodiment, the modulator suppresses an ovarian cancer phenotype, e.g., to a normal or non- malignant tissue fingerprint. In another embodiment, a modulator induced an ovarian cancer phenotype. Generally, a plurality of assay mixtures are run in parallel with different agent concentrations to obtain a differential response to the various concentrations. Typically, one of these concentrations serves as a negative control, e.g., at zero concentration or below the level of detection.

Drug candidates encompass numerous chemical classes, though typically they are organic molecules, preferably small organic compounds having a molecular weight of more than 100 and less than about 2,500 daltons. Prefened small molecules are less than 2000, or less than 1500 or less than 1000 or less than 500 D. Candidate agents comprise functional groups necessary for structural interaction with proteins, particularly hydrogen bonding, and typically include at least an amine, carbonyl, hydroxyl or carboxyl group, preferably at least two ofthe functional chemical groups. The candidate agents often comprise cyclical carbon or heterocyclic structures and/or aromatic or polyaromatic structures substituted with one or more ofthe above functional groups. Candidate agents are also found among biomolecules including peptides, saccharides, fatty acids, steroids, purines, pyrimidines, derivatives, structural analogs or combinations thereof. Particularly prefened are peptides. In one aspect, a modulator will neutralize the effect of an ovarian cancer protein. By

"neutralize" is meant that activity of a protein is inhibited or blocked and the consequent effect on the cell.

In certain embodiments, combinatorial libraries of potential modulators will be screened for an ability to bind to an ovarian cancer polypeptide or to modulate activity. Conventionally, new chemical entities with useful properties are generated by identifying a chemical compound (called a "lead compound") with some desirable property or activity, e.g., inhibiting activity, creating variants ofthe lead compound, and evaluating the property and activity of those variant compounds. Often, high throughput screening (HTS) methods are employed for such an analysis. In one prefened embodiment, high throughput screening methods involve providing a library containing a large number of potential therapeutic compounds (candidate compounds). Such "combinatorial chemical libraries" are then screened in one or more assays to identify those library members (particular chemical species or subclasses) that display a desired characteristic activity. The compounds thus identified can serve as conventional "lead compounds" or can themselves be used as potential or actual therapeutics.

A combinatorial chemical library is a collection of diverse chemical compounds generated by either chemical synthesis or biological synthesis by combining a number of chemical "building blocks" such as reagents. For example, a linear combinatorial chemical library, such as a polypeptide (e.g., mutein) library, is formed by combining a set of chemical building blocks called amino acids in every possible way for a given compound length (e.g., the number of amino acids in a polypeptide compound). Millions of chemical compounds can be synthesized through such combinatorial mixing of chemical building blocks. See, e.g., Gallop, et al. (1994) J. Med. Chem. 37:1233-1251^°.

Preparation and screening of combinatorial chemical libraries is well known to those of skill in the art. Such combinatorial chemical libraries include, but are not limited to, peptide libraries (see, e.g., U.S. Patent No. 5,010,175; Furka (1991) Pent. Prot. Res. 37:487- 493; and Houghton, et al. (1991) Nature 354:84-88), peptoids (PCT Publication No WO 91/19735), encoded peptides (PCT Publication WO 93/20242), random bio-oligomers (PCT Publication WO 92/00091), benzodiazepines (U.S. Pat. No. 5,288,514), diversomers such as hydantoins, benzodiazepines and dipeptides (Hobbs, et al. (1993) Proc. Nat'l Acad. Sci. USA 90:6909-913), vinylogous polypeptides (Hagihara, et al. (1992) J. Amer. Chem. Soc. 114:6568-570), non-peptidal peptidomimetics with a Beta-D-Glucose scaffolding (Hirschmann, et al. (1992) J. Amer. Chem. Soc. 114:9217-218), analogous organic syntheses of small compound libraries (Chen, et al. (1994) J. Amer. Chem. Soc. 116:2661-662), oligocarbamates (Cho, et al. (1993) Science 261:1303-305), and/or peptidyl phosphonates (Campbell, et al.(1994) J. Org. Chem. 59:658-xxx). See, generally, Gordon, et al. (1994) J. Med. Chem. 37:1385-401, nucleic acid libraries (see, e.g., Stratagene, Corp.), peptide nucleic acid libraries (see, e.g., U.S. Patent 5,539,083), antibody libraries (see, e.g., Vaughn, et al.(1996) Nature Biotechnology 14:309-314; and PCT US96/10287), carbohydrate libraries (see, e.g., Liang, et al. (1996) Science 274:1520-1522; and U.S. Patent No. 5,593,853), and small organic molecule libraries (see, e.g., benzodiazepines, page 33, Baum (Jan. 18, 1993) C&E News: isoprenoids, U.S. Patent No. 5,569,588; thiazolidinones and metathiazanones, U.S. Patent No. 5,549,974; pynolidines, U.S. Patent Nos. 5,525,735 and 5,519,134; morpholino compounds, U.S. Patent No. 5,506,337; benzodiazepines, U.S. Patent No.

5,288,514; and the like).

Devices for the preparation of combinatorial libraries are commercially available. See, e.g., 357 MPS, 390 MPS, Advanced Chem Tech, Louisville KY; Symphony, Rainin, Woburn, MA; 433A Applied Biosystems, Foster City, CA; 9050 Plus, Millipore, Bedford, MA.

A number of well known robotic systems have also been developed for solution phase chemistries. These systems include automated workstations like the automated synthesis apparatus developed by Takeda Chemical Industries, LTD. (Osaka, Japan) and many robotic systems utilizing robotic arms (Zymate II, Zymark Corporation, Hopkinton, MA; Orca, Hewlett-Packard, Palo Alto, CA), which mimic the manual synthetic operations performed by a chemist. Any ofthe above devices are suitable for use with the present invention. The nature and implementation of modifications to these devices (if any) so that they can operate as discussed herein will be apparent to persons skilled in the relevant art. In addition, numerous combinatorial libraries are themselves commercially available (see, e.g., ComGenex, Princeton, N.J.; Asinex, Moscow, RU; Tripos, Inc., St. Louis, MO; ChemStar, Ltd, Moscow, RU; 3D Pharmaceuticals, Exton, PA; Martek Biosciences, Columbia, MD; etc.).

The assays to identify modulators are amenable to high throughput screening. Prefened assays thus detect enhancement or inhibition of ovarian cancer gene transcription, inhibition or enhancement of polypeptide expression, and inhibition or enhancement of polypeptide activity. High throughput assays for the presence, absence, quantification, or other properties of particular nucleic acids or protein products are well known to those of skill in the art. Similarly, binding assays and reporter gene assays are similarly well known. Thus, e.g., U.S. Patent No. 5,559,410 discloses high throughput screening methods for proteins, U.S. Patent No. 5,585,639 discloses high throughput screening methods for nucleic acid binding (e.g., in anays), while U.S. Patent Nos. 5,576,220 and 5,541,061 disclose high throughput methods of screening for ligand/antibody binding.

In addition, high throughput screening systems are commercially available (see, e.g., Zymark Corp., Hopkinton, MA; Air Technical Industries, Mentor, OH; Beckman Instruments, Inc. Fullerton, CA; Precision Systems, Inc., Natick, MA, etc.). These systems typically automate entire procedures, including all sample and reagent pipetting, liquid dispensing, timed incubations, and final readings ofthe microplate in detector(s) appropriate for the assay. These configurable systems provide high throughput and rapid start up as well as a high degree of flexibility and customization. The manufacturers of such systems provide detailed protocols for various high throughput systems. Thus, e.g., Zymark Corp. provides technical bulletins describing screening systems for detecting the modulation of gene transcription, ligand binding, and the like.

In one embodiment, modulators are proteins, often naturally occurring proteins or fragments of naturally occurring proteins. Thus, e.g., cellular extracts containing proteins, or random or directed digests of proteinaceous cellular extracts, may be used. In this way libraries of proteins may be made for screening in the methods ofthe invention. Particularly prefened in this embodiment are libraries of bacterial, fungal, viral, and mammalian proteins, with the latter being prefened, and human proteins being especially prefened. Particularly useful test compound will be directed to the class of proteins to which the target belongs, e.g., substrates for enzymes or ligands and receptors.

In a prefened embodiment, modulators are peptides of from about 5 to about 30 amino acids, with from about 5 to about 20 amino acids being prefened, and from about 7 to about 15 being particularly prefened. The peptides may be digests of naturally occurring proteins as is outlined above, random peptides, or "biased" random peptides. By

"randomized" or grammatical equivalents herein is meant that each nucleic acid and peptide consists of essentially random nucleotides and amino acids, respectively. Since generally these random peptides (or nucleic acids, discussed below) are chemically synthesized, they may incorporate any nucleotide or amino acid at any position. The synthetic process can be designed to generate randomized proteins or nucleic acids, to allow the formation of all or most ofthe possible combinations over the length ofthe sequence, thus forming a library of randomized candidate bioactive proteinaceous agents.

In one embodiment, the library is fully randomized, with no sequence preferences or constants at any position. In a prefened embodiment, the library is biased. That is, some positions within the sequence are either held constant, or are selected from a limited number of possibilities. For example, in a prefened embodiment, the nucleotides or amino acid residues are randomized within a defined class, e.g., of hydrophobic amino acids, hydrophilic residues, sterically biased (either small or large) residues, towards the creation of nucleic acid binding domains, the creation of cysteines, for cross-linking, prolines for SH-3 domains, serines, threonines, tyrosines or histidines for phosphorylation sites, etc., or to purines, etc.

Modulators of ovarian cancer can also be nucleic acids, as defined above.

As described above generally for proteins, nucleic acid modulating agents may be naturally occurring nucleic acids, random nucleic acids, or "biased" random nucleic acids. For example, digests of procaryotic or eucaryotic genomes maybe used as is outlined above for proteins.

In a prefened embodiment, the candidate compounds are organic chemical moieties, a wide variety of which are available in the literature. After the candidate agent has been added and the cells allowed to incubate for some period oftime, the sample containing a target sequence to be analyzed is added to the biochip. If required, the target sequence is prepared using known techniques. For example, the sample may be treated to lyse the cells, using known lysis buffers, electroporation, etc., with purification and/or amplification such as PCR performed as appropriate. For example, an in vitro transcription with labels covalently attached to the nucleotides is performed. Generally, the nucleic acids are labeled with biotin-FITC or PE, or with cy3 or cy5.

In a prefened embodiment, the target sequence is labeled with, e.g., a fluorescent, a chemiluminescent, a chemical, or a radioactive signal, to provide a means of detecting the target sequence's specific binding to a probe. The label also can be an enzyme, such as, alkaline phosphatase or horseradish peroxidase, which when provided with an appropriate substrate produces a product that can be detected. Alternatively, the label can be a labeled compound or small molecule, such as an enzyme inhibitor, that binds but is not catalyzed or altered by the enzyme. The label also can be a moiety or compound, such as, an epitope tag or biotin which specifically binds to streptavidin. For the example of biotin, the streptavidin is labeled as described above, thereby, providing a detectable signal for the bound target sequence. Unbound labeled streptavidin is typically removed prior to analysis.

As will be appreciated by those in the art, these assays can be direct hybridization assays or can comprise "sandwich assays", which include the use of multiple probes, as is generally outlined in U.S. Patent Nos. 5,681,702; 5,597,909; 5,545,730; 5,594,117; 5,591,584; 5,571,670; 5,580,731; 5,571,670; 5,591,584; 5,624,802; 5,635,352; 5,594,118; 5,359,100; 5,124,246; and 5,681,697, each of which is hereby incorporated by reference. In this embodiment, in general, the target nucleic acid is prepared as outlined above, and then added to the biochip comprising a plurality of nucleic acid probes, under conditions that allow the formation of a hybridization complex. A variety of hybridization conditions may be used in the present invention, including high, moderate and low stringency conditions as outlined above. The assays are generally run under stringency conditions which allows formation ofthe label probe hybridization complex only in the presence of target. Stringency can be controlled by altering a step parameter that is a thermodynamic variable, including, but not limited to, temperature, formamide concentration, salt concentration, chaotropic salt concentration pH, organic solvent concentration, etc.

These parameters may also be used to control non-specific binding, as is generally outlined in U.S. Patent No. 5,681,697. Thus it may be desirable to perform certain steps at higher stringency conditions to reduce non-specific binding.

The reactions outlined herein may be accomplished in a variety of ways. Components ofthe reaction may be added simultaneously, or sequentially, in different orders, with prefened embodiments outlined below. In addition, the reaction may include a variety of other reagents. These include salts, buffers, neutral proteins, e.g., albumin, detergents, etc. which may be used to facilitate optimal hybridization and detection, and/or reduce nonspecific or background interactions. Reagents that otherwise improve the efficiency ofthe assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., may also be used as appropriate, depending on the sample preparation methods and purity ofthe target. The assay data are analyzed to determine the expression levels, and changes in expression levels as between states, of individual genes, forming a gene expression profile.

Screens are performed to identify modulators ofthe ovarian cancer phenotype. In one embodiment, screening is performed to identify modulators that can induce or suppress a particular expression profile, thus preferably generating the associated phenotype. In another embodiment, e.g., for diagnostic applications, having identified differentially expressed genes important in a particular state, screens can be performed to identify modulators that alter expression of individual genes. In an another embodiment, screening is performed to identify modulators that alter a biological function ofthe expression product of a differentially expressed gene. Again, having identified the importance of a gene in a particular state, screens are performed to identify agents that bind and/or modulate the biological activity of the gene product.

In addition screens can be done for genes that are induced in response to a candidate agent. After identifying a modulator based upon its ability to suppress an ovarian cancer expression pattern leading to a normal expression pattern, or to modulate a single ovarian cancer gene expression profile so as to mimic the expression ofthe gene from normal tissue, a screen as described above can be performed to identify genes that are specifically modulated in response to the agent. Comparing expression profiles between normal tissue and agent treated ovarian cancer tissue reveals genes that are not expressed in normal tissue or ovarian cancer tissue, but are expressed in agent treated tissue. These agent-specific sequences can be identified and used by methods described herein for ovarian cancer genes or proteins. In particular these sequences and the proteins they encode find use in marking or identifying agent treated cells. In addition, antibodies can be raised against the agent induced proteins and used to target novel therapeutics to the treated ovarian cancer tissue sample.

Thus, in one embodiment, a test compound is administered to a population of ovarian cancer cells, that have an associated ovarian cancer expression profile. By "administration" or "contacting" herein is meant that the candidate agent is added to the cells in such a manner as to allow the agent to act upon the cell, whether by uptake and intracellular action, or by action at the cell surface. In some embodiments, nucleic acid encoding a proteinaceous candidate agent (e.g., a peptide) may be put into a viral construct such as an adenoviral or retroviral construct, and added to the cell, such that expression ofthe peptide agent is accomplished, e.g., PCT US97/01019. Regulatable gene therapy systems can also be used. Once the test compound has been administered to the cells, the cells can be washed if desired and are allowed to incubate under preferably physiological conditions for some period oftime. The cells are then harvested and a new gene expression profile is generated, as outlined herein.

Thus, e.g., ovarian cancer or non-malignant tissue may be screened for agents that modulate, e.g., induce or suppress the ovarian cancer phenotype. A change in at least one gene, preferably many, ofthe expression profile indicates that the agent has an effect on ovarian cancer activity. By defining such a signature for the ovarian cancer phenotype, screens for new drugs that alter the phenotype can be devised. With this approach, the drug target need not be known and need not be represented in the original expression screening platform, nor does the level of transcript for the target protein need to change. In a prefened embodiment, as outlined above, screens may be done on individual genes and gene products (proteins). That is, having identified a particular differentially expressed gene as important in a particular state, screening of modulators of either the expression ofthe gene or the gene product itself can be done. The gene products of differentially expressed genes are sometimes refened to herein as "ovarian cancer proteins" or a "ovarian cancer modulatory protein". The ovarian cancer modulatory protein may be a fragment, or alternatively, be the full length protein to the fragment encoded by the nucleic acids ofthe Tables. Preferably, the ovarian cancer modulatory protein is a fragment. In a prefened embodiment, the ovarian cancer amino acid sequence which is used to determine sequence identity or similarity is encoded by a nucleic acid ofthe Tables. In another embodiment, the sequences are naturally occurring allelic variants of a protein encoded by a nucleic acid ofthe Tables. In another embodiment, the sequences are sequence variants as further described herein. Preferably, the ovarian cancer modulatory protein is a fragment of approximately 14 to 24 amino acids long. More preferably the fragment is a soluble fragment. Preferably, the fragment includes a non-transmembrane region. In a prefened embodiment, the fragment has an N-terminal Cys to aid in solubility. In another embodiment, the C-terminus ofthe fragment is kept as a free acid and the N-terminus is a free amine to aid in coupling, e.g., to cysteine. Or, the ovarian cancer proteins are conjugated to an immunogenic agent, e.g., to BSA.

Measurements of ovarian cancer polypeptide activity, or of ovarian cancer or the ovarian cancer phenotype can be performed using a variety of assays. For example, the effects ofthe test compounds upon the function ofthe ovarian cancer polypeptides can be measured by examining parameters described above. A suitable physiological change that affects activity can be used to assess the influence of a test compound on the polypeptides of this invention. When the functional consequences are determined using intact cells or animals, one can also measure a variety of effects such as, in the case of ovarian cancer associated with tumors, tumor growth, tumor metastasis, neovascularization, hormone release, transcriptional changes to both known and uncharacterized genetic markers (e.g., northern blots), changes in cell metabolism such as cell growth or pH changes, and changes in intracellular second messengers such as cGMP. In the assays ofthe invention, mammalian ovarian cancer polypeptide is typically used, e.g., mouse, preferably human.

Assays to identify compounds with modulating activity can be performed in vitro. For example, an ovarian cancer polypeptide is first contacted with a potential modulator and incubated for a suitable amount oftime, e.g., from 0.5 to 48 hours. In one embodiment, the ovarian cancer polypeptide levels are determined in vitro by measuring the level of protein or mRNA. The level of protein is measured using immunoassays such as western blotting, ELISA and the like with an antibody that selectively binds to the ovarian cancer polypeptide or a fragment thereof. For measurement of mRNA, amplification, e.g., using PCR, LCR, or hybridization assays, e.g., northern hybridization, RNAse protection, dot blotting, are prefened. The level of protein or mRNA is detected using directly or indirectly labeled detection agents, e.g., fluorescently or radioactively labeled nucleic acids, radioactively or enzymatically labeled antibodies, and the like, as described herein.

Alternatively, a reporter gene system can be devised using the ovarian cancer protein promoter operably linked to a reporter gene such as luciferase, green fluorescent protein, CAT, or β-gal. The reporter construct is typically transfected into a cell. After treatment with a potential modulator, the amount of reporter gene transcription, translation, or activity is measured according to standard techniques known to those of skill in the art.

In a prefened embodiment, as outlined above, screens may be done on individual genes and gene products (proteins). That is, having identified a particular differentially expressed gene as important in a particular state, screening of modulators ofthe expression of the gene or the gene product itself can be done. The gene products of differentially expressed genes are sometimes refened to herein as "ovarian cancer proteins." The ovarian cancer protein may be a fragment, or alternatively, be the full length protein to a fragment shown herein.

In one embodiment, screening for modulators of expression of specific genes is performed. Typically, the expression of only one or a few genes are evaluated. In another embodiment, screens are designed to first find compounds that bind to differentially expressed proteins. These compounds are then evaluated for the ability to modulate differentially expressed activity. Moreover, once initial candidate compounds are identified, variants can be further screened to better evaluate structure activity relationships. In a prefened embodiment, binding assays are done. In general, purified or isolated gene product is used; that is, the gene products of one or more differentially expressed nucleic acids are made. For example, antibodies are generated to the protein gene products, and standard immunoassays are run to determine the amount of protein present. Alternatively, cells comprising the ovarian cancer proteins can be used in the assays. Thus, in a prefened embodiment, the methods comprise combining an ovarian cancer protein and a candidate compound, and determining the binding ofthe compound to the ovarian cancer protein. Prefened embodiments utilize the human ovarian cancer protein, although other mammalian proteins, e.g., counterparts, may also be used, e.g., for the development of animal models of human disease. In some embodiments, as outlined herein, variant or derivative ovarian cancer proteins may be used.

Generally, in a prefened embodiment ofthe methods herein, the ovarian cancer protein or the candidate agent is non-diffusably bound to an insoluble support having isolated sample receiving areas (e.g., a microtiter plate, an anay, etc.). The insoluble supports may be made of any composition to which the compositions can be bound, is readily separated from soluble material, and is otherwise compatible with the overall method of screening^ The surface of such supports may be solid or porous and of any convenient shape. Examples of suitable insoluble supports include microtiter plates, anays, membranes and beads. These are typically made of glass, plastic (e.g., polystyrene), polysaccharides, nylon or nitrocellulose, teflon™, etc. Microtiter plates and arrays are especially convenient because a large number of assays can be carried out simultaneously, using small amounts of reagents and samples. The particular manner of binding ofthe composition is not crucial so long as it is compatible with the reagents and overall methods ofthe invention, maintains the activity ofthe composition and is non-diffusible. Prefened methods of binding include the use of antibodies (which do not sterically block either the ligand binding site or activation sequence when the protein is bound to the support), direct binding to "sticky" or ionic supports, chemical crosslinking, the synthesis ofthe protein or agent on the surface, etc. Following binding ofthe protein or agent, excess unbound material is removed by washing. The sample receiving areas may then be blocked through incubation with bovine serum albumin (BSA), casein or other innocuous protein or other moiety.

In a prefened embodiment, the ovarian cancer protein is bound to the support, and a test compound is added to the assay. Alternatively, the candidate agent is bound to the support and the ovarian cancer protein is added. Novel binding agents include specific antibodies, non-natural binding agents identified in screens of chemical libraries, peptide analogs, etc. Of particular interest are screening assays for agents that have a low toxicity for human cells. A wide variety of assays may be used for this purpose, including labeled in vitro protein-protein binding assays, electrophoretic mobility shift assays, immunoassays for protein binding, functional assays (phosphorylation assays, etc.) and the like. The determination ofthe binding ofthe test modulating compound to the ovarian cancer protein may be done in a number of ways. In a prefened embodiment, the compound is labeled, and binding determined directly, e.g., by attaching all or a portion ofthe ovarian cancer protein to a solid support, adding a labeled candidate agent (e.g., a fluorescent label), washing off excess reagent, and determining whether the label is present on the solid support. Various blocking and washing steps may be utilized as appropriate.

In some embodiments, only one ofthe components is labeled, e.g., the proteins (or proteinaceous candidate compounds) can be labeled. Alternatively, more than one component can be labeled with different labels, e.g., ^5j f_{or me} proteins and a fluorophor for the compound. Proximity reagents, e.g., quenching or energy transfer reagents are also useful.

In one embodiment, the binding ofthe test compound is determined by competitive binding assay. The competitor is a binding moiety known to bind to the target molecule (e.g., an ovarian cancer protein), such as an antibody, peptide, binding partner, ligand, etc. Under certain circumstances, there may be competitive binding between the compound and the binding moiety, with the binding moiety displacing the compound. In one embodiment, the test compound is labeled. Either the compound, or the competitor, or both, is added first to the protein for a time sufficient to allow binding, if present. Incubations may be performed at a temperature which facilitates optimal activity, typically 4-40° C. Incubation periods are typically optimized, e.g., to facilitate rapid high throughput screening. Typically between 0.1 and 1 hr will be sufficient. Excess reagent is generally removed or washed away. The second component is then added, and the presence or absence ofthe labeled component is followed, to indicate binding.

In a prefened embodiment, the competitor is added first, followed by the test compound. Displacement ofthe competitor is an indication that the test compound is binding to the ovarian cancer protein and thus is capable of binding to, and potentially modulating, the activity ofthe ovarian cancer protein. In this embodiment, either component can be labeled. Thus, e.g., if the competitor is labeled, the presence of label in the wash solution indicates displacement by the agent. Alternatively, if the test compound is labeled, the presence ofthe label on the support indicates displacement.

In an alternative embodiment, the test compound is added first, with incubation and washing, followed by the competitor. The absence of binding by the competitor may indicate that the test compound is bound to the ovarian cancer protein with a higher affinity. Thus, if the test compound is labeled, the presence ofthe label on the support, coupled with a lack of competitor binding, may indicate.that the test compound is capable of binding to the ovarian cancer protein.

In a prefened embodiment, the methods comprise differential screening to identity agents that are capable of modulating the activity ofthe ovarian cancer proteins. In this embodiment, the methods comprise combining an ovarian cancer protein and a competitor in a first sample. A second sample comprises a test compound, an ovarian cancer protein, and a competitor. The binding ofthe competitor is determined for both samples, and a change, or difference in binding between the two samples indicates the presence of an agent capable of binding to the ovarian cancer protein and potentially modulating its activity. That is, if the binding ofthe competitor is different in the second sample relative to the first sample, the agent is capable of binding to the ovarian cancer protein.

Alternatively, differential screening is used to identify drug candidates that bind to the native ovarian cancer protein, but cannot bind to modified ovarian cancer proteins. The structure ofthe ovarian cancer protein may be modeled, and used in rational drug design to synthesize agents that interact with that site. Drug candidates that affect the activity of an ovarian cancer protein are also identified by screening drugs for the ability to either enhance or reduce the activity ofthe protein.

Positive controls and negative controls may be used in the assays. Preferably control and test samples are performed in at least triplicate to obtain statistically significant results. Incubation of all samples is for a time sufficient for the binding ofthe agent to the protein. Following incubation, samples are washed free of non-specifically bound material and the amount of bound, generally labeled agent determined. For example, where a radiolabel is employed, the samples may be counted in a scintillation counter to determine the amount of bound compound.

A variety of other reagents may be included in the screening assays. These include reagents like salts, neutral proteins, e.g., albumin, detergents, etc. which may be used to facilitate optimal protein-protein binding and/or reduce non-specific or background interactions. Also reagents that otherwise improve the efficiency ofthe assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., may be used. The mixture of components may be added in an order that provides for the requisite binding. In a prefened embodiment, the invention provides methods for screening for a compound capable of modulating the activity of an ovarian cancer protein. The methods comprise adding a test compound, as defined above, to a cell comprising ovarian cancer proteins. Prefened cell types include almost any cell. The cells contain a recombinant nucleic acid that encodes an ovarian cancer protein. In a prefened embodiment, a library of candidate agents are tested on a plurality of cells.

In one aspect, the assays are evaluated in the presence or absence or previous or subsequent exposure of physiological signals, e.g., hormones, antibodies, peptides, antigens, cytokines, growth factors, action potentials, pharmacological agents including chemotherapeutics, radiation, carcinogenics, or other cells (e.g., cell-cell contacts). In another example, the determinations are determined at different stages ofthe cell cycle process.

In this way, compounds that modulate ovarian cancer agents are identified. Compounds with pharmacological activity are able to enhance or interfere with the activity of the ovarian cancer protein. Once identified, similar structures are evaluated to identify critical structural feature ofthe compound.

In one embodiment, a method of inhibiting ovarian cancer cell division is provided. The method comprises administration of an ovarian cancer inhibitor. In another embodiment, a method of inhibiting ovarian cancer is provided. The method comprises administration of an ovarian cancer inhibitor. In a further embodiment, methods of treating cells or individuals with ovarian cancer are provided. The method comprises administration of an ovarian cancer inhibitor.

In one embodiment, an ovarian cancer inhibitor is an antibody as discussed above. In another embodiment, the ovarian cancer inhibitor is an antisense or RNAi molecule.

A variety of cell viability, growth, proliferation, and metastasis assays are known to those of skill in the art, as described below.

Soft agar growth or colony formation in suspension Normal cells require a solid substrate to attach and grow. When the cells are transformed, they lose this phenotype and grow detached from the substrate. For example, transformed cells can grow in stined suspension culture or suspended in semi-solid media, such as semi-solid or soft agar. The transformed cells, when transfected with tumor suppressor genes, regenerate normal phenotype and require a solid substrate to attach and grow. Soft agar growth or colony formation in suspension assays can be used to identify modulators of ovarian cancer sequences, which when expressed in host cells, inhibit abnormal cellular proliferation and transformation. A therapeutic compound would reduce or eliminate the host cells' ability to grow in stined suspension culture or suspended in semi- solid media, such as semi-solid or soft. Techniques for soft agar growth or colony formation in suspension assays are described in Freshney (1994) Culture of Animal Cells: A Manual of Basic Technique (3d ed.) Wiley-Liss, herein incorporated by reference. See also, the methods section of Garkavtsev, et al. (1996), supra, herein incorporated by reference. Contact inhibition and density limitation of growth

Normal cells typically grow in a flat and organized pattern in a petri dish until they touch other cells. When the cells touch one another, they are contact inhibited and stop growing. When cells are transformed, however, the cells are not contact inhibited and continue to grow to high densities in disorganized foci. Thus, the transformed cells grow to a higher saturation density than normal cells. This can be detected morphologically by the formation of a disoriented monolayer of cells or rounded cells in foci within the regular pattern of normal sunounding cells. Alternatively, labeling index with (3H)-thymidine at saturation density can be used o measure density limitation of growth. See, e.g., Freshney (1994), supra. The transformed cells, when transfected with tumor suppressor genes, regenerate a normal phenotype and become contact inhibited and would grow to a lower density.

In this assay, labeling index with (3H)-thymidine at saturation density is a prefened method of measuring density limitation of growth. Transformed host cells are transfected with an ovarian cancer-associated sequence and are grown for 24 fir at saturation density in non-limiting medium conditions. The percentage of cells labeling with (3H)-thymidine is determined autoradiographically. See, e.g., Freslmey (1994), supra.

Growth factor or serum dependence

Transformed cells typically have a lower serum dependence than their normal counterparts. See, e.g., Temin (1966) J. Nat'l Cancer Inst. 37:167-175; Eagle, et al. (1970) J. Exp. Med. 131:836-879; and Freslmey, supra. This is in part due to release of various growth factors by the transformed cells. Growth factor or serum dependence of transformed host cells can be compared with that of control.

Tumor specific markers levels

Tumor cells release an increased amount of certain factors (hereinafter "tumor specific markers") than their normal counterparts. For example, plasminogen activator (PA) is released from human glioma at a higher level than from normal brain cells (see, e.g.,

Gullino, pp. 178-184 "Angiogenesis, tumor vascularization, and potential interference with tumor growth" in Mihich (ed. 1985) Biological Responses in Cancer Plenum. Similarly, tumor angiogenesis factor (TAF) is released at a higher level in tumor cells than their normal counterparts. See, e.g., Folkman (1992) Sem Cancer Biol. 3:89-96.

Various techniques which measure the release of these factors are described in Freshney (1994), supra. Also, see, Unkeless, et al. (1974) J. Biol. Chem. 249:4295-4305; Strickland and Beers (1976) J. Biol. Chem. 251:5694-5702; Whur, et al. (1980) Br. J. Cancer 42:305-312; Gullino, pp. 178-184 "Angiogenesis, tumor vascularization, and potential interference with tumor growth" in Mihich (ed. 1985) Biological Responses in Cancer Plenum; and Freshney (1985) Anticancer Res. 5:111-130.

Invasiveness into Matrigel

The degree of invasiveness into Matrigel or some other extracellular matrix constituent can be used as an assay to identify compounds that modulate ovarian cancer- associated sequences. Tumor cells exhibit a good conelation between malignancy and invasiveness of cells into Matrigel or some other extracellular matrix constituent. In this assay, tumorigenic cells are typically used as host cells. Expression of a tumor suppressor gene in these host cells would decrease invasiveness ofthe host cells.

Alternatively, the level of invasion of host cells can be measured by using filters coated with Matrigel or some other extracellular matrix constituent. Penetration into the gel, or through to the distal side ofthe filter, is rated as invasiveness, and rated histologically by number of cells and distance moved, or by pre-labeling the cells with 125j_ and counting the radioactivity on the distal side ofthe filter or bottom ofthe dish. See, e.g., Freshney (1984), supra.

Tumor growth in vivo Effects of ovarian cancer-associated sequences on cell growth can be tested in transgenic or immune-suppressed mice. Knock-out transgenic mice can be made, in which the ovarian cancer gene is disrupted or in which an ovarian cancer gene is inserted. Knockout transgenic mice can be made by insertion of a marker gene or other heterologous gene into the endogenous ovarian cancer gene site in the mouse genome via homologous recombination. Such mice can also be made by substituting the endogenous ovarian cancer gene with a mutated version ofthe ovarian cancer gene, or by mutating the endogenous ovarian cancer gene, e.g., by exposure to carcinogens. A DNA construct is introduced into the nuclei of embryonic stem cells. Cells containing the newly engineered genetic lesion are injected into a host mouse embryo, which is re-implanted into a recipient female. Some of these embryos develop into chimeric mice that possess germ cells partially derived from the mutant cell line. By breeding the chimeric mice it is possible to obtain a new line of mice containing the introduced genetic lesion. See, e.g., Capecchi, et al. (1989) Science 244:1288-1292. Chimeric targeted mice can be derived according to Hogan, et al. (1988) Manipulating the Mouse Embryo: A Laboratory Manual CSH Press; and Robertson (ed. 1987) Teratocarcinomas and Embryonic Stem Cells: A Practical Approach IRL Press, Washington, D.C. Alternatively, various immune-suppressed or immune-deficient host animals can be used. For example, genetically athymic "nude" mouse (see, e.g., Giovanella, et al. (1974) Nat'l Cancer Inst. 52:921-930), a SCID mouse, a thymectomized mouse, or an inadiated mouse (see, e.g., Bradley, et al. (1978) Br. J. Cancer 38:263-272; Selby, et al. (1980) Br. J.

Cancer 41 :52-61) can be used as a host. Transplantable tumor cells (typically about 10^ cells) injected into isogenic hosts will produce invasive tumors in a high proportions of cases, while normal cells of similar origin will not. In hosts which developed invasive tumors, cells expressing an ovarian cancer-associated sequences are injected subcutaneously. After a suitable length oftime, preferably 4-8 weeks, tumor growth is measured (e.g., by volume or by its two largest dimensions) and compared to the control. Tumors that have statistically significant reduction (using, e.g., Student's T test) are said to have inhibited growth.

Polynucleotide modulators of ovarian cancer

Antisense and RNAi Polynucleotides

In certain embodiments, the activity of an ovarian cancer-associated protein is down- regulated, or entirely inhibited, by the use of antisense polynucleotide, e.g., a nucleic acid complementary to, and which can preferably hybridize specifically to, a coding mRNA nucleic acid sequence, e.g., an ovarian cancer protein mRNA, or a subsequence thereof. Binding ofthe antisense polynucleotide to the mRNA reduces the translation and/or stability ofthe mRNA. In the context of this invention, antisense polynucleotides can comprise naturally- occurring nucleotides, or synthetic species formed from naturally-occurring subunits or their close homologs. Antisense polynucleotides may also have altered sugar moieties or inter- sugar linkages. Exemplary among these are the phosphorothioate and other sulfur containing species which are known for use in the art. Analogs are comprehended by this invention so long as they function effectively to hybridize with the ovarian cancer protein mRNA. See, e.g., Isis Pharmaceuticals, Carlsbad, CA; Sequitor, Inc., Natick, MA. Such antisense polynucleotides can readily be synthesized using recombinant means, or can be synthesized in vitro. Equipment for such synthesis is sold by several vendors, including Applied Biosystems. The preparation of other oligonucleotides such as phosphorothioates and alkylated derivatives is also well known to those of skill in the art. Antisense molecules as used herein include antisense or sense oligonucleotides. Sense oligonucleotides can, e.g., be employed to block transcription by binding to the anti- sense strand. The antisense and sense oligonucleotide comprise a single-stranded nucleic acid sequence (either RNA or DNA) capable of binding to target mRNA (sense) or DNA (antisense) sequences for ovarian cancer molecules. A prefened antisense molecule is for an ovarian cancer sequences in Tables 1-26, or for a ligand or activator thereof. Antisense or sense oligonucleotides, according to the present invention, comprise a fragment generally at least about 14 nucleotides, preferably from about 14 to 30 nucleotides. An antisense or a sense oligonucleotide can be developed based upon a cDNA sequence encoding a given protein. See, e.g., Stein and Cohen (1988) Cancer Res. 48:2659-2668; and van der Krol, et al. (1988) BioTechniques 6:958-976. RNA interference is a mechanism to suppress gene expression in a sequence specific manner. See, e.g., Brumelkamp, et al. (2002) Sciencexpress (21March2002); Sharp (1999) Genes Dev. 13:139-141; and Cathew (2001) Cun. Op. Cell Biol. 13:244-248. In mammalian cells, short, e.g., 21 nt, double stranded small interfering RNAs (siRNA) have been shown to be effective at inducing an RNAi response. See, e.g., Elbashir, et al. (2001) Nature 411 :494- 498. The mechanism may be used to down-regulate expression levels of identified genes, e.g., treatment of or validation of relevance to disease.

Ribozymes

In addition to antisense polynucleotides, ribozymes can be used to target and inhibit transcription of ovarian cancer-associated nucleotide sequences. A ribozyme is an RNA molecule that catalytically cleaves other RNA molecules. Different kinds of ribozymes have been described, including group I ribozymes, hammerhead ribozymes, hairpin ribozymes,

RNase P, and axhead ribozymes (see, e.g., Castanotto, et al. (1994) Adv. Pharmacol. 25: 289- 317 for a general review ofthe properties of different ribozymes).

The general features of hairpin ribozymes are described, e.g., in Hampel, et al. (1990) Nucl. Acids Res. 18:299-304; European Patent Publication No. 0 360 257; U.S. Patent No. 5,254,678. Methods of preparing them are well known to those of skill in the art. See, e.g., WO 94/26877; Ojwang, et al. (1993) Proc. Nat'l Acad. Sci. USA 90:6340-6344; Yamada, et al. (1994) Hum. Gene Ther. 1:39-45; Leavitt, et al. (1995) Proc. Nat'l Acad..Sci. USA 92:699-703; Leavitt, et al. (1994) Hum. Gene Ther. 5:1151-120; and Yamada, et al. (1994) Virology 205:121-126.

Polynucleotide modulators of ovarian cancer may be introduced into a cell containing the target nucleotide sequence by formation of a conjugate with a ligand binding molecule, as described in WO 91/04753. Suitable ligand binding molecules include, but are not limited to, cell surface receptors, growth factors, other cytokines, or other ligands that bind to cell surface receptors. Preferably, conjugation ofthe ligand binding molecule does not substantially interfere with the ability ofthe ligand binding molecule to bind to its conesponding molecule or receptor, or block entry ofthe sense or antisense oligonucleotide or its conjugated version into the cell. Alternatively, a polynucleotide modulator of ovarian cancer may be introduced into a cell containing the target nucleic acid sequence, e.g., by formation of an polynucleotide-lipid complex, as described in WO 90/10448. It is understood that the use of antisense molecules or knock out and knock in models may also be used in screening assays as discussed above, in addition to methods of treatment. Thus, in one embodiment, methods of modulating ovarian cancer in cells or organisms are provided. In one embodiment, the methods comprise administering to a cell an anti-ovarian cancer antibody that reduces or eliminates the biological activity of an endogenous ovarian cancer protein. Alternatively, the methods comprise administering to a cell or organism a recombinant nucleic acid encoding an ovarian cancer protein. This may be accomplished in any number of ways. In a prefened embodiment, e.g., when the ovarian cancer sequence is down-regulated in ovarian cancer, such state may be reversed by increasing the amount of ovarian cancer gene product in the cell. This can be accomplished, e.g., by over-expressing the endogenous ovarian cancer gene or administering a gene encoding the ovarian cancer sequence, using known gene-therapy techniques, e.g.. In a prefened embodiment, the gene therapy techniques include the incorporation ofthe exogenous gene using enhanced homologous recombination (EHR), e.g., as described in

PCT/US93/03868, hereby incorporated by reference in its entirety. Alternatively, e.g., when the ovarian cancer sequence is up-regulated in ovarian cancer, the activity ofthe endogenous ovarian cancer gene is decreased, e.g., by the administration of an ovarian cancer antisense or RNAi nucleic acid.

In one embodiment, the ovarian cancer proteins ofthe present invention may be used to generate polyclonal and monoclonal antibodies to ovarian cancer proteins. Similarly, the ovarian cancer proteins can be coupled, using standard technology, to affinity chromatography columns. These columns may then be used to purify ovarian cancer antibodies useful for production, diagnostic, or therapeutic purposes. In a prefened embodiment, the antibodies are generated to epitopes unique to an ovarian cancer protein; that is, the antibodies show little or no cross-reactivity to other proteins. The ovarian cancer antibodies may be coupled to standard affinity chromatography columns and used to purify ovarian cancer proteins. The antibodies may also be used as blocking polypeptides, as outlined above, since they will specifically bind to the ovarian cancer protein.

Methods of identifying variant ovarian cancer-associated sequences

Without being bound by theory, expression of various ovarian cancer sequences is conelated with ovarian cancer. Accordingly, disorders based on mutant or variant ovarian cancer genes may be determined. In one embodiment, the invention provides methods for identifying cells containing variant ovarian cancer genes, e.g., determining all or part ofthe sequence of at least one endogenous ovarian cancer genes in a cell. This may be accomplished using any number of sequencing techniques. In a prefened embodiment, the invention provides methods of identifying the ovarian cancer genotype of an individual, e.g., determining all or part ofthe sequence of at least one ovarian cancer gene ofthe individual. This is generally done in at least one tissue ofthe individual, and may include the evaluation of a number of tissues or different samples ofthe same tissue. The method may include comparing the sequence ofthe sequenced ovarian cancer gene to a known ovarian cancer gene, e.g., a wild-type gene.

The sequence of all or part ofthe ovarian cancer gene can then be compared to the sequence of a known ovarian cancer gene to determine if any differences exist. This can be done using any number of known homology programs, such as Bestfit, etc. hi a prefened embodiment, the presence of a difference in the sequence between the ovarian cancer gene of the patient and the known ovarian cancer gene conelates with a disease state or a propensity for a disease state, as outlined herein. In a prefened embodiment, the ovarian cancer genes are used as probes to determine the number of copies ofthe ovarian cancer gene in the genome.

In another prefened embodiment, the ovarian cancer genes are used as probes to determine the chromosomal localization ofthe ovarian cancer genes. Information such as chromosomal localization finds use in providing a diagnosis or prognosis in particular when chromosomal abnormalities such as translocations, and the like are identified in the ovarian cancer gene locus.

Administration of pharmaceutical and vaccine compositions In one embodiment, a therapeutically effective dose of an ovarian cancer protein or modulator thereof, is administered to a patient. By "therapeutically effective dose" herein is meant a dose that produces effects for which it is administered. The exact dose will depend on the purpose ofthe treatment, and will be ascertainable by one skilled in the art using known techniques. See, e.g., Ansel, et al. (1999) Pharmaceutical Dosage Forms and Drug Delivery Systems Lippincott; Lieberman (1992) Pharmaceutical Dosage Forms (vols. 1-3) Dekker, ISBN 0824770846, 082476918X, 0824712692, 0824716981; Lloyd (1999) The Art, Science and Technology of Pharmaceutical Compounding Amer. Pharmaceutical Assn.; and Pickar (1999) Dosage Calculations Thomson. Adjustments for ovarian cancer degradation, systemic versus localized delivery, and rate of new protease synthesis, as well as the age, body weight, general health, sex, diet, time of administration, drug interaction, and the severity ofthe condition may be necessary, and will be ascertainable with routine experimentation by those skilled in the art. U.S. Patent Application No. 09/687,576, further discloses the use of compositions and methods of diagnosis and treatment in ovarian cancer is hereby expressly incorporated by reference. A "patient" for the purposes ofthe present invention includes both humans and other animals, particularly mammals. Thus the methods are applicable to both human therapy and veterinary applications. In the prefened embodiment the patient is a mammal, preferably a primate, and in the most prefened embodiment the patient is human.

The administration ofthe ovarian cancer proteins and modulators thereof of the present invention can be done in a variety of ways as discussed above, including, but not limited to, orally, subcutaneously, intravenously, intra-nasally, transdermaliy, intraperitoneally, intramuscularly, intrapulmonary, vaginally, rectally, or intraocularly. In some instances, e.g., in the treatment of wounds and inflammation, the ovarian cancer proteins and modulators may be directly applied as a solution or spray.

The pharmaceutical compositions ofthe present invention comprise an ovarian cancer protein in a form suitable for administration to a patient. In the prefened embodiment, the pharmaceutical compositions are in a water soluble form, such as being present as pharmaceutically acceptable salts, which is meant to include both acid and base addition salts. "Pharmaceutically acceptable acid addition salt" refers to those salts that retain the biological effectiveness ofthe free bases and that are not biologically or otherwise undesirable, formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid and the like, and organic acids such as acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, and the like. "Pharmaceutically acceptable base addition salts" include those derived from inorganic bases such as sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts and the like. Particularly prefened are the ammonium, potassium, sodium, calcium, and magnesium salts. Salts derived from pharmaceutically acceptable organic non-toxic bases include salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine.

The pharmaceutical compositions may also include one or more ofthe following: carrier proteins such as serum albumin; buffers; fillers such as microcrystalline cellulose, lactose, corn and other starches; binding agents; sweeteners and other flavoring agents; coloring agents; and polyethylene glycol. The pharmaceutical compositions can be administered in a variety of unit dosage forms depending upon the method of administration. For example, unit dosage forms suitable for oral administration include, but are not limited to, powder, tablets, pills, capsules, and lozenges. It is recognized that ovarian cancer protein modulators (e.g., antibodies, antisense constructs, ribozymes, small organic molecules, etc.) when administered orally, should be protected from digestion. This is typically accomplished either by complexing the molecule(s) with a composition to render it resistant to acidic and enzymatic hydrolysis, or by packaging the molecule(s) in an appropriately resistant carrier, such as a liposome or a protection barrier. Means of protecting agents from digestion are well known in the art. The compositions for administration will commonly comprise an ovarian cancer protein modulator dissolved in a pharmaceutically acceptable carrier, preferably ah aqueous carrier. A variety of aqueous carriers can be used, e.g., buffered saline and the like. These solutions are sterile and generally free of undesirable matter. These compositions may be sterilized by conventional, well known sterilization techniques. The compositions may contain pharmaceutically acceptable auxiliary substances as required to approximate physiological conditions such as pH adjusting and buffering agents, toxicity adjusting agents and the like, e.g., sodium acetate, sodium chloride, potassium chloride, calcium chloride, sodium lactate and the like. The concentration of active agent in these formulations can vary widely, and will be selected primarily based on fluid volumes, viscosities, body weight, and the like in accordance with the particular mode of administration selected and the patient's needs. See, e.g., Remington's Pharmaceutical Science (15th ed., 1980) and Hardman and Limbird (eds. 2001) Goodman and Gillman: The Phannacological Basis of Therapeutics (10th ed.) McGraw-Hill. Thus, a typical pharmaceutical composition for intravenous administration would be about 0.1 to 10 mg per patient per day. Dosages from 0.1 up to about 100 mg per patient per day may be used, particularly when the drug is administered to a secluded site and not into the blood stream, such as into a body cavity or into a lumen of an organ. Substantially higher dosages are possible in topical administration. Actual methods for preparing parenterally administrable compositions are readily available. The compositions containing modulators of ovarian cancer proteins can be administered for therapeutic or prophylactic treatments. In therapeutic applications, compositions are administered to a patient suffering from a disease (e.g., a cancer) in an amount sufficient to cure or at least partially anest the disease and/or its complications. An amount adequate to accomplish this is defined as a "therapeutically effective dose." Amounts effective for this use will depend upon the severity ofthe disease and the general state ofthe patient's health. Single or multiple administrations ofthe compositions may be administered depending on the dosage and frequency as required and tolerated by the patient. In any event, the composition should provide a sufficient quantity ofthe agents of this invention to effectively treat the patient. An amount of modulator that is capable of preventing or slowing the development of cancer in a mammal is refened to as a "prophylactically effective dose."

The particular dose required for a prophylactic treatment will depend upon the medical condition and history ofthe mammal, the particular cancer being prevented, as well as other factors such as age, weight, gender, administration route, efficiency, etc. Such prophylactic treatments may be used, e.g., in a mammal who has previously had cancer to prevent a recunence ofthe cancer, or in a mammal who is suspected of having a significant likelihood of developing cancer based, e.g., in part, upon gene expression profiles. Vaccine strategies may be used, in either a DNA vaccine form, or protein vaccine. It will be appreciated that the present ovarian cancer protein-modulating compounds can be administered alone or in combination with additional ovarian cancer modulating compounds or with other therapeutic agent, e.g., other anti-cancer agents or treatments.

In numerous embodiments, one or more nucleic acids, e.g., polynucleotides comprising nucleic acid sequences set forth in Tables 1-26, such as RNAi, antisense polynucleotides or ribozymes, will be introduced into cells, in vitro or in vivo. The present invention provides methods, reagents, vectors, and cells useful for expression of ovarian cancer-associated polypeptides and nucleic acids using in vitro (cell- free), ex vivo or in vivo (cell or organism-based) recombinant expression systems.

The particular procedure used to introduce the nucleic acids into a host cell for expression of a protein or nucleic acid is application specific. Many procedures for introducing foreign nucleotide sequences into host cells may be used. These include the use of calcium phosphate transfection, spheroplasts, electroporation, liposomes, microinjection, plasma vectors, viral vectors and any ofthe other well known methods for introducing cloned genomic DNA, cDNA, synthetic DNA or other foreign genetic material into a host cell. See, e.g., Berger and Kimmel (1987) Guide to Molecular Cloning Techniques from Methods in Enzymology (vol. 152) Academic Press; Ausubel, et al. (eds. 1999 and supplements) Cunent Protocols Lippincott; and Sambrook, et al. (2001) Molecular Cloning: A Laboratory Manual (3d ed., Vol. 1-3) CSH Press.

In a prefened embodiment, ovarian cancer proteins and modulators are administered as therapeutic agents, and can be formulated as outlined above. Similarly, ovarian cancer genes (including both the full-length sequence, partial sequences, or regulatory sequences of the ovarian cancer coding regions) can be administered in a gene therapy application. These ovarian cancer genes can include antisense applications, either as gene therapy (e.g., for incorporation into the genome) or as antisense compositions, as will be appreciated by those in the art.

Ovarian cancer polypeptides and polynucleotides can also be administered as vaccine compositions to stimulate HTL, CTL, and antibody responses.. Such vaccine compositions can include, e.g., lipidated peptides (see, e.g., Vitiello, et al. (1995) J. Clin. Invest. 95:341- 349), peptide compositions encapsulated in poly(D,L-lactide-co-glycolide, "PLG") microspheres (see, e.g., Eldridge, et al. (1991) Molec. Immunol. 28:287-294; Alonso, et al. (1994) Vaccine 12:299-306; Jones, et al. (1995) Vaccine 13:675-681), peptide compositions contained in immune stimulating complexes (ISCOMS; see, e.g., Takahashi, et al. (1990) Nature 344:873-875; Hu, et al. (1998) Clin. Exp. Immunol. 113:235-243), multiple antigen . peptide systems (MAPs; see, e.g., Tarn (1988) Proc. Nat'l Acad. Sci. USA 85:5409-5413; Tarn (1996) J. Immunol. Methods 196:17-32), peptides formulated as multivalent peptides; peptides for use in ballistic delivery systems, typically crystallized peptides, viral delivery vectors (Perkus, et al., p. 379, in Kaufmann (ed. 1996) Concepts in Vaccine Development de Gruyter; Chakrabarti, et al. (1986) Nature 320:535-537; Hu, et al. (1986) Nature 320:537- 540; Kieny, et al. (1986) AIDS Bio/Technology 4:790-795; Top, et al. (1971) J. Infect. Dis. 124:148-154; Chanda, et al. (1990) Virology 175:535-547), particles of viral or synthetic origin (see, e.g., Kofler, et al. (1996) J. Immunol. Methods 192:25-35; Eldridge, et al. (1993) Sem. Hematol. 30:16-24; Falo, et al. (1995) Nature Med. 7:649-653), adjuvants (Wanen, et al. (1986) Ann. Rev. Immunol. 4:369-388; Gupta, et al. (1993) Vaccine 11 :293-306), liposomes (Reddy, et al.(1992) J. hnmunol. 148:1585-1589; Rock (1996) Immunol. Today 17:131-137), or, naked or particle absorbed cDNA (Ulmer, et al. (1993) Science 259:1745- 1749; Robinson, et al. (1993) Vaccine 11 :957-960; Shiver, et al., p. 423, in Kaufmann (ed. 1996) Concepts in Vaccine Development de Gruyter; Cease and Berzofsky (1994) Ann. Rev. hnmunol. 12:923-989; and Eldridge, et al. (1993) Sem. Hematol. 30: 16-24). Toxin-targeted delivery technologies, also known as receptor mediated targeting, such as those of Avant Immunotherapeutics, Inc. (Needham, Massachusetts) may also be used.

Vaccine compositions often include adjuvants. Many adjuvants contain a substance designed to protect the antigen from rapid catabolism, such as aluminum hydroxide or mineral oil, and a stimulator of immune responses, such as lipid A, Bortadella pertussis, or Mycobacterium tuberculosis derived proteins. Certain adjuvants are commercially available as, e.g., Freund's Incomplete Adjuvant and Complete Adjuvant (Difco Laboratories, Detroit, MI); Merck Adjuvant 65 (Merck and Company, Inc., Rahway, NJ); AS-2 (SmithKline Beecham, Philadelphia, PA); aluminum salts such as aluminum hydroxide gel (alum) or aluminum phosphate; salts of calcium, iron or zinc; an insoluble suspension of acylated tyrosine; acylated sugars; cationically or anionically derivatized polysaccharides; polyphosphazenes; biodegradable microspheres; monophosphoryl lipid A and quil A.

Cytokines, such as GM-CSF, interleukin-2, -7, -12, and other like growth factors, may also be used as adjuvants.

Vaccines can be administered as nucleic acid compositions wherein DNA or RNA encoding one or more ofthe polypeptides, or a fragment thereof, is administered to a patient. See, e.g., Wolff et. al. (1990) Science 247:1465-1468; U.S. Patent Nos. 5,580,859; 5,589,466; 5,804,566; 5,739,118; 5,736,524; 5,679,647; and WO 98/04720. Examples of DNA-based delivery technologies include "naked DNA", facilitated (bupivicaine, polymers, peptide- mediated) delivery, cationic lipid complexes, and particle-mediated ("gene gun") or pressure- mediated delivery (see, e.g., U.S. Patent No. 5,922,687).

For therapeutic or prophylactic immunization purposes, the peptides ofthe invention can be expressed by viral or bacterial vectors. Examples of expression vectors include attenuated viral hosts, such as vaccinia or fowlpox. This approach involves the use of vaccinia virus, e.g., as a vector to express nucleotide sequences that encode ovarian cancer polypeptides or polypeptide fragments. Upon introduction into a host, the recombinant vaccinia virus expresses the immunogenic peptide, and thereby elicits an immune response. Vaccinia vectors and methods useful in immunization protocols are described in, e.g., U.S. Patent No. 4,722,848. Another vector is BCG (Bacille Calmette Guerin). BCG vectors are described in Stover, et al. (1991) Nature 351 :456-460. A wide variety of other vectors useful for therapeutic administration or immunization e.g., adeno and adeno-associated virus vectors, retroviral vectors, Salmonella typhi vectors, detoxified anthrax toxin vectors, and the like, will be apparent. See, e.g., Shata, et al. (2000) Mol. Med. Today 6:66-71; Shedlock, et al. (2000) J. Leukoc. Biol. 68:793-806; and Hipp, et al. (2000) In Vivo 14:571-85.

Methods for the use of genes as DNA vaccines are well known, and include placing an ovarian cancer gene or portion of an ovarian cancer gene under the control of a regulatable promoter or a tissue-specific promoter for expression in an ovarian cancer patient. The ovarian cancer gene used for DNA vaccines can encode full-length ovarian cancer proteins, but more preferably encodes portions ofthe ovarian cancer proteins including peptides derived from the ovarian cancer protein. In one embodiment, a patient is immunized with a DNA vaccine comprising a plurality of nucleotide sequences derived from an ovarian cancer gene. For example, ovarian cancer-associated genes or sequence encoding subfragments of an ovarian cancer protein are introduced into expression vectors and tested for their immunogenicity in the context of Class I MHC and an ability to generate cytotoxic T cell responses. This procedure provides for production of cytotoxic T cell responses against cells wliich present antigen, including intracellular epitopes. In a prefened embodiment, the DNA vaccines include a gene encoding an adjuvant molecule with the DNA vaccine. Such adjuvant molecules include cytokines that increase the immunogenic response to the ovarian cancer polypeptide encoded by the DNA vaccine. Additional or alternative adjuvants are available. In another prefened embodiment ovarian cancer genes find use in generating animal models of ovarian cancer. When the ovarian cancer gene identified is repressed or diminished in cancer tissue, gene therapy technology, e.g., wherein antisense RNA directed to the ovarian cancer gene will also diminish or repress expression ofthe gene. Animal models of ovarian cancer find use in screening for modulators of an ovarian cancer- associated sequence or modulators of ovarian cancer. Similarly, transgenic animal technology including gene knockout technology, e.g., as a result of homologous recombination with an appropriate gene targeting vector, will result in the absence or increased expression ofthe ovarian cancer protein. When desired, tissue-specific expression or knockout ofthe ovarian cancer protein may be necessary. It is also possible that the ovarian cancer protein is overexpressed in ovarian cancer.

As such, transgenic animals can be generated that overexpress the ovarian cancer protein. Depending on the desired expression level, promoters of various strengths can be employed to express the transgene. Also, the number of copies ofthe integrated transgene can be determined and compared for a determination ofthe expression level ofthe transgene. Animals generated by such methods find use as animal models of ovarian cancer and are additionally useful in screening for modulators to treat ovarian cancer.

Kits for Use in Diagnostic and/or Prognostic Applications

For use in diagnostic, research, and therapeutic applications suggested above, kits are also provided by the invention. In the diagnostic and research applications such kits may include any or all ofthe following: assay reagents, buffers, ovarian cancer-specific nucleic acids or antibodies, hybridization probes and/or primers, siRNA or antisense polynucleotides, ribozymes, dominant negative ovarian cancer polypeptides or polynucleotides, small molecules inhibitors of ovarian cancer-associated sequences etc. A therapeutic product may include sterile saline or another pharmaceutically acceptable emulsion and suspension base.

In addition, the kits may include instructional materials containing directions (e.g., protocols) for the practice ofthe methods of this invention. While the instructional materials typically comprise written or printed materials they are not limited to such. Any medium capable of storing such instructions and communicating them to an end user is contemplated by this invention. Such media include, but are not limited to electronic storage media (e.g., magnetic discs, tapes, cartridges, chips), optical media (e.g., CD ROM), and the like. Such media may include addresses to internet sites that provide such instructional materials. The present invention also provides for kits for screening for modulators of ovarian cancer-associated sequences. Such kits can be prepared from readily available materials and reagents. For example, such kits can comprise one or more ofthe following materials: an ovarian cancer-associated polypeptide or polynucleotide, reaction tubes, and instructions for testing ovarian cancer-associated activity. Optionally, the kit contains biologically active ovarian cancer protein. A wide variety of kits and components can be prepared according to the present invention, depending upon the intended user ofthe kit and the particular needs of the user. Diagnosis would typically involve evaluation of a plurality of genes or products. The genes will be selected based on conelations with important parameters in disease which may be identified in historical or outcome data.

EXAMPLES

Example 1: Gene Chip Analysis Molecular profiles of various normal and cancerous tissues were determined and analyzed using gene chips. RNA was isolated and gene chip analysis was performed as described (Glynne, et al. (2000) Nature 403:672-676; Zhao, et al. (2000) Genes Dev. 14:981- 993).

TABLE 1 A lists about 1119 genes up-regulated in ovarian cancer compared to normal adult tissues. These were selected from 59000 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the ratio of "average" ovarian cancer to "average" normal adult tissues was greater than or equal to 5.0. The "average" ovarian cancer level was set to the 80th percentile value amongst various ovarian cancers. The "average" normal adult tissue level was set to the 85th percentile amongst various non-malignant tissues. TABLE 1A: ABOUT 1119 UP-REGULATED OVARIAN CANCER GENES

Pkey: Primekey

Ex. Accn: Exemplar Accession

UGID: UniGene lD

Title: UniGene title ratio: ratio tumor vs normal tissues

Pkey Ex. Accn UG ID Title ratio

423634 AW959908 Hs.1690 hepariπ-bindiπg growth factor binding protein 65.7

423017 AW178761 Hs.227948 "serine (orcysteinβ) proteinase inhibitor, clade B(ovalbumi 63.6

432938 T27013 Hs.3132 steroidogenic acute regulatory protein 58.3

445810 A 265700 Hs.155660 ESTs 35.9

431938 AA938471 Hs.115242 developmentally regulated GTP-binding protein 1 32.0

407112 AA070801 Hs.51615 "ESTs, Weakly similar to ALU7_HU AN ALU SUBFAM 31.3

425650 NM 01944 Hs.1925 desmoglein 3 (pemphigus vulgaris antigen) 30.0

402075 predicted exon 27.9

400301 X03635 Hs.1657 estrogen receptor 1 26.4 402639 predicted exon 25.3

421948 L42583 Hs.111758 keratin 6A 24.7

414540 BE379050 "gb:601236655F1 NIH_MGC_44 Homo sapiens cDNA clon 24.6

418994 AA296520 Hs.89546 selectin E (endothetial adhesion molecule 1) 24.5

401575 predicted exon 23.6

457024 AA397546 Hs.119151 ESTs 23.2

440684 AI253123 Hs.127356 "ESTs, Highly similar to NEST WMAN NESTI [H.sapieπ 23.1

459006 AW298631 Hs.27721 hypothetical protein FLJ20353 22.8

400964 predicted exon 22.5

402421 predicted exon 20.9

437329 AA811977 Hs.291761 ESTs 20.8

414605 BE390440 "gb:601283601F1 NIH MGC 44 Homo sapiens cDNA clon 20.7

411004 AW813242 "gb: R3-ST0191-020200-207-g10 ST0191 Homo sapiens 20.4

401283 predicted exon 20.3

440633 AI140686 Hs.263320 ESTs 19.9

445603 H08345 Hs.106234 ESTs 19.7

403786 predicted exon 19.7

436508 AW604381 Hs.121121 ESTs 19.6

459390 BE385725 "gb:601276347F1 NIH MGC 20 Homo sapiens cDNA clon 19.2

421823 N40850 Hs.28625 ESTs 19.0

417366 BE185289 Hs.1076 small proline-rich protein 16 (comifin) 18.9

422525 AA758797 Hs.192807 ESTs 18.5

458121 S42416 Hs.74647 Human T-cell receptor active alpha-chain mRNA from JM c 18.3

430520 NM_016190 Hs.242057 chromosome 1 open reading frame 10 18.1

450192 AA263143 Hs.24596 RAD51-interacting protein 18.0

416839 H94900 Hs.17882 ESTs 17.9

440788 AI806594 Hs.128577 ESTs 17.9

451072 AA013451 Hs.117929 ESTs 17.7

402203 predicted exon 17.3

417611 AW993983 "gb:RC1-BN0035-130400-013-a04 BN0035 Homo sapiens 17.3

438658 AI222068 Hs.123571 ESTs 17.3

403747 predicted exon 17.2

444958 AW292643 Hs.167047 ESTs 17.2

404097 predicted exon 17.1

459375 BE251770 "gb:601112470F1 NIH_MGC_16 Homo sapiens cDNAclon 16.9

443198 AI039813 gb:ox49dQ6.x1 Soares total fetus Nb2HF8 9 Homo sapi 16.9

441557 AW452647 Hs.270482 ESTs 16.9

433871 W02410 Hs.205555 ESTs 16.8

429163 AA884766 gb:am20a10.s1 Soares NFL T GBC S1 Homo sapiens cD 16.7

443406 AI056238 Hs.143316 ESTs 16.7

400613 predicted exon 16.6

448372 AW445166 Hs.170802 ESTs 16.5

410929 H47233 Hs.30643 ESTs 16.5

445887 A1263105 Hs.145597 ESTs 16.1

422036 AA302647 Hs.271891 ESTs 16.0

404767 predicted exon 15.9

420831 AA280824 Hs. 90035 ESTs 15.8

405196 predicted exon 15.8

452947 AW130413 "gb:xf50f04.x1 NCI_CGAP_Gas4 Homo sapiens cDNA o 15.8

429538 BE182592 Hs.139322 small proline-rich protein 3 15.8

435313 AI769400 Hs.189729 ESTs 15.7

449635 AI989942 Hs.232150 ESTs 15.6

424098 AF077374 Hs.139322 small proline-rich protein 3 15.4

411660 AW855718 "gb:RC1-CT0279-070100-021-a06 CT0279 Homo sapiens c 15.4

442653 BE269247 Hs.170226 Homo sapiens clone 23579 mRNA sequence 15.4

443534 AI076123 ^■ gb:oy92e04.x1 Soares fetal liver spleen 1NFLS_S1 Homo 15.4

458012 AI424899 Hs.188211 ESTs 15.3

441018 AI809587 Hs.148782 ESTs 15.1

425972 BE391563 Hs.165433 "ESTs, Highly similar to T17342 hypothetical protein DKFZ 15.1

418092 R45154 Hs.106604 ESTs 15.1

410909 AW898161 Hs.53112 "ESTs, Weakly similar to ALU8 HUMAN ALU SUBFAM 15.1

458234 BE551408 Hs.127196 ESTs 15.0

434208 T92641 Hs.127648 hypothetical protein PR02176 15.0

403177 predicted exon 15.0

423725 AJ403108 Hs.132127 hypothetical protein LOC57822 14.9

425090 AA350552 "gb:EST57886 Infant brain Homo sapiens cDNA 5' end, mR 14.7

409723 AW885757 Hs.257862 ESTs 14.6

423735 AA330259 "gb:EST33963 Embryo, 12 week II Homo sapiens cDNA 5' 14.6

444266 AI424984 Hs.125465 ESTs 14.5

443341 AW631480 Hs.8688 ESTs 14.4

457336 AW969657 Hs.291029 ESTs 14.4

440500 AA972165 Hs.150308 ESTs 14.4

446292 AF081497 Hs.279682 Rh type C glycoprotein 14.3

438086 AA336519 Hs.301167 "Homo sapiens cDNA: FU21545 fis, clone COL06195" 14.3

434715 BE005346 Hs.116410 ESTs 14.2

409387 AW384900 Hs.123526 ESTs 14.2

409272 AB014569 Hs.52526 KIAA0669 gene product 14.2

454913 AW841462 "gb:RC6-CN0014-080300-012-B09 CN0014 Homo sapiens 14.0

439846 T63959 Hs.228320 "Homo sapiens cDNA: FU23537 fis, clone LNG07690" 14.0

409695 AA296961 "gb:EST112514 Adrenal gland tumor Homo sapiens cDNA 13.9

422897 AA679784 Hs.4290 ESTs 13.9

404664 predicted exon 13.9

458829 AI557388 "gb:PT2.1 6 G03.r tumor2 Homo sapiens cDNA 3', mRNA 13.8

407327 AA487182 Hs.269414 ESTs 13.8 455435 AW939445 "gb QV1-DT0072-310100-056-.07 DT0072 Homo sapiens 137

449327 AI638743 Hs 224672 ESTs 137

411693 AW857271 "gb CM0-CT0307-210100-158-g09 CT0307 Homo sapiens 137

407463 AJ272034 gb Homo sapiens mRNA for putative capacitative calcium c 136

446767 AI380107 Hs 158954 ESTs 136

433040 H70423 Hs 300511 ESTs 135

435209 AW027809 Hs 187698 "ESTs, Highly similar to cytomegalovirus partial fusion rece 135

441459 AI919142 Hs 214233 ESTs 135

401269 predicted exon 134

438663 AI199575 Hs 153070 ESTs 134

426698 AA394104 Hs 97489 ESTs 134

423637 AL137279 Hs 130187 Homo sapiens mRNA, cDNA DKFZρ43401214 (from clon 132

448543 AW897741 Hs 21380 Homo sapiens mRNA, cDNA DKFZρ586P1124 (from clon 132

456714 AW897265 "gb CMO-NN0057-150400-335-a04 NN0057 Homo sapiens 13 2

458356 AI024855 Hs 131575 ESTs 132

431822 AA516049 "gb ng65d01 s1 NCI_CGAP_Lιp2 Homo sapiens cDNA do 131

454822 AW833793 "gb QV4-TT0008-130100-080-a06 TT0008 Homo sapiens c 131

453358 AI990738 Hs 240066 ESTs 131

435542 AA687376 Hs 269533 ESTs 131

421286 AA806584 Hs 187895 ESTs 130

452799 AI948829 Hs 213786 ESTs 130

444355 BE383686 Hs 191621 ESTs 130

444271 AW452569 Hs 149804 ESTs 129

443860 AW866632 "gb QV4-SN0024-Σ10400-181 -g04 SN0024 Homo sapiens 129

428719 AA358193 Hs 193128 hypothetical protein FLJ 10805 129

418282 AA215535 Hs 98133 ESTs 128

437308 AA749417 Hs 292353 ESTs 127

400584 predicted exon 127

426306 AA447310 Hs 164059 "Homo sapiens cDNA FU13338 fis, clone OVARC100188 127

448466 AI522109 Hs 171066 ESTs 127

402738 predicted exon 127

451531 AA018311 Hs 114762 ESTs 126

435243 AW292886 Hs 261373 adenosine A2b receptor pseudogene 126

431725 X65724 Hs 2839 Nome disease (pseudoglioma) 126

425108 AI000489 Hs 96967 ESTs 12 5

422330 D30783 Hs 115263 epiregulin 125

432949 AA570749 Hs 298866 ESTs 125

417009 AA191719 Hs 171872 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA 124

456378 AA843387 Hs 87279 ESTs 124

432966 AA650114 "gb ns92h09s1 NCI CGAP Pr3 Homo sapiens cDNA clon 124

440571 AA904461 Hs 130798 ESTs 12 3

411178 AW820852 "gb RC2-ST0301-120200 011-f12 ST0301 Homo sapiens c 123

445934 AF131737 Hs 13475 hypothetical protein 123

433917 AI809325 Hs 122814 Human DNA sequence from clone RP5-1028D 5 on chrom 122

402018 predicted exon 122

424101 AA335394 "gb EST39787 Epididymus Homo sapiens cDNA 5' end, R 122

448533 AL119710 Hs 21365 nucleosome assembly protein 1-lιke 3 12 1

458154 AW816379 "gb QV4-ST0234-181199-035-g01 ST0234 Homo sapiens c 121

440919 AW291274 Hs 262826 ESTs 120

415747 AA381209 "gb EST94257 Activated T-cells I Homo sapiens cDNA 5' e 120

411748 AW859920 "gb QV1-CT0364-260100 052-g05 CT0364 Homo sapiens 120

452975 M85521 Hs 69469 dendritic cell protein 120

427276 AA400269 Hs 49598 ESTs 120

454315 AW373564 Hs 251928 nuclear pore complex interacting protein 120

450786 H86632 Hs 33654 ESTs 120

402578 predicted exon 11 9

459591 AL037185 gb DKFZp564A1169_r1 564 (synonym hfbr2) Homo sapie 11 9

433449 AW772282 "gb hn71b05 x1 NCI CGAP Kιd11 Homo sapiens cDNA c 11 9

429108 AA890521 Hs 126035 ESTs 11 8

454556 AW807073 "gb MR4-ST0062-031199 018-d06 ST0062 Homo sapiens 11 7

443613 AI079356 gb oz39b09 s1 Soares_NhHMPu_S1 Homo sapiens cDNA c 11 7

400385 NM 020389 Hs 283104 putative capacitative calcium channel 11 6

411725 AW858396 "gb CMO CT0341-181299-130-c06 CT0341 Homo sapiens 11 5

455174 AI694575 Hs 147801 ESTs 11 5

412402 AW984788 "gb RC1-HN0015-120400-021-C07 HN0015 Homo sapiens 11 5

434205 AF119861 Hs 283032 hypothetical protein PRO2015 11 5

450496 AW449251 Hs 257131 ESTs 11 5

411149 N68715 Hs 269128 ESTs 11 5

414210 BE383592 •gb 601297871F1 NIH_MGC_19 Homo sapiens cDNAclon 11 4

409994 D86864 Hs 57735 acetyl LDL receptor, SREC 11 3

453845 AL157568 gb DKFZp761F0816_r1 761 (synonym hamy2) Homo sapi 11 3

404849 predicted exon 11 3

442824 BE178065 Hs 144081 ESTs 11 3

428548 AA430058 Hs 98649 EST 11 3

434804 AA649530 "gb ns44f05 s1 NCI_CGAP_Alv1 Homo sapiens cDNA o 11 3

430486 BE062109 Hs 241551 "chloπde channel, calcium activated, family member 2" 11 3

400174 predicted exon 11 2

424324 AA346316 "gb EST52440 Greater omeπtum tumor Homo sapiens cDN 11 2

447724 AW298375 Hs 24477 ESTs 11 2

457028 AW449838 Hs 97562 ESTs 11 2

429900 AA460421 Hs 30875 ESTs 11 2

452240 AI591147 Hs 61232 ESTs 11 2

458067 AA393603 Hs 36752 "Homo sapiens cDNA FU22834 fis, clone KAIA4314" 11 1

402222 predicted exon 11 1 446745 AW118189 Hs 156400 ESTs 11 1

453060 AW294092 Hs 21594 ESTs 11 1

443482 AW188093 Hs 250385 ESTs 11 1

436843 AA824588 "gb oc83d02 s1 NCI CGAP GCB1 Homo sapiens cDNA c 11 0

416320 H47867 Hs 34024 ESTs 11 0

435772 AA700019 Hs 132992 "ATP-biπding cassette, sub-family G (WHITE), member 5 ( 11 0

451542 AA018365 Hs 32713 ESTs 11 0

408522 AI541214 Hs 46320 "Small proline-nch protein SPRK [human, odontogeπic kera 11 0

414712 N88858comp Hs 77039 πbosomal protein S3A 109

411940 AW876686 "gb CM4-PT0031-180200-507-e05 PT0031 Homo sapiens c 109

408733 AW264812 Hs 254290 ESTs 109

452030 AL137578 Hs 27607 Homo sapiens mRNA, cDNA DKFZp564N2464 (from clon 109

458175 AW296024 Hs 150434 ESTs 109

400612 predicted exon 109

440159 AI637599 Hs 126127 ESTs 108

429443 AB028967 Hs 202687 "potassium voltage-gated channel, Shal-related subfamily, m 108

416319 AI815601 Hs 79197 "CD83 antigen (activated B lymphocytes, immunoglobulin s 108

405783 predicted exon 107

405708 predicted exon 107

433266 AI863224 Hs 288677 "Homo sapiens cDNA FLJ13872 fis, clone THYRO100132 106

456900 AA355442 Hs 169054 ESTs 106

432408 N39127 Hs 76391 "myxovirus (influenza) resistance 1, homolog of muπne (int 106

451702 AW665452 Hs 246503 ESTs 106

418179 X51630 Hs 1145 Wil s tumor 1 10 6

408987 H85615 gb yt03f11 r1 Soares retina N2b5HR Homo sapiens cDNA 106

405285 predicted exon 105

419276 BE165909 Hs 134682 "Homo sapiens cDNA FU23161 fis, clone LNG09730" 105

407287 AI678812 Hs 201658 "ESTs, Weakly similar to ALU4_HUMAN ALU SUBFAM 105

403065 predicted exon 105

414195 BE263293 "gb 601144881F2 NIH_MGC_19 Homo sapiens cDNA clon 104

454258 AI457286 Hs 143979 "ESTs, Weakly similar to KIAA1276 protein [H sapiens]" 104

412951 BE018611 Hs 251946 "Homo sapiens cDNA FLJ23107 fis, clone LNG07738" 104

428888 AA437010 Hs 266584 ESTs 104

440834 AA907027 Hs 128606 ESTs 104

437096 AA744406 "gb ny51h02 s1 NCI_CGAP_Pr18 Homo sapiens cDNA clo 104

400135 predicted exon 104

447849 AI538147 Hs 164277 ESTs 103

400593 predicted exon 103

427469 AA403084 Hs 269347 ESTs 103

402794 predicted exon 102

452743 AW965082 Hs 61455 ESTs 102

448983 AI611654 Hs 224908 ESTs 10 2

422696 AF242524 Hs 26323 hypothetical nuclear factor SBBI22 10 2

428949 AA442153 Hs 104744 "ESTs, Weakly similar to AF208855 1 BM 013 [H sapiens] 10 2

409191 AW818390 "gb RC1 -ST0278-160200-014-d 10 ST0278 Homo sapiens c 10 2

428493 AK001745 Hs 184628 hypothetical protein FLJ 10883 10 2

406076 AL390179 Hs 137011 Homo sapiens mRNA, cDNA DKFZp547P134 (from clone 10 2

410626 BE407727 "gb 601299771 F1 NIH_MGC_21 Homo sapiens cDNA clon 10 1

445835 AW290999 Hs 145534 chromosome 21 open reading frame 23 101

452507 AI904646 "gb QV-BT065-020399-103 BT065 Homo sapiens cDNA, m 101

433297 AV658581 Hs 282633 ESTs 101

426724 AA383623 Hs 293616 ESTs 100

436659 A1217900 Hs 144464 ESTs 100

405675 predicted exon 100

413466 BE141737 Hs 254105 "enolase 1, (alpha)" 100

447198 D61523 Hs 283435 ESTs 10 0

403306 NM 006825 Hs 74368 "transmembrane protein (63kD), endoplasmio reticulum/Go 10 0

413544 BE147225 "gb PM2-HT0225 031299-003-f 11 HT0225 Homo sapiens 99

437094 AW103746 Hs 136907 ESTs 99

401497 predicted exon 99

416203 H27794 Hs 269055 ESTs 99

426882 AA393108 Hs 97365 ESTs 99

454874 AW836407 "gb PM3-LT0031-301299 002-b09 LT0031 Homo sapiens 99

406702 Z20656 Hs 278432 "myosiπ, heavy polypeptide 6, cardiac muscle, alpha (cardio 99

404952 predicted exon 99

430691 C14187 Hs 103538 ESTs 99

444518 AI160278 Hs 146884 ESTs 98

416665 H72974 gb yu28a10 s1 Soares fetal liver spleen 1 NFLS Homo sapie 98

438691 AA906288 Hs 212184 ESTs 98

405636 predicted exon 98

437242 AA747538 Hs 187942 ESTs 98

425627 AF019612 Hs 297007 ESTs 98

452226 AA024898 Hs 296002 ESTs 98

418986 AI123555 Hs 81796 ESTs 98

441139 AW449009 Hs 126647 ESTs 97

427244 AA402400 Hs 178045 ESTs 97

423756 AA828125 "gb Od71a09 s1 NCI_CGAP_Ov2 Homo sapiens cDNA clo 97

457940 AL360159 Hs 30445 Homo sapiens mRNA full length insert cDNA clone EURO 96

443526 AW792804 Hs 134002 ESTs 96

440576 AW449775 Hs 126008 ESTs 96

419088 AI538323 Hs 77496 small nuclear nbonucleoprotein polypeptide G 96

454707 AW814989 "gb MR1-ST0206-170400-024-g05 ST0206 Homo sapiens 96

446252 AI283125 Hs 150009 ESTs 96

434374 AA631439 "gb np85d02 s1 NCI_CGAP_Thy1 Homo sapiens cDNA cl 96 403093 predicted exon 9.6

454633 AW811380 "gb:IL3-ST0143-290999-019-D05 ST0143 Homo sapiens c 9.6

407291 AA001464 gb:ze45b01.r1 Soares retina N2b4HR Homo sapiens cDNA 9.5

455203 AW865450 "gb:PM4-SN0020-010400-008-b09 SN0020 Homo sapiens 9.5

403647 predicted exon 9.5

401530 predicted exon 9.5

414281 BE269751 Hs.288995 hypothetical protein FU20813 9.5

411057 AW815098 "gb:QV4-ST0212-091199-023-f10 ST0212 Homo sapiens c 9.5

415953 H14425 Hs.27947 ESTs 9.5

450174 T82121 Hs.177285 ESTs 9.5

422949 AA319435 "gb:EST21657 Adrenal gland tumor Homo sapiens cDNA 5 9.5

402112 R58624 Hs.2186 eukaryotic translation elongation factor 1 gamma 9.5

457886 AA742279 Hs.293346 ESTs 9.4

458145 A1239457 Hs.130794 ESTs 9.4

452332 ^' AW014859 Hs.101657 ESTs 9.4

434950 AW974892 "gb:EST386997 MAGE resequences, MAGN Homo sapien 9.3

409601 AF237621 Hs.80828 keratin 1 (epidermolytic hyperkeratosis) 9.3

419968 X04430 Hs.93913 "interleukin 6 (interferon, beta 2)" 9.3

436211 AK001581 Hs.80961 "polymerase (DNA directed), gamma" 9.3

428412 AA428240 Hs.126083 ESTs 9.3

449441 AI656040 Hs.196532 ESTs 9.3

458771 AW295151 Hs.163612 ESTs 9.3

458543 AA213403 Hs.257542 ESTs 9.3

414257 AI828600 Hs.21124 "ESTs, Weakly similar to ALU8_HUMAN ALU SUBFAM 9.3

442826 AI018777 Hs.131241 ESTs 9.3

446740 AI611635 Hs.192605 ESTs 9.2

408938 AA059013 Hs.22607 ESTs 9.2

434157 AI538316 Hs.158451 ESTs 9.2

408774 AW270899 Hs.254569 ESTs 9.2

424268 AA397653 Hs.144339 Human DNA sequence from clone 495010 on chromosome 9.2

415715 F30364 "gb:HSPD20786 HM3 Homo sapiens cDNA clone S400009 9.1

405277 predicted exon 9.1

412167 AW897230 "gb:CM0-NN0057-150400-335-a11 NN0057 Homo sapiens 9.1

442771 AW409808 Hs.101550 ESTs 9.1

404898 predicted exon 9.1

401230 predicted exon 9.1

400623 predicted exon 9.1

418808 AI821836 Hs.10359 ESTs 9.1

436396 AI683487 Hs.299112 "Homo sapiens cDNA FLJ11441 fis, clone HEMBA100132 9.1

440466 AA885871 Hs.135727 ESTs 9.0

437568 AI954795 Hs.156135 ESTs 9.0

405382 predicted exon 9.0

435673 AF202961 Hs.284200 "Homo sapiens uncharacterized gastric protein ZG12P mRN 9.0

405848 predicted exon 9.0

437229 AW976005 "gb:EST388114 MAGE resequences, MAGN Homo sapien 9.0

417728 AW138437 Hs.24790 KIAA1573 protein 9.0

454597 AW809648 "gb:MR4-ST0124-261099-015-d01 ST0124 Homo sapiens 9.0

427093 AA398118 Hs.97579 ESTs 9.0

408000 L11690 Hs.620 bullous pemphigoid antigen 1 (230/240kD) 9.0

440556 AW206958 Hs.125968 ESTs 9.0

400163 predicted exon 8.9

420120 AL049610 Hs.95243 transcription elongation factor A (Sll)-like 1 8.9

417549 AA203651 gb:zx58f10.r1 Soares_fetalJiver_spleen_1NFLS_S1 Homo 8.9

406163 predicted exon 8.9

437918 AI761449 Hs.121629 ESTs 8.9

449419 R34910 Hs.119172 ESTs 8.9

434683 AW298724 Hs.202639 ESTs 8.9

418432 M14156 Hs.85112 insulin-like growth factor 1 (somatomedia C) 8.9

454590 AW809762 Hs.222056 "Homo sapiens cDNA FL111572 fis, clone HEMBA100337 8.8

454574 AW809109 "gb:MR4-ST0117-070100-027-a04 ST0117 Homo sapiens c 8.8

441433 AA933809 Hs.42746 ESTs 8.8

416858 AW979294 Hs.85634 ESTs 8.8

421978 AJ243662 Hs.110196 NICE-1 protein 8.8

451528 AA018297 Hs.35493 ESTs 8.8

408751 N91553 Hs.258343 ESTs 8.7

401862 predicted exon 8.7

417344 AW997313 "gb:RC2-BN0048-250400-018-f12 BN0048 Homo sapiens 8.7

454455 AW752710 "gb:IL3-CT0219-281099-024-A03 CT0219 Homo sapiens c 8.7

455592 BE008002 "gb:QVO-BN0147-290400-214-h04 BN0147 Homo sapiens 8.7

417650 T05870 Hs.100640 ESTs 8.7

456309 AA225423 "gb:nc24a12.r1 NCI CGAP_Pr1 Homo sapiens cDNA clon 8.7

432030 AI908400 Hs.143789 ESTs 8.7

421492 BE176990 Hs.104916 hypothetical protein FLJ21940 8.7

402576 predicted exon 8.7

426874 N67325 Hs.247132 ESTs 8.7

403334 predicted exon 8.7

408562 AI436323 Hs.31141 "Homo sapiens mRNA for KIAA1568 protein, partial eds" 8.7

439443 AF086261 Hs.127892 ESTs 8.7

428600 AW863261 Hs.15036 "ESTs, Highly similarto AF1613581 HSPC095 [H.sapiens 8.7

414539 BE379046 "gb:601236646F1 NIH_MGC 44 Homo sapiens cDNA clon 8.6

432527 AW975028 Hs.102754 ESTs 8.6

403273 predicted exon 8.6

452077 BE144949 "gb:RC2-HT0187-041099-011-d12 HT0187 Homo sapiens 8.6

444598 A1288830 Hs.149924 ESTs 8.6 434066 AF116649 Hs.283944 "Homo sapiens PRO0566 mRNA, complete eds" 8.6

429643 AA455889 Hs.187548 ESTs 8.6

432340 AA534222 gb:nj21d02.s1 NCI CGAP AA1 Homo sapiens cDNA clon 8.6

446142 AI754693 Hs.145968 ESTs 8.6

417412 X16896 Hs.82112 "interleukin 1 receptor, type I" 8.6

416913 AW934714 "gb:RC1-DT0001-031299-011-a11 DT0001 Homo sapiens 8.5

451318 AA029888 Hs.95071 ESTs 8.5

405547 predicted exon 8.5

423843 AA332652 "gb:EST36627 Embryo, 8 week I Homo sapiens cDNA 5' en 8.5

454145 AA046872 Hs.62798 ESTs 8.4

401200 predicted exon 8.4

404166 predicted exon 8.4

412761 AW995092 "gb:QVO-BN0041-030300-145-a10 BN0041 Homo sapiens 8.4

412333 AW937485 "gb:QV3-DT0044-221299-045-b09 DT0044 Homo sapiens 8.4

455092 BE152428 "gb:CM0-HT0323-151299-126-b04 HT0323 Homo sapiens 8.4

419281 H96452 Hs.42189 ESTs 8.4

446171 AI374927 gb:ta66c04.x1 Soares_total_fetus_Nb2HF8_9w Homo sapie 8.3

437362 AL359561 Hs.16493 hypothetical protein DKFZp762N2316 8.3

402631 predicted exon 8.3

458573 AV653838 Hs.295131 ESTs 8.3

439185 AF087976 Hs.233343 ESTs 8.3

445881 AI263029 Hs.210689 ESTs 8.3

449737 AI668581 Hs.246316 ESTs 8.3

401830 AJ004832 Hs.5038 neuropathy target esterase 8.3

421991 NM_014918 Hs.110488 KIAA0990 protein 8.3

416996 W91892 Hs.59609 ESTs 8.2

443626 AI540644 Hs.138479 "ESTs, Moderately similar to ALU7_HUMAN ALU SUBF 8.2

407471 D55644 gb:Human spleen PABL (pseudoautosomal boundary-like se 8.2

402664 predicted exon 8.2

417682 W69561 gb:zd47a08.r1 Soares fetal heart NbHH19W Homo sapien 8.2

424983 AI742434 Hs.169911 ESTs 8.2

434353 AA630863 Hs.131375 "ESTs, Weakly similar to ALUB HUMAN III! ALU CLAS 8.2

453448 AL036710 Hs.209527 ESTs 8.2

455121 BE156459 "gb:QV0-HT0368-040100-082-f06 HT0368 Homo sapiens 8.2

404270 predicted exon 8.

438297 AW515196 Hs.258238 "ESTs, Moderately similar to ALU1 HUMAN ALU SUBF

418122 R42778 Hs.22217 ESTs

419929 U90268 Hs.93810 cerebral cavernous malformations 1

400925 predicted exon

403350 predicted exon

426116 AA868729 Hs.144694 ESTs

441518 AW161697 Hs.294150 ESTs

421888 AA299780 Hs.121036 ESTs

402745 predicted exon

402071 predicted exon

444781 NM 014400 Hs.11950 GPI-anchored metastasis-associated protein homolog 8.0

430372 AI206173 Hs.211375 ESTs 8.0

449867 AI672379 Hs.73919 "clathrin, light polypeptide (Lcb)" 8.0

422174 AL049325 Hs.112493 Homo sapiens mRNA; cDNA DKFZp564D036 (from clone 8.0

413382 BE090689 "gb:RC1-BT0720-280300-011-f08 BT0720 Homo sapiens c 8.0

456502 AI798611 Hs.157277 ESTs 8.0

405336 predicted exon 8.0

405917 predicted exon 8.0

436007 AI247716 Hs.232168 ESTs 8.0

439192 AW970536 Hs.105413 ESTs 8.0

437724 AW444828 Hs.184323 ESTs 8.0

452755 AW138937 Hs.213436 ESTs 8.0

401781 predicted exon 7.9

406057 predicted exon 7.9

406289 AW068311 Hs.82582 "integrin, beta-like 1 (with EGF-like repeat domains)" 7.9

421459 AI821539 Hs.97249 ESTs 7.9

448251 BE280486 Hs.84045 "Homo sapiens cDNA FLJ11979 fis, clone HEMBB100128 7.9

429125 AA446854 Hs.271004 ESTs 7.9

440154 BE077129 Hs.126119 "Homo sapiens cDNA FLJ13273 fis, clone OVARC100101 7.9

413233 AW578713 Hs.47534 "ESTs, Weakly similar to ORF YKL201c [S.cerevisiae]" 7.9

438268 AA782163 Hs.293502 ESTs 7.9

452466 N84635 Hs.29664 Human DNA sequence from clone 682J15 on chromosome 6 7.9

441194 BE274581 "gb:601120870F1 NIH_MGC_20 Homo sapiens cDNA clon 7.9

425292 NM_005824 Hs.155545 37 kDa leucine-rich repeat (LRR) protein 7.9

445090 AW205208 Hs.147293 ESTs 7.9

431292 AA370141 Hs.251453 Human DNA sequence from clone 967N21 on chromosome 7.9

414266 BE267834 "gb:601124428F1 NIH MGC 8 Homo sapiens cDNA clone 7.8

407839 AA045144 Hs.161566 ESTs 7.8

456101 AA159478 gb:zo74d06.s1 Stratagene pancreas (937208) Homo sapiens 7.8

455853 BE147225 "gb:PM2-HT0225-031299-003-f11 HT0225 Homo sapiens 7.8

414995 C18200 gb:C18200 Human placenta cDNA (TFujiwara) Homo sapie 7.8

447247 AW369351 Hs.287955 "Homo sapiens cDNA FU13090 fis, clone NT2RP3002142 7.8

416151 T26661 "gb:AB65C7R Infant brain, LLNL array of Dr. M. Soares 1 7.8

446435 AW206737 Hs.253582 ESTs 7.8

403698 predicted exon 7.8

424914 AA348410 Hs.119065 ESTs 7.8

409731 AA125985 Hs.56145 "thymosiπ, beta, identified in neuroblastoma cells" 7.8

401604 predicted exon 7.8

413025 AA805265 Hs.291646 ESTs 7.8 405896 predicted exon 7.8

454505 AW801365 "gb:IL5-UM0067-240300-050-a01 UM0067 Homo sapiens 7.7

448283 AI340462 Hs.182979 ribosomal protein L12 7.7

434098 AA625499 "gb:af69g08.r1 Soares NhHMPu S1 Homo sapiens cDNA 7.7

431673 AW971302 Hs.293233 ESTs 7.7

421029 AW057782 Hs.293053 ESTs 7.7

408391 AW859276 "gb:MR1-CT0352-240200-105-d02 CT0352 Homo sapiens 7.7

422529 AW015128 Hs.256703 ESTs 7.7

454389 AW752571 "gb:IL3-CT0213-170100-055-F02 CT0213 Homo sapiens c 7.7

427821 AA470158 Hs.98202 ESTs 7.7

434657 AA641876 Hs.191840 ESTs 7.7

445628 AI344166 Hs.155743 ESTs 7.7

424872 AA347923 "gb:EST54302 Fetal heart II Homo sapiens cDNA 5' end, m 7.7

439232 N48590 Hs.46693 ESTs 7.7

441417 AI733297 Hs.144474 ESTs 7.7

453596 AA441838 Hs.62905 ESTs 7.7

430440 X52599 Hs.2561 "nerve growth factor, beta polypeptide" 7.7

413306 AW303544 Hs.118654 ESTs 7.7

400968 predicted exon 7.7

446726 AW300144 Hs.209209 "Homo sapiens cDNA FLJ11629 fis, clone HEMBA100424 7.7

427504 AA776743 Hs.191589 ESTs 7.7

405621 predicted exon 7.6

414127 AI431863 Hs.135270 ESTs 7.6

409866 AW502152 gb:UI-HF-BROp-ajr-f-11-0-UI. NIH MGC 52 Homo sap 7.6

446232 AI281848 Hs.165547 ESTs 7.6

403568 predicted exon 7.6

451458 AI797558 Hs.270820 ESTs 7.6

439157 AA912737 Hs.20160 ESTs 7.6

401793 predicted exon 7.6

429839 AI190291 Hs.112143 ESTs 7.6

445672 AI907438 Hs.282862 ESTs 7.6

449444 AW818436 Hs.23590 "solute carrier family 16 (monocarboxylio acid transporters) 7.6

447499 AW262580 Hs.147674 KIAA1621 protein 7.6

421773 W69233 Hs.112457 ESTs 7.6

439706 AW872527 Hs.59761 ESTs 7.5

432189 AA527941 "gb:nh30c04.s1 NCI_CGAP_Pr3 Homo sapiens cDNA clon 7.5

402050 predicted exon 7.5

429687 AI675749 Hs.211608 nucleoporin 153kD 7.5

423193 R07299 Hs.254837 "Homo sapiens cDNA FLJ13502 fis, clone PLACE1004836 7.5

416548 H62953 gb:yr47f06.r1 Soares fetal liver spleen 1 NFLS Homo sapien 7.5

443236 AI079496 Hs.134169 ESTs 7.5

436053 AI057224 Hs.15443 ESTs 7.4

437191 NM_006846 Hs.5476 "serine protease inhibitor, Kazal type, 5" 7.4

451829 AW964081 Hs.247377 ESTs 7.4

443151 AI827193 Hs.132714 ESTs 7.4

452055 AI377431 Hs.293772 ESTs 7.4

445265 AI218295 Hs.144942 ESTs 7.4

401032 predicted exon 7.4

448184 BE541249 Hs.109697 ESTs 7.4

414808 T95945 gb:ye42e02.r1 Soares fetal liver spleen 1 NFLS Homo sapien 7.4

418540 AI821597 Hs.90877 "ESTs, Weakly similar to ALU1_HUMAN ALU SUBFAM 7.4

410449 AW748954 Hs.18192 Ser/Arg-related nuclear matrix protein (plenty of pralines 1 7.4

435568 AA688048 Hs.294080 ESTs 7.4

459160 AI904723 "gb:CM-BT066-120299-092 BT066 Homo sapiens cDNA, 7.4

419753 N42531 gb:yy11c12.r1 Soares melanocyte 2NbHM Homo sapiens cD 7.4

432383 AK000144 Hs.274449 "Homo sapiens cDNA FLJ20137 fis, clone COL07137" 7.4

404893 predicted exon 7.4'

425349 AA425234 Hs.79886 ribose 5-phosphate isomerase A (ribose 5-phosphate epimer 7.4

413864 BE175582 "gb:RC5-HT0580-100500-022-C01 HT0580 Homo sapiens 7.3

426871 AA393041 Hs.216493 ESTs 7.3

415613 R20233 gb:yg18h11.r1 Soares infant brain 1NIB Homo sapiens cDN 7.3

427025 AA397589 Hs.97523 ESTs 7.3

444683 AI375101 Hs.158721 "ESTs, Weakly similar to ALU1_HUMAN ALU SUBFAM 7.3

447700 AI420183 Hs.171077 "ESTs, Weakly similar to similar to serine/threonine kinase 7.3

412740 AW993984 "gb:RC1-BN0035-130400-013-a05 BN0035 Homo sapiens 7.3

416642 T96118 Hs.226313 "ESTs, Weakly similar to ALU1 HUMAN ALU SUBFAM 7.3

416506 H59879 Hs.237306 ESTs 7.3

426130 AA853282 gb:NHTBCae04f07r1 Normal Human Trabecular Bone Cell 7.3

407392 AB032369 "gb:Homo sapiens MIST mRNA, partial eds." 7.3

432365 AK001106 Hs.274419 hypothetical protein FU10244 7.3

451221 AI949701 Hs.210589 ESTs 7.3

443161 AI038316 gb:ox48c08.x1 Soares Jotal_fetus_Nb2HF8_9w Homo sapi 7.3

418186 BE541042 Hs.23240 "Homo sapiens cDNA FLJ13496 fis, clone PLACE1004471 7.3

439152 H65014 gb:yu66f10.r1 Weizmann Olfactory Epithelium Homo sapie 7.2

459534 BE386808 Hs.147905 ESTs 7.2

443326 BE156494 Hs.188478 ESTs 7.2

417351 T90278 Hs.15049 ESTs 7.2

454182 AW177335 "gb:CM1-CT0129-180899-006-b08 CT0129 Homo sapiens 7.2

402298 predicted exon 7.2

458562 N34128 Hs.145268 ESTs 7.2

407021 U52077 "gb:Humaπ marinerl transposase gene, complete consensus 7.2

449276 AW241510 Hs.252713 ESTs 7.2

418251 AA832123 Hs.177723 ESTs 7.2

420788 AA937957 Hs.193367 ESTs 7.2 401881 predicted exon 7.2

456436 AA251079 Hs.158386 ESTs 7.2

413425 F20956 "gb:HSPD05390 HM3 Homo sapiens cDNA clone 032-X4- 7.2

448966 AW372914 Hs.287462 "Ho o sapiens cDNA FU11875 fis, clone HEMBA100707 7.2

429340 N35938 Hs.199429 Homo sapiens mRNA; cDNA DKFZp434M2216 (from clon 7.2

406053 predicted exon 7.2

405851 predicted exon 7.2

431009 BE149762 Hs.248213 "gap junction protein, beta 6 (conπexiπ 30)" 7.2

426662 AA879474 Hs.122710 ESTs 7.2

408536 AW381532 Hs.135188 ESTs 7.1 .

455013 BE073250 "gb:MRO-BT0551-060300-102-e05 BT0551 Homo sapiens 7.1

428910 W03667 Hs.193792 ESTs 7.1

424634 NM 003613 Hs.151407 "cartilage intermediate layer protein, nucleotide pyrophosph 7.1

449794 AW444502 Hs.256982 "ESTs, Highly similar to AF116865 1 hedgehog-interacting 7.1

423410 AF058989 Hs.128231 "G antigen, family B, 1 (prostate associated)" 7.1

445460 AI797473 Hs.209468 ESTs 7.1

447285 AI371849 Hs.200696 "ATPase, Class VI, type 11C" 7.1

419750 AL079741 Hs.183114 "Homo sapiens cDNA FU14236 fis, clone NT2RP4000515 7.1

438986 AF085888 Hs.269307 ESTs 7.1

420757 X78592 Hs.99915 androgen receptor (dihydrotestosterone receptor; testicular 7.1

432479 AL042844 Hs.275675 katanin pβO (WD4Q-containing) subunit B 1 7.1

449733 R74546 Hs.29438 "Homo sapiens cDNA FLJ12094 fis, clone HEMBB100260 7.1

437846 AA773866 Hs.244569 ESTs 7.1

454934 AW846080 "gb:MR3-CT0176-081099-002-b09 CT0176 Homo sapiens 7.1

421929 AA300543 Hs.247360 ESTs 7.1

401780 predicted exoή 7.0

448106 AI800470 Hs.171941 ESTs 7.0

448835 BE277929 Hs.11081 "ESTs, Weakly similar to S57447 HPBRII-7 protein [H.sap 7.0

400842 predicted exon 7.0

429364 AA451797 Hs.201202 "ESTs, Moderately similar to Pro-Pol-dUTPase polyprotein 7.0

454963 AW847647 "gb:IL3-CT0213-280100-056-A06 CT0213 Homo sapiens c 7.0

423891 AK002042 Hs.134795 "Homo sapiens cDNA FLJ11180 fis, clone PLACE1007452 7.0

407506 U71600 "gb:Human zinc finger protein zfp31 (zf31) mRNA, partial 7.0

413802 AW964490 Hs.32241 ESTs 7.0

440051 BE559980 "gb:601345293F1 NIH MGC 8 Homo sapiens cDNA clone 7.0

446283 AI948801 Hs.171073 ESTs 7.0

419236 AA330447 Hs.135159 "Homo sapiens cDNA FLJ11481 fis, clone HEMBA100180 7.0

405472 predicted exon 7.0

435024 AI863518 Hs.127743 "ESTs, Weakly similar to V-ATPase G-subunit like protein 7.0

453969 AW090783 Hs.301731 "Homo sapiens cDNA FLJ11738 fis, clone HEMBA100547 7.0

404992 predicted exon 7.0

428129 AI244311 Hs.26912 ESTs 7.0

414315 Z24878 "gb:HSB65D052 STRATAGENE Human skeletal muscle cD 7.0

400491 H25530 Hs.50868 "solute earner family 22 (organic cation transporter), memb 6.9

459275 AI808913 Hs.118321 ESTs 6.9

450853 AA479629 Hs.44243 ESTs 6.9

457460 AI143312 Hs.164004 ESTs 6.9

434168 A1204525 Hs.116156 ESTs 6.9

445153 AI214671 "gb:qm32d02.x1 NCI_CGAP Lu5 Homo sapiens cDNA clo 6.9

450028 AI912012 Hs.200737 ESTs 6.9

414954 D81402 gb:HUM162A03B Human fetal brain (TFujiwara) Homosa 6.9

459478 AW195566 Hs.253182 ESTs 6.9

426269 H15302 Hs.168950 Homo sapiens mRNA; cDNA DKFZp566A1046 (from clon 6.9

401050 predicted exon 6.9

447588 AI394154 Hs.279659 "ESTs, Weakly similar to unknown protein [H.sapiens]" 6.9

449002 AI620018 Hs.117461 ESTs 6.9

452759 AW590773 Hs.258996 ESTs 6.9

443220 R85304 Hs.132032 "Homo sapiens cDNA FLJ11683 fis, clone HEMBA100490 6.9

400749 predicted exon 6.8

406277 predicted exon 6.8

433785 BE044593 Hs.112704 ESTs 6.8

434129 AI807757 Hs.221041 ESTs 6.8

453369 BE551550 Hs.232630 ESTs 6.8

411722 AW875942 "gb:CM1-PT0013-131299-067-b10 PT0013 Homo sapiens 6.8

455152 AW858621 "gb:CM0-CT0342-021299-115-f04 CT0342 Homo sapiens 6.8

412670 AA115456 gb:zk89b05.r1 Soares_pregnant_uterus_NbHPU Homo sapi 6.8

419054 N40340 Hs.191510 "ESTs, Weakly similar to ORF2 [M.musculus]" 6.8

421316 AA287203 Hs.251397 SMA5 6.8

432363 AA534489 gb:nf76g11.s1 NCI_CGAP_Co3 Homo sapiens cDNA clone 6.8

458603 AW103046 Hs.6162 KIAA0771 protein 6.8

439527 AW298119 Hs.202536 ESTs 6.8

408920 AL120071 Hs.48998 fibronectin leucine rich transmembrane protein 2 6.8

439127 AW978465 Hs.292368 ESTs 6.8

434890 AF161345 Hs.283930 "Homo sapiens HSPC082 mRNA, partial eds" 6.8

429413 NM 014058 Hs.201877 DESC1 protein 6.7

407788 BE514982 Hs.38991 S100 calcium-binding protein A2 6.7

447252 R90916 gb:yn01e10.r1 Soares adult brain N2b4HB55Y Homo sapien 6.7

455851 BE146879 "gb:QV4-HT0222-261099-014-c11 HT0222 Homo sapiens 6.7

439509 AF086332 Hs.58314 ESTs 6.7

418858 AW961605 Hs.21145 "Homo sapiens cDNA: FU22489 fis, clone HRC10951" 6.7

419323 AI092379 Hs.135275 ESTs 6.7

415317 Z43388 Hs.5570 hypothetical protein FU10006 6.7

418654 AA226334 Hs.154291 ESTs 6.7

407413 AF067801 "gb:Homo sapiens HDCGC21P mRNA, complete eds." 6.7 439694 AA843915 Hs.54707 ESTs 6.7

451191 N67900 Hs.118446 ESTs 6.7

454006 U12775 Hs.37006 agouti (mouse)-signaling protein 6.7

443657 R14973 gb:yf42f10.s1 Soares fetal liver spleen 1NFLS Homo sapien 6.7

455879 BE153275 "gb:PMO-HT0335-180400-008-e11 HT0335 Homo sapiens 6.7

451368 BE242152 Hs.288417 protein serine threonine kinase Clk4 6.7

453509 AL040021 gb:DKFZp434N1812_r1 434 (synonym: htes3) Homo sapie 6.7

420892 AW975076 Hs.172589 nuclear phosphoprotein similar to S. cerevisiae PWP1 6.7

423372 AI246375 Hs.154458 ESTs 6.7

450316 W84446 Hs.17850 ESTs 6.7

447795 AW295151 Hs.163612 ESTs 6.7

413252 BE074910 "gb:RC£BT0580-170300-021-F12 BT0580 Homo sapiens 6.7

405771 predicted exon 6.6

411483 AW848115 "gb:IL3-CT0214-301299-048-C09 CT0214 Homo sapiens c 6.6

420271 AI954365 Hs.42892 ESTs 6.6

431948 AA917706 Hs.194616 ESTs 6.6

409629 AW449589 Hs.279724 ESTs 6.6

458841 W28965 gb:54d10 Human retina cDNA randomly primed sublibrary 6.6

416565 AW000960 Hs.44970 ESTs 6.6

409097 AA677927 Hs.144269 ESTs 6.6

441832 AI018249 Hs.128062 ESTs 6.6

457285 AI038858 Hs.228780 "ESTs, Highly similar to AF19959 1 A-type potassium cha 6.6

406504 predicted exon 6.6

414606 BE387771 "gb:601283251 F1 NIH MGC 44 Homo sapiens cDNA clon 6.6

452956 AW003578 Hs.231872 ESTs 6.6

410743 AA089474 Hs.272153 ESTs 6.6

404599 predicted exon 6.6

423575 C18863 Hs.163443 "Homo sapiens cDNA FU11576 fis, clone HEMBA100354 6.6

443027 AIQ27847 Hs.253550 ESTs 6.6

458663 AV658444 Hs.280776 'Homo sapiens cDNA FU13684 fis, clone PLACE2000021 6.6

431277 AA501806 Hs.249965 ESTs 6.6

445232 BE294357 •gb:601172878F1 NIH_MGC_17 Homo sapiens cDNA clon 6.6

459170 AI905518 "gb:RC-BT091-210199-098 BT091 Homo sapiens cDNA, m 6.6

437876 AA770151 Hs.126424 ESTs 6.6

406752 AI285598 Hs.217493 annexin A2 6.6

401245 predicted exon 6.6

446102 AW168067 Hs.252956 ESTs 6.5

446989 AK001898 Hs.16740 hypothetical protein FU 11036 6.5

421160 AL080215 Hs.102301 Homo sapiens mRNA; cDNA DKFZp586J0323 (from clone 6.5

458831 • H71739 Hs.200227 ESTs 6.5

408914 AW450309 gb:Ul-H-BI3-akz-g-08-0-Ul.s1 NCI_CGAP_Sub5 Homo sa 6.5

411018 AW813428 "gb:MR3-ST0192-010200-210-c05 ST0192 Homo sapiens c 6.5

436562 H71937 Hs.169756 "complement component 1 , s subcomponent" 6.5

457620 AA602711 "gb:np03h06.s1 NCI CGAP Pr2 Homo sapiens cDNA clon 6.5

438647 AA813118 Hs.163230 ESTs 6.5

439570 T79925 Hs.269165 ESTs 6.5

419273 BE271180 Hs.293490 ESTs 6.5

443745 AB039670 Hs.9728 ALEX1 protein 6.5

431029 BE392725 Hs.248571 Homo sapiens PAC clone RP5-1163J12 from 7q21.2-q31.1 6.5

458695 AV660159 Hs.282284 ESTs 6.5

410966 AW812088 "gb:RC4-ST0173-191099-032-a07 ST0173 Homo sapiens c 6.4

417135 AA422067 Hs.50547 ESTs 6.4

416441 BE407197 "gb:601301552F1 NIH MGC 21 Homo sapiens cDNA clon 6.4

413702 BE170313 "gb:QV4-HT0536-040500-193-g02 HT0536 Homo sapiens 6.4

452563 AI907552 "gb:RC-BT147-120499-044 BT147 Homo sapiens cDNA, m 6.4

408956 AK001868 Hs.295306 "ESTs, Highly similar to unnamed protein product [H.sapien 6.4

406349 predicted exon 6.4

425420 BE536911 Hs.234545 "ESTs, Weakly similar to AF1551351 novel retinal pigmen 6.4

459430 AW662886 gb:hi82h11.x1 Soares_NFL_T_GBC_S1 Homo sapiens cDN 6.4

425733 F13287 Hs.159388 Homo sapiens clone 23578 mRNA sequence 6.4

458678 AI306162 Hs.170938 "ESTs, Weakly similar to K1AA0705 protein [H.sapiens]" 6.4

429695 AA835714 Hs.293556 ESTs 6.4

426872 AA410446 Hs.112011 "ESTs, Weakly similar to unknown [H.sapiens]" 6.4

437152 AL050027 gb:Homo sapiens mRNA; cDNA DKFZp566C0324 (from c 6.4

440517 AW139632 Hs.132246 ESTs 6.4

450877 A1799608 ι Hs.29178 ESTs 6.4

410664 NMJ06033 Hs.65370 "lipase, eπdothelial" 6.4

405793 predicted exon 6.4

418709 AA227394 gb:zr17c10.r1 Stratagene NT2 neuronal precursor 937230 H 6.4

428684 AA431792 Hs.44784 ESTs 6.4

448516 AW898595 "gb:RC1-NN0073-260400-011-g09 NN0073 Homo sapiens 6.4

400983 predicted exon 6.3

422365 AF035537 Hs.115521 "REV3 (yeast homolog)-like, catalytic subunit of DNA poly 6.3

425612 BE004257 "gb:CMO-BN0103-180300-296-c04 BN0103 Homo sapiens 6.3

401521 predicted exon 6.3

430290 AI734110 Hs.136355 ESTs 6.3

414931 AK000342 Hs.77646 Homo sapiens mRNA; cDNA DKFZp761 0223 (from clon 6.3

437939 AW298600 Hs.141840 "ESTs, Weakly similar to S59501 interferon receptor JFNA 6.3

451842 AI820539 Hs.267087 "ESTs, Moderately similar to ALU4_HUMAN ALU SUBF 6.3

405810 predicted exon 6.3

443747 AV646352 "gb:AV646352 GLC Homo sapiens cDNA clone GLCAME 6.3

427287 NM_014903 Hs.174188 KIAA0938 protein 6.3

413521 BE145814 "gb:MR0-HT0208-101299-202-a04 HT0208 Homo sapiens 6.3

429090 AW820278 Hs.99066 ESTs 6.3 451488 H22999 Hs 208846 ESTs 63

455713 BE069891 "gb QV4-BT0401-201299 064-b01 BT0401 Homo sapiens 63

452161 R43077 Hs 221747 ESTs 63

428647 AA830050 Hs 124344 ESTs 63

445063 AI246275 Hs 149196 ESTs 63

456671 AB011142 Hs 114293 KIAA0570 gene product 63

401508 predicted exon 63

412677 AW029608 Hs 17384 ESTs 63

441720 AI346487 Hs 28739 ESTs 63

418051 AW192535 Hs 19479 ESTs 63

438014 N71183 Hs 121806 "Homo sapiens cDNA FLJ11971 fis, clone HEMBB100120 63

432101 AI918950 Hs 1092 "Homo sapiens cDNA FU14290 fis, clone PLACE1006795 63

421032 AW293133 Hs 101340 ESTs 63

436532 AA721522 "gb nv54h12 r1 NCLCGAP Ew1 Homo sapiens cDNA clo 63

431318 AA502700 Hs 293147 ESTs 63

413470 N20934 gb yx54c1 si Soares elanocyte 2NbHM Homo sapiens c 63

402425 predicted exon 63

455993 BE179085 "gb RCO-HT0613-140300 021-d06 HT0613 Homo sapiens 63

400160 predicted exon 63

413795 AL040178 Hs 142003 ESTs 62

405071 predicted exon 62

403741 predicted exon 62

432489 AI804855 Hs 207530 ESTs 62

402296 predicted exon 62

446091 AW022192 Hs 200197 ESTs 62

444788 AI871122 Hs 202821 ESTs 62

404972 predicted exon 62

400227 predicted exon 62

433804 AI936561 Hs 112740 ESTs 62

448807 AI571940 Hs 7549 ESTs 62

404340 predicted exon 62

424632 AB014523 Hs 151406 KIAA0623 gene product 62

449547 H93543 Hs 117963 ESTs 62

406945 K01383 Hs 203967 etallothionein 1 A (functional) 62

433663 AF083131 Hs 229535 CATX-15 protein 62

407809 AW082279 Hs 244106 ESTs 62

418342 BE002723 Hs 293504 "ESTs, Moderately similar to ALU1_HUMAN ALU SUBF 62

438007 AA133008 Hs 158675 nbosomal protein L1 62

410536 N39533 gb yv27d04 s1 Soares fetal liver spleen 1 NFLS Homo sapie 62

448005 AW207437 Hs 170378 ESTs 62

414083 AL121282 Hs 257786 ESTs 62

405362 predicted exon 62

410102 AW248508 Hs 279727 "Homo sapiens cDNA FLJ14035 fis, clone HEMBA100463 62

457868 AW975133 "gb EST387239 MAGE resequences, MAGN Homo sapien 62

407395 AF005082 "gb Homo sapiens skin specific protein (xp33) mRNA part 62

443603 BE502601 Hs 134289 "ESTs, Weakly similar to KIAA1063 protein [H sapiens]" 62

430051 AA464611 Hs 52515 transducm (beta) like 2 61

434569 AI311295 Hs 58609 ESTs 6 1

430481 AA479678 Hs 203269 "ESTs, Moderately similar to ALU8_HUMAN ALU SUBF 6 1

402859 predicted exon 61

401260 predicted exon 61

406544 predicted exon 6 1

428446 AI024600 Hs 98612 ESTs 61

412246 AI160873 Hs 69233 "ESTs, Weakly similar to KIAA1064 protein [H sapiens]" 61

400420 AJ277247 Hs 287369 interleuk 22 61

455662 BE065387 "gb RC1-BT0314-030500-016-d03 BT0314Homo sapiens 61

428613 AB037749 Hs 186928 KIAA1328 protein 61

443267 AW450630 Hs 133851 ESTs 61

433405 AW157566 Hs 156892 ESTs 61

416795 AI497778 Hs 168053 "ESTs, Highly similar to AF2279481 HBV pX associated p 61

435706 W31254 Hs 7045 GL004 protein 61

450769 AA057418 Hs 33654 ESTs 6 1

427174 AA398848 Hs 97541 ESTs 61

425389 AW974499 Hs 192183 ESTs 6 1

416675 H73802 Hs 35381 ESTs 6 1

432749 NM_014438 Hs 278909 lnterIeukιn-1 Superfamilye 61

401809 predicted exon 6 1

403041 predicted exon 60

408523 AW833259 "gb RC2-TT0007-131099-011-c01 TT0007 Homo sapiens c 60

416515 N91716 Hs 194140 ESTs 60

452591 BE173164 Hs 1516 insulin like growth factor binding protein 4 60

437146 AA730977 "gb nw55f05 s1 NC!_CGAP_Ew1 Homo sapiens cDNA clo 60

450094 AI174947 Hs 295789 Homo sapiens mRNA, cDNA DKFZp564D1164 (from clon 60

402529 predicted exon 60

430706 NM 003540 Hs 247816 "H4 histone family, member C" 60

459186 AI908287 "gb RC-BT168-020499 035 BT168 Homo sapiens cDNA, m 60

452158 AI699120 Hs 61198 ESTs 60

411237 AW833676 "gb QV4-TT0008-181199 038-h04TT0008 Homo sapiens 60

400441 M15530 Hs 99879 B-cell growth factor 1 (12kD) 60

439398 AA284267 Hs 221504 ESTs 60

440862 H39048 Hs 127432 ESTs 60

415451 H19415 Hs 268720 "ESTs, Moderately similar to ALU1_HUMAN ALU SUBF 60

459587 AA031956 gb zk15e04 s1 Soares_pregnantjiterus_NbHPU Homo sapi 60

456072 H54381 gb yq89a03 s1 Soares fetal liver spleen 1NFLS Homo sapie 60 409954 AW512770 Hs 266457 ESTs 60

443488 A1073495 Hs 133912 "ESTs, Weakly similar to methyl CpG binding domam-cont 60

430825 AI734186 Hs 185105 ESTs 60

454466 AA984138 Hs 279895 "Homo sapiens mRNA for KIAA1578 protein, partial eds" 60

456506 AA278277 Hs 194212 ESTs 60

449228 AJ403107 Hs 148590 "ESTs, Weakly similar to AF208846 1 BM 004 [H sapiens] 60

457727 AW974687 "gb EST386776 MAGE resequences, MAGM Homo sapien 60

442440 BE464435 Hs 146180 "ESTs, Weakly similar to non receptor protein tyrosine kma 59

455110 BE154505 "gb PM0-HT0343-281299 003-e06 HT0343 Homo sapiens 59

402790 predicted exon 59

409982 BE005839 "gb RC2 BN0120-250400-012-f03 BN0120 Homo sapiens 59

427635 BE397988 Hs 179982 tumor protein p53-bιndιng protein 59

408948 AW296713 Hs 221441 ESTs 59

402046 predicted exon 5 9

416438 R89238 Hs 34262 ESTs 5 9

403083 predicted exon 5 9

402481 predicted exon 5 9

409867 AW502161 gb UI HF BROp-ajr-g-12-O-UI r1 NIH_MGC_52 Homo sap 59

420362 U79734 Hs 97206 huntingtm interacting protein 1 5 9

421375 AA489200 Hs 100595 "ESTs, Moderately similar to ALU HUMAN ALU SUBF 59

437630 AI252782 Hs 153029 ESTs 59

443500 AV646388 Hs 137071 ESTs 5 9

448995 AI613276 Hs 5662 "guanine nucleotide binding protein (G protein), beta polyp 59

438214 H06076 Hs 26320 TRABID protein 59

428046 AW812795 Hs 155381 "ESTs, Moderately similar to I38022 hypothetical protein [H 59

431941 AK000106 Hs 272227 "Homo sapiens cDNA FU20099 (is, clone COL04544" 59

403356 predicted exon 5 9

439031 AF075079 gb Homo sapiens full length insert cDNA YQ80A08 5 9

430032 AW936136 Hs 99610 ESTs 5 9

423457 F08208 Hs 155606 paired mesoderm homeo box 1 5 9

422158 L10343 Hs 112341 "protease inhibitor 3, skm-deraed (SKALP)" 59

406592 predicted exon 59

418636 AW749855 "gb QV4-BT0534-281299 053-C05 BT0534 Homo sapiens 58

429399 AA452244 Hs 16727 ESTs 58

408590 AW238162 Hs 253873 ESTs 58

422168 AA586894 Hs 112408 S100 calcium binding protein A7 (psonasin 1) 58

417421 AL138201 Hs 82120 "nuclear receptor subfamily 4, group A member 2" 58

401129 predicted exon 5 8

434745 AW974445 Hs 185155 "ESTs, Weakly similar to HuEMAP [H sapiens]" 5 8

402800 predicted exon 58

436185 AW753380 Hs 49753 "Homo sapiens mRNA for KIAA1561 protein, partial eds" 5 8

419519 AI198719 Hs 176376 ESTs 5 8

452542 AW812256 "gb RC0 ST0174-191099 031 a07 ST0174 Homo sapiens c 5 8

427166 AA431576 Hs 155658 ESTs 58

416168 H23687 gb yn72d12 Soares adult brain N2b5HB55Y Homo sapie 5 8

431467 N71831 Hs 256398 Homo sapiens mRNA, cDNA DKFZp434E0528 (from clon 58

421558 AB011125 Hs 105749 KIAA0553 protein 5 8

458055 AW979121 Hs 131375 "ESTs, Weakly similar to ALUB_HUMAN "" ALU CLAS 58

418345 AJ001696 Hs 241407 "serine (or cysteine) proteiπase inhibitor, clade B (ovalbumi 5 8

426544 AA492325 gb ng81b11 s1 NCI_CGAP_Pr6 Homo sapiens cDNA clone 58

433544 AI793211 Hs 165372 "ESTs, Moderately similar to ALU1_HUMAN ALU SUBF 58

442007 AA301116 Hs 142838 "Homo sapiens cDNA FLJ23444 fis, clone HSI01343" 58

443422 R10288 Hs 301529 ESTs 58

434311 BE543469 Hs 266263 "Homo sapiens cDNA FLJ14115 fis, clone MAMMA10017 5 8

424966 AU077312 Hs 153985 "solute earner family 7 (catiomc ammo acid transporter, y+ 5 8

441744 AA960922 Hs 200938 ESTs 5 8

413101 BE065215 "gb RC1-BT0314-310300 015-f01 BT0314 Homo sapiens c 57

445687 W80382 Hs 149297 ESTs 57

441369 AA931535 gb oo56a04 s1 NCl_CGAP_Lu5 Homo sapiens cDNA clon 57

414428 BE296906 Hs 182625 VAMP (vesicle associated membrane proteιn)-assocιated pr 57

431211 M86849 Hs 5566 "gap junction protein, beta 2, 26kD (connexin 26)" 57

411541 W03940 gb za62b02 ri Soares fetal liver spleen 1 NFLS Homo sapien 57

448612 AI696363 Hs 171285 ESTs 57

419118 AA234223 Hs 139204 ESTs 57

406322 predicted exon 57

454690 AW854639 "gb MR1-CT0258-140100-203-d10 CT0258 Homo sapiens 57

450313 AI038989 Hs 24809 hypothetical protein FU 10826 57

416292 AA179233 Hs 42390 nasopharyngeal carcinoma susceptibility protein 57

449309 AW589823 Hs 224189 ESTs 57

408418 AW963897 Hs 44743 KIAA1435 protein 57

416100 H18700 Hs 268799 ESTs 57

437845 AA769578 Hs 90488 ESTs 57

443345 AI052508 Hs 164482 "ESTs, Weakly similar to contains similaπty to TPR domain 57

418407 AL044818 Hs 84928 "nuclear transcπption factor Y, beta" 57

434557 AW855466 Hs 271866 "ESTs, Weakly similar to ALU1JHUMAN ALU SUBFAM 57

431688 AA513906 "gb ng67c08 s1 NCI_CGAP ϋp2 Homo sapiens cDNA clo 57

437641 AA811452 Hs 291911 ESTs 57

409319 AW752736 Hs 33565 ESTs 57

403967 AF030107 Hs 17165 regulator of G-protein signalling 13 57

445189 AI936450 Hs 147482 ESTs 57

414418 H62943 Hs 154188 ESTs 57

446563 BE326588 Hs 141454 ESTs 57

446075 AW451457 Hs 279179 ESTs 57

428068 AW016437 Hs 233462 ESTs 57 438425 AW292922 Hs 293170 ESTs 57

415532 R14780 Hs 12826 ESTs 57

441442 AL043282 Hs 131824 ESTs 57

443380 AI792478 Hs 135377 ESTs 57

445527 W39694 Hs 83286 ESTs 57

414376 BE393856 Hs 66915 "ESTs, Weakly similar to 167Kd protein [H sapiens]" 57

457960 AA771881 Hs 298149 ESTs 56

453293 AA382267 Hs 10653 ESTs 56

452503 AB000509 Hs 29736 TNF receptor-associated fxtor 5 56

405227 predicted exon 56

442257 AW503831 gb UI HF BN0 alb b-05-O-UI r1 N!H_MGC_50 Homo sap 56

403403 predicted exon 56

454377 AA076811 gb 7B03C12 Chromosome 7 Fetal Brain cDNA Library Horn 56

438656 H85310 Hs 209456 "ESTs, Weakly similar to NG22 [H sapiens]" 56

419936 AI792788 "gb Ol91d05 y5 NCI_CGAP_Kιd5 Homo sapiens cDNA clo 56

437267 AW511443 Hs 258110 ESTs 56

430563 AA481269 Hs 178381 ESTs 56

444835 AI198994 Hs 158479 ESTs 56

444902 AJ132099 Hs 12114 vanm 1 56

451800 AW977435 Hs 31890 ESTs 56

405465 predicted exon 56

403891 predicted exon 56

425557 AI694300 Hs 46730 ESTs 56

432162 AA584062 Hs 272798 hypothetical protein FU20413 56

450152 AI138635 Hs 22968 ESTs 56

410053 AW579707 Hs 59332 ESTs 56

421285 NM 000102 Hs 1363 "cytochrome P450, subfamily XVII (steroid 17-alpha-hydro 56

425264 AA353953 Hs 20369 'ESTs, Weakly similar to gonadotropin inducible transcript 56

418844 M62982 Hs 1200 arachidonate 12-lιpoxygenase 56

429616 AI982722 Hs 120845 ESTs 56

423528 AB011137 Hs 129740 KIAA0565 gene product 56

403089 predicted exon 56

414373 AW162907 Hs 75969 proline πch protein with nuclear targeting signal 56

403687 predicted exon 56

417079 U65590 Hs 81134 interleukin 1 receptor antagonist 55

432501 BE546532 Hs 287329 Fas binding protein 1 55

403691 predicted exon 55

409545 BE296182 "gb 601177324F1 NIH MGC 17 Homo sapiens cDNA clon 55

435990 AI015862 Hs 131793 ESTs 55

444409 AI792140 Hs 49265 ESTs 55

435478 AA682622 gb z]20f09 s1 Soares etalJιver_spleen_1NFLS_S1 Homo 55

439981 AI348408 Hs 124675 "ESTs, Weakly similar to unnamed protein product [H sapie 55

433644 AW342028 Hs 256112 ESTs 55

441541 AA938663 Hs 199828 ESTs 55

400709 predicted exon 55

407615 AW753085 "gb PM1-CT0247-151299 005 a03 CT0247 Homo sapiens 55

424153 AA451737 Hs 141496 MAGE like 2 55

452465 AA6 0211 Hs 34244 ESTs 55

406030 predicted exon 55

431071 AA491379 "gb aa65f05 r1 NCI_CGAP GCB1 Homo sapiens cDNA ci 55

418086 AA211791 Hs 269666 "Homo sapiens cDNA FLJ13415 fis, clone PLACE1001799 55

453034 BE246010 Hs 184109 nbosomal protein L37a 55

412953 Z45794 Hs 238809 ESTs 55

425351 AI206234 Hs 155924 cAMP responsive element modulator 55

406149 predicted exon 55

416533 BE244053 Hs 79362 retinoblastoma like 2 (p130) 55

458378 AI040535 Hs 150524 ESTs 55

401213 predicted exon 55

405904 predicted exon 55

445132 Z44811 gb HSC29G031 normalized infant brain cDNA Homo sapie 55

405138 predicted exon 55

442238 AW135374 Hs 270949 ESTs 55

416852 AF283776 Hs 80285 Homo sapiens mRNA cDNA DKFZp586C1723 (from clon 55

448691 AA481119 Hs 283558 hypothetical protein PR01855 55

452242 R50956 Hs 59503 ^■ESTs Weakly similar to AF157318 1 AD-017 protein [H s 55

456994 AA383623 Hs 293616 ESTs 55

440913 AI267491 Hs 160593 ESTs 55

435380 AA679001 Hs 192221 ESTs 55

450375 AA009647 Hs 8850 a dismtegnn and metalloprotemase domain 12 (meltπn alph 55

414035 Y00630 Hs 75716 "seπne (orcysteine) protemase inhibitor, clade B (ovalbumi 54

459084 H01699 Hs 27289 CGI-125 protein 54

405867 predicted exon 54

414093 BE544867 ^■gb 601078872F1 N!H MGC 12 Homo sapiens cDNA clon 54

447306 AI373163 Hs 170333 ESTs 54

413083 BE064528 "gb RC4-BT0311-250200 014-h06 BT0311 Homo sapiens 54

404828 predicted exon 54

402543 predicted exon 54

421988 AW450481 Hs 161333 ESTs 54

413404 BE503463 Hs 297431 ESTs 54

459043 AI806444 Hs 208113 "ESTs, Weakly similarto N-WASP [H sapiens]" 54

404410 predicted exon 54

430264 AA470519 "gb nc71f10 s1 NCI_CGAP_Pr1 Homo sapiens cDNA clon 54

431499 NM_001514 Hs 258561 general transcπpton factor UB 54

412566 AW962574 "gb EST374647 MAGE resequences, MAGG Homo sapien 54 454239 BE176420 Hs 8177 ESTs 54

458163 AA884304 Hs 131163 ESTs 54

446205 AW172662 Hs 149479 ESTs 54

455275 AW977806 "gb EST389810 MAGE resequences, MAGO Homo sapien 54

415579 AA165232 Hs 222069 ESTs 54

423200 AA323073 Hs 289083 ESTs 54

440052 AI633744 Hs 195648 ESTs 54

424717 H03754 Hs 152213 "wingless-type MMTV integration site family, member 5A" 54

420111 AA255652 gb zs21h11 ri NCI_CGAP_GCB1 Homo sapiens cDNA clo 54

432140 AK000404 Hs 272688 hypothetical protein FLJ20397 54

414904 AA157881 Hs 143056 ESTs 54

409479 BE163800 Hs 136912 ESTs 54

404727 predicted exon 54

446011 AI623778 Hs 145809 ESTs 54

456083 U46922 Hs 77252 fragile histidine tπad gene 54

424834 AK001432 Hs 153408 "Homo sapiens cDNA FU10570 fis, clone NT2RP2003117 54

425071 NM 013989 Hs 154424 "deiodinase, lodothyronme, type II" 54

426065 N32049 gb yw96g08 s1 Soares placenta 8to9weeks 2NbHP8to9W 54

415602 F12920 Hs 165575 ESTs 54

432839 AA579465 Hs 287332 ESTs 54

416879 H98899 Hs 42599 ESTs 54

456088 BE177320 Hs 156148 "Homo sapiens cDNA FU23082 fis, clone LNG06451" 54

423175 W27595 Hs 18653 ESTs 54

424585 AA464840 gb zx43h11 r1 Soares Jotal_fetus_Nb2HF8_9w Homo sapie 53

452281 T93500 Hs 28792 "Homo sapiens cDNA FLJ11041 fis, clone PLACE1004405 53

424323 AA338791 Hs 146763 nascent-polypeptide-associated complex alpha polypeptide 53

426701 AI968103 Hs 209461 "Homo sapiens cDNA FLJ12836 fis, clone NT2RP2003206 53

447645 AW897321 Hs 159699 ESTs 53

402974 predicted exon 53

436607 AW661783 Hs 211061 ESTs 53

428873 AI701609 Hs 98908 ESTs 53

405454 predicted exon 53

431867 AA523660 Hs 191727 ESTs 53

442768 AL048534 Hs 48458 "ESTs, Weakly similar to ALU8_HUMAN ALU SUBFAM 53

424085 NM 002914 Hs 139226 replication factor C (activator 1) 2 (40kD) 53

435098 AF174394 Hs 177461 "Homo sapiens apoptotic-related protein PCAR mRNA, par 53

421284 U62435 Hs 103128 "chohnergic receptor, nicotinic, alpha polypeptide 6" 53

435711 AF226667 Hs 58553 CTP syπthase II 53

405292 predicted exon 53

410123 T16981 Hs 21963 ESTs 53

435435 T89473 Hs 192328 ESTs 53

417071 N58820 Hs 275133 ESTs 53

438958 H50167 Hs 33113 ESTs 53

457405 AA504860 gb ab03a10 si Stratagene fetal retina 937202 Homo sapiens 53

413642 BE154837 "gb PM1-HT0345-121199 001-C08 HT0345 Homo sapiens 53

433868 AA612960 gb nq38g06 s1 NCI CGAP Co10 Homo sapiens cDNA clo 53

444461 R53734 Hs 25978 ESTs 53

427088 AA398085 Hs 142390 ESTs 53

451307 AW293207 Hs 211516 ESTs 53

403831 predicted exon 53

402892 predicted exon 53

433420 AI674093 Hs 293961 ESTs 53

455759 BE080469 "gb QV1-BT0630-280200-086 d06 BT0630 Homo sapiens 53

411379 AI816344 Hs 12554 "ESTs, Weakly similar to Nucleosome Assembly Protein 1- 53

428483 AI908539 Hs 184592 KIAA0344 gene product 53

429208 AA447990 Hs 190478 ESTs 53

447572 AI631546 Hs 159732 ESTs 53

434896 AW022054 Hs 136591 ESTs 53

417616 R07728 Hs 268668 ESTs 53

411805 AW864183 "gb PM0-SN0014-260400-002-d02 SN0014 Homo sapiens 53

419000 T79855 Hs 268592 ESTs 53

413488 BE144017 Hs 184693 "transcription elongation factor B (Sill), polypeptide 1 (15k 53

400975 predicted exon 53

407453 AJ132087 gb Homo sapiens mRNA for axone al dyneiπ heavy chain ( 53

430757 AI458623 "gb tk04g09 x1 NCI_CGAP_Lu24 Homo sapiens cDNA clo 53

417793 AW405434 Hs 82575 small nuclear nbonucleoprotein polypeptide B' 52

401877 AB011094 Hs 129892 KIAA0522 protein 52

457122 AI026157 Hs 33728 "ESTs, Weakly similar to ALU1 HUMAN ALU SUBFAM 52

410706 AI732404 Hs 68846 ESTs 52

435807 AI033299 Hs 113614 ESTs 52

428398 AI249368 Hs 98558 ESTs 52

401088 predicted exon 52

414501 N43991 Hs 171984 ESTs 52

419083 AI479560 Hs 98613 "Homo sapiens cDNA FU12292 fis, clone MAMMA10018 52

421107 AA283822 Hs 55606 "ESTs, Weakly similar to ZN91 HUMAN ZINC FINGER P 52

411489 AW848346 "gb IL3-CT0214-150200-076 F03 CT0214 Homo sapiens c 52

419249 X14767 Hs 89768 "gamma-aminobutyπc acid (GABA) A receptor, beta 1" 52

430082 AW514083 Hs 190135 ESTs 52

425698 NM 016112 Hs 159241 polycystic kidney disease 2-lιke 1 52

451686 AA059246 Hs 110293 ESTs 52

453867 A1929383 Hs 108196 HSPC037 protein 52

419985 H66373 Hs 15973 "ESTs, Highly similar to bA393J16 3 [H sapiens]" 52

426650 AA382814 "gb EST96097 Testis I Homo sapiens cDNA 5' end, mRNA 52

424115 AA335497 Hs 293965 ESTs 52 405576 predicted exon 52

409584 AA076010 gb zm89f12 s1 Stratagene ovanan cancer (937219) Homo sa 52

454423 AW603985 Hs 179662 nucleosome assembly protein 1-lιke 1 52

417173 U61397 Hs 81424 ubiquitin-like 1 (sentπn) 52

439155 H81076 Hs 269001 ESTs 52

432267 AK000872 Hs 274227 "Homo sapiens cDNA FU10010 fis, clone HEMBA100030 52

459024 AA020799 Hs 179825 RAN binding protein 2-lιke 1 52

404088 predicted exon 52

403525 predicted exon 52

445882 AI948717 Hs 225155 "ESTs, Weakly similar to PSF_HUMAN PTB-ASSOCIATE 52

448257 AW772070 Hs 253146 ESTs 52

410500 R09442 gb yf26c09 r1 Soares fetal liver spleen 1 NFLS Homo sapien 52

456084 AA155859 Hs 79708 ESTs 52

410523 BE143839 "gb MR0-HT0164-151299 012-d03 HT0164 Homo sapiens 52

434623 AB023163 Hs 4014 KIAA0946 protein, Huntingtin interacting protein H 52

454484 AW795196 Hs 215857 ππg finger protein 14 52

402131 predicted exon 52

438913 AI380429 Hs 172445 ESTs 52

402628 predicted exon 5 1

415973 R24707 Hs 260201 ESTs 51

455640 BE064059 "gb QV3-BT0296-010300-111-e04 BT0296 Homo sapiens 5 1

442750 AI016803 Hs 131096 ESTs 51

404638 predicted exon 5 1

431117 AF003522 Hs 250500 delta (Drosophιla)-lιke 1 51

428819 AL135623 Hs 193914 KIAA0575 gene product 51

439519 AA837118 Hs 118366 ESTs 5 1

427335 AA448542 Hs 251677 G antigen 7B 5 1

416450 AA18Q467 Hs 142556 ESTs 51

440876 AW613524 Hs 279570 ESTs 5 1

414584 BE409585 "gb 601301836F1 NlH_MGC_21 Homo sapiens cDNA clon 5 1

443175 N57863 gb yv60c02 s1 Soares fetal liver spleen 1 NFLS Homo sapie 51

408968 AI652236 Hs 49376 hypothetical protein FLJ20644 51

415654 AW968363 "gb EST380439 MAGE resequences, MAGJ Homo sapiens 5 1

440559 AW629054 Hs 125976 "ESTs, Weakly similar to metalloprotease/disintegπn/cystei 51

421236 AI287622 Hs 151956 ESTs 51

416258 N45661 Hs 275131 ESTs 51

405982 predicted exon 5 1

406589 predicted exon 5 1

412458 AW953229 Hs 169142 ESTs 5 1

435693 AI033134 Hs 119887 ESTs 5 1

449182 AW292381 Hs 224150 ESTs 5 1

403963 predicted exon 5 1

440830 AI733112 Hs 176101 ESTs 51

415412 F08049 Hs 52132 ESTs 51

442832 AW206560 Hs 253569 ESTs 5 1

445359 AI808725 Hs 147783 ESTs 5 1

412088 AI689496 Hs 108932 ESTs 5 1

428785 A1015953 Hs 125265 ESTs 51

430163 X66610 Hs 234748 "enolase alpha, lung specific" 51

455441 AW945964 "gb QVO-ET0001-050500-228 e09 ET0001 Homo sapiens c 5 1

400304 AF005082 Hs 113261 "Homo sapiens skin-specific protein (xp33) mRNA, partial 5 1

403944 predicted exon 5 1

457069 BE159191 Hs 114318 "ESTs, Weakly similar to ORF1 [H sapiens]" 5 1

414125 BE253197 "gb 601116804F1 NIH MGCJ6 Homo sapiens cDNA clon 5 1

448566 AW291319 Hs 194574 ESTs 51

457948 AI498640 Hs 159354 ESTs 51

438240 N92638 Hs 124004 ESTs 51

404070 predicted exon 5 1

402709 predicted exon 51

416425 BE077308 "gb RC1-BT0606-060200-012 h12 BT0606 Homo sapiens 50

407173 T64349 gb yc10d08 s1 Stratagene lung (937210) Homo sapiens cDN 50

452502 AI904296 "gb PM-BT046-220199 286 1 BT046 Homo sapiens cDNA 50

446657 AI335191 Hs 260702 "ESTs, Moderately similar to ALU7 HUMAN ALU SUBF 50

459124 AW301478 Hs 299178 ESTs 50

409940 BE548143 "gb 601073109F1 NIH_MGC_12 Homo sapiens cDNA clon 50

443547 AW271273 Hs 23767 "Homo sapiens cDNA FU12666 fis, clone NT2RM400225 50

447452 BE618258 Hs 102480 ESTs 50

414327 BE408145 Hs 185254 "ESTs, Moderately similar to NAC- protein [R norvegicus] 50

416155 AI807264 Hs 205442 "ESTs, Weakly similar to AF117610 1 inner centromere pro 50

408081 AW451597 Hs 167409 ESTs 50

426834 AI091533 Hs 135167 ESTs 50

433368 AW877277 "gb MR4-PT0051-150200-001-d03 PT0051 Homo sapiens 50

433098 AW190593 Hs 151143 ESTs 50

439721 W92142 Hs 271963 "ESTs, Weakly similar to ALU5_HUMAN ALU SUBFAM 50

441818 AI630451 Hs 7976 KIAA0332 protein 50

458804 AL157625 gb DKFZp761L2016_ 761 (synonym hamy2) Homo sapi 50

411905 BE265067 "gb 601193893F1 NIH_MGC_7 Homo sapiens cDNA clone 50

434248 AA628151 Hs 187783 ESTs 50

423967 AW296756 Hs 11641 "Homo sapiens cDNA FU21432 fis, clone COL04219" 50

456212 N51636 gb yy87b01 s1 Soares_multιple_sclerosιs_2NbHMSP Homo 50

442914 AW188551 Hs 99519 "Homo sapiens cDNA FLJ14007 fis, clone Y79AA1002407 50

436084 AK000185 "gb Homo sapiens cDNA FU20178 fis, clone COL09990" 50

449252 AW594482 Hs 253315 ESTs 50

454653 AW812227 "gb RC2-ST0173-201099-011 -g09 ST0173 Homo sapiens c 50 414699 A1815523 Hs.76930 "synuclein, alpha (non A4 component of amyloid precursor) 5.0

443335 T89697 Hs.16645 ESTs 5.0

448419 AL080072 Hs.21195 Homo sapiens mRNA; cDNA DKFZp564M0616 (from clon 5.0

425574 AA359663 "gb:EST68717 Fetal lung II Homo sapiens cDNA 5' end, mR 5.0

435174 AA687378 Hs.194624 ESTs 5.0

429548 AW138872 Hs.135288 ESTs 5.0

450613 AI702055 "gb:tq20g10.x1 NCI_CGAP_Ut1 Homo sapiens cDNA clon 5.0

400432 AX015809 Hs.287767 Sequence 8 from Patent WO9950285 5.0

421751 AW813731 Hs.159153 ESTs 5.0

405800 predicted exon 5.0

429430 AI381837 Hs.155335 ESTs 5.0

439518 W76326 gb:zd60d04.r1 Soares_fetal_heart_NbHH19W Homo sapien 5.0

430884 AF053748 Hs.248114 glial cell derived neurotrophic factor 5.0

452741 BE392914 Hs.30503 "Homo sapiens cDNA FLJ11344 fis, clone PLACE1010870 5.0

441001 AW137017 Hs.126373 Human DNA sequence from clone RP5-1184F4 on chromos 5.0

438490 AW593272 Hs.26261 ESTs 5.0

408170 AW204516 Hs.31835 ESTs 5.0

449104 R08702 gb:yf24c06.r1 Soares fetal liver spleen 1 NFLS Homo sapien 5.0

TABLE 1B:

Pkey: Unique Eos probeset identifier number CAT number: Gene cluster number Accession: Geπbank accession numbers

Pkey CAT Number

407615 10054041 AW753085 AW753082 AW054744 AW753107 AW753087

408391 10556871 AW859276 AW859274 AW190959 T91463

408523 10639251 AW833259 AW833273 AW206846

408914 1089828 -1 AW450309

408987 1093061 ' H85615 H86300 H86263 H86282 AA059278 H86304

409191 11071761 AW818390 AW818237 AW858911 AW858977 BE072544 W26498

409545 11388231 BE296182 AW629821

409584 1141651 AA076010 AA076009 AI094314

409695 1148761 AA296961 AA296889 AA076945 AA077528 AA077497

409866 11565221 AW502152 H41202 H29772

409867 11565301 AW502161 AW502587AW502345

409940 11609941 BE548143 AW511659

409982 11650221 BE005839 BE005619 AW516815

410500 12063231 R09442 AW846115 AW846108 AW751967 AW846083 AW846087 AW846090

410523 12070411 BE143839 AW752787 AW752795 BE143584 N71805

410536 12073221 N39533 AW753094AW753093

410626 1212621 -1 BE407727

410966 12280711 AW812088 AW812105 AW812082

411004 12289751 AW813242 BE146089 AW813195 AW813173 AW813206 BE145953 BE146212 AW813196 AW854582 AW813241 BE061582

411018 12291321 AW813428 AW813444 AW813367 AW813368 AW813429 AW813424

411057 12304931 AW815098 BE154843 BE154831

411178 1234752.1 AW820852 AW820773 AW821088

411237 1236377 AW833676 AW833814 AW833798 AW833677 AW833449 AW833630 AW833626 AW833444 AW833366 AW833791 AW833659 AW833432 AW833534 AW833556 AW833553

411483 1247172.1 AW848115 AW848127 AW887028 AW887117

411489 12473601 AW848346 AW848760 AW848340 AW848818 AW849043 AW849061

411541 12490441 W03940 T98335 AW850705

411660 12530781 AW855718 AW855740 AW855748

411693 12542061 AW857271 AW857308 AW857296 AW857258

411722 12549141 AW875942 AW858234 AW875938 AW875941 AW858235 AW875958

411725 1255047J AW858396 AW858505 AW858476 AW861971 AW858556 AW861908 AW858514 AW858601 AW861909 AW858434 AW858400 AW858405 AW858393

411748 12561781 AW859920 BE079582 AW997112

411805 12592731 AW864183 AW864181 AW864135AW864198

411905 12651811 BE265067 BE264978 AW875420

411940 1266262.1 AW876686 AW876717 AW877215 AW876691 AW876722 AW877218 AW876694 AW876725

412167 12806051 AW897230 AW897252 AW897244 AW897231 AW897263

412333 12890371 AW937485 AW937589 AW937658 AW937654 AW937492

412402 1292917.1 AW984788 AW984816 AW984811 AW984807 AW984819 AW984790 AW984782 AW984784 AW984780 AW984814 AW984795 AW984793 AW984789 AW984823 AW948021 AW984802 AW984800 AW984799 AW984825 AW984792 AW984821 AW984820 AW984808 AW984809 AW984812 AW984801 AW984813 AW984778 AW984804 AW984798 AW948017 AW984827

412566 13064691 AW962574 BE073261

412670 1319901 AA115456 AW978117 AA814593

412740 13245381 AW993984 AW994001 AW994002

412761 13254241 AW995092 AW995095 AW995103

413083 13486391 BE064528 BE064589 BE064561

413101 13491541 BE065215 BE155544 BE155541 BE155540 BE155542 BE155543

413252 13558771 BE074910 BE074913 BE074911 BE074903 BE074892 BE074935

413382 13659541 BE090689 BE090685 BE090697 BE090680 BE090691 BE090696 BE090698 BE090686

413425 1368851 F20956 AA129374 AA133740 AW819878

413470 13716001 N20934 BE141875 BE141877

413521 13746121 BE145814 BE145830 BE145884 BE145823 BE145905 BE145883 BE145833 BE145889 BE145834

413544 13756711 BE147225 BE147205 BE147234

413642 13813861 BE154837 BE154879 BE154850 BE154877 BE154835 BE154849 BE154902 BE154905 BE154867 BE154901 BE154904 BE154899

413702 13838991 BE170313 BE158339 BE158290

413864 13957881 BE175582 BE175514 BE175505 BE175591 BE175530

414093 1416417.1 BE544867 BE247720

414125 14192301 BE253197 BE259456 BE254462

414195 1424854 -3 BE263293 414210 14260511 BE383592 BE261671

414266 14309841 BE267834 BE514180 BE514096

414315 1435121 Z24878 AA494098 F13654 AA494040 AA143127

414539 14603201 BE379046 BE395459

414540 1460324 -1 BE379050

414584 1464068 -1 BE409585

414605 1465790 -1 BE390440

414606 1465801.1 BE387771 BE387954 BE389705

414808 14926241 T95945 R98276 BE539541

414954 15098571 D81402 C15494 D61078 D61313 D80399 D81520

414995 15117361 C18200 D78681 T82025

415613 15406021 R20233 F12901 T74740

415654 154135.1 AW968363 AA465492 R34539 AA165411

415715 15488181 F30364 F36559 T15435

415747 1551891 AA381209 AA381245 AA167683

416151 15739261 T26661 Z44135 H23016

416168 15745451 H23687 H46460 H40239

416425 1593881 BE077308 AL043350 AW962170 AA180251 AA325287

416441 1594801 BE407197AA182474 AA180369 BE275628 BE276131

416548 16001811 H62953 N76608 N72413

416665 1607797.1 H72974W28967

416913 163001.1 AW934714 BE161007 BE162500 AW749902 AW749864 BE162498 BE161005 AA190449 AW513465 BE161006 BE162499

417344 1668271 AW997313 AA195805

417549 1687001 AA203651 R89136

417611 1689001 AW993983 AW994798 AW993990 AW993999 AW993989 AA204755

417682 16927591 W69561 R08486 R87183^"

418636 1774021 AW749855 AA225995 AW750208 AW750206

418709 178363.1 AA227394 AA641866 AW750732

419753 1877631 N42531 W25700AA249574AA569553

419936 189181.1 AI792788 BE142230 AA252019

420111 1907551 AA255652 AA280911 AW967920 AA262684

422949 2231841 AA319435 N56456 AA319377 AW961532 T48452 AA894424

423735 2314981 AA330259 AA661806 AA502431 AW974633 AA649496

423756 2317251 AA828125 AA834883 AA330555

423843 2325101 AA332652 AA331633 AW999369 AW902993 BE170475 AA378845 AW964175 AI475221

424101 2353981 AA335394 AA335535 AA335244 AW966148

424324 2381271 AA346316 BE160193 AA338802 AW954536

424585 2411511 AA464840 AA343628

424872 2445051 AA347923 AA347928 AW961769

425090 2466491 AA350552 R21667 AW953258

425574 2533171 AA359663 AA359654 AW963124

425612 2539691 BE004257 AW811190 AA360576 BE172402 BE181703

426065 2602761 N32049 R34821 R78237

426130 2614141 AA853282 BE255688 AA370481

426544 2689871 AA492325 AA503675 AA381181

426650 2702831 AA382814 AA402411 AA412355

429163 3005431 AA884766 AW974271 AA592975 AA447312

430264 3150081 AA470519 BE303010 BE302954 BE384120

430757 3229471 AI458623 AA639708 AA485409 R22065 AA485570

431071 3275501 AA491379 H86020 AW969148

431688 3366091 AA513906 AA847734 AI357044

431822 3380821 AA516049 AW004922

432189 3428191 AA527941 AI810608 AI620190 AA635266

432340 3452481 AA534222 AA632632 T81234

432363 3454691 AA534489 AW970240 AW970323

432966 3568391 AA650114 AW974148 AA572946

433368 3642761 AW877277AW811294

433449 3665321 AW772282 AA592974

433868 3756291 AA612960 AI934769 T12348

434098 3800061 AA625499 AA625269 AA625184

434374 3848891 AA631439 A1086355 AI082577

434804 3934811 AA649530 AA659316 H64973

434950 3960611 AW974892 AA654375

435478 4066831 AA682622 BE141696

436084 414371 AK000185 AW841262

436532 4218021 AA721522 AW975443 T93070

436843 4277481 AA824588 AA732269 AW977146

437096 4330061 AA744406 AA745347 AA745535

437146 43371.1 AA730977 AI261584 AA334473 Z43283 AW875861 AW938044 BE150701 AW936262 AA306862 BE565575 BE567380 AA728920 AA167612

AI239729 AI251752 AA485791 BE568425 AW962958

437152 433861 AL050027 BE089051

437229 4349471 AW976005 AW419264 AA747275 AA810377

439031 467981 AF075079 H48601 H48795

439152 469201 H6501 AF086007 H65015

439518 473341 W76326AF086341 W72300

440051 484262 BE559980 BE397203 BE268207 BE559764 BE267725 BE513654 BE267742 BE268219 BE267665 BE561356

441194 511931 BE274581 BE275382AA703515 BE166690

441369 5156361 AA931535 AI458601 Z44913

442257 536991 AW503831 AW503317 BE565665

443161 5613051 AI038316AI344631 AI261653

443175 5618821 N57863 AI038952 W90167 N64103

443198 5626551 A1039813AI684642 Z40121 AI951414 BE501049

443534 572957.1 AI076123 A!244834 AI695239

443613 575391.1 AI079356 W23287 443657 576685.1 R14973 R14967 AI081006

443747 57918.1 AV646352 AV652121 AV652008

443860 583216.1 A 866632 A1089351 D61942

445132 63111.1 Z44811 R13709 AV652749 AW814906 AA084016

445153 631644.1 AI214671 Z45244 H24136 R25934

445232 6334331 BE294357 N36568 AI217006

446171 664826.1 AI374927 AI278380 A1301383

447252 7141601 R90916 AL120023 R18429 Z42095 A1369730 R90824

448516 766241.1 AW898595 AW898588 AW898590 AW898663 AW898592 AI525093

4 44499110044 7 79988114499.11 R08702 R09864 AI630313

450613 840016.1 AI702055 R89204 R86260

452077 897051.1 BE144949 BE144991 BE144990AI832199

452502 919733.1 AI904296 BE007223 R30687

452507 9 „1.9_9.,9.,8-_1. A1904646 BE179494 BE179421

4 45522554422 9 92211441100..11 AW812256 AW812257 AI906423 AI906422

452563 9222651 AI907552 C03707 C02870

452947 939810.1 AW130413 AI932362

453509 9696321 AL040021 AL040037

453845 9830.27,_--1, AL157568

4 45544118822 1 1004499556699.11 AW177335 AW177352 AW177340 AW177378 AW177339 AW177388 AW177393

454377 1147611 AA076811 AW814764

454389 115682.1 AW752571 AW847602AA077979

454455 12069651 AW752710 BE180336 BE180186

454505 1219564.1 AW801365 AW801435 AW801372

4 45544555566 1 1222233887788..11 AW807073 AW807055 AW807067 AW807276 AW807030 AW807363 AW845892 AW807091 AW807275 AW807284 AW807287 AW845891

AW807195 AW807271 ^'

454574 1225636.1 AW809109 AW809112 AW809122 AW809126 AW809128 AW809133 AW809131 AW809113 AW809111 AW809132

454597 1226059.1 AW809648 AW809704 AW809643 AW809653 AW809709 AW809949 AW809939 AW810010 AW809705 AW809950 AW809822 AW809667

AW810093 AW810076 AW809673 AW810349 AW809895

4 45544663333 1 1222277550044.11 AW811380 AW811385

454653 1228081 1 AW812227 AW812294 AW812092

454690 12291061 AW854639 AW854719 AW854718 BE145880 AW854692 BE145866 AW816154 AW854698 AW854654 AW813335 AW854699

454707 1230250J AW814989 AW814852 AW814808

454822 12363691 AW833793 AW833799 AW833346 AW833371 AW833795 AW833562 AW833667 AW833377

4 45544887744 1 1223388449944.11 AW836407 BE175600 BE175579

454913 12422381 AW841462 BE156657 BE156668 BE092475

454934 1245577.1 AW846080 AW846074 AW846118 AW846130

454963 1246752.1 AW847647 AW847659 AW847656 AW847653 AW847717 AW847786

455013 12488991 BE073250 BE073378 BE073379 AW850533 AW850529

4 45555009922 1 12255229977111 BE152428 AW855572 AW855607

455110 1253955J BE154505 BE154462 BE154454 BE154460 BE154489 BE154496 AW856909 BE154497 BE154565 BE154572 BE154500 BE154472

455121 12543391 BE156459 BE156469 BE156468 AW857447

455152 12552271 AW858621 AW937120

455203 12599731 AW865450 AW865119 AW865452 AW865461 AW865325 AW865114 AW865116 AW865321 AW865590 AW865390

4 45555227755 1 1227722225555..11 AW977806 AW887923 AW886321

455435 12905461 AW939445 AW939465 AW939604 AW939531 AW939530 AW939993

455441 1291505.1 AW945964 AW946020 AW946034 AW946027 AW946041 AW946044 AW946033 AW946024 AW946021 AW946029 AW946015 AW946016

AW946039 AW946045 AW946028 AW946036

455592 13351961 BE008002 BE007997 BE007998 BE008000

4 45555664400 1 1334488114411.11 BE064059 BE063903 BE063838 BE063863 BE064056 BE063974 BE063904 BE063898 BE063896 BE063906 BE063980

455662 13492061 BE065387 BE065310 BE065391

455713 1352512.1 BE069891 BE158893 BE069898 BE158900

455759 13593161 BE080469 BE080474 BE080477 BE080546 BE080545

455851 1375451 1 BE146879 BE146914 BE146918

4 45555885533 1 1337755667711.11 BE147225 BE147205 BE147234

455879 1380017.1 BE153275 BE153189 BE153329 BE153022 BE153030 BE152974

455993 13986651 BE179085 BE179084 BE179086 BE179264

456072 14702561 H54381 H54463 BE393262

456101 151654.1 AA159478 AW901089 AA160437AW593155

4 45566221122 1 1665555556655.11 N51636T51874T51829

456309 1770261 AA225423 AA225369 BE144153 AW801549

456714 221500.1 AW897265 AW897274 AL119504 AW897275 AW897270 AW897312 AW897318 AW897317 AA317240 AW961361 T06241 AA326794

AL138130 AW407975 AW999277

457405 333127.1 AA504860 AA504911

4 45577662200 3 37711551144J1 AA602711 BE078290

457727 3935661 AW974687 AA649656 AA652145

457868 4260951 AW975133 AA729943 AA805813

458154 491768.1 AW816379 AA888282 AA879046 AA879195

458804 758031 AL157625 N72696 BE622492 4 45588882299 7 7 7777333444444333..111 AI557388 BE158936

458841 7841861 W28965 W28971

459160 9200511 AI904723 AI904725 AI904729 AI904722 AI904758 AI904736

459170 9206461 AI905518 AI905516 AI905457 AI905515 AW176013 AW176037

459186 9228881 AI908287 BE064074 BE068820 BE068823 BE068822 BE068826

TABLE 1C:

Pkey: Unique number corresponding to an Eos probeset

Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (Gl) numbers. "Dunham I. et al." refers to the publication entitled The DNA sequence of human chromosome 22" Dunham, et al. (1999) Nature 402:489495 Strand: Indicates DNA strand from which exons were predicted N position: Indicates nucleotide positions of predicted exons Pkey Ref Strand NLposition

400584 9887612 Minus 18398-18573

400593 9887642 Minus 25013-25127

400612 9929646 Minus 151513-151662

400613 9864507 Plus 92278-92472

400623 7228177 Plus 74195-74335,74653-74827

400709 7249204 Plus 153075-154680

400749 7331445 Minus 9162-9293

400842 1927148 Plus 90462-90673

400925 7651921 Plus 38183-38391,43900-44086

400964 7139719 Minus 155282-155403

400968 7923967 Plus 19938-20043

400975 7139779 Minus 108473-108847

400983 8081198 Plus 107903-108832

401032 8117525 Minus 68451-68555

401050 8117628 Minus 78449-79425

401088 8492704 Plus 194659-195179

401129 8699792 Minus 62022-62242,62326-62451,62543-62710,63072-63167

401200 9743387 Minus 111586-111806,114791-114916,115419-115583,116351-116446,116847-116907,122853-123067,124982-125407

401213 9858408 Plus 98243-98380,98489-98619

401230 9929527 Minus 33835-34006,34539-34592,36461-36745,48925-49098,52604-52758

401245 4827300 Minus 59373-59531

401260 8076883 Minus 86008-86355

401269 8954206 Plus 2259-2591

401283 9800093 Minus 47256-47456 ,

401497 7381770 Plus 92607-92813

401508 7534110 Minus 110779-110983

401521 7705251 Plus 9127-9234

401530 7770649 Plus 41468-42406

401575 7229804 Minus 76253-76364

401604 7689963 Minus 119835-120185

401780 7249190 Minus 28397-28617,28920-29045,29135-29296,29411-29567,29705-29787,30224-30573

401781 7249190 Minus 83215-83435,83531-83656,83740-83901,84237-84393,84955-85037,86290-86814

401793 7263888 Minus 102945-103083

401809 7342191 Minus 107548-108298

401862 7770606 Minus 55839-55993,59145-59293

401881 8122429 Minus 148470-148651,153418-153618,154282-154438

402018 7528100 Plus 168728-168859

402046 8072415 Plus 166394-166556,168167-168395

402050 8076908 Minus 130105-130227

402071 8117361 Plus 85924-86039

402075 8117407 Plus 121907-122035,122804-122921,124019-124161,124455-124610,125672-126076

402131 7704961 Minus 33114-33209,33496-33678

402203 8576119 Minus 8124-8285

402222 9958106 Plus 3261-3834,3939-4269

402296 6598824 Plus 22587-23723

402298 6598824 Plus 36758-37953

402421 9796341 Minus 46609-46662,46758-46811,86293-86346,89776-89829,90048-90101,102817-102924

402425 9796347 Minus 50224-50395

402481 9797406 Plus 87891-88991

402529 7630937 Minus 165-917

402543 9838066 Minus 89684-90893

402576 7230225 Minus 1867-2247

402578 9884928 Plus 66350-66496

402628 9931216 Plus 31753-31966

402631 9931231 Minus 115658-116580

402639 9958129 Minus 20167-22383

402664 8077024 Plus 70318-70846

402709 8901246 Minus 56847-57055

402738 7331557 Minus 8725-8859

402745 9212200 Minus 76516-76690

402790 4835258 Minus 147744-147861

402794 6136940 Minus 131034-131794

402800 6010175 Plus 43921-44049,46181-46273

402859 9588237 Minus 69821-75323

402892 8086844 Minus 194384-194645

402974 9663349 Plus 124035-124321

403041 3171152 Plus 70527-71019

403065 8954197 Minus 71615-71773,73930-74144

403083 8954241 Plus 163070-163351

403089 8954241 Plus 171964-172239

403093 8954241 Plus 177083-177373,177464-177751

403177 9838213 Minus 142560-142726

403273 8018055 Plus 133809-134099

403334 8568877 Minus 137205-137350

403350 8569775 Minus 135374-135523

403356 8569930 Plus 92839-93036

403403 9438460 Plus 21240-21399

403525 7960440 Plus 152431-153243

403568 8101145 Minus 85509-85658

403647 8699843 Minus 35849-36204

403687 7387384 Plus 9009-9534

403691 7387384 Minus 88280-88463

403698 4263532 Plus 10464-10907 403741 7630932 Minus 2833-3468

403747 7658395 Minus 20493-20621

403786 8083636 Minus 73028-73217

403831 7249249 Minus 61468-61575

403891 7331467 Minus 191508-193220

403944 7711864 Minus 129213-129415

403963 8568150 Plus 149466-149665

404070 2996642 Plus 7210-7414,10043-10195

404088 9958257 Plus 184131-184295

404097 7770701 Plus 55512-55781

404166 7596822 Plus 86147-86509

404270 9828129 Minus 3649-3750,4161-4306,5962-6049,6849-6965

404340 7630856 Plus 10898-11506

404410 7342122 Plus 49052-49176,56177-56273,59384-59488

404599 8705107 Plus 110443-110733

404638 9796751 Minus 99433-99528,100035-100161

404664 9797142 Minus 104257-105215

404727 8081050 Plus 115534-115747

404767 7882827 Minus 23244-23759

404828 6580415 Minus 26291-27253

404849 7706886 Plus 144843-144964,149846-150121

404893 6850447 Plus 65083-65223

404898 7331420 Minus 177015-177328

404952 7382669 Minus 136326-136618

404972 3213020 Plus 48711-49524.

404992 4662677 Minus 106104-106199,111659-111781

405071 7708797 Minus 11115-11552

405138 8576241 Plus 90303-90516

405196 7230083 Minus 135716-135851

405227 6731245 Minus 22550-22802

405277 3980473 Plus 23471-23572

405285 6139075 Minus 55744-55903,57080-57170,61478-61560

405292 3845420 Plus 33227-33442

405336 6094635 Plus 33267-33563

405362 2337862 Minus 105008-105142,105980-106091,140445-140556,142519-142641

405382 6552767 Plus 31923-32311

405454 7656675 Plus 133807-134053

405465 7767904 Plus 8935-9073,12242-12367,13364-13506,14965-15493

405472 8439781 Plus 106297-106447,108462-108596

405547 1054740 Plus 124361-124520,124914-125050

405576 4003382 Plus 84000-85009

405621 5523811 Plus 59362-59607

405636 5123990 Plus 56384-56587

405675 4557087 Plus 70304-70630

405708 4156182 Plus 55030-55604

405771 7018349 Plus 91191-91254,91510-91589

405783 5738434 Minus 27238-27885

405793 1405887 Minus 89197-89453

405800 2791346 Plus 19271-19813

405810 4938307 Minus 64543-64966

405848 7651809 Minus 28135-28244

405851 6164995 Minus 26407-27151

405867 6758731 Minus 74553-75173

405896 6758795 Plus 57311-57874

405904 7705118 Minus 16375-16584

405917 7712162 Minus 106829-107213

405982 8247790 Minus 36028-36408

406030 8312328 Minus 96123-96547

406053 6758997 Plus 30921-31532

406057 6691254 Minus 20830-21222

406149 7144791 Minus 44464-45164

406163 7158901 Plus 66690-66835

406277 5686030 Minus 4759-5490

406322 9212102 Minus 130230-130418

406349 9256007 Minus 21251-21526

406504 7711360 Minus 107068-107277

406544 7711508 Plus 46576-46757

406589 8224211 Plus 38806-38989

406592 4567182 Plus 352560-352963

TABLE 2A lists about 187 genes up-regulated in ovanan cancer compared to normal adult tissues that are likely to be extracellular or cell-surface proteins These were selected as for Table 1 A, except that the ratio was greater than or equal to 25, and the predicted protein contained a PFAM domain that is indicative of extracellular localization (e g , ig, fn3, egf, 7tm domains)

TABLE 2A ABOUT 187 UP-REGULATED OVARIAN CANCER GENES ENCODING EXTRACELLULAR/CELL SURFACE PROTEINS

Pkey Pπmekey

Ex Accn Exemplar Accession

UG ID UniGeπe lD

Title Unigene Title

PFAM domains ratio tumor vs normal tissues Pkey Ex Accn No UG ID Title PFAM domain ratio

423017 AW178761 Hs 227948 seπne (or cysteine) prateinase inhibito serpm 636

431938 AA938471 Hs 115242 developmentally regulated GTP-bindi SCP 320

425650 NM 001944 Hs 1925 desmoglein 3 (pemphigus vulgaπs ant cadheπn 300

418994 AA296520 Hs 89546 selectin E (endothelial adhesion molec EGFJectin.csushi 245

452947 AW130413 gb xf50f04 x1 NCI CGAP Gas4 Hom alpha-amylase 15 8

418092 R45154 Hs 106604 ESTs pkιnase,Actιvιn_recp 151

431725 X65724 Hs 2839 Nome disease (pseudoglioma) Cys knot 126

422330 D30783 Hs 115263 epiregulin EGF 125

446745 AW1181B9 Hs 156400 ESTs vwa 11 1

416319 AI815601 Hs 79197 CD83 antigen (activated B lymphocyt ig 108

432408 N39127 Hs 76391 myxovirus (influenza) resistance 1, ho ion trans K tetra 106

405285 predicted exon A2M A2M.N 105

405636 predicted exon EGFJdl recepLa.ldl recepLb 98

403093 predicted exon fn3 96

446740 AI611635 Hs 192605 ESTs RYDRJTPR 92

405547 predicted exon ABC tran.ABC membrane 85

412333 AW937485 gb QV3-DT0044-221299 045-b09 DT 7tm 1 84

404270 predicted exon SCP 81

402745 predicted exon EGF,ldl_recept_b,thyroglobulιπ_1 81

452755 AW138937 Hs 213436 ESTs cystatin 80

421459 AI821539 Hs 97249 ESTs disintegππ.Reprolysin 79

416151 T26661 gb AB65C7R Infant brain, LLNL arra lamiπiπ G.EGF 78

446232 AI281848 Hs 165547 ESTs 7tm_3 76

431009 BE149762 Hs 248213 gap junction jjrotein, beta 6 (connexin connexin 72

424634 NM.003613 Hs 151407 cartilage intermediate layer protein, n ιg,tsp_1 7 1

400749 predicted exon fn3,ldl recept_a,ldl_recep b 68

419054 N40340 Hs 191510 ESTs, Weakly similarto ORF2 [M m ig.SPRY 68

459170 AI905518 gb RC-BT091-210199-098 BT091 Ho ABC tran.ABC membrane 66

416441 BE407197 gb 601301552F1 NIH.MGC.21 Horn SDF 64

410664 NM.006033 Hs 65370 lipase, endothelial Rιbosomal_L22 64

402425 predicted exon lonjrans 63

415451 H19415 Hs 268720 ESTs, Moderately similar to ALU1.H Ephnn 60

403083 predicted exon fn3 59

448995 AI613276 Hs 5662 guanine nucleotide binding protein (G SDF 59

418345 AJ001696 Hs 241407 seπne (or cysteine) prateinase inhibito serpm 58

424966 AU077312 Hs 153985 solute camerfamily 7 (cationic ammo aa_permeases 58

431211 M86849 Hs 5566 gap junction protein, beta 2, 26kD (co connexin 57

430563 AA481269 Hs 178381 ESTs ABC.tran.ABC.membrane 56

450152 AI138635 Hs 22968 ESTs ig.pkinase 56

418844 M62982 Hs 1200 arachidoπate 12-lιpoxygenase lipoxygenase.PLAT 56

403089 predicted exon fn3 56

403687 predicted exon tsp_1,Reprolysιπ 56

403691 predicted exon tsp_1,Reprolysιn 55

414035 Y00630 Hs 75716 seπne (or cysteine) prateinase inhibito serpm 54

421284 U62435 Hs 103128 cholinergic receptor, nicotinic, alpha p neur.chan 53

435435 T89473 Hs 192328 ESTs lipase.PLAT 53

457122 AI026157 Hs 33728 ESTs, Weakly similar to ALU1.HUM lipoxygenase.PLAT 52

419249 X14767 Hs 89768 gamma aminobutyπc acid (GABA) A neur.chan 52

425698 NM 016112 Hs 159241 polycystic kidney disease 2-lιke 1 ion trans 52

431117 AF003522 Hs 250500 delta (Drosophιla)-lιke 1 EGF.DSL 51

457948 AI498640 Hs 159354 ESTs G-alpha,arf 5 1

435174 AA687378 Hs 194624 ESTs SPRY 50

408170 AW204516 Hs 31835 ESTs arf.ras 50

434351 AW974991 Hs 191852 ESTs, Weakly similar to ALU1JHUM arf.ras 49

430708 U78308 Hs 278485 olfactory receptor, family 1, subfamily 7tm_1 48

422597 BE245909 Hs 118634 ATP-bindiπg cassette, sub-family B (M ABC.tran.ABC.membrane 48

405545 predicted exon ABC tran.ABC membrane 48

426471 M22440 Hs 170009 transforming growth factor, alpha EGF 47

409632 W74001 Hs 55279 seπne (or cysteine) prateinase inhibito serpm 47

420206 M91463 Hs 95958 solute earner family 2 (facilitated glue sugar.tr 46

415138 C18356 Hs 78045 tissue factor pathway inhibitor 2 Kunifz BPTI.G gamma 46

424402 M63108 Hs 1769 luteinizing hormoπe/choπogonadotrop 7tm 1 45

436480 AJ271643 Hs 87469 putative acid-sensing ion channel ASC 45

430226 BE245562 Hs 2551 adrenergic, beta-2-, receptor, surface 7tm 1 44

436126 AW449757 Hs 163036 ESTs SNF 44

406812 AF000575 Hs 67846 leukocyte immunoglobulin-like recep ig 44

409385 AA071267 gb zm61g01 r1 Stratagene fibroblast ( TIMP 43

449184 AW296295 Hs 196491 ESTs TNFR_c6 43

410555 U92649 Hs 64311 a dismtegπn and metalloprotemase do disintegπn.Reprolysin 43

422389 AF240635 Hs 115897 protocadheπn 12 cadheπn 43

405281 predicted exon A2M.A2M.N 43

413548 BE147555 Hs 288541 Homo sapiens mRNA for KIAA1558 EGF,ldl_recept_a,ldl_recept_b 43

449535 W15267 Hs 23672 low density lipoprotein receptor-relate Idl recep a EGF.Idl recepLb 43

425864 U56420 Hs 159903 olfactory receptor, family 5, subfamily 7tm_1 43

410611 AW954134 Hs 20924 KIAA1628 protein Peptιdase_S9 42

430686 NM 001942 Hs 2633 desmoglein 1 cadheπn.Cadheπn.C.term 41

418693 A1750878 Hs 87409 thrombospondm 1 vwc.TSPN 40

445924 AI264671 Hs 164166 ESTs sugar.tr 39

457148 AF091035 Hs 184627 KIAA0118 protein arfjras 39

428568 AC004755 Hs 184922 one cut domain, family member 3 E1-E2_ATPase 39

412170 D16532 Hs 73729 very low density lipoprotein receptor EGF,ldl_recept_a,ldl_recept_b 38

442566 R37337 Hs 12111 ESTs ank,dealh,RHD,TIG 38

403763 predicted exon 7tm_1 38 403074 predicted exon fn3 38

413605 BE152644 gb CM1-HT0329-250200-128-f09 HT alpha-amylase 38

442295 AI827248 Hs 224398 Homo sapiens cDNA FU11469 fis, c Collageπ.COLFI 37

403661 predicted exon 7tm_3,ANF_receptor 37

407305 AA715284 gb nv35f03 ri NCI.CGAP.Br5 Horn pkιnase,Sema,Plexιn_repeat,TIG 37

457353 X65633 Hs 248144 melanocortin 2 receptor (adreπocortic 7tm_1 37

431176 AI026984 Hs 293662 ESTs laminin.EGF.Iaminm.B 36

436233 AI742878 Hs 124116 ESTs ig 36

431808 M30703 Hs 270833 amphiregulin (schwannoma denved g EGF 36

445798 NM 012421 Hs 13321 rearranged L-myc fusion sequence zf-C2H2 36

400380 NM 018485 Hs 283079 G protein-coupled receptor C5L2 7tm_1 36

453893 NM 000835 Hs 36451 glutamate receptor, lonotropic, N-met lig.chan 35

409402 AF208234 Hs 695 cystatin B (stefin B) cystatin 35

421166 AA305407 Hs 102308 potassium inwardly-rectifying channe IRK 35

445575 Z25368 Hs 172004 titiπ fh3 35

428957 NM 003881 Hs 194679 WNT1 inducible signaling pathway p tsp_1,vwc,IGFBP 35

403909 NM.016255 Hs 95260 Homo sapiens mRNA, cDNA DKFZp Na H Exchanger 35

403077 predicted exon fh3 35

455612 BE042896 Hs 274848 ESTs ABC.tran.ABC.membrane 35

424091 AF235097 Hs 139263 calcium channel, voltage-dependent, a lon.trans 35

403956 W28077 Hs 79389 nel (chιcken)-lιke 2 cadheπn.Cadheπn.C.ter 34

457470 AB040973 Hs 272385 G protein-coupled receptor 72 7tm_1 34

401522 N47812 Hs 81360 CGI-35 protein disintegrin.Reprolysm 34

404886 predicted exon ion trans 34

437692 AA176959 Hs 172004 titin fn3 34

407944 R34008 Hs 239727 desmocollιn 2 cadheπn 34

407393 AB038237 gb Homo sapiens mRNA for G prolei 7tm_1 33

436936 AL134451 Hs 197478 ESTs EGF.Iaminm.G 33

423309 BE006775 Hs 126782 sushi-repeat protein sushι,HYR 33

402172 predicted exon "9 33

447420 AI378628 gb tc72g07 x1 Soares NhHMPu S1 H ank,pkιnase,death 33

438901 AF085834 Hs 29036 ESTs sushi 33

424362 AL137646 Hs 146001 Homo sapiens mRNA, cDNA DKFZp trypsin.sushi.CUB 33

430453 BE387060 Hs 3903 Cdc42 effector protein 4, binder of Rh fπ3 33

416631 H69466 gb yr88f07 r1 Soares fetal liver spleen Idl recept_a,MACPF 33

453174 AI633529 Hs 135238 ESTs 7tm_1 33

433848 AF095719 Hs 93764 carboxypeptidase A3 Zn_carbOpept,Propep_M14 32

408546 W49512 Hs 46348 bradykmin receptor B1 7tm 1 32

423573 AA328504 gb EST31993 Embryo, 12 week I Horn 7tm_1 32

458662 AI823410 Hs 169149 karyophenn alpha 1 (importin alpha 5 7tm_3,ANF_receptor 32

433430 AI863735 Hs 186755 ESTs thyroglobulmJ.IGFBP 32

438850 R33727 Hs 24688 EST ank,pkιnase,death 32

420783 AI659838 Hs 99923 leclin, galactoside binding, soluble, 7 Gal-bindjectin 32

409968 U56102 Hs 57699 adhesion glycoprotein ■9 3 1

430630 AW269920 Hs 2621 cystatin A (stefin A) 7tm 3,ANF_receptor 3 1

420737 L08096 Hs 99899 tumor necrosis factor (ligand) superfa TNF 31

422279 H69644 Hs 114231 C-type lectin-like receptor-2 lectiπ.c 31

400289 X07820 Hs 2258 matπx metalloproteiπase 10 (stromely hemopexm.Peptidase M10 31

412597 AU077051 Hs 74561 alpha-2-macraglobulιn A2M.A2M.N 31

453420 AJ003459 gb AJ003459 Selected chromosome 2 IRK 3 1

404243 predicted exon zf-C3HC4,SPRY,zf-B_box 31

449987 AW079749 Hs 184719 ESTs, Weakly similar to AF116721 1 ABC.tran.ABC.membrane 31

422471 AA311027 Hs 271894 ESTs ig 30

400464 predicted exon Peptιdase_S9 30

458713 BE044496 Hs 282707 ESTs EGF 30

421340 F07783 Hs 1369 decay accelerating factor for complem sushi 30

449523 NM.000579 Hs 54443 chemokine (C-C motif) receptor 5 7tm_1 30

400704 predicted exon lιg_chan,ANF_receptor 30

416239 AL038450 Hs 48948 ESTs E1-E2_ATPase,Hydrolase 30

433664 AW292176 Hs 245834 ESTs Ricin.BJectm 30

423994 X01057 Hs 1724 interleukin 2 receptor, alpha rrm 29

447726 AL137638 Hs 19368 Homo sapiens mRNA, cDNA DKFZp vwa 29

425483 AF231022 Hs 301273 Homo sapiens protocadheπn Fat 2 (FA EGF,cadheπn,lamιnιn_G 29

423513 AF035960 Hs 129719 transglutammase 5 Transglut_core,Transglutamιn_N 29

401537 predicted exon ιg,pkιnase,LRRNT,LRRCT 29

405790 predicted exon Sema,PIexιn_repeat,TIG 29

422669 H12402 Hs 119122 πbosomal protein L13a arf.ras.Ribosomal S17 29

430793 M83181 Hs 247940 5-hydroxytryptamιne (serotonin) recep 7tm_1 29

403411 predicted exon ABC.tran.ABC.membrane 28

428188 M98447 Hs 22 transglutammase 1 (K polypeptide ep Traπsglutamtn N.Transglut core 28

414482 S57498 Hs 76252 endothelm receptor type A 7tm_1 28

427223 BE208189 Hs 174031 cytochrome c oxidase subunit Vlb COX6B 28

404187 predicted exon 19 28

443537 D13305 Hs 203 cholecystokiπin B receptor 7tm_1 28

428701 NM.013276 Hs 190207 carbohydrate kinase like vwa.mtegπn A.P2X receptor 27

411213 AA676939 Hs 69285 neuropilin 1 CUB,MAM,F5_F8_type_C 27

453999 BE328153 Hs 240087 ESTs kazal 27

401244 predicted exon vwa.vwd.TIL 27

458930 NM 003612 Hs 24640 sema domain, immunoglobulin domai Sema 27

434411 AA632649 Hs 201372 ESTs sushi 27

400421 AF263537 Hs 287370 fibroblast growth factor 23 FGF 27

448999 AF179274 Hs 22791 transmembrane protein with EGF-like kazal 27

417350 U50928 Hs 82001 polycystic kidney disease 2 (autosoma loπ rans 26

419452 U33635 Hs 90572 PTK7 protein tyrosine kinase 7 pkinase.ig 26 401657 predicted exon 7tm_1 26

456711 AA033699 Hs 83938 ESTs, Moderately similar to MASP-2 sushi.trypsin.CUB 26

432042 AW971345 Hs 292715 ESTs sugar.tr 26

433138 AB029496 Hs 59729 semaphoπn sem2 ig.Sema 26

452530 AI905518 gb RC-BT091-210199-098 BT091 Ho ABC.tran.ABC.membrane 26

426418 M90464 Hs 169825 collagen, type IV, alpha 5 (Alport syn Collagen,C4 26

403796 predicted exon cadheπn 26

431728 NM 007351 Hs 268107 multimeπn EGF,C1q 26

441595 AW206035 Hs 192123 ESTs sugar.tr 26

445537 AJ245671 Hs 12844 EGF-like-domain, multiple 6 EGF.MAM 26

447197 R36075 gb yh88b01 s1 Soares placenta Nb2H SDF 25

428765 X54150 Hs 193122 Fc fragment of IgA, receptor for '9 25

450245 AA007536 Hs 271767 ESTs, Moderately similar to ALU1.H ig 25

416429 H54658 Hs 268942 ESTs E1-E2_ATPase,Hydrolase 25

417067 AJ001417 Hs 81086 solute earner family 22 (extraneurona sugar.tr 25

433182 AB039920 Hs 127821 BWRT protein ion trans 25

403092 predicted exon fn3 25

406850 AI624300 Hs 172928 collagen, type I, alpha 1 vwc.CoIlagen.COLFI 25

438698 AW297855 Hs 125815 ESTs lipoxygenase.PLAT 25

456815 NM.013348 Hs 144011 potassium inwardly-rectifying channe IRK 25

TABLE 2B

Pkey Unique Eos probeset identifier number CAT number Gene cluster number Accession Genbank accession numbers

Pkey CAT Number Accession 409385 112523 1 AA071267 T65940 T64515 AA071334 412333 1289037.1 AW937485 AW937589 AW937658 AW937654 AW937492 413605 1379792 1 BE152644 BE152712 BE152668 BE152659 BE152810 BE152811 BE152816 BE152643 BE152706 BE152656 BE152660 BE152715 BE152662

BE152669 BE152661 BE152672 BE152653 BE152716 BE152651 BE152767 BE152677 BE152652 BE152714 BE152708 BE152665 BE152679

BE152771 BE152775 BE152666 BE152768 BE152813 BE152664 BE152676 BE152681 BE152709 BE152667 BE152814 BE152808 BE152711

BE152707 BE152815 BE152678 BE152673 BE152782 BE152671 BE152682 BE152760 BE152809 BE152778 BE152780 BE152762 BE152776

BE152781 BE152774 BE152763 BE152769

416151 1573926 1 T26661 244135 H23016

416441 159480 1 BE407197 AA182474 AA180369 BE275628 BE276131

416631 1605019 1 H69466 H93884 N59684

423573 229714 1 AA328504 AA327783 AW962370

447197 711623 1 R36075 AI366546 R36167

447420 721207 1 AI378628 N32350 H85772

452530 920646 1 AI905518 AI905516 AI905457 AI905515 AW176013 AW176037

452947 939810 1 AW130413 AI932362

453420 966433 1 AJ003459 AJ003461

459170 920646 1 AI905518 AI905516 AI905457 AI905515 AW176013 AW176037

TABLE 2C

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham I et al " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495 Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons

Pkey Ref Strand Nt position

400464 9929670 Plus 22074-22214

400704 8118864 Minus 63110-63241

400749 7331445 Minus 9162-9293

401244 4827300 Minus 55359-56376

401537 7960358 Minus 186786-187029,190607-190779,198218-198348

401657 9100664 Minus 7312-8163

402172 8575911 Minus 143378-143671

402425 9796347 Minus 50224-50395

402745 9212200 Minus 76516-76690

403074 8954241 Plus 143375-143561

403077 8954241 Plus 146923-147222,147326-147628

403083 8954241 Plus 163070-163351

403089 8954241 Plus 171964-172239

403092 8954241 Plus 174720-175016,175104-175406,175508-175813

403093 8954241 Plus 177083-177373,177464-177751

403411 9438635 Minus 104247-104420

403661 8705027 Minus 30268-30482

403687 7387384 Plus 9009-9534

403691 7387384 Minus 88280-88463

403763 7229888 Minus 43575-43887

403796 8099896 Minus 75073-77664

404187 4481839 Plus 7644-7991

404243 5672609 Plus 74695-75123

404270 9828129 Minus 3649-3750,4161-4306,5962-6049,6849-6965

404886 4884062 Plus 30058-30596

405281 6139075 Minus 34202-34351,35194-35336,45412-45475,45731-45958,47296-47457,49549-49658,49790-49904,50231-50342,53583-53667,54111 54279

405285 6139075 Minus 55744-55903,57080-57170.61478-61560

405545 1054740 Plus 118677-118807,119091-119296,121626-121823

405547 1054740 Plus 124361-124520,124914-125050

405636 5123990 Plus 56384-56587 405790 1203968 Plus 136364-136509,136579-136699,136805-136941

TABLE 3A lists about 1643 genes up-regulated in ovanan cancer compared to normal ovanes These were selected as for Table 1A, except that the ratio was greater than or equal to 15, and the denominator was the aπthmetic mean value for vaπous non malignant ovary specimens obtained

TABLE 3A ABOUT 1643 UP-REGULATED GENES, OVARIAN CANCER VERSUS NORMAL OVARY

Pkey Pπmekey

Ex Accn Exemplar Accession

UG ID UniGene lD

Title Unigene Title

PFAM domains ratio tumor vs normal tissues

P Pkkeeyy E Exx AAccccnn NNoo U UGG IIDD Title ratio

420859 AW468397 Hs 100000 S100 calcium binding protein A8 (calgranul A) 219 9

422166 W72424 Hs 112405 S100 calcium-binding protein A9 (calgranulm B) 1802

422158 L10343 Hs 112341 protease inhibitor 3, skm-deπved (SKALP) 1650

424799 BE550723 Hs 153179 fatty acid binding protein 5 (psoπasis associated) 161 5

4 44422440022 N NMM..000000995544 H Hss 88227722 prostaglandin D2 synthase (21kD, brain) 1502

408522 AI541214 Hs 46320 Small prolme-πch protein SPRK [human, odontogenic k 1495

431369 BE184455 Hs 251754 secretory leukocyte protease inhibitor (antileukoprotein 1449

430520 NM.016190 Hs 242057 chromosome 1 open reading frame 10 1366

428471 X57348 Hs 184510 stratifin 1295

421978 AJ243662 Hs 110196 NICE-1 proteig 1087

437191 NM 006846 Hs 5476 seπne protease inhibitor, Kazal type 5 1062

407788 BE514982 Hs 38991 S100 calcium binding protein A2 1055

441565 AW953575 Hs 169902 solute camerfamily 2 (facilitated glucose transporter), 103 6

431211 M86849 Hs 5566 gap junction protein, beta 2, 26kD (connexin 26) 102 1

419329 AY007220 Hs 288998 S100-type calcium binding protein A14 953

430572 U33114 Hs 245188 tissue inhibitor of metalloproteinase 3 (Sorsby fundus d 870

417079 U65590 Hs 81134 interieukin 1 receptor antagonist 86 1

412636 NM.004415 Hs 74316 desmoplakin (DPI, DPII) 850

417515 L24203 Hs 82237 ataxta-telangiectasia group D associated protein 848

426295 AW367283 Hs 75839 zinc finger protein 6 (CMPX1) 845

452669 AA216363 Hs 262958 ESTs, Weakly similar to alternatively spliced product u 844

406711 N25514 Hs 77385 myosin, light polypeptide 6, alkali, smooth muscle and n 838

406712 M31212 Hs 77385 myosm, light polypeptide 6, alkali, smooth muscle and n 81 0

432680 T47364 Hs 278613 interferon, alpha inducible protein 27 81 0

416889 AW250318 Hs 80395 mal, T-cell differentiation protein 778

409453 AI885516 Hs 95612 ESTs 753

424670 W61215 Hs 116651 epithelial V like antigen 1 675

417130 AW276858 Hs 81256 S100 calcium binding protein A4 (calcium protein, calv 670

423634 AW959908 Hs 1690 hepaπn binding growth factor binding protein 657

442379 NM 004613 Hs 8265 transglutammase 2 (C polypeptide, protein-glutamine-g 647

456898 NM 001928 Hs 155597 D component of complement (adipsm) 646

423017 AW178761 Hs 227948 seππe (or cysteine) prateinase inhibitor, clade B (ovalbu 636

447990 BE048821 Hs 20144 small inducible cytokine subfamily A (Cys Cys), memb 607

424362 AL137646 Hs 146001 Homo sapiens mRNA, cDNA DKFZp586F0824 (from 603

414438 AI879277 Hs 76136 thioredoxiπ 599

420136 AW801090 Hs 195851 actin, alpha 2, smooth muscle, aorta 589

433336 AF017986 Hs 31386 ESTs, Highly similar to JE0174 frizzled protein 2 [H sa 588

403741 predicted exon 570

430637 BE160081 Hs 256290 S100 calcium binding protein A11 (calgizzaπn) 56 1

424098 AF077374 Hs 139322 small proline πch protein 3 558

441591 AF055992 Hs 183 Duffy blood group 556

426521 AF161445 Hs 170219 hypothetical protein 555

406713 U02629 Hs 77385 myosin, light polypeptide 6, alkali, smooth muscle and n 553

406725 D51245 Hs 288061 actin, beta 54 1

422168 AA586894 Hs 112408 SlOOcalcium binding protein A7 (psonasin 1) 54 1

406755 N80129 Hs 94360 metallothionein lL 540

425593 AA278921 Hs 1908 proteoglycaπ 1 , secretory granule 533

442257 AW503831 gb UI HF-BN0 alb-b-05-O-UI r1 NIH.MGC.50 Homo 531

421957 AW068637 Hs 109857 hypothetical protein DKFZp434H0820 523

447526 AL048753 Hs 340 small inducible cytokine A2 (monocyte chemotactic pro 51 2

406722 H27498 Hs 283305 Homo sapiens SNC73 protein (SNC73) mRNA, comple 51 0

427223 BE208189 Hs 174031 cytochrome c oxidase subunit Vlb 51 0

414420 AA043424 Hs 76095 immediate early response 3 509

417259 AW903838 Hs 81800 chondroitin sulfate proteoglycan 2 (versican) 503

414191 AW250089 Hs 75807 PDZ and UM domain 1 (elfin) 495

436906 H95990 Hs 181244 major histocompatibility complex, class I, A 490

408000 L11690 Hs 620 bullous pemphigoid antigen 1 (230/240kD) 490

414035 Y00630 Hs 75716 seπne (or cysteine) prateinase inhibitor, clade B (ovalbu 488

432706 NM 013230 Hs 286124 CD24 antigen (small cell lung carcinoma cluster 4 antig 488

421948 L42583 Hs 111758 keratin 6A 487

414662 AL036058 Hs 76807 major histocompatibility complex, class II, DR alpha 485

425071 NM.013989 Hs 154424 deiodmase, lodothyroπine, type II 485

404767 predicted exon 484

418327 U70370 Hs 84136 paired like homeodomain transcπption factor 1 482

436729 BE621807 Hs 3337 transmembrane 4 superfamily member 1 477

414183 AW957446 Hs 301711 ESTs 472

400163 predicted exon 470

433423 BE407127 Hs 8997 heat shock 70kD protein 1 A 469

423457 F08208 Hs 155606 paired mesoderm homeo box 1 466 414085 AA114016 Hs 75746 aldehyde dehydrogenase 6 460

423188 M59371 Hs 171596 EphA2 456

438240 N92638 Hs 124004 ESTs 455

417366 BE185289 Hs 1076 small praline-πch protein 1B (cornifin) 453

412774 AA120865 Hs 23136 ESTs 451

407242 M18728 gb Human nonspecific crassrextmg antigen mRNA, co 448

431282 AA370141 Hs 251453 Human DNA sequence from clone 967N21 on chromos 448

403695 predicted exon 435

417365 D50683 Hs 82028 transforming growth factor, beta receptor II (70 80kD) 434

432331 W37862 Hs 274368 Homo sapiens mRNA, cDNA DKFZp586H524 (from c 434

424479 AF064238 Hs 149098 smoothelm 433

444726 NM.006147 Hs 11801 interferon regulatory factor 6 432

432314 AA533447 Hs 285173 ESTs 43 2

429500 X78565 Hs 289114 hexabrachion (teπascm C, cytotactin) 43 1

441406 Z45957 Hs 7837 Homo sapiens cDNA FLJ10457 fis, clone NT2RP1001 427

412969 AI373162 Hs 75103 tyrosine 3-monooxygenase/tryptophan 5-monooxygenas 426

423720 AL044191 Hs 23388 Homo sapiens cDNA FU21310 fis, clone COL02160 42 5

400111 predicted exon 424

407207 T03651 Hs 179661 tubulin, beta polypeptide 424

417164 AA338283 Hs 81361 heterogeneous nuclear πbonucleoproteiπ A/B 422

424971 AA479005 Hs 154036 tumor suppressing subtransferable candidate 3 41 9

439394 AA149250 Hs 56105 ESTs, Weakly similar to WDNM RAT WDNM1 PROT 41 9

406657 AI678644 Hs 277477 major histocompatibility complex, class I, C 41 8

451092 AI207256 Hs 13766 Homo sapiens mRNA for FLJ00074 protein, partial eds 41 6

412596 AA161219 Hs 799 diphtheπa toxin receptor (hepaπn binding epidermal gro 41 6

422103 AA984330 Hs 111676 protein kmase^'H11, small stress protein-like protein HS 41 5

428785 AI015953 Hs 125265 ESTs 41 3

450988 BE618571 Hs 429 ATP synthase, H+ transporting, mitochondπal F0 comp 41 0

414522 AI752666 Hs 76669 nicotinamide N-methyltransferase 40 8

405022 predicted exon 40 8

408221 AA912183 Hs 47447 ESTs 40 8

446500 U78093 Hs 15154 sushi-repeat-contaming protein, X chromosome 407

421416 BE302850 Hs 104125 adenylyl cyclase-associated protein 406

412247 AF022375 Hs 73793 vascular endothelial growth factor 405

410541 AA065003 Hs 64179 hypothetical protein 405

406658 AI920965 Hs 77961 major histocompatibility complex, class I, B 400

420225 AW243046 Hs 94789 ESTs 400

406825 AI982529 Hs 84298 CD74 antigen (invariant polypeptide of major histocom 394

443623 AA345519 Hs 9641 complement component 1, q subcomponent, alpha poly 394

404201 AF059566 Hs 103983 solute earner family 5 (sodium iodide symporter), mem 393

405138 predicted exon 39 1

408733 AW264812 Hs 254290 ESTs 390

414044 BE614194 Hs 75721 profilin 1 389

430152 AB001325 Hs 234642 aquapoπn 3 388

428121 AB006622 Hs 182536 Homo sapiens cDNA FLJ21370 fis, clone COL03092 38 8

434311 BE543469 Hs 266263 Homo sapiens cDNA FLJ14115 fis, clone MAMMA10 387

406140 predicted exon 38 5

432918 AF077200 Hs 279813 hypothetical protein 384

420107 AL043980 Hs 7886 peiliπo (Drosophila) homolog 1 384

427693 BE546832 Hs 180370 cofilin 1 (non-muscle) 38 1

448835 BE277929 Hs 11081 ESTs, Weakly similar to S57447 HPBRII-7 protein [H 38 1

432374 W68815 Hs 301885 Homo sapiens cDNA FLJ11346 fis, clone PLACE1010 379

428383 BE616599 Hs 184029 hypothetical protein DKFZp761A052 37 7

436258 AW867491 Hs 107125 ESTs, Weakly similar to S57447 HPBRII-7 protein [H 377

420798 W93774 Hs 99936 keratin 10 (epidermolytic hyperkeratosis, keratosis palm 377

400327 M18679 Hs 247942 Human vanant 5S rRNA like gene and ORF, complete 376

401781 predicted exon 376

448257 AW772070 Hs 253146 ESTs 37 3

428415 AA337211 Hs 184222 Down syndrome cπtical region gene 1 372

424206 NM 003734 Hs 198241 amine oxidase, copper containing 3 (vascular adhesion p 372

406812 AF000575 Hs 67846 leukocyte immunoglobulin like receptor, subfamily B ( 372

425882 U83115 Hs 161002 absent in melanoma 1 372

432501 BE546532 Hs 287329 Fas binding protein 1 37 1

421786 AI188653 Hs 21351 ESTs 371

427981 BE275886 Hs 181311 asparagmyl-tRNA synthetase 370

410143 AA188169 Hs 288819 Homo sapiens cDNA FU21022 fis, clone CAE06383 368

451328 AW853606 Hs 109012 ESTs 367

414135 NM 004419 Hs 2128 dual specificity phosphatase 5 367

414602 AW630088 Hs 76550 Homo sapiens mRNA, cDNA DKFZp564B1264 (from 367

401785 predicted exon 365

411469 T09897 Hs 70327 cysteine-πch protein 2 36 2

419693 AA133749 Hs 82323 FXYD domain-containing ion transport regulator 3 36 1

417039 AA302180 Hs 80986 ATP synthase, H+ transporting, mitochondπal F0 comp 36 1

406718 AA505525 Hs 169476 glyceraldehyde 3-phosphate dehydrogenase 360

402543 predicted exon 36 0

408669 AI493591 Hs 78146 platelet endothelial cell adhesion molecule (CD31 antig 359

414987 AA524394 Hs 165544 ESTs 359

445810 AW265700 Hs 155660 ESTs 359

406653 AA574074 Hs 77961 major histocompatibility complex, class I, B 357

407498 U28131 gb Human HMGI-C chimenc transcπpt mRNA, partial 356

412524 AA417813 Hs 11177 ESTs 355

401521 predicted exon 354

408948 AW296713 Hs 221441 ESTs 35 1

406728 AI986345 Hs 183704 ubiquitin C 349 440668 AI206964 gb qr30g06 x1 NCI_CGAP_GC6 Homo sapiens cDNA 348

422658 AF231981 Hs 250175 homolog of yeast long chain polyuπsaturated fatty acid 348

452924 AW580939 Hs 97199 complement component C1 receptor 347

428600 AW863261 Hs 15036 ESTs, Highly similarto AF161358 1 HSPC095 [H sapi 347

409828 AW501137 gb UI-HF-BPOp-aιt-e-12-O-UI r1 NIH MGC 51 Homo 345

459390 BE385725 gb 601276347F1 NIH.MGC.20 Homo sapiens cDNA 345

445055 BE512856 Hs 109051 glycoprotein, synaptic 2 343

411789 AF245505 Hs 72157 Homo sapiens adlican mRNA, complete eds 343

410626 BE407727 gb 601299771 F1 NIH MGC 21 Homo sapiens cDNA 342

410706 AI732404 Hs 68846 ESTs 342

419273 BE271180 Hs 293490 ESTs 342

407839 AA045144 Hs 161566 ESTs 340

444286 AI625304 Hs 190312 ESTs 340

449226 AB002365 Hs 23311 KIAA0367 protein 340

414290 AI568801 Hs 71721 ESTs 339

401245 predicted exon 339

425222 M85430 Hs 155191 villiπ 2 (ezππ) 33 8

409950 R42678 Hs 301669 KIAA0564 protein 33 8

437201 F29279 Hs 177486 amyloid beta (A4) precursor protein (protease nexm-ll, 337

406566 AF088886 Hs 11590 cathepsin F 337

405071 predicted exon 337

455426 AW937792 gb QV3-DT0045-140200 082-b07 DT0045 Homo sapi 33 6

415160 T82802 gb yd38a04 r1 Soares fetal liver spleen 1 NFLS Homo s 335

424995 Z45023 gb HSC2FA041 normalized infant brain cDNA Homo s 335

453870 AW385001 Hs 8042 Homo sapiens cDNA FLJ23173 fis, clone LNG10019 335

433470 AW960564 Hs 3337 transmembrane 4 superfamily member 1 334

428188 M98447 Hs 22 transglutammase 1 (K polypeptide epidermal type 1, pro 333

417409 BE272506 Hs 82109 syndecan 1 333

425389 AW974499 Hs 192183 ESTs 333

434658 AI624436 Hs 194488 ESTs 33 2

456562 AA306049 Hs 102669 DKFZP4340125 protein 33 1

447111 AI017574 Hs 17409 cysteine-πch protein 1 (intestinal) 330

432360 BE045243 Hs 274416 NADH dehydrogenase (ubiqumone) 1 alpha subcomple 329

424125 M31669 Hs 1735 inhibm, beta B (activin AB beta polypeptide) 327

419968 X04430 Hs 93913 interieukin 6 (interferon, beta 2) 327

429415 NM 002593 Hs 202097 procollagen C-endopeptidase enhancer 326

451541 BE279383 Hs 26557 plakophilm 3 326

424499 N90344 Hs 149436 kinesiπ family member 5B 324

402144 predicted exon 324

422511 AU076442 Hs 117938 collagen, type XVII, alpha 1 324

400231 predicted exon 323

437712 X04588 Hs 85844 neurotraphic tyrosine kinase, receptor, type 1 323

417433 BE270266 Hs 82128 5T4 oncofetal trophoblast glycoprotein 322

419659 AB023206 Hs 92186 Leman coiled-coil protein 320

428582 BE336699 Hs 185055 BENE protein 320

421401 AW410478 Hs 104019 transforming, acidic coiled-coil containing protein 3 320

414064 BE245289 Hs 16165 expressed in activated T/LAK lymphocytes 320

431938 AA938471 Hs 115242 developmental^ regulated GTP-binding protein 1 320

411930 F06485 gb HSC19G051 normalized infant brain cDNA Homo s 31 9

428150 AW950547 Hs 182684 cytochrome c oxidase subunit Vila polypeptide 2 (liver) 31 8

401887 predicted exon 31 8

412570 AA033517 Hs 74047 electron-transfer-flavoprotein, beta polypeptide 31 7

422738 X80915 Hs 1573 growth differentiation factor 5 (cartilage-derived morph 31 6

453092 X64838 Hs 31638 restin (Reed-Steinberg cell-expressed intermediate filam 31 5

413924 AL119964 Hs 75616 KIAA0018 gene product 31 4

420231 R06866 Hs 19813 ESTs 31 3

434715 BE005346 Hs 116410 ESTs 31 3

422831 R02504 gb ye86f06 ri Soares fetal liver spleen 1 NFLS Homo sa 31 2

416854 H40164 Hs 80296 Purkinje cell protein 4 31 2

422976 AU076657 Hs 1600 sec61 homolog 31 1

426356 BE536836 gb 601064837F1 NIH.MGC.10 Homo sapiens cDNA 31 0

433935 AF112208 Hs 44163 13kDa differentiation-associated protein 30 8

430040 AW503115 Hs 227823 pM5 protein 308

406340 AA299678 Hs 180370 cofilin 1 (non-muscle) 308

426050 AF017307 Hs 166096 E74-lιke factor 3 (ets domain franscπption factor, epith 307

425105 BE280066 Hs 24956 hypothetical protein FU22056 307

402066 predicted exon 307

429538 BE182592 Hs 139322 small proline-πch protein 3 306

418371 M13560 Hs 84298 CD74 antigen (invaπant polypeptide of major histocom 304

421251 Z28913 Hs 102948 enigma (UM domain protein) 303

456084 AA155859 Hs 79708 ESTs 303

402023 predicted exon 303

404356 predicted exon 302

415973 R24707 Hs 260201 ESTs 302

445983 AI269107 Hs 132219 ESTs 301

450440 AB024334 Hs 25001 tyrosine 3 monooxygenase/tryptophan 5-monooxygenas 30 1

458789 AL157468 Hs 20157 Homo sapiens cDNA FU20848 fis, clone ADKA01732 301

400842 predicted exon 301

406828 AA419202 Hs 84298 CD74 antigen (mvaπant polypeptide of major histocom 300

423267 AL137416 Hs 126177 Homo sapiens mRNA, cDNA DKFZp4340192 (from c 300

451383 AW239364 Hs 20242 hypothetical protein FU12788 300

437042 AK000702 Hs 5420 hypothetical protein FU20695 300

459399 BE407712 gb 601299745F1 NIH.MGC.21 Homo sapiens cDNA 300

425650 NM 001944 Hs 1925 desmoglein 3 (pemphigus vulgaπs antigen) 300 416511 NM.006762 Hs79356 Lysosomal-associated multispaπniπg membrane protein 299

431009 BE149762 Hs 248213 gap junction protein, beta 6 (connexin 30) 297

436651 BE045962 Hs 275998 ESTs 296

419766 BE243101 Hs 22391 chromosome 20open reading frame 3 295

420747 BE294407 Hs 99910 phosphofructokinase, platelet 295

436895 AF037335 Hs 5338 carbonic aπhydrase XII 295

412765 AK000620 Hs74571 ADP-πbosylatιon fxtor 1 294

419223 X60111 Hs1244 CD9 antigen (p24) 294

413796 AW408094 Hs 75545 interleukin 4 receptor 294

447795 AW295151 Hs 163612 ESTs 294

431103 M57399 Hs44 pleiotrophm (hepaπn binding growth factor 8, neuπte g 294

415314 N88802 Hs 5422 glycoprotein M6B 293

428411 AW291464 Hs 10338 ESTs 293

430580 AA806105 Hs 40 immunoglobulin heavy constant gamma 3 (Gm marker) 29 3

430451 AA836472 Hs 249982 cathepsin B 292

453949 AU077146 Hs 36927 heat shock 105kD 29 2

413859 AW992356 Hs8364 pyruvate dehydrogenase kinase, isoenzyme 4 29 2

407845 AL036518 Hs 118598 ESTs 29 1

453500 AI478427 Hs43125 ESTs 29 1

456054 BE313241 gb 601151545F1 NIH MGC.18 Homo sapiens cDNA 290

453467 A1535997 Hs 30089 ESTs 29 0

411794 AL118577 Hs75658 phosphorylase, glycogen, brain 28 9

421773 W69233 Hs 112457 ESTs 28 9

423621 BE002904 gb QV4-BN0090-070400-163-C07 BN0090 Homo sapi 28 8

408935 BE539706 Hs 285363 ESTs ^ 28 8

450847 NM 003155 Hs 25590 stanniocalcin 1 288

431243 U46455 Hs 252189 syndecan 4 (amphiglycan, ryudocaπ) 287

423225 AA852604 Hs 125359 Thy-1 cell surface antigen 287

433469 F12741 gb HSC3DG061 normalized infant brain cDNA Homo 287

405783 predicted exon 287

417308 H60720 Hs 81892 KIAA0101 gene product 287

400749 predicted exon 287

413442 BE140643 gb RC0-HT0015-310599 016 HT0015 Homo sapiens c 286

404828 predicted exon 286

407453 AJ132087 gb Homo sapiens mRNA for axonemal dynein heavy ch 28 6

418529 AW005695 Hs 250897 TRK-fused gene (NOTE non-standard symbol and πam 28 6

413787 AI352558 Hs 75544 tyrosine 3-monooxygenase/tryptophan 5-monooxygenas 285

450690 AA296696 Hs 25334 FXYD domain-containing ion transport regulator 5 285

402430 predicted exon 284

413929 BE501689 Hs 75617 collagen, type IV, alpha 2 282

423803 NM.005709 Hs 132945 PDZ-73 protein 282

406086 predicted exon 282

416585 X54162 Hs 79386 leiomodin 1 (smooth muscle) 282

417055 N39489 Hs7258 Homo sapiens cDNA FU22021 fis, clone HEP08253 28 1

449184 AW296295 Hs 196491 ESTs 28 1

446542 NM 004281 Hs 15259 BCL2-assocιated athanogene 3 28 1

412793 AW997986 gb RC1-BN0056-230200-021-e11 BN0056 Homo sapie 28 0

452818 W21909 Hs8372 ubiquinol-cytochrome c reductase (64kD) subunit 280

402869 predicted exon 279

436810 AA353044 Hs 5321 ARP3 (actin related protein 3, yeast) homolog 279

402075 predicted exon 279

410480 R97457 Hs 63984 cadheπn 13, H-cadheπn (heart) 278

406690 M29540 Hs 220529 carcinoembryonic antigen-related cell adhesion molecul 278

439766 AB033492 Hs 301241 Homo sapiens mRNA, cDNA DKFZp586A0424 (from 277

424482 BE268621 Hs 149155 voltage-dependent anion channel 1 276

420737 L08096 Hs 99899 tumor necrosis factor (ligand) superfamily, member 7 276

414663 BE396326 gb 601289258F1 NIH.MGC.8 Homo sapiens cDNA c 276

409703 NM.006187 Hs 56009 2'-5'olιgoadenylate synthetase 3 276

446108 AL036596 Hs 102773 ESTs 275

428144 BE269243 Hs 182625 VAMP (vesicle-associated membrane proteιn)-assocιate 275

445688 AI248205 Hs 153244 ESTs 275

405411 predicted exon 275

410275 U85658 Hs 61796 transcπption factor AP-2 gamma (activating enhaπcer-b 275

424675 NM 005512 Hs 151641 glycoprotein A repetitions predominant 273

450455 AL117424 Hs 25035 chloπde intracellular channel 4 273

414855 AA156986 Hs 104640 HIV-1 mducer of short transcπpts binding protein 272

433578 BE336886 Hs 3416 adipose differentiation related protein 272

401994 predicted exon 272

445033 AV652402 Hs 155145 ESTs 272

402277 predicted exon 27 1

428106 BE620016 Hs 182470 PTD010 protein 27 1

448625 AW970786 Hs 178470 Homo sapiens cDNA FU22662 fis, clone HSI08080 27 1

422587 AI879352 Hs 118625 hexokmase 1 270

457204 BE264152 Hs 221994 ESTs 27 0

444094 AI695764 Hs 202394 ESTs 270

414053 BE391635 Hs75725 transgelm 2 269

430511 BE018156 Hs 2575 calpaiπ 1 , (mu/l) large subunit 269

434039 L32977 Hs3712 Ubiquinot-cytochrome c reductase, Rieske iron sulfur po 269

424939 AK000059 Hs 153881 Homo sapiens NY-REN 62 antigen mRNA, partial eds 269

414539 BE379046 gb 601236646F1 NIH.MGC.44 Homo sapiens cDNA 269

404675 predicted exon 268

401597 AA172106 Hs 110950 Rag C protein 268

401405 predicted exon 268

411541 W03940 gb za62b02 r1 Soares fetal liver spleen 1 NFLS Homo sa 268 412025 AI827451 Hs 24143 ESTs 267

414276 BE297862 gb 601174780F1 NIH.MGC 17 Homo sapiens cDNA 267

444065 AW449415 Hs 10260 Homo sapiens cDNA FU11341 fis, clone PLACE1010 267

447981 R53772 Hs 8929 hypothetical protein FU11362 267

410677 NM.003278 Hs 65424 tetranectin (plasmmogen-bmding protein) 265

400982 predicted exon 265

452933 AW391423 Hs 288555 Homo sapiens cDNA FLJ22425 fis, clone HRC08686 265

407233 X16354 Hs 50964 carcinoembryonic antigen related cell adhesion molecul 264

430127 AA219498 Hs 233952 proteasome (prosome, macropain) subunit, alpha type, 7 263

448218 AI188489 gb qd09b12 x1 Soares_placenta_8to9weeks_2NbHP8to 263

413511 AI627178 Hs 75412 Arginine-πch protein 262

459511 AI142379 gb qg64c01 r1 Soares.testis.NHT Homo sapiens cDNA 262

410668 BE379794 Hs 65403 hypothetical protein 262

458662 AI823410 Hs 169149 karyopheπn alpha 1 (importm alpha 5) 262

451219 AA054209 Hs 167904 ESTs 262

448939 BE267795 Hs 22595 hypothetical protein FU10637 262

400800 Y10262 Hs 46925 eyes absent (Drosophila) homolog 3 262

446342 BE298665 Hs 14846 Homo sapiens mRN A, cDNA DKFZp564D016 (from c 262

421177 AW070211 Hs 102415 Homo sapiens mRNA, cDNA DKFZp586N0121 (from 26 1

433848 AF095719 Hs 93764 carboxypeptιdaseA3 26 1

448497 BE613269 Hs 21893 ESTs, Weakly similar to glycerol 3-phosphate permease 26 1

415279 F04237 Hs 1447 glial fibπllary acidic protein 260

419323 AI092379 Hs 135275 ESTs 260

430265 L36033 Hs 237356 stromal cell-deπved factor 1 259

437679 NM.014214 Hs 5753 ιπosιtol(myo):J(or 4)-monophosphatase 2 259

425535 AB007937 Hs 158287 KIAA0468 gene product 258

412923 AA179922 Hs 75056 adaptor-related protein complex 3, delta 1 subunit 258

447980 AI703397 Hs 202355 ESTs 258

419118 AA234223 Hs 139204 ESTs 258

421224 AW402154 Hs 125812 ESTs 258

414890 BE281095 Hs 77573 undine phosphorylase 258

447330 BE279949 Hs 18141 ladiniπ 1 257

405610 predicted exon 257

447604 AW089933 Hs 293674 ESTs 257

445677 H96577 Hs 6838 ras homolog gene family, member E 257

456088 BE177320 Hs 156148 Homo sapiens cDNA FLJ23082 fis, clone LNG06451 257

417120 N79687 Hs 46616 ESTs 256

405194 predicted exon 256

410687 U24389 Hs 65436 lysyl oxidase like 1 256

421888 AA299780 Hs 121036 ESTs 256

420459 AF016045 Hs 97905 ovo (Drosophila) homolog like 1 255

416323 N72630 Hs 33981 Homo sapiens genomic DNA, chromosome 21q, section 255

446292 AF081497 Hs 279682 Rh type C glycoprotein 255

416274 AW160404 Hs 79126 guanine nucleotide binding protein 10 255

430028 BE564110 Hs 227750 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 255

438450 AI050866 Hs 65853 nodal, mouse, homolog 255

400215 predicted exon 254

430014 H59354 Hs 182485 actmin, alpha 4 254

453582 AW854339 Hs 33476 hypothetical protein FLJ 11937 254

405867 predicted exon 254

459170 AI905518 gb RC-BT091-210199-098 BT091 Homo sapiens cDNA 254

407944 R34008 Hs 239727 desmocollin 2 254

415748 D90086 Hs 979 pyruvate dehydrogenase ( poamide) beta 253

423287 H38340 gb yp70h07 r1 Soares adult brain N2b4HB55Y Homo s 253

450944 AA554989 Hs 209061 sudD (suppressor of bιmD6, Aspergillus nidulans) homo 253

432906 BE265489 Hs 3123 lethal giant larvae (Drosophila) homolog 2 253

400104 predicted exon 253

449019 AI949095 Hs 67776 ESTs, Weakly similar to ALU7.HUMAN ALU SUBFA 253

406897 M57417 gb Homo sapiens mucm (muciπ) mRNA, partial eds 253

402639 predicted exon 253

447147 AA910353 Hs 292815 ESTs 253

453379 AA035261 Hs 61753 ESTs 253

414217 AI309298 Hs 279898 Homo sapiens cDNA FU23165 fis, clone LNG09846 253

430223 NM.002514 Hs 235935 nephroblastoma overexpressed gene 253

406685 M18728 gb Human nonspecific crossreacting antigen mRNA, co 253

444747 AW450407 Hs 257291 ESTs, Weakly similar to PSS8.HUMAN PROSTASIN 252

417883 R22519 Hs 23398 ESTs 252

430235 BE268048 Hs 236494 RAB10, member RAS oncogene family 252

459001 AI761313 Hs 204605 ESTs 252

434368 AW519020 Hs 212640 Homo sapiens cDNA FLJ13265 fis, clone OVARC1000 252

415917 Z43912 gb HSC10A111 normalized infant brain cDNA Homo 252

444409 AI792140 Hs 49265 ESTs 252

428578 BE391797 Hs 82148 hypothetical protein 25 1

433417 AA587773 Hs 136494 ESTs 25 1

426372 BE304680 Hs 169531 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21 25 1

402131 predicted exon 251

450545 AW135582 Hs 201767 ESTs 250

434162 AI221214 Hs 116136 ESTs 250

406571 predicted exon 249

427600 AW630918 Hs 179774 proteasome (prosome, macropain) activator subunit 2 (P 249

409402 AF208234 Hs 695 cystatin B (stefin B) 249

400135 predicted exon 249

428403 AI393048 Hs 239894 leucine πch repeat (in FUI) interacting protein 1 249

403223 predicted exon 248 435236 T03890 Hs 157208 ESTs, Highly similar to Arx homeoprotein [M musculu 248

457439 AW410408 Hs 271167 L-pipecoIic acid oxidase 248

448667 Z78394 Hs 4896 Homo sapiens cDNA FU22046 fis, clone HEP09276 248

440605 Z40094 Hs 185698 ESTs 248

426724 AA383623 Hs 293616 ESTs 248

403359 predicted exon 247

442826 AI018777 Hs 131241 ESTs 247

411503 AW190338 Hs 28029 puπnergic receptor P2X, ligand-gated ion channel, 4 246

414540 BE379050 gb 601236655F1 NIH.MGC.44 Homo sapiens cDNA 246

421595 AB014520 Hs 105958 Homo sapiens cDNA FU22735 fis, clone HUV00180 2 5

438802 AA825976 Hs 136954 ESTs 245

400491 H25530 Hs 50868 solute earner family 22 (organic cation transporter), me 245

418994 AA296520 Hs 89546 selectin E (endothelial adhesion molecule 1) 245

426383 BE537380 gb 601064570F1 NIH MGC 10 Homo sapiens cDNA 244

418408 AA219321 Hs 173294 ESTs 244

416186 W87575 Hs 269177 ESTs 244

416908 AA333990 Hs 80424 coagulation factor XIII, A1 polypeptide 244

453857 AL080235 Hs 35861 DKFZP586E1621 protein 244

439706 AW872527 Hs 59761 ESTs 244

441619 NM.014056 Hs 7917 DKFZP564K247 protein 244

417198 F11533 Hs 81634 ATP synthase, H+ transporting, mitochondπal F0 comp 243

433662 W07162 Hs 150826 CATX-8 protein 243

453986 M13232 Hs 36989 coagulation factor VII (serum prothrombin conversion a 243

457123 AA770021 Hs 16332 ESTs 243

433864 AA931550 Hs 192785 ESTs 243

409865 AW502208 gb UI-HF-BROp-aju-e-09-O-UI r1 NIH.MGC.52 Horn 243

448175 BE296174 Hs 225160 Homo sapiens cDNA FLJ13102 fis, clone NT2RP3002 243

406277 predicted exon 243

451957 AI796320 Hs 10299 Homo sapiens cDNA FLJ13545 fis, clone PLACE1006 243

408802 AL048269 Hs 288544 Homo sapiens cDNA FU20882 fis, clone ADKA0320 242

401757 predicted exon 242

444751 AI207406 Hs 11866 hypothetical protein PR01197 242

408647 AW245831 gb 2822937 δpπme NIH.MGC.7 Homo sapiens cDNA 242

418870 AF147204 Hs 89414 chemokiπe (C-X-C motif), receptor 4 (fusm) 242

436913 AA789074 Hs 187478 ESTs 242

434745 AW974445 Hs 185155 ESTs, Weakly similar to HuEMAP [H sapiens] 242

451743 AW074266 Hs 23071 ESTs 242

421853 AL117472 Hs 108924 DKFZP586P1422 protein 242

407926 AW956382 Hs 59771 ESTs 241

413973 BE279858 Hs 128417 Homo sapiens cDNA FLJ 14009 fis, clone Y79AA1002 241

439078 AF085936 gb Homo sapiens full length insert cDNA clone YR58F 24 1

401913 predicted exon 241

435138 BE314734 gb 601152976F1 NIH.MGCJ9 Homo sapiens cDNA 241

405311 predicted exon 240

413127 BE066529 Hs 83484 SRY (sex determining region Y)-box 4 240

430793 M83181 Hs 247940 5-hydroxytryptamιne (serotonin) receptor 1A 240

434445 AI349306 Hs 11782 ESTs 240

418166 AI754416 Hs 260024 Cdc42 effector protein 3 240

431971 BE274907 Hs 77385 myosin, light polypeptide 6, alkali, smooth muscle and n 239

401167 predicted exon 239

454163 AW175997 gb QV0-BT0078-190899 005 E02 BT0078 Homo sapi 239

403306 NM 006825 Hs 74368 transmembrane protein (63kD), endoplasmic reticulum/ 239

410627 AA181339 Hs 929 myosin, heavy polypeptide 7, cardiac muscle, beta 239

450796 NM 001988 Hs 25482 envoplakin 238

442199 BE277633 Hs 286027 etoposide-mduced mRNA 238

402699 predicted exon 238

426143 BE379836 Hs 167106 proteasome (prosome, macropain) subunit, alpha type, 3 238

437592 NM 003851 Hs 5710 cellular repressor of E1 A-stimulated genes 238

433598 AI762836 Hs 271433 ESTs, Moderately similar to ALU2.HUMAN ALU SU 238

401088 predicted exon 238

445924 AI264671 Hs 164166 ESTs 238

420902 AA742277 gb πy28e09 s1 NCI_CGAP_GCB1 Homo sapiens cDN 238

426369 AF134157 Hs 169487 Kreisler (mouse) maf-related leucine zipper homolog 238

458698 AW452189 Hs 257528 ESTs 237

422048 NM 012445 Hs 288126 spondin 2, extracellular matπx protein 237

413460 R61610 Hs 21527 ESTs, Weakly similar to KIAA0918 protein [H sapiens 236

401575 predicted exon 236

431822 AA516049 gb ng65d01 s1 NCI CGAP Up2 Homo sapiens cDNA 236

427276 AA400269 Hs 49598 ESTs 236

417069 AA442192 Hs 81097 cytochrome c oxidase subunit VIII 235

400161 predicted exon 235

417190 NM 001359 Hs 81548 2,4-dιeπoyl CoA reductase 1, mitochondπal 235

443667 AI129066 Hs 135457 ESTs 235

413544 BE147225 gb PM2-HT0225-031299-003-f11 HT0225 Homo sapie 235

400685 predicted exon 235

422090 W05345 Hs 293884 ESTs 234

432517 AF275816 Hs 283096 PR domain containing 9 234

405307 predicted exon 234

416328 H48389 Hs 268886 ESTs 234

427174 AA398848 Hs 97541 ESTs 234

426148 AI751071 Hs 167135 Homo sapiens cDNA FU10728 fis, clone NT2RP3001 233

452544 AW851888 gb QV0-CT0225-131099-034-d05 CT0225 Homo sapie 233

404890 predicted exon 233

408725 AA131539 Hs 15669 ESTs 233 428362 AA426555 Hs.169333 ESTs 23.3

425349 AA425234 Hs.79886 ribose 5-phosphate isomerase A (ribose 5-phosphate ep 23.3

422440 NM 004812 Hs.116724 aldo-keto reductase family 1, member B11 (aldose redu 23.3

410962 BE273749 Hs.752 FK506-binding protein 1A (12kD) 23.2

411796 AA807197 Hs.6918 ESTs 23.2

458954 AW379075 Hs.141742 Homo sapiens cDNA FU12211 fis, clone MAMMA10 23.2

408896 AI610447 Hs.48778 niban protein 23.2

457024 AA397546 Hs.119151 ESTs 23.2

414591 AI888490 Hs.55902 ESTs 23.2

437846 AA773866 Hs.244569 ESTs 23.2

401220 predicted exon 23.1

421747 AI816224 Hs.107747 DKFZP566C243 protein 23.1

452950 AA428123 Hs.7745 17kD fetal brain protein 23.1

414327 BE408145 Hs.185254 ESTs, Moderately similar to NAC-1 protein [R.norvegic 23.1

405256 predicted exon 23.1

452416 AA026115 Hs.114777 ESTs 23.1

440684 AI253123 Hs.127356 ESTs, Highly similar to NEST HUMAN NESTI [H.sap 23.1

445603 H08345 Hs.106234 ESTs 23.1

436306 AA805939 Hs.117927 ESTs 23.1

434867 AF159442 Hs.103382 phospholipid scramblase 3 23.0

404727 predicted exon 23.0

407317 AI204033 Hs.271461 ESTs, Weakly similar to ALU5.HUMAN ALU SUBFA 23.0

405580 predicted exon 23.0

437898 W81260 Hs.43410 ESTs 22.9

448781 AW243419 Hs.254048 ESTs 22.9

457297 AW968188 Hs.290999 ESTs 22.9

405545 predicted exon 22.9

431562 AI884334 Hs.11637 ESTs 22.9

440703 AL137663 Hs.7378 Homo sapiens mRNA; cDNA DKFZp434G227 (from c 22.9

439848 AW979249 gb:EST391359 MAGE resequences, MAGP Homo sap 22.9

418149 AA811473 Hs.291877 ESTs 22.9

439332 AW842747 Hs.293314 ESTs, Highly similar to unnamed protein product [H.sa 22.8

401566 predicted exon 22.8

425078 NM 002599 Hs.154437 phosphodiesterase 2A, cGMP-stimulated 22.8

406684 X16354 Hs.50964 carcinoembryonic antigen-related cell adhesion molecul 22.8

421651 AW860612 Hs.283586 ESTs 22.8

421064 AI245432 Hs.101382 tumor necrosis factor, alpha-induced protein 2 22.8

441249 AA971585 Hs.166250 ESTs 22.8

457624 AA809159 Hs.287581 Homo sapiens cDNA FU13544 fis, clone PLACE1006 22.8

407395 AF005082 gb:Homo sapiens skin-specific protein (xp33) mRNA, p 22.8

459006 AW298631 Hs.27721 hypothetical protein FLJ20353 22.8

436827 H72187 Hs.5322 guanine nucleotide binding protein (G protein), gamma 22.7

418174 L20688 Hs.83656 Rho GDP dissociation inhibitor (GDI) beta 22.7

418307 U70867 Hs.83974 solute carrier family 21 (prostaglandin transporter), mem 22.7

456035 N54956 Hs.271726 ESTs 22.7

457867 AA045767 Hs.5300 bladder cancer associated protein 22.7

440401 AI126341 Hs.143887 ESTs 22.7

400126 predicted exon 22.7

414931 AK000342 Hs.77646 Homo sapiens mRNA; cDNA DKFZp761M0223 (from 22.7

406719 AI832962 Hs.169476 glyceraldehyde-3-phosphate dehydrogenase 22.6

439675 W95357 Hs.138860 Rho GTPase activating protein 1 22.6

456058 N94587 Hs.55063 ESTs 22.6

441926 AI015051 Hs.130953 ESTs 22.6

428423 AU076517 Hs.184276 solute carrier family 9 (sodium/hydrogen exchanger), is 22.6

438518 BE561958 Hs.285823 immunoglobulin heavy constant mu 22.6

420674 NM 000055 Hs.1327 butyrylcholinesterase 22.6

422160 AW582898 gb:ia07e04.y1 Human Pancreatic Islets Homo sapiens c 22.5

412408 D51103 Hs.73851 ATP synthase, H+ transporting, mitochondrial F0 comp 22.5

400964 predicted exon 22.5

434360 AW015415 Hs.127780 ESTs 22.5

427977 AW630727 Hs.181307 H3 histone, family 3A 22.4

450339 AI693281 Hs.54547 ESTs 22.4

424059 AW451266 Hs.107418 ESTs 22.4

414626 BE410589 gb:601303308F1 NIH.MGC.21 Homo sapiens cDNA 22.4

401991 predicted exon 22.4

419741 NM 007019 Hs.93002 ubiquitin earner protein E2-C 22.3

457952 U25750 Hs.210783 Human chromosome 17q21 mRNA clone 1046:1-1 22.3

422597 BE245909 Hs.118634 ATP-binding cassette, sub-family B (MDR TAP), mem 22.3

429504 X99133 Hs.204238 lipocalin 2 (oncogene 24p3) 22.3

447306 AI373163 Hs.170333 ESTs 22.3

424966 AU077312 Hs.153985 solute canier family 7 (cationic amino acid transporter, 22.3

422739 H20106 Hs.119591 adaptor-related protein complex 2, sigma 1 subunit 22.2

432504 AL121015 Hs.277704 oxygen regulated protein (150kD) 22.2

423804 AW403448 Hs.1706 interferan-stimulated transcription factor 3, gamma (48k 22.2

404683 AI924294 Hs.173259 uncharacterized bone marrow protein BM033 22.2

441624 AF220191 Hs.179666 uncharacterized hypothalamus protein HSMNP1 22.2

425751 T19239 Hs.1940 crystallin, alpha B 22.2

452976 R44214 Hs.101189 ESTs 22.2

414642 AA150350 gb:zl03h01.r1 Soares _pregnant_uterus_NbHPU Homo 22.2

437452 AL390127 Hs.7104 Homo sapiens mRNA; cDNA DKFZp761P06121 (from 22.2

417426 NM.002291 Hs.82124 laminin, beta 1 22.2

414774 X02419 Hs.77274 plasminogen activator, urakinase 22.1

424631 AA688021 Hs.179808 ESTs 22.1

413967 AW204431 Hs.117853 ESTs 22.1 400174 predicted exon 221

431837 T79326 Hs 298262 ESTs, Weakly similarto dJ88J8 1 [H sapiens] 221

401628 predicted exon 22 1

418374 AJ011916 Hs 84359 hypothetical protein 220

428297 X82494 Hs 198862 fibulm 2 220

403508 predicted exon 220

432638 AI017717 Hs 126525 chromosome 21 open reading frame 15 220

407382 AA503620 gb ne49b08 s1 NCI_CGAP_Co3 Homo sapiens cDNA 220

411492 T46848 Hs 70337 immunoglobulin superfamily, member 4 220

420185 AL044056 Hs 158047 ESTs 220

409545 BE296182 gb 601177324F1 NIH MGC 17 Homo sapiens cDNA 220

426662 AA879474 Hs 122710 ESTs 220

424247 X14008 Hs 234734 lysozyme (renal amyloidosis) 220

443062 N77999 Hs 8963 Homo sapiens mRNA full length insert cDNA clone EU 21 9

422447 AA310711 Hs 124340 ESTs 21 9

421574 AJ000152 Hs 105924 defensm, beta 2 21 9

435302 AI076259 Hs 190337 ESTs 21 9

414527 BE241739 Hs 76359 catalase 21 9

441436 AW137772 Hs 185980 ESTs 21 9

454178 AW177274 gb CM2-CT0128-230899 005-a02 CT0128 Homo sapie 21 8

448838 BE614761 gb 601281335F1 NIH_MGC_39 Homo sapiens cDNA 21 8

427889 AI400968 Hs 181046 dual specificity phosphatase 3 (vaccinia virus phosphat 21 8

441114 AA917466 Hs 126600 ESTs 21 8

451831 NMJ01674 Hs 460 activating transcπption factor 3 21 8

405600 predicted exon 21 8

446981 AI652743 Hs 197497 ESTs 21 8

432839 AA579465 Hs 287332 ESTs 21 8

405208 predicted exon 21 8

435025 T08990 Hs 4742 anchor attachment protein 1 (Gaa1 p, yeast) homolog 21 7

413976 BE295452 Hs 75655 procollagen-proline, 2-oxoglutarate 4-dιoxygenase (pro 21 7

423515 AA327017 Hs 162204 ESTs 21 7

452329 N36626 Hs 29106 mitogeπ activated protein kinase phosphatase x 21 7

423050 AA320946 gb EST23529 Adipose tissue, brown Homo sapiens cD 21 7

413679 BE156765 gb RC1-HT0370-120100-012-C09 HT0370 Homo sapie 21 7

442166 AW845280 Hs 204723 ESTs 21 6

445585 AI243836 Hs 147066 ESTs 21 6

406160 predicted exon 21 6

433025 AA374743 Hs 279920 tyrosine 3-monooxygenase/tryptophaπ 5-monooxygenas 21 6

446598 AW250546 gb 28217745pπme NIH MGC 7 Homo sapiens cDNA 21 6

434493 AA635305 Hs 121574 ESTs 21 6

429582 AI569068 Hs 22247 ESTs 21 6

403796 predicted exon 21 6

405028 predicted exon 21 6

426597 AA382250 Hs 145601 ESTs 21 6

437308 AA749417 Hs 292353 ESTs 21 6

447384 AI377221 Hs 40528 ESTs 21 6

429060 AW139155 Hs 194995 hypothetical protein DKFZp434O0320 21 6

437068 AA743643 Hs 291427 ESTs 21 6

418509 AB028624 Hs 85539 ATP synthase, H+ transporting, mitochondnal FO comp 21 5

432999 BE294029 Hs 279903 Ras homolog enπched in brain 2 21 5

407663 NM.016429 Hs 37482 COPZ2 for nondathnn coat protein zeta COP 21 5

446627 A1973016 Hs 15725 hypothetical protein SBBI48 21 5

413605 BE152644 gb CM1-HT0329-250200-128-f09 HT0329 Homo sapie 21 5

427286 AW732802 Hs 2132 epidermal growth factor receptor pathway substrate 8 21 5

405226 predicted exon 21 4

402570 predicted exon 21 4

457960 AA771881 Hs 298149 ESTs 21 4

400684 predicted exon 21 4

425943 H46986 Hs 31861 ESTs 21 4

434240 AF119912 Hs 258119 hypothetical protein PRO3073 21 4

448376 AI494332 Hs 196963 ESTs 21 4

408089 H59799 Hs 42644 thioredoxm-like 21 4

400304 AF005082 Hs 113261 Homo sapiens skin specific protein (xp33) mRNA, part 21 4

412652 AI801777 Hs 6774 ESTs 21 4

428373 AI751656 Hs 183986 poliovirus receptor-related 2 (herpesviras entry mediato 21 3

416138 C18946 Hs 79026 myeloid leukemia factor 2 21 3

425184 BE278288 Hs 155048 Lutheran blood group (Auberger b antigen included) 21 3

411028 AW813703 gb RC3-ST0197-130100-014-h09 ST0197 Homo sapien 21 3

417438 Z43989 Hs 82141 Human clone 23612 mRNA sequence 21 3

417534 NM 004998 Hs 82251 myosin IC 21 3

427767 AI879283 Hs 180714 cytochrome c oxidase subunit Via polypeptide 1 21 2

433300 AA582307 gb nn49d09 s1 NCI.CGAP.Kid6 Homo sapiens cDNA 21 2

452061 AI074259 Hs 469 succinate dehydrogenase complex, subunit A, flavoprat 21 2

411939 AI365585 Hs 146246 ESTs 21 2

435060 AI422719 Hs 233349 ESTs, Weakly similar to fork head like protein [H sapie 21 2

432412 AI470549 Hs 162201 ESTs 21 2

407491 S82769 gb GABAA receptor gamma 3 subunit [human, fetal bra 21 2

418960 NM 004494 Hs 89525 hepatoma-deπved growth factor (high mobility group p 21 1

426254 BE018103 Hs 168541 Homo sapiens mRNA full length insert cDNA clone EU 21 1

458188 AW297226 Hs 137840 ESTs, Moderately similarto SIX1.HUMAN HOMEOB 21 1

406215 predicted exon 21 1

425461 AK000602 Hs 157938 hypothetical protein FLJ20595 21 1

448296 BE622756 Hs 10949 Homo sapiens cDNA FU14162 fis, clone NT2RM4002 21 1

409415 AA579258 Hs 6083 Homo sapiens cDNA FU21028 fis, clone CAE07155 21 1 408546 W49512 Hs 46348 bradykinin receptor B1 21 1

450008 H52970 Hs 36688 WAP four-disulfide core domain 1 21 1

430998 AF128847 Hs 204038 indolethylamine N-methyltransferase 21 1

438901 AF085834 Hs 29036 ESTs 21 1

440500 AA972165 Hs 150308 ESTs 21 1

413101 BE065215 gb RC1-BT0314-310300-015-f01 BT0314 Homo sapie 21 1

447452 BE618258 Hs 102480 ESTs 21 1

412446 AI768015 Hs 92127 ESTs 21 1

418975 T75496 Hs 296980 ESTs 21 0

454961 AW847807 gb IL3-CT0213-190200-040-E12 CT0213 Homo sapien 21 0

401072 predicted exon 21 0

401204 predicted exon 21 0

433626 AF078859 Hs 86347 hypothetical protein 21 0

418047 R37633 Hs 4847 ESTs 21 0

443380 AI792478 Hs 135377 ESTs 21 0

427424 AA402453 Hs 113011 ESTs 21 0

433412 AV653729 Hs 8185 CGl-44 protein, sulfide dehydrogenase like (yeast) 21 0

422599 BE387202 Hs 118638 non-metastatic cells 1, protein (NM23A) expressed in 209

435656 R93409 Hs 120759 ESTs 209

413745 AW247252 Hs 75514 nucleoside phosphorylase 209

418874 T60872 gb yb72h11 s1 Stratagene ovary (937217) Homo sapien 209

452574 AF127481 Hs 35093 lymphoid blast cπsis oncogene 209

400332 S66407 Hs 248032 FLT4 209

402421 predicted exon 209

427138 N77624 Hs 173717 phosphatidic acid phosphatase type 2B 209

432038 AA524746 Hs 162110 ESTs 208

423711 AF059194 Hs 131953 v-maf musculoaponeurotic fibrosarcoma (avian) oncoge 208

402297 predicted exon 208

405133 predicted exon 208

436661 AI125270 Hs 128069 ESTs, Weakly similar to similar to collagen [C elegans] 208

437836 BE269291 Hs 292458 ESTs 208

437329 AA811977 Hs 291761 ESTs 208

445830 H10451 Hs 42656 Homo sapiens cDNA FLJ12667 fis, clone NT2RM4002 208

406824 AW515961 Hs 84298 CD74 antigen (mvaπant polypeptide of major histocom 207

421271 AW170057 Hs 133179 ESTs 20

400256 predicted exon 207

414028 AA782576 Hs 4944 Homo sapiens cDNA FLJ12783 fis, clone NT2RP2001 207

456728 AL120077 Hs 122967 kelch (Drosophιla)-lιke 2 (Mayven) 207

417707 AL035786 Hs 82425 actin related protein 2/3 complex, subunit 5 (16 kD) 207

438713 H16902 Hs 6749 ESTs 207

450306 AL080080 Hs 24766 DKFZP564E1962 protein 207

438898 AI819863 Hs 106243 ESTs 207

403273 predicted exon 207

414605 BE390440 gb 601283601F1 NIH.MGC.44 Homo sapiens cDNA 207

401283 predicted exon 207

403703 predicted exon 206

416969 AI815443 Hs 283404 organic cation transporter 206

442400 AW381148 Hs 3593 ESTs 206

447563 BE536115 Hs 160983 ESTs 205

419754 H52299 Hs 75243 bromodomain-containing 2 205

408204 AA454501 Hs 43666 protein tyrosine phosphatase type IVA, member 3 205

450507 AW295603 Hs 250891 ESTs 205

429612 AF062649 Hs 252587 pituitary tumor-transforming 1 205

413758 BE162391 gb PM2-HT0451-090100-002-f04 HT0451 Homo sapie 205

432140 AK000404 Hs 272688 hypothetical protein FU20397 205

400642 predicted exon 204

431582 F07136 Hs 261828 G protein-coupled receptor kinase 7 204

442724 AA355525 Hs 159604 cysteinyl-tRNA synthetase 204

417861 AA334551 Hs 82767 sperm specific antigen 2 204

402948 predicted exon 204

411004 AW813242 gb MR3-ST0191-020200-207-g10 ST0191 Homo sapie 204

435478 AA682622 gb zj20f09 s1 Soares etalJιver_spleeπ_1NFLS_S1 Ho 204

447955 BE544271 Hs 288380 Homo sapiens cDNA FLJ22795 fis, clone KAIA2543 203

433592 NM 004642 Hs 3436 deleted in oral cancer (mouse, homolog) 1 203

420865 N73241 Hs 100001 solute earner family 17 (sodium phosphate), member 1 203

449482 AI784266 Hs 28774 ESTs 203

400807 predicted exon 203

419942 U25138 Hs 83841 potassium large conductance calcium-activated channel 203

420783 AI659838 Hs 99923 lectin, galactoside-binding, soluble, 7 (galectm 7) 203

402986 BE244588 Hs 6456 chaperonin containing TCP1, subunit 2 (beta) 203

451375 AI792066 Hs 283902 Homo sapiens BAC clone RP11-481 J13 from 2 203

453586 AA248089 Hs 50841 ESTs, Weakly similar to tuftelm [M musculus] 203

433090 AI720050 Hs 45362 immortalization upregulated protein 203

425053 AF046024 Hs 154320 ubiqurtin-activating enzyme E1C (homologous to yeast 203

412802 U41518 Hs 74602 aquapoππ 1 (channel-forming integral protein, 28kD) 203

409738 BE222975 Hs 56205 insulin induced gene 1 203

428245 AF151048 Hs 183180 hypothetical protein 202

412582 BE270631 Hs 74077 proteasome (prosome, macropain) subunit, alpha type, 6 202

406207 predicted exon 202

400931 predicted exon 202

410709 AL122109 Hs 65735 Homo sapiens mRNA, cDNA DKFZp434M1827 (from 202

428438 NM.001955 Hs 2271 eπdothelm 1 202

446918 AL135125 Hs 13913 KIAA1577 protein 202

417821 BE245149 Hs 82643 protein tyrosine kinase 9 202 429113 D28235 Hs.196384 prostaglandin-endoperaxide synthase 2 (prostaglandin G 20.2

414511 AA148725 Hs.12969 hypothetical protein 20.2

451546 AF051782 Hs.26584 Homo sapiens clone CDABP0038 mRNA sequence 20.1

441899 AI372588 Hs.8022 TU3A protein 20.1

425811 AL039104 Hs.159557 karyopherin alpha 2 (RAG cohort 1 , importin alpha 1) 20.1

411014 AW816072 gb:MR3-ST0220-070100-021-h07 ST0220 Homo sapie 20.1

451400 BE160479 gb:QV1-HT0413-210200-081 -g05 HT0413 Homo sapi 20.1

459247 N46243 Hs.110373 ESTs 20.1

441633 AW958544 Hs.112242 ESTs 20.1

427466 AA523543 Hs.7678 cellular retinoic acid-binding protein 1 20.0

406893 M22406 gb:Human intestinal mucin mRNA, partial eds, clone SM 20.0

406268 predicted exon 20.0

403348 predicted exon 20.0

400970 predicted exon 20.0

414045 NM.002951 Hs.75722 ribophorin II 20.0

427169 AA398823 Hs.97549 EST 20.0

405586 predicted exon 20.0

445834 AI913290 Hs.145532 ESTs, Weakly similar to Gag polyprotein [M.musculus 20.0

422525 AA758797 Hs.192807 ESTs 20.0

425383 D83407 Hs.156007 Down syndrome critical region gene 1-like 1 20.0

454590 AW809762 Hs.222056 Homo sapiens cDNA FU11572 fis, clone HEMBA100 20.0

411529 AA430348 Hs.288837 Homo sapiens cDNA FU12927 fis, clone NT2RP2004 20.0

425397 J04088 Hs.156346 topoisomerase (DNA) II alpha (170kD) 20.0

403234 predicted exon 19.9

427267 AI201185 Hs.119164 ESTs 19.9

400203 predicted exon 19.9

449296 AL137257 Hs.23458 Homo sapiens mRNA; cDNA DKFZp434C1613 (from 19.9

406704 M21665 Hs.929 myosin, heavy polypeptide 7, cardiac muscle, beta 19.9

423083 AA321774 Hs.10941 ESTs, Weakly similar to IPP1.HUMAN PROTEIN PH 19.9

422112 BE540240 Hs.111783 Lsm1 protein 19.9

413282 BE078159 gb:CM0-BT0615-140200-175-e06 BT0615 Homo sapie 19.9

453702 AA037637 Hs.42128 ESTs 19.9

403065 predicted exon 19.9

440633 AI140686 Hs.263320 ESTs 19.9

456994 AA383623 Hs.293616 ESTs 19.9

458260 R41782 Hs.22279 ESTs 19.9

452388 BE019696 Hs.29287 retinoblastoma-binding protein 8 19.9

422278 AF072873 Hs.114218 frizzled (Drosophila) homolog 6 19.9

441989 AA306207 Hs.286241 Homo sapiens cDNA: FLJ22698 fis, clone HSU 2044 19.9

418758 AW959311 Hs.87019 ESTs 19.9

406646 M33600 Hs.180255 major histocompatibility complex, class II, DR beta 1 19.8

433053 BE301909 Hs.279952 glutathione S-transferase subunit 13 homolog 19.8

414194 BE175494 Hs.75811 N-acylsphingosine amidohydrolase (acid ceramidase) 19.8

452321 AW844498 Hs.289052 Homo sapiens LENG8 mRNA, variant C, partial sequen 19.8

449713 AW027025 Hs.239262 ESTs 19.8

458827 AW970786 Hs.178470 Homo sapiens cDNA: FLJ22662 fis, clone HSI08080 19.8

414092 Z14244 Hs.75752 cytochrome c oxidase subunit Vllb 19.8

441730 AI243276 Hs.149017 ESTs 19.8

420701 N42919 Hs.88630 ESTs, Weakly similar to AC007228 1 R316652 [H.sap 19.8

403642 predicted exon 19.8

408987 H85615 gb:yt03f11.r1 Soares retina N2b5HR Homo sapiens cD 19.8

446712 AW204789 Hs.209828 ESTs 19.8

403286 predicted exon 19.8

434439 AI022360 Hs.190583 ESTs 19.8

404067 predicted exon 19.7

455694 BE067300 gb:PM2-BT0349-161299-001-h10 BT0349 Homo sapie 19.7

403287 predicted exon 19.7

434633 AI189587 Hs.120915 ESTs 19.7

408199 AA132637 Hs.15396 ESTs 19.7

420080 M94065 Hs.94925 dihydrooratate dehydrogenase 19.7

408852 AW291435 Hs.254961 ESTs 19.7

403786 predicted exon 19.7

416839 H94900 Hs.17882 ESTs 19.7

434385 AA631946 Hs.259580 ESTs 19.7

446845 AI343645 Hs.156108 ESTs 19.7

425612 BE004257 gb:CMO-BN0103-180300-296-c04 BN0103 Homo sapi 19.7

402520 predicted exon 19.6

436098 R20597 Hs.9739 ESTs 19.6

438974 AF089816 Hs.6454 chromosome 19 open reading frame 3 19.6

447751 AA339541 Hs.24956 hypothetical protein FU22056 19.6

451310 AW250651 Hs.26213 ESTs, Moderately similar to dJ447F3.3 [H.sapiens] 19.6

435961 BE293127 Hs.283722 GTT1 protein 19.6

452937 BE410390 Hs.288940 five-span transmembrane protein M83 19.6

404850 predicted exon 19.6

438360 H74149 Hs.288193 hypothetical protein FU10375 19.6

436508 AW604381 Hs.121121 ESTs 19.6

430486 BE062109 Hs.241551 chloride channel, calcium activated, family member 2 19.6

407824 AA147884 Hs.9812 ESTs 19.6

406388 predicted exon 19.6

430204 AA618335 Hs.146137 ESTs, Weakly similar to putative [C.elegans] 19.5

457560 AI801934 Hs.163909 ESTs 19.5

429521 BE048708 Hs.50949 ESTs 19.5

429758 AW137722 Hs.246804 ESTs 19.5

441473 AA934995 Hs.184846 ESTs, Weakly similar to R28830 1 [Rsapiens] . 19.5 411724 AA770559 Hs 71618 polymerase (RNA) II (DNA directed) polypeptide L (7 195

450453 AA009883 Hs 50186 ESTs 195

419687 AI638859 Hs 227699 ESTs, Weakly similar to Yhr217cp [S cerevisiae] 195

442162 AW294966 Hs 150849 ESTs 195

435056 AW023337 Hs 5422 glycoprotein M6B 195

417412 X16896 Hs 82112 interleukin 1 receptor, type I 195

413825 BE299181 Hs 75564 CD151 antigen 194

422687 AW068823 Hs 119206 insulin like growth factor binding protein 7 194

435551 AF212365 Hs 5470 IL-17B receptor 194

440069 BE617892 Hs 6895 actin related protein 2/3 complex, subunit 3 (21 kD) 194

432277 AI669790 Hs 161825 ESTs 194

428044 AA093322 Hs 182225 RNA binding motif protein 3 194

456064 AA256213 Hs 72010 ESTs 194

424897 D63216 Hs 153684 fπzzled-related protein 194

424673 AA345051 Hs 294092 ESTs 194

403852 predicted exon 193

405699 predicted exon 193

433096 AU076803 Hs 282975 carboxylesterase 2 (intestine, liver) 193

400344 NM 012368 Hs 258574 olfactory receptor, family 2, subfamily C, member 1 193

417501 AL041219 Hs 82222 sema domain, immunoglobulin domain (lg), short basic 193

400449 predicted exon 193

453801 AL134751 Hs 23450 mRNA for FLJ00023 protein 193

435849 BE305242 Hs 112442 ESTs, Weakly similar to CLDE HUMAN CLAUDIN- 193

454181 AW177377 gb C 4-CT0129-190899-007-e09 CT0129 Homo sapie 193

414807 AI738616 Hs 77348 hydroxyprostaglandin dehydrogenase 15-(NAD) 193

406326 predicted exon 193

421921 H83363 Hs 109571 translocase of inner mitochondπal membrane 10 (yeast) 193

416700 AW498958 Hs 79572 cathepsin D (lysosomal aspartyl protease) 192

458857 AI627342 Hs 224601 ESTs 192

405501 predicted exon 192

416601 R08652 Hs 20205 hemoglobin, beta pseudogene 1 192

426600 NM 003378 Hs 171014 VGF nerve growth factor inducible 192

425590 AI954686 Hs 158321 beaded filament structural protein 2, phakinm 192

428151 AA422028 gb zv26g06 r1 Soares NhHMPu S1 Homo sapiens cDN 192

426420 BE383808 Hs 169829 KIAA1180 protein 192

414428 BE296906 Hs 182625 VAMP (vesicle-associated membrane proteιn)-assocιate 192

404601 predicted exon 192

403861 predicted exon 19 2

448363 BE174595 Hs 366 6 pyruvoyltetrahydropteπn synthase 192

406655 M21533 Hs 181244 major histocompatibility complex, class I, A 19 1

435372 AA809591 Hs 106486 ESTs, Highly similar to CIKG HUMAN VOLTAGE-G 19 1

413154 BE067870 gb RC0-BT0362 021299 031-b06 BT0362 Homo sapie 191

443021 AA368546 Hs 8904 Ig superfamily protein 191

412975 T70956 Hs 75106 clustenn (complement lysis inhibitor, SP-40,40, sulfated 191

412633 AF001691 Hs 74304 peπplakm 191

402071 predicted exon 19 1

410387 AI277367 Hs 47094 ESTs 19 1

423961 D13666 Hs 136348 osteoblast specific factor 2 (fasciclin l-like) 19 1

407032 U73799 gb Human dynactin mRNA, partial eds 190

404034 predicted exon 190

456534 X91195 Hs 100623 phospholipase C, beta 3, neighbor pseudogene 190

446599 Z97832 Hs 15476 differentially expressed in FDCP (mouse homolog) 6 190

426410 BE298446 Hs 180372 BCL2 like 1 190

419618 AA528295 gb nh26e06 s1 NCI CGAP Pr3 Homo sapiens cDNAc 190

457632 AW292151 Hs 112689 ESTs 190

417138 AA193646 Hs 65771 Homo sapiens chromosome 19, BAC CIT-HSPC.204F 190

417933 X02308 Hs 82962 thymidylate synthetase 190

458808 AW134832 Hs 246295 ESTs 190

415860 D56051 Hs 78888 diazepam binding inhibitor (GABA receptor modulator 189

440919 AW291274 Hs 262826 ESTs 189

423725 AJ403108 Hs 132127 hypothetical protein LOC57822 18 9

401747 predicted exon 189

454209 AW179083 gb MR4-ST0065-270899 006-A07 ST0065 Homo sapi 188

417661 T84155 Hs 15464 Homo sapiens cDNA FU21351 fis, clone COL02762 188

426499 C14937 Hs 11169 Gene 33/Mιg 6 18 8

404240 predicted exon 188

439718 AA307634 Hs 6650 vacuolar protein sorting 45B (yeast homolog) 188

401789 predicted exon 188

456952 AW445081 Hs 301469 ESTs 18 8

439739 AI199391 Hs 124464 ESTs 188

437974 T74445 Hs 5957 Homo sapiens clone 24416 mRNA sequence 188

427490 Z95152 Hs 178695 mitogen-activated protein kinase 13 188

443482 AW188093 Hs 250385 ESTs 188

411420 BE390652 gb 601286820F1 NIH MGC 44 Homo sapiens cDNA 188

435196 F35675 Hs 188128 ESTs, Moderately similar to ALUB.HUMAN «« ALU 18 8

417022 NM 014737 Hs 80905 Ras association (RalGDS/AF 6) domain family 2 18 8

413531 AL036958 Hs 75416 DAZ associated protein 2 187

428981 BE313077 Hs 93135 ESTs 187

421598 AW630942 Hs 106061 RD RNA-bindmg protein 187

443907 AU076484 Hs 9963 TYRO protein tyrosine kinase binding protein 187

406754 AA477223 Hs 75922 brain protein 13 187

400661 predicted exon 187

442638 AI088742 Hs 134713 ESTs 187

434169 AA883752 Hs 179724 ESTs 187 424126 AA335635 Hs 96917 ESTs 187

408473 BE259039 Hs 129953 Ewmg sarcoma breakpoint region 1 187

401962 predicted exon 187

447326 AW002252 Hs 201395 ESTs 187

459053 AI807052 Hs 210361 ESTs 187

403362 predicted exon 187

427697 T18997 Hs 180372 BCL2-lιke 1 187

402061 H83363 Hs 109571 franslocase of inner mitochondria! membrane 10 (yeast) 187

433785 BE044593 Hs 112704 ESTs 187

405423 predicted exon 186

429259 AA420450 Hs 292811 ESTs 18 6

444071 AI627808 Hs 110524 ESTs 18 6

410512 AA085603 Hs 250570 ESTs 18 6

440376 AI024452 Hs 236816 ESTs 18 6

457353 X65633 Hs 248144 melanocortin 2 receptor (adreπocorticotropic hormone) 186

432749 NM 014438 Hs 278909 lnterleukm-1 Superfamily e 186

415602 F12920 Hs 165575 ESTs 186

407891 AA486620 Hs 41135 endomucιn-2 186

455910 Z43712 gb HSC1JA121 normalized infant brain cDNA Homo s 186

426716 NM 006379 Hs 171921 sema domain, immunoglobulin domain (Ig), short basic 186

444246 H93281 Hs 10710 hypothetical protein FLJ20417 186

428125 AA393071 Hs 182579 leucine aminopeptidase 186

406457 predicted exon 185

446625 AI333070 Hs 156141 ESTs 185

423334 AK000906 Hs 127273 hypothetical protein FLJ 10044 185

423103 AA322029 gb EST24685t erebellum II Homo sapiens cDNA 5' en 185

443549 T89608 Hs 16601 ESTs 185

419299 AI311085 Hs 62406 Homo sapiens cDNA FLJ22573 fis, clone HSI02387 185

411942 AW877015 gb QV2-PT0010-250300-096-f 12 PT0010 Homo sapien 18 5

442440 BE464435 Hs 146180 ESTs, Weakly similarto non-receptor protein tyrosine k 18 5

454574 AW809109 gb MR4-ST0117-070100-027-a04 ST0117 Homo sapie 185

454377 AA076811 gb 7B03C12 Chromosome 7 Fetal Brain cDNA Library 185

422365 AF035537 Hs 115521 REV3 (yeast homolog) like, catalytic subunit of DNA p 185

421733 AL119671 Hs 1420 fibroblast growth factor receptor 3 (achondroplasia, tha 185

420603 AB042636 Hs 4775 junctophilin 3 184

401373 predicted exon 184

402292 predicted exon 184

444118 AA458542 Hs 10326 coatomer protein complex, subunit epsilon 184

408310 AW179023 gb PM3-ST0036-170899-001-e08 ST0036 Homo sapie 184

411236 AW833752 gb QV4-TT0008-130100 077-b07 TT0008 Homo sapie 184

431405 AI470895 Hs 252574 πbosomal protein L10a 184

441408 AI733249 Hs 126897 ESTs 184

453994 BE180964 Hs 165590 πbosomal protein S13 184

444518 AH60278 Hs 146884 ESTs 184

402407 predicted exon 18 4

404270 predicted exon 184

409103 AF251237 Hs 112208 XAGE-1 protein 184

415198 AW009480 Hs 943 natural killer cell transcript 4 183

430771 BE387244 Hs 2664 flavin containing monooxygenase 4 183

432636 AA340864 Hs 278562 claudm 7 183

433504 NM 014874 Hs 3363 KIAA0214 gene product 18 3

415606 W70022 gb zd51e10 r1 Soares_fetal_heart_NbHH19W Homo sa 18 3

401401 BE047878 Hs 99093 Homo sapiens chromosome 19, cosmid R28379 18 3

420758 AW297536 Hs 33053 ESTs 18 3

457520 AA553495 Hs 162264 ESTs 18 3

432323 AK001409 Hs 274356 hypothetical protein FU10547 183

404750 predicted exon 18 3

450645 AL117441 Hs 25264 DKFZP434N126 protein 183

445160 AI299144 Hs 150797 ESTs 18 3

418461 BE242781 Hs 288037 Homo sapiens cDNA FU12999 fis, clone NT2RP3000 18 3

401809 predicted exon 183

458121 S42416 Hs 74647 Human T-cell receptor active alpha-chain mRNA from 183

435106 AA100847 Hs 193380 ESTs, Highly similar to AF174600 1 F-box protein Fbx 183

448398 AW444655 Hs 170838 ESTs 183

428145 BE243327 Hs 182626 chromosome 22 open reading frame 5 182

445302 AK001537 Hs 12488 hypothetical protein FLJ10675 18 2

407352 H47860 gb yp76h12 r1 Soares fetal liver spleen 1 NFLS Homo s 18 2

413190 AA151802 Hs 40368 adaptor-related protein complex 1, sigma 2 subunit 182

436371 AI821912 Hs 113912 ESTs 182

400965 predicted exon 18 2

433427 AI816449 Hs 171889 cholinephosphotraπsferase 1 182

427504 AA776743 Hs 191589 ESTs 182

426759 AI590401 Hs 21213 ESTs 182

423792 AW135866 Hs 245854 ESTs 18 2

406826 AW516005 Hs 84298 CD74 antigen (mvaπaπt polypeptide of major histocom 18 1

406659 AA663985 Hs 277477 major histocompatibility complex, class I, C 181

437453 AI761350 Hs 181391 hypothetical protein DKFZp761G2113 181

409276 AW372097 Hs 278429 hepatocellular carcinoma-associated antigen 59 18 1

449628 AI697676 Hs 197713 ESTs 181

421043 BE379455 Hs 89072 ESTs 181

442344 AI022925 Hs 301212 ESTs 181

448744 AL135424 Hs 9469 phosphoinositol 3-phosphate binding proteιn-1 18 1

416062 AA724811 Hs 74427 p53-ιnduced protein 181

414500 W24087 Hs 76285 DKFZP564B167 protein 181 427272 NM.001096 Hs 174140 ATP citrate lyase 18 1

403964 predicted exon 18 1

433217 AB040914 Hs 278628 KIAA1481 protein 18 1

427902 AI809202 Hs 208343 ESTs, Weakly similarto cerebroside sulfofransferase [H 18 1

449586 AI863918 Hs 195078 ESTs 18 1

430826 U10061 Hs 248019 POU domain, class 4, transcπption factor 3 181

414195 BE263293 gb 601144881F2 NIH.MGC.19 Homo sapiens cDNA 181

416305 AU076628 Hs 79187 coxsackie virus and adenovirus receptor 181

411088 BE247593 Hs 145053 ESTs 181

419407 AW410377 Hs 41502 Homo sapiens cDNA FLJ21276 fis, clone COL01829 181

407938 AA905097 Hs 85050 phospholamban 18 1

449360 AI640623 Hs 252720 ESTs 181

417286 AA122237 Hs 81874 microsomal glutathione S transferase 2 180

405515 predicted exon 180

439319 AW016401 Hs 233476 ESTs 180

419387 BE379356 Hs 90107 cell membrane glycoprotein, 110000M(r) (surface antig 180

414015 AA340987 Hs 75693 prolylcarboxypeptidase (aπgiotensmase C) 180

447778 BE620592 Hs 71190 ESTs 180

435523 T62849 Hs 11090 high affinity immunoglobulin epsilon receptor beta sub 180

429230 AF088991 Hs 198274 NADH dehydrogenase (ubiquinoπe) 1 beta subcomplex 180

457822 AA970001 Hs 150319 ESTs 180

442424 AI342715 Hs 129569 ESTs, Moderately similar to B34087 hypothetical prate 180

418394 AF132818 Hs 84728 Kruppel like factor 5 (intestinal) 180

413477 AI815825 Hs 48756 ESTs, Moderately similar to neuronal STOP protein [M 180

405277 predicted exon 180

450192 AA263143 Hs 24596 RAD51-ιntera5tιng protein 180

442191 W95186 Hs 8136 endothelial PAS domain protein 1 180

429490 AI971131 Hs 293684 ESTs, Weakly similar to alternatively spliced product u 180

406744 AA554082 Hs 279860 hypothetical protein FLJ20030 179

425205 NM 005854 Hs 155106 receptor (calcitonm) activity modifying protein 2 179

414387 AL043148 Hs 186257 ESTs 179

411811 AW864370 gb PM4-SN0016-100500-004-h09 SN0016 Homo sapie 179

433882 U90441 Hs 3622 procollagen proline, 2-oxoglutarate 4-dιoxygenase (pro 179

414333 BE274887 gb 601122959F1 NIH.MGC.20 Homo sapiens cDNA 179

403747 predicted exon 179

435542 AA687376 Hs 269533 ESTs 179

403093 predicted exon 179

412088 AI688496 Hs 108932 ESTs 179

450506 NM.004460 Hs 418 fibroblast activation protein, alpha 179

404763 predicted exon 179

454633 AW811380 gb IL3-ST0143-290999 019 D05 ST0143 Homo sapien 179

440788 AI806594 Hs 128577 ESTs 179

411800 N39342 Hs 5184 TH1 drosophila homolog 179

441361 BE263308 Hs 7797 TERF1 (TRF1) interacting nuclear factor 2 178

422033 AW245805 Hs 110903 daudin 5 (transmembrane protein deleted in velocardiof 178

405333 predicted exon 178

408297 R17710 Hs 113314 ESTs 178

403036 predicted exon 178

417924 AU077231 Hs 82932 cyclin D1 (PRAD1 parathyroid adenomatosis 1) 178

417091 AA193283 Hs 291990 ESTs 178

440789 AB007857 Hs 7416 KIAA0397 gene product 178

438397 AA806478 Hs 123206 ESTs 178

435948 AA702675 Hs 114135 ESTs 178

450273 AW296454 Hs 24743 hypothetical protein FU20171 178

435969 W85773 Hs 191386 ESTs 17 8

427031 AA397601 Hs 125147 ESTs 178

454505 AW801365 gb IL5-UM0067-240300-050 a01 UM0067 Homo sapi 178

403447 predicted exon 178

433297 AV658581 Hs 282633 ESTs 178

443326 BE156494 Hs 188478 ESTs 178

448283 AI340462 Hs 182978 πbosomal protein L12 178

458067 AA393603 Hs 36752 Homo sapiens cDNA FLJ22834 fis, clone KAIA4314 178

452359 BE167229 Hs 28206 Homo sapiens clone 24659 mRNA sequence 178

434098 AA625499 gb af69g08 r1 Soares.NhHMPu.S1 Homo sapiens cDN 178

450911 AA011586 Hs 272097 ESTs 177

410342 R31350 Hs 743 Fc fragment of IgE, high affinity I, receptor for, gamma 177

407082 Z47055 gb Human partial cDNA sequence, farnesyl pyrophosph 177

415271 X94232 Hs 78335 microtubule associated protein, RP/EB family, member 177

417413 AA197072 Hs 86092 Human DNA sequence from clone RP11-243J16 on chr 177

408937 AA210734 Hs 291386 ESTs 177

433459 AA593498 gb nn27b05 s1 NCI CGAP Gas1 Homo sapiens cDNA 177

459536 AI254723 Hs 145496 ESTs 177

428500 AI815395 Hs 184641 delta-6 fatty acid desaturase 177

433463 R41963 Hs 4197 ESTs 177

406537 predicted exon 177

410003 AA079487 gb zm97f08 s1 Stratagene colon HT29 (937221) Homo 177

440857 AA907808 Hs 135556 ESTs 177

451072 AA013451 Hs 117929 ESTs 177

418693 AI750878 Hs 87409 thrombospondin 1 177

443624 BE616129 Hs 9651 related RAS viral (r-ras) oncogene homolog 176

422626 AA344932 Hs 118786 metallolhionein 2A 176

410756 AB037820 Hs 66159 KIAA1399 protein 176

436621 AI266254 Hs 132929 ESTs 176

453317 NM 002277 Hs 41696 keratin, hair, acιdιc,1 176 456828 AF156889 Hs.148427 UM homeobox protein 3 17.6

421486 AW408800 Hs.104859 hypothetical protein DKFZp762E1312 17.6

428834 AW899713 Hs.10338 ^• ESTs 17.6

451419 R36309 Hs.174369 EST 17.6

448413 AI745379 Hs.4291 ESTs 17.6

424323 AA338791 Hs.146763 nascent-polypeptide-associated complex alpha polypept 17.6

423943 AF163570 Hs.135756 polymerase (DNA-directed) kappa 17.6

439423 BE536678 Hs.147099 ESTs 17.6

434025 AF114264 Hs.216381 Homo sapiens clone HH409 unknown mRNA 17.6

408246 N55669 Hs.43946 L13 protein 17.6

441579 AW468847 Hs.127194 ESTs 17.5

420867 NM.014183 Hs. 00002 HSPC162 protein 17.5

453680 AL079647 Hs.14485 ESTs 17.5

400202 predicted exon 17.5

410768 AF038185 Hs.66187 Homo sapiens clone 23700 mRNA sequence 17.5

409932 AI376750 Hs.57600 adaptor-related protein complex 1, sigma 1 subunit 17.5

425563 AF084199 Hs.299837 ESTs 17.5

440475 AI807671 Hs.128343 ESTs 17.5

452767 AW014195 Hs.61472 ESTs, Weakly similar to unknown [S.cerevisiae] 17.5

410570 AI133096 Hs.64593 ATP synthase, H+ transporting, mitochondrial F1F0, su 17.4

419600 AA448958 Hs.91481 NEU1 protein 17.4

419588 AI347205 Hs.91375 Human clone 23614 mRNA sequence 17.4

428975 NM 004672 Hs.194694 mitogen-activated protein kinase kinase kinase 6 17.4

448928 AI350260 Hs.5384 Homo sapiens cDNA FLJ11743 fis, clone HEMBA100 17.4

403924 predicted exon 17.4

419889 AA251600 gb:zs10d12.rfNCI_CGAP_GCB1 Homo sapiens cDNA 17.4

405023 AW408800 Hs.104859 hypothetical protein DKFZp762E1312 17.4

426065 N32049 gb:yw96g08.s1 Soares_pIacenta_8to9weeks_2NbHP8to 17.4

453199 AI336266 Hs.301854 Homo sapiens PRO0412 mRNA, complete eds 17.4

455132 AW857955 gb:PMO-CT0325-151299-002-A12 CT0325 Homo sapi 17.4

442932 AA457211 Hs.8858 bromodomaiπ adjacent to zinc finger domain, 1 A 17.4

432065 AA401039 Hs.2903 protein phosphatase 4 (formerly X), catalytic subunit 17.3

444652 BE513613 Hs.11538 actin related protein 2/3 complex, subunit 1 A (41 kD) 17.3

417935 R53697 Hs.170044 ESTs 17.3

430050 AA430993 Hs.227913 API5-like 1 17.3

446272 BE268912 Hs.14601 hematopoietic cell-specific Lyn substrate 1 17.3

425996 W67330 Hs.81256 S100 calcium-binding protein A4 (calcium protein, calv 17.3

416964 D87467 Hs.80620 guanine nucleotide exchange factor for Rap1 ; M-Ras-re 17.3

437418 AI478954 Hs.59459 ESTs 17.3

447255 AI884908 Hs.158607 ESTs 17.3

402203 predicted exon 17.3

417611 AW993983 gb:RC1-BN0035-130400-013-a04 BN0035 Homo sapie 17.3

426560 AA381661 Hs.119878 ESTs 17.3

446163 AA026880 Hs.25252 Homo sapiens cDNA FLJ13603 fis, clone PLACE1010 17.3

445017 AI205493 Hs.176860 ESTs 17.3

438658 AI222068 Hs.123571 ESTs 17.3

442238 AW135374 Hs.270949 ESTs 17.3

443195 BE148235 Hs.193063 Homo sapiens cDNA FLJ14201 fis, clone NT2RP3002 17.3

442609 AL020996 Hs.8518 seleπoproteiπ N 17.2

416591 AA091976 Hs.79387 proteasome (prosome, macropain) 26S subunit, ATPase 17.2

403674 predicted exon 17.2

430514 AA318501 Hs.241587 megakaryocyte-enhanced gene transcript 1 protein 17.2

411696 AW857404 gb:CM3-CT0313-291199-046-c11 CT0313 Homo sapie 17.2

434560 R13052 Hs.3964 Homo sapiens clone 24877 mRNA sequence 17.2

422627 BE336857 Hs.118787 transforming growth factor, beta-induced, 68kD 17.2

414364 D38521 Hs.75935 KIAA0077 protein 17.2

409119 AA531133 Hs.4253 G protein-coupled receptor 44 17.2

425640 U34051 Hs.299204 ESTs, Highly similar to CD5S.HUMAN CYCLIN-DE 17.2

436044 BE247571 Hs.15627 Nit protein 2 17.2

401657 predicted exon 17.2

449763 A1822112 Hs.118241 ESTs 17.2

409601 AF237621 Hs.80828 keratin 1 (epidermolytic hyperkeratosis) 17.2

449636 AI656608 Hs.281328 ESTs 17.2

444958 AW292643 Hs.167047 ESTs 17.2

429978 AA249027 Hs.241507 ribosomal protein S6 17.2

453043 AW136440 Hs.224277 ESTs 17.2

458640 AI284935 gb:qk55g09.x1 NCI_CGAP_Co8 Homo sapiens cDNA 17.1

456329 T41418 gb:ph1h3_19/1TV Outward Alu-primed hπcDNA librar 17.1

414839 X63692 Hs.77462 DNA (cytosine-5-)-methyltransferase 1 17.1

403662 predicted exon 17.1

411651 AW855392 gb:CM3-CT0275-191099-024-e12 CT0275 Homo sapie 17.1

404097 predicted exon 17.1

447252 R90916 gb:yn01e10.r1 Soares adult brain N2b4HB55Y Homo s 17.1

430024 AI808780 Hs.227730 integrin, alpha 6 17.1

412828 AL133396 Hs.74621 prion protein (p27-30) (Creufzfeld-Jakob disease, Gerst 17.1

444558 AW181975 Hs.165892 ESTs 17.1

420869 X58964 Hs.123638 regulatory factor X, 1 (influences HLA class II expressi 17.1

448812 H30775 Hs.22140 BM88 antigen 17.0

431777 AA570296 Hs.105470 found in inflammatory zone 1 17.0

422007 AI739435 Hs.39168 ESTs 17.0

403051 predicted exon 17.0

402427 predicted exon 17.0

417408 F17211 Hs.86092 .Human DNA sequence from clone RP11-243J16 on chr 17.0

450598 AF151076 Hs.25199 hypothetical protein 17.0 421121 AA459028 Hs 86228 TRIAD3 protein 170

458488 AL040565 Hs 209544 ESTs 170

417158 AW965223 Hs 110062 ESTs, Weakly similarto ACR3.HUMAN 30 KD ADIP 170

439318 AW837046 Hs 6527 G protein-coupled receptor 56 170

428758 AA433988 Hs 98502 Homo sapiens cDNA FLJ14303 fis, clone PLACE2000 170

447572 AI631546 Hs 159732 ESTs 170

434434 AA633516 Hs 157201 ESTs 170

409994 D86864 Hs 57735 acetyl LDL receptor; SREC 170

408927 AW295650 Hs 255453 ESTs 170

439093 AA534163 Hs 5476 seπne protease inhibitor, Kazal type, 5 170

454466 AA984138 Hs 279895 Homo sapiens mRNA for KIAA1578 protein, partial cd 170

426996 AW968934 Hs 173108 Homo sapiens cDNA FU21897 fis, clone HEP03447, 17 0

436659 AI217900 Hs 144464 ESTs 170

422731 AL138411 gb DKFZp434A1229_r1 434 (synonym htes3) Homo s 170

429294 AA095971 Hs 198793 KIAA0750 gene product 170

432847 BE266941 Hs 279554 proteasome (prosome, macropain) 26S subunit, non AT 169

416977 AW130242 Hs 293476 ESTs 169

406827 AA971409 Hs 84298 CD74 antigen (mvaπant polypeptide of major histocom 169

453758 U83527 gb HSU83527 Human fetal brain (M Lovett) Homo sap 169

431314 AI732204 Hs 105423 ESTs 169

423185 BE299590 Hs 125078 ornithine decarboxylase aπtizyme 1 169

435086 AW975243 Hs 122596 ESTs 169

447383 N24231 gb yx22a11 r1 Soares melanocyte 2NbHM Homo sapie 169

456251 R13326 Hs 21303 ESTs 169

456327 H68741 Hs 38774 ESTs 169

450594 N31036 gb yx51g04 rϊ'Soares melanocyte 2NbHM Homo sapie 169

428177 AA423967 Hs 178113 ESTs, Moderately similar to kinesm like protein 9 [M m 169

453250 AI346520 Hs 121619 chromosome 11 open reading frame 15 169

418294 AF061739 Hs 83954 protein associated with PRK1 169

446546 BE167687 Hs 156628 ESTs 169

421100 AW351839 Hs 124660 Homo sapiens cDNA FLJ21763 fis, clone COLF6967 169

455993 BE179085 gb RC0-HT0613-140300-021-d06 HT0613 Homo sapie 169

459375 BE251770 gb 601112470F1 NIH MGC.16 Homo sapiens cDNA 16 9

454803 AW860148 gb RC0 CT0379-290100 032-b10 CT0379 Homo sapie 16 9

445474 AI240014 Hs 259558 ESTs 169

443198 AI039813 gb ox49d06 x1 Soares total fetus Nb2HF8 9w Homo 169

441557 AW452647 Hs 270482 ESTs 169

420206 M91463 Hs 95958 solute camerfamily 2 (facilitated glucose transporter), 169

442202 BE272862 Hs 106534 Homo sapiens cDNA FLJ22625 fis, clone HSI06009 169

416913 AW934714 gb RC1-DT0001-031299 011-a11 DT0001 Homo sapie 169

419355 AA428520 Hs 90061 progesterone binding protein 169

452975 M85521 Hs 69469 dendπtic cell protein 169

432525 AI796096 Hs 109414 ESTs 168

453718 AL119317 Hs 120360 phospholφase A2, group VI (cytosolic, calcium mdepe 168

437270 R18087 Hs 11282 ESTs, Weakly similar to cleft lip and palate transmemb 168

408007 AW135965 Hs 246783 ESTs 16 8

450954 AI904740 Hs 25691 receptor (calcitonin) activity modifying protein 3 168

402958 predicted exon 168

445656 W22050 Hs 21299 ESTs, Weakly similar to AF151840 1 CGI-82 protein [H 168

410684 AA088500 Hs 170298 ESTs 168

437669 A1358105 Hs 123164 ESTs, Weakly similar to match to ESTs AA667999 [H 168

447869 AW139113 Hs 164307 ESTs 168

458025 AI275406 gb ql63c10 x1 Soares_NhHMPu_S1 Homo sapiens cDN 168

445614 AV660763 Hs 110675 apolipopratein C-IV 168

454610 AW810224 gb MR4-ST0125-021199 017-e07 ST0125 Homo sapie 168

449303 AK001495 Hs 23467 hypothetical protein FU10633 168

422105 AI929700 Hs 111680 endosulfine alpha 168

444788 AI871122 Hs 202821 ESTs 168

414057 AI815559 Hs 75730 signal recognition particle receptor ('docking protein') 168

408822 AW500715 Hs 57079 Homo sapiens cDNA FU 13267 fis, clone OVARC1000 168

433379 AA586368 Hs 190232 ESTs 168

441552 AA937975 gb oc08e12 s1 NCI.CGAP.GCB1 Homo sapiens cDN 168

403582 predicted exon 168

433871 W02410 Hs 205555 ESTs 168

439509 AF086332 Hs 58314 ESTs 168

431639 AK000680 Hs 266175 phosphoprotein associated with GEMs 168

430129 BE301708 Hs 233955 hypothetical protein FU20401 168

401465 predicted exon 168

448913 AA194422 Hs 22564 myosin VI 168

410261 AF145713 Hs 61490 schwannomin interacting protein 1 168

421199 BE244219 Hs 102497 paxilliπ 167

450489 A1697990 Hs 224375 ESTs 167

410186 AW602528 gb RC5-BT0562-260100-011-A02 BT0562 Homo sapi 167

447224 BE617125 gb 601441664F1 NIH.MGC.65 Homo sapiens cDNA 167

403010 predicted exon 167

404881 predicted exon 167

445572 AI243445 Hs 189654 ESTs 167

419440 AB020689 Hs 90419 KIAA0882 protein 167

443406 AI056238 Hs 143316 ESTs 167

457901 AW207023 Hs 250497 ESTs, Highly similar to dJ745C221 [H sapiens] 167

448364 T08958 Hs 16561 HSPC141 protein 166

407239 AA076350 Hs 67846 leukocyte immuπoglobulin-like receptor, subfamily B ( 166

401847 predicted exon 166

429523 AK000788 Hs 205280 Homo sapiens cDNA FU20781 fis, clone COL04235 166 432845 AI989751 Hs 150378 ESTs 166

400246 predicted exon 166

404971 predicted exon 166

422954 AW998605 Hs 32399 ESTs, Weakly similar to Similar to Ena-VASP like prat 166

415042 NM 006759 Hs 77837 UDP-glucose pyraphosphorylase 2 166

432201 AI538613 Hs 135657 ESTs 166

456993 AL134577 Hs 200302 ESTs 16 6

456525 AW468397 Hs 100000 S100 calcium binding protein A8 (calgranulm A) 166

444060 AA340277 Hs 10248 Homo sapiens cDNA FU20167 fis, clone COL09512 166

428928 BE409838 Hs 194657 cadheπn 1, type 1, E-cadheπn (epithelial) 166

448199 AI953278 Hs 170557 ESTs 166

443422 R10288 Hs 301529 ESTs 166

401117 predicted exon 16 6

400613 predicted exon 16 6

431214 AA294921 Hs 250811 v-ral simian leukemia viral oncogene homolog B (ras re 166

431649 AL133077 Hs 266746 Homo sapiens cDNA FU22615 fis, clone HSI05118 165

421335 X99977 Hs 103505 ARS component B 165

427154 AL137262 Hs 288991 Homo sapiens cDNA FU22523 fis, clone HRC12507 165

401010 predicted exon 16 5

436678 BE512828 Hs 5273 NADH dehydrogenase (ubiqumone) Fe-S protein 3 (30k 16 5

401589 predicted exon 165

402538 predicted exon 165

430478 NM 014349 Hs 241535 TNF-mducible protein CG12-1 165

437623 D63880 Hs 5719 chromosome condensation-related SMC-associated pro 165

401244 predicted exon 16 5

415167 AA160784 Hs 26410 ESTs 165

438291 BE514605 Hs 289092 Homo sapiens cDNA FU22380 fis, clone HRC07453, 16 5

405183 predicted exon 16 5

436480 AJ271643 Hs 87469 putative acid-sensing ion channel 165

456691 AI023428 Hs 205696 ESTs 16 5

418332 R34976 Hs 78293 ESTs 16 5

446052 AA358760 gb EST67699 Fetal lung II Homo sapiens cDNA 5' end 165

444859 AW449137 Hs 157487 ESTs 16 5

437192 AW975786 Hs 75355 ubiquitin-conjugatmg enzyme E2N (homologous to yea 165

400891 predicted exon 165

448372 AW445166 Hs 170802 ESTs 165

425798 AA364002 gb EST74529 Pineal gland II Homo sapiens cDNA 5' en 165

459253 AL157476 Hs 32913 Homo sapiens mRNA, cDNA DKFZp761 C082 (from c 165

420746 AW195932 Hs 197488 ESTs 164

414717 BE271039 Hs 77060 proteasome (prosome, macropain) subunit, beta type, 6 164

400727 predicted exon 164

422691 NM.003365 Hs 119251 ubiquinol-cytochrame c reductase core protein I 164

405639 predicted exon 164

414444 BE298594 gb 601119754F1 NIH.MGC.17 Homo sapiens cDNA 164

456146 AL034349 Hs 79005 protein tyrosine phosphatase, receptor type, K 164

414610 BE388044 gb 601283747F1 NIH_MGC_44 Homo sapiens cDNA 164

414267 AL078459 Hs 289109 dimethylarginme dimethylaminohydrolase 1 164

401268 predicted exon 164

403613 predicted exon 164

414203 BE262170 gb 601150419F1 NIH.MGC.19 Homo sapiens cDNA 164

454315 AW373564 Hs 251928 nuclear pore complex interacting protein 164

452114 N22687 Hs 8236 ESTs 164

404638 predicted exon 164

404600 predicted exon 163

448855 AF070574 Hs 22316 Homo sapiens clone 24819 mRNA sequence 163

406629 AW277078 Hs 181165 eukaryotic translation elongation fxtor 1 alpha 1 163

450957 BE515202 Hs 21497 Homo sapiens mRNA for FLJ00042 protein, partial eds 163

449966 H60542 Hs 37848 ESTs 163

402585 predicted exon 163

436008 AI078428 Hs 58785 ESTs 163

401492 predicted exon 163

412288 NM.003005 Hs 73800 selectm P (granule membrane protein 140kD, antigen C 163

405088 predicted exon 163

437345 BE259522 Hs 5556 NADH dehydrogenase (ubiqumone) 1, alpha/beta subco 163

432280 BE440142 Hs 2943 signal recognition particle 19kD 163

419596 BE379320 Hs 91448 MKP-1 like protein tyrosine phosphatase 163

428801 AW277121 Hs 254881 ESTs 16 3

431394 AK000692 Hs 252351 HERV-H LTR-associating 2 163

452998 BE019681 Hs 6019 Homo sapiens cDNA FU21288 fis, clone COL01927 16 3

439938 AI147392 Hs 124607 ESTs 163

418844 M62982 Hs 1200 arachidonate 12-lιpoxygenase 163

.446081 AA972412 Hs 13755 f-box and WD-40 domain protein 2 163

443534 AI076123 gb oy92e04 x1 Soares_fetal_lιver_spleen_1NFLS_S1 H 163

459510 AA076706 gb 7B01B02 Chromosome 7 Fetal Brain cDNA Library 163

450517 AI523755 Hs 59236 ESTs, Weakly similar to B35049 ankyπn 1, erythrocyte 163

451938 AI354355 Hs 16697 down-regulator of transcπption 1, TBP-bindmg (negativ 163

454478 AW805749 gb QV1-UM0105-180400-162-f10 UM0105 Homo sap 162

407214 AA412048 Hs 279574 CGI-39 protein, cell death-regulatory protein GRIM19 162

406580 predicted exon 162

409452 BE336714 Hs 289271 cytochrome c-1 162

416841 N33878 Hs 249495 heterogeneous nuclear πbonucleoprotein A1 162

458710 AV660856 gb AV660856 GLC Homo sapiens cDNA clone GLCG 162

450657 AK001579 Hs 25277 hypothetical protein FU21065 162

404230 predicted exon 16 2 439471 W69839 Hs.58033 ESTs 16.2

400848 predicted exon 16.2

428797 AA496205 Hs.193700 Homo sapiens mRNA; cDNA DKFZp586l0324 (from c 16.2

416272 AA178882 gb:zp38b09.r1 Stratagene muscle 937209 Homo sapiens 16.2

444465 AI206592 Hs.143843 ESTs 16.2

431257 AF039597 gb:Homo sapiens Ku86 autoanligen related protein 1 (K 16.2

447775 BE179318 gb:RC1-HT0615-290300-021-g05 HT0615 Homo sapie 16.2

403833 predicted exon 16.2

444140 AV648089 Hs.282383 ESTs 16.2

446102 AW168067 Hs.252956 ESTs 16.2

416475 T70298 gb:yd26g02.s1 Soares fetal liver spleen 1NFLS Homos 16.2

430783 AW971248 Hs.291289 ESTs, Weakly similar to ALU1.HUMAN ALU SUBFA 16.2

414070 AW963783 gb:EST375856 MAGE resequences, MAGH Homo sap 16.2

444283 AI138971 Hs.154636 ESTs 16.2

405599 X92715 Hs.3057 zinc finger protein 74 (Cos52) 16.2

409427 AW389668 gb:RC2-ST0168-071299-013-f06 ST0168 Homo sapien 16.2

409417 AA156247 Hs.295908 ESTs, Weakly similar to ALU7 HUMAN ALU SUBFA 16.2

435380 AA679001 Hs.192221 ESTs 16.2

406752 AI285598 Hs.217493 anπexin A2 16.2

406096 F12200 Hs.5811 chromosome 21 open reading frame 59 16.2

417551 AI816291 Hs.82273 hypothetical protein 16.2

441252 AW360801 Hs.183047 ESTs, Weakly similar to unnamed protein product [H.s 16.2

419608 AL037237 Hs.91586 transmembrane 9 superfamily member 1 16.1

438894 AI630819 Hs.300431 ESTs 16.1

451287 AK002158 Hs.26194 hypothetical protein FU11296 16.1

412499 AW956916 Hs.11238 KIAA0622 protein; Drosophila "multiple asters" (Mast 16.1

433355 AI808235 gb:wf44e01.x1 Soares_NFL_T_GBC_S1 Homo sapien 16.1

416818 AI986408 Hs.204766 ESTs, Weakly similar to B48013 proline-rich proteogly 16.1

438765 AI031888 Hs.132594 ESTs 16.1

424470 BE244261 Hs.5615 nuclear RNA export factor 1 16.1

416194 H27114 Hs.301212 ESTs 16.1

446702 R44518 Hs.143496 ESTs 16.1

414222 AL135173 Hs.878 sorbitol dehydrogenase 16.1

443122 AI806656 Hs.209022 ESTs, Weakly similarto Pro-Pol-dUTPase polyprotein 16.1

448648 BE614345 Hs.159089 ESTs 16.1

456394 W28506 gb:48f1 Human retina cDNA randomly primed sublibra 16.1

445887 AI263105 Hs.145597 ESTs 16.1

412332 AW937661 Hs.288324 Homo sapiens cDNA FU13283 fis, clone OVARC1001 16.1

403912 predicted exon 16.1

441446 R66269 Hs.28714 ESTs 16.1

403153 predicted exon 16.0

444907 AW772596 Hs.148586 ESTs 16.0

421946 R99629 Hs.109773 hypothetical protein FLJ20625 16.0

437513 AW410681 Hs.5648 proteasome (prosome, mxropain) 26S subunit, non-AT 16.0

407752 AA573581 Hs.13328 ESTs 16.0

447953 AI804218 Hs.209614 Homo sapiens cDNA: FU22343 fis, clone HRC06043 16.0

425708 AK001342 Hs.14570 Homo sapiens cDNA: FLJ22530 fis, clone HRC12866 16.0

421449 AA713491 Hs.291501 ESTs 16.0

418323 NM 002118 Hs.1162 major histocompatibility complex, class II, DM beta 16.0

447787 BE620108 gb:601483015F1 NIH MGC 69 Homo sapiens cDNA 16.0

422716 AI702835 Hs.124475 ESTs 16.0

443958 BE241880 Hs.10029 cathepsin C 16.0

417908 AA207221 gb:zq55h04.s1 Stratagene neuroepithelium (937231) Ho 16.0

438542 AA810131 Hs.123317 ESTs 16.0

400288 X06256 Hs.149609 integrin, alpha 5 (fibronectin receptor, alpha polypeptid 16.0

456825 H67220 Hs.146406 nitrilase 1 16.0

431360 NM 000427 Hs.251680 loricriπ 16.0

414266 BE267834 gb:601124428F1 NIH MGC 8 Homo sapiens cDNAc 16.0

440571 AA904461 Hs.130798 ESTs 16.0

426075 AW513691 Hs.270149 ESTs 16.0

413488 BE144017 Hs.184693 transcription elongation factor B (Sill), polypeptide 1 (1 16.0

446767 AI380107 Hs.158954 ESTs 16.0

418008 W56044 Hs.211556 Homo sapiens cDNA: FLJ23378 fis, clone HEP16248 16.0

404239 predicted exon 16.0

458401 AW236939 Hs.172154 ESTs 16.0

412955 BE241849 Hs.75082 ras homolog gene family, member G (rho G) 15.9

423072 AI792946 Hs.123116 solute carrier family 12 (sodium potassium/chloride tran 15.9

444954 AW247076 Hs.12163 eukaryotic translation initiation factor 2, subunit 2 (beta 15.9

449023 AI623261 Hs.248875 ESTs 15.9

435729 BE048886 Hs.275017 EST 15.9

438575 BE304709 Hs.146550 myosin, heavy polypeptide 9, non-muscle 15.9

413047 H02209 gb:yj38c09.r1 Soares placenta Nb2HP Homo sapiens cD 15.9

425997 AK000086 Hs.165948 hypothetical protein FLJ20079 15.9

446863 AW614370 Hs.254620 ESTs 15.9

448564 AL044962 Hs.21453 Homo sapiens mRNA for iπositol 1 ,4,5-trisphosphate 3 15.9

455640 BE064059 gb:QV3-BT0296-010300-111-e04 BT0296 Homo sapie 15.9

404345 AA730407 Hs.159156 protocadherin 11 15.9

418512 AW498974 Hs.89981 diacylglycerot kinase, zeta (104kD) 15.9

411551 AW851309 gb:IL3-CT0220-170200-067-C11 CT0220 Homo sapien 15.9

446726 AW300144 Hs.209209 Homo sapiens cDNA FU11629 fis, clone HEMBA100 15.9

410748 BE383816 Hs.136005 ESTs, Highly similar to bG115G20.2 [H.sapiens] 15.9

449618 AI076459 Hs.14366 Homo sapiens cDNA FLJ12819 fis, clone NT2RP2002 15.9

429697 AW296451 Hs.24605 ESTs 15.9

424012 AW368377 Hs.137569 tumor protein 63 kDa with strong homology to p53 15.9 403151 predicted exon 158

452363 AI582743 Hs 94953 ESTs, Highly similar to C1QC.HUMAN COMPLEME 158

425971 AF135024 Hs 165296 kallikrein 13 158

432826 X75363 Hs 250770 kallikrem 15 158

431972 AI805145 Hs 191711 ESTs 158

400269 predicted exon 158

404703 AI904493 Hs 99890 polymerase (DNA directed), delta 1 , catalytic subunit (1 158

449335 AW150717 Hs 296176 STAT induced STAT inhibitor 3 158

418443 NM 005239 Hs 85146 v-ets avian erythroblastosis virus E26 oncogene homolo 158

445773 H73456 Hs 13299 Homo sapiens mRNA, cDNA DKFZp761 M0111 (from 158

433782 AF090945 gb Homo sapiens clone HQ0670 158

406473 predicted exon 158

420831 AA280824 Hs 190035 ESTs 158

402939 predicted exon 158

405196 predicted exon 158

452947 AW130413 gb xf50f04 x1 NCI_CGAP_Gas4 Homo sapiens cDNA 158

414170 AA335996 Hs 3743 matπx metalloprotemase 24 (membrane-inserted) 158

437133 AB018319 Hs 5460 KIAA0776 protein 158

458356 AI024855 Hs 131575 ESTs 158

407857 AI928445 Hs 92254 hypothetical protein FLJ20163 158

405687 predicted exon 158

415189 L34657 Hs 78146 platelet/endothelial cell adhesion molecule (CD31 antig 158

408662 AW247699 Hs 105897 ESTs 157

448338 AI492857 gb th72h08 x1 Soares.NhHMPu.S1 Homo sapiens cDN 157

402694 predicted exon 157

430224 AW675175 Hs 235975 hypothetical protein DKFZp434D0412 157

458792 N56666 gb yw75e02 r1 Soares_placeπta_8to9weeks_2NbHP8to 157

402944 predicted exon 157

422675 BE018517 Hs 119140 eukaryotic translation initiation factor 5A 157

408661 AW247625 gb 28200945pπme NIH MGC 7 Homo sapiens cDNA 157

423238 AA323569 Hs 280482 ESTs 157

421517 AB018352 Hs 105399 KIAAO809 protein 157

429865 AB023217 Hs 225968 KIAA1000 protein 157

440815 AW071945 Hs 7436 putative acyltransferase 157

400634 predicted exon 157

451034 AL050341 Hs 25846 zinc metalloprotemase, STE24 (yeast, homolog) 157

457571 AI375726 Hs 279918 hypothetical protein 157

450105 BE281124 Hs 288013 similar to yeast BET3 (S cerevisiae) 157

407464 AJ276396 gb Homo sapiens mRNA for matπx extracellular phosp 157

439465 AF086285 gb Homo sapiens full length insert cDNA clone ZD47B 157

451837 T92157 Hs 16970 ESTs 157

435313 AI769400 Hs 189729 ESTs 157

402738 predicted exon 157

432966 AA650114 gb ns92h09 s1 NCI CGAP Pr3 Homo sapiens cDNA c 157

457666 AW470302 Hs 129663 ESTs 157

401269 predicted exon 157

427509 M62505 Hs 2161 complement component 5 receptor 1 (C5a ligand) 157

418846 AI821602 Hs 115127 ESTs 156

448891 AI587332 Hs 209115 ESTs 156

445930 AF055009 Hs 13456 Homo sapiens clone 24747 mRNA sequence 156

421254 AK001724 Hs 102950 coat protein gamma-cop 156

447073 AW204821 Hs 157726 ESTs 156

445438 AB014578 Hs 12707 KIAA0678 protein 156

432126 AA865239 Hs 55144 ESTs 156

424091 AF235097 Hs 139263 calcium channel, voltage-dependent, alpha 1F subunit 156

440832 AI057548 Hs 128224 ESTs 156

449228 AJ403107 Hs 148590 ESTs, Weakly similar to AF208846 1 BM-004 [H sapie 156

434253 AI393345 Hs 116215 ESTs 15 6

459270 AL039604 gb DKFZp434E2211_r1 434 (synonym htes3) Homo s 156

454425 AW300927 Hs 27192 hypothetical protein dJ1057B202 15 6

412055 AA099907 Hs 271806 ESTs 156

400837 predicted exon 156

458866 BE616694 Hs 288042 Homo sapiens cDNA FU14299 fis, clone PLACE1010 156

417124 BE122762 Hs 25338 ESTs 156

414376 BE393856 Hs 66915 ESTs, Weakly similarto 167Kd protein [H sapiens] 156

418636 AW749855 gb QV4-BT0534-281299-053-c05 BT0534 Homo sapie 156

454128 AL031259 Hs 41639 programmed cell death 2 156

441074 AW500001 Hs 4783 Homo sapiens cDNA FU22035 fis, clone HEP08838 156

451742 T77609 Hs 117970 ankyππ 2, neuronal 156

403687 predicted exon 156

431838 AI097229 Hs 217484 ESTs 156

402855 predicted exon 156

449635 AI989942 Hs 232150 ESTs 156

434392 AW983709 Hs 268051 ESTs 156

444301 AK000136 Hs 10760 hypothetical protein FLJ20129 156

414973 C19089 gb C19089 Human placenta cDNA (TFujiwara) Homo 155

428374 AW405156 Hs 183994 protein phosphatase 1, catalytic subunit, alpha isoform 155

415745 AI301107 Hs 150790 ESTs 155

432532 AW058459 Hs 162246 ESTs 155

417112 AA193439 gb zr41b09 s1 Soares.NhHMPu.S1 Homo sapiens cDN 155

418101 AL047476 Hs 98485 gap junction protein, beta 4 (connexin 303) 155

453110 AW384928 Hs 225160 Homo sapiens cDNA FU13102 fis, clone NT2RP3002 155

458606 AJ239397 gb AJ239397 Uni-ZAP XR retinal pigment epithelium H 155

436989 AA741028 Hs 256155 ESTs 155 407386 AF011757 gb Homo sapiens RAGE binding protein (P12) mRNA, 155

443684 AI659166 Hs 207144 ESTs 155

454666 AW812994 gb RC3-ST0186-230300-019-g02 ST0186 Homo sapien 155

430492 U15197 Hs 300803 Human histo-blood group ABO protein mRNA, partial 155

439460 AA836220 Hs 13774 ESTs 155

449231 BE410360 gb 601302340F1 NIH MGC 21 Homo sapiens cDNA 155

453060 AW294092 Hs 21594 ESTs 155

416961 BE391476 Hs 80617 πbosomal protein S16 155

439988 AA860119 Hs 255976 ESTs 155

400917 predicted exon 155

424585 AA464840 gb zx43h11 r1 Soares_total_fetus_Nb2HF8_9w Homo 155

431029 BE392725 Hs 248571 Homo sapiens PAC clone RP5-1163J12 from 7q21 2-q3 155

441680 AW444598 Hs 7940 RAP1, GTP-GDP dissociation stimulator 1 155

437830 AB020658 Hs 5867 KIAA0851 protein 155

409479 BE163800 Hs 136912 ESTs 155

409885 AW503068 gb UI-HF-BPOp aje-g-10-O-UI r1 NIH.MGC.51 Homo 154

459090 AA443323 Hs 107812 ESTs, Weakly similar to SPOP [H sapiens] 154

429324 AA488101 Hs 199245 inactivation escape 1 154

403766 predicted exon 154

413970 U59309 Hs 75653 fumarate hydratase 154

456674 BE266120 Hs 269358 ESTs 154

417931 W95642 Hs 82961 trefoil factor 3 (intestinal) 154

430125 U46418 Hs 233950 serine protease inhibitor, Kuπitz type 1 154

452154 AW953265 Hs 271277 hypothetical protein from EUROIMAGE 363668 154

422984 W28614 Hs 75984 choπonic somatomammotropm hormone 2 154

408649 BE242232 Hs 26045 protein tyrosine phosphatase, receptor type A 154

417497 AW402482 Hs 82212 CD53 antigen 154

404666 predicted exon 154

456847 AI360456 Hs 37776 ESTs 154

426995 AA400646 Hs 221988 ESTs 154

445350 AF052112 Hs 12540 lysophospholipase I 154

450214 BE439763 Hs 227571 regulator of G protein signalling 4 154

449733 R74546 Hs 29438 Homo sapiens CDNA FLJ12094 fis clone HEMBB100 154

411660 AW855718 gb RC1-CT0279-070100 021-a06 CT0279 Homo sapie 154

442653 BE269247 Hs 170226 Homo sapiens clone 23579 mRNA sequence 154

447552 AI394125 Hs 160413 ESTs 154

448712 W01046 Hs 181634 Homo sapiens cDNA FLJ23602 fis, clone LNG15735 154

420180 AI004035 Hs 25191 ESTs 154

440099 AL080058 Hs 6909 DKFZP564G202 protein 154

427550 BE242818 Hs 179606 nuclear RNA helicase, DECD vaπant of DEAD box fam 154

432894 AW167668 Hs 279772 brain specific protein 153

412113 AW161274 Hs 74427 p53-ιπduced protein 153

431614 AI189827 gb qd19d07 x1 Soares_placenta_8to9weeks_2NbHP8to 153

445870 AW410053 Hs 13406 syntaxin 18 153

424347 AA723883 Hs 145513 Homo sapiens mRNA, cDNA DKFZp434L0435 (from 153

425132 AW250114 gb 28211345pπme NIH.MGC.7 Homo sapiens cDNA 153

439756 AL359651 Hs 283852 Homo sapiens mRNA full length insert cDNA clone EU 153

432946 U60899 Hs 279854 mannosidase, alpha, class 2B, member 1 153

406130 predicted exon 153

453359 AA448787 Hs 24872 ESTs, Weakly similar to aortic carboxypeptidase like p 153

405491 predicted exon 153

436481 AA379597 Hs 5199 HSPC150 protein similarto ubiquitin-conjugating enzy 153

446826 AK000626 Hs 16230 hypothetical protein FLJ20619 153

441211 AW946155 Hs 7750 hypothetical protein AL133206 153

418711 AW247977 Hs 87595 franslocase of inner mitochondπal membrane 22 (yeast) 153

457301 AA469146 gb πc67e03 s1 NCI CGAP Pr1 Homo sapiens cDNA c 153

449999 AI679421 Hs 231098 ESTs, Highly similar to ALU4 HUMAN ALU SUBFA 153

439090 H65724 Hs 271663 ESTs 153

416586 D44643 Hs 14144 secreted modular calcium binding protein 1 153

411940 AW876686 gb CM4-PT0031-180200-507-e05 PT0031 Homo sapie 153

407639 AW205369 Hs 252936 ESTs 153

458012 AI424899 Hs 188211 ESTs 153

426490 NM.001621 Hs 170087 aryl hydrocarbon receptor 153

408741 M73720 Hs 646 carboxypeptidase A3 (mast cell) 153

437371 AK000868 Hs 5570 hypothetical protein FLJ10006 153

437134 AA349944 Hs 42915 ARP2 (actin related protein 2, yeast) homolog 153

441890 AI809547 Hs 128075 ESTs 153

409442 AA310162 Hs 169248 cytochrome c 153

407078 Z26256 gb H sapiens isoform 1 gene for L-type calcium channe 152

436553 AW407157 Hs 181125 immunoglobulin lambda locus 152

443177 BE268461 Hs 202 benzodiazap e receptor (peπpheral) 152

448771 BE315511 Hs 296244 SNARE protein 152

436837 A1968248 Hs 187869 ESTs 152

423623 AB011117 Hs 129943 KIAA0545 protein 152

422651 NM 015670 Hs 118926 DKFZP586K0919 protein 152

403221 AL134878 Hs 119500 karyopheπn alpha 4 (importin alpha 3) 152

431620 AA126109 Hs 264981 2'-5'olιgoadenylate synthetase 2 152

404794 NM 000078 Hs 89538 cholesteiyl ester transfer protein, plasma 152

412944 AA384110 Hs 197143 ESTs 152

450817 N71597 Hs 29698 ESTs 152

418666 AF001434 Hs 155119 EH domain containing 1 152

451636 AW173270 Hs 140444 ESTs 152

426302 AA459085 Hs 275163 non-metastatic cells 2, protein (NM23B) expressed in 152

454485 AW795322 gb PM0 UM0018-120400-002 h01 UM0018 Homo sap 152 440617 AA894880 Hs 181181 ESTs 152

449718 AA459480 Hs 23956 hypothetical protein FU20502 152

405227 predicted exon 152

431006 BE152871 gb CM1-HT0333-101299 064-d12 HT0333 Homo sapi 152

443476 AW068594 Hs 133878 ESTs, Weakly similar to AF151889 1 CGI-131 protein 152

438828 AL134275 Hs 6434 hypothetical protein DKFZp761F2014 152

407634 AW016569 Hs 301280 ESTs, Highly similar to AF241831 1 intracellular hyalu 152

436857 AA732647 gb nz89d01 s1 NCI.CGAP.GCB1 Homo sapiens cDN 152

431526 Y10129 Hs 258742 myosm-binding protein C, cardiac 151

447386 NM.006289 Hs 18420 KIAA1027 protein 151

436573 AA723297 Hs 127138 ESTs 151

432858 BE618609 Hs 279591 Homo sapiens clone 25056 mRNA sequence 151

437352 AL353957 Hs 284181 hypothetical protein DKFZp434P0531 151

413208 AW083791 Hs 21263 Homo sapiens cDNA FLJ13152 fis, clone NT2RP3003 151

407376 AA993138 Hs 1422B7 ESTs, Weakly similar to ALUF.HUMAN »» ALU CL 151

430475 BE387420 Hs 241531 peflm 151

446764 AW291276 Hs 285532 ESTs 151

425868 AB017548 Hs 160100 Homo sapiens gene for Sepiapteπn Reductase, partial c 151

453464 AI884911 Hs 32989 receptor (calcitonin) activity modifying protein 1 151

447246 AW449032 Hs 170257 ESTs 151

401780 predicted exon 151

434063 AA018893 Hs 3727 unr-interactiπg protein 151

416114, AI695549 Hs 183868 glucuronidase, beta 151

441018 AI809587 Hs 148782 ESTs 151

425972 BE391563 Hs 165433 ESTs, Highly similar to T1 342 hypothetical protein D 151

426062 N57014 Hs 44013 ESTs 151

451234 AI914901 Hs 24052 ESTs 15 1

429565 AB020719 Hs 207802 KIAA0912 protein 151

418092 R45154 Hs 106604 ESTs 151

424550 AI650541 Hs 115298 ESTs 151

425023 AW956889 Hs 154210 endothelial differentiation, sphingolφid G-protein-coup 151

445213 AW204314 Hs 170784 ESTs 151

418102 R58958 Hs 26608 ESTs 150

450082 AI908894 Hs 245893 ESTs 150

446749 NM.016069 Hs 16089 CGI-136 protein 150

406124 predicted exon 150

457408 AL137507 Hs 255348 Homo sapiens mRNA, cDNA DKFZp761 P211 (from c 150

410051 U25773 Hs 218182 ESTs, Weakly similar to dJ1042K102 [H sapiens] 150

440965 AI523646 Hs 169859 ESTs 150

440190 AW752597 gb IL3-CT0214-161299045 B06 CT0214 Homo sapien 150

417437 U52682 Hs 82132 interferon regulatory factor 4 150

454249 AW249008 gb 28210485pπme NIH.MGC.7 Homo sapiens cDNA 150

432276 AF163302 Hs 274255 somatostatm receptor-interacting protein 150

401116 predicted exon 150

423960 AA164516 Hs 136309 CG1-61 protein 150

451661 AB020650 Hs 26777 KIAA0843 protein 150

450983 AA305384 Hs 25740 ER01 (S cerevιsιae)-lιke 150

446187 AK001241 Hs 14229 hypothetical protein FLJ 10379 150

404122 predicted exon 150

411299 BE409857 Hs 69499 hypothetical protein 150

403077 predicted exon 150

438000 AI825880 Hs 5985 non-kmase Cdc42 effector protein SPEC2 150

447118 AB014599 Hs 17411 KIAA0699 protein 150

417878 U90916 Hs 82845 Human clone 23815 mRNA sequence 150

444079 H09048 Hs 23606 ESTs 150

458234 BE551408 Hs 127196 ESTs 150

434208 T92641 Hs 127648 hypothetical protein PR02176 150

423136 AW375506 Hs 124147 ESTs 150

403177 predicted exon 150

448699 AI857269 Hs 227351 ESTs 150

425248 AW957442 Hs 252766 ESTs 150

429430 AI381837 Hs 155335 ESTs 150

TABLE 3B Pkey Unique Eos probeset identifier number

CAT number Gene cluster number Accession Genbank accession numbers

Pkey CAT Number Accession

408310 1051011 1 AW179023 AW179010

408647 1071855 1 AW245831 AW273207

408661 1073036 1 AW247625 AW249214

408987 109306 1 H85615 H86300 H86263 H86282 AA059278 H86304

409427 1129667 1 AW389668 AW389657 AW609198 AW389649

409545 1138823 1 BE296182 AW629821

409828 1155571 1 AW501137AW501295AW501212

409865 1156518 1 AW502208 AW502366 AW502148

409885 1157385 1 AW503068AW503789

410003 116761 1 AA079487 AA128547AA128291 AA079587 AA079600

410186 1182096 1 AW602528 BE073859 Z38412

410626 1212621 -1 BE407727

411004 1228975 1 AW813242BE146089 AW813195 AW813173 AW813206 BE145953 BE146212 AW813196 AW854582 AW813241 BE061582

411014 1229091 1 AW816072AW813375 AW813385 AW813372AW813436 AW816148 AW813475AW816107 AW813398 AW813479 AW814475AW813317

411028 1229404 1 AW813703 AW813839 411236 12363741 AW833752 AW833633 AW833776 AW833719 AW833362 AW833749

411420 1245222 -1 BE390652

411541 12490441 W03940 T98335 AW850705

411551 12491961 AW851309 AW850888 AW851419 AW851412 AW851299

411651 12528351 AW855392 AW855559 AW855423

411660 12530781 AW855718 AW855740 AW855748

411696 12543041 AW857404AW857401 BE144856

411811 12594271 AW864370 AW864319 AW864504

411930 12660701 F06485 AW876454

411940 1266262.1 AW876686 AW876717 AW877215 AW876691 AW876722 AW877218 AW876694 AW876725

411942 12664491 AW877015 AW877133 AW876978 AW877071 AW876988 AW877069 AW877063 AW877013

412793 1327636 -1 AW997986

413047 13468061 H02209BE062154BE062032

413101 13491541 BE065215 BE155544BE155541 BE155540 BE155542 BE155543

413154 1351077.1 BE067870 BE067866 BE165133 BE165334BE165329 BE165332

413282 1358147.1 BE078159 BE078276 BE078163 BE078277 BE078279 BE078158

413442 13705081 BE140643 BE140645 BE140644 BE140657 BE140660 BE140659 BE140661

413544 13756711 BE147225 BE147205 BE147234

413605 13797921 BE152644 BE152712 BE152668 BE152659 BE152810 BE152811 BE152816 BE152643 BE152706 BE152656 BE152660 BE152715 BE152662

BE152669 BE152661 BE152672 BE152653 BE152716 BE152651 BE152767 BE152677 BE152652 BE152714 BE152708 BE152665 BE152679

BE152771 BE152775 BE152666 BE152768 BE152813 BE152664 BE152676 BE152681 BE152709 BE152667 BE152814BE152808 BE152711

BE152707 BE152815BE152678 BE152673 BE152782 BE152671 BE152682BE152760BE152809 BE152778 BE152780BE152762BE152776

BE152781 BE152774BE152763 BE152769

413679 1382784.1 BE156765 BE156770 BE156767 BE156769 BE156803 BE156802 BE156847 BE156853 BE156780 BE156836 BE156792 BE156834 BE156779

BE156789 BE156833 BE156844 BE156831 BE156849 BE156797 BE156784 BE156801 BE156843 BE156793 BE156852

413758 1386900 -1 BE162391

414070 1414421 AW963783 F36521 F30667 AW753177 AW753195 AW853065 AA135150 AA375028

414195 1424854 -3 BE263293

414203 14255102 BE262170 BE382553 BE261026 BE273627

414266 1430984.1 BE267834 BE514180 BE514096

414276 1432115 -1 BE297862

414333 1436492.1 BE274897 BE408199 BE274723

414444 1446827 -1 BE298594

414539 14603201 BE379046 BE385459

414540 1460324 -1 BE379050

414605 1465790 -1 BE390440

414610 14660271 BE388044 BE391117 BE391530

414626 14672321 BE410589 BE390949 BE408297 BE389529

414642 1469601 AA150350 AA361174 AW959038

414663 1472628 -1 BE396326

414973 15107551 C19089 C18814 C16621

415160 15257661 T82802 D78670 R08505

415606 15404701 W70022 R35201 F12763 T74725 H63485 Z45782 H61126

415917 15615751 Z43912 H09194

416272 1584071 AA178882 AA179898 AA178897

416475 15963981 T70298 H58072 R02750

416913 1630011 AW934714 BE161007 BE162500 AW749902 AW749864 BE162498 BE161005 AA190449 AW513465 BE161006 BE162499

417112 1650681 AA193439 AA193537 AW814128

417611 1689001 AW993983 AW994798 AW993990 AW993999 AW993989 AA204755

417908 1707641 AA207221 BE538271

418636 1774021 AW749855 AA225995 AW750208 AW750206

418874 17995161 T60872 T60906

419618 1865331 AA528295 AW971284 AA247945

419889 1887981 AA251600 AA279607

420902 1975251 AA742277 AW976493 AA281585

422160 212412.1 AW582898AA305114

422731 220507.1 AL138411 AL138412AA315860

422831 2218791 R02504 AA317715 AW961465 AF121172

423050 2242881 AA320946 H92114 BE144449 BE144438

423103 2250191 AA322029 BE315237

423287 2267931 H38340 H39081 AA324112

423621 2303141 BE002904 H64880 AA328679

424585 2411511 AA464840 AA343628

424995 2457941 Z45023 AA349514

425132 2470591 AW250114 Z43124 AA431421 AI879054 AA351616 AA351035 AL048999

425612 2539691 BE004257 AW811190 AA360576 BE172402 BE181703

425798 2565861 AA364002 AI522307

426065 2602761 N32049 R34821 R78237

426356 2653811 BE536836 AA376153

426383 2661261 BE537380 BE255215

428151 2876581 AA422028 W79191

431006 3268331 BE152871 BE152870 AA490552

431257 330491 AF039597 BE243938

431614 3356681 AI189827 AW860554 AW860552 AA508543

431822 3380821 AA516049 AW004922

432966 3568391 AA650114 AW974148 AA572946

433300 3624521 AA582307 BE273018

433355 3640041 AI808235 AI024295 AA584528

433459 3668991 AA593498 AW749647 AW749630

433469 3672631 F12741 T75155AA594014

433782 374141 AF090945 AW996754 AI064870

434098 3800061 AA625499 AA625269 AA625184

435138 401159.1 BE314734 AA666393

435478 406683.1 AA682622.BE141696 436857 428068.1 AA732647 BE008970 BE009028

439078 46841 1 AF085936 H64070 H64017

439465 472721 AF086285 W69587 W69421

439848 4778061 AW979249 D63277 AA846968

440190 488021 1 AW752597 AW848781 AW849062 AW848490 AW752699 AW752604 AW752700

440669 499861 1 AI206964 AI350890 AA902772 AI768881

441552 520138.1 AA937975 F11215 BE005635

442257 536991 AW503831 AW503317 BE565665

443198 562655.1 AI039813AΪ684642 Z40121 AI951414 BE501049

443534 572957J AI076123AI244834A1695239

446052 659881 AA358760 AA158850 AW062737 AW062738 AV656291

446598 684631 AW250546 BE257108 BE251006 BE255957 BE250926 BE513012 AV659318

447224 71279.-1 BE617125

447252 7141601 R90916 AL120023 R18429 Z42095 AI369730 R90824

447383 71990.1 N24231 BE617964 N36313

447775 73665.1 BE179318 BE620044

447787 73719.1 BE620108 BE312062 AW896316 BE262546

448218 755251 AI188489 BE622201

448338 7589681 AI492857 AW070478 AI885157

448838 78409.4 BE614761 AA263136 W00335 W00327

449231 803031 BE410360 AA442408AA315540

450594 83962.1 N31036 N42915 F07753 AA010329

451400 8684591 BE160479 BE160478 BE069211 AW861059 AI793147

452544 9214671 AW851888 AW851889 AW852147

452947 9398101 AW130413AI932362 .

453758 9800261 U83527 AL120938 U83522

454163 10483691 AW175997 AW176000 AW175999 AW175994 AW176004 AW175989

454178 10494581 AW177274 AW177249 AW177223 AW177216 AW177233

454181 1049567.1 AW177377 AW177357 AW177359 AW177385 AW177358 AW177395 AW177394 AW177396 AW177383 AW177333 AW177384 AW177382

AW177360 AW177356

454209 1051071 1 AW179083 AW179085 AW179087 AW179081 AW179084 AW179086 AW179082 AW801493 AW801658 AW801714

454249 10739331 AW249008 BE295653 BE296765

454377 114761 1 AA076811 AW814764

454478 12147441 AW805749 AW805872 AW794466 AW798102 AW796921 AW794538 AW794380

454485 1215381 1 AW795322 AW795308 AW795311 AW795310 AW795314 AW795321

454505 12195641 AW801365 AW801435 AW801372

454574 12256361 AW809109 AW809112 AW809122 AW809126 AW809128 AW809133 AW809131 AW809113 AW809111 AW809132

454610 1226543.1 AW810224AW810337 AW810295AW810333 AW810335 AW810296 AW816053

454633 12275041 AW811380 AW811385

454666 12286001 AW812994 AW812723 AW812930

454803 1235520.1 AW860148 AW862380 AW821887 AW821863 AW821870 AW821894 AW862351 AW862378

454961 1246745.1 AW847807 AW847935 AW847636

455132 1254686.1 AW857955 AW861636 AW857967 AW857958 AW857943 AW857945 AW857963 AW857968 AW857959 AW857961 AW857956 BE072135

AW857972 BE072137 AW857952 AW857935 AW857940 AW857944 AW857947 AW857934

455426 12893031 AW937792 BE072250 BE072251 BE072264

455640 1348141 1 BE064059 BE063903 BE063838 BE063863 BE064056 BE063974 BE063904 BE063898 BE063896 BE063906 BE063980

455694 13506501 BE067300 BE067293 BE067279

455910 13825041 Z43712 BE156729 BE156538 BE156731 BE156673 BE156539 BE156674 BE156430 BE156672 BE156675 BE156432 BE156541

455993 13986651 BE179085 BE179084 BE179086 BE179264

456054 1452761 1 BE313241 BE383148

456329 1789807.1 T41418 T41320T41379

456394 1843275 -2 W28506

457301 3144341 AA469146 AA469396 AA469218 AA469395

458025 464091 AI275406 L23206

458606 655681 AJ239397 AV655764

458640 6700761 AI284935 AW409822 BE408182

458710 697271 AV660856 BE167375

458792 7482941 N56666AI460076

459170 9206461 AI905518 AI905516 AI905457 AI905515 AW176013 AW176037

459270 9692321 AL039604AL039497

TABLE 3C:

Pkey: Unique number corresponding to an Eos probeset

Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (Gl) numbers. "Dunham I. et al." refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, etal. (1999) Nature 402:489495

Strand: Indicates DNA strand from which exons were predicted N position: Indicates nucleotide positions of predicted exons

Pkey Ref Strand Nt position

400449 9887692 Minus 50889-51188

400613 9864507 Pius 92278-92472

400634 8567750 Minus 101102-101223,101886-102018

400642 8117693 Plus 10475-10845

400661 8118474 Plus 84912-85187

400684 8118768 Plus 58189-58323

400685 8118768 Minus 72969-73050,73713-73800

400727 6705887 Plus 106175-107016

400749 7331445 Minus 9162-9293

400807 8567878 Plus 69375-70295

400837 9188531 Plus 144778-144838,145582-145670,146656-146751,147255-147419,147682-147807

400842 1927148 Plus 90462-90673

400848 1927148 Plus 107149-107339,110873-111171

400891 9958279 Minus 140073-140427

400917 7283186 Minus 173258-173631 400931 7651921 Minus 142145-142353,144311-144721

400964 7139719 Minus 155282-155403

400965 7770576 Minus 173043-173564

400970 7960452 Minus 92744-92895

400982 8078794 Minus 119245-119471

401010 8117391 Minus 83967-84180

401072 3687273 Plus 64370-64524

401088 8492704 Plus 194659-195179

401116 9966559 Plus 123579-124447

401117 8570083 Minus 28948-29204

401167 9438381 Plus 18944-19176

401204 9743388 Minus 33694-33872

401220 9929324 Minus 48079-48279

401244 4827300 Minus 55359-56376

401245 4827300 Minus 59373-59531

401268 9797154 Plus 152272-152483,157312-157418,158025-158205,158838-158974,160716-160952

401269 8954206 Plus 2259-2591

401283 9800093 Minus 47256-47456

401373 7248205 Minus 84211-84336

401405 7768126 Minus 69276-69452,69548-69958

401465 6682292 Plus 25676-25800

401492 7341778 Plus 171020-171282,171858-172241

401521 7705251 Plus 9127-9234

401566 8469090 Minus 96277-96420,96979-97160

401575 7229804 Minus 76253-76364

401589 9966292 Plus 135969-136263

401628 8575954 Minus 210617-210796

401657 9100664 Minus 7312-8163

401747 9789672 Minus 118596-118816,119119-119244,119608-118761,120422-120990,130161-130381,130468-130593,131097-131258,131866- 131932,132451-132575,133580-134011

401757 7239630 Plus 88641-88751

401780 7249190 Minus 28397-28617,28920-29045,29135-29296,29411-29567,29705-29787,30224-30573

401781 7249190 Minus 83215-83435,83531-83656,83740-83901,84237-84393,84955-85037,86290-86814

401785 7249190 Minus 165776-165996,166189-166314,166408-166569,167112-167268,167387-167469,168634-168942

401789 7249213 Minus 70399-70629,70941-71055

401809 7342191 Minus 107548-108298

401847 7139731 Plus 85447-85593

401887 7229981 Plus 93973-94120

401913 9369520 Minus 33753-33904

401962 3176728 Minus 71433-71648,76711-76833,78677-78845,79585-79763,8234982485

401991 4156128 Plus 2398-2513

401984 4153858 Minus 42904-43124,43211-43336,44607-44763,45199-45281,46337-46732

402023 7528158 Minus 132872-133040

402066 6649269 Plus 135543-136031

402071 8117361 Plus 85924-86039

402075 8117407 Plus 121907-122035,122804-122921,124019-124161,124455-124610,125672-126076

402131 7704961 Minus 33114-33209,33496-33678

402144 7242326 Plus 115425-115977

402203 8576119 Minus 8124-8285

402277 2894631 Plus 16980-17152,17933-18018,18170-18306

402282 2447220 Plus 33880-34029,34176-34336,34953-35103

402287 6598824 Plus 35279-35405,35573-35659

402407 3962498 Minus 115812-116187

402421 9796341 Minus 46609-46662,46758-46811,86293-86346,89776-89829,90048-90101,102817-102924

402427 9796372 Plus 16266-16431

402430 9796372 Minus 62382-62552

402520 7596899 Minus 171761-171996

402538 9801137 Minus 96314-96539

402543 9838066 Minus 89684-90893

402570 9884747 Minus 12649-12866

402585 9908890 Minus 174893-175050,183210-183435

402639 9958129 Minus 20167-22383

402694 8569867 Plus 2218-2440

402699 8570304 Minus 182773-182883,184551-184732

402738 7331557 Minus 8725-8859

402855 9662953 Minus 59763-59909

402869 6434643 Minus 138639-139335

402939 9187334 Minus 18329-18535

402944 9368423 Plus 110411-110716,111173-111640

402948 9368458 Minus 143456-143626,143808-143935

402958 9368493 Plus 13324-13507

403010 3132346 Plus 78385-79052

403036 3132360 Plus 66545-66712

403051 4827080 Minus 5269-5411

403065 8954197 Minus 71615-71773,73930-74144

403077 8954241 Plus 146923-147222,147326-147628

403093 8954241 Plus 177083-177373,177464-177751

403151 7407965 Minus 14055-14264

403153 9799871 Minus 42232-43389

403177 9838213 Minus 142560-142726

403223 7630969 Plus 81529-81692

403234 7637801 Plus 180641-180822

403273 8018055 Plus 133809-134099

403286 8080320 Plus 118369-118872 403287 8080320 Minus 126097-126411

403348 7239527 Plus 13809-13968

403359 8570207 Minus 108939-109229

403362 8571772 Plus 64099-64260

403447 9837821 Minus 159072-159387

403508 7630896 Plus 5570-5719

403582 8101186 Plus 18308-18458

403613 8493504 Plus 81290-81465

403642 8699671 Plus 7062-7311

403662 5823349 Plus 58627-59062,59222-59548

403674 7321642 Plus 104988-105623,107394-107590

403687 7387384 Plus 9009-9534

403695 3046276 Plus 168272-168514

403703 4966380 Plus 83681-84042

403741 7630932 Minus 2833-3468

403747 7658395 Minus 20493-20621

403766 7229888 Plus 136283-136830

403786 8083636 Minus 73028-73217

403796 8099896 Minus 75073-77664

403833 887461 Plus 13522-13664

403852 7708872 Minus 124007-124202

403861 7708966 Plus 58363-58649

403912 7710730 Minus 72000-72290,72431-72700,72929-73199

403924 7711688 Minus 89369-89592

403964 7596976 Plus 178174-178300

404034 8567760 Minus 44635-47010 '

404067 3282162 Plus 1415-2071

404097 7770701 Plus 55512-55781

404122 9796270 Plus 90540-92977

404230 7981448 Minus 92934-93093

404239 5002624 Plus 94841-95095

404240 5002624 Minus 116132-116407,116653-116922

404270 9828129 Minus 3649-3750,4161-4306,5962-6049,6849-6965

404356 7630858 Minus 126433-126623

404600 8705107 Plus 118354-118444,118649-118792

404601 8705107 Plus 128449-128693,129085-129249,130525-130733

404638 9796751 Minus 99433-99528,100035-100161

404666 7272179 Minus 18677-18993

404675 9797204 Minus 48532-48645,49808-49975,51088-51369,54944-55063

404727 8081050 Plus 115534-115747

404750 7596836 Plus 181879-182198

404763 7882612 Plus 50981-51392

404767 7882827 Minus 23244-23759

404828 6580415 Minus 26291-27253

404850 5420148 Minus 35145-35413,40635-41062

404881 5931510 Minus 36360-36608

404890 7329390 Plus 101280-101408

404971 3212939 Minus 74585-75532

405022 7330304 Plus 217163-217439

405028 7533974 Minus 110588-110847,110933-111115

405071 7708797 Minus 11115-11552

405088 8072518 Minus 115690-117621

405133 8516055 Minus 28127-28288

405138 8576241 Plus 90303-90516

405183 7209940 Plus 12335-12653

405194 7230072 Plus 190465-190645,193346-193610

405196 7230083 Minus 135716-135851

405208 7230142 Plus 8068-8214

405226 7248966 Plus 53547-54128

405227 6731245 Minus 22550-22802

405256 7329310 Plus 26070-26309

405277 3980473 Plus 23471-23572

405307 3638954 Plus 39195-39429

405311 3638954 Plus 46313-46496

405333 3165399 Plus 149905-150215

405411 3451356 Minus 17503-17778,18021-18290

405423 4753276 Plus 6162-6983

405491 5801645 Plus 81857-82045

405501 9211311 Minus 49085-49400,49565-49679,50117-50262

405515 9454624 Plus 37329-37469

405545 1054740 Plus 118677-118807,119091-119296,121626-121823

405580 4512267 Plus 169232-169647

405586 5002511 Plus 38810-39017

405600 5923640 Plus 26662-27225

405610 5757553 Minus 71907-72080

405639 5091650 Plus 211184-211350

405687 6249668 Minus 54787-54891,55844-55917

405699 4165331 Plus 100727-100859

405783 5738434 Minus 27238-27885

405867 6758731 Minus 74553-75173

406086 7107817 Plus 9418-9573

406124 9149714 Minus 1331-1774

406130 9161404 Minus 32394-32498

406140 9168231 Minus 49887-50219 406160 7144945 Plus 55498-56268

406207 5923650 Minus 162607-162800

406215 7342161 Plus 310-432

406268 6682695 Minus 6605-7072

406277 5686030 Minus 4759-5490

406326 9212385 Plus 84508-84655

406388 9256205 Plus 85153-85277

406457 9755793 Plus 44966-45406

406473 9795566 Minus 109669-109831

406537 7711478 Plus 32804-33017

406571 7711622 Minus 65634-65912,66116-66596

406580 7711838 Minus 96654-97640

TABLE 4A lists about 131 genes up-regulated in ovanan cancer compared to normal ovanes that are likely to be exfracellular or cell-surface proteins These were selected as for Table 3A, except that the raho was greater than or equal to 10, and the predicted protein contained a PFAM domain that is indicitive of extracellular localization

TABLE 4A ABOUT131 UP-REGULATED GENES ENCODING EXTRACELLULAR/CELL SURFACE PROTEINS, OVARIAN CANCER VERSUS NORMAL OVARY

Pkey Pπmekey

Ex Accn Exemplar Accession

UG ID UπiGene lD

Title Unigene Title

PFAM domains ratio tumor vs normal ovary

Pkey Ex Accn UG ID Title PFAM ratio

403077 predicted exon fn3 15 0

426535 AU077012 Hs 288582 ESTs, Weakly similar to ubiquitous TP Kunitz BPTI 149

403089 predicted exon fn3 14 9

457148 AF091035 Hs 184627 KIAA0118 protein arf.ras 148

431176 AI026984 Hs 293662 ESTs laminin.EGF.Iammin.B, 148

434293 NM.004445 Hs 3796 EphB6 fn3 pk ase.EPHJbd 148

408482 NM 000676 Hs 45743 adenosme A2b receptor 7tm_1 146

428695 AI355647 Hs 189999 puπnergic receptor (family A group 5) 7tm 1 145

426125 X87241 Hs 166994 FAT tumor suppressor (Drosophila) ho EGF 144

423732 AF058056 Hs 132183 solute earner family 16 (monocarboxy sugar.tr.MCT 143

422125 NM.003459 Hs 111967 solute earner family 30 (zinc traπsporte Cation efflux 142

407483 NM.012368 (NONE) 7tm_1 142

446689 AW594695 Hs 167046 ESTs 7tm_1 14 1

410184 AW503667 Hs 59545 πng finger protein 15 zf C3HC4,SPRY,zf-B_box 140

423217 NM 000094 Hs 1640 collagen, type VII, alpha 1 (epidermoly fn3,vwa 140

405448 AI015709 Hs 172089 Homo sapiens mRNA, cDNA DKFZpδ trypsin sushi.CUB 140

450684 AA872605 Hs 25333 interleukm 1 receptor, type II 140

406692 136607 gb Homo sapiens (clone 22) pregnancy 139

425549 U64863 Hs 158297 programmed cell death 1 13 8

452755 AW138937 Hs 213436 ESTs cystatin 13 8

427637 AK000816 Hs 179986 flotillm 1 Baπd_7 137

424591 R55704 Hs 150968 hypocretin (orexm) receptor 1 7tm_1 137

405024 predicted exon TGF-beta,TGFb propeptide 137

405285 predicted exon A2M.A2M.N 137

412116 AW402166 Hs 784 Epstein-Barr virus induced gene 2 (lym 7tm_1 137

420256 U84722 Hs 76206 cadheπn 5, type 2, VE-cadheπn (vascu cadheπn.Cadheππ.CJerm 13 6

420511 AF052692 Hs 98485 gap junction protein, beta 4 (connexin 3 connexin 13 5

448638 R17122 Hs 21639 nuclear protein, marker for differential 134

431117 AF003522 Hs 250500 delta (Drosophila) like 1 EGF.DSL 134

439285 AL133916 Hs 298998 ESTs ιg,pkιnase,LRRNT,LRRCT 134

424283 AA338246 Hs 301678 ESTs E1-E2_ATPase,Hydrolase 133

436233 AI742878 Hs 124116 ESTs 133

443859 NM 013409 Hs 9914 follistatin kazal 13 2

410016 AA297877 Hs 57907 small inducible cytokine subfamily A ( IL8 13 2

414020 NM.002984 Hs 75703 small inducible cytokine A4 (homologo IL8 13 2

400242 predicted exon Ephπn 130

429057 AF156557 Hs 194816 stomatin-like protein 1 Band_7,SCP2 129

438294 AI693753 Hs 143004 ESTs E1-E2 ATPase.Hydrolase 129

458493 AV649408 Hs 282418 ESTs RYDRJTPR 128

444181 AB033063 Hs 10491 KIAA1237 protein fn3,ιg,PH,RhoGEF 128

422357 AF016272 Hs 115418 cadheπn 16, KSP-cadheπn cadheπn 127

409632 W74001 Hs 55279 seπne (or cysteine) protemase inhibitor serpm 127

407000 U12139 gb Human alphal(XI) collagen (COL1 TSPN,Collagen,COLFI 126

417064 W02903 Hs 15440 ESTs lectm.c 126

439389 AA318940 Hs 56004 ESTs hemopexιn,Peptιdase_M10 126

407786 AA687538 Hs 38972 tefraspan 1 transmembraπe4 125

410498 AA355749 gb EST64459 Jurkat T-cells VI Homo aa_permeases 125

422487 AJ010901 Hs 198267 mucin 4, tracheobronchial vwd 125

422330 D30783 Hs 115263 epiregulm EGF 125

402425 predicted exon lonjrans 124

414875 H42679 Hs 77522 major histocompatibility complex, clas 122

424239 M67439 Hs 143526 dopamme receptor D5 7tm_1 122

442622 NM.000435 Hs 8546 Notch (Drosophila) homolog 3 EGF,ank,πotch 122

405368 predicted exon 7tm_1 122

402406 predicted exon Gal bind.lectin 121

426514 BE616633 Hs 301122 bone orphogenetic protein 7 (osteoge TGF-beta,TGFb_propeptιde 12 1

406811 U82979 Hs 67846 leukocyte immunoglobulin-like recepto 120

416441 BE407197 gb 601301552F1 NIH.MGC.21 Homo SDF 120 433221 AB040917 Hs 97860 KIAA1484 protein fn3,ιg,LRRCT 11 9

442915 AA852875 Hs 8850 a dismtegπn and metalloprotemase dom disintegπn.Reprolysm, 11 9

423613 AF036035 Hs 129910 hyaluronoglucosamimdase 3 ig.Sema.Acetylfransf 11 9

411213 AA676939 Hs 69285 neurapilin 1 CUB,MAM,F5_F8_type_C 11 9

425483 AF231022 Hs 301273 Homo sapiens protocadhenπ Fat 2 (FA EGF,cadheπn,lamιnιn G 11 8

421258 AA286731 gb zs53d08 r1 NCI CGAP GCB1 Horn 7tm_3 11 8

423795 AW849759 gb IL3-CT0216-240200-077-C04 CTO arf.ras 11 7

422424 AI186431 Hs 116577 prostate differentiation factor TGF-beta 11 7

443296 AI765286 gb wι73b05 x1 NCI_CGAP_Kιd12 Ho ig 11 7

448999 AF179274 Hs 22791 transmembrane protein with EGF-like kazal 11 7

414878 AA341040 Hs 77541 ADP-πbosylation factor 5 arf.ras 11 5

429344 R94038 Hs 199538 inhibm, beta C TGF-beta 11 5

402114 predicted exon laminin EGF.Iaminm G 11 5

419216 AU076718 Hs 164021 small inducible cytokine subfamily B ( IL8 11 5

430263 D12614 Hs 36 lyphotoxin alpha (TNF superfamily, m TNF 11 4

400464 predicted exon Peptιdase_S9 11 4

456841 AA875863 Hs 152345 poliovirus receptor-related 1 (herpesvir ig 11 4

409420 Z15008 Hs 54451 laminin, gamma 2 (nice (100kD), kal laminin.EGF.Iamimn.B 11 4

418043 AW377752 Hs 83341 H sapiens mRNA for tyrosine kinase re frι3,ιg,pkιnase 11 3

426523 S68616 Hs 170222 solute earner family 9 (sodium/hydrog Na_H_Exchanger 11 3

446051 BE048061 Hs 153315 ESTs Reprolysiπ.dismtegπn 11 3

439710 AF086543 gb Homo sapiens full length insert cDN Xlink 11 3

416602 NM 006159 Hs 79389 nel (chicken) like 2 vwc.TSPN 11 3

418299 AA279530 Hs 83968 integπn, beta 2 (antigen CD18 (p95), ly iπtegπn.B 11 3

425721 AC002115 Hs 159309 uroplakin 1A, fransmembrane4,C0X6B,Ets 11 2

409757 NM 001898 Hs 123114 cystatin SN cystatin 11 2

430630 AW269920 Hs 2621 cystatin A (stefin A) 7tm_3,ANF_receptor 11 2

429630 M85289 Hs 211573 heparan sulfate proteoglycan 2 (perieca laminin EGF.ig.ldl recep a 11 1

427289 AI097346 Hs 174203 solute earner family 1 (glutamate/neutr SDF 11 1

401248 AB028989 Hs 88500 mitogen-activated protein kinase 8 te vwa.vwd.TIL 11 1

412627 BE391959 Hs 74276 chloπde intracellular channel 1 G-patch,ιg,MutS C 11 1

420104 U09825 Hs 1287 zinc finger protein 173 zf-C3HC4,SPRY,zf-B_box 11 1

405275 AB028989 Hs 88500 mitogen-activated protein kinase 8 te vwa,vwd,TIL 11 1

425864 U56420 Hs 159903 olfactory receptor, family 5, subfamily 7tm_1 11 1

446745 AW118189 Hs 156400 ESTs vwa 11 1

441834 AL138034 Hs 7979 KIAA0736 gene product sugar.tr 11 0

450986 BE241845 Hs 25744 Novel human gene mapping to chomos PH.RhoGAP.Gal-bindJectin 11 0

416118 N52773 Hs 167721 ESTs hemopexιn,Peptιdase_M10 11 0

443071 AL080021 Hs 8986 complement component 1, q subcompo C1q,Collagen 109

431247 AL021578 Hs 278489 matnlin 4 EGF.vwa 109

431449 M55994 Hs 256278 tumor necrosis factor receptor superfam TNFR.C6 10 9

457044 S73899 Hs 2131 arginine vasopressin receptor 1 A 7tm_1 109

416319 AI815601 Hs 79197 CD83 antigen (activated B lymphocyte i 108

402172 predicted exon ig 107

424218 AF031824 Hs 143212 cystatin F (leukocystatin) cystatin 106

409208 Y00093 Hs 51077 mtegπn, alpha X (antigen CD11 C (p15 vwa 106

426330 M77235 Hs 169331 sodium channel, voltage-gated, typeV, lon.trans.lQ 10 6

439758 AA845235 Hs 124470 ESTs transmembrane4 106

412429 AV650262 Hs 75765 GR02 oncogene IL8 106

449987 AW079749 Hs 184719 ESTs, Weakly similar to AF116721 11 ABC.tran.ABC.membrane 106

432408 N39127 Hs 76391 myxovirus (influenza) resistance 1, horn ion trans.KJetra 106

406672 M26041 Hs 198253 major histocompatibility complex, das ιg,MHC_ll_alpha 105

419749 X73608 Hs 93029 sparc/osteonectin, cwcv and kazal-like kazal,thyroglobuIιn_1 105

419086 NM 000216 Hs 89591 Kallmaπn syndrome 1 sequence frι3,wap 10 5

425009 X58288 Hs 154151 protein tyrosine phosphatase, receptor t frι3,ιg,Y_phosphatase,MAM 105

423869 BE409301 Hs 134012 C1q-related factor GTP.EFTU.EFG.C 104

430209 AF177941 Hs 235368 Pro-(alpha)3(V) collagen Collagen.COLFI.TSPN 104

400834 predicted exon IRK 104

442941 AU076728 Hs 8867 cysteine-πch, aπgiogenic inducer, 61 Cys_kπot,tsp_1,vwc,IGFBP 104

403691 predicted exon tsp_1,Reprolysιn, 104

430776 AJ011021 Hs 247905 potassium voltage-gated channel, subfa lon.trans 103

432342 AL036128 Hs 274404 plasmmogen activator, tissue EGF,fn1,kπngle,trypsιn 103

413731 BE243845 Hs 75511 connective tissue growth factor Cys knot,tsp 1,vwc 10 3

423309 BE006775 Hs 126782 sushi-repeat protein sushι,HYR 103

431728 NM.007351 Hs 268107 multimeπn EGF,C1q 103

450245 AA007536 Hs 271767 ESTs, Moderately similar to ALU1.HU ig 102

446983 AA157484 Hs 97199 complement component C1q receptor EGF,Xlιπk 10 2

414320 U13616 Hs 75893 ankyπn 3, node of Ranvier (ankyπn G) death,ank,ZU5 101

400253 predicted exon 7tm_1 100

406694 M94891 Hs 225932 pregnancy specific beta-1 -glycoprotein ig 100

418793 AW382987 Hs 88474 prostaglandin endoperoxide synthase 1 EGF 100

410664 NM 006033 Hs 65370 lipase, endothelial Rιbosomal_L22 100

427274 NM 005211 Hs 174142 colony stimulating factor 1 receptor, fo pkinase.ig 100

TABLE 4B

Pkey Unique Eos probeset identifier number CAT number Gene cluster number Accession Genbank accession numbers

Pkey CAT Number Accession

410498 120611.1 AA355749AA085520AW966333AA340319 BE170936

416441 159480.1 BE407197 AA182474AA180369 BE275628 BE276131

421258 200725.1 AA286731 AA287621 AW188228 AW137774

423795 232093 1 AW849759 AW849758 T89549 AA331069 439710 475501 AF086543 W96291 W96225 443296 56539.2 AI765286 AW297086 BE568658

TABLE4C

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham I et al " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (19991 Nature 402489-495 Strand Indicates DNA strand from which exons were predicted N position Indicates nucleotide positions of predicted exons

Pkey Ref Strand Nt position

400464 9929670 Plus 22074-22214

400834 8705192 Plus 121963-122288

402114 8318586 Plus 71578-71715

402172 8575911 Minus 143378-143671

402406 3970929 Plus 10872-11123,12932-13048

402425 9796347 Minus 50224-50395

403077 8954241 Plus 146923-147222,147326-147628

403089 8954241 Plus 171964-172239

403691 7387384 Minus 88280-88463

405024 7107727 Plus 88500-88697

405285 6139075 Minus 55744-55903,57080-57170,61478 61560

405368 2104517 Plus 46055-47188

TABLE 5A lists about 685 genes down-regulated in ovanan cancer compared to normal ovaries These were selected as for Table 3A, except that the numerator and denominator were switched, and the ratio was greater than or equal to 30 (i e 3-fold down regulated in tumor vs normal ovary)

TABLE 5A 685 DOWN-REGULATED GENES, OVARIAN CANCER VERSUS NORMAL OVARY

Pkey Pπmekey

Ex Accn Exemplar Accession

UG ID UniGene lD

Title UniGene Title ratio ration normal ovary vs tumor

Pkey Ex Accn UG ID Title ratio

421013 M62397 Hs 1345 mutated in colorectal cancers 148

439360 AA448488 Hs 55346 ESTs, Weakly similar to Z141.HUMAN ZINC FINGE 128

407644 D16815 Hs 37288 nuclear receptor subfamily 1 , group D, member 2 126

424851 AA676441 Hs 119059 ESTs 11 6

455056 AW853057 gb RC1-CT0249-170200 025-h04 CT0249 Homo sapie 11 5

420727 H75701 Hs 99886 complement component 4-bιndιng protein, beta 11 3

451617 C01056 Hs 168000 ESTs 100

401308 predicted exon 99

440987 AA911705 Hs 130229 ESTs 97

409725 T40760 Hs 90459 EST 97

415752 BE314524 Hs 78776 putative transmembrane protein 97

437690 AA804362 Hs 180544 ESTs 96

437787 AI908263 Hs 291625 ESTs 95

459054 AW798466 Hs 82396 2',5'-oIιgoadenylate synthetase 1 92

435330 R16769 Hs 185689 ESTs 92

436642 AA724430 Hs 127960 ESTs 9 1

453752 AL120800 gb DKFZp762E152 r1 762 (synonym hmel2) Homo sa 9 1

451683 AI808964 Hs 207673 ESTs 9 1

401464 AF039241 Hs 9028 histone deacetylase 5 90

436812 AW298067 gb UI-H-BWO-ajp-g-09-O-UI s1 NCI CGAP_Sub6 Hom 87

410758 8E535988 gb 601062418F1 NIH MGC 10 Homo sapiens cDN A 87

412637 AA115097 Hs 261313 ESTs 84

419166 AA234638 Hs 293584 ESTs 83

423739 AA398155 Hs 97600 ESTs 81

413813 M96956 Hs 75561 teratocarcinoma-deπved growth factor 1 8 1

416211 R14625 gb yg45c03 r1 Soares infant brain 1 NIB Homo sapiens 80

443131 AI033833 Hs 132689 ESTs 79

415866 T10115 Hs 92423 KIAA1566 protein 79

410130 AI912097 Hs 163208 ESTs 79

439426 AI131502 Hs 143135 ESTs, Weakly similar to FAFY.HUMAN PROBABLE 78

408141 U69205 Hs 45152 ESTs, Moderately similar to neurogenic basic-he x-loop 77

419015 T79262 Hs 14463 ESTs 76

441573 BE563966 Hs 6529 ESTs 75

419386 AA236867 Hs 143868 ESTs 75

430562 D78260 Hs 285097 ESTs 75

434738 AA836265 gb od17e02 s1 NCI_CGAP_GCB1 Homo sapiens cDNA 74

403283 predicted exon 74

415861 Z43123 Hs 144513 ESTs 74

412732 AW993300 gb RC2-BN0033-180200-015-g06 BN0033 Homo sapie 74

441247 AW118681 Hs 128051 ESTs 74

442865 N57659 Hs 114541 ESTs, Weakly similarto neuronal thread protein AD7c- 73

409699 BE154650 gb PM3-HT0344-071299 003-C08 HT0344 Homo sapie 73

420352 BE258835 gb 601117374F1 NIH.MGC.16 Homo sapiens cDNA 73

421418 AA806639 gb ob88g05 s1 NCI.CGAP.GCB1 Homo sapiens cDN 72

413597 AW302885 Hs 117183 ESTs 72

454102 AW752363 gb RC0-CT0201-270999 011-103 CT0201 Homo sapien 71

445487 AI806287 Hs 201217 ESTs 71

457604 AI004397 Hs 130558 ESTs, Weakly similar to similar to 0-sιaloglycoproteιn 71 400942 predicted exon 69

407596 R86913 gb yq30f05 r1 Soares fetal liver spleen 1NFLS Homo sa 69

422046 AI638562 gb ts50a10 x1 NCI CGAP Ut1 Homo sapiens cDNA c 69

441284 AA927676 Hs 196542 ESTs 69

446224 AW450551 Hs 13308 ESTs 69

424943 AU077260 Hs 153924 death-associated protein kinase 1 69

453967 AW009077 Hs 232947 ESTs 69

448683 AA167642 Hs 14632 ESTs 68

431877 AA521204 Hs 105507 ESTs 68

411337 AW837349 gb QV2-LT0038-270300-108- 12 LT0038 Homo sapie 68

410596 AA374186 gb EST86290 HSC172 cells 1 Homo sapiens cDNA 5' e 68

417762 AA205976 gb zq48a10 r1 Stratagene hNT neuron (937233) Homo 67

406364 predicted exon 67

452238 F01811 Hs 187931 ESTs, Moderately similar to S22703 voltage-gated pota 67

415288 R15794 Hs 141027 ESTs, Weakly similar to ALU1.HUMAN ALU SUBFA 67

407437 AF220264 gb Homo sapiens MOST-1 mRNA, complete eds 67

439126 AF085984 gb Homo sapiens full length insert cDNA clone YT99F 66

452453 AI902519 gb QV-BT009-101198-051 BT009 Homo sapiens cDNA 66

431800 AW452768 Hs 162045 ESTs 65

426380 AI291267 Hs 149990 ESTs, Weakly similar to unnamed protein product [H sa 65

449529 AI990559 Hs 232033 ESTs 64

437755 AW204256 Hs 291887 ESTs 64

448307 AI480289 Hs 211026 ESTs 64

439586 AA922936 Hs 110039 ESTs 64

420051 N35696 Hs 44745 ESTs 64

425806 AI522299 Hs 173369 ESTs 64

433923 AI823453 Hs 146625 ESTs 64

408159 H63977 Hs 118526 ESTs 63

434844 AF157116 Hs 301355 hypothetical protein LOC56757 63

430197 AA468888 Hs 187697 ESTs, Weakly similar to ALU5 HUMAN ALU SUBFA 63

440332 AI218517 Hs 188051 ESTs 63

450061 AI797034 Hs 201115 ESTs 63

454994 AW850176 gb IL3-CT0219-271099-022-H04 CT0219 Homo sapien 63

402105 predicted exon 63

409090 W56067 Hs 103105 ESTs 62

405752 predicted exon 62

408074 R20723 Hs 124764 ESTs 62

459200 Y09306 Hs 30148 homeodomain-iπteracting protein kinase 3 6 1

416310 T81421 Hs 221396 ESTs 6 1

421976 AL138443 Hs 23450 mRNA for FLJ 00023 protein 61

429755 NM 001364 Hs 215839 discs, large (Drosophila) homolog 2 (chapsyn 110) 60

448732 BE614063 gb 601503993F1 NIH MGC 71 Homo sapiens cDNA 60

453909 AW004045 Hs 203365 ESTs 60

431178 AA493884 Hs 218008 Homo sapiens cDNA FLJ21440 fis, clone COL04389 60

449671 AW959755 Hs 288896 Homo sapiens cDNA FLJ12977 fis, clone NT2RP20062 60

421349 W01715 Hs 102958 ESTs, Weakly similar to Lpg6p [S cerevisiae] 60

453282 AK000043 Hs 32922 hypothetical protein FLJ20036 59

420618 AA278781 Hs 280698 ESTs 59

412480 BE142364 gb CM0-HT0143-270999 062-d12 HT0143 Homo sapi 59

449858 AW205979 Hs 196065 ESTs 59

429884 AL049925 Hs 225984 DKFZP547G0910 protein 59

416453 H56968 Hs 114593 ESTs 59

459497 AA825742 Hs 87517 ESTs 59

433773 AA759293 Hs 112692 ESTs 59

458942 AA009647 Hs 8850 a disintegπn and metalloprotemase domain 12 (meltπn a 59

436054 AI076262 Hs 119813 ESTs 59

410495 N95428 gb zb80d09 s1 Soares_senescent_fibroblasts_NbHSF H 58

403277 predicted exon 58

444302 AI140115 Hs 225130 ESTs 58

439834 AI754576 Hs 124523 ESTs 58

404020 predicted exon 58

454338 AW381251 Hs 1050 pleckstππ homology, Sec7 and coiled/coil domains 1(cy 57

430922 AW373747 Hs 183337 ESTs 57

420289 N55394 Hs 96398 8-oxoguanιne DNAglycosylase 57

428498 AA429575 Hs 243032 ESTs 57

445597 H65649 gb yr72d10 r1 Soares fetal liver spleen 1NFLS Homo sa 57

411543 AW851248 gb IL3-CT0220-160200-066-F01 CT0220 Homo sapien 57

408354 AI382803 Hs 159235 ESTs 57

444431 AW513324 Hs 42280 ESTs 57

406605 predicted exon 57

405541 AF039241 Hs 9028 histoπe deacetylase 5 56

458090 AI282149 Hs 56213 ESTs, Highly similarto FXD3 HUMAN FORKHEAD 56

454529 Z45439 Hs 270425 ESTs 56

445832 AI261545 gb qz30a07 x1 NCI CGAP Kιd11 Homo sapiens cDNA 56

441223 AI475067 Hs 132499 ESTs 56

432552 AI537170 Hs 173725 ESTs, Weakly similarto ALU8 HUMAN ALU SUBFA 56

443650 AI698330 Hs 151444 ESTs 56

403714 predicted exon 56

444165 AL137443 Hs 10441 hypothetical protein FU11236 56

458914 BE327696 Hs 280922 ESTs 56

420620 AA278807 Hs 173343 ESTs 55

458228 AA934995 Hs 184846 ESTs, Weakly similar to R28830 1 [H sapiens] 55

448067 R68568 Hs 183373 src homology 3 domain-containing protein HIP-55 55

427000 AI187420 Hs 145221 ESTs 55 452351 AA025647 gb ze85d01 r1 Soares_fetal_heart_NbHH19W Homo sa 55

459359 N99545 gb za40a05 r1 Soares fetal liver spleen 1 NFLS Homo sa 55

408385 AF055634 Hs 44553 unc5 (C elegans homolog) c 55

450938 AW753734 Hs 277215 ESTs 55

431888 H99557 Hs 2864 eariy endosome antigen 1, 162kD 54

459418 W96550 Hs 26418 ESTs 54

416718 R83017 Hs 204828 ESTs 54

413236 H16442 Hs 127376 KIAA0266 gene product 54

439063 AF085922 Hs 113968 ESTs 54

446361 AI291234 Hs 282241 ESTs 54

458253 AW296952 Hs 196802 ESTs 54

433682 AA642418 Hs 17381 ESTs 54

455790 BE090690 gb RC1 -BT0720-280300-011 -g02 BT0720 Homo sapie 54

445755 AW294870 Hs 223672 ESTs 53

436513 AJ278110 Hs 125507 DEAD-box protein 53

416671 N94087 Hs 26073 ESTs, Moderately similar to HG14 HUMAN NONHIS 53

440231 AW015420 Hs 163323 ESTs 53

429866 AA460104 Hs 99540 ESTs 53

437779 AA345232 Hs 21227 ESTs 53

424029 AB014594 Hs 137579 KIAA0694 gene product 53

425614 AI334963 Hs 156256 ESTs 53

430653 AW902062 Hs 30280 ESTs 52

408855 T83061 Hs 279604 desmin 52

410454 AW749041 gb RC3-BT0319-100100 012-C05 BT0319 Homo sapie 52

438116 AI904105 Hs 122016 ESTs 52

409138 W73159 Hs 58290 ESTs 52

423047 NM 005323 Hs 123064 H1 histone family, member T (testis-specific) 52

440212 AW300959 Hs 126216 ESTs, Weakly similar to good similaπty to E coli hypo 52

404108 predicted exon 52

456253 T12198 gb A588F Heart Homo sapiens cDNA clone A588, mRN 52

409365 AA702376 Hs 226440 Homo sapiens clone 24881 mRNA sequence 5 1

444013 T08531 Hs 44404 hypothetical protein PR01488 5 1

454071 AI041793 Hs 42502 ESTs 5 1

419761 M17373 Hs 93177 interferon, beta 1, fibroblast 5 1

451250 AA491275 Hs 236940 Homo sapiens cDNA FLJ12542 fis, clone NT2RM4000 5 1

405290 predicted exon 51

454487 AW796342 gb PM2-UM0027-230200 002-h02 UM0027 Homo sap 5 1

444131 AI806600 Hs 207119 EST, Weakly similar to intrinsic factor-B12 receptor pr 5 1

441679 BE502267 Hs 65996 ESTs 5 1

450077 AA523752 Hs 120855 ESTs 5 1

421209 AJ010230 Hs 102576 ret finger protein-like 1 antisense 51

445140 AI650599 Hs 197913 ESTs 5 1

421126 M74587 Hs 102122 insulin like growth factor binding protein 1 5 1

447037 AI357568 Hs 157612 ESTs 5 1

407168 R45175 gb yg40f01 s1 Soares infant brain 1 NIB Homo sapiens 50

436196 AK001084 gb Homo sapiens cDNA FLJ10222 fis, clone HEMBB1 50

442772 AW503680 Hs 300513 ESTs, Weakly similar to T15B72 [C elegans] 50

444138 AI701572 Hs 151153 ESTs 50

458589 AV654623 Hs 288141 Homo sapiens cDNA FU13016 fis, clone NT2RP30006 50

451640 AA195601 Hs 26771 Human DNA sequence from clone 747H23 on chromos 50

441318 AI078234 Hs 176130 ESTs 50

407490 S79281 gb pancreatic πbonuclease [human, mRNA Recombman 49

438224 AA933999 gb on91f04 s1 Soares_NFL_T_GBC_S1 Homo sapiens 49

451638 AW798466 Hs 82396 2',5'-olιgoadenylate synthetase 1 49

457356 AA489621 Hs 191670 ESTs 49

430679 R44428 Hs 22801 ESTs 49

445747 AI820863 Hs 145328 ESTs, Weakly similar to ALU1 HUMAN ALU SUBFA 49

409036 T88693 Hs 226410 ESTs 49

433382 T64293 Hs 291453 ESTs 49

401287 predicted exon 49

424188 AW954552 Hs 142634 zinc finger protein 49

404868 predicted exon 49

410152 AW593104 Hs 23681 ESTs 49

444997 AI204451 Hs 146196 ESTs 49

431075 BE267477 gb 601189542F2 NIH.MGC.7 Homo sapiens cDNA cl 48

429033 NM.007374 Hs 194756 sine oculis homeobox (Drosophila) homolog 6 48

414337 BE386606 gb 601273980F1 NIH.MGC.20 Homo sapiens cDNA 48

410336 BE391510 Hs 18498 Homo sapiens cDNA FU12277 fis, clone MAMMA10 48

445283 AW515763 Hs 246872 ESTs 48

434792 AA649253 Hs 132458 ESTs 48

433403 AF040247 gb Homo sapiens erythroid differentiation-related factor 48

454940 AW846202 gb QV0-CT0179-011299 061-flO CT0179 Homo sapie 48

455534 AW991925 gb PM3-BN0011-130100-002-b07 BN0011 Homo sapi 48

416437 N48990 Hs 37204 ESTs 48

433767 AA609245 gb af13a11 s1 Soares tests NHT Homo sapiens cDNA 48

434977 AI734233 Hs 226142 ESTs, Weakly similar to ALU7.HUMAN ALU SUBFA 48

416192 NM 005036 Hs 998 peroxisome proliferative activated receptor, alpha 48

459218 AA812633 Hs 10845 ESTs 48

402109 predicted exon 48

444490 AI151080 Hs 146830 ESTs 48

432632 AW973801 Hs 134656 ESTs 48

438683 AA813982 Hs 291842 ESTs 48

404044 predicted exon 48

449862 AI672277 Hs 199475 ESTs 48 419002 T78625 Hs.268594 ESTs 4.7

425582 AL157686 Hs.293737 ESTs 4.7

416086 H18252 Hs.227263 ESTs 4.7

441133 AA918191 Hs.194457 ESTs 4.7

446323 AI288274 Hs.149868 ESTs . 4.7

440347 AI125590 Hs.142864 ESTs 4.7

439481 AF086294 Hs.125844 ESTs 4.6

456388 W28557 gb:48d8 Human retina cDNA randomly primed sublibra 4.6

441864 R34177 Hs.181315 ESTs, Moderately similar to ALU4 HUMAN ALU SU 4.6

445910 R93483 Hs.260273 ESTs 4.6

403531 predicted exon 4.6

429773 AI332482 Hs.218791 proteoglycan 4, (megakaryocyte stimulating factor, artic 4.6

422563 BE299342 Hs.19348 Homo sapiens cDNA FU13119 fis, clone NT2RP30026 4.6

422890 Z43784 Hs.78713 solute carrier family 25 (mitochondrial carrier; phospha 4.6

453663 AL048807 Hs.180714 cytochrome c oxidase subunit Via polypeptide 1 4.6

447839 N72050 Hs.164144 ESTs 4.5

415612 F12893 Hs.13301 ESTs 4.5

433371 T25451 gb:PTHI188 HTCDL1 Homo sapiens cDNA 5'/3' simila 4.5

410667 AW936099 gb:QVO-DT0020-210100-095-d04 DT0020 Homo sapie 4.5

410890 AW809575 gb:MR4-ST0121-060200-002-a12 ST0121 Homo sapie 4.5

404451 predicted exon 4.5

441705 AI087052 Hs.55993 ESTs 4.5

439597 W79579 Hs.58552 ESTs 4.5

407825 NM 006152 Hs.40202 lymphoid-restricted membrane protein 4.5

423073 BE252922 Hs.123119 MAD (mothers against decapentaplegic, Drosophila) ho 4.5

456278 BE300369 Hs.42643 ESTs, Weakly similar to KIAA1016 protein [H.sapiens 4.5

424719 H90452 gb:yv01c03.ri Soares fetal liver spleen 1 NFLS Homo sa 4.5

439542 AW297571 Hs.17646 ESTs 4.5

444433 AV649844 Hs.282436 ESTs 4.5

438831 BE263273 Hs.301128 ESTs 4.5

410065 AW812744 gb:RC3-ST0186-181099-012-c09 ST0186 Homo sapien 4.5

453895 AA039843 Hs.61948 ESTs 4.5

458250 AI807339 Hs.152174 ESTs, Weakly similar to Z140.HUMAN ZINC FINGE 4.5

423403 AA325483 gb:EST28475 Cerebellum II Homo sapiens cDNA 5' en 4.5

454679 AW813110 gb:CM4-ST0189-051099-021-f05 ST0189 Homo sapien 4.5

445368 AI221631 Hs.166788 ESTs 4.5

401004 predicted exon 4.5

425837 AF007567 Hs.159609 insulin receptor substrate 4 4.5

420497 AW206285 Hs.253548 ESTs 4.5

449438 AA927317 Hs.176719 ESTs 4.5

429409 AI694817 Hs.155980 ESTs 4.5

447959 AI452784 Hs.270270 ESTs 4.4

407340 AA810168 Hs.232119 ESTs 4.4

424326 NM 014479 Hs.145296 disintegrin protease 4.4

443479 AF027219 Hs.9443 zinc finger protein 202 4.4

443246 T75157 Hs.285516 ESTs, Weakly similar to hypothetical protein [H.sapien 4.4

414475 BE302955 Hs.119598 ribosomal protein L3 4.4

432075 AW972934 gb:EST385030 MAGE resequences, MAGM Homo sap 4.4

417906 R24769 Hs.23725 ESTs 4.4

406518 W28077 Hs.79389 nel (chicken)-like 2 4.4

441460 AI962478 Hs.226804 ESTs, Moderately similar to ALUC.HUMAN III! ALU 4.4

450549 T49427 Hs.181244 major histocompatibility complex, class I, A 4.4

426528 AA380828 gb:EST93827 Activated T-cells VII Homo sapiens cDN 4.4

430535 AW968485 gb:EST380561 MAGE resequences, MAGJ Homo sapi 4.4

408479 BE047329 Hs.144483 ESTs 4.3

448636 AI557139 Hs.129179 Homo sapiens cDNA FU13581 fis, clone PLACE10090 4.3

411280 N50617 gb:yy89h02.r1 Soares multiple sclerosis 2NbHMSP H 4.3

440790 AW593050 Hs.128580 ESTs 4.3

458301 AF003834 gb:AF003834 Clontech HI1148x Homo sapiens cDNA 4.3

442277 AW448914 Hs.202391 ESTs 4.3

449463 AI657038 Hs.196109 ESTs 4.3

433426 H69125 Hs.133525 ESTs 4.3

410782 AW504860 Hs.288836 Homo sapiens cDNA FU 12673 fis, clone NT2RM4002 4.3

423040 AA320749 Hs.209464 KIAA1604 protein 4.3

432430 AW079984 Hs.262480 ESTs 4.3

432072 N62937 Hs.269109 ESTs 4.3

452213 AL110237 Hs.28425 Homo sapiens mRNA; cDNA DKFZp566D224 (from c 4.3

403635 predicted exon 4.3

441919 AI553802 Hs.128121 ESTs 4.3

416717 H79559 Hs.297726 ESTs 4.3

430995 NM.005092 Hs.248197 tumor necrosis factor (ligand) superfamily, member 18 4.2

429269 AA449013 Hs.99203 ESTs 4.2

415840 R15955 Hs.21758 ESTs 4.2

451300 AA017066 Hs.237686 EST 4.2

445366 AI221511 Hs.298662 ESTs 4.2

424194 BE245833 Hs.169854 hypothetical protein SP192 4.2

459105 NM 014517 Hs.28423 upstream binding protein 1 (LBP-1a) 4.2

455387 BE069037 gb:QV3-BT0379-161299-040-e12 BT0379 Homo sapie 4.2

410507 AA355288 Hs.271408 ESTs 4.2

453823 AL137967 gb:DKFZp761D2315_r1 761 (synonym: hamy2) Homo 4.2

450966 AA017245 Hs.32794 ESTs 4.2

432694 AW991585 Hs.276755 ESTs, Weakly similar to F53B1.2 [C.elegans] 4.2

455108 AW856866 gb:RC0-CT0299-291199-031-G02 CT0299 Homo sapie 4.2

443609 AV650231 Hs.282941 ESTs 4.2 427469 AA403084 Hs 269347 ESTs 42

417178 N51636 gb yy87b01 s1 Soares_multιple_sclerosιs_2NbHMSP H 42

439751 AA196O90 Hs 50794 Homo sapiens mRNA full length insert cDNA clone EU 42

431982 AW419296 Hs 105754 ESTs 41

442641 AI890955 Hs 262983 ESTs 41

422128 AW881145 gb QV0-OT0033-010400-182-a07 OT0033 Homo sapie 41

449156 AF103907 Hs 171353 prostate cancer antigen 3 41

419668 AI033098 Hs 132777 ESTs 41

418236 AW994005 Hs 172572 hypothetical protein FU20093 41

432663 AI984317 Hs 122589 ESTs 41

448313 BE622486 Hs 121688 Homo sapiens cDNA FLJ13463 fis, clone PLACE10034 41

411279 AW884776 gb QV4-OT0067-010300-121-d01 OT0067 Homo sapie 41

440652 AI216751 Hs 143977 ESTs 41

416608 R11499 Hs 189716 ESTs 41

420405 AA743396 Hs 189023 ESTs 41

405717 predicted exon 41

435267 N23797 Hs 110114 ESTs 41

412228 AW503785 Hs 73792 complement component (3d/Epsteιn Barr virus) recepto 41

403560 AI929721 Hs 5120 dyπein, cytoplasmic, light polypeptide 41

449162 AI632740 Hs 10476 ESTs 41

459157 AI904385 gb CM-BT054-080399-054 BT054 Homo sapiens cDN 41

432474 AA584042 gb nn65e09 s1 NCI CGAP.Larl Homo sapiens cDNA 41

455388 AW936234 gb QVO-DT0020 090200-106-g05 DT0020 Homo sapie 40

426456 AA580748 Hs 130658 ESTs 40

438597 AA811662 Hs 171497 ESTs 40

437934 AW880871 Hs 77496 small nuclear πbonucleoprotein polypeptide G 40

459385 BE380047 gb 601159362F2 NIH.MGC.53 Homo sapiens cDNA 40

436404 AW968556 Hs 137240 Homo sapiens mRNA for partial 3'UTR, sequence 2 40

457740 AW500458 gb UI-HF-BNO akb-d 07-0-UI r1 NIH MGC 50 Homo 40

437385 AA757055 Hs 164060 ESTs 40

444530 AV650124 Hs 282435 ESTs 40

408066 AA046914 gb zf47h10 r1 Soares retina N2b4HR Homo sapiens cD 40

411256 AW834039 gb QV0-TT0010-091199-053 e09 TT0010 Homo sapie 40

433582 BE548749 Hs 148016 ESTs 40

438637 BE500941 Hs 126730 ESTs, Weakly similar to Kl AA1214 protein [H sapiens 40

414571 BE410746 Hs 22868 protein tyrosine phosphatase, non receptor type 11 40

446190 AI279299 Hs 256564 ESTs 40

443542 AI927065 Hs 146040 ESTs 40

430444 AW296421 Hs 121035 ESTs 40

454573 BE146471 gb QV0-HT0216-011199 043-c09 HT0216 Homo sapie 40

409846 AW501748 gb UI-HF-BROp-ajm b-12-O-UI r1 NIH.MGC.52 Horn 40

456141 AI751357 Hs 288741 Homo sapiens cDNA FLJ22256 fis, clone HRC02860 40

456140 AA169515 Hs 6006 ESTs 40

441685 AI459261 Hs 144481 ESTs 40

416677 T83470 gb yd46g06 r1 Soares fetal liver spleen 1 NFLS Homo s 40

401740 predicted exon 40

420122 AA255714 Hs 284153 Fanconi anemia, complementation group A 40

442594 AW272467 Hs 254655 Uπtitled 39

426294 AA374185 gb EST86289 HSC172 cells 1 Homo sapiens cDNA 5' e 39

411922 AW876260 gb PM4-PT0019-131299-006-EO4 PT0019 Homo sapie 39

452320 AA042873 Hs 160412 ESTs 39

431644 AW972822 Hs 169248 cytochrome c 39

409892 AW956113 gb EST368183 MAGE resequences, MAGD Homo sap 39

418132 T92670 Hs 117421 ESTs 39

414372 AA143654 gb zo65a02 r1 Stratagene pancreas (937208) Homo sap 39

400196 predicted exon 39

416900 M59964 Hs 1048 KIT ligand 39

445444 AA380876 Hs 270 plecksfrin homology, Sec7 and coiled/coil domains, bind 39

435957 N39015 Hs 190368 ESTs 39

442299 AW467791 Hs 155561 ESTs 39

419499 AA808136 Hs 177698 ESTs 39

438403 AA806607 Hs 292206 ESTs 39

449386 AA001308 Hs 193213 ESTs 39

443283 BE568610 gb 601342622F1 NIH.MGC.53 Homo sapiens cDNA 39

406481 predicted exon 39

453530 AW021633 gb df26c02 y1 Morton Fetal Cochlea Homo sapiens cDN 39

415558 AA885143 Hs 125719 ESTs 39

416874 H98752 Hs 42568 ESTs 39

454885 AW836922 gb QV1 -LT0036-150200-074-h06 LT0036 Homo sapie 39

419896 Z99362 gb HSZ99362 DKFZphamyl Homo sapiens cDNA clon 39

440962 AI989961 Hs 233477 ESTs, Moderately similar to A Cham A, Secypa Compl 39

419401 AW804663 gb QV4-U 0094-160300-135-d06 UM0094 Homo sap 39

406562 predicted exon 38

405690 BE409855 Hs 808 heterogeneous nuclear πbonucleoprotein F 38

435282 AA677428 Hs 189731 ESTs 38

402451 predicted exon 38

451577 N69101 Hs 32703 ESTs 38

457141 AA521410 Hs 41371 ESTs 38

407817 H92553 Hs 40400 ESTs 38

412613 AA653507 Hs 285711 Homo sapiens cDNA FU13089 fis, clone NT2RP30021 38

418355 L42563 Hs 1165 ATPase, H+/K+ transporting, nongastπc, alpha polypep 38

446357 AW161533 Hs 300866 ESTs 38

407448 AJ001865 gb Homo Sapiens mRNA, partial cDNA sequence for h 38

456383 AI148037 gb qg61e01 r1 Soares.testis.NHT Homo sapiens cDNA 38 444651 W58469 Hs 103120 ESTs 38

455067 AW854538 gb RC3-CT0255-200100-024-b02 CT0255 Homo sapie 38

442657 BE502631 Hs 130645 ESTs 38

429142 AA835639 Hs 104972 ESTs 38

429274 AI379772 Hs 99206 ESTs 38

437774 AW978199 Hs 291648 ESTs 38

427737 AA435988 Hs 178066 ESTs, Weakly similar to AF0682895 HDCME31 P [H s 38

405671 predicted exon 38

413627 BE182082 Hs 246973 ESTs 38

438858 R37529 Hs 269924 ESTs 38

416612 H70565 gb yr97c04 r1 Soares fetal liver spleen 1 NFLS Homo sa 38

423045 AW967472 Hs 301511 ESTs, Highly similar to KPT2 HUMAN SERINE/THR 38

453361 AA035197 Hs 107375 ESTs 37

437243 AA747549 Hs 259122 ESTs 37

437987 AW450202 Hs 122963 ESTs 37

408781 BE148621 Hs 254602 ESTs 37

455895 BE154837 gb PM1-HT0345-121199-001-C08 HT0345 Homo sapie 37

431492 AW612343 gb hg97c10 x1 NCI.CGAP.Kid11 Homo sapiens cDN 37

413247 AW963969 gb EST376042 MAGE resequences, MAGH Homo sap 37

422866 NM 002410 Hs 121502 annosyl (alpha-1,6-) glycoprotein beta-1,6-N acetyl-jj 37

431828 AA572994 gb nm33f12 s1 NCI.CGAP ϋp2 Homo sapiens cDNA 37

438872 R64197 Hs 23589 ESTs 37

438673 AI824717 Hs 123443 ESTs 37

416624 H69044 gb yr77h05 s1 Soares fetal liver spleen 1 NFLS Homo sa 37

401963 predicted exon 37

402867 predicted exon 37

408315 AW179148 gb MR4-ST0067-200899-002-B07 ST0067 Homo sapie 37

418320 D86981 Hs 84084 amyloid beta precursor protein (cytoplasmic taιl)-bιndιn 37

447199 AI939421 Hs 160900 ESTs 37

422590 AA312758 Hs 193945 Homo sapiens cDNA FLJ13962 fis, clone Y79AA10012 37

451996 AW514021 Hs 245510 ESTs 37

412463 AW953444 Hs 78672 laminin, alpha 4 37

440928 AL046575 Hs 130198 ESTs 37

441951 W31002 Hs 128195 ESTs 37

440705 AA904244 Hs 153205 ESTs 37

434231 AF119901 Hs 250568 hypothetical protein PR02831 37

411039 AL135674 Hs 163348 ESTs 37

413137 BE066915 gb PMO BT0340-231199 001-b07 BT0340 Homo sapie 37

417970 AA309234 Hs 57760 Homo sapiens cDNA FLJ23119 fis, clone LNG07978 37

439786 AV652707 Hs 33756 Homo sapiens mRNA full length insert cDNA clone EU 37

459595 AL040421 gb DKFZp434B0714 M 434 (synonym htes3) Homo s 37

443601 AI078554 Hs 15682 ESTs 37

404041 predicted exon 36

406122 predicted exon 36

404582 predicted exon 36

455786 BE090077 gb RC6-BT0710-300300-021 -F02 BT0710 Homo sapie 36

411899 AA370573 gb EST82238 Prostate gland I Homo sapiens cDNA 5' e 36

426758 AL036430 Hs 197772 ESTs 36

421776 AW301994 Hs 108183 candidate tumor suppressor p33 ING1 homolog 36

430169 AA468531 Hs 189047 ESTs 36

407695 A1808007 Hs 66450 ESTs 36

454564 AW807573 gb MR1-ST0088 021299-004-g01 ST0088 Homo sapie 36

425902 X52509 Hs 161640 tyrosine ammotransferase 36

439328 W07411 Hs 118212 ESTs, Moderately similar to ALU3 HUMAN ALU SU 36

429066 AA868555 Hs 178222 ESTs 36

428690 AI948490 Hs 98765 ESTs 36

437302 AA837146 Hs 180275 ESTs 36

443973 AI580083 Hs 176154 ESTs 36

453993 AW615224 Hs 252839 ESTs 36

413623 AA825721 Hs 246973 ESTs 36

409196 NM.001874 Hs 169765 carboxypeptidase M 36

424916 AW867440 Hs 23096 ESTs 36

424769 H06469 Hs 142653 ret finger protein 36

400080 predicted exon 36

421521 AI638760 Hs 161795 ESTs 36

405549 predicted exon 36

446114 AI275715 Hs 145926 ESTs 36

441392 AW451831 Hs 222119 ESTs, Weakly similar to K1CQ.HUMAN KERATIN, T 36

424025 AI701852 Hs 301296 ESTs 35

448527 AI525606 gb PT1 3.03.G05 r tumo Homo sapiens cDNA 5', mR 35

437063 AA351109 Hs 5437 Taxi (human T-cell leukemia virus type I) binding prat 35

449880 AI673006 Hs 231948 ESTs, Weakly similar to ALUB.HUMAN «" ALU CL 35

449311 AI657014 gb tt49a12x1 CI CGAP GC6 Homo sapiens cDNAc 35

442999 AW662889 Hs 132395 ESTs 35

416238 W90448 gb zh78c08 s1 Soares Jetal_lιver_spleen_1NFLS_S1 H 35

423209 BE278528 Hs 106823 H sapiens gene from PAC 426I6, similar to syntaxm 7 35

409854 AW501833 gb UI-HF-BR0p-ajo-d-01-0-UI r1 NIH MGC 52 Horn 35

414941 C14865 Hs 182159 ESTs 35

456337 AW751661 Hs 65919 ESTs 35

415296 F05086 gb HSC01 A011 normalized infant brain cDNA Homo s 35

423338 AB007961 Hs 127338 KIAA0492 protein 35

415618 F12954 gb HSC3GG091 normalized infant brain cDNA Homo s 35

405583 predicted exon 35

435601 AF217509 Hs 283077 cenfrosomal P4 1-assocιated protein, uncharacteπzed bo 35 450867 AA011454 Hs 245122 ESTs 35

431339 AA506294 Hs 257266 ESTs 35

441969 AI733386 Hs 129194 ESTs, Weakly similar to ALU1 HUMAN ALU SUBFA 35

431343 AW970603 Hs 300941 Homo sapiens cDNA FU1166Ϊ fis, clone HEMBA100 35

434317 AI674095 Hs 116323 ESTs 35

414741 R51321 Hs 25780 Homo sapiens cDNA FU12252 fis, clone MAMMA10 35

439707 AW297702 Hs 102915 ESTs 35

443178 AI631241 Hs 47312 ESTs 35

400397 AJ270770 Hs 154485 franscπptioπ factor 7-Iιke 2 (T-cell specific, HMG box) 35

455887 BE154173 gb PM1-HT0340-201299-004-f12 HT0340 Homo sapie 35

434362 W27081 Hs 295446 ESTs 35

409211 AA078835 gb zm94h04 s1 Stratagene colon HT29 (937221) Homo 35

414390 BE281040 gb 601156234F1 NIH MGC 21 Homo sapiens cDNA 35

457142 AI924353 Hs 290969 EST 35

423006 U29700 Hs 123014 anti-Mulleπan hormone receptor, type II 35

453363 AI989776 Hs 232623 ESTs 35

418913 BE046745 gb hn39b06 x1 CI CGAP RDF2 Homo sapiens cDN 34

440016 AW118114 Hs 137057 ESTs 34

405096 predicted exon 34

435072 AW592176 Hs 116932 ESTs 34

438535 L09078 gb Homo sapiens mRNA fragment 34

424001 W67883 Hs 137476 KIAA1051 protein 34

428361 NM 015905 Hs 183858 transcriptional intermediary factor 1 34

410587 AA370706 Hs 11252 ESTs, Weakly similar to Weak similarity with the Ysy6 34

454543 AW806895 gb QV4-ST0023-160400-172-C06 ST0023 Homo sapien 34

419515 S81944 Hs 90791 gamma-aminobutync acid (GABA) A receptor, alpha 6 34

410280 AA083558 Hs 261286 ESTs 34

425714 AW963278 gb EST375351 MAGE resequences, MAGH Homo sap 34

416895 AW961600 gb EST373672 MAGE resequences, MAGG Homo sap 34

427935 AW503687 Hs 119424 ESTs, Weakly similar to unnamed protein product [H sa 34

411673 BE064863 gb RC1-BT0313-110300-015-f06 BT0313 Homo sapien 34

453339 AW992599 Hs 252797 ESTs 34

424696 BE439547 Hs 151903 Homo sapiens clone 24706 mRNA sequence 34

436242 AK002187 gb Homo sapiens cDNA FLJ11325 fis, clone PLACE10 34

442837 AI022082 Hs 50492 ESTs 34

452807 AA028933 Hs 162434 ESTs 34

418110 R43523 Hs 217754 Homo sapiens cDNA FU22202 fis, clone HRC01333 34

433936 AI208072 Hs 123459 ESTs 34

458177 AI744995 Hs 267072 ESTs, Moderately similar to ALU4 HUMAN ALU SU 34

401896 predicted exon 34

406237 predicted exon 34

457688 AL110157 Hs 3843 Homo sapiens mRNA, cDNA DKFZp586F2224 (from 34

456914 AW363582 Hs 75323 prohibitin 34

421916 R34441 Hs 101007 Homo sapiens cDNA FU23546 fis, clone LNG08361 34

419321 N48146 Hs 269069 ESTs 34

447876 AV654978 Hs 19904 cystathionase (cystathionine gamma-lyase) 34

406197 predicted exon 34

443005 AI027184 Hs 200918 ESTs 34

450078 A1681743 gb tx38g10 x1 NCI CGAP Lu24 Homo sapiens cDNA 34

431301 AA502384 Hs 151529 ESTs 34

430202 T85775 gb yd60g02 r1 Soares fetal liver spleen 1 NFLS Homo s 34

428559 H24338 Hs 27041 ESTs 34

455731 BE072188 gb QV4-BT0536-211299 055 b09 BT0536 Homo sapie 34

420735 AW297440 Hs 88653 ESTs 34

430881 NM.000809 Hs 248112 gamma aminobutyπc acid (GABA) A receptor, alpha 4 33

405836 predicted exon 33

449178 AI633748 Hs 197597 ESTs 33

453265 U61232 Hs 32675 tubu n-specific chaperone e 33

430700 AA768902 Hs 247812 H2A histone family, member K, pseudogene 33

424496 AI733451 Hs 129212 ESTs 33

446963 AI862668 Hs 176333 ESTs 33

422879 AI241409 Hs 188092 ESTs 33

419831 AW448930 Hs 5415 ESTs 33

449570 AA001793 gb zh86c06 r1 Soares_fetal_lιver_sρleen_1NFLS_S1 H 33

406255 predicted exon 33

41231a AW936903 gb RC1-DT0029-030200-012-d02 DT0029 Homo sapie 33

401350 predicted exon 33

439098 AF085955 gb Homo sapiens full length insert cDNA clone YR86G 33

450589 AI701505 Hs 202526 ESTs 33

430749 AJ242956 Hs 25960 v-myc avian myelocytomatosis viral related oncogene, n 33

430689 AI695595 Hs 293219 ESTs 33

454753 AW819212 gb CM1-ST0283-071299-061-C07 ST0283 Homo sapie 33

444479 AA194980 Hs 30818 Homo sapiens cDNA FU13681 fis, clone PLACE20000 33

413516 BE145907 gb MR0-HT0208-221299-204-e12 HT0208 Homo sapie 33

425541 AA359119 gb EST68172 Fetal lung II Homo sapiens cDNA 5' end, 33

457107 AA418246 Hs 185796 ESTs, Weakly similar to b34!8 1 [H sapiens] 33

421480 NM.016158 Hs 104671 erythrocyte transmembrane protein 33

444289 BE267060 Hs 76391 myxovirus (influenza) resistance 1, homolog of muπne 33

417725 R25257 Hs 21503 ESTs 33

453631 AL046418 gb DKFZp434N247_r1 434 (synonym htes3) Homo sa 33

450692 H50603 Hs 94037 hypothetical protein FU23053 33

413357 W47611 gb zc35e06 r1 Soares_seπescent_fibroblasts_NbHSF H 33

415327 H22769 Hs 1861 membrane protein, palmitoylated 1 (55kD) 33

457569 AW970021 Hs 291120 ESTs, Weakly similar to ALU8.HUMAN ALU SUBFA • 33 448601 R61666 Hs 293690 ESTs 33

436526 AW993633 Hs 287681 Homo sapiens cDNA FU21685 fis, clone COL09372 33

440589 BE397763 Hs 194478 Homo sapiens mRNA, cDNA DKFZp43401572 (from 33

418768 T39310 Hs 1139 cold shock domain protein A 33

426768 AW303337 Hs 270411 ESTs 33

400394 AF040257 Hs 283818 Homo sapiens TNF receptor homolog mRNA, partial cd 33

433565 AA599763 Hs 112520 ESTs 33

424093 AA335025 gb EST39621 Epididymus Homo sapiens cDNA 5' end, 33

449552 AA001742 Hs 83722 ESTs 33

431892 AA521315 Hs 194424 ESTs 33

405512 predicted exon 33

446990 AI354717 Hs 223908 ESTs 33

457729 AI821863 Hs 293467 ESTs, Weakly similar to ALU7.HUMAN ALU SUBFA 32

417333 AL157545 Hs 42179 bromodomain and PHD finger containing 3 32

456420 AW401361 Hs 91773 protein phosphatase 2 (formerly 2A), catalytic subunit, 32

403497 predicted exon 32

427145 R52635 Hs 25935 ESTs 32

406454 predicted exon 32

441033 BE562555 gb 601335867F1 NIH MGC 44 Homo sapiens cDNA 32

408444 AW661839 Hs 253204 ESTs 32

434739 AA804487 Hs 144130 ESTs 32

437060 AA745591 Hs 292063 ESTs 32

423092 BE274837 Hs 123637 putative homeodomain traπscπption factor 32

424695 U58331 Hs 151899 sarcoglycan delta (35kD dystrophin associated glycopr 32

443362 AI053464 Hs 166505 ESTs 32

437500 AL390150 gb Homo sapiens mRNA, cDNA DKFZp547L156 (from 32

425458 H89317 Hs 182889 ESTs 32

439171 AA831133 Hs 294128 ESTs 32

407647 AW860158 gb RCO CT0379-290100-032 b04 CT0379 Homo sapie 32

435608 AW183971 Hs 250896 ESTs 32

426743 AA383833 Hs 245022 ESTs 32

457525 AW973800 gb EST385901 MAGE resequences MAGM Homo sap 32

413800 AI129238 Hs 192235 ESTs 32

414193 BE260069 gb 601150964F1 NIH MGC 19 Homo sapiens cDN A 32

455565 BE000537 gb RC3 BN0072-240200 011 d07 BN0072 Homo sapie 32

410061 T91029 Hs 15069 ESTs 32

450666 T99968 Hs 18799 ESTs 32

458529 AV652120 Hs 213232 ESTs 32

424751 AA769482 Hs 296320 ESTs 32

442225 AI306597 Hs 129192 ESTs 32

410990 AW812929 gb RC3-ST0186-250200 018-C05 ST0186 Homo sapien 32

435644 AA700867 Hs 269659 ESTs 32

405347 predicted exon 32

441202 AI632143 Hs 135853 ESTs 32

446694 AV659942 Hs 258132 ESTs 32

454652 AW812088 gb RC4-ST0173-191099 032-a07 ST0173 Homo sapien 32

418985 AI042330 Hs 87128 ESTs, Weakly similar to similar to YBS4 YEAST [C el 32

430118 AI377255 Hs 183287 ESTs 32

430691 C14187 Hs 103538 ESTs 32

416313 H47206 Hs 194109 ESTs, Weakly similar to ALUB HUMAN mi ALU CL 32

446122 AI362790 Hs 181801 ESTs 32

453725 W28543 gb 48c5 Human retina cDNA randomly pπmed sublibra 32

453954 AW118336 Hs 75251 DEAD/H (Asp-Glu Ala Asp/His) box binding protein 1 32

428166 AA423849 Hs 79530 M5-14 protein 32

447506 R78778 Hs 29808 Homo sapiens cDNA FU21122 fis, clone CAS05917 32

401871 predicted exon 32

442160 AI337127 Hs 156325 ESTs 32

404708 predicted exon 3 1

412588 AW993055 Hs 44024 ESTs 31

431976 AA719001 Hs 291065 ESTs 31

408884 AW891024 Hs 281172 ESTs 31

433811 AW975015 Hs 123138 ESTs 3 1

431691 AI208511 Hs 292510 ESTs 31

418719 AW975590 Hs 161707 ESTs 3 1

431740 N75450 Hs 183412 ESTs, Moderately similar to AF116721 67 PR01777 [H 31

435699 AI911488 Hs 213724 ESTs 31

459344 AW499533 Hs 257976 ESTs 31

431729 AW004714 Hs 162033 ESTs 3 1

436771 AW975687 Hs 292979 ESTs 31

434480 AW956268 Hs 59395 Homo sapiens clone IMAGE 112574 mRNA sequence 31

459547 AI400579 Hs 225186 EST 31

427962 AA946582 Hs 133546 Homo sapiens cDNA FU21120 fis, clone CAS05691 31

403743 predicted exon 31

413560 BE148411 gb MR0-HT0241-131299 002-W4 HT0241 Homo sapie 31

454372 H96643 Hs 283565 FOS like antιgeπ-1 31

450018 AA421642 Hs 24309 hypothetical protein FU 11106 31

428839 AI767756 Hs 82302 ESTs 31

407110 AA018042 Hs 95078 ESTs 31

436133 T77531 Hs 191124 ESTs 31

418872 R94785 Hs 270263 ESTs 3 1

404418 predicted exon 31

446877 AI559472 Hs 270720 ESTs 31

429053 AA443967 Hs 194114 ESTs 31

425189 H16622 gb ym26c07 r1 Soares infant brain 1 NIB Homo sapiens 31 404134 predicted exon 3.1

441404 AI638880 Hs.126895 ESTs 3.1

400076 predicted exon 3.1

411876 AW961336 Hs.69705 ESTs, Weakly similar to KIAA0443 [H.sapiens] 3.1

451048 AA013349 Hs.60602 ESTs 3.1

447021 AI356564 Hs.161406 ESTs 3.1

404083 predicted exon 3.0

415833 H05175 Hs.107510 ESTs 3.0

402142 predicted exon 3.0

415820 R53720 Hs.189745 ESTs 3.0

441140 AW016534 Hs.226994 ESTs 3.0

449376 AA001278 Hs.59905 ESTs 3.0

457593 AI738815 Hs.117323 ESTs 3.0

411542 AW850767 gb:IL3-CT0220-031199-025-A05 CT0220 Homo sapien 3.0

403375 predicted exon 3.0

449561 AI022240 Hs.17924 ESTs 3.0

406241 predicted exon 3.0

420306 AA258318 Hs.219226 ESTs 3.0

413161 BE068130 gb:CM2-BT0368-171299-056-a01 BT0368 Homo sapie 3.0

448221 BE622615 gb:601440775T1 NIH.MGC.72 Homo sapiens cDNA 3.0

415920 Z45684 gb:HSCZRD121 normalized infant brain cDNA Homo 3.0

459135 AI902802 gb:RC-BT015-311298-026 BT015 Homo sapiens cDNA 3.0

425357 AA355842 gb:EST64303 Jurkat T-cells VI Homo sapiens cDNA 5' 3.0

454724 AA091228 gb:cchn2152.seq.F Human fetal heart, Lambda ZAP Ex 3.0

429395 AK002071 Hs.201624 hypotheticaLprotein FLJ11209 3.0

427607 AA406119 Hs.270479 ESTs 3.0

443598 AW499970 Hs.14822 ESTs 3.0

437948 AA772920 gb:ae73c09.s1 Stratagene schizo brain S11 Homo sapien 3.0

418105 AW937488 Hs.178000 ESTs 3.0

426763 AL042262 Hs.172101 Human DNA sequence from clone RP1-202I21 on chro 3.0

403473 predicted exon 3.0

427501 A1369280 Hs.131743 ESTs 3.0

453246 NM.000933 Hs.32539 KIAA1264 protein 3.0

404587 M99587 Hs.104134 homeo box (H6 family) 1 3.0

433964 AW241987 Hs.197025 ESTs 3.0

453472 AL037925 gb:DKFZp564M037_r1 564 (synonym: hfbr2) Homo sa 3.0

433183 AF231338 Hs.222024 transcription factor BMAL2 3.0

435899 W89093 Hs.189914 ESTs 3.0

425626 AI537536 Hs.173519 ESTs 3.0

428931 AA994979 Hs.98967 ATPase, H(+)-fraπsporting, lysosomal, noncatalytic ace 3.0

426593 AW958560 gb:EST370630 MAGE resequences, MAGE Homo sapi 3.0

431899 AA521381 Hs.187726 ESTs 3.0

422406 AF025441 Hs.116206 Opa-interacting protein 5 3.0

448178 AI479482 Hs.170789 ESTs 3.0

404227 predicted exon 3.0

440575 AA889870 Hs.126006 ESTs 3.0

431198 AL047634 Hs.231913 ESTs 3.0

434221 AF119885 Hs.283040 hypothetical protein PR02543 3.0

459459 AA460445 gb:zx66h11.r1 Soares_total_fetus_Nb2HF8_9w Homo 3.0

TABLE 5B:

Pkey: Unique Eos probeset identifier number CAT number Gene cluster number Accession: Genbank accession numbers

Pkey CAT Number

407596 1003489 1 R86913 R86901 H25352 R01370 H43764 AW044451 W21298

407647 1007366 1 AW860158 AW862385 AW860159 AW862386 AW862341 AW821869 AW821893 AW062660 AW062656

408066 103649 1 AA046914AA057231 H38371

408315 1051132.1 AW179148AW179150

409211 110906 1 AA078835 AA079319 AA078816 AA079026 AA122167 AA111933 AA068989 AA084691 AA068999 AA069038 AA069225 AA650522

409699 '1149033 1 BE154650 BE154785 AW468343 BE154816 BE154667

409846 1156150 1 AW501748AW502972AW502513

409854 1156229 1 AW501833 AW502145 AW502581

409892 1157859 1 AW956113AW503580

410065 1174258 1 AW812744 AW581974 AW812725

410454 1204154 1 AW749041 BE066025 H85202

410495 1205826 1 N95428 W24040 AW751366 H81987

410596 121053 1 AA374186 AW963684 AA086107 AI491986

410667 1214679 1 AW936099 AW936243 AW936097 BE162104 BE162109 AW794263

410758 1219899 1 BE535988 AW801777

410890 1226008 1 AW809575 BE090626 BE090617 AW936551 AW936552 AW936530 AW936550 AW936481

410990 1228649 1 AW812929 AW812779 AW813088

411256 1236790 1 AW834039 AW834040 AW834047 AW845410 BE003128 AW852479

411279 1237516 1 AW884776 AW935737 AW835261 AW835247 AW835246 AW835263 AW835240 AW835258

411280 1237585 1 N50617 N47321 R54159 AW860545 AW835317

411337 1239217.1 AW837349 AW837355 AW882717

411542 1249095 1 AW850767 AW851180 AW851359 AW851223 AW851360 AW851222 AW851108

411543 1249127 1 AW851248 AW851425 AW850805 AW851021 AW850905

411673 1253737.1 BE064863 BE153698 AW856751 BE153820 BE064737 BE153674 BE064730 BEOS5062 BE153536 A 856622 BE155079 BE064651

BE153665 BE064650 BE064691

411899 126497 1 AA370573 BE160501 BE160500 BE160498 BE160502 BE160497 N72424 AA096462

411922 1265825 1 AW876260 AW876269 AW876340 AW876146 AW876323 AW876320 AW876171 AW876421 AW876227 AW876243

412319 1288602 1 AW936903 AW936907 AW936908 AW936914 412480 1299291 BE142364 BE142341 AA112025

412732 13239511 AW993300 N23107 R22345

413137 13503831 BE066915 BE066942

413161 1351262.1 BE068130 BE068135 BE068134 BE068183 BE068184 BE068094

413247 1355441 AW963969 AW963971 AA127651 AA376726

413357 13641651 W47611 BE087851

413516 13745951 BE145907 BE145796 BE145803 BE145851 BE145923 BE145812 BE145809 BE145852 BE145856

413560 13766211 BE148411 BE148415 H59098

414193 1424706.-2 BE260069

414337 14367061 BE386606 BE275195 BE274984

414372 143909.1 AA143654 AW753140 AA213770 AW970865 AA569075 AA492132

414390 1441570 -1 BE281040

415296 15335281 F05086 F05091 R17158

415618 15406511 F12954 H10624 R11948 R56523T75190

415920 15617331 Z45684 H09361 53285

416211 15789931 R14625 R17952 H29120 R14650

416238 15804511 W90448 H30749

416612 16038851 H70565 N77403 H67949

416624 16046941 H69044T47567 H75691 T50292

416677 16086211 T83470 T84283 H74054

416895 1628741 AW961600 AA190217 AA321260

417178 16555651 N51636 T51874 T51829

417762 1697501 AA205976 AA205930

418913 1805201 BE046745 AI074878 AI817476 AW572513 AA447586 H28330 AA232486 AA365704 BE271167

419401 1844541 AW804663 AW805017 AA236969

419896 1888662.1 Z99362 Z99363

420352 1929791 BE258835 AW968316 AA258918 AW843305 R14744 AI580388 BE071923 R36280

421418 2022881 AA806639 AA291008 AA836274 AW978806

422046 2107441 A1638562 T16929 H13401 F07773 R55836

422128 2119941 AW881145 AA490718 M85637 AA304575 T06067 AA331991

423403 2279421 AA325483 AW962169 AW962660

424093 2352331 AA335025 AA335496 AW966145

424719 2428891 H90452 AA345767 AW964302 H90399

425189 247825.1 H16622 R17322 AA351959

425357 250578 -1 AA355842

425541 252945.1 AA359119 A 963014 D79884

425714 2553331 AW963278 AA362266 AA362267

426294 263994.1 AA374185 AW956180 H38344

426528 268722.1 AA380828 AW963760 AA380805 AA380830

426593 2697481 AW958560 AA382199 AW444933

430202 3143221 T85775 AW968345 AA468998

430535 3196431 AW968485 AW968670 AA480922 BE350425

431075 3276381 BE267477 AA491488 AW836723

431492 3339301 AW612343 AA922558 AA505925 AA927038 AW972537 AI693564

431828 3382011 AA572994 AA516249 AA702595

432075 3410661 AW972934AA525260 AA525266 AA835021 BE000149 BE000148

432474 3481971 AA584042 AW973273 AA548798

433371 3644301 T25451 AA585296AA585305

433403 36534 -1 AF040247

433767 3740141 AA609245 AA724581 AW241989 A1377274 47300

434738 392562.1 AA836265 AA648266 AW974440

436196 415621 AK001084 AA078092 AA829049

436242 416411 AK002187 R66351

436812 4273231 AW298067AA731645AA810101 AW194180AI690673AW978773

437500 43772.1 AL390150 AW959182 AA358923

437948 4459661 AA772920 D59870 D61151 AI591331

438224 4526561 AA933999 AA781181

438535 459461 L09078 L03145 L09094 L09098 L03165 L09102

439098 468591 AF085955 H69158 H69081

439126 46887.1 AF085984 H95905 H95906

441033 50807 -1 BE562555

443283 56492.-1 BE568610

445597 6445131 H65649AW753545AI244270

445832 6519251 AI261545 N59134 AW875371 AW875247

448221 75534 -1 BE622615

448527 7667071 AI525606 BE549857

448732 77773 -1 BE614063

449311 8045131 AI657014 AW594035 AI657036 AI638390

449570 810181 AA001793 AA001871

450078 823882.1 AI681743 AW897287 AW897205 AW897284

452351 912331 AA025647 R45716 AW753786

452453 9183001 AI902519AI902518AI902516

453472 9683711 AL037925 AL037931 AL037957

453530 970211 AW021633 AA036730 AI866854

453631 9750241 AL046418 N52738 R33840

453725 9787601 W28543AL119531

453752 9798991 AL120800 BE378580

453823 9825261 A 137967 BE064160 BE064186

454102 10116031 AW752363 BE147120 N22640

454487 1216101J AW796342 AW796356 BE161430

454543 12237751 AW806895 AW866476 AW866465 AW866535 AW866623

454564 12244071 AW807573 AW807566 AW807572

454573 12256241 BE146471 AW833743 AW833609 AW821469 AW821488 AW821541 AW821531 AW821513 AW821549 AW821384 AW821625 AW821577

AW821547AW834577 454652 1228071 1 AW812088 AW812105 AW812082

454679 12289291 AW813110 AW813113

454724 1231281 AA091228 H71860 H71073

454753 1233576.1 AW819212AW819170 BE158474AW819172AW819213AW819200AW819256AW819254AW819178AW819214AW819215AW819233

AW819171

454885 12388741 AW836922 AW876719 AW876688 AW836919 AW836997 AW836908 AW836912 AW836993

454940 1245640.1 AW846202 AW846174 AW846532 AW846181 AW846458 AW846206 AW846432 AW846553 AW846533 AW846197 AW846198 AW846189

AW846469 AW846530 AW846560 AW846536 AW846472 AW846470 AW846466 AW846192 AW846479 AW846260 AW846204 AW846139

AW846187 AW846353 AW846462 AW846151 AW846549 AW846538 AW846527 AW846567 AW846531

454994 1248637.1 AW850176 AW850513AW850412AW850451

455056 12509341 AW853057 AW853039 AW853042 AW853050 AW853114 AW853105 AW853102 AW853111 AW853121 AW853109 AW853126

455067 12520501 AW854538 AW854418 AW854412

455108 12539161 AW856866 AW856858 AW856856

455387 1287871.1 BE069037 AW936025 BE069178 AW936034

455388 1287904J AW936234AW936074AW936181 AW936179 AW936217AW936077 AW936227 AW936191

455534 13229421 AW991925 AW991919

455565 1329591 1 BE000537 BE180584 BE180540 BE180542 BE180546

455731 1353872.1 BE072188 BE072299 BE072269 BE072317 BE072238

455786 13655101 BE090077 BE090079

455790 13659501 BE090690 BE090688 BE090681 BE090693 BE090675

455887 13808361 BE154173 BE154098 BE154096

455895 13813861 BE154837 BE154879 BE154850 BE154877 BE154835 BE154849 BE154902 BE154905 BE154867 BE154901 BE154904 BE154899

456253 16991781 T12198 T19684T11583 R15526 R15585 R45876 R15562

456383 184252.1 AI148037 AA287178 AA236756

456388 1842839 -1 W28557

457525 351732.1 AW973800 AA557589 AA559886

457740 395281 AW500458 AW160900 AF161362 AF150327 AW578393 AW360921 AW360920 AW360902 AW360890 AW732529

458301 5430581 AF003834W36292

459135 9185161 AI902802 AI902783 AI902800

459157 9198042 A1904385 A1904382

TABLE SC

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham I etal " refers to the publication entitled The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489 495

Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons

Pkey Ref Strand NLposition

400942 7656749 Minus 91593-91757,9272092843,93962-94079,94824-94997

401004 7229982 Plus 62580-62772

401287 9801612 Minus 42287-42431

401308 9212516 Plus 169019-169649

401350 9931226 Plus 14471-14623

401740 2982169 Pius 148357-148484,148591-148690

401871 8079355 Minus 58158-59585

401896 8569194 Plus 115129-115294

401963 3126783 Plus 51382-51521

402105 8131588 Minus 22856-24055

402109 8131678 Minus 171722-171859,173197-173303

402142 7704985 Minus 29932-30698

402451 9796677 Minus 48137-48343

402867 5596716 Plus 52806-53106,53500-53818

403277 8072597 Minus 27494-27642

403283 8076905 Minus 71124-71996

403375 9255944 Minus 92554-92795

403473 9945095 Minus 54241-54437

403497 6067111 Plus 7221-7441

403531 8076842 Minus 75903-76134

403635 6862664 Minus 157028-157145,161725-161900

403714 7210030 Minus 145556-145873

403743 7652003 Minus 136463-136646

404020 8655966 Minus 174449-174663

404041 8886967 Minus 1334-1503,2483-2585,5230-5337,19656-19804

404044 9558573 Minus 225757-225939

404083 9944029 Minus 16650-17082

404108 8247074 Minus 63603-64942

404134 6981900 Minus 40633-40911

404227 7838233 Minus 93110-93259

404418 7382420 Minus 153339-153481,155099-155294

404451 7638438 Minus 105191-105622

404582 9739220 Plus 53230-53424

404708 9800828 Plus 77522-77658

404868 9454593 Plus 39954-40430

405096 8072599 Plus 140844-140897,148510-148581

405290 3900849 Minus 79582-79765

405347 2979602 Minus 977-1116

405512 9454624 Plus 17802-17966,18573-18697

405549 1552494 Plus 10878-11048

405583 4512287 Plus 56211-56353

405671 2565031 Plus 25805-26923

405717 9588573 Plus 11275-11973

405752 9212305 Plus 91392-91528

405836 5686282 Minus 5031-5217 406122 9144087 Minus 30940-31386

406197 7289992 Minus 4752047961

406237 7417725 Plus 30032-30501

406241 7417725 Minus 34951-35752

406255 7417729 Plus 2959-3200

406364 9256114 Minus 50715-50833

406454 9588380 Minus 91746-91958

406481 9864741 Minus 91439-91579

406562 7711584 Plus 37316-37426

406605 8272666 Minus 23275-23493,23723-23903

TABLE 6A lists about 68 genes highly down-regulated in ovanan cancer compared to normal ovanes These were selected as for Table 5A, except the "average" ovarian cancer level was set to the maximum value amongst various ovanan cancers and the "average" normal ovary level was set to the minimum value from vaπous non malignant ovary specimens, and the ratio was greater than or equal to 25 (ι e 25-fold down regulated in the highest tumor vs the lowest normal ovary) This has the overall effect of increasing stπngency, and reducing the number of false-positives

TABLE 6A ABOUT 68 HIGHLY DOWN-REGULATED GENES, OVARIAN CANCER VERSUS NORMAL OVARY

Pkey Pπmekey

Ex Accn Exemplar Accession

UG ID UniGenelD

Title UniGene Title ratio ration of normal ovary vs tumor

Pkey Ex Accn UG ID Title ratio

424851 AA676441 Hs 119059 ESTs 79

437690 AA804362 Hs 180544 ESTs 47

433682 AA642418 Hs 17381 ESTs 41

407437 AF220264 gb Homo sapiens MOST-1 mRNA, complete eds 4 1

437787 A1908263 Hs 291625 ESTs 40

453282 AK000043 Hs 32922 hypothetical protein FU20036 40

440987 AA911705 Hs 130229 ESTs 38

443131 AI033833 Hs 132689 ESTs 38

431075 BE267477 gb 601189542F2 NIH MGC 7 Homo sapiens cDNA do 36

412637 AA115097 Hs 261313 ESTs 36

408141 U69205 Hs45152 ESTs, Moderately similar to neurogenic basic-helix-loop 35

420122 AA255714 Hs 284153 Fanconi anemia, complementation group A 35

430653 AW902062 Hs 30280 ESTs 34

401308 predicted exon 34

410758 BE535988 gb 601062418F1 NIH.MGC.10 Homo sapiens cDNAc 34

421418 AA806639 gb ob88g05 s1 NCI CGAP GCB1 Homo sapiens cDNA 34

450061 AI797034 Hs 201115 ESTs 33

409725 T40760 Hs 90459 EST 33

434738 AA836265 gb od17e02 s1 NCI.CGAP.GCB1 Homo sapiens cDNA 33

431644 AW972822 Hs 169248 cytochrome c 33

450938 AW753734 Hs 277215 ESTs 32

420497 AW206285 Hs 253548 ESTs 32

439426 AI131502 Hs 143135 ESTs, Weakly similarto FAFY.HUMAN PROBABLE C 32

407596 R86913 gb yq30f05 r1 Soares fetal liver spleen 1 NFLS Homo sap 32

448683 AA167642 Hs 14632 ESTs 32

431982 AW419296 Hs 105754 ESTs 3 1

452320 AA042873 Hs 160412 ESTs 31

419401 AW804663 gb QV4-UM0094-160300-135-d06 UM0094 Homo sapim 31

402105 predicted exon 31

444997 AI204451 Hs 146196 ESTs 31

403283 predicted exon 30

455388 AW936234 gb QVO-DT0020-090200-106-g05 DT0020 Homo sapie 30

428559 H24338 Hs 27041 ESTs 29

419002 T78625 Hs 268594 ESTs 29

404868 predicted exon 29

409090 W56067 Hs 103105 ESTs 29

406605 predicted exon 29

441202 AI632143 Hs 135853 ESTs 28

422046 AI638562 gb ts50a10 1 NCI.CGAP.Ut1 Homo sapiens cDNAcl 28

442865 N57659 Hs 114541 ESTs, Weakly similar to neuronal thread protein AD7c-N 28

444431 AW513324 Hs 42280 ESTs 28

426294 AA374185 gb EST86289 HSC172 cells I Homo sapiens cDNA 5' en 28

412480 BE142364 gb CMO-HT0143-270999-062-d12 HT0143 Homo sapie 28

449858 AW205979 Hs 196065 ESTs 28

401464 AF039241 Hs 9028 histone dexetylase 5 27

439126 AF085984 gb Homo sapiens full length insert cDNA clone YT99F0 27

403277 predicted exon 27

450078 A1681743 gb tx38g10 x1 NCI CGAP Lu24 Homo sapiens cDNA 27

458090 AI282149 Hs 56213 ESTs, Highly similar to FXD3 HUMAN FORKHEAD D 27

420620 AA278807 Hs 173343 ESTs 27

459054 AW798466 Hs 82396 2',5'-olιgoadenylate synthetase 1 26

421379 Y15221 Hs 103982 small inducible cytokine subfamily B (Cys-X-Cys), mem 26

454338 AW381251 Hs 1050 pleckstπn homology, Sec7 and coiled/coil domains 1(cyt 26

454529 Z45439 Hs 270425 ESTs 26

446877 AI559472 Hs 270720 ESTs 26

412588 AW993055 Hs 44024 ESTs 26

449862 AI672277 Hs 199475 ESTs 26

446694 AV659942 Hs 258132 ESTs 26

424029 AB014594 Hs 137579 KIAA0694 gene product 26 454102 AW752363 gb RCO-CT0201-270999 011-f03 CT0201 Homo sapien 26

430922 AW373747 Hs 183337 ESTs 26

420289 N55394 Hs 96398 8-oxoguanιne DNA glycosylase 26

410495 N95428 gb zb80d09 s1 Soares.senesceπt.fibroblasts.NbHSF Ho 25

412319 AW936903 gb RC1-DT0029 030200-012-d02 DT0029 Homo sapien 25

409699 BE154650 gb PM3 HT0344-071299-003-C08 HT0344 Homo sapien 25

445832 AI261545 gb qz30a07 x1 NCI.CGAP.KidH Homo sapiens cDNA 25

429755 NM 001364 Hs 215839 discs large (Drosophila) homolog 2 (chapsyπ 110) 25

445755 AW294870 Hs 223672 ESTs 25

TABLE 6B

Pkey Unique Eos probeset identifier number CAT number Gene cluster number Accession Genbank accession numbers

Pkey CAT Numbi Accession

407596 1003489 1 R86913 R86901 H25352 R01370 H43764 AW044451 W21298

409699 1149033 1 BE154650 BE154785 AW468343 BE154816 BE154667

410495 1205826 1 N95428 W24040AW751366 H81987

410758 1219899 1 BE535988 AW801777

412319 1288602 1 AW936903 AW936907 AW936908 AW936914

412480 129929 1 BE142364 BE142341 AA112025

419401 184454 1 AW804663 AW805017 AA236969

421418 202288 1 AA806639 AA291008 AA836274 AW978806

422046 210744 1 AI638562T16929 H13401 F07773 R55836

426294 263994 1 AA374185 AW956180 H38344

431075 327638 1 BE267477 AA491488 AW836723

434738 392562 1 AA836265 AA648266 AW974440

439126 46887 1 AF085984 H95905 H95906

445832 651925 1 AI261545 N59134 AW875371 AW875247

450078 823882 1 AI681743 AW897287 AW897205 AW897284

454102 1011603 1 AW752363 BE147120 N22640

455388 1287904 1 AW936234AW936074AW936181 AW936179 AW936217AW936077 AW936227 AW936191

TABLE 6C

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham I et al " refers to the publication entitled The DNA sequence of human chromosome 22" Dunham et al (1999) Nature 402489 495 Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons

401308 9212516 Plus 169019 169649

402105 8131588 Minus 22856-24055

403277 8072597 Minus 27494-27642

403283 8076905 Minus 71124-71996

404868 9454593 Plus 39954-40430

406605 8272666 Minus 23275-2349323723-23903

Table 7A lists about 770 genes up-regulated in ovanan cancer compared to normal adult tissues These were selected from 35403 probesets on the Affymetπx/Eos Hu01 GeneChip array such that the ratio of "average" ovanan cancer to "average" normal adult tissues was greater than or equal to 25 The "average" ovarian cancer level was set to the 2nd highest amongst various ovanan cancers The "average" normal adult tissue level was set to the 7th highest amongst various non malignant tissues In order to remove gene specific bxkgraund levels of non specific hybπdization the 15th percentile value amongst the non malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated

TABLE 7A ABOUT 770 UP REGULATED GENES, OVARIAN CANCER VERSUS NORMAL ADULT TISSUES

Pkey Pπmekey

Ex Accn Exemplar Accession

UG ID UniGeπe lD

Title UniGene Title ratio ration tumor vs normal tissues

Pkey Ex Accn UG ID Title ratio

109680 F09255 Hs 4993 ESTs 232

119743 W70242 Hs 58086 ESTs 220

132528 AA283006 Hs 50758 chromosome-associated polypeptide C 220

129571 X51630 Hs 1145 Wilms tumor 1 200

102151 U17280 Hs 3132 steroidogenic acute regulatory protein 196

130941 D49394 Hs 2142 5 hydroxytryptamine (serotonin) receptor 3A 175

132624 AA164819 Hs 53631 ESTs 159

102610 U65011 Hs 30743 preferentially expressed antigen in melanoma 154

101249 L33881 Hs 1904 protein kinase C, iota 145

122802 AA460530 Hs 256579 ESTs 145

135242 M74093 Hs 9700 cyclm E1 138

101804 M86699 Hs 169840 TTK protein kinase 122

123005 AA479726 Hs 105577 ESTs 120

114965 AA250737 Hs 72472 ESTs 11 5

115536 AA347193 Hs 62180 ESTs 11 4

132191 AA449431 Hs 158688 KIAA0741 gene product 109

121853 AA425887 Hs 98502 ESTs 109

115881 AA435577 Hs 184942 G protein-coupled receptor 64 108

119780 W72967 Hs 191381 ESTs, Weakly similar to hypothetical protein 105

104301 D45332 Hs 6783 ESTs 103

132632 N59764 Hs 5398 guaπine-monophosphate synthetase 101 105298 AA233459 Hs 26369 ESTs 97

108857 AA133250 Hs 62180 ESTs 91

113168 T53592 Hs 161586 EST 90

115892 AA435946 Hs 50831 ESTs 89

125666 AA199856 Hs 118811 ESTs 89

102200 U21551 Hs 157205 branched chain ammotransferase 1, cytosolic 88

108055 AA043562 Hs 62637 ESTs 86

132572 AA448297 Hs 237825 signal recognition particle 72kD 86

115909 AA436666 Hs 59761 ESTs 85

109166 AA179845 Hs 73625 RAB6 interacting, kinesiπ like (rabkinesmδ) 83

121779 AA422036 Hs 98367 ESTs 83

102915 X07820 Hs 2258 matrix metalloprotemase 10 (stromelysin 2) 80

105317 AA233926 Hs 23635 ESTs 78

125250 W87465 Hs 222926 ESTs, Weakly similar to D20922 [C elegans] 78

126960 AA317900 Hs 161756 ESTs 78

122969 AA478539 Hs 104336 ESTs 77

130376 R40873 Hs 155174 KIAA0432 gene product 77

123339 AA504253 Hs 101515 ESTs 77

134972 M19720 Hs 169252 Human L-myc protein gene, complete eds 76

111234 N69287 Hs 21943 ESTs, Weakly similar to ORF YGL221c [S cerevi 75

123689 AA609556 Hs 256562 ESTs 75

123494 AA599786 Hs 112110 ESTs 74

131985 AA434329 Hs 36563 ESTs 74

106738 AA470145 Hs 25130 ESTs 74

108768 AA127741 Hs 61345 ESTs , 73

106474 AA450212 Hs 42484 Homo sapiens mRNA, cDNA DKFZp564C053 (from cl 72

123308 AA496211 Hs 103538 ESTs 72

106124 AA423987 Hs 7567 ESTs 72

111345 N89820 Hs 14559 ESTs 7 1

105200 AA195399 Hs 24641 ESTs 7 1

116416 AA609219 Hs 39982 ESTs 71

118846 N80567 Hs 50895 ESTs 71

133434 AA278852 Hs 250786 ESTs 71

120472 AA251875 Hs 104472 ESTs, Weakly similar to Gag-Pol polyprotein [ 69

115291 AA279943 Hs 122579 ESTs 69

111185 N67551 Hs 12844 EGF like-domain, multiple 6 69

108778 AA128548 Hs 90847 general transcπption factor IIIC, polypeptid 69

132939 U76189 Hs 61152 exostoses (multiple) like 2 69

134520 N21407 Hs 257325 ESTs 69

114724 AA131701 Hs 256287 ESTs, Highly similar to SPERM SURFACE PROTEIN 68

116296 AA489033 Hs 62601 Homo sapiens mRNA, cDNA DKFZp586K1318 (from c 68

102136 U15552 Hs 85769 acidic 82 kDa protein mRNA 67

132725 L41887 Hs 184167 splicing factor, argiπine/seππe rich 7 (35kD 65

109648 F04600 Hs 7154 ESTs 64

116401 AA599963 Hs 59698 ESTs 64

127563 AI367707 Hs 150587 ESTs 64

104252 AF002246 Hs 210863 cell adhesion molecule with homology to L1CAM 64

120438 AA243441 Hs 99488 ESTs, Weakly similar to ORF YKR074w [S cerevi 62

131978 D80008 Hs 36232 KIAA0186 gene product 62

134621 L02547 Hs 172865 cleavage stimulation factor; 3' pre-RNA, subu 62

120571 AA280738 Hs 128679 ESTs 62

102627 U66561 Hs 158174 zinc finger protein 184 (Kruppel like) 61

100661 HG2874-HT3018 Ribosomal Protein L39 Homolog 61

118204 N59859 Hs 48443 ESTs 60

131386 AA096412 Hs 173135 dual specificity tyrosιne-(Y)-phosphorylatιon 60

129097 S50223 HKR-T1=Kruppel like zinc finger protein [huma 59

131228 AA279157 Hs 24485 chondroitm sulfate proteoglycan 6 (bamacan) 59

106369 AA443828 Hs 25324 ESTs 59

108255 AA063157 Hs 172608 ESTs 58

125370 AA256743 Hs 151791 KIAA0092 gene product 58

130010 N52966 Hs 142838 ESTs 58

131945 M87339 Hs 35120 replication factor C (activator 1) 4 (37kD) 57

116238 AA479362 Hs 47144 DKFZP586N0819 protein 57

102221 U24576 UM domain only 4 56

130757 R00641 Hs 8925 ESTs, Weakly similar to cDNA EST yk339a7 5 co 56

131278 U81523 Hs 25195 eπdometπal bleeding associated factor (left- 56

101383 M14113 Hs 79345 coagulation factor Vlllc, procoagulantcompon 55

131836 AA610086 Hs 32990 DKFZP566F084 protein 55

129628 U26727 Hs 1174 cyclm-dependent kinase inhibitor 2A (melanom 55

106523 AA453441 Hs 31511 ESTs 55

111772 R28287 Hs 237146 ESTs 55

101255 L34600 Hs 149894 mitochondπal translational initiation factor 55

106895 AA489665 Hs 25245 ESTs 55

104943 AA065217 Hs 169674 ESTs 55

129229 AA211941 Hs 109643 polyadenylate binding protein interacting pro 54

102305 U33286 Hs 90073 chromosome segregation 1 (yeast homolog)-lιke 54

106553 AA454967 Hs 5887 ESTs, Highly similar to RNA binding motif pro 54

112305 R54822 Hs 26244 ESTs 53

123972 C14782 Hs 70337 immunoglobulin superfamily member 4 53

102676 U72514 Hs 12045 putative protein 53

106459 AA449741 Hs 4029 glioma-amplified sequence-41 52

107865 AA025104 Hs 61252 ESTs 52

121121 AA399371 Hs 189095 ESTs, Weakly similar to zinc finger protein S 52

127162 N76398 Hs 21187 ESTs 52 131646 AA171895 Hs.30057 Homo sapiens clone 24749 and 24750 mRNA seque 5.2

121770 AA421714 Hs.11469 KIAA0896 protein 5.2

122512 AA449311 Hs.98658 budding uninhibited by beπzimidazoles 1 (yeas 5.1

105870 AA399623 Hs.23505 ESTs 5.1

100341 D63506 Hs.8813 syπtaxin binding protein 3 5.1

116848 H65187 Hs.39001 ESTs 5.1

120821 AA347419 Hs.96870 Homo sapiens mRNA full length insert cDNA clo 5.1

130690 AA084286 Hs.139033 paternally expressed gene 3 5.1

122661 AA454936 Hs.245541 ESTs 5.1

123169 AA488892 Hs.104472 ESTs; Weakly similar to Gag-Pol polyprotein [ 5.1

108810 AA130596 Hs.71331 ESTs; Weakly similar to POTENT HEAT-STABLE PR 5.0

110799 N26101 Hs.7838 Human ring zinc-finger protein (ZNF127-Xp) ge 5.0

120619 AA284372 Hs.111471 ESTs 5.0

122792 AA460225 Hs.99519 ESTs 5.0

129912 AA047344 Hs.107213 ESTs; Highly similar to NY-REN-6 antigen [H.s 5.0

102823 U90914 Hs.5057 carboxypeptidase D 4.9

129890 M13699 Hs.111461 ceruloplasmin (ferroxidase) 4.9

101084 L05425 Homo sapiens autoantigen mRNA; complete eds 4.9

134859 D87716 Hs.90315 KIAA0007 protein 4.9

115955 AA446121 Hs.44198 Homo sapiens BAC clone RG054D04 from 7q31 4.9

105516 AA257971 Hs.21214 ESTs 4.9

114932 AA242751 Hs.16218 KIAA0903 protein 4.9

106672 AA461300 Hs.30643 ESTs 4.8

106126 AA424006 Hs.22972 ESTs; Moderately similar to H5AR [M.musculus] 4.8

110695 H93463 Hs.124777 ESTs ^ 4.8

102025 U03911 Hs.78934 mutS (E. coli) homolog 2 (colon cancer; nonpo 4.8

133282 U52960 Hs.250855 SRB7 (suppressor of RNA polymerase B; yeast) 4.8

119708 W67810 Hs.57904 mago-nashi (Drosophila) homolog; praliferatio 4.7

120695 AA291468 ESTs 4.7

128651 AA446990 Hs.103135 ESTs 4.7

103152 X66533 Hs.77890 guanylate cyclase 1; soluble; beta 3 4.7

108699 AA121514 Hs.70332 ESTs 4.7

115094 AA255921 Hs.88095 ESTs 4.7

121429 AA406293 Hs.193498 ESTs 4.7

123203 AA489671 Hs.89709 glutamate-cysteine ligase (gamma-glutamylcyst 4.7

126802 AA947601 Hs.97056 ESTs 4.7

130527 C17384 Hs.184227 F-box protein 21 4.7

134470 X54942 Hs.83758 CDC28 protein kinase 2 4.7

100449 D87470 Hs.75400 KIAA0280 protein 4.7

110970 N51374 Hs.96870 Homo sapiens mRNA full length insert cDNA clo 4.7

115901 AA436403 Hs.86909 ESTs; Moderately similar to Frizzled-6 [H.sap 4.7

109799 F10770 Hs.180378 Homo sapiens clone 669 unknown mRNA; complete 4.6

116195 AA465148 Hs.72402 ESTs 4.6

132122 U65092 Hs.40403 Cbp/p300-interacting transxtivator; with Glu 4.6

108990 AA152296 Hs.72045 ESTs 4.6

109055 AA160529 Hs.48524 ESTs 4.6

115937 AA443269 Hs.30991 KIAA0957 protein 4.6

133520 X74331 Hs.74519 primase; polypeptide 2A (58kO) 4.6

131200 AA609427 Hs.210706 ESTs; Moderately similar to III! ALU SUBFAMIL 4.6

121369 AA405657 Hs.128791 Human DNA sequence from clone 967N21 on chrom 4.5

132880 AA444369 Hs.177537 ESTs 4.5

127386 AI457411 Hs.106728 ESTs 4.5

120067 W93592 Hs.47343 ESTs 4.5

122986 AA479063 Hs.102947 ESTs 4.5

135286 AA401269 Hs.97849 ESTs 4.5

130155 L33404 Hs.151254 kallikrein 7 (chymotryptic; stratum comeum) 4.5

106103 AA421104 Hs.12094 ESTs 4.5

102654 U68494 Hs.24385 Human hbc647 mRNA sequence 4.4

107876 AA025315 Hs.61184 Novel human gene mapping to chomosome X 4.4

109454 AA232255 Hs.46912 ESTs 4.4

125960 D63307 Hs.145968 ESTs 4.4

126892 AI160190 Hs.76127 hect (homologous to the E6-AP (UBE3A) carboxy 4.4

100269 D38550 Hs.1189 E2F transcription factor 3 4.4

134161 U97188 Hs.79440 IGF-II mRNA-biπding protein 3 4.3

100502 HG1496-HT1496 Adrenal-Specific Protein Pg2 4.3

105542 AA261858 Hs.8241 ESTs; Weakly similar to heat shock protein hs 4.3

109787 F10610 Hs.34853 inhibitor of DNA binding 4; dominant negative 4.3

110759 N21671 Hs.19025 ESTs 4.3

129970 AA478975 Hs.200434 ESTs 4.3

134666 AA482319 Hs.8752 putative type II membrane protein 4.3

117693 N40939 Hs.44162 ESTs; Weakly similar to cDNA EST yk342h12.5 c 4.3

111008 N53388 Hs.7222 ESTs 4.3

120977 AA398155 Hs.97600 ESTs 4.2

105808 AA393808 Hs.21490 KIAA0438 gene product 4.2

121381 AA405747 Hs.97865 ESTs; Weakly similar to WASP-family protein [ 4.2

100893 HG4557-HT4962 Small Nuclear Ribonucleoprotein U1, 1snrp 4.2

107176 AA621762 Hs.7576 ESTs 4.2

118976 N93629 Hs.93391 ESTs 4.2

130703 N63295 Hs.18103 ESTs 4.2

106540 AA454607 Hs.38114 ESTs; Weakly similar to coded for by C. elega 4.2

119367 T78324 Hs.90905 ESTs 4.2

133633 D21262 Hs.75337 nucleolar phosphoprotein p130 4.2

105520 AA258068 Hs.33085 WD repeat domain 3 4.2

114264 Z40074 Hs.27595 . ESTs 4.1 131046 X02530 Hs 2248 IP10, 'small inducible cytokine subfamily B ( 4 1

105220 AA210695 Hs 17212 ESTs 41

103111 X63187 Hs 2719 epididymis specific, whey acidic protein type 41

125640 R37700 Hs 208261 ESTs 41

110561 H59617 Hs 5199 ESTs, Weakly similar to UBIQUITIN CONJUGATING 41

118092 N54915 Hs 82719 Homo sapiens mRNA, cDNA DKFZp586F1822 (from c 41

134891 F03517 Hs 90787 ESTs 41

112364 R59312 Hs 197642 ESTs, Weakly similar to DNA-DIRECTED RNA POLY 41

120699 AA291716 Hs 97258 ESTs 41

106272 AA432074 Hs 32538 ESTs 41

112041 R43300 Hs 22929 ESTs 41

131689 AA599653 Hs 30696 transcription factor-like 5 (basic helix-loop 41

116134 AA460246 Hs 50441 ESTs, Highly similarto CGI 04 protein [H sap 41

107638 AA009528 Hs 42743 ESTs, Weakly similar to predicted using Genef 40

131941 D62657 Hs 35086 ubiquitm specific protease 1 40

106154 AA425304 Hs 6994 ESTs 40

105546 AA262032 Hs 26089 ESTs, Weakly similar to 62D9 a [D melanogaste 40

106319 AA436606 Hs 7392 ESTs, Weakly similar to Gu protein [H sapiens 40

121816 AA424814 Hs 187509 ESTs 40

122851 AA463627 Hs 99598 ESTs 40

123337 AA504153 Hs 132797 ESTs, Weakly similar to ORF YGL050w [S cerevi 40

128643 N40212 Hs 102958 ESTs 40

129011 S72869 Hs 107932 DNA segment, single copy, probe pH4 (transfer 40

130895 AA609828 Hs 21015 ESTs, Highly similar to tetπacycline traπspor 40

132323 AA436102 Hs 256559 ESTs ._ 40

134255 J05032 Hs 80758 aspartyl tRNA synthetase 40

102827 U91327 Hs 6456 chaperonin containing TCP1, subunit 2 (beta) 40

102123 U14518 Hs 1594 centromere protein A (17kD) 40

102813 U90651 Hs 151461 embryonic ectoderm development protein 39

113970 W86748 Hs 8109 ESTs 39

107145 AA621108 Hs 173001 ESTs 39

114212 Z39338 Hs 21201 DKFZP566B0846 protein 39

106614 AA458934 Hs 179912 ESTs 39

132742 AA490862 Hs 55901 ESTs, Weakly similar to C43H8 1 [C elegans] 39

120948 AA397822 Hs 104650 ESTs, Highly similar to similar to mago nashi 39

129337 R63542 Hs 110488 KIAA0990 protein 39

103835 AA172215 Hs 93748 ESTs, Moderately similar to TRANSCRIPTION FAC 39

133330 U42360 Hs 71119 Putative prostate cancer tumor suppressor 39

133928 N34096 Hs 7766 ubiquitiπ-conjugatmg enzyme E2E 1 (homologou 39

133640 083004 Hs 75355 ubiquitiπ-conjugating enzyme E2N (homologous 39

133350 AA135468 Hs 71573 ESTs 39

115623 AA401475 Hs 39733 postsynaptic protein CRIPT 39

101973 S82597 Hs 80120 UDP-N acetyl-alpha-D-galactosamine polypeptid 39

102669 U71207 Hs 29279 eyes absent (Drosophila) homolog 2 39

134248 AA292677 Hs 80624 ESTs 39

102380 U40434 Hs 155981 mesothelin 39

116157 AA461063 Hs 44298 ESTs, Highly similar to HSPC011 [H sapiens] 38

106691 AA463453 Hs 23259 ESTs, Weakly similar to ACTIN, CYTOPLASMIC 2 38

115844 AA430124 Hs 234607 ESTs 38

107159 AA621340 Hs 10600 ESTs, Weakly similar to ORF YKR081c [S cerevi 38

106498 AA452141 Hs 7171 ESTs 38

134405 J04177 Hs 82772 collagen, type XI, alpha 1 38

106260 AA431448 Hs 5250 ESTs, Weakly similar to BACR37P7 g [D melanog 38

109864 H02554 Hs 30323 ESTs 38

124648 N91948 Hs 125034 ESTs 38

134719 L07515 Hs 89232 chromobox homolog 5 (Drosophila HP1 alpha) 38

113702 T97307 Hs 161720 ESTs, Moderately similar to "« ALU SUBFAMIL 38

128639 N91246 Hs 102897 ESTs 38

111299 N73808 Hs 24936 ESTs 37

129351 AA167268 Hs 62349 Human ras inhibitor mRNA, 3' end 37

119741 W70205 Hs 43670 kinesin family member 3A 37

105012 AA116036 Hs 9329 chromosome 20 open reading frame 1 37

128734 AA343629 Hs 104570 kallikrem 8 (neuropsin/ovasiπ) 37

130567 L07493 Hs 1608 replication protein A3 (14kD) 37

114253 Z39909 Hs 14831 ESTs 37

103169 X68560 Hs 44450 Sp3 transcπptioπ factor 37

111269 N70711 Hs 18885 ESTs, Highly similar to CG1 116 protein [H sa 37

112876 T03488 Hs 4842 ESTs 37

118261 N62780 Hs 94122 ESTs 37

130385 AA126474 Hs 155223 stanniocalcin 2 37

129300 C20976 Hs 110165 ESTs, Highly similar to πbosomal protein L26 37

134388 M15841 Hs 82575 small nuclear πbonucleoprotein polypeptide B 37

106968 AA504631 Hs 26813 ESTs, Weakly similar to hypothetical 43 2 kDa 37

100906 HG4716-HT5158 Guanosine 5'-Monophosphate Synthase 37

100418 D86978 Hs 84790 KIAA0225 protein 37

101484 M24594 Hs 20315 interferon induced protein 56 37

102547 U57911 Hs 46638 chromosome 11 open reading frame 8 37

103587 Z29083 Hs 82128 5T4 oncofetal trophoblast glycoprotein 37

130600 AA478601 Hs 258737 ESTs 37

128733 AA328993 Hs 104558 ESTs 37

134375 AA412720 Hs 82389 ESTs, Highly similar to CGI-118 protein [H sa 37

134098 X06323 Hs 79086 πbosomal protein, mitochondπal, L3 36

101188 L20320 Hs 184298 cyclm-dependent kinase 7 (homolog of Xenopus 36

132149 T10822 Hs 4095 ESTs 36 116200 AA465358 Hs 118793 ESTs, Highly similar to p621 [H sapiens] 36

121920 AA428300 Hs 161841 ESTs 36

128609 AA234365 Hs 102456 survival of motor neuron protein interacting 36

101078 L04510 Hs 792 ADP-πbosylation factor domain protein 1, 64k 36

108693 AA121289 Hs 49597 ESTs, Highly similar to ret oic acid-induced 36

109139 AA176121 Hs 59757 zinc finger protein 281 36

111870 R37778 Hs 18685 ESTs, Weakly similar to hypothetical protein 36

113848 W60080 Hs 27099 DKFZP564J0863 protein 36

127947 AI432475 Hs 146327 ESTs 36

128056 AI379480 Hs 125449 ESTs, Weakly similar to MaxiK channel beta 2 36

129914 U22377 Hs 13321 rearranged L-myc fusion sequence 36

132148 AA283988 Hs 4094 ESTs 36

134644 S83308 Hs 87224 SRY (sex determining region Y)-box 5 36

115047 AA252627 Hs 22554 homeo box B5 36

102398 U42359 Human N33 protein form 1 (N33) gene, exon 1 a 36

127479 AA513722 Hs 179729 collagen, type X, alpha 1 (Schmid metaphyseal 36

105545 AA262030 Hs 5152 ESTs, Weakly similar to katanm p80 subunit [ 36

101483 M24486 Hs 76768 procollagen-prolme, 2-oxoglutarate 4-dιoxyge 36

105709 AA291268 Hs 26761 DKFZP586L0724 protein 36

122636 AA454103 Hs 110031 ESTs 36

124792 R44357 Hs 132784 ESTs, Weakly similar to cDNA EST EMBL T01421 36

103621 Z47727 Hs 150675 polymerase (RNA) II (DNA directed) polypeptid 35

105427 AA251330 Hs 28248 ESTs 35

121553 AA412488 Hs 48820 ESTs 35

115167 AA258421 Hs 43728 hypothetical protein 35

134570 U66615 Hs 172280 SWI/SNF related, matrix associated, actin dep 35

110787 N24716 Hs 12244 ESTs, Weakly similar to C44B9 1 [C elegans] 35

131621 U77665 Hs 139120 πbonuclease P (30kD) 35

132813 N72116 Hs 57435 solute camerfamily 11 (proton-coupled diva 35

116370 AA521256 Hs 236204 ESTs, Moderately similarto NUCLEAR PORE COMP 35

131965 W90146 Hs 35962 ESTs 35

115221 AA262942 Hs 9741 ESTs 35

116093 AA456020 Hs 50848 ESTs, Weakly similar to KIAA0862 protein [H s 35

123507 AA600176 Hs 112345 ESTs 35

129801 F11087 Hs 239666 ESTs 35

115084 AA255566 Hs 42484 Homo sapiens mRNA, cDNA DKFZp564C053 (from cl 35

123442 AA598803 Hs 111496 ESTs 35

115061 AA253217 Hs 41271 ESTs 35

100146 D13645 Hs 2471 KIAA0020 gene product 35

115140 AA258030 Hs 55356 ESTs, Weakly similar to supported by GENSCAN 35

115360 AA281950 Hs 5057 carboxypeptidase D 35

130261 D83767 Hs 153678 reproduction 8 34

100824 HG4058-HT4328 Oncogene Am!1-Evι-1, Fusion Activated 34

102287 U31814 Hs 3352 histone deacetylase 2 34

102788 U86602 Hs 74407 nucleolar protein p40 34

118836 N79820 Hs 50854 ESTs 34

102423 U44754 Hs 179312 small nuclear RNA activating complex, polypep 34

106300 AA435840 Hs 19114 high mobility group (nonhistone chromosomal) 34

106156 AA425354 Hs 4210 ESTs 34

106483 AA451676 Hs 30299 IGF-II mRNA-biπdmg protein 2 34

107868 AA025234 Hs 61260 ESTs 34

108187 AA056538 Hs 27842 ESTs, Weakly similar to similar to 1-acyl-gly 34

116123 AA459282 Hs 43756 ESTs 34

119501 W37721 Hs 151363 ESTs 34

129121 AA127459 Hs 108788 ESTs, Weakly similar to zeste [D melanogaster 34

131638 D87120 Hs 29882 predicted osteoblast protein 34

132962 N34893 Hs 6153 ESTs, Highly similar to CGI-48 protein [H sap 34

133767 D63875 Hs 173288 KIAA0155 gene product 34

111823 R35253 Hs 24944 ESTs 34

134372 D63877 Hs 82324 KIAA0157 protein 34

130938 AA013250 Hs 21398 ESTs, Moderately similar to PUTATIVE GLUCOSAM 34

115169 AA258427 Hs 58427 ESTs 34

123978 C20653 Hs 170278 ESTs 34

108807 AA129968 Hs 49376 ESTs, Weakly similar to PROTEIN PHOSPHATASE P 34

132581 R42266 Hs 52256 ESTs, Weakly similar to beta-TrCP protein E3R 34

134654 W23625 Hs 8739 ESTs, Weakly similar to ORF YGR200c [S cerevi 34

105730 AA292701 Hs 5364 DKFZP564I052 protein 34

111295 N73275 Hs 21275 ESTs, Weakly similar to ubiquitiπ-conjugating 33

102009 U02680 Hs 82643 protein tyrosine kinase 9 33

114161 Z38904 Hs 22385 ESTs, Weakly similarto KIAA0970 protein [H s 33

130604 X03635 Hs 1657 estrogen receptor 1 33

100103 AF007875 Hs 5085 dolichyl-phosphate maπnosyltransferase polype 33

121748 AA421171 Hs 234545 ESTs 33

106698 AA463745 Hs 29403 ESTs, Weakly similar to PROBABLE ATP-DEPENDEN 33

134353 S77154 Hs 82120 nuclear receptor subfamily 4, group A, member 33

134154 AA211320 Hs 79404 neuron-specific protein 33

133142 F03321 Hs 65874 ESTs 33

124461 N50641 Hs 80285 Homo sapiens mRNA, cDNA DKFZp586C1723 (from c 33

104903 AA055534 Hs 124134 ESTs 33

106772 AA478106 Hs 12692 ESTs, Weakly similar to protein phosphatase-1 33

109704 F09687 Hs 12876 ESTs 33

111131 N64267 Hs 10177 ESTs 33

115019 AA251906 Hs 48473 ESTs 33

116019 AA450312 Hs 237480 Homo sapiens mRNA, cDNA DKFZp434E102 (from cl 33 118528 N67889 Hs 49397 ESTs 33

124027 F03625 Hs 107537 ESTs 33

131699 R68657 Hs 90421 ESTs, Moderately similar to «« ALU SUBFAMIL 33

111044 N55443 Hs 23625 ESTs 33

103768 AA089997 Hs 180320 ESTs, Weakly similar to GOLGl 4-TRANSMEMBRANE 33

131882 N49091 Hs 3385 ESTs, Highly similar to CGI-134 protein [H sa 33

123673 AA609471 Hs 112712 ESTs 33

132936 AB002305 Hs 6111 KIAA0307 gene product 33

103023 X53793 Hs 117950 multifunctional polypeptide similar to SAICAR 33

120572 AA280794 Hs 258787 ESTs 33

132384 AA479933 Hs 46967 Human DNA sequence from clone 167A19 on chrom 33

105658 AA282914 Hs 10176 ESTs 32

105086 AA147719 Hs 159441 ESTs 32

118695 N71781 Hs 50081 Homo sapiens mRNA full length insert cDNA clo 32

112092 R44538 Hs 140889 ESTs 32

125154 W38419 Hs 24936 ESTs 32

108040 AA041551 Hs 48644 ESTs 32

133453 M68941 Hs 73826 protein tyrosine phosphatase, non receptor ty 32

124006 D60302 Hs 108977 ESTs 32

116083 AA455653 Hs 44581 ESTs, Weakly similar to HEAT SHOCK 70 KD PROT 32

106753 AA476944 Hs 7331 ESTs 32

102621 U66075 Hs 50924 GATA binding protein 6 32

103330 X85373 Hs 77496 small nuclear πbonucleoprotein polypeptide G 32

128926 AA481403 Hs 107213 ESTs, Highly similar to NY-REN 6 antigen [H s 32

101167 L15309 Hs 193677 zinc finger protein 141 (clone pHZ-44) 32

104055 AA393755 Hs 117211 ESTs, Highly similarto CGI-62 protein [H sap 32

112917 T10196 Hs 4263 ESTs, Weakly similar to /prediction 32

120358 AA213459 Hs 100932 franscπption factor 17 32

121857 AA426017 Hs 62694 ESTs, Highly similarto DNA-REPAIR PROTEIN CO 32

122124 AA434257 Hs 186679 ESTs, Moderately similar to "" ALU SUBFAMIL 32

132231 H99131 Hs 42635 ESTs 32

134272 X76040 Hs 223014 protease serine, 15 32

115860 AA431719 Hs 61809 ESTs 32

115278 AA279757 Hs 67466 ESTs, Weakly similar to BACN32G11 d [D melaπo 32

134125 R38102 Hs 50421 KIAA0203 gene product 32

129160 AA131252 Hs 109007 ESTs 32

121710 AA419011 Hs 96744 DKFZP586D0823 protein 32

102242 U27185 Hs 32943 retinoic acid receptor responder (tazarotene 32

104956 AA074880 Hs 120975 ESTs, Weakly similar to hypothetical protein 32

113047 T25867 Hs 7549 ESTs 32

115017 AA251880 Hs 179982 tumor protein p53 binding protein 32

133780 M14219 Hs 76152 decoππ 31

129453 AA421213 Hs 111632 Lsm3 protein 3 1

130353 X86018 Hs 172210 MUF1 protein 3 1

106036 AA412505 Hs 10653 ESTs 31

102234 U26312 Hs 8123 chromobox homolog 3 (Drosophila HP1 gamma) 31

106133 AA424346 Hs 107573 sialyltransferase 31

116803 H47357 ESTs Moderately similar to weak similaπty t 3 1

106721 AA465194 Hs 6670 ESTs 3 1

107115 AA610108 Hs 27693 ESTs, Highly similar to CGI-124 protein [H sa 31

133228 N90029 Hs 6831 Homo sapiens clone 1400 unknown protein mRNA 31

104733 AA019498 Hs 23071 ESTs 3 1

103879 AA228148 Hs 50252 ESTs, Weakly similar to putative [C elegans] 3 1

103038 X54941 Hs 77550 CDC28 protein kinase 1 31

135154 AA126433 Hs 173242 sorting nexin 4 3 1

114860 AA235112 Hs 106227 ESTs, Moderately similar to similar to muπne 3 1

102437 U46569 Hs 221986 aquapoπn 5 31

100352 D64159 Homo sapiens mRNA for 3-7 gene product, parti 31

103631 Z48570 H sapiens Spl 7 gene 31

104238 AB002364 Hs 27916 a dismtegπn-like and metalloprotease (repro 31

108613 AA100967 Hs 69165 ESTs 31

115915 AA436884 Hs 48926 ESTs 31

120640 AA286945 Hs 163933 ESTs 31

124068 H03099 Hs 101619 ESTs 3 1

130375 U91931 Hs 155172 adaptor-related protein complex 3, beta 1 sub 31

131632 AA443671 Hs 29826 ESTs 31

131523 H88801 Hs 201676 M phase phosphopratein 10 (U3 small nucleolar 31

115827 AA427890 Hs 44426 ESTs, Weakly similar to PHOSPHOUPID HYDROPER 31

108828 AA131584 Hs 71435 DKFZP564O0463 protein 31

112198 R49483 Hs 22159 ESTs, Weakly similar to ZINC FINGER PROTEIN H 31

123960 AA621785 Hs 170008 methylmalonate semialdehyde dehydrogenase 3 1

131538 Z29331 Hs 28505 ubiquitin-conjugating enzyme E2H (homologous 31

105616 AA280670 Hs 24968 ESTs 31

101228 L27706 Hs 82916 chaperoniπ containing TCP1, subunit 6A (zeta 31

100280 D42085 Hs 155314 KIAA0095 gene product 31

132744 X54326 Hs 55921 glutamyl prolyl tRNA synthetase 31

103105 X61970 Hs 76913 proteasome (prosome, macropain) subunit alph 31

106984 AA521201 Hs 7129 ESTs 31

105127 AA158132 Hs 11817 ESTs Weakly similar to contains similaπty t 3 1

102302 U33052 Hs 69171 protein kinase C-like 2 31

117708 N45114 Hs 46476 ESTs 31

111314 N74574 Hs 33922 H sapiens novel gene from PAC 117P20, chromos 30

132902 AA490969 Hs 168147 ESTs 30

130356 X84373 Hs 155017 nuclear receptor interacting protein 1 30 128420 AI088155 Hs.14146 ESTs; Weakly similar to unknown [H.sapiens] 3.0

108746 AA126974 Hs.43388 ESTs 3.0

127236 AI341818 Hs.98658 budding uninhibited by benzimidazoles 1 (yeas 3.0

114208 Z39301 Hs.7859 ESTs 3.0

107071 AA609053 Hs.35198 ESTs 3.0

104957 AA074919 Hs.10026 ESTs; Weakly similar to ORF YJL063c [S.cerevi 3.0

124073 H05394 Hs.127376 KIAA0266 gene product 3.0

130869 AA128100 Hs.2057 uridiπe monophosphate synthetase (orotate pho 3.0

101232 L28997 Hs.242894 ADP-ribosylatioπ factor-like 1 3.0

104276 C02193 Hs.85222 ESTs; Weakly similar to R27090.2 [H.sapiens] 3.0

126160 N90960 Hs.247277 ESTs; Weakly similar to transformation-relate 3.0

128584 M11433 Hs.101850 retinol-bindiπg protein 1; cellular 3.0

100405 D86425 Hs.82733 nidogen 2 3.0

101335 L49054 Homo sapiens t(3;5)(q25.1;p34) fusion gene NP 3.0

108761 AA127514 Hs.61603 ESTs 3.0

111346 N89829 Hs.13259 ESTs 3.0

114988 AA251089 Hs.94576 ESTs; Weakly similar to phosducin; retinal [H 3.0

116008 AA449338 Hs.48589 ESTs; Weakly similar to finger protein HZF6; 3.0

116545 D20313 Hs.74899 ESTs 3.0

117873 N49967 Hs.46624 ESTs 3.0

121463 AA411745 Hs.239681 ESTs; Weakly similar to KIAA0554 protein [H.s 3.0

128625 AA242816 Hs.102652 ESTs; Weakly similar to KIAA0437 [H.sapiens] 3.0

131185 M25753 Hs.23960 cyclin B1 3.0

134380 D38073 Hs.179565 minichromosome maintenance deficient (S. cere 3.0

105740 AA293206 Hs.10852 ESTs .., 3.0

130919 AA291710 Hs.21276 collagen; type IV; alpha 3 (Goodpasture antig 3.0

134423 W96151 Hs.83006 ESTs; Highly similarto CGI-139 protein [H.sa 3.0

104896 AA054228 Hs.23165 ESTs 3.0

134407 X72964 Hs.82794 caltractin (20kD calcium-binding protein) 3.0

106378 AA445994 Hs.21331 ESTs 3.0

112283 R53545 Hs.20952 Homo sapiens clone 24411 mRNA sequence 3.0

109018 AA156960 Hs.114992 ESTs 3.0

114239 Z39742 Hs.222478 ESTs 3.0

114969 AA250775 Hs.87747 ESTs 3.0

116408 AA608752 Hs.71969 Homo sapiens mRNA; cDNA DKFZp564P0823 (from c 3.0

115286 AA279803 Hs.82204 ESTs 2.9

105809 AA393827 Hs.20104 ESTs 2.9

113811 W44928 Hs.4878 ESTs 2.9

107248 D59894 Hs.34782 ESTs 2.9

134489 U09284 Hs.112378 UM and senescent cell antigen-like domains 1 2.9

134064 D87685 Hs.78893 KIAA0244 protein 2.9

127370 AI024352 Hs.70337 immunoglobulin superfamily; member 4 2.9

113277 T65797 Hs.11774 protein (peptidyl-prolyl cis/trans isomerase) 2.9

132783 N74897 Hs.5683 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 2.9

109010 AA156460 Hs.44229 dual specificity phosphatase 12 2.9

130095 F01831 Hs.14838 ESTs 2.9

106618 AA459249 Hs.8715 ESTs; Weakly similar to Similarity with snail 2.9

103427 X97303 H.sapiens mRNA for Ptg-12 protein 2.9

133980 D00760 Hs.181309 proteasome (prosome; macropain) subunit; alph 2.9

111353 N90430 Hs.6616 ESTs 2.9

105344 AA235303 Hs.8645 ESTs 2.9

134498 M63180 Hs.84131 threonyl-tRNA synthetase 2.9

117910 N50828 Hs.12940 zinc-fingers and homeoboxes 1 2.9

118903 N90774 Hs.132207 ESTs; Moderately similar to III! ALU SUBFAMIL 2.9

121713 AA419198 Hs.105577 ESTs 2.9

129080 H19307 Hs.108507 ESTs 2.9

129404 AA172056 Hs.111128 ESTs 2.9

129457 X55330 Hs.207776 aspartylglucosamiπidase 2.9

130352 D87450 Hs.154978 KIAA0261 protein 2.9

133415 X69699 Hs.73149 paired box gene 8 2.9

120649 AA287115 Hs.99697 ESTs 2.9

131257 AA256042 Hs.24908 ESTs 2.9

134480 AA024664 Hs.83916 NADH dehydrogenase (ubiquinone) 1 alpha subco 2.9

116734 F13789 Hs.93796 DKFZP586D2223 protein 2.9

105028 AA126719 Hs.25282 ESTs 2.9

114986 AA251010 Hs.87807 ESTs 2.9

105651 AA282481 Hs.18439 ESTs 2.9

101714 M68874^' Human phosphatidylcholine 2-acylhydralase (cP 2.9

123398 AA521265 Hs.105514 ESTs 2.9

106007 AA411462 Hs.11042 ESTs; Weakly similar to veli 1 [H.sapiens] 2.9

109450 AA232183 Hs.173042 ESTs; Weakly similar to III! ALU SUBFAMILY J 2.9

104685 AA010530 Hs.9599 Human BAC clone GS025M02 from 7q21-q22 2.9

108677 AA115629 Hs.118531 ESTs 2.9

116028 AA452112 Hs.42644 thioredoxin-like 2.9

105404 AA243303 Hs.21187 ESTs 2.9

132365 AA598694 Hs.46541 Homo sapiens PAC clone DJ0894A10 from 7q32-q3 2.9

119638 W52480 Hs.56148 ESTs; Moderately similar to NY-REN-58 antigen 2.9

124637 N80716 Hs.75798 Human DNA sequence from clone 1183121 on chro 2.9

130588 AA287735 Hs.16411 Human DNA sequence from clone 1189B24 on chro 2.9

105640 AA281623 Hs.7525 ESTs; Weakly similar to KIAA0742 protein [H.s 2.9

131818 Z39297 Hs.3281 neuronal pentraxin II 2.9

119298 T23820 Hs.155478 cyclin T2 2.9

128742 D00763 Hs.251531 proteasome (prosome; macropain) subunit; alph 2.9

115089 AA255876 Hs.86919 ESTs; Weakly similar to HI! ALU SUBFAMILY J 2.9 100468 D89289 Hs 118722 fucosyltransferase 8 (alpha (1,6) fucosyltran 28

132920 L06133 Hs 606 ATPase, Cu++ transporting, alpha polypeptide 28

113490 T88700 Hs 173374 ESTs 28

133451 Y00764 Hs 73818 ubiquiπol-cytochrome c reductase hinge protei 28

128770 H98645 Hs 143460 protein kinase C, nu 28

129122 N62515 Hs 108790 ESTs 28

104827 AA035630 Hs 8551 PRP4/STK/WD splicing factor 28

111348 N90041 Hs 9585 ESTs 28

130987 R45698 Hs 21893 ESTs, Weakly similar to cAMP inducible 2 prat 28

102139 U15932 Hs 2128 dual specificity phosphatase 5 28

114902 AA236359 Hs 39504 ESTs 28

106094 AA419461 Hs 18127 ESTs 28

126438 N93125 Hs 137300 ESTs 28

107129 AA620553 Hs 4756 flap structure-specific endonuclease 1 28

104491 N71513 Hs 39328 ESTs 28

105043 AA132239 Hs 11810 ESTs, Weakly similar to CD42 [C elegans] 28

106855 AA486182 Hs 17975 ESTs 28

109695 F09530 Hs 180591 ESTs, Weakly similar to R06F65b [C elegans] 28

120455 AA251083 Hs 104347 ESTs 28

130861 N23393 Hs 20509 ESTs 28

131649 AA481254 Hs 30120 ESTs 28

128517 AA280617 Hs 100861 ESTs, Weakly similar to p60 katanin [H sapien 28

100486 HG1112-HT1112 Ras-ϋke Protein Tc4 28

116729 F13700 Hs 115823 πbonuclease P, 40kD subunit 28

101851 M94250 Hs 82045 midkine (neuπte growth-promoting factor 2) 28

115465 AA286941 Hs 43691 ESTs 28

100137 D13627 Hs 15071 chaperonin containing TCP1, subunit 8 (theta) 28

125837 H05323 Hs 146401 endothelial monocyte-activating polypeptide 28

131562 U90551 Hs 28777 H2A histoπe family, member L 28

129445 AA306121 Hs 111515 ESTs, Weakly similar to predicted using Genef 28

129239 D31544 Hs 109701 ESTs, Moderately similar to weak similarity t 28

106507 AA452584 Hs 91585 protein phosphatase 1, regulatory (inhibitor) 28

101664 M60752 Hs 121017 H2A histone family, member A 28

129426 AA412087 Hs 168272 EST, Highly similar to protein inhibitor of a 28

103437 X98260 Hs 82254 M phase phosphoproteiπ 11 28

129821 F11019 Hs 12696 cortactin SH3 domain-binding protein 28

130160 Z39228 Hs 151344 UDP-Gal betaGlcNAc beta 1 ,3-galactosyltransfe 28

104257 AF006265 Hs 9222 estrogen receptor-binding fragment associated 28

116204 AA465701 Hs 108646 ESTs 28

125914 AA262925 Hs 180034 cleavage stimulation factor, 3' pre-RNA, subu 28

131510 AA207114 Hs 27842 ESTs, Weakly similar to similar to 1-acyl-gly 28

106291 AA435551 Hs 30824 ESTs 28

122761 AA459296 Hs 105039 ESTs, Weakly similar to «" ALU SUBFAMILY J 28

107056 AA600310 Hs 18720 programmed cell death 8 (apoptosis-inducmg f 28

108535 AA084505 Hs 226440 Homo sapiens clone 24881 mRNA sequence 28

116226 AA478729 Hs 76450 ESTs 28

120266 AA173939 Hs 193902 ESTs, Weakly similar to inner centromere prat 28

128654 H20689 Hs 103180 actin like 6 28

116726 F13681 Hs 42309 ESTs 27

132640 U33821 Taxi (human T-cell leukemia virus type I) bin 27

133273 AA147725 Hs 69469 dendπtic cell protein 27

108846 AA132983 Hs 44155 DKFZP586G1517 protein 27

105621 AA280865 Hs 6375 Homo sapiens mRNA, cDNA DKFZp564K0222 (from c 27

129164 AA282183 Hs 109045 ESTs 27

133618 U78524 Hs 75251 DEAD/H (Asp-Glu Ala Asp/His) box binding prat 27

120521 AA258785 Hs 107476 ATP synthase, H+ transporting, mitochondπal 27

116429 AA609710 Hs 82837 Human chromosome 3p21 1 gene sequence 27

110984 N52006 Hs 80120 UDP-N-acetyl-alpha-D-galactosamine polypeptid 27

100372 D79997 Hs 184339 KIAA0175 gene product 27

125134 W19228 Hs 100748 ESTs 27

129254 AA453624 Hs 1098 deoxynucleotidyltransferase, terminal 27

102339 U37022 Hs 95577 cyclm-dependent kinase 4 27

106589 AA456646 Hs 28661 ESTs 27

119118 R44122 Hs 42743 ESTs, Weakly similar to predicted using Genef 27

105973 AA406320 Hs 21201 DKFZP566B0846 protein 27

106317 AA436568 Hs 172140 ESTs 27

115551 AA365527 Hs 177861 ESTs, Highly similar to CGI-110 protein [H sa 27

103789 AA096178 Hs 70337 immunoglobulin superfamily, member 4 27

105079 AA143190 Hs 12677 ESTs, Highly similar to CGI-147 protein [H sa 27

109299 AA205649 Hs 86371 zinc finger protein 254 27

122089 AA432136 Hs 98682 ESTs 27

129108 L20321 Hs 1087 seπne/threonine kinase 2 27

129385 D82675 Hs 110950 Homo sapiens clone 25007 mRNA sequence 27

131412 U34044 Hs 124027 SELENOPHOSPHATE SYNTHETASE , Human selenium d 27

104052 AA393164 Hs 97644 mammaglobin 2 27

116254 AA481146 Hs 41086 ESTs, Weakly similar to OXYSTEROL-BINDING PRO 27

106878 AA488872 Hs 12314 Homo sapiens mRNA, cDNA DKFZp586C1019 (fromc 27

114652 AA101416 Hs 107149 ESTs, Weakly similar to PTB-ASSOCIATED SPLICI 27

106831 AA482014 Hs 29463 centπn, EF-hand protein, 3 (CDC31 yeast homo 27

101445 M21259 Hs 1066 small nuclear nbonucleoprotein polypeptide E 27

124428 N36881 Hs 82202 πbosomal protein L17 27

114471 AA028074 Hs 103387 ESTs 27

102051 U07550 Hs 1197 heat shock 10kD protein 1 (chaperonin 10) 27

106916 AA490814 Hs 24170 ESTs, Weakly similar to πbosomal S1 protein 27 116142 AA460649 Hs.39457 ESTs 2.7

109912 H05509 Hs.24639 ESTs 2.7

103193 X70476 Hs.75724 coatomer protein complex; subunit beta 2 (bet 2.7

102046 U07151 Hs.182215 ADP-ribosylatioπ factor-like 3 2.7

104567 R64534 Hs.101469 ESTs 2.7

112996 T23539 Hs.7165 zinc finger protein 259 2.7

118138 N57773 Hs.93560 ESTs; Weakly similarto frg [R.norvegicus] 2.7

123095 AA485724 Hs.192119 ESTs 2.7

124315 H94892 Hs.6906 v-ral simian leukemia viral oncogene homolog 2.7

124447 N48000 Hs.140945 Homo sapiens mRNA; cDNA DKFZp586L141 (from cl 2.7

132834 H77546 Hs.57898 ESTs; Highly similar to NY-REN49 antigen [H. 2.7

107529 Y12065 Hs.5092 nucleolar protein (KKE/D repeat) 2.7

130648 AA075427 Hs.17296 ESTs; Weakly similarto /prediction 2.7

106685 AA461551 Hs.16251 ESTs; Highly similar to 73 kDA subunit of de 2.6

133848 AA093287 Hs.76728 ESTs 2.6

134880 AA092376 Hs.90606 15 kDaselenoprotein 2.6

128871 AA400271 Hs.106778 Homo sapiens mRNA for putative Ca2+-transport 2.6

106846 AA485223 Hs.34892 ESTs 2.6

119892 W84548 Hs.94896 ESTs 2.6

132309 AA460917 Hs.2780 jun D proto-oncogene 2.6

132923 U21858 Hs.60679 TATA box binding protein (TBP)-associated fac 2.6

114365 Z41688 Hs.18653 ESTs 2.6

114162 Z38909 Hs.22265 ESTs 2.6

133370 AA156897 Hs.72157 DKFZP564I1922 protein 2.6

106818 AA480890 Hs.3542 ESTs ^ 2.6

133501 W16684 Hs.74284 ESTs; Moderately similar to Similar to S.cere 2.6

100530 HG1869-HT1904 Male Enhanced Antigen 2.6

130553 AA430032 Hs.252587 pituitary tumor-transforming 1 2.6

108917 AA137078 Hs.173648 ESTs 2.6

122249 AA436679 Hs.258543 ESTs; Highly similar to CGI-07 protein [H.sap 2.6

119598 W45531 Hs.94642 ESTs 2.6

119802 W84865 Hs.40094 Human DNA sequence from clone 167A19 on chrom 2.6

133272 AA465016 Hs.69423 kallikrein 10 2.6

132575 AA045365 Hs.5188 ESTs; Weakly similar to 60S RIBOSOMAL PROTEIN 2.6

130459 AA460264 Hs.155983 KIAA0677 gene product 2.6

133083 N70633 Hs.6456 chaperonin containing TCP1 ; subunit 2 (beta) 2.6

131130 T19399 Hs.23255 nucieoporin 155kD 2.6

112043 R43317 Hs.26312 glioma amplified on chromosome 1 protein (leu 2.6

116146 AA460701 Hs.193200 ESTs 2.6

122378 AA446100 Hs.103617 ESTs 2.6

103134 X65724 Hs.2839 Norrie disease (pseudoglioma) 2.6

133395 AA491296 Hs.72805 ESTs 2.6

115652 AA405098 Hs.38178 ESTs 2.6

104975 AA086071 Hs.50758 chromosome-associated polypeptide C 2.6

134691 M59979 Hs.88474 prostaglandin-endoperaxide synthase 1 (prosta 2.6

112869 T03313 Hs.4747 dyskeratosis coπgenita 1; dyskerin 2.6

100092 AF000231 Hs.75618 RAB11 A; member RAS oncogene family 2.6

102635 U66838 Hs.79378 cyclin A1 2.6

104490 N71503 Hs.43087 ESTs; Weakly similarto dysferlin [H.sapiens] 2.6

106813 AA479922 Hs.181022 ESTs 2.6

106872 AA487907 Hs.18282 ESTs; Highly similar to unknown [H.sapiens] 2.6

107022 AA599041 Hs.28866 programmed cell death 10 2.6

107113 AA610073 Hs.23900 ESTs; Weakly similar to oligophrenin-1 like p 2.6

113281 T66300 Hs.112356 Homo sapiens mRNA for lipoyltraπsferase; comp 2.6

115586 AA399218 Hs.92423 ESTs 2.6

115779 AA424183 Hs.70945 ESTs 2.6

122895 AA469946 Hs.105325 ESTs 2.6

124726 R15740 Hs.104576 carbohydrate (keratan sulfate Gal-6) sulfotra 2.6

129775 R94659 Hs.12420 ESTs 2.6

131991 AA251909 Hs.36708 budding uninhibited by benzimidazoles 1 (yeas 2.6

132518 D57975 Hs.5064 ESTs 2.6

134612 AA451712 Hs.171581 ESTs; Highly similar to ubiquitin C-terminal 2.6

130313 AA620323 Hs.154320 ubiquitin-activating enzyme E1C (homologous t 2.6

131971 R70167 Hs.3611 ESTs 2.6

133175 AA134767 Hs.66666 ESTs 2.6

102083 U10323 Hs.75117 interleukin enhancer binding factor 2; 45kD 2.6

125670 AI432621 Hs.82685 CD47 antigen (Rh-related antigen; integrin-as 2.6

121822 AA425107 Hs.97016 ESTs; Moderately similar to SH3 domain-bindin 2.6

106719 AA465171 Hs.236844 ESTs 2.6

130029 AA236412 Hs.236510 ESTs; Moderately similar to PFT27 [M.musculus 2.6

124328 H97781 Hs.14415 ESTs; Highly similar to CGI-108 protein (H.sa 2.6

105387 AA236951 Hs.108636 chromosome 1 open reading frame 9 2.6

103073 X59417 Hs.74077 proteasome (prosome; macropain) subunit; alph 2.6

116294 AA489000 Hs.93748 ESTs; Moderately similar to TRANSCRIPTION FAC 2.6

135339 D59269 Hs.127842 Homo sapiens mRNA full length insert cDNA clo 2.6

125390 H95094 Hs.75187 franslocase of outer mitochondrial membrane 2 2.6

102504 U52077 Hs.247948 Human marinerl transposase gene; complete con 2.6

131076 H44386 Hs.22666 ESTs 2.6

114096 Z38342 Hs.27007 chromosome condensation 1-like 2.6

120402 AA234339 Hs.50282 GTP-binding protein ragB 2.6

102125 U14550 Hs.107573 sialyltransferase 2.6

134653 AA452818 Hs.87385 ESTs 2.6

101959 S80343 Hs.180832 argiπyl-tRNA synthetase 2.6

116766 H13260 Hs.95097 ESTs 2.6 104954 AA074514 Hs 26213 E ESTs, Weakly similar to protein [H sapiens] 25

108771 AA127924 Hs 71034 f ESTs 25

116439 AA610068 Hs 43913 f PIBF1 gene product 25

133859 U86782 Hs 178761 5 26S proteasome associated padl homolog 25

132792 AA401903 Hs 242985 r hemoglobin, gamma G 2.5

129620 AA010686 Hs 239720 t ESTs, Weakly similar to KIAA0691 protein [H s 25

120296 AA191353 Hs 22385 t ESTs, Weakly similar to KIAA0970 protein [H s 25

115615 AA401186 Hs 48617 t ESTs 25

102983 X17620 Hs 118638 r non metastatic cells 1, protein (NM23A) expre 25

106288 AA435536 Hs 24336 t ESTs 25

107444 W28391 Hs5181 [ proliferation associated 2G4, 38kD 25

104525 R16007 Hs 75355 i ubiquitin-conjugating enzyme E2N (homologous 25

128917 AA204876 Hs 206097 c oncogene TC21 25

102299 U32907 Hs 155545 c 37 kDa leucine πch repeat (LRR) protein 25

115363 AA282071 Hs 152759 ; activator of S phase kinase 25

130399 AA449417 Hs 155356 1 Homo sapiens mRNA for putative glucosyltransf 25

130752 D50927 Hs 18895 ttousled-like kinase 1 25

132724 AA417962 Hs 55498 c geranylgeranyl diphosphate synthase 1 25

106743 AA476352 Hs 21938 i ESTs, Weakly similar to KIAA0704 protein [H s 25

128949 AA190993 Hs 8850 ; a dismtegπn and metalloprotemase domain 12 25

125685 AI040346 Hs4943 t hepatocellular carcinoma associated protein, 25

105826 AA398243 Hs 21806 i ESTs, Moderately similar to similar to NEDD-4 25

110841 N31610 Hs 18645 1 ESTs, Weakly similar to partial CDS [C elegan 25

111987 R42Q36 Hs 6763 1 KIAA0942 protein 25

132669 AA188378 Hs 54602 1 ESTs, Weajdy similar to 60S RIBOSOMAL PROTEIN 25

100398 D84557 Hs 155462 I minichromosome maintenance deficient (mιs5, S 25

130800 AA223366 Hs 19574 I ESTs, Weakly similar to katanm p80 subunit [ 25

114481 AA033562 Hs 151572 1 ESTs 25

113404 T82323 Hs70337 iimmunoglobulin superfamily; member 4 25

100260 D38491 Hs 174135 1 KIAA0117 protein 25

103563 Z22534 Hs 150402 i activin A receptor, type I 25

104573 R68952 Hs 29780 1 ESTs 25

105025 AA126336 Hs 22744 1 ESTs, Weakly similar to ZINC FINGER PROTEIN 1 2 5

105524 AA258158 Hs 22153 1 ESTs Weakly similar to KIAA0352 [H sapiensl 25

106157 AA425367 Hs 32094 1 ESTs 25

107243 D59489 Hs 34727 1 ESTs 25

109920 H05733 Hs 30558 1 ESTs 25

109981 H09552 Hs 26090 1 ESTs, Weakly similar to T20B12 1 [C elegans] 25

114518 AA046407 Hs 106469 ! suppressor of varl (S cerevisiae) 3-lιke 1 25

114768 AA149007 Hs 182339 I Ets homologous factor 25

118906 N91000 Hs 94433 I ESTs 25

119025 N98926 Hs 55209 I ESTs, Weakly similar to DMR-N9 PROTEIN [H sap 25

131712 N29502 Hs 30991 I KIAA0957 protein 25

132233 X04706 Hs 93574 I homeo box D3 25

132740 AA227751 Hs 55896 I ESTs 25

115239 AA278650 Hs 73291 I ESTs, Weakly similar to similar to the beta t 25

128820 F10338 Hs 106309 I Fπeπd of GATA2 25

124049 F10523 Hs74519 | pπmase, polypeptide 2A (58kD) 25

128781 X85372 Hs 105465 ! small nuclear πbonucleoprotein polypeptide F 25

121361 AA405494 Hs 183052 I ESTs 25

134133 X93920 Hs 180383 i dual specificity phosphatase 6 25

102502 U51678 Hs 78050 ! small acidic protein 25

115875 AA433943 Hs43946 1 ESTs, Weakly similar to Weak similaπty to Ye 25

132874 AA425776 Hs 58609 1 ESTs 25

109646 F04543 Hs5028 1 DKFZP564O0423 protein 25

111197 N68093 Hs 22909 1 ESTs 25

102968 X16396 Hs 154672 i methylene tetrahydrofolate dehydrogenase (NAD 25

124911 R88992 Hs 123645 ESTs 25

106628 AA459657 Hs 12311 I Homo sapiens clone 23570 mRNA sequence 25

116988 H82527 ys69e12 s1 Soares retina N2b4HR Homo sapiens 25

131075 Y00757 Hs 2265 i secretory granule, neuroendocnne protein 1 ( 25

133578 X78627 Hs 75066 I translin 25

100420 D86983 Hs 118893 | p53-responsιve gene 2 25

130743 W87710 Hs 18724 Homo sapiens mRNA, cDNA DKFZp564F093 (from cl 25

122465 AA448164 Hs 99153 ESTs, Highly similar to CGI 73 protein [H sap 25

115117 AA256492 Hs49007 poly(A) polymerase 25

124582 N68477 Hs 108408 ESTs, Highly similar to CGI-78 protein [H sap 25

104771 AA025911 Hs 24994 ESTs, Highly similar to CGI-53 protein [H sap 25

108059 AA043944 Hs 62663 ESTs 25

105628 AA281251 Hs 35696 ESTs, Weakly similar to putative zinc finger 25

109261 AA195255 Hs 61779 ESTs 25

119789 W73140 Hs50915 kallikrein 5 25

130512 AA045304 Hs 181271 ESTs, Highly similar to CGI-120 protein [H sa 25

134402 U25165 Hs 82712 fragile X mental retardation, autosomal homol 25

104769 AA025887 Hs 114774 ESTs, Weakly similar to «« ALU SUBFAMILY J 25

125787 AA744748 Hs 29403 ESTs, Weakly similar to PROBABLE ATP-DEPENDEN 25

131775 AA459555 Hs 31921 KIAA0648 protein 25

TABLE7E I

Pkey Unique Eos probesetidentifiernumber

CAT number Geneclusternumber

Accessiori Genbankaccession numbers Pkey CAT Number Accession

101335 46413.1 L49054 N87447 AA248791 AA452193 AI015525 AI762070 AA781526 AW183498 AA625682 AI268713 AA400391 A1193725 AW590304 W56360 AA936067 AI990398 AA406183 AA628888 AA844206 AA621117 AI141092 AI808150 BE379750 AI351482 AAΘ93527 AA405119 AA400562 AW368723 AA463811 AW242927 R50034 W56334 F21257 AA164314 BE074125 AA470924 AI307439 W16738 AA026647 T35999 T19178 AA164313 AI744010 AI015466 AI014921

100906 4312.1 AU076916 BE298110 AW239395 AW672700 NM.003875 U10860 AW651755 BE297958 C03806 AI795876 AA644165 T36030 AW392852 AA446421 AW881866 AI469428 BE548103 T96204 R94457 N78225 AI564549 AW004984 AW780423 AW675448 AW087890 AA971454 AA305698 AA879433 AA535069 AI394371 AA928053 AI378367 N59764 AI364000 AI431285 T81090 AW674657 AW674987 AA897396 AW673412 BE063175 AW674408 AI202011 R00723 AI753769 AI460161 AW079585 AW275744 AI873729 D25791 BE537646 T81139 R00722

102221 3861.1 NM.006769 U24576 AW161961 AW160473 AW160465 AW160472 AW161069 AI824831 AW162635 AI990356 AW162477 AW162571 AI520836 AW162352 AW162351 AW162752 AI962216 AI537346 AA853902 H17667 BE045346 BE559802 BE255391 AA985217 AA235051 AI129757 AW366451 T34489 D56106 D56351 AI936579 AW023219 AW889335AW889120AW889232 AW889175 BE093702AW889349 AA147546 AI952998 AA912579 AI143356 AW902211 R64717 AW157236 AI815242 D45274 AW263991 AA442920 AA129965 AL035713 AI923255 A1949082 AI142826 A1684160 AI701987 AI678954 AI827349 BE463635 AW628092 AW302281 AA493203 BE348856 BE536419 AW193969 AW673561 AW592609 AI224044 H43943 AA091912 R49632 R48353 AI568409 R48256 AI198046 H27986 H43899 AI678759 AI680310 AI624220 H17052 AA156410 N56062 AI699430 AA664529 T09406 T10459 AA627506 AI379584 N83831 N88633 AW022651 AA971281 AA248036 AI039197 AI914689 AA973825 AL047305 AA129966 AI798369 AW264348 AI445879 AI658759 N67924 AI933507 AI216121 AI333174 T10972 AI375028 AI186756 AI273778 AA610487 AI797946 AA853903 AA903939 AI338587 AI278494 AW627595 AA904019

101714 30725.1 M68874 AL022147 M72393 AL049797 BE439441 T27650 AI766240 AW150345 AW778943 AI627464 BE439479 AA587049 AI277900 AI984983AI630935

116803 55078.4 H47357 W33034 H55976 H55975 R67830 AA527091 F24482 AW841585 R66514 116988 185904.1 AW953679 AW953680 AA244436 H82527 AA361046 AA244483 H82526 132640 179 1 AW162087 AA224538 AA471218 AA088655 AA375275 BE440052 AF090891 AA324435 AF063549 All 10675 AA322223 AW953306 AA233590 AW949864 AW949859 AA383721 AA081878 U33821 NM.006024 AA350900 AA081588 AI148087 AF268075 AA088185 AI142478 AA081824 AI887930 AA070570 BE185248 AI459825 BE257794 AA420459 AA420859 AA777997 AA081219 AW815721 AW854758 AA157932 BE018208 AW378974 AL041212 AI247564 AW581897 AI002897 BE543242 AI811690 AW852076 AW852270 AA360969 AA094943AA090680 AW601554AA099673AA662226 AA356814 AA330174AA187544 C02751 AA315460 BE168358 AW080447 AI813764 AI624222 AW156901 AI954032 AW473780 AI861975 AA173643 AW511541 AI951492 BE301686 AA669760 BE182212 AA081009 T69431 Al 186207 AA604124 AA707346 AA173953 AI016700 AI125916 AA358962 AI673719 T90593 T90497T10776 AW513002AW304292AA724885 AW474759 AI811621 AW068925 AA666305 AI580161 AI128023 AW471151 AA534849 AA666358 AI078833 AI139223 AI244874 Ai381658 AW263441 A1432440 AW802882 N66401 AA224251 AI167469 AH 41060 AA099214 AI537130 AL120428 AA948655 D53110 AA076099 AA938617 AA826543 AI357914 AA565098 AA807994 AI288812 AA632832 AA157933 AA639802 AA634268 AA282337 AA551431 AA557374 AA256923 AA872943 AA009665 H89626 AA810386 T92925 T36145 AA632190 AA130436 AI686635 AA130437 AW392904 AW392839 AW392848 AW392836 AA729737 AA070450 AW392890 W04825 AA771848 AA084634 AA481985 AI263840 AI801006 AA235380 AI954229 AI559330 AI208724 AA887638 T25894 AA041269 W44443 AI581770 W46171 AA878485 W46535 AA197336 AA894945 AA394224 AI766834 AI582590 AI033007 AA481889 AW190598 AW392855 R27279 AA398137 AI248407 AI241386 AI991753 AI826585 AA865699 AI096806 AI833030 AA041279 AW888745 AI703279 N70572 AI912553 BE549931 AI240422 AW376187 AW591692 AA975905 AW614967 AA009666 W44332 AA664659 T06561 BE468150 AI650695 AA587920 AI473310 A1032991 AA256499 AW104241 BE163782 A1984973 BE163613 AI263906AA628191 AA282072 BE163769 BE163775 AI492939 AI473315 D56907 AA587930 H89480 AI362373 AA598483 D56595 Al 167590 C16223 AI935415 D62555 D62884 D63130 AI760286 AI650286 AW173598 AI499145 AI122566 AW903408 AI810569 AA854936 BE049510 D62065 D61900 D62101 R27475 AI469835 A1669086 N80399 N48922 N48746 AA481381 R22858 H13912 AC004549 AW602500 AW768788

103427 43892.1 BE514383 AA071273 AW247987 AW673286 BE312102 AW749824 BE071985 AW577383 BE071945 BE072005 AW577355 BE071965 AW239231 BE072000 BE071960 AW577360 AW749830 AW373020 X97303 AW999522 BE000192 BE562219 BE266655 BE264970 103631 152.34 R64730 AF214731 T19173 BE258318 AF161446 BE542228 BE383856 BE206748 BE543260 AA640735 AA788907 BE251313 BE221852 AW855357 AA224407 AW855346 BE150454 AW070651 BE326867 AW051698 AI829278 AI470927 AW855345 AI804942 AI971004 BE046620 AI863664 AA808492 AI915971 BE046949 AW590711 AI468066 BE409685 AA332653 BE385394 AA852623 BE255591 BE254968 AA211871 BE255493 BE257727 BE255389 BE257491 BE262528 BE261296 BE313277 BE261714 BE314316 Z28434 AA315545 BE008562 BE012093 BE161393 T31969 AA305848 AW955238 BE619156 AI191748 AA323396 AW361760 AA216118 BE264939 AA325954 AW580281 AA302597 AW888908 AW888893 BE312970 AA134402 H52679 AA478191 T34090 AW961505 Z24771 AA179552 R57244 BE315207 AW583121 AI372747 T33143 AW377460 T33141 R14922 AW352414 H93249 AW405576 T33102 R89545 N46625 H08434 BE165062 AW367891 H93121 H47325 T30931 AW402852 H47410 Z20368 T18928 T30758 H93254 AW389725 R96628 AI372407 R88995 AI815980 AW157278 AW607664 AW163288 AA133492 AA099328 AA157348 AI816063 AW449556 AA157252 AW608980 H66576 AW821127 T32030 AW856058 AA032188 Z42120 R18582 AW402392 BE408021 AA280989 AA039427 AA035354 AW328008 T94186 R97481 AA181444 AA774697 BE613141 AW630221 H13066 AI124578 AW754481 BE262112 AW839942 H60108 AW364002 AW363800 BE547161 BE082634 AA642471 BE619719 BE082719 W28879 AW794944 C01685 AI291127 AW166099 AI936102 AI478929 R70284 AA872914 W31065 N54216 AI568741 H56262 NM 017425 Z48570 AI831777 T75007 AA354867 AA427988 AI922844 AA733170 AW821145 BE081547 AW881571 AW881573 AW055249 AA204724 A1417415 AI127303 AI355013 AI039527 AW593259 AA576745 AI457317 AW593236 H93126 BE396072 AL134941 AW629175 AI424011 AA115732 AA179986 AI334944 AW367922 AW152304 AA806752 A1312418 AW935023 BE301136 AA032258 AI829922 AI372406 BE177074 AW513743 AI151526 AA975643 AA478034 AI814920 AW080063 AI032624 BE177107 AA31976B AW935098 AI017620 AA974477 D51441 C14225 AL043583 D80145 AI690771 AW009711 AW881570 AI220431 N51090AI143003AA961480AA039351 AI094885AI096520AA179553 AA593974AI373929AA677252AA687374 AA886867 AA312863 AI150654 AI138450 AA133209 H99368 AI565632 AW070496 AI539748 H59455 AI811537 H52680 T74907 AI499657 R96670 AA854796 AA427863 AA224345 AA889899 AI347782 AA931056 AI076059 AI360841 AI797975 AI362268 AI200968 BE350785 R97433 N98499 AA134403 AA035355 AW263162 AI369607 D80144 AI376627 AI520801 AA365942 AI707705 AI123495 T33101 H08716 AA804238 AA922201 AA723522 AW183592 AI445884 F34614 AW022342 AA363998 AA568793 AA152475 D31233 AA852622 AA099862 AI129147 AA922699 AA782664 T33142T30009 T32913 AI676138 AI914657 N34899 AI372746 AI265911 AI352444 AA443158 AA910603 AI420273 AA868050 AI277700 C14224 AW082087 R41447 Z38385 AI911845 AI961888 R91976 F04560 AA661955 AI857675 AA369666 AA424207 N79953 AA382958 AA894626 AI884964 AA846989 AA215454 AI742580 AI339437 AI806879 AI091373 AA782558 AI026868 AW590904 AW204599 BE348235 AI819318 AA122324 AA939221 AW139711 AA131608 AW613548 AA122286 AI309179 AA437247 AW339322 AI671306 AW439848 AA131701 AI078075 N64624AA812881 AI140547

129097 25953.1 BE243933 AA355449 T29766 F08396 N83324 NM 006963 S50223 AI207648 AA258092 AA113952 AI311718 AI128612 AW607449 M77172 AI951311 X52346 AA903307 AI569810 N55421 W77876 R37223 R83788 AA031666 H47092 AA133451 AA311095 AA906963 H87667 N56058 AA393593 W24864 H10710 F06925 F07239 AW386140 AA325018 AA235950 AW373176 N57158 AA258093 N39467 R21609 BE089979 R34173 AW889005 AA745644 AI693852 AA424914 AA744771 W72632 AI291213 AA524318 AI472134 AI911230 AA528418 AA115745 AA775720AI671134 AA975044AW298117AA321015 N26288 AW952194AI743379AI204233AI801026AA830690 AI146980 AW104611 AI338576 R21507 AI367623 BE244484 AI269308 AA031667 AI884346 AA731989 AA988943 AA235951 AA807887 AA642645 AI246489 N29739 AI216718 AI383349 AI038618 AI351476 AA806031 AI914178 H10711 AI095573 H89220 AW470854 AA729015 R83353 AA782239 R34295 H87165 AW419059 AI653689 Z40349 H89114 AW074506 AA397785 AA888377 AI911228 F03193 A1468783 AA702615 AI830829 AA748323 R37224 AA424915 AA731647 H47183

120695 9683.3 AA976503 AI917802 AA953664 AA404613 AA428771 BE280542 AW194691 AI927301 AI740458 AI796100 AI935603 AW052210 AA970201 AI633384 AA425910 AI017004 AI241295 AA402816 AA291468 100352 37786 1 AL133887 D64159 AF112218 AI766633 AL039303 AL133888 BE620604 AW976259 AW262792 AW591383 AI365413 N36652 AA807027

AI472041 BE620065

101084 13883 1 AW409934AW245855AU077157AW163245 AW161434AW250083 AA316055 BE621134AA171883 BE272494 L05425BE250310

NM.013285 BE311494 AA858436 AA308223 AW362598 AA373618 BE394454 AA126101 AA581348 AA303227 AA058438 AA126544 AL135350 AW996947 AA403201 AA446682 W79685 AW246249 AW577783 AW002316 AA320025 AW753913 AI798554 AW070650 BE250413 AW250835 BE076336 AI925558 AI907634 AW804193 AW804270 AA902387 AW804232 AW804255 AW607751 AI909114 AW157242 AA934590 AI628921 AI470650 AW409935 AW172793 AA401208 AW162279 AA888018 BE206452 AI826742 AA857353 AA483614 AA126418 AA722289 AA780182 AW768894 AW183614 AW156969 AI244063 AA863491 AI376281 AA582490 AA846248 AI474094 AW246802 AA446557 AA126000 AI699045 AI702310 AI253092 AA171554 AA831455 AW118384 AI954511 AI760439 AI867001 AA493881 W81287 AA515590 AA659297 AA635139 AA659293 AA766044 AA196109 N32569 AI907635

100502 26409.1 U15979 X17544 W52755 NM.003836 Z12172 AW370136 BE262564T49116 AA333753 BE262238 BE313737 H38153 AW583056 R28890

BE259532 D16897 AA885610 AA911293 AA319627 R94472 R29022 AA443405 R96397 W04904 W01746 W01204 N74203 N58621 AA701996 AW418723 N53220 AA602813 AA576129 AA593786 AA911577 AA575957 AI149135 AW573058 AA772985 AI188918 AI372065 AA575838 W60010 AI004576 AI131265 AA319845 T50070 A1335742 AA235245 W32706 AA447372 R96355 N59573 AA904616 AI291224 BE467454 T49117 AI268620 AA928248 AA449494 AA318817 T49929 R94473 H38154 AI076649 AW935307 AW605112 AW935433 AW935342 AW935310 AW935345 AI298308 AW935395 AW935384 AI184857 AA319871 T29465 C21134 Z19785 AA329107 T52079 AW935346 C06234 AI951555 T49928 AA371745 AA369296 AA346673 R82547 T50006

102398 entrez_U42359 U42359

Table 8A lists about 54 genes up regulated in ovanan cancer compared to normal adult tissues These were selected from 35403 probesets on the Affymetπx Eos Hu01 GeneChip array such that the ratio of "average" ovanan cancer to "average" normal adult tissues was greater than or equal to 40 The "average" ovanan cancer level was set to the 3rd highest amongst various ovanan cancers The "average" normal adult tissue level was set to the 4th highest amongst vaπous non malignant tissues In order to remove gene specific bxkgraund levels of non specific hybπdization the 15th percentile value amongst the non malignant tissues was subtrxted from both the numerator and the denominator before the ratio was evaluated

TABLE 8A ABOUT 54 UP REGULATED GENES OVARIAN CANCER VERSUS NORMAL ADULT TISSUES Pkey Pπmekey Ex Accn Exemplar Accession UG ID UniGene lD

Title UniGene Title ratio ration tumor vs normal tissues

Pkey Ex Accn UG ID Title ratio

130941 D49394 Hs 2142 5-hydroxytryptamιne (serotonin) receptor 3A 121

101249 L33881 Hs 1904 protein kinase C iota 11 8

132528 AA283006 Hs 50758 chromosome associated polypeptide C 11 5

102610 U65011 Hs 30743 preferentially expressed antigen in melanoma 11 0

115536 AA347193 Hs 62180 ESTs 100

129571 X51630 Hs 1145 Wilms tumor 1 93

105298 AA233459 Hs 26369 ESTs 78

121779 AA422036 Hs 98367 ESTs 73

104301 D45332 Hs 6783 ESTs 69

132191 AA449431 Hs 158688 KIAA0741 gene product 67

102136 U15552 Hs 85769 acidic 82 kDa protein mRNA 66

101804 M86699 Hs 169840 TTK protein kinase 65

132572 AA448297 Hs 237825 signal recognition particle 72kD 59

106738 AA470145 Hs 25130 ESTs 58

108857 AA133250 Hs 62180 ESTs 58

115291 AA279943 Hs 122579 ESTs 58

132632 N59764 Hs 5398 guanine monophosphate synthetase 58

116401 AA599963 Hs 59698 ESTs 57

132725 L41887 Hs 184167 splicing factor arginme/seπne πch 7 (35kD 57

129097 S50223 HKR-T1=Kruppel like zinc finger protein [huma 56

134520 N21407 Hs 257325 ESTs 55

108778 AA128548 Hs 90847 general transcπption fxtor IIIC polypeptid 54

131228 AA279157 Hs 24485 chondroitin sulfate proteoglycan 6 (bamacan) 52

116238 AA479362 Hs 47144 DKFZP586N0819 protein 52

108055 AA043562 Hs 62637 ESTs 51

132939 U76189 Hs 61152 exostoses (multiple) like 2 51

115909 AA436666 Hs 59761 ESTs 50

120438 AA243441 Hs 99488 ESTs Weakly similar to ORF YKR074w [S cerevi 50

123494 AA599786 Hs 112110 ESTs 50

109648 F04600 Hs 7154 ESTs 49

132624 AA164819 Hs 53631 ESTs 49

111234 N69287 Hs 21943 ESTs Weakly similar to ORF YGL221c [S cerevi 49

135242 M74093 Hs 9700 cyclin E1 49

123005 AA479726 Hs 105577 ESTs 48

116296 AA489033 Hs 62601 Homo sapiens mRNA cDNA DKFZp586K1318 (from c 47

100661 HG2874-HT3018 Ribosomal Protein L39 Homolog 46

111345 N89820 Hs 14559 ESTs 46

102627 U66561 Hs 158174 zinc finger protein 184 (Kruppel like) 45

106459 AA449741 Hs 4029 glioma-amplified sequence 41 45

102305 U33286 Hs 90073 chromosome segregation 1 (yeast homolog) like 45

129229 AA211941 Hs 109643 polyadenylate binding protein interxting pro 45

130376 R40873 Hs 155174 KIAA0432 gene product 44

120619 AA284372 Hs 111471 ESTs 44

122802 AA460530 Hs 256579 ESTs 44

116416 AA609219 Hs 39982 ESTs 43

115094 AA255921 Hs 88095 ESTs 42

126802 AA947601 Hs 97056 ESTs 42

126892 AI160190 Hs 76127 hect (homologous to the E6-AP (UBE3A) carboxy 42

105516 AA257971 Hs 21214 ESTs 41

131985 AA434329 Hs 36563 ESTs 41 114965 AA250737 Hs.72472 ESTs 4.0

120821 AA347419 Hs.96870 Homo sapiens mRNA full length insert cDNA clo 4.0

134621 L02547 Hs.172865 cleavage stimulation fxtoπ 3' pre-RNA; subu 4.0

134161 U97188 Hs.79440 IGF-II mRNA-binding protein 3 4.0

TABLE8B:

Pkey: Unique Eos probeset identifier number CAT number: Gene cluster number Accession: Genbank xcession numbers

Pkey CAT Number 101249 2520.1 L18964 NM.002740 L33881 AA095249 BE080871 AW605320 M85571 AA179776 AA160650 AW117327 BE467131 AW088338 AW937631

AW087514 AI480090 AI873147 T57875 AI217404 AA827196 AI279471 AA969093 AA815168 AA988896 AI754623 T28044 AW950302

AW950294 AI032193 AI953696 AI630583 AA062633 BE541355 AA180493 AW015748 AA255651

100661 23182 1 BE623001 L05096 AA383604 AW966416 N53295 AA460213 AW571519 AA603655 116401 95855.1 AW893940 AW978851 AA034240 AI686323 AI767653 AA829515 AA053933 AA737691 W92607 AW261869 AA835698 AA447216 AI623248

Z21891 AA835700AA599963 T20152 AA533167

116416 373989.1 AW753676 R11789 AW001886 AA609219 AW780420 AI860557 AI280331 AI33430Q AI288870 AA669343 N29918 BE537790 AA934687

H79075 N42970 R63752

132191 54683.4 AA507576 AI610269 AI380079 R40309 AI203932 AI342128 AI342578 R43110 AW583269 AI375234 AI092708 R52802 AI028462 AI016062

AI189144 AI016691 W45515 AA551452 AA449431 T10046 AA424059 N62822 AW197701 AA465242 A1418989 AI942433 AI891115 BE302316

AI743979 AI283341 AW340338 AA774643 AW104778 AI078020 N21487 H97562 AA970063 BE327945 F03880 F03885 AA970699 AI298468

AI380330 AI247787 AA770467 AI200154 AI089863 AI089890 AI695738 W88524 AI471010 AA700191 AA778937 BE440182 R79225 AA338236

AA548984 AA907692 N21250 AW904736 AI909337 AA987772 AW959228 AI149372 N29644 A1039967 AA677529 AI694291 R85811 N28672

AA465598 AA321185 AW130492 AI824479 AI682992

130941 2774.1 NM 00869 D49394 BE2^'δ2349 AW249320 AW249140 AW250535 S82612 AJ003079 AJ005205 AW178407 AA811360 AW976407 AW976408

AW248903 AA731733 AA804189 AA703169 AI435492 AI076288 AA912176 AW248713 AA743457 R08170 C06167 R02351

115909 47548.1 AW872527 AA453863 AA442475 AF086541 AA365801 AI692575 AW131631 AA732993 W96131 AA436666 AA453779 AA365504 AW959717

AA975337 AA365503 AI632902 AA659686 AA665087 C00396 AA988869

108778 18565.1 AF133123 NM.012086 AA128292 S81493 AL137453 BE614053 AA307628 8E009521 BE085659 BE085542 BE085598 AL120654 R13165

AA429306 R13465 R55236 AW994182 W00838 AW994417 AW994404 AW994426 AW994321 AA516147 AA345603 AW953009 BE315104

A1126654 AA626457 AA291327 H67983 H66271 H67976 AW270955 AA758221 AI023487 AI921811 AI953370 AF085850 R70992 N25129

AW295143 AI433661 AW608361 AA873402 AI217453 AI953358 AA262143 AA928495 AI475268 AI167211 AW385961 AA259045 AI762630

AA428238 AI001932 A1735550 A1951370 AA766807 S81492 AA918976 AI040967 R7Q939 AA469065 T7034Q AA477615 AA47807Q AI017743

AI608833 AI635824AI186039AA741312 AI040184 H67656AA258221 AA731316 AI381293 AW298473 R55237 R37375 AI768014 AA128548

AI206773 A1879827 R64193

102136 17647.1 AA300576 U15552 NM.014597 AA223318 AA171806 BE269461 AW578439 AW604388 AW953513 AA772816 AW604383 AW577851

BE169672 AW117711 AW366303 AW366302 AW366308 AW366304 AW366300 AI908432 AW591937 AI358420 AW272622 C75067 AI926471

AW002266 BE064947 BE064722 T10372 AW838681 AI811119 AW262098 AA588547 AI916666 AI440083 A1078150 F24260 AA512919

AI953413 AI064798 AI420425 AA191324 BE503222 A1632721 AA180035 AA558329 W44843 T10610 W38442 BE542869 AI125024 BE279566

AW747936 AI589491 AA559096 AI090265 AA548959 AA223220 AW515936 AW368395 AW368407 BE540776 AI039762 AI584020 AA171691

108857 61.1 AK001468 AA190315 AA374980 AW961179 AA307782 AA315295 AA347194 AW953073 AW368190 AW368192 AA280772 AA251247 N85676

AI215522AI216389 N87835 R12261 57094AI660045M347193 R16712AW119006 N55905 N87768 AW900167 AI341261 AI818674 D202B5

A1475165 AA300756 R40626 AI122827 AA133250 AI952488 AA970372 AA889845 AW069517 AI524385 AA190314 AI673359 AA971105

AI351088 AI872789 AI919056 AI611216 AK001472 BE568761 AA581004

102305 18424 AL043202 U33286 NMJ01316 AF053641 AL048759 N99830 AA263091 AW408174 N90467 R84306 AA317882 BE613644 AA307378 T10722

AA207207 AA315560 AA113938 AW386317 AW386316 L44546 AW386335 AA243317 AA713588 AA192541 AA649035 BE300737 AW752491

AW902334 AW993922 BE003403 AA251521 AA382754 AA339152 AA382619 H58600 H67810 T70379 T82109 D81644 D60375 H59003

BE075732 AA471242 H17790 F11801 T84903 R78076 BE614356 R16380 R16395 AA876127 W95535 AA164768 AI279876 H02142 C18698

AA365866 AW954410 AI539769 T39128 AL121103 AA192466 AA213367 AI963800 BE090601 Z20096 8E566508 AI969470 BE044090 T65536

AA837311 AA075484 AA075621 AA778294 AA587266 T69722 AA446118 X85624 AI334209 AI587101 AI281280 AA568602 AA946837 C75603

AA236997 AA459274 AI150191 AA165156 AI198839 AA789258 AI139373 AA236574 AI127770 AA678954 AI140786 AA113939 AI187231

AI754062 AI753243 AA934719 AW439362 H02038 C17463 AI400951 AA227539 N66040 R89384 AA872668 AI344110 W95420 AA164700

C05669 BE094097 AI826398 H58956 T17222 AW139044 AI271344 T16445 R42323 C75565 AA165228 AI025443 AA165229 C21496 AI826239

A1868711 AA582354AA524392 R01549 R01641 Z21083 AA528463 T39127AA989472 F09450 AA084485 BE004378AW974353AA137250

AI278406 AW609291 AA137249 AA142866 AA639198 AW609271 AW149760 A1025112 AA236620 AA937248 U90736 AW005487 AW674427

BE397971 AW609285 T65602 T99684 T97378 AW609366 T85647 AI572235 T99083 AA199583 AW303874 T35523 AA586445 Z39669

AA459503 N95643 AW821210 AW813461 AW582064 AW609293 AW609320 AW609270 AW582085 AW582071 AW609318 AW813451

AW813456 AW582079 AW609276 AW609280 AW609290 AW582101 AW582102 AW609263 AW609317 AW609256 AW609305 AW5B2063

F06655 AW605343 AA446426 BE090595 AW969578 T79852 AI082505 N63239 AI973168 AI086182 AA846711 AI874213 AA730605 AI927257

AA912624 D60376 T10180 AA705847 AI018123 AA493197 T67083 R77739 AA953087 R00885 AI370606 R01642 AA862914 N57843

AW023353 H77483 H68082 R42337 H58601 97267

109648 708849.1 H17800 AI362549 AI671064 T23526 F03426 F04694 F04600 AI635856 Z38715 F02039 AW022635 132528 110278 T78736 AA284422AA283006 101804 26687.1 M86699 NM.003318 AL133475 AA122377 Z21415 R57092 AA806569 AA811904 BE538323 R41558 AA421620 AI337292 AA470077

AW795371 AA543024 AI677941 AI472200 AI215042 AA732384 AA837143 AA804229 AI907533 AI742701 AA121159 AI973225 AI620839

132572 31281.1 AI929659 AA227827 AF069765 AW408768 NM.006947 AF077019 AA220974 H07969 C14621 D52294 BE512960 BE614138 BE258539

BE251981 AA355433 AA481126 AW403053 BE542282 AI929818 AL120605 AW753079 AW391834 BE018603 BE395262 W21406 AW663259

AW975690 W93905 W96519 AI863832 AA443177 AA730942 T99558 T86581 W19444 N55583 AI701020 AI928986 AI857864 AI590849

AW081819 AA714970 AI122630 W04887 AW662427 AA602680 W93645 AA582946 AW008812 AA311187 AA463631 AI421918 AI400518

AI921404 AA143770 AA587675 BE302192 AA813080 A1493386 AW327435 AW340871 AI143616 AA687231 AA218961 AI362249 AI378345

N74716 AW969249 AA468581 AA516399 AI274726 AI131244 AI572604 AI929236 AW327971 R65637 N90309 H07877 W96486 AI358806

T90801 AI383246 AI740957 T86758 AI471248 AI864233 AA910590 AI079094 AW805781 AA709025 AW196707 AW327436 AI903790

AI873956 T99348 AI924643 AW103910 A1802993 AI080390 T99098 D19794 AW327972 A1935904 A1288575 AW360875 AA779784 N93574

AW769295 W32639 AA363094 N89012 W39751 AI291329 AI291371 AA829411 AI985219 AI422775 AA918940 AA363108 AA192633

AF086131 AA373679 AA165043 AA355705 AI243507 AI027796 AA573461 AA757260 AI370979 AA574149 AA558276 N70650 AI478948

R35393 AA448435 AA334659 AW879356 AA436527 AW972044 W25165 AA521219 AI094141 AI302096 AW578551 AW578534 AW390535

A1131472 N50381 AA736938 A1089112 AA863053 A1359793 AA962268T27353 D82590 AA448297 A1277168 AI368457 AA872737 AA330346

AA308346 AA342341 AA355159T85701 BE162893 T99703

131985 113870J AA503020 AI858190 AI686571 AW615203 AW073686 AW172459 AI828762 AW150534 AI859795 AA411046 AI539195 AA404609 AI638559

AA434329 AA171844 A1684143 AA953518 AW470108 A1870700 AA706376 AI539668 AI683712 AA075579 AI682137 AA291512 AA554431

H51315 AA404225 AA075632 AA172293 H51911 132624 42095.1 AA326108 W74020 AW612698 AI750909 AA487800 AJ270695 AA044941 H20708 AA296750 AA018401 AA378581 AW964159 AA018887

R68533 AA525338 AA526640 H84308 AA278942 AA164818 AA847110 T82335 N25519 AA021474 N31381 N36297 AA838191 AA318932 AA961206 N41430 N41439 AW630477 W37595 BE394538 AA365256 N47771 N34873 AA988105 AI242138 AW148523 AI978761 N50882 AA527448 AW086200 AI750910 N50868 AA709437 N51946 AI222179 AA732883 H96742 AW615360 N53720 W37490 R87362 AA613273 H98999 AI469022 AI368442 AI460122 N20486 N24087 AA164819 N24878 AW471270 AW590458 R68240 AA594434 N204J30 AI419626 AW500664 AI033658 AA593215 AA907408 AA713508 AI422627 H85551 AA923571 D62680 AW627456 H96206 AA016289 AA485896 N25691

132632 4312.1 AU076916 BE298110 AW239395 AW672700 NM 003875 U10860 AW651755 BE297958 C03806 AI795876 AA644165 T36030 AW392852 AA446421 AW881866 AI469428 BE548103 T96204 R94457 N78225 AI564549 AW004984 AW780423 AW675448 AW087890 AA971454 AA305698 AA879433 AA535069 AI394371 AA928053 A1378367 N59764 A1364000 AI431285 T81090 AW674657 AW674987 AA897396 AW673412 BE063175 AW674408 AI202011 R00723 AI753769 AI460161 AW079585 AW275744 AI873729 D25791 BE537646 T81139 R00722

102610 9336.1 U65011 NM.006115 AW182053 BE383930 BE407839 BE409930 BE408826 AW370292 AA312859 AA136204 AW365852 AW365735 BE622732 AW939295 AA781195 AI017284 AW375329 AW375366 AW178384 AW178333 AW178424 AW365726 AF025440 AW172852 AI570998 AW117792 AI885499 BE465516 BE207427 AW130942 AW513316 AW770892 BE207426 AW173563 AW168292 AW173565 AI810101 AI744983 AI861974 BE207404 A1744982 AI613210 AW591505 AW169285 AI521444 AI745044 AI627904 AI690634 AI289305 AA861253 AI612799 BE207425 AI149694 AA902662 AI082468 AI014752 AA613844 AA725693 AA136089 AI290092 AA565489 AI689083 AI859014AW051225AA665758 AA496991 AA564738T19428 AI567170 AW166726 AW084200 AW188723 AA617626 AI918664AW381473 AW381543 AA598817 AW088942 AW050423 AI362502 A1680308 AI687500 BE327836 D20455 BE410282 BE254766 BE256014 AA357423 BE618208 AA489577 AW182114 BE379147

102627 25245.1 AL021918AA160639 U66561 AA321623 U52098 AL119453AA455712 N80080 N46550 W07223 N75923 W05057AI811577AA455657 AI275409 AH39121 AI927568 AI927562 AI139471 AA160473 N78795 A1719983 AI718928 AA723097 AI335776 N39140 N59184 AI587600 AI864812 AA732097 N74667 AA832398 H89600 D19825 AI554833 132725 29101.1 NM_006276 NM.006276 L41887 L22253 BE379909 BE567870 BE274265 BE539518 AW239523 AW239271 AI093618 BE504485 AA580279 AA494481 BE440161 AW780428 BE543960 D55986 AA852399 AI630020 W77996 AA278193 R10505 AI963201 AI739336 BE174301 AA662222 AA664912 AA244152 AW611553 BE503285 AA211023 AA383016 AI698174 AW195381 AA948229 A1768495 AI690437 N30025 AI718952 AI953572 BE464509 AA777315 AI337221 AW070910 AI953848 AW674561 H54177 AW510890 AW078699 AI436178 AA630759 BE502074 AA278769 AI499038 AW469072 AA778071 AW236753 AI933033 AI690458 AI276691 AW768235 AI952118 AA425156 AA610579 W73953 AA244153 W86Q34 AI948872 AI952678 AW087811 AI333591 AI869883 AI926911 W48865 AL048024 AA214485 AI972522 AI151368 W48738 AA214467 AA334640 AI678170 AA927525 AA581588 W96283 AA365470 AI471919 AW61148B AA211834 AI365198 AI698365 AW002238 AA507624 W96150 AA446490 AL048025 AA852400 AA362221 A1338376 R35083 AA290812 R10397 AA975988 AW236462 Z43032 H16969 F13487 D19858 AA452207 BE085942 AA344396 AW949533 AA279472 AW902406 AW070440 BE395195 H00835 AA300750 AA729303 AA420591 AA385025 AA420542 R69155 AA420592 AA281747 N88502 AI458206 AI700996 AW418607 AW341202 AI825692 W00640 AA214405 AA044744 AI950617 BE467493 AW474113 AA446310 BE328705 AI911573 AW243968 AI628622 AW173020 AW079958 AI140387 A 051969 AW299438 A1127170 A 769164 A1422435 AI307116 BE549519 AI371116 AA281748 AA701073 AA679948 BE551197 N50345 AW338776 BE326601 AI142892 AW470687 AI989568 AA911241 AW294822 AI174414 AA804366 AI004725 AW271994 AI559313 AI270102 AI351542 AW768904 AA765964 AI961708 AI149231 AA995907 AI094280 AI185753 H01219 AW768846 AA747500 AA970106 AI601238AA513452 AW612802 BE075163 R39171 AI565328 AI375559 F10356 AA284625 BE241509 AI702889AW193010AA649847 AW439150 AA721407 AA810333 AA706384 AI049887 BE569015 BE622280 BE566618 AW967342 R69269

111234 83711.2 AA902656 AI185915 R43705 H15150 H09794 AA832464 AI697438 AI354538 AI436354 AA948272 AA928143 AI091263 R41658 AI352580 AI122948 AA946670 AI340088 AI275007 N70255 AA721176 AI934162 AA827098 AA935934 AA827088 AI081207 AA992399 AW130757 AI805667 AA035556 AI379266 AI093901 A1095234 AA909079 AA516079 AI572357 AA205969 A1432383 AA905290 AW628920 AW182996 AI266084 N49879AW024457AI246246 At934031 AI369270 AI003836 AA010063 AA494361 AI284151 A1919536 N34884N69287 AW510465 AI358609 AW081421 AA706205 AI085317 AI140633 AI347104 AA602547 AI686707 AA872686 AA694028 AI094546 Z40832 AI382838 AA610132 AA501433 H84120 AI140722 AW674839 BE503822 AW663895 BE327472 AW393494 AI340087 W04189 AW393499 H56506 BE089878 BE301950 AI025475 AA724446 BE275324 H15210 AW957667

134161 16074.1 AA634543 AI682259 AF117108 BE396917 NM.006547 U97188 U76705 BE560799 BE396918 BE269531 BE560268 BE560346 AA836048 AL023775 BE545535 AA427803 C18804 D58801 AA303353 U46218 BE539704 AA187966 AA252545 AA261821 D63197 AI824109 A1088047 A1424833 AI807368 AI250857 AA741476 AI146832 AA169615 AI809821 AI274288 AW136704 AI206172 AA917039 AA243584 AI808611 AW674709 AA935733 AW450092 AA905172 AA471196 AA302256 AW673348 AI352044 AW511295 AA247134 W81035 AA722962 AW662471 R64432 AW044616 AI086619 AW628546 AW043682 AA425750 AI743038 AI368723 AA187143 AI376987 AI803976 AI275537 AW471358 AW104877 AA195464 W81072 AW197351 AA932674 AI393420 AI434998 R63822 AW085083 AI240272 W87006 AA011347 H58428 AI497895 R23223

132939 11857.1 AB009284 AF000416 AA022636 BE082610 AW367997 AA491410 AA337477 AA336421 W38526 AA625283 AA773685 AA490078 T66134 AA847838 AA022647 AW054726 A1918001 AA431966 AI263596 AI804298 AW469314 U76189 AA779001 AA625945 AL042357 AI674730 AA410350 AK001450 AV654353 AA058443 D81618 AA853665 W31930 AA334445 AW955767 N47777 AA8B3784 AA428916 AI652062 AA329703 AI417923 AI435031 AA708791 AI989636 A1220345 AI239913 AI220102 AI435875 AI076731 AI377049AI039173 AW972638 N90076 AW263652 BE440048 BE440013 AA577463 AI038774 AW204992 AA846580 AA501952 AA342058 AA508525 D61670 W31725 AI689499 AI955969 AA526628 AI282717 T66198

111345 6692J AW263155 AA314512 AW408152 AA360413 BE206274 AK001402 AA307665 AW954678 W39078 AW369236 AW369115 AW369096 AW753235 AW369072 AW361194 AW369125 AW364187 H94225 T79502 AA131908 BE071359 AW368503 AW801517 AW801322 AI674163 AA861077 A1738568 AI830199 AW118577 AI478895 AI688497 H92996 AW083479 AW970625 AW613124 AI632234 AI654210 AI696847 AI923423 AA131909 AA806630 AA806158 AW592520 R96509 AA813923 AA502823 AW467889 AA960972 AA994566 AI280346 AA884588 AA653563 AI200023 N89820 AW768792 C00145 R96554 T79416

104301 145380.1 AA768491 AA476251 AA809748 A1186268 AA621244 A 79029 BE550341 AA651915 AI216376 AI215585 AI471780 AA772159 A 181980 AI151169 AA759270 AI675769 AI018776 AA757335 AA148511 AI138378 AA504167 AI420617 AW261930 AW872797 N51769 AW614403 AI860533 AW573108 N64830 A1693732 AI436159 BE501089 AI436163 AA971485 AI269364 AI935358 AI222050 AW303978 AW573247 AI871154 T16758 AI765893 AW969016 AA744720 BE094085 AA743769 AI476407 AA156619 AI768535 R81435 D45332 N75682 N51177 AW207406 AA425184 R20997 AA504168 Z43298

134520 13358.3 BE091005 BE541579 AW387738 AW386083 H13769 AW377820 AW369180 AW753239 AW672695 BE379572 AW021732 AW891450 AW891416 BE091358 N50375 BE091354 BE091365 BE091361 BE091363 BE091350 AA353863 AA845510 N21407 AW770981 AI361577 AA526557 AA525443 AW893622 AA630898 AI418983 BE172016 AA550754 AA664574 C16147 AA355902 AW958586 N51590 C20995 BE544186 AI337578 AA090549 AI807374 AW450654 BE067578 AA446781 AA447058 T10807 AA457082 AI267703 AI880220 BE568979 AW380506 BE150744 AW380468 AW380546 BE150713 D60029 H88099 BE546301 BE150731 AW368467 BE091348

135242 5782.1 AI583187 M73812AW339829 M74093 BE252510 BE252518 BE536901 U40788W95578 BE018493 BE544205 N83637 AI671049AW439693 AW300786 AW374970 AA592960 AI215885 A1215884 BE302101 AI186210 AW771831 T54213 AW452924 AA834019 W95471 AA628312 AW304866 AA570076 AI559873 T54121 134621 27351.1 AA037145 L02547 NM.001324AW411516 AA314711 AA143605 BE394455 AA325731 AA093227 AA083307 BE299438 BE295669 AA370886 AA338272 AA166862 BE304837 BE298306 R60507 AW238966 N72750 AW505406 AW994153 AA309742 AA309929 BE090721 AW904189 AW904214 AA363564 R94127 AA352101 R28249 AA206337 AW577208 AA385473 AA355463 AA400696 AA075587 W72815 AA554033 AA075530 AA620555 AA554034 T27804 AW950014 AI570740 AI268538 AA704423 AW411517 AI278646 AW339924 AI668917 AI796034 AA994601 R94082 AW027137 AA400652 AW299746 W72816 AA988494 AA146582 AW087489 AA992763 AW516454 AA992759 AW270444 AA227188 AI208929 AA167720 AI052527 AA865660 AA569368 AI888464 AI670003 AA827620 AA507543 AI888385 R88418 AW959083 AI341077 AI825719 BE552285 AA738076 AW085903 R28242

126802 116467.4 AW805510AW805503AW805500AW805819AW517040AW473670AW516701 T30141 AA894497BE349504AI272007AI985274BE501962 AW102975 AI801727 AW197918 T24046 AA947601 AW900958 126892 38252.1 AF121856 BE242657 U83194 AA226732 A1160190 AA948725 AI079958 AW513369 W39443 AW408479 W06854 AA094683 AI985095 AA316647 H96313 N78438 R81582 H95034 R79674 AA488552 W25292 W31697 W19918 T30640 R08686 H78637 AA165100 Z41909 ' AA165080 R34212 AA150886 T82168 N77082 W56864 R19848 AA888217 AA314539 AW750293 N62714 R58039 AA845453 N63268 W03474 N41923 AI264123 AI808533 AA824288 AW198143 N99916 AA902465 AA775397 AA772387 AI567675 AA227473 AI082614 R58334 N78878 R34329 AW438902 AA164685 AA558790 AI590102 AA863422 BE002625 AA934039 AI298102 W15351 H93997 AA725325BE180993 W05350 AI510771 W06941 AA488414 R79863 N91264 R76884 AA312948 T71267 AW959659 AI086695 N90421 AI278098 AA164538 AI300271 AA854381 R81331 AA700449 H06174 AW518427 AA876634 AA150778 N32393 H78585 T853648E002808 AW663196 N90337 BE252097 T71401 H06438 N40268 N31015 R77046 T99588 T85452 W25298T59815 H09416T85403 W32150 N79109 R78812

105298 8689.1 BE387790 BE276849 BE246825 BE246900 AA380487 AA332996 AW408727 AK000294 AI636887 AW197272 AW590657 AW594006 AI768979

AI751632 AA580098 AA313261 AA300475 AA133237 AA233499 BE242126 BE242597 BE242254 AA314374 AW961210 AW939345 AA173535 AA305779 R99373 AA128304 AA447246 AA476365 T34973 BE264878 N25149 Z24939 BE263038 AA128317 Z46082 H23504 AW378551 AA088533 AA442625 H15235 H79172 AA344697 AA344742 AL040280 BE173256 BE173129 T59749 AA088410 BE242311 AA173576 AA455337 AA129715 AA582953 AW612637 AA917038 AW340019 AW006315 AW593024 H05915 AW294592 AI146814 AW195659 AW440271 AI209090 AI288689 H98630 H15174 AI214454 AI569471 AA085808 AW188361 AI751631 AW440477 AW300860 AA516088 AI365108 AI305805 AI264064 AI246276 AA442611 AA807059 AA233459 AA875987 AI374653 AA972665 AA947515 AA436867 AI216423 AI657181 AI680306 AA436854 AI537153 AA883723 Z28659 AA705973 Z40741 AA463884 AI216025 AI564986 AA476316 AI432566 AI571662 AA447126 AW293675 AI675617 AW009004 H23498

120438 166102.1 AW015242 AA831493 AI292346 AI076966 AI191561 AA243441 AI183309 AA252613 AI038422 AI306531 AW051480 AI348605 AA195119

AI817119 AI091896 AA738440 AA195013 AA976687 AA459659 AI246250 BE219252 AI703457 AA243291 AA243401 AA989100 AA931640 AA459782

105516 9334.1 AK001269 AL354613 AA147472 AA490803 BE207628 AW816113 AA085574 AW503392 AA299910 AW750305 BE079539 BE079484

BE512838 AK001593 AW968772 AW967440 AW206280 AA251270 AI627886 AA303599 AA147473 BE206616 AA490611 AA715039 AW590866 AW590447 AI864512 AA204731 AA894490 BE001136 AA612785 AA237035 AA149960 Z44257 R12986 AA448446 AI734041 AA422167 BE220551 R66041 R32927 R32942 AA258773 AW386142 R53730 N54624 AW880296 AA253485 AW954441 H98989 AW614348 A1654838 AA779793 AW237213 N66635 AM86812 AA947479 BE158011 AI859480 AW805579 N52010 AA806305 AI628445 AW270990 AA778165 AA149949 A1650728 AA749108 AA687257 AI261661 AA747442 AA481351 AA206339 AA903407 AW473306 AI688930 AA262281 AA448310 AA748820 A1347430 BE465692 R32839 AW510564AA436408 AA257971 AA253362 AA938330 AA513150 AA976840 AA687117 AI281547AA046243 R32825 AI631554 AW139818 AI244536 R52946 AW235443 R40183 AA299909 AA811958 AI302918Z40213 BE158047 BE158060 AA767245 AW748159 AW500735 AA094074

129097 25953.1 BE243933 AA355449 T29766 F08396 N83324 NM 006963 S50223 AI207648 AA258092 AA113952 AI311718 AI128612 AW607449 M77172

AI951311 X52346 AA903307 AI569810 N55421 W77876 R37223 R83788 AA031666 H47092 AA133451 AA311095 AA906963 H87667 N56058 AA393593 W24864 H10710 F06925 F07239 AW386140 AA325018 AA235950 AW373176 N57158 AA258093 N39467 R21609 BE089979 R34173 AW889005 AA745644 A1693852 AA424914 AA744771 W72632 AI291213 AA524318 AI472134 AI911230 AA528418 AA115745 AA775720 AI671134 AA975044 AW298117 AA321015 N26288 AW952194 AI743379 AI204233 AI801026 AA830690 AI146980 AW104611 AI338576 R21507 AI367623 BE244484 AI269308 AA031667 AI884346 AA731989 AA988943 AA235951 AA807887 AA642645 AI246489 ' N29739 AI216718 AI383349 AI038618 AI351476 AAB06031 AI91417B H10711 AI095573 H89220 AW470854 AA729015 R83353 AA782239 R34295 H87165 AW419059 AI653689 Z40349 H89114 AW074506 AA397785 AA888377 AI911228 F03193 AI468783 AA702615 AI830829 AA748323 R37224 AA424915 AA731647 H47183

120619 169895.1 AW965339 AL045632 AA333229 AI806195 AA284372 AA206108 AA682533 AW449514 AA804785 AI215473 AI357263 AI651208 AI651753

129229 20927 1 AF013758 NM_006451 AI538709 AA209236 AA300293 AA367274 AA126598AA324825AW955225 F11436 AW374740AW374714AW374774

AW751514 W74780 AI909015 AW997079 AW997067 AW379344 AW363397 W38589 AA043823 BE169280 AI909016 AW994851 AI740638 AW148560 AW368339 AI858333 AA314718 AW954872 AW468734 AI681980 AW519045 AW055171 AA579286 AW069164 AW615004 AA345052 AI446735 AI142106 AA662683 AW002813 AI418280 AW613203 AI613333 AI354480 AI929755 AI146977 W74674 AW799610 AI798529 AI589422 AA043957 AI223043 AA157016 AI446759 D56729 AI587471 F30716 AA812125 AI537301 AA653347 D11966 AI434383 AA598533 AI287254AW139140 AW051033AA601911 AI702506 AA737460 T30221 AI129081 N90213 AA805225 AI798518 BE001071 T10841 W20199 AW664594 AW195667 D60123 D61496 AW468018 AI720097 N90553 AA829375 AW513266 H92758 AA585324 C14767 AI922391 D60124 D60666 AW071558 BE044120 AA728821 AA211941

120821 19274.2 Y19062 NM.014393 AW296801 AK001576 AL079288 W16667 Z45664 AI768561 AL079286 R12736 AW080147 AW136530 AI202958 AW241579 R21013 AA347419 AI929333 AW196689 AI040867 F13437 AA918240 AI869798 AI365176 AW440030 AW440072 N80892 AW242030 Z44807 R12417 AA436784 AA442041 AA046503 AL157526 AI929265 AA055542 AA045462 AA683542 N51374 AW193508 A1873524AW473151 AW004719 AI810504 AI581093 AA493977240600 F04553 R46130 F09321

106459 3897.1 AA789081 AW408328 NM.006530 U61384 AA449641 AW138216 AA448598 AJ245746 AI365301 N44728 AA255743 AA360783 BE550380 AW593925 AI962309 AA322097 AW964625 AI695988 AW672827 BE543256 AK001413 AW603395 AA651700 AA449053 AA465540 AW083185 T62128 Z78373 AW673713 AW468061 BE350755 AW673958 AW675504 AA995709 AW574841 AA835883 AI248439 AA548364 T62072 N33193 AA814046 AI376210 AI340020 AA449766 AA703407 AA427613 AI470108 AI298757 AA507602 A1658941 AA449478 AA633165 AA449741 AA831821 AA903673 AA682588 AW673075

115094 1909951 AA255920 AI817197 AA255921 AI612925 AW874669 AA493440 129571 1726J X51630 M80232 X61631 S75264 AA172249 AA134066 AA130278 AA130187 AA130291 AA031554 AI246677 Z21455 AI745434 AW273544 AW088613 AW471307 AI745483 AI399854 AI683952 AA031555 AA298075 AI935945 T29809 AA172099 AA356120

121779 2876651 AW513143 AA422036 AI821669 AW514232 AA477828 AW772009 AW439799 AW089884 106738 174703.1 AW149266 R49246 AW237401 AA938113 AW665871 AI969698 AI950812 AW874276 AI571939 AA741222 AI869822 AW104061 AI569994 AW972559 AA506012 AI553704 AA470145 AI332421 AA218990 AW131361 AI709076 AW392488 AW392477 AI970981 AW392476 D61949 H44981 BE172698

123005 75629.1 AW369771 AW748174AA290801 AA419198 AA044331 AA127909 AW995442 AI480343 AA044582AW956159AA373451 AA127965 AL134913 AW994956 BE622314 BE006298 BE006312 BE006305 BE006317 BE006303 AA043906 AA234175 AA479726

108055 100690.1 AJ404672 AJ289819 AW976000 AA043561 AW450885 AW452879 AA043562 AA788832 AI564338 AI564330 AI368875 AA643607 AA994375 AA810342 AI367704

115291 22325.1 BE545072 AI540751 AA301103 AI916675 N85422 BE563965 AA327978 AI816094 AK001515 BE501319 AA279943 BE138895 AA343765 AW963051 AW082308 AI823992 AI653752 AI589007 AI816135 AI566535 BE501307 AW272765 AW242239 AA766315 AI014927 AA578848 AI354483 AI476548 AI038579 AA973322 AA992180 AW472921 BE504789 AI392988 AA506076 AA769228 AI370562 AL137710 BE005656 AW965920

130376 24827.4 R40873 115536 61_1 AK001468 AA190315AA374980AW961179 AA307782AA315295 AA347194AW953073AW368190AW368192AA280772AA251247 N85676 AI215522 AI216389 N87835 R12261 R57094 AI660045 AA347193 R16712 AW119006 N55905 N87768 AW900167 AI341261 AI818674 D20285 AI475165 AA300756 R40626 AI122827 AA133250 AI952488 AA970372 AA889845 AW069517 AI524385 AA190314 AI673359 AA971105 A1351088 A1872789 AI919056 AI611216 AK001472 BE568761 AA581004

114965 1539551 AI733881 AA165164 AI826437 AI972791 AA165165 BE219575 AI732586 AI821571 AA250737 AW136875 AI984273 AI249271 131228 8262.1 AW207469 AL079814 AA354351 AF020043 AW291396 BE550484 NM.005445 BE046917 AW594249 AI651554 AI631515 AW771344 AI969758 AI699982 AA247175 AI244676 D44780 AW593978 AI638479 AI373676 AW089547 AL121432 AA554698 AI016991 AI087260 AW449939 AF067163 W40482 AW316558 AI537184 AW381979 W40150 AI810562 AA573151 AI630288 AI675561 AI674420 AW840733 AW022653 AA114219 AJ005015 AL046587 AA878141 AW271896 AW085287 AA150465 BE536295 AA463412 BE093222 AA213739 AA485586 A1825913AA706307 A1337348 R31995 AI819641 R32095 AW976653 AA742375 AA142957AI808214AW468303 AI205987 AI206347 AI769095 BE501640 AA113866 AI093931 AI752855 AA612743 AA463411 AA279157 AI123791 AA213570 AI207305 AW627814 R31945 R32040

116238 10772.1 AV660717 NM.015437AL050285 R95774 AI867094 AA443833 AI367670 AA609046 AI440298 A1613139 AI291826 AW028954 AI123242

AI824715 AW079750 AA479362AW150151 AI952267 AA814094 A1168431 AI566595 AI521422 AI920793 AW051241 N70051 AI689429 AI783813 AI769315 AI743691 AI915645 AA479473 C21435 N50944 N50902 AW978102 H23837 BE087538 AA316516

122802 287993 1 AI687303 AW571681 AI554465 AI684252 AI581056 AA604098 AI628160 AI859843 AA424021 AA460530 BE042778 AW273200 AW273223 AW167288AW083347AI654306 AW517496 AW104706 AW273214 BE139512AW189487 AW130822AW167419AI289485AW150010 H88004 AI743745 AW088710

123494 21202.1 AW179019 AW179011 AF135160 NM.014050 AF078860 BE018005 AK000285 AF151038 BE245156 AW179007 AA345114 BE619758 BE619209 W25509 AA314339 AA336674 AA337956 AW954843 AW390412 N46796 AA316235 AA314286 R15686 BE535633 N57134 N46483 AW368462 AA923517 AA665223 AI418513 AA837523 AI359320 AI309273 AI522278 N40939 AA904977 AA938272 N30240 AA887965 AI671972 AI028109 AA094652 AA883262 AA887781 AI744447 AW592944 AI077790 AW860883 AW148667 N89861 AA557195 AI191824 AI433166 AI719760 AA453089 AA630656 AA300976 AA639620 AW675033 AA284393 AW886987 AI476335 AI332939 BE301513 AA452920 AW674302 AI925483 AW170412 AI69871 AI375985 BE220535 AI688151 AW514809 AW062346 AA599786 BE350848 AI560848 AI023075 AA864875 AA166871 AI807947 AW514579 AI978602 AI860340 AA830886 AI374788 AI283592 AA683152 AA743159 AI379932 AI432056 AI128904 AW150433 N38909

116296 11967.2 AW149502 Z43342 AW002826 AL049382 AA442545 AW971471 BE220243 AW968952 AA043607 AW299245 AA659892 AI038768 H26330 BE463534 AI628252 AA836139 A1277291 AA489033AA741239 AI209064 AI300253 AI275761 Z39417 C01835

Table 9A lists about 382 genes up-regulated in ovanan cancer compared to normal ovanes These were selected from 35403 probesets on the Affy etπx/Eos Hu01 GeneChip array such that the ratio of "average" ovanan cancer to "average" normal adult ovanes was greater than or equal to 10 The "average" ovanan cancer level was set to the 2nd highest amongst vaπous ovanan cancers The "average" normal adult ovanes level was set to the aπthmetic mean amongst vaπous non malignant ovaries In order to remove gene-specific background levels of non specific hybπdization, the 15th percentile value amongst the non malignant tissues (see Table 7A) was subtracted from both the numerator and the denominator before the ratio was evaluated

TABLE 9A 382 UP-REGULATED GENES, OVARIAN CANCER VERSUS NORMAL OVARY

Pkey Pπmekey

Ex Accn Exemplar Accession *

UG ID UπiGene lD

Title UniGene title ratio ratio tumor vs normal tissues

Pkey Ex Accn UG ID Title ratio

134454 L33930 Hs 173996 CD24 antigen (small cell lung carcinoma clust 862

102927 X12876 Hs 65114 keratin 18 847

115909 AA436666 Hs 59761 ESTs 72 3

123169 AA488892 Hs 104472 ESTs, Weakly similar to Gag Pol polyprotein [ 668

115674 AA406542 Hs 71520 ESTs 654

102193 U20758 Hs 313 secreted phosphoprotein 1 (osteopontin, bone 63 1

101839 M93036 Hs 692 membrane component, chromosomal 4, surface ma 568

115221 AA262942 Hs 79741 ESTs 56 1

108059 AA043944 Hs 62663 ESTs 523

121853 AA425887 Hs 98502 ESTs 478

133504 W95070 Hs 74316 desmoplakin (DPI, DPII) 470

103546 Z14244 Hs 75752 cytochrome c oxidase subunit Vllb 46 5

100147 D13666 Hs 136348 osteoblast specific factor 2 (fasciclm I Ilk 455

102979 X17042 Hs 1908 proteoglycan 1, secretory granule 446

130967 AA134138 Hs 182579 Homo sapiens leucine aminopeptidase mRNA, com 445

102009 U02680 Hs 82643 protein tyrosine kinase 9 404

126960 AA317900 Hs 161756 ESTs 396

103111 X63187 Hs 2719 epididymis-specific, whey-acidic protein type 39 1

133829 AA453783 Hs 76550 Homo sapiens mRNA, cDNA DKFZp564B1264 (from c 390

111223 N68921 Hs 34806 ESTs, Weakly similar to πeogenin [H sapiens] 389

102803 U89916 Hs 26126 daudin 10 388

104943 AA065217 Hs 169674 ESTs 387

106605 AA457718 Hs 21103 Homo sapiens mRNA, cDNA DKFZp564B076 (from cl 384

120655 AA287347 Hs 238205 ESTs 38 1

102968 X16396 Hs 154672 methylene tetrahydrofolate dehydrogenase (NAD 36 3

104052 AA393164 Hs 97644 mammaglobin 2 360

109166 AA179845 Hs 73625 RAB6 interacting, kmesin like (rabkinesmθ) 359

101332 L47276 Homo sapiens (cell line HL-6) alpha topoisome 350

106167 AA425906 Hs 7956 ESTs 345

101042 J05428 Hs 10319 UDP glycosyltransferase 2 family, polypeptide 343

125852 H09290 Hs 76550 Homo sapiens mRNA, cDNA DKFZp564B1264 (from c 337

101201 L22524 Hs 2256 matπx metalloprotemase 7 (matπlysin, uteπ 323

126410 R51912 Hs 12409 somatostatin 32 1

134326 U16306 Hs 81800 chondroitin sulfate proteoglycan 2 (versican) 320

125739 AA428557 Hs 92137 v-myc avian myelocytomatosis viral oncogene h 31 6

132254 L20826 Hs 430 plastin 1 (I isoform) 31 4

112610 R79392 Hs 23643 ESTs 309

101441 M21005 Hs 100000 S100 calcium binding protein A8 (calgranulm 306

116345 AA496981 Hs 199067 HER3 receptor tyrosine kinase (c-erbB3, ERBB3 30 1

108860 AA133334 Hs 129911 ESTs 298

133859 U86782 Hs 178761 26S proteasome-associated padl homolog 292

107295 T34527 Hs 80120 UDP-N acetyl-alpha-D-galactosamine polypeptid 289

106210 AA428239 Hs 10338 ESTs 289

134711 X04011 Hs 88974 cytochrome b-245, beta polypeptide (chronic g 28 0

125769 AI382972 Hs 82128 5T4 oncofetal frophoblast glycoprotein 275

107222 D51235 Hs 82689 tumor rejection antigen (gp96) 1 274

102260 U28386 Hs 159557 karyopheπn alpha 2 (RAG cohort 1, importin a 269

134691 M59979 Hs 88474 prostaglandin endoperaxide synthase 1 (prosta 268

105588 AA279215 Hs 10867 ESTs 263

130718 N70196 Hs 18376 ESTs 263

111185 N67551 Hs 12844 EGF-like-domain, multiple 6 256

131965 W90146 Hs 35962 ESTs 256

132903 AA235404 Hs 5985 Homo sapiens clone 25186 mRNA sequence 256

114359 Z41589 Hs 153483 ESTs, Moderately similar to H1 chloπde chann 255 101185 L19872 Hs 170087 aryl hydrocarbon receptor 252

128742 D00763 Hs 251531 proteasome (prosome, macropain) subunit, alph 251

116724 F13665 Hs 65641 ESTs 249

111929 R40057 Hs 112360 prominin (mouse) like 1 249

102915 X07820 Hs 2258 matrix metalloprotemase 10 (stromelysiπ 2) 248

131210 AA430047 Hs 24248 ESTs 247

101714 M68874 Human phosphatidylcholme 2-acylhydrolase (cP 246

100154 D14557 Hs 81892 KIAA0101 gene product 246

134656 X14787 Hs 87409 thrombospondiπ 1 243

100294 D49396 Hs 75454 antioxidant protein 1 239

104080 AA402971 Hs 57771 kallιkreιn 11 237

107056 AA600310 Hs 18720 programmed cell death 8 (apoptosis-inducing f 237

115697 AA411502 Hs 63325 ESTs, Weakly similarto airway trypsm-like p 237

130350 U02020 Hs 239138 pre-B-cell colony-enhancing factor 237

105870 AA399623 Hs 23505 ESTs 236

118528 N67889 Hs 49397 ESTs 234

105309 AA233790 Hs 4104 ESTs, Weakly similar to cDNA EST yk386g75 co 232

109680 F09255 Hs 4993 ESTs 232

131501 AA121127 Hs 181307 H3 histone, family 3A 232

100824 HG4058 HT4328 Oncogene Aml1-Evι-1, Fusion Activated 23 1

111890 R38678 Hs 12365 ESTs 230

101543 M31166 Hs 2050 pentaxin-related gene, rapidly induced by IL- 228

102095 U11313 Hs 75760 sterol earner protein 2 228

114988 AA251089 Hs 94576 ESTs, Weakly similar to phosduciπ, retinal [H 228

120695 AA291468 ESTs 228

130941 D49394 Hs 2142 5-hydroxytryptamιne (serotonin) receptor 3A 228

106654 AA460449 Hs 3784 ESTs, Highly similarto phosphoseπne aminotr 227

109141 AA176428 Hs 193380 ESTs 226

102345 U37283 Hs 58882 Mιcrofibπl-assocιated lycoproteιn-2 226

115652 AA405098 Hs 38178 ESTs 224

100103 AF007875 Hs 5085 dolichyl phosphate mannosyltransferase polype 223

105463 AA253370 Hs 32646 ESTs 222

132624 AA164819 Hs 53631 ESTs 222

119743 W70242 Hs 58086 ESTs 220

132528 AA283006 Hs 50758 chromosome-associated polypeptide C 220

107174 AA621714 Hs 25338 ESTs 21 8

134495 D63477 Hs 84087 KIAA0143 protein 21 8

131985 AA434329 Hs 36563 ESTs 21 5

105832 AA398346 Hs 21898 ESTs 21 2

126160 N90960 Hs 247277 ESTs, Weakly similar to transformation-relate 21 2

114846 AA234929 Hs 44343 ESTs 20 9

109703 F09684 Hs 24792 ESTs, Weakly similar to ORF YOR283w [S cerevi 20 9

135154 AA126433 Hs 173242 sorting nexm 4 208

131185 M25753 Hs 23960 cyclin B1 207

105616 AA280670 Hs 24968 ESTs 205

131148 C00038 Hs 23579 ESTs 202

129337 R63542 Hs 110488 KIAA0990 protein 202

133640 D83004 Hs 75355 ubiquitin-conjugating enzyme E2N (homologous 201

127479 AA513722 Hs 179729 collagen, type X, alpha 1 (Schmid metaphyseal 199

133711 J04130 Hs 75703 small inducible cytokine A4 (homologous to mo 198

131818 Z39297 Hs 3281 neuronal penfraxin II 197

125303 Z39821 Hs 107295 ESTs 196

109112 AA169379 Hs 72865 ESTs 19 5

105376 AA236559 Hs 8768 ESTs, Weakly similar to "" ALU SUBFAMILY SQ 192

103605 Z35402 Hs 194657 cadheπn 1, E-cadheπn (epithelial) 191

100661 HG2874-HT3018 Ribosomal Protein L39 Homolog 191

129571 X51630 Hs 1145 Wilms tumor 1 190

115239 AA278650 Hs 73291 ESTs, Weakly similar to similar to the beta t 189

131562 U90551 Hs 28777 H2A histone family, member L 18 9

131272 AA423884 Hs 139033 paternally expressed gene 3 189

130343 AA490262 Hs 15485 ESTs, Weakly similar to APICAL-LIKE PROTEIN [ 188

103245 X76648 Hs 28988 glutaredoxin (thioltransferase) 187

101809 M86849 Homo sapiens connexin 26 (GJB2) mRNA, complet 18 6

105344 AA235303 Hs 8645 ESTs 184

135225 AA455988 Hs 9667 butyrobetaine (gamma), 2-oxoglutarate dioxyge 184

116786 H25836 Hs 83429 tumor necrosis factor (ligand) superfamily, m 183

131510 AA207114 Hs 27842 ESTs, Weakly similar to similar to 1-acyl-gly 182

124059 F13673 Hs 99769 ESTs 180

103352 X89398 Hs 78853 uracil-DNA glycosylase 179

132742 AA490862 Hs 55901 ESTs, Weakly similar to C43H8 1 [C elegans] 17 9

135242 M74093 Hs 9700 cyclin E1 179

123494 AA599786 Hs 112110 ESTs 178

129168 T90621 Hs 109052 chromosome 14 open reading frame 2 177

128517 AA280617 Hs 100861 ESTs, Weakly similar to p60 katanin [H sapien 176

130160 Z39228 Hs 151344 UDP-Gal betaGlcNAc beta 1,3-galactosyltraπsfe 176

103448 X99133 Hs 204238 lipocalin 2 (oncogene 24ρ3) 175

119708 W67810 Hs 57904 ago-nashi (Drosophila) homolog, praliferatio 17 5

122946 AA477445 Hs 105341 ESTs 17 5

125819 AA044840 Hs 251871 CTP synthase 175

131689 AA599653 Hs 30696 fraπscπption factor-like 5 (basic helix-loop 175

115061 AA253217 Hs 41271 ESTs 173

113702 T97307 Hs 161720 ESTs, Moderately similar to «" ALU SUBFAMIL 173

115291 AA279943 Hs 122579 ESTs 173

102567 U59863 Hs 146847 TRAF family member-associated NFKB activator 172 129229 AA211941 Hs.109643 polyadenylate binding protein-interacting pro 17.2

129351 AA167268 Hs.62349 Human ras inhibitor mRNA; 3' end 17.2

110769 N22222 yw34b06.s1 Morton Fetal Cochlea Homo sapiens 17.1

113182 T55234 Hs.9676 Human DNA sequence from clone 30M3 on chromos 17.0

115892 AA435946 Hs.50831 ESTs 17.0

123114 AA486407 Hs.105235 ESTs; Moderately similar to KIAA0454 protein 17.0

123442 AA598803 Hs.111496 ESTs 17.0

123339 AA504253 Hs.101515 ESTs 16.9

123689 AA609556 Hs.256562 ESTs 16.9

131941 D62657 Hs.35086 ubiquitin-specific protease 1 16.8

120649 AA287115 Hs.99697 ESTs 16.8

102139 U15932 Hs.2128 dual specificity phosphatase 5 16.8

115522 AA331393 Hs.47378 ESTs 16.7

135243 AA215333 Hs.97101 putative G protein-coupled receptor 16.6

131257 AA256042 Hs.24908 ESTs 16.5

109508 AA233892 Hs.55902 ESTs; Weakly similar to !!!! ALU SUBFAMILY SX 16.3

132701 AA279359 Hs.55220 BCL2-associated athanogene 2 16.3

134449 L34155 Hs.83450 laminin; alpha 3 (nicein (150kD); kalinin (16 16.3

126180 R18070 Hs.3712 ubiquinol-cytochrome c reductase; Rieske iron 16.3

106124 AA423987 Hs.7567 ESTs 16.2

115363 AA282071 Hs.152759 activator of S phase kinase 16.2

117588 N34895 Hs.44648 ESTs 16.1

131245 AA620599 Hs.24766 DKFZP564E1962 protein 16.1

101674 M61916 Hs.82124 laminin; beta 1 16.0

126819 AA305536 Hs.161489 ESTs 16.0

134039 S78569 Hs.78672 laminin; alpha 4 16.0

130648 AA075427 Hs.17296 ESTs; Weakly similar to /prediction 15.9

102823 U90914 Hs.5057 carboxypeptidase D 15.8

128470 AA447504 Hs.100261 Homo sapiens mRNA; cDNA DKFZp564B222 (from cl 15.8

115844 AA430124 Hs.234607 ESTs 15.7

132543 AA417152 Hs.5101 protein regulator of cytokinesis 1 15.7

130155 L33404 Hs.151254 kallikrein 7 (chymotryptic; stratum comeum) 15.7

101008 J04162 Hs.763 Fc fragment of IgG; low affinity Ilia; recept 15.7

120472 AA251875 Hs.104472 ESTs; Weakly similar to Gag-Pol polyprotein [ 15.6

116844 H64938 Hs.38331 ESTs 15.6

106753 AA476944 Hs.7331 ESTs 15.6

114767 AA148885 Hs.154443 minichromosome maintenance deficient (S. cere 15.5

114768 AA149007 Hs.182339 Ets homologous factor 15.5

127370 AI024352 Hs.70337 immunoglobulin superfamily; member 4 15.5

101507 M27492 Hs.82112 interieukin 1 receptor; type I 15.4

102519 U52969 Hs.80296 Purkinje cell protein 4 15.4

102610 U65011 Hs.30743 preferentially expressed antigen in melanoma 15.4

111244 N69556 Hs.24724 MFH-amplified sequences with leucine-rich tan 15.4

120404 AA234921 Hs.96427 KIAA1013 protein 15.3

130455 X17059 Hs.155956 N-acetyltransferase 1 (arylamine N-acetyltran 15.2

129519 AA298786 Hs.112242 ESTs 15.1

106553 AA454967 Hs.5887 ESTs; Highly similar to RNA binding motif pro 15.0

109502 AA233837 Hs.44755 ESTs; Weakly similar to membrane glycoprotein 14.9

115967 AA446887 Hs.42911 ESTs 14.9

104636 AA004415 Hs.106106 ESTs 14.9

134133 X93920 Hs.180383 dual specificity phosphatase 6 14.9

134444 X04470 Hs.251754 secretory leukocyte protease inhibitor (aπtil 14.8

132998 Y00062 Hs.170121 protein tyrosine phosphatase; receptor type; 14.8

131997 D82399 Hs.136644 Homo sapiens clone 23714 mRNA sequence 14.6

134056 R27358 Hs.7886 ESTs; Weakly similar to Pelle associated prot ' 14.6

101249 L33881 Hs.1904 protein kinase C; iota 14.5

105298 AA233459 Hs.26369 ESTs 14.5

107119 AA620307 Hs.27379 ESTs 14.5

115839 AA429038 Hs.40541 ESTs 14.5

122802 AA460530 Hs.256579 ESTs 14.5

129896 AA043021 Hs.13225 UDP-Gal:betaGlcNAc beta 1;4-galactosyltransf 14.3

130269 AA284694 Hs.168352 nucleoporin-like protein 1 14.3

134374 D62633 Hs.8236 ESTs 14.3

106370 AA443841 Hs.18676 sprouty (Drosophila) homolog 2 14.2

130919 AA291710 Hs.21276 collagen; type IV; alpha 3 (Goodpasture antig 14.1

132923 U21858 Hs.60679 TATA box binding protein (TBP)-associated fac 14.1

107968 AA034020 Hs.61539 ESTs 14.1

125390 H95094 Hs.75187 franslocase of outer mitochondrial membrane 2 14.1

107148 AA621131 Hs.5889 ESTs; Weakly similar to W01A11.2 gene product 14.1

110788 N24730 Hs.15420 ESTs 14.0

109481 AA233342 Hs.90680 ESTs; Weakly similar to WD40 protein Ciao 1 [ 13.9

105646 AA282147 Hs.5888 ESTs 13.9

106030 AA412251 Hs.12802 development and differentiation enhancing fx 13.8

132618 AA253330 Hs.5344 adaptor-related protein complex 1; gamma 1 su 13.7

133230 S82240 Hs.6838 ras homolog gene family; member E 13.7

124803 R45480 Hs.164866 cyclin K 13.6

121381 AA405747 Hs.97865 ESTs; Weakly similar to WASP-family protein [ 13.6

105200 AA195399 Hs.24641 ESTs 13.5

105627 AA281245 Hs.23317 ESTs 13.5

114986 AA251010 Hs.87807 ESTs 13.5

118036 N52844 Hs.196008 ESTs 13.5

134672 N79749 Hs.87627 ESTs; Weakly similar to cDNA EST EMBLT00542 13.5

110915 N46252 Hs.29724 ESTs 13.3

117984 N51919 Hs.47368 ESTs 13.3 132550 AA029597 Hs 170195 bone morphogenetic protein 7 (osteogenic prot 133

124315 H94892 Hs 6906 v-ral simian leukemia viral oncogene homolog 132

102547 U57911 Hs 46638 chromosome 11 open reading frame 8 132

125134 W19228 Hs 100748 ESTs 132

111806 R33468 Hs 24651 ESTs 131

106983 AA521195 Hs 10887 similar to lysosome-associated membrane glyco 130

106498 AA452141 Hs 7171 ESTs 130

110787 N24716 Hs 12244 ESTs, Weakly similar to C44B9 1 [C elegans] 130

122860 AA464414 Hs 112159 ESTs 130

131535 AA504642 Hs 28436 ESTs, Weakly similar to coded for by C elega 130

116188 AA464728 Hs 184598 ESTs 130

107243 D59489 Hs 34727 ESTs 129

129300 C20976 Hs 110165 ESTs, Highly similar to πbosomal protein L26 129

134487 R38185 Hs 83954 Homo sapiens unknown mRNA 128

102348 U37519 Hs 87539 aldehyde dehydrogenase 8 128

131839 H80622 Hs 33010 KIAA0633 protein 128

119620 W47620 Hs 56009 2'-5'olιgoadenylate synthetase 3 128

120802 AA343533 Hs 128777 ESTs, Weakly similar to predicted using Genef 127

102250 U28014 Hs 74122 caspase 4, apoptosis related cysteine proteas 127

105539 AA258873 Hs 25242 ESTs 127

114965 AA250737 Hs 72472 ESTs 127

118001 N52151 Hs 47447 ESTs 127

100448 D87469 Hs 57652 EGF-like-domam, multiple 2 126

130920 D50975 Hs 75525 calreticulm 126

131075 Y00757 Hs 2265 secretory granule, neuroendocπne protein 1 ( 126

105496 AA256323 Hs 25264 DKFZP434N126 protein 125

109235 AA193592 Hs 42300 ESTs, Weakly similarto "» ALU SUBFAMILY SQ 125

118215 N62195 Hs 77910 3-hydroxy-3-methylglutaryl-Coenzyme A synthas 125

134388 M15841 Hs 82575 small nuclear πbonucleoprotein polypeptide B 125

106897 AA489790 Hs 167496 RAN binding protein 6 124

133050 S67325 Hs 63788 propionyl Coenzyme A carboxylase, beta polype 124

109683 F09308 Hs 27607 ESTs 123

121463 AA411745 Hs 239681 ESTs, Weakly similar to KIAA0554 protein [H s 123

102876 X03663 Hs 174142 colony stimulating factor 1 receptor, formerl 122

101804 M86699 Hs 169840 TTK protein kinase 122

129017 H13108 Hs 107968 ESTs 121

105812 AA394126 Hs 20814 ESTs, Highly similar to CGI-27 protein [H sap 121

106459 AA449741 Hs 4029 glioma amplified sequence-41 120

107059 AA608545 Hs 23044 RAD51 (S cerevisiae) homolog (E coli RecA ho 120

107080 AA609210 Hs 19221 ESTs 120

110799 N26101 Hs 7838 Human ring zinc-finger protein (ZNF127-Xp) ge 120

112253 R51818 Hs 104222 Homo sapiens mRNA, cDNA DKFZp566L034 (from cl 120

116760 H11054 Hs 155342 protein kinase C, delta 120

120314 AA194166 Hs 221040 K1AA1038 protein 120

123005 AA479726 Hs 105577 ESTs 120

132572 AA448297 Hs 237825 signal recognition particle 72kD 120

110561 H59617 Hs 5199 ESTs, Weakly similarto UBIQUITIN-CONJUGATING 120

101923 S75256 HNL=neutrophιl lipocalin [human, ovanan cane 119

134992 H05625 Hs 92414 ESTs 11 8

105516 AA257971 Hs 21214 ESTs 11 8

105248 AA226968 Hs 22826 ESTs 11 7

109130 AA172040 Hs 20161 ESTs, Weakly similar to IgE receptor beta sub 117

115955 AA446121 Hs 44198 Homo sapiens BAC clone RG054D04 from 7q31 11 7

116135 AA460314 Hs 94179 ESTs 11 7

116284 AA487252 Hs 237809 ESTs, Weakly similar to hypothetical protein 11 7

132384 AA479933 Hs 46967 Human DNA sequence from clone 167A19 on chrom 117

134753 Y09216 Hs 173135 dual-specιficιty tyrosme-(Y)-phosphorylatιon 11 7

125136 W31479 Hs 129051 ESTs 11 7

133928 N34096 Hs 7766 ubiquitin-coπjugatmg enzyme E2E 1 (homologou 11 6

117395 N26330 Hs 93701 ESTs 11 5

127007 AA299360 EST11857 Uterus tumor I Homo sapiens cDNA 5 11 5

130567 L07493 Hs 1608 replication protein A3 (14kD) 11 5

135073 AA452000 Hs 94030 Homo sapiens mRNA, cDNA DKFZp586E1624 (from c 11 5

115140 AA258030 Hs 55356 ESTs, Weakly similar to supported by GENSCAN 11 4

115536 AA347193 Hs 62180 ESTs 11 4

133240 D31161 Hs 68613 ESTs 11 3

106521 AA453431 Hs 14732 malic enzyme 1, NADP(+)-dependent, cytosolic 11 3

107674 AA011027 Hs 41143 KIAA0581 protein 11 3

114149 Z38814 Hs 27196 ESTs 11 3

132478 H20906 Hs 49500 KIAA0746 protein 11 2

104252 AF002246 Hs 210863 cell adhesion molecule with homology to L1CAM 11 2

102436 U46499 Hs 790 microsomal glutathione S-transferase 1 11 2

106726 AA465339 Hs 7141 ESTs 11 2

100116 D00654 Hs 77443 actin, gamma 2, smooth muscle, enteπc 11 2

110970 N51374 Hs 96870 Homo sapiens mRNA full length insert cDNA clo 11 2

130417 U58522 Hs 155485 huntiπgtin interacting protein 2 11 2

132906 AA142857 Hs 234896 ESTs, Highly similar to gemmin [H sapiens] 11 2

107853 AA024427 Hs 59461 DKFZP434C245 protein 11 2

103467 Y00451 Hs 78712 aminolevulinate, delta-, synthase 1 11 1

100438 D87448 Hs 91417 topoisomerase (DNA) II binding protein 11 1

102654 U68494 Hs 24385 Human hbc647 mRNA sequence 11 1

103172 X68742 Hs 116774 integπn, alpha 1 11 1

106856 AA486183 Hs 15839 ESTs, Weakly similar to similar to oxysterol- 11 1

108255 AA063157 Hs 172608 ESTs 11 1 124308 H93575 Hs 227146 Homo sapiens mRNA, cDNA DKFZp564J142 (from cl 11 1

129057 X62466 Hs 214742 CDW52 antigen (CAMPATH-1 antigen) 11 1

128845 AA455658 Hs 10649 basement membrane induced gene 11 1

129025 AA420992 Hs 103441 ESTs, Weakly similar to testicular tektin B1- 11 0

107638 AA009528 Hs 42743 ESTs, Weakly similarto predicted using Genef 11 0

134480 AA024664 Hs 83916 NADH dehydrogenase (ubiqumone) 1 alpha subco 11 0

115262 AA279112 Hs 88594 ESTs 11 0

102580 U60808 Hs 152981 CDP-diacylglycerol synthase (phosphatidate cy 109

106614 AA458934 Hs 179912 ESTs 109

107115 AA610108 Hs 27693 ESTs, Highly similar to CGI-124 protein [H sa 109

115764 AA421562 Hs 91011 anteπor gradient 2 (Xeπepus laevis) homolog 109

121770 AA421714 Hs 11469 KIAA0896 protein 109

132191 AA449431 Hs 158688 KIAA0741 gene product 109

133214 Y10659 Hs 250911 interleukin 13 receptor, alpha 1 109

133914 N32811 Hs 77542 ESTs 108

101973 S82597 Hs 80120 UDP N acetyl alpha-D-galactosamine polypeptid 108

102669 U71207 Hs 29279 eyes absent (Drosophila) homolog 2 108

104147 AA451992 Hs 226799 ESTs, Highly similar to HSPC039 protein [H sa 108

106474 AA450212 Hs 42484 Homo sapiens mRNA, cDNA DKFZp564C053 (from cl 108

115881 AA435577 Hs 184942 G protein-coupled receptor 64 108

129950 M31516 Hs 1369 decay accelerating factor for complement (CD5 108

132783 N74897 Hs 5683 DEAD/H (Asp-Glu-Ala Asp/His) box polypeptide 108

133784 AA214305 Hs 76173 ESTs 108

134248 AA292677 Hs 80624 ESTs 108

105565 AA278302 Hs 18349 ESTs, Weakly„sιmιlar to partial CDS [C elegan 108

127999 AA837495 Hs 69851 ESTs, Weakly similar to Wiskott Aldnch syndr 108

108040 AA041551 Hs 48644 ESTs 107

130367 Z38501 Hs 8768 ESTs, Weakly similar to "" ALU SUBFAMILY SQ 107

108539 AA084677 Hs 54558 ESTs, Weakly similar to protein B [H sapiens] 107

111345 N89820 Hs 14559 ESTs 107

115583 AA398913 Hs 45231 LDOC1 protein 107

128965 T17440 Hs 107418 ESTs 107

101396 M15796 Hs 78996 proliferating cell nuclear antigen 106

132164 U84573 Hs 41270 procollagen lysine 2-oxoglutarate 5-dιoxygen 106

101275 L37936 Hs 3273 Ts translation elongation fxtor, mitochondπ 106

104660 AA007160 Hs 14846 Homo sapiens mRNA cDNA DKFZp564D016 (from cl 106

108609 AA100694 Hs 69499 Human DNA sequence from BAC 15E1 on chromosom 106

112041 R43300 Hs 22929 ESTs 106

114208 Z39301 Hs 7859 ESTs 106

118537 N67974 Hs 75431 fibπnogen, gamma polypeptide 10 6

106919 AA490885 Hs 21766 ESTs 106

115984 AA447687 Hs 91109 ESTs 106

105538 AA258860 Hs 32597 πng finger protein (C3H2C3 type) 6 106

102200 U21551 Hs 157205 branched chain aminotransferase 1, cytosolic 105

116710 F10577 Hs 70312 ESTs 105

119780 W72967 Hs 191381 ESTs, Weakly similarto hypothetical protein 105

112996 T23539 Hs 7165 zinc finger protein 259 105

103029 X54489 Hs 789 GR01 oncogene (melanoma growth stimulating ac 105

101255 L34600 Hs 149894 mitochondπal translational initiation factor 104

107032 AA599472 Hs 247309 succinate CoA ligase, GDP-formmg, beta subun 104

125617 AI287461 Hs 164950 ESTs 104

131475 Z39053 Hs 27263 ESTs 104

132073 N67408 Hs 38516 ESTs 104

101469 M22877 Hs 169248 Human somatic cytochrome c (HCS) gene, comple 103

102437 U46569 Hs 221986 aquaponn 5 103

104301 D45332 Hs 6783 ESTs 103

127236 AI341818 Hs 98658 budding uninhibited by benzimidazoles 1 (yeas 103

101465 M22612 Hs 241395 protease, seπne, 1 (trypsin 1) 103

113805 W42957 Hs 250617 ESTs 102

133536 Y00264 Hs 177486 amyloid beta (A4) precursor protein (protease 102

109799 F10770 Hs 180378 Homo sapiens clone 669 unknown mRNA, complete 102

113523 T90037 Hs 16686 ESTs 102

116195 AA465148 Hs 72402 ESTs 102

134542 X57025 Hs 85112 ιnsulιn-!ιke growth factor 1 (somatomedin C) 102

125298 Z39255 Hs 235350 YDD19 protein 102

119367 T78324 Hs 90905 ESTs 102

134470 X54942 Hs 83758 CDC28 protein kinase 2 102

134288 AA430008 Hs 8117 ESTs 101

105127 AA158132 Hs 11817 ESTs, Weakly similar to contains si ilaπty t 101

110627 H70485 Hs 35225 ESTs, Weakly similar to MBNL protein [H sapie 101

115188 AA261819 Hs 88367 ESTs 10 1

132632 N59764 Hs 5398 guanine monophosphate synthetase 101

124049 F10523 Hs 74519 pπmase, polypeptide 2A (58kD) 101

100079 AB002365 Hs 23311 KIAA0367 protein 100

113987 W87494 Hs 9641 ESTs, Moderately similar to COMPLEMENT C1Q SU 100

117280 N22107 Hs 172241 ESTs 100

TABLE 9B

Pkey Unique Eos probeset identifier number CAT number Gene cluster number

Accession Genbank accession numbers

Pkey CAT Number Accession

100661 23182.1 BE623001 L05096 AA383604AW966416 N53295 AA460213 AW571519 AA603655 101332 25130.1 J04088 NM.001067 AF071747 AJ011741 N85424 AL042407 AA218572 BE296748 BE083981 AL040877 AW499918 AW675045 H17813 BE081283 AA670403 AW504327 BE094229 AA104024 AI471482 AI970337 AA737616 AI827444 AW003286 AI742333 AI344044 A1765634 AI948838 AW235336 AW172827 AA095289 BE046383 AI734240 W16699 AI660329 AI289433 AA933778 A 469242 AA468838 AA806983 AA625873 W78031 BE206307 AA550803 AI743147 AI990075 AA948274 AA129533 AI635399 AA605313 AI624669 AW594319 AI221834 AI337434 AA307706 BE550282 AI760467 AI630636 AI221521 AW674314 AW078889 AI933732 AI686969 AI186928 AW074595 AI127486 AL079644 AI910815 H17814 AA310903 AW137854 T19279 AA026682 AA306035 AW383390 AW383389 AW383422 AW383427 AW383395 H09977 AA306247 AA352501 AW403639 F05421 AA224473 AA305321 H93904 AA089612 AW391543 AW402915 AW173382 AW402701 AW403113 R94438 N73126 H93466 AA090928 AA095051 T29025 AW951071 L47277 L47276 AI375913 BE384156 W24652 AA746288 AA568223 BE090591 H93033 N57027 AA504348 AA327653 AW959913 N53767 AA843715 AI453437 AW263710 AI076594 AA583483 AW873194 AW575166 AI128799 AI803319 AL042776 AW074313 AI887722 AI032284 AA447521 AI123885 N29334 AI354911 AW090687 AA236763 AA435535 AA236910 AA047124 AA236734 AW514610 H93467 AA962007 AI446783 AA127259 A1613495 AI686720 AI587374 AA936731 AA702453 AI859757 AA216786 AI251819 AI469227 AA806022 AI092324 N71868 AA968782 AA236919 AA809450 AA227220 AA765284 AI192007 AA768810 AA805794 AA729280 AA806238 AW768817 N71879 AI050686 AA505822 AA668974 AI688160 BE045915 AW466315 AA731314 AA649568 AA834316 AW591901 AW063876 AW294770 AI300266 AI336094 AI560380 AA721755 H09978 D20305 D29155 AW821790 BE150864 F01675 AI457474 AW466316 AA550969 AA630788

100824 5.36 AI393237 AI521317 AI761348 AF025841 D43968 AW994987 L34598 AF025841 D89789 D89788 D89790 AW998932 AI971742 AI310238 X90976 AW139668 AW674280 AI365552 AA877452 AV657554 C75229 AA376077 AI798056 AW609213 W25586 H30149 BE075089 BE075190AW580858 H99598 AA425238AA133916 AW363478 BE158121 BE158127 AW467960 BE158135 BE158126 BE158145 N92860 AA847246 AI961688 AI361423 AA878154 AA043767 AI863712 AI559226 AW339007 AI371266 AI368901 AA046624 AA134739 AW449154 AA130232 AI458720 AA962511 AI700627 R70437 AW004008 AA045229 AI671572 H99599 AA043768 AI685454 AI871685 N29937 X90977 AA524240 AI142114 AI825750 AI567805 AI631365 AI347893 AA134740 F20669 AA046707 AW793216 AW963298 AW959380AA363265 AI784593 AI268201 R69451 AV657618 AI695588

101714 30725.1 M68874 AL022147 M72393 AL049797 BE439441 T27650 AI766240 AW150345 AW778943 AI627464 BE439479 AA587049 AI277900 AI984983 A1630935 101809 32963.1 M86849 AA31528Q NM.004004 AA315269 BE142653 AA461400 AW802042 BE152893 AW383155 AA490688 AW117930 AW384563 AW384544 AW384566 AW378307 AW378323 AW839085 AA257102 AW378317 AW276060 AW271245 AW378298 AW384497 AI598114 AW264544 AI018136AW021810 AA961504 AW086214AW771489AW192483 AI290266AW192488 AW384490AW007451 AW890895 AA554460 AA613715 AW020066 AI783695 AI589498 AI917637 AW264471 AW384491 AI816732 AW368530 AW368521 AW368463 AA461087 AI341438 Ai970613 AI040737 A1418400 AA947181 AA962716 AI280695 AW769275 AW023591 A1160977 AA055400 N71882 AA490466 AW243772 AW316636 AI076554 AW511702 N69323 H88912 AA257017 AI952506 H88913 AI912481 AA600714 BE465701 N64149 C00523 N64240 AA677120

101923 30543 1 X99133 X83006 W38398 AA401137 AA298242 AA366738 AA308126 AW583781 AA298668 AW845024 BE140204 AW845005 U47734 AA837575 NM 005564 AA329732 AA421943 BE171567 S75256 AI750047 AI762213 AA100735 AW612993 AI474120 AW062884 AI940001 AW062852 AW062899 BE182639 AW778875 AA528093 AW517424 AI939989 AA076188 BE182636 AA169569 AA167439 AI283967 AA167783 AA076140 AI749649 AA166792 AI708618 AA400973 AA514773 AA514789 AA164458 AA167440 AA074845 AA421944 AA514874 AA079557 AA102361 AA587027 AA642930 AA878029 AA164459 AW176400 AW475086 AA857522 AA148193 AA838234 AA593897 AI284506 AW193324 AA148194 AW583341 AI669077 AW264913 AA074902 AI680515 AA169874 AA169614 AA079651 AW591737 AW190644 AA076565 AA662747 AA075896 AA535642 N27757 AI306666 AA074727 N79823 AA524360 AI826800 AA173827 BE140374 BE004062 AW265060 BE184103 AI199258 AA857853 AA299459 AA837890 AI626104 AA503624 BE183618 BE183717 AA573267 AI833071 AW270590 AA506601 BE004010 AA837854 AI675895 AI810491 AI184883 AW664712 AA076046 AA515574 AW352267 AI797418 AA172395 AI749194 AI559933 AA502597 AA321220 AI866124 AI695633 AA494293 AW085635 AA165649 AA165663

127007 19921.1 AB037771 BE005079 AA394189 AW959650 AA299360 AA398081 W37627 AW750817 AW630138 AI522058 BE326323 AA374890 AW418534AW997510AW995214AW959649 AA504426 D79223 D79621 AI276062 AI973155 AA653470 AA337887 AI382521 AW084427 D57078 W37628 AI610506 Z30230 AI567034 AA766091 H25097 H25078 AW991507 AA319736

110769 229824.1 BE000831 AA541787 AW173038 AA327931 AW117510 AW664665 AI066624 AI478955 AI863075 AI073744 AA490170 R46651 AI075653 F02865 N22222AW972956

120695 9683.3 AA976503 AI917802AA953664AA404613AA428771 BE280542 AW194691 AI927301 AI740458 AI796100 AI935603 AW052210 AA970201 AI633384 AA425910 AI017004 AI241295 AA402816 AA291468

Table 10A lists about 733 genes up-regulated in ovarian cancer compared to noπnal adult tissues. These were selected from 59680 probesets on the Affymefrix/Eos-Hύ03 GeneChip array such that the ratio of "average" ovarian cancer to "average" normal adult tissues was greater than or equal to 3.0. The "average" ovarian cancer level was set to the about the 80th percentile amongst various ovarian cancers. The "average" normal adult tissue level was set to the 90th percentile value amongst various non-malignant tissues. In order to remove gene-specific background levels of non-specific hybridization, the 15th percentile value amongst the non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated.

TABLE 10A: ABOUT 733 UP-REGULATED GENES, OVARIAN CANCER VERSUS NORMAL ADULT TISSUES

Pkey: Primekey

Ex. Accn: Exemplar Accession

UG ID: UniGene lD

Title: UniGene title ratio: ratio tumor vs normal tissues

Pkey Ex. Accn UG ID Title ratio

432938 T27013 Hs.3132 steroidogenic acute regulatory protein 56.1

418179 X51630 Hs.1145 Wilms tumor 1 33.5

400292 AA250737 Hs.72472 BMPR-lb; bone morphogenetic protein receptor 30.0

452838 U65011 Hs.30743 Preferentially expressed antigen in melanoma 29.5

415511 AI732617 Hs.182362 ESTs 28.1

422956 BE545072 Hs.122579 ESTs 28.1

410929 H47233 Hs.30643 ESTs 27.4

400289 X07820 Hs.2258 Matrix Metalloprotemase 10 (Stromolysin 2) 25.2

449034 AI624049 Hs.277523 gb:ts41a09.x1 NCI.CGAP.Ut1 Homo sapiens cDNA 23.7

427585 D31152 Hs.179729 collagen; type X; alpha 1 (Schmid metaphyseal 22.7

428392 H10233 Hs.2265 secretory granule, neuroendocrine protein 1 21.9

448243 AW369771 Hs.77496 ESTs 21.3

430691 C14187 Hs.103538 ESTs 21.2

444783 AK001468 Hs.62180 ESTs 20.8

407638 AJ404672 Hs.288693 EST 20.1

423739 AA398155 Hs.97600 ESTs 19.7

436982 AB018305 Hs.5378 spondin 1, (f-spoπdin) extracellular matrix p 19.0

451110 AI955040 Hs.301584 ESTs 18.8

426427 M86699 Hs.169840 TTK protein kinase 18.7 428227 AA321649 Hs.2248 INTERFERON-GAMMA INDUCED 18.3

419854 AW664873 Hs.87836 Homo sapiens PAC clone RP5-1087M19 from 7q11. 18.3

439706 AW872527 Hs.59761 ESTs 18.3

428579 NM 005756 Hs.184942 G protein-coupled receptor 64 17.4

410247 AF181721 Hs.61345 RU2S 17.0

428153 AW513143 Hs.98367 hypothetical protein FLJ22252 similarto SRY- 16.9

415076 NM.000857 Hs.77890 guanylate cyclase 1, soluble, beta 3 16.6

416209 AA236776 Hs.79078 MAD2 (mitotic arrest deficient, yeast, homolo 16.6

424905 NM 002497 Hs.153704 NIMA (never in mitosis gene a)-related kinase 16.2

423685 BE350494 Hs.49753 Homo sapiens mRNA for KIAA1561 protein, parti 15.9

428187 AI687303 Hs.285529 ESTs 15.9

438817 AI023799 Hs.163242 ESTs 15.9

424906 AI566086 Hs.153716 Homo sapiens mRNA for Hmob33 protein, 3' untr 15.9

407721 Y12735 Hs.38018 dual-specificity tyrosine-(Y)-phosphorylation 15.7

412723 AA648459 Hs.179912 ESTs 15.3

424717 H03754 Hs.152213 wingless-type MMTV integration site family, m 15.2

443646 AI085198 Hs.298699 ESTs 15.1

424345 AK001380 Hs.145479 Homo sapiens cDNA FLJ10518 fis, clone NT2RP20 14.8

428976 AL037824 Hs.194695 ras homolog gene family, member 1 14.6

418738 AW388633 Hs.6682 solute carrier family 7, member 11 14.3

428479 Y00272 Hs.184572 cell division cycle 2, G1 to S and G2 to M 14.2

436209 AW850417 Hs.254020 ESTs, Moderately similar to unnamed protein p 14.1

427356 AW023482 Hs.97849 ESTs 13.9

418601 AA279490 Hs.86368 calmegin 13.8

416661 AA634543 Hs.79440 IGF-II mRNA-binding protein 3 13.7

428532 AF157326 Hs.184786 TBP-interacting protein 13.6

402408 0 13.6

447350 AI375572 Hs.172634 ESTs; HER4 (c-erb-B4) 13.4

451807 W52854 Hs.27099 DKFZP564J0863 protein 13.4

423575 C18863 Hs.163443 ESTs 13.2

443211 AI128388 Hs.143655 ESTs 13.2

437872 AK002015 Hs.5887 RNA binding motif protein 7 13.0

451659 BE379761 Hs.14248 ESTs, Weakly similar to ALU8.HUMAN ALU SUBFAM 12.7

452904 AL157581 Hs.30957 Homo sapiens mRNA; cDNA DKFZp434E0626 (from c 12.7

442655 AW027457 Hs.30323 ESTs 12.5

452096 BE394901 Hs.226785 ESTs 12.4

414972 BE263782 Hs.77695 KIAA0008 gene product 12.3

435039 AW043921 Hs.130526 ESTs 12.3

447033 AI357412 Hs.157601 EST- notin UniGeπe 12.3

433764 AW753676 Hs.39982 ESTs 12.2

442611 BE077155 Hs.177537 ESTs 12.0

408562 AI436323 Hs.31141 Homo sapiens mRNA for KIAA1568 protein, parti 11.9

427344 NM 000869 Hs.2142 5-hydroxytryptamine (serotonin) receptor 3A 11.8

421478 AI683243 Hs.97258 ESTs 11.8

426635 BE395109 Hs.129327 ESTs 11.8

415989 AI267700 Hs.111128 ESTs 11.7

433159 AB035898 Hs.150587 kinesin-like protein 2 11.5

452249 BE394412 Hs.61252 ESTs 11.4

418506 AA084248 Hs.85339 G protein-coupled receptor 39 11.3

442353 BE379594 Hs.49136 ESTs 11.3

447700 AI420183 Hs.171077 ESTs, Weakly similar to similar to serine/thr 11.3

450480 X82125 Hs.25040 zinc finger protein 239 11.3

425176 AW015644 Hs.301430 ESTs, Moderately similar to TEF1.HUMAN TRANSC 11.2

435496 AW840171 Hs.265398 ESTs, Weakly similar to transformation-relate 11.2

433133 AB027249 Hs.104741 PDZ-binding kinase; T-cell originated protein 11.1

445258 AI635931 Hs.147613 ESTs 11.1

432677 NM 004482 Hs.278611 UDP-N-acetyl-alpha-D-galactosamine:polypeptid 11.0

429782 NM.005754 Hs.220689 Ras-GTPase-activating protein SH3-domain-bind 10.9

404567 0 10.8

423811 AW299598 Hs.50895 homeo box C4 10.7

452891 N75582 Hs.212875 ESTs, Weakly similar to KIAA0357 [H.sapiens] 10.6

441627 AA947552 Hs.58086 ESTs 10.3

443555 N71710 Hs.21398 ESTs, Moderately similar to GNPI.HUMAN GLUCOS 10.3

412140 AA219691 Hs.73625 RAB6 interacting, kinesin-like (rabkinesinθ) 10.2

427469 AA403084 Hs.269347 ESTs 10.1

415227 AW821113 Hs.72402 ESTs 10.1

445413 AA151342 Hs.12677 CGI-147 protein 10.0

425734 AF056209 Hs.159396 peptidylglycine alpha-amidating monooxygenase 10.0

421451 AA291377 Hs.50831 ESTs 10.0

410044 BE566742 Hs.58169 highly expressed in cancer, rich in leucine h 9.8

427878 C05766 Hs.181022 CGI-07 protein 9.7

408460 AA054726 Hs.285574 ESTs 9.7

422972 N59319 Hs.145404 ESTs 9.7

443715 AI583187 Hs.9700 cyclin E1 9.7

440901 AA909358 Hs.128612 ESTs 9.6

453160 AI263307 Hs.146228 ESTs 9.6

415211 R64730.comp Hs.155986 ESTs; Highly similar to SPERM SURFACE PROTEIN 9.5

425282 AW163518 Hs.155485 huntiπgtin interacting protein 2 9.5

400250 0 9.5

410568 AW162948 Hs.64542 pre-mRNA cleavage factor Im (68kD) 9.3

442957 AI949952 Hs.49397 ESTs 9.3

453922 AF053306 Hs.36708 budding uninhibited by benzimidazoles 1 (yeas 9.3

434401 AI864131 Hs.71119 Putative prostate cancer tumor suppressor 9.2

453628 AW243307 Hs.170187 . ESTs 9.1 452055 AI377431 Hs 293772 ESTs 91

424086 AI351010 Hs 102267 lysyl oxidase 91

442875 BE623003 Hs 23625 Homo sapiens clone TCCCTA00142 mRNA sequence 91

416208 AW291168 Hs 41295 ESTs 90

407168 R45175 Hs 117183 gb yg40f01 s1 Soares infant brain 1NIB Homos 90

445537 AJ245671 Hs 12844 EGF-like-domam, multiple 6 89

409269 AA576953 Hs 22972 Homo sapiens cDNA FU13352 fis, clone OVARC10 89

433527 AW235613 Hs 133020 ESTs 89

409928 AL137163 Hs 57549 hypothetical protein dJ473B4 88

423020 AA383092 Hs 1608 replication protein A3 (14kD) 87

425665 AK001050 Hs 159066 ESTs 86

443204 AW205878 Hs 29643 Homo sapiens cDNA FLJ13103 fis, clone NT2RP30 86

449433 AI672Q96 Hs 9012 ESTs 86

453878 AW964440 Hs 19025 ESTs 86

450505 NM.004572 Hs 25051 plakophil 2 86

407001 U12471 Hs 247954 Human thrombospondιn-1 gene, partial eds 85

414315 Z24878 gb HSB65D052 STRATAGENE Human skeletal muscle 85

425492 AL021918 Hs 158174 zinc finger protein 184 (Kr ppel like) 85

435181 AA669339 Hs 28838 KIAA1571 protein 85

436396 AI683487 Hs 299112 Homo sapiens cDNA FLJ11441 fis, clone HEMBA10 85

418384 AW149266 Hs 25130 ESTs 84

453370 AI470523 Hs 182356 ESTs, Moderately similar to translation imti 84

409041 AB033025 Hs 50081 KIAA1199 protein 84

447078 AW885727 Hs 301570 ESTs 84

448674 W31178 Hs 154140 ESTs 83

433393 AF038564 Hs 98074 atrophm-1 interacting protein 4 83

433496 AF064254 Hs 49765 VERY-LONG-CHAIN ACYL-COA SYNTHETASE 83

421155 H87879 Hs 102267 lysyl oxidase 82

438394 BE379623 Hs 27693 CGI-124 protein 82

400298 AA032279 Hs 61635 STEAP1 81

409092 AI735283 Hs 172608 ESTs 8 1

440250 AA876179 Hs 134650 ESTs 81

409143 AW025980 Hs 138965 ESTs 81

407771 AL138272 Hs 62713 ESTs 81

419088 AI538323 Hs 77496 ESTs 81

431725 X65724 Hs 2839 Nome disease (pseudoglioma) 79

431750 AA514986 Hs 283705 ESTs 79

435635 AF220050 Hs 181385 uncharacterized hematopoietic stem progenitor 79

441826 AW503603 Hs 129915 phosphotπesterase related 79

417728 AW138437 Hs 24790 KIAA1573 protein 78

418845 AA852985 Hs 89232 chromobox homolog 5 (Drosophila HP1 alpha) 78

421039 NM.003478 Hs 101299 cullin 5 78

446999 AA151520 Hs 279525 hypothetical protein PRO2605 78

429609 AF002246 Hs 210863 ceil adhesion molecule with homology to L1CAM 78

415139 AW975942 Hs 48524 ESTs 77

450192 AA263143 Hs 24596 RAD51-ιnteractιng protein 77

423992 AW898292 Hs 137206 Homo sapiens mRNA, cDNA DKFZp564H1663 (from c 77

436211 AK001581 Hs 80961 polymerase (DNA directed), gamma 77

450101 AV6499B9 Hs 24385 Human hbc647 mRNA sequence 75

426921 AA037145 Hs 172865 cleavage stimulation factor, 3' pre-RNA, subu 75

433330 AW207084 Hs 132816 ESTs 75

439759 AL359055 Hs 67709 Homo sapiens mRNA full length insert cDNA do 75

427660 AI741320 Hs 114121 Homo sapiens cDNA FU23228 fis, clone CAE066 75

422095 AI868872 Hs 288966 ceruloplasmin (ferroxidase) 75

436476 AA326108 Hs 53631 ESTs 75

412170 D16532 Hs 73729 very low density lipoprotein receptor 74

428954 AF100781 Hs 194678 WNT1 inducible signaling pathway protein 3 74

450221 AA328102 Hs 24641 cytoskeleton associated protein 2 74

439262 AA832333 Hs 124399 ESTs 74

435420 AI928513 Hs 59203 ESTs 73

422892 AA988176 Hs 121553 hypothetical protein FLJ20641 73

457030 AI301740 Hs 173381 dihydropyπmidmase-like 2 73

411571 AA122393 Hs 70811 hypothetical protein FU20516 72

409916 BE313625 Hs 57435 solute camerfamily 11 (proton-coupled diva 72

418007 M13509 Hs 83169 Matπx metalloprotease 1 (interstitial collag 72

420900 AL045633 Hs 44269 ESTs 72

424001 W67883 Hs 137476 KIAA1051 protein 72

400301 X03635 Hs 1657 Estrogen receptor 1 71

400238 0 7 1

413573 AI733859 Hs 149089 ESTs 71

428071 AF212848 Hs 182339 transcπption factor ESE-3B 71

447164 AF026941 Hs 17518 Homo sapiens cιg5 mRNA, partial sequence 71

453062 AW207538 Hs 61603 ESTs 71

456965 AW131888 Hs 172792 ESTs, Weakly similar to hypothetical protein 71

442500 AI819068 Hs 209122 ESTs 71

446142 AI754693 Hs 145968 ESTs 70

417791 AW965339 Hs 111471 ESTs 70

418524 AA300576 Hs 85769 acidic 82 kDa protein mRNA 70

451797 AW663858 Hs 56120 ESTs 70

452909 NM 015368 Hs 30985 pannexm 1 70

453616 NM 003462 Hs 33846 dynem, axonemal, light intermediate polypept 70

436281 AW411194 Hs 120051 ESTs 70

449897 AW819642 Hs 24135 transmembrane protein vezatin, hypothetical p 69

414142 AW368397 Hs 150042 ESTs 69 448776 BE302464 Hs 30057 transporter similar to yeast MRS2 69

419423 D26488 Hs 90315 KIAA0007 protein 69

420908 AL049974 Hs 100261 Homo sapiens mRNA, cDNA DKFZp564B222 (from cl 68

452971 A1873878 Hs 91789 ESTs 68

413597 AW302885 Hs 117183 ESTs 68

415138 C18356 Hs 78045 tissue factor pathway inhibitor 2 TFPI2 68

437478 AL390172 Hs 118811 ESTs 67

425292 NM 005824 Hs 155545 37 kDa leucine πch repeat (LRR) protein 67

421184 NM.003616 Hs 102456 survival of motor neuron protein interacting 67

410227 AB009284 Hs 61152 exostoses (multiple) like 2 66

446608 N75217 Hs 257846 ESTs 66

438167 R28363 Hs 24286 ESTs 66

445459 AI478629 Hs 158465 ESTs 66

452291 AF015592 Hs 28853 CDC7 (cell division cycle 7, S cerevisiae, h 66

410011 AB020641 Hs 57856 PFTAIRE protein kinase 1 66

410292 AA843087 Hs 124194 ESTs 65

415716 N59294 Hs 301141 Homo sapiens cDNA FLJ11689 fis, clone HEMBA10 65

424770 AA425562 gb zw46e05 r1 Soares total fetus_Nb2HF8 9w Ho 65

438122 AI620270 Hs 129837 ESTs 65

439820 AL360204 Hs 283853 Homo sapiens mRNA full length insert cDNA clo 65

444743 AA045648 Hs 11817 nudix (nucleoside diphosphate linked moiety X 65

450638 AK001826 Hs 25245 hypothetical protein FL111269 65

418203 X54942 Hs 83758 CDC28 protein kinase 2 65

439901 N73885 Hs 124169 ESTs b 5

428758 AA433988 Hs 98502 Homo sapiens cDNA FLJ 14303 fis, clone PLACE20 64

404552 0 64

404599 0 64

419503 AA243642 Hs 137422 ESTs 64

420149 AA255920 Hs 88095 ESTs 64

440411 N30256 Hs 156971 ESTs, Weakly similar to Weak similarity with 64

449108 AI140683 Hs 98328 ESTs 64

452097 AB002364 Hs 27916 ADAM-TS3 , a dismtegπn like and metallopr 64

453619 H87648 Hs 33922 H sapiens novel gene from PAC 117P20, chromos 64

410273 BE326877 Hs 281523 ESTs 63

434486 AA678816 Hs 117142 ESTs 63

454036 AA374756 Hs 93560 ESTs, Weakly similar to unnamed protein produ 63

403381 0 62

421308 AA687322 Hs 192843 ESTs 62

419346 AI830417 gb wh94d12 x1 NCI.CGAP.CLL1 Homo sapiens cDNA 62

446140 AA356170 Hs 26750 Homo sapiens cDNA FLJ21908 fis clone HEP038 62

453047 AW023798 Hs 286025 ESTs 62

442573 H93366 Hs 7567 Branched chain aminotransferase 1, cytosolic, 6 1

410102 AW248508 Hs 279727 ESTs, 6 1

410004 AI298027 Hs 299115 ESTs 61

413335 AI613318 Hs 48442 ESTs 6 1

424945 AI221919 Hs 173438 hypothetical protein FU 10582 6 1

427510 Z47542 Hs 179312 small nuclear RNA activating complex, polypep 6 1

451229 AW967707 Hs 48473 ESTs 6 1

452641 AW952893 Hs 237825 signal recognition particle 72kD 6 1

433172 AB037841 Hs 102652 hypothetical protein ASH1 6 1

425465 L18964 Hs 1904 protein kinase C, iota 6 1

437117 AL049256 Hs 122593 ESTs 60

423440 R25234 Hs 143434 contactin 1 60

430510 AW162916 Hs 241576 hypothetical protein PR02577 60

433252 AB040957 Hs 151343 KIAA1524 protein 60

434699 AA643687 Hs 149425 Homo sapiens cDNA FLJ11980 fis, clone HEMBB10 60

436954 AA740151 Hs 130425 ESTs 59

436032 AA150797 Hs 109276 latexiπ protein 59

424590 AW966399 Hs 46821 hypothetical protein FU20086 59

444078 BE246919 Hs 10290 U5 snRNP-specific 40 kDa protein (hPrpβ-bmdi 59

418379 AA218940 Hs 137516 fidgetin like 1 59

438081 H49546 Hs 298964 ESTs 58

443270 NM 004272 Hs 9192 Homer, neuronal immediate eariy gene, 1B 58

450459 AI697193 Hs 299254 ESTs 58

433612 AF078164 Hs 61188 Homo sapiens Ku70 binding protein (KUB3) mRNA 58

449048 Z45051 Hs 22920 similar to S68401 (cattle) glucose induced ge 58

417251 AW015242 Hs 99488 ESTs, Weakly similarto ORF YKR074w [S cerevi 57

429181 AW979104 Hs 294009 ESTs 57

454933 BE141714 gb QV0 HT0101-061099 032-c04 HT0101 Homo sapi 57

456553 AA721325 Hs 189058 ESTs, Weakly similar to cAMP regulated guaniπ 57

430371 D87466 Hs 240112 KIAA0276 protein 57

425371 D49441 Hs 155981 mesothelin 57

424513 BE385864 Hs 149894 mitochondπal translational initiation factor 56

432015 AL157504 Hs 159115 ESTs 56

438109 AI076621 Hs 71367 ESTs, Moderately similar to ALU7.HUMAN ALU SU 56

407137 T97307 Hs 199067 v-erb-b2 avian erythroblastic leukemia viral 56

407945 X69208 Hs 606 ATPase, Cu++ transporting, alpha polypeptide 56

416565 AW000960 Hs 44970 ESTs 56

417830 AW504786 Hs 132808 epithelial cell transforming sequence 2 oncog 55

419752 AA249573 Hs 152618 ESTs 55

422093 AF151852 Hs 111449 CGI-94 protein 55

424583 AF017445 Hs 150926 fucose-1-phosphate guanylyItransferase 55

430388 AA356923 Hs 240770 nuclear cap binding protein subunit 2, 20kD 55

452534 AW083022 Hs 149425 Homo sapiens cDNA FU11980 fis clone HEMBB10 55 453279 AW893940 Hs 59698 ESTs 55

424188 AW954552 Hs 142634 zinc finger protein 55

453884 AA355925 Hs 36232 KIAA0186 gene product 55

424641 AB001106 Hs 151413 glia maturation factor, beta 55

444478 W07318 Hs 240 M-phase phosphoprotein 1 55

427975 AI536065 Hs 122460 ESTs 55

424620 AA101043 Hs 151254 kallikrem 7 (chymotryptic, stratum corneum) 55

442914 AW188551 Hs 99519 Homo sapiens cDNA FLJ14007 fis, clone Y79AA10 55

417995 AW974175 Hs 188751 ESTs 54

418946 AI798841 Hs 132103 ESTs 54

419963 AA743276 Hs 301052 ESTs 54

420362 U79734 Hs 97206 huntingt interacting protein 1 54

422670 AA371612 Hs 115351 ESTs 54

432837 AA310693 Hs 279512 HSPC072 protein 54

447020 T27308 Hs 16986 hypothetical protein FU11046 54

458027 L49054 Hs 85195 ESTs, Highly similar to t(3,5)(q25 1 ,p34) fus 54

425217 AU076696 Hs 155174 CDC5 (cell division cycle 5, S pombe, homolo 54

422938 NM 001809 Hs 1594 centromere protein A (17kD) 54

450434 AA166950 Hs 18645 ESTs, Weakly similar to partial CDS [C elegan 54

438279 AA805166 Hs 165165 ESTs, Moderately similar to ALU8.HUMAN ALU SU 54

413384 NM 000401 Hs 75334 exostoses (multiple) 2 53

420328 Y19062 Hs 96870 staufen (Drosophila, RNA-biπdmg protein) horn 53

436586 A1308862 Hs 167028 ESTs 53

435793 AB037734 Hs 4993 ESTs 53

422306 BE044325 Hs 227280 Homo sapiens mRNA for Lsm5 protein 53

425154 NM 001851 Hs 154850 collagen, type IX, alpha 1 52

453293 AA382267 Hs 10653 ESTs 52

429944 R13949 Hs 226440 Homo sapiens clone 24881 mRNA sequence 52

434891 AA814309 Hs 123583 ESTs 52

415263 AA948033 Hs 130853 ESTs 52

409506 NM.006153 Hs 54589 NCK adaptor protein 1 52

412848 AA121514 Hs 70832 ESTs 52

421246 AW582962 Hs 300961 ESTs, Highly similar to AF151805 1 CGI47 pro 52

431548 AI834273 Hs 9711 Homo sapiens cDNA FLJ13018 fis, clone NT2RP30 52

412719 AW016610 Hs 129911 ESTs 52

411945 AL033527 Hs 92137 v-myc avian myelocytomatosis viral oncogene h 5 1

424078 AB006625 Hs 139033 paternally expressed gene 3 5 1

433558 AA833757 Hs 201769 ESTs 5 1

434265 AA846811 Hs 130554 Homo sapiens cDNA FLJ23089 fis, clone LNG070 5 1

453911 AW503857 Hs 4007 Sarcolemmal-assoctated protein 51

415539 AI733881 Hs 72472 BMPR-lb, bone morphogenetic protein receptor 51

442717 R88362 Hs 180591 ESTs, Weakly similar to R06F65b [C elegans] 51

432358 AI093491 Hs 72830 ESTs 50

409731 AA125985 Hs 56145 thymosin, beta identified in neuroblastoma c 50

419699 AA248998 Hs 31246 ESTs 50

420313 AB023230 Hs 96427 KIAA1013 protein 50

422505 AL120862 Hs 124165 ESTs, (HSA)PAP protein (programmed cell deat 50

425733 F13287 Hs 159388 Homo sapiens clone 23578 mRNA sequence 50

434160 BE551196 Hs 114275 ESTs 50

435094 AI560129 Hs 277523 EST 50

436812 AW298067 gb UI-H-BWO-ajp-g-09 0-UI s1 NCI CGAP.Subδ Ho 50

432415 T16971 Hs 289014 ESTs 49

406117 0 49

438018 AK001160 Hs 5999 hypothetical protein FLJ10298 49

447505 AL049266 Hs 18724 Homo sapiens mRNA, cDNA DKFZp564F093 (from cl 49

448621 AI097144 Hs 5250 ESTs, Weakly similar to BACR37P7 g [D melanog 49

453001 AW131636 Hs 191260 ESTs 49

410561 BE540255 Hs 6994 Homo sapiens cDNA FLJ22044 fis, clone HEP091 49

418811 AK001407 Hs 88663 hypothetical protein FU10545 49

436754 AI061288 Hs 133437 ESTs, Moderately similarto gonadotropin indu 48

437212 AI765021 Hs 210775 ESTs 48

447312 AI434345 Hs 36908 activating franscπption factor 1 48

409732 NM 016122 Hs 56148 NY-REN 58 antigen 48

434690 AI867679 Hs 148410 ESTs 48

444172 BE147740 Hs 104558 ESTs 48

424539 L02911 Hs 150402 activin A receptor, type I 48

418677 S83308 Hs 87224 SRY (sex determining region Y) box 5 48

406076 AL390179 Hs 137011 Homo sapiens mRNA, cDNA DKFZp547P134 (from cl 48

420179 N74530 Hs 21168 ESTs 47

450375 AA009647 Hs 8850 a dismtegπn and metalloprotemase domain 12 47

419247 S65791 Hs 89764 fragile X mental retardation 1 47

420850 BE139590 Hs 122406 ESTs 47

425420 BE536911 Hs 234545 ESTs 47

428664 AK001666 Hs 189095 similarto SALL1 (sal (Drosophila) like 47

419131 AA406293 Hs 301622 ESTs 47

422278 AF072873 Hs 114218 ESTs 47

451684 AF216751 Hs 26813 CDA14 46

400296 AA305627 Hs 139336 ATP-binding cassette, sub-family C (CFTR/MRP) 46

408425 AW058674 Hs 44787 Homo sapiens mRNA, cDNA DKFZp434O0227 (from c 46

417168 AL133117 Hs 81376 Homo sapiens mRNA, cDNA DKFZp586L1121 (from c 46

429486 AF155827 Hs 203963 hypothetical protein FU10339 46

442917 AA314907 Hs 85950 ESTs 46

443268 AI800271 Hs 129445 hypothetical protein FU 12496 46

452795 AW392555 Hs 18878 hypothetical protein FU21620 46 457300 AW297436 Hs 158849 Homo sapiens cDNA FU21663 fis, clone COL088 46

459551 AI472808 gb tj70e07 x1 Soares_NSF_F8_9W_OT_PA_P_S1 Horn 46

421977 W94197 Hs 110165 πbosomal protein L26 homolog 46

429441 AJ224172 Hs 204096 lipophilm B (uteroglobm family member), pro 46

449722 BE280074 Hs 23960 cyclin B1 46

431689 AA305688 Hs 267695 UDP-Gal betaGlcNAc beta 1,3-galactosyltransfe 45

425178 H16097 Hs 161027 ESTs 45

429597 NM 003816 Hs 2442 a dismtegπn and melalloproteinase domain 9 45

436556 AI364997 Hs 7572 ESTs 45

400534 0 45

417845 AL117461 Hs 82719 Homo sapiens mRNA, cDNA DKFZp586F1822 (from c 45

423123 NM.012247 Hs 124027 SELENOPHOSPHATE SYNTHETASE , Human selenium d 45

448305 AA625207 Hs 264915 Homo sapiens cDNA FLJ12908 fis, clone NT2RP20 45

441006 AW605267 Hs 7627 CGI-60 protein 45

414569 AF109298 Hs 118258 Prostate cancer associated protein 1 45

447924 AI817226 Hs 170337 ESTs 45

425506 NM 003666 Hs 158205 basic leucine zipper nuclear factor 1 (JEM-1) 45

411630 U42349 Hs 71119 Putative prostate cancer tumor suppressor 44

432842 AW674093 Hs 279525 hypothetical protein PRO2605 44

413472 BE242870 Hs 75379 solute earner family 1 (glial high affinity 44

414699 AI815523 Hs 76930 synuclein, alpha (non A4 component of amyloid 44

412733 AA984472 Hs 74554 KIAA0080 protein 44

419790 U79250 Hs 93201 glycerol-3-phosphate dehydrogenase 2 (mitocho 44

433377 AI752713 Hs 43845 ESTs 44

449535 W15267 Hs 23672 low density lipoprotein receptor-related prot 44

453900 AW003582 Hs 226414 ESTs, Weakly similar to ALU8.HUMAN ALU SUBFAM 44

443881 R64512 Hs 237146 Homo sapiens cDNA FU14234 fis, clone NT2RP40 44

423025 AA831267 Hs 12244 Homo sapiens cDNA FLJ23581 fis, clone LNG136 44

408621 AI970672 Hs 46638 chromosome 11 open reading frame 8, fetal br 43

416241 N52639 Hs 32683 ESTs 43

432005 AA524190 Hs 120777 ESTs, Weakly similar to ELL2.HUMAN RNA POLYME 43

435532 AW291488 Hs 117305 ESTs 43

451813 NM 016117 Hs 27182 phospholipase A2-actιvatιng protein 43

454193 BE141183 gb MR0-HT0071-191199-001-b04 HT0071 Homo sapi 43

418478 U38945 Hs 1174 cyclm-dependent kinase inhibitor 2A (melanom 43

406069 0 43

419465 AW500239 Hs 21187 Homo sapiens cDNA FU23068 fis, clone LNG055 43

418413 R95735 Hs 117753 ESTs, Weakly similar to antigen ofthe monocl 43

452028 AK001859 Hs 27595 hypothetical protein FU 10997 43

418693 AI750878 Hs 87409 thrombospondin 1 43

410361 BE391804 Hs 62661 guanylate binding protein 1, interferon indue 42

409763 AL043212 gb DKFZp434H0623_r1 434 (synonym htes3) Homo 42

455601 AI368680 Hs 816 SRY (sex determining region Y) box 2, partial 42

408908 BE296227 Hs 48915 seππe/threoniπe kinase 15 42

413582 AW295647 Hs 71331 Homo sapiens cDNA FU21971 fis, clone HEP057 42

423248 AA380177 Hs 125845 nbulose 5-phosphate 3-epιmerase 42

425024 R39235 Hs 12407 ESTs 42

447153 AA805202 Hs 173912 eukaryotic translation initiation factor 4A, 42

447406 BE618060 Hs 282882 ESTs 42

449347 AV649748 Hs 295901 ESTs 42

414279 AW021691 Hs 3804 DKFZP564C1940 protein 42

428856 AA436735 Hs 183171 Homo sapiens cDNA FLJ22002 fis, clone HEP066 42

407872 AB039723 Hs 40735 fπzzled (Drosophila) homolog 3 42

421502 AF111856 Hs 105039 solute earner family 34 (sodium phosphate), 42

436406 AW1Q5723 Hs 125346 ESTs 42

438209 AL120659 Hs 6111 KIAA0307 gene product 42

443653 AA137043 Hs 9663 programmed cell death 6-ιnteractιng protein 41

454556 AW807073 gb R4-ST0062-031199-018- 06 ST0062 Homo sapi 41

424834 AK001432 Hs 153408 Homo sapiens cDNA FU10570 fis, clone NT2RP20 41

412593 Y07558 Hs 74088 early growth response 3 41

416566 NM.003914 Hs 79378 cyclin A1 41

426342 AF093419 Hs 169378 multiple PDZ domain protein 41

428417 AK001699 Hs 184227 F-box only protein 21 41

429317 AA831552 Hs 268016 solute camerfamily 5 (inositol transporter 41

446880 AI811807 Hs 108646 Homo sapiens cDNA FU 12534 fis, clone NT2RM40 41

422988 AW673847 Hs 97321 ESTs 40

434657 AA641876 Hs 191840 ESTs 40

412494 AL133900 Hs 792 ADP-πbosylation factor domain protein 1, 64k 40

443271 BE568568 Hs 195704 ESTs 40

421437 AW821252 Hs 104336 ESTs 40

401644 0 40

405095 0 40

418417 R77182 gb yι65e02 r1 Soares placenta Nb2HP Homo sapi 40

420807 AA280627 Hs 57846 ESTs 40

429529 AA454190 Hs 193811 ESTs, Moderately similar to reduced expressio 40

457726 AI217477 Hs 194591 ESTs 40

431130 NM 006103 Hs 2719 epididymis-specific, whey-acidic protein type 40

453403 BE466639 Hs 61779 Homo sapiens cDNA FU13591 fis, clone PLACE10 40

442768 AL048534 Hs 48458 ESTs, Weakly similar to ALU8.HUMAN ALU SUBFAM 40

413430 R22479 Hs 24650 Homo sapiens cDNA FU13047 fis, clone NT2RP30 40

424081 NM 006413 Hs 139120 πbonuclease P (30kD) 40

425692 D90041 Hs 155956 NAT1, arylamine N-acetyltransferase 40

407792 AI077715 Hs 39384 putative secreted ligand homologous to fjxl 40

408353 BE439838 Hs 44298 hypothetical protein 40 421175 AI879099 Hs 102397 GIOT-3 for gonadotropin inducible franscπpti 39

420324 AF163474 Hs 96744 DKFZP586D0823 protein, Prostate androgen-regu 39

417531 NM 003157 Hs 1087 seπne/threonme kinase 2 39

458924 BE242158 Hs 24427 DKFZP56601646 protein 39

400195 0 39

401480 0 39

410360 AW663690 gb hj21g03 x1 NCI_CGAP_U8 Homo sapiens cDNA 39

410908 AA121686 Hs 10592 ESTs 39

420159 AI572490 Hs 99785 ESTs 39

422805 AA436989 Hs 121017 H2A histone family, member A 39

424639 AI917494 Hs 131329 ESTs 39

428555 NM.002214 Hs 184908 integπn, beta 8 39

431699 NM 001173 Hs 267831 Homo sapiens cDNA FU12952 fis, clone NT2RP20 39

433703 AA2Ϊ0863 Hs 3532 nemo-like kinase 39

437144 AL049466 Hs 7859 ESTs 39

452728 AI915676 Hs 239708 ESTs 39

430447 W17064 Hs 241451 SWI/SNF related, matπx associated, actin dep 39

440594 AW445167 Hs 126036 ESTs 39

408938 AA059013 Hs 22607 ESTs 39

427051 BE178110 Hs 173374 ESTs 39

447568 AF155655 Hs 18885 CGI-116 protein 39

457211 AW972565 Hs 32399 ESTs, Weakly similar to Similar to Ena-VASP I 39

443475 AI066470 Hs 134482 ESTs 39

433447 U29195 Hs 3281 neuronal pentraxin II 39

428093 AW594506 Hs 104830 ESTs 38

437938 AI950087 ESTs, Weakly similar to Gag-Pol polyprotein [ 38

408829 NM 006042 Hs 48384 heparan sulfate (glucosamine) 3-O-sulfotraπsf 38

429250 H56585 Hs 198308 tryptophan πch basic protein 38

441859 AW194364 Hs 128022 ESTs, Weakly similarto FIG1 MOUSE FIG-1 PROT 38

437700 AA766060 Hs 122848 ESTs 38

439560 BE565647 Hs 74899 hypothetical protein FLJ12820 38

409564 AA045857 Hs 54943 fracture callus 1 (rat) homolog 38

429474 AA453441 Hs 31511 ESTs 38

431965 BE175190 gb QV2-HT0577-010500 165-g04 HT0577 Homo sapi 38

454018 AW016892 Hs 241652 ESTs 38

426320 W47595 Hs 169300 transforming growth factor, beta 2 38

439635 AA477288 Hs 94891 Homo sapiens cDNA FLJ22729 fis, clone HSU 56 38

417517 AF001176 Hs 82238 POP4 (processing of precursor , S cerevisiae 38

446402 AI681145 Hs 160724 ESTs 38

450236 AW162998 Hs 24684 KIAA1376 protein 38

410804 U64820 Hs 66521 Machado-Joseph disease (sp ocerebellar ataxi 38

400268 0 38

418217 AI910647 Hs 13442 ESTs 38

421928 AF013758 Hs 109643 polyadenylate binding protein-interacting pro 38

417300 AI765227 Hs 55610 solute camerfamily 30 (zinc transporter), 38

414136 AA812434 Hs 178227 ESTs 38

453945 NM.005171 Hs 36908 activating transcπption factor 1 37

400240 0 37

407877 AW016811 Hs 234478 Homo sapiens cDNA FLJ22648 fis, clone HSI073 37

450581 AF081513 Hs 25195 endometπal bleeding associated factor (left 37

418223 NM 014733 Hs 83790 KIAA0305 gene product 37

411704 AI499220 Hs 71573 hypothetical protein FLJ 10074 37

432712 AB016247 Hs 288031 sterol-C5-desaturase (fungal ERG3, delta-5-de 37

422809 AK001379 Hs 121028 hypothetical protein FU 10549 37

402820 0 37

408090 BE173621 Hs 292478 ESTs 37

416421 AA134006 Hs 79306 eukaryotic translation initiation factor 4E 37

418282 AA215535 Hs 98133 ESTs 37

418454 AA315308 gb EST187095 Colon carcinoma (HCC) cell line 37

418668 AW407987 Hs 87150 Human clone A9A2BR11 (CAC)n/(GTG)n repeat-con 37

422290 AA495854 Hs 48827 hypothetical protein FLJ 12085 37

432824 AK001783 Hs 279012 hypothetical protein FLJ10921 37

439907 AA853978 Hs 124577 ESTs 37

447479 AB037834 Hs 18685 Homo sapiens mRNA for KIAA1413 protein, parti 37

451073 AI758905 Hs 206063 ESTs 37

450377 AB033091 Hs 24936 ESTs 37

414343 AL036166 Hs 75914 coated vesicle membrane protein 37

448807 AI571940 Hs 7549 ESTs 37

442821 BE391929 Hs 8752 Putative type II membrane protein 37

426300 U15979 Hs 169228 delta-like homolog (Drosophila) 37

418068 AW971155 Hs 293902 ESTs, Weakly similar to prolyl 4-hydroxylase 37

411263 BE297802 Hs 69360 kinesin-like 6 (mitotic centromere-associated 37

443054 AI745185 Hs 8939 yes-associated protein 65 kDa 37

421154 AA284333 Hs 287631 Homo sapiens cDNA FU14269 fis, clone PLACE10 37

411402 BE297855 Hs 69855 NRAS-related gene 37

450447 AF212223 Hs 25010 hypothetical protein P15-2 36

414706 AW340125 Hs 76989 KIAA0097 gene product 36

434228 Z42047 Hs 283978 ESTs, KIAA0738 gene product 36

434164 AW207019 Hs 148135 ESTs 36

409533 AW969543 Hs 21291 mitogen-activated protein kinase kinase kmas 36

402222 0 36

404915 0 36

404996 0 36

411560 AW851186 gb IL3-CT0220-150200-071-H05 CT0220 Homo sapi 36 419750 AL079741 Hs 183114 Homo sapiens cDNA FU14236 fis, clone NT2RP40 36

426010 AA136563 Hs 1975 Homo sapiens cDNA FU21007 fis, clone CAE038 36

427038 NM 014633 Hs 173288 KIAA0155 gene product 36

439255 BE164500 gb RC4-HT0469-230300-014-e10 HT0469 Homo sapi 36

458242 BE299588 Hs 28465 Homo sapiens cDNA FU21869 fis, clone HEP024 36

415115 AA214228 Hs 127751 hypothetical protein 36

453468 W00712 Hs 32990 DKFZP566F084 protein 36

441205 AW137827 Hs 176904 ESTs 36

452693 T79153 Hs 48589 zinc finger protein 228 36

417389 BE260964 Hs 82045 Midkme (neuπte growth promoting factor 2) 36

448105 AW591433 Hs 170675 ESTs, Weakly similar to TMS2.HUMAN TRANSMEMBR 36

451522 BE565817 Hs 26498 hypothetical protein FLJ21657 36

440048 AA897461 Hs 158469 ESTs, Weakly similar to envelope protein [H s 35

419359 AL043202 Hs 90073 chromosome segregation 1 (yeast homolog)-!ιke 35

452030 AL137578 Hs 27607 Homo sapiens mRNA, cDNA DKFZp564N2464 (from c 35

400666 0 35

422646 H87863 Hs 151380 ESTs 35

407846 AA426202 Hs 40403 Cbp/p300-ιnleractιng transactivator, with Glu 35

408730 AV660717 Hs 47144 DKFZP586N0819 protein 35

AMItf 0 35

413775 AW409934 Hs 75528 πucleolar GTPase 35

417177 NM.004458 Hs 81452 fatty-acid Coenzyme A ligase, long-chain 4 35

427943 AW959075 gb EST371145 MAGE resequences, MAGE Homo sapi 35

439107 AL046134 Hs 27895 ESTs 35

447268 AI370413 Hs 36563 Homo sapiens cDNA FU22418 fis, clone HRC085 35

412604 AW978324 Hs 47144 DKFZP586N0819 protein 35

427134 AA398409 Hs 173561 EST 35

430273 AI311127 Hs 125522 ESTs 35

436671 AW137159 Hs 146151 ESTs 35

433037 NM 014158 Hs 279938 HSPC067 protein 35

453745 AA952989 Hs 63908 Homo sapiens HSPC316 mRNA partial eds 35

400531 AF151064 Hs 36069 hypothetical protein 35

433345 AI681545 Hs 152982 EST cluster (not in UniGene) 34

406400 AA343629 Hs 104570 kallikrem 8 (neuropsin/ovasin) 34

407596 R86913 gb yq30f05 r1 Soares fetal liver spleen 1 FLS 34

453779 N35187 Hs 43388 ESTs 34

444858 AI199738 Hs 208275 ESTs, Weakly similar to unnamed protein produ 34

447688 N87079 Hs 19236 NADH dehydrogenase (ubiqumone) 1 belasubcom 34

424856 AA347746 Hs 9521 ESTs, Weakly similar to KIAA1015 protein [H s 34

407864 AF069291 Hs 40539 chromosome 8 open reading frame 1 34

404108 0 34

403729 0 34

404232 0 34

423687 AA329633 Hs 133011 ESTs, Highly similar to Z117.HUMAN ZINC FINGE 34

428372 AK000684 Hs 183887 hypothetical protein FU22104 34

439741 BE379646 Hs 6904 Homo sapiens mRNA full length insert cDNA do 34

441447 AA934077 Hs 126980 ESTs 34

448358 R44433 Hs 106614 Human DNA sequence from clone RP4-534K7 on ch 34

450926 AI744361 Hs 205591 ESTs, Weakly similar to zinc finger protein P 34

458477 NM 000314 Hs 10712 phosphatase and tensin homolog (mutated in mu 34

421379 Y15221 Hs 103982 small inducible cytokine subfamily B (Cys X-C 34

452822 X85689 Hs 288617 Homo sapiens cDNA FLJ22621 fis, clone HS1056 34

441111 AI806867 Hs 126594 ESTs 34

447519 U46258 Hs 23448 ESTs 34

446913 AA430650 Hs 16529 transmembrane 4 superfamily member (tetraspan 34

449581 AI989517 Hs 181605 ESTs 34

456132 BE219771 Hs 237146 Homo sapiens cDNA FU14234 fis, clone NT2RP40 34

448186 AA262105 Hs 4094 Homo sapiens cDNA FU 14208 fis, clone NT2RP30 34

422611 AA158177 Hs 118722 fucosyltransferase 8 (alpha (1,6) fucosyltran 34

441433 AA933809 Hs 42746 ESTs 34

417837 AL079905 Hs 1103 transforming growth factor, beta 1 34

450516 AA902656 Hs 21943 NIF3 (Ngg1 interacting factor 3, S pombe homo 34

407796 AA195509 Hs 272239 lymphocyte activation associated protein 33

419200 AW966405 Hs 288856 prefoldm 5 33

423161 AL049227 Hs 124776 Homo sapiens mRNA, cDNA DKFZp564N1116 (from c 33

445679 AI343868 Hs 58800 Homo sapiens cDNA FU12488 fis clone NT2RM20 33

435014 BE560888 Hs 10026 πbosomal protein L17 isolog 33

446619 AU076643 Hs 313 secreted phosphoprotein 1 (osteopontin, bone 33

439170 AA332365 Hs 165539 ESTs 33

429830 AI537278 Hs 225841 DKFZP434D193 protein 33

428943 AW086180 Hs 37636 ESTs, Weakly similar to KIAA1392 protein [H s 33

445817 NM 003642 Hs 13340 histone acetyltransferase 1 33

408805 H69912 Hs 48269 vaccinia related kinase 1 33

441134 W29092 Hs 7678 cellular retmoic acid binding protein 1 33

408532 AI453137 Hs 63176 ESTs 33

409517 X90780 Hs 54668 troponin I, cardiac 33

414304 AI621276 Hs 165998 DKFZP564M2423 protein 33

436427 AI344378 Hs 143399 ESTs 33

436662 AI582393 Hs 126695 ESTs 33

440304 BE159984 Hs 125395 ESTs 33

447385 F12863 gb HSC3FE081 normalized infant brain cDNA Horn 33

451177 AI969716 Hs 13034 ESTs 33

428949 AA442153 Hs 104744 ESTs, Weakly similar to AF2088551 BM 013 [H 33

451743 AW074266 Hs 23071 ESTs 33 421515 Y11339 Hs.105352 GalNAc alpha-2, 6-sialylfransferase I, long f 3.3

446351 AW444551 Hs.258532 ESTs 3.3

435102 AW899053 Hs.76917 F-box only protein 8 3.3

418216 AA662240 Hs.283099 AF15q14 protein 3.3

401508 0 3.3

437108 AA434054 Hs.80624 Homo sapiens cDNA: FU23442 fis, clone HSI009 3.3

416530 U62801 Hs.79361 kallikrein 6 (neurosiπ, zyme) 3.3

443171 BE281128 Hs.9030 TONDU 3.3

458627 AW088642 Hs.97984 ESTs; Weakly similar to WASP-family protein [ 3.3

412078 X69699 Hs.73149 paired box gene 8 3.3

414080 AA135257 Hs.47783 ESTs, Weakly similar to T12540 hypothetical p 3.3

401197 0 3.3

422134 AW179019 Hs.112110 ESTs 3.3

409044 AI129586 Hs.33033 ESTs 3.3

416198 H27332 Hs.99598 ESTs 3.2

436481 AA379597 Hs.5199 HSPC150 protein similarto ubiquitiπ-conjugat 3.2

436525 AA721428 Hs.26145 Homo sapiens cDNA FU14127 fis, clone MAMMA10 3.2

409142 AL136877 Hs.50758 chromosome-associated polypeptide C 3.2

428819 AL135623 Hs.193914 KIAA0575 gene product 3.2

428728 NM 016625 Hs.191381 ESTs; Weakly similar to hypothetical protein 3.2

421261 AA600853 Hs.98133 ESTs 3.2

446219 AI287344 Hs.149827 ESTs 3.2

457574 H88717 Hs.27774 ESTs, Highly similar to AF161349 1 HSPC086 [H 3.2

409172 Z99399 Hs.118145 ESTs 3.2

419388 T67012 Hs.75323 prohibitin „_t 3.2

434187 AA627098 Hs.99103 ESTs, Weakly similar to I38428 T-complex prot 3.2

445060 AA830811 Hs.88808 ESTs 3.2

448254 AI829900 Hs.22929 ESTs 3.2

452943 BE247449 Hs.31082 hypothetical protein FU 10525 3.2

411393 AW797437 Hs.69771 B-factor, properdin 3.2

453775 NM 002916 Hs.35120 replication factor C (activator 1) 4 (37kD) 3.2

408418 AW963897 Hs.44743 KIAA1435 protein 3.2

442025 AW887434 Hs.11810 ESTs, Weakly similar to CD4.2 [C.elegans] 3.2

417006 AW673606 Hs.80758 aspartyl-tRNA synthetase 3.2

407881 AW072003 Hs.40968 heparaπ sulfate (glucosamiπe) 3-O-sulfotraπsf 3.2

444755 AA431791 Hs.183001 ESTs 3.2

402829 0 3.2

451593 AF151879 Hs.26706 CGI-121 protein 3.2

419926 AW900992 Hs.93796 DKFZP586D2223 protein 3.2

434551 BE387162 Hs.280858 ESTs, Highly similar to XPB.HUMAN DNA-REPAIR 3.2

445929 AI089660 Hs.7838 makorin, ring finger protein, 1 3.2

409365 AA702376 Hs.226440 Homo sapiens clone 24881 mRNA sequence 3.2

418836 AI655499 Hs.161712 ESTs 3.2

441020 W79283 Hs.35962 ESTs 3.1

422363 T55979 Hs.115474 replication factor C (activator 1) 3 (38kD) 3.1

413010 AA393273 Hs.75133 transcription factor 6-like 1 (mitochondrial 3.1

452092 BE245374 Hs.27842 hypothetical protein FLJ11210 3.1

410486 AW235094 Hs.193424 ESTs, Weakly similar to KIAA1064 protein [H.s 3.1

434540 NM 016045 Hs.5184 TH1 drosophila homolog 3.1

409178 BE393948 Hs.50915 kallikrein 5 3.1

439480 AL038511 Hs.125316 ESTs 3.1

417848 AA206581 Hs.39457 ESTs 3.1

446293 AI420213 Hs.149722 ESTs 3.1

408108 AI580492 Hs.42743 hypothetical protein 3.1

415947 U04045 Hs.78934 mutS (E. coli) homolog 2 (colon cancer, nonpo 3.1

410519 AW612264 Hs.131705 ESTs 3.1

421987 AI133161 Hs.286131 CGI-101 protein 3.1

440046 AW402306 Hs.6877 hypothetical protein FLJ 10483 3.1

453931 AL121278 Hs.25144 ESTs 3.1

454423 AW603985 Hs.179662 nucleosome assembly protein 1-like 1 3.1

459089 F13036 Hs.27373 Homo sapiens mRNA; cDNA DKFZp56401763 (from c 3.1

418735 N48769 Hs.44609 ESTs 3.1

414245 BE148072 Hs.75850 WAS protein family, member 1 3.1

410909 AW898161 Hs.53112 ESTs, Weakly similar to ALU8.HUMAN ALU SUBFAM 3.1

434926 BE543269 Hs.50252 Homo sapiens HSPC283 mRNA, partial eds 3.1

409239 AA740875 Hs.44307 ESTs 3.1

429017 AA463605 Hs.238995 ESTs 3.1

447072 D61594 Hs.17279 tyrosylprotein sulfofransferase 1 3.1

426514 BE616633 Hs.301122 bone morphogenetic protein 7 (osteogenic prot 3.1

448133 AA723157 Hs.73769 folate receptor 1 (adult) 3.1

418792 AB037805 Hs.88442 KIAA1384 protein 3.1

427528 AU077143 Hs.179565 minichromosome maintenance deficient (S. cere 3.1

402077 0 3.1

440671 AW297920 Hs.130054 ESTs 3.1

419890 X17360 Hs.278255 homeo box D4 3.1

406687 M31126 Hs.272620 pregnancy specific beta-1-glycoprotein 9 3.1

409151 AA306105 Hs.50785 SEC22, vesicle trafficking protein (S. cerevi 3.1

431221 AA449015 Hs.286145 SRB7 (suppressor of RNA polymerase B; yeast) 3.1

443584 AI807036 Hs.1016 9 ESTs 3.1

445525 BE149866 Hs.14831 ESTs 3.1

410441 BE298210 gb:601118016F1 NIH.MGC.17 Homo sapiens cDNA c 3.1

422634 NM 016010 Hs.118821 CGl-62 protein 3.0

420022 AA256253 Hs.120817 ESTs 3.0

453912 AL121031 Hs.32556 KIAA0379 protein 3.0 456844 A1264155 Hs.152981 CDP-diacylglycerol synthase (phosphatidate cy 3.0

414941 C14865 Hs.182159 ESTs 3.0

407807 AL031427 Hs.40094 Human DNA sequence from clone 167A19 on chrom 3.0

414725 AA769791 Hs.120355 Homo sapiens cDNA FU13148 fis, clone NT2RP30 3.0

444420 AI148157 Hs.146766 ESTs 3.0

431742 NM.016652 Hs.268281 CGI-201 protein 3.0

412519 AA196241 Hs.73980 fropoπiπ T1, skeletal, slow 3.0

418348 AI537167 Hs.96322 Homo sapiens cDNA: FU23560 fis, clone LNG098 3.0

444261 AA298958 Hs.10724 MDS023 protein 3.0

457465 AW301344 Hs.195969 ESTs 3.0

443933 AI091631 Hs.135501 Homo sapiens two pore potassium channel KT3.3 3.0

442150 AI368158 Hs.128864 ESTs 3.0

414883 AA926960 Hs.77550 CDC28 protein kinase 1 3.0

442879 AF032922 Hs.8813 syntaxin binding protein 3 3.0

437949 U78519 Hs.41654 ESTs 3.0

403515 0 3.0

403864 0 3.0

407785 AW207285 Hs.98279 ESTs 3.0

426199 AA371865 Hs.97090 ESTs 3.0

426324 AW291787 Hs.200933 ESTs 3.0

427738 NM.000318 Hs.180612 peroxisomal membrane protein 3 (35kD, Zellweg 3.0

427837 U87309 Hs.180941 vacuolar protein sorting 41 (yeast homolog) 3.0

439430 AF124250 Hs.6564 breast cancer anti-estrogen resistance 3 3.0

442039 AW276240 Hs.128352 ESTs, Weakly similarto p80 [R.norvegicus] 3.0

446978 NM.001938 Hs.16697 down-regulator of transcription 1 , TBP-bindin 3.0

452431 U88879 Hs.29499 toll-like receptor 3 3.0

452841 T17431 Hs.65412 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3.0

432114 AL036021 Hs.225597 ESTs 3.0

445640 AW969626 Hs.31704 ESTs, Weakly similar to KIAA0227 [H.sapiens] 3.0

442607 AA507576 Hs.288361 KIAA0741 gene product 3.0

453920 AI133148 Hs.36602 I factor (complement) 3.0

430000 AW205931 Hs.99598 ESTs 3.0

429164 AI688663 Hs.116586 ESTs 3.0

453331 AI240665 Hs.8895 ESTs 3.0

448663 BE614599 Hs.106823 H.sapiens gene from PAC 426I6, similar to syπ 3.0

425776 U25128 Hs.159499 parathyroid hormone receptor 2 3.0

401714 0 3.0

400903 0 3.0

428428 AL037544 Hs.184298 cyclin-dependeπt kinase 7 (homolog of Xenopus 3.0

443761 AI525743 Hs.160603 ESTs 3.0

451640 AA195601 Hs.26771 Human DNA sequence from clone 747H23 on chrom 3.0

442580 AI733682 Hs.130239 ESTs 3.0

TABLE 10B: Pkey: Unique Eos probeset identifier number

CAT number: Gene cluster number Accession: Genbank accession numbers

Pkey CAT Number Accession

407596 1003489 1 R86913 R86901 H25352 R01370 H43764 AW044451 W21298

409763 115392.1 AL043212 AA077575 AA077655 R19502 BE545457 AI638421 R14093

410360 1197225 -2 AW663690

410441 120358.1 BE298210 AI672315 AW086489 BE298417 AA455921 AA902537 BE327124 R14963 AA085210 AW274273 AI333584 AI369742 AI039658

AI885095 AI476470 AI287650 AI885299 AI985381 AW592624 AW340136 AI266556 AA456390 AI310815 AA484951

411560 1249443 1 AW851186 AW996967 BE143456

414315 143512 1 Z24878 AA494098 F13654 AA494040 AA143127

418417 1750818 1 R77182 R77197 R80484

418454 175699 1 AA315308 AA223392 BE538098 BE087173

419346 184129 1 AI830417 AA236612

424770 243504 1 AA425562 AI880208 AA346646 N22655 AW811775 AW811786

427943 284802 1 AW959075 W06838AA417863

431965 33959 2 BE175190 BE003348

436812 427323 1 AW298067AA731645 AA810101 AW194180AI690673 AW978773

437938 44573 2 AI950087 N70208 R97040 N36809 A1308119 AW967677 N35320 AI251473 H59397 AW971573 R97278 W01059 AW967671 AA908598

AA251875 AI820501 AI820532 87891 T85904 U71456T82391 BE328571 T75102 R34725 AA884922 BE328517 AI219788 AA884444

N92578 F13493 AA927794 AI560251 AW874068 AL134043 AW235363 AA663345 AW008282 AA488964 AA283144 AI890387 AI950344

AI741346 AI689062 AA282915 AW102898 A1872193 AI763273 AW173586 AW150329 AI653832 AI762688 AA988777 AA488892 AI356394

AW103813 AI539642 AA642789 AA856975 AW505512 AI961530 AW629970 BE612881 AW276997 AW513601 AW512843 AA044209

AW856538 AA180009 AA337499 AW961101 AA251669 AA251874 AI819225 AW205862 AI683338 AI858509 AW276905 AI633006 AA972584

AA908741 AW072629 AW513996 AA293273 AA969759 N75628 N22388 H84729 H60052 T92487 AI022058 AA780419 AA551005 W80701

AW613456 AI373032 AI564269 F00531 H83488 W37181 W78802 R66056 AI002839 R67840 AA300207 AW959581 T63226 F04005

439255 4703211 BE164500 AA832198 BE164502 447385 719912.1 F12863 AI377223 T75099 454193 1050256.1 BE141183 AW178167 AW178162 AW178166 AW178172 AW845893 AW178159 AW178222 AW178213 AW178215 AW178090 AW178091

AW178161 AW178207AW178210 AW178214 AW178212 BE140918 BE140917AW178135AW178205 AW178209 AW178223 AW178220

AW178206 AW178203 AW178165 AW178168 AW178160 AW178136 AW845878 AW178131 AW178138 AW178105 AW845894 AW178129

AW845810 AW845828 AW178216AW178112AW178211 AW178224 BE140915 AW178221 AW178130 AW178134AW178096 AW178108

AW178133 AW178164AW178218AW178171 AW178157AW178158 AW178103 BE141189 AW178170 AW845816 BE141586 AW178156

AW178104 AW178163 AW178093 AW178208 AW178137 AW178140 AW178219 BE141592 AW845901 BE141580 AW178155 BE141598

BE140957

454556 1223878.1 AW807073 AW807055 AW807067 AW807276 AW807030 AW807363 AW845892 AW807091 AW807275 AW807284 AW807287 AW845891

AW807195 AW807271 454933 1245515.1 BE141714 AW845993 AW845989 TABLE 10C

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham I et al " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489495 Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons

Pkey Ref Strand NLposition

400534 6981826 Minus 278637-279292

400666 8118496 Plus 17982-18115,20297-20456

400903 2911732 Plus 59112-59228

401197 9719705 Plus 176341-176452

401480 7321503 Plus 166120-166347,166451-166557,169651-169832

401508 7534110 Minus 110779-110983

401517 7677912 Plus 29278-29770

401644 8576138 Plus 82655-83959

401714 6715702 Plus 96484-96681

402077 8117414 Plus 65014-65195

402222 9958106 Plus 3261-3834,39394269

402408 9796239 Minus 110326-110491

402820 6456853 Minus 82274-82443

402829 8918414 Plus 101532-101852,102006-102263

403381 9438267 Minus 26009-26178

403515 7656757 Minus 173358-179553

403729 7543752 Minus 37662-37909₁

403864 7709019 Minus 51753-51890,79290-79445

404108 8247074 Minus 63603-64942

404232 8218045 Minus 71800-71956

404552 7243881 Plus 19854-20010

404567 7249169 Minus 101320-101501

404599 8705107 Plus 110443-110733

404915 7341766 Minus 100915-101087

404996 6007890 Plus 37999-38145,38652-38998,39727-39872,4055740674,42351 42450

405095 8072599 Plus 138877-139066

406069 9117732 Plus 68880-69374

406117 9142932 Plus 54304-54584

Table 11 A lists about 222 genes up regulated in ovanan cancer compared to normal adult tissues that are likely to encode extracellular or cell-surface proteins These were selected as for Table 10A, except that the ratio was greater than or equal to 20, and the predicted protein contained a structural domain that is indicative of extracellular localization (e g ig, fn3, egf, 7tm domains, signal sequences, transmembrane domains) Predicted protein domains are noted

TABLE 11 A ABOUT 222 UP-REGULATED GENES ENCODING EXTRACELLULAR/CELL SURFACE PROTEINS, OVARIAN CANCER VERSUS NORMAL ADULT TISSUES

Pkey Pπmekey

Ex Accn Exemplar Accession

UG ID UniGeπe lD

Title UmGene title

PFAM domains predicted protein structural domains ratio ratio tumor vs normal tissue

Pkey Ex Accn UG ID Title PFAM domains ratio

400292 AA250737 Hs 72472 BMPR-lb, bone morphogenetic pro pkinase.Activm.recp 300

400289 X07820 Hs 2258 Matnx Metalloprotemase 10 (Strom SS.hemopexm.Peptidas 25 2

427585 D31152 Hs 179729 collagen, type X, alpha 1 (Schmid C1q,Collagen 227

436982 AB018305 Hs 5378 spondin 1, (f-spondm) extracellular m tsp 1 190

428579 NM.005756 Hs 184942 G protein-coupled receptor 64 TM 174

443646 AI085198 Hs 298699 ESTs TSPN,vwc,tsp 1.EGF 15 1

436209 AW850417 Hs 254020 ESTs, Moderately similar to uπname TM 141

418601 AA279490 Hs 86368 calmegin SS.calreticuliπ 13 8

428532 AF157326 Hs 184786 TBP-mteracting protein TM 13 6

427344 NM 000869 Hs 2142 5-hydroxytryptamιne (serotonin) rec TM.neur.chan 11 8

432677 NM.004482 Hs 278611 UDP-N-acetyl-alpha-D-galactosamiπ TM.GIycos transf 2,Rι 11 0

404567 NM 015902 Hs 278428 progestm induced protein (DD5) TM,HECT,zf-UBR1 108

445537 AJ245671 Hs 12844 EGF-like-domam, multiple 6 SS.MAM EGF 89

409928 AL137163 Hs 57549 hypothetical protein dJ473B4 TM.MSP domain 88

407001 U12471 Hs 247954 Human thrombospondιn-1 gene, par TSPN,vwc,tsp_1,EGF 85

453370 AI470523 Hs 182356 ESTs, Moderately similar to translat ABC tran ABC.membr 84

400298 AA032279 Hs 61635 STEAP1 TM 81

431725 X65724 Hs 2839 Nome disease (pseudoglioma) SS.Cys knot 79

429609 AF002246 Hs 210863 cell adhesion molecule with homolo TM,fn3,ιg 78

412170 D16532 Hs 73729 very low density lipoprotein recepto TM,ldl_recept_a,ldl_rec 74

428954 AF100781 Hs 194678 WNT1 inducible signaling pathway SS,IGFBP,Cys_knot,tsp 74

418007 M13509 Hs 83169 Matπx metalloprotease 1 (mterstitia SS.hemopexm.Peptidas 72

424001 W67883 Hs 137476 KIAA1051 protein Pep M12B_propep,Rep 72

456965 AW131888 Hs 172792 ESTs, Weakly similar to hypothetica TM 7 1

446142 AI754693 Hs 145968 ESTs Cadheπn.C.term.cadhe 70

415138 C18356 Hs 78045 tissue factor pathway inhibitor 2 TFP Kunitz BPTI.G-gamma 68

438167 R28363 Hs 24286 ESTs 7tm_1 66

452097 AB002364 Hs 27916 ADAM-TS3 , a dismtegπn like and Pep M12B prapep.Rep 64

449048 Z45051 Hs 22920 similarto S68401 (cattle) glucose in SS 58

425371 D49441 Hs 155981 mesothelin SS 57

407945 X69208 Hs 606 ATPase, Cu++ transporting, alpha p TM,E1-E2_ATPase,Hy 56

424620 AA101043 Hs 151254 kallikrein 7 (chymotryptic, stratum c SS.trypsm 55

420362 U79734 Hs 97206 huπtingtin interacting protein 1 TM,ENTH,I_LWEQ 54 413384 NM 000401 Hs 75334 exostoses (multiple) 2 TM 53

425154 NM 001851 Hs 154850 collagen, type IX, alpha 1 Collagen.TSPN 52

411945 AL033527 Hs 92137 v-myc avian myelocytomatosis viral TGF-beta,TGFb_propep 51

415539 AI733881 Hs 72472 BMPR-lb, bone morphogenetic pro pkmase.Activin.recp 5 1

438018 AK001160 Hs 5999 hypothetical protein FU 10298 TM 49

424539 L02911 Hs 150402 activin A receptor, type I Activm.recp pkmase 48

450375 AA009647 Hs 8850 a disintegπn and metalloproteinase d disintegπn, Reprolysin.P 47

451684 AF216751 Hs 26813 CDA14 TM 46

400296 AA305627 Hs 139336 ATP-binding cassette, sub-family C TM.ABC tran.ABC.m 46

429597 NM 003816 Hs 2442 a disintegπn and metalloproteinase d TM 45

400534 AP000541 predicted exons TM,KRAB,zf-C2H2 45

425506 NM 003666 Hs 158205 basic leucine zipper nuclear factor 1 TM.Folate carrier 45

413472 BE242870 Hs 75379 solute camerfamily 1 (glial high aff TM.SDF 44

449535 W15267 Hs 23672 low density lipoprotein receptor rela SS,ldl_recept_b,tdl_rece 44

452028 AK001859 Hs 27595 hypothetical protein FU 10997 Zn carbOpeplPropep M 43

418693 AI750878 Hs 87409 thrombospondin 1 EGF,TSPN,tsp_1,tsp 3, 43

410361 BE391804 Hs 62661 guanylate binding protein 1, mterfer TM.GBP 42

407872 AB039723 Hs 40735 frizzled (Drosophila) homolog 3 Fnzzled,Fz,7tm_2 42

421502 AF111856 Hs 105039 solute camerfamily 34 (sodium pho TM.Na Pι_cofrans 42

412494 AL133900 Hs 792 ADP-πbosylation factor domain pro arf,zf-B_box,zf-C3HC4 40

405095 NM.014479 Hs 145296 disintegπn protease Reprolysm.disintegππ 40

431130 NM 006103 Hs 2719 epididymis-specific, whey-acidic pro SS.wap 40

407792 AI077715 Hs 39384 putative secreted ligand homologous SS 40

408829 NM 006042 Hs 48384 heparan sulfate (glucosamine) 3-O-s TM 38

450581 AF081513 Hs 25195 endometπaljjleeding associated fact SS,TGF-beta,TGFb_pro 37

432712 AB016247 Hs 288031 sterol-C5-desaturase (fungal ERG3, TM.Sterol.desat 37

450447 AF212223 Hs 25010 hypothetical protein P15-2 TM.ANF receptor.guan 36

414706 AW340125 Hs 76989 KIAA0097 gene product TM 36

417389 BE260964 Hs 82045 Midkiπe (neuπte growth-promoting TM.PTN.MK 36

400666 X07820 Hs 2258 Matπx Metalloprotemase 10 (Strom SS.hemopexm.Peptidas 35

406400 AA343629 Hs 104570 kallikrein 8 (neuropsin/ovasm) SS.frypsiπ 34

407864 AF069291 Hs 40539 chromosome 8 open reading frame 1 TM,FHA,BRCT 34

452822 X85689 Hs 288617 Homo sapiens cDNA FU22621 fis, EGF,fn3,pkιnase 34

446913 AA430650 Hs 16529 transmembrane 4 superfamily memb TM,transmembrane4 34

422611 AA158177 Hs 118722 fucosyltransferase 8 (alpha (1,6) fuc SS 34

423161 AL049227 Hs 124776 Homo sapiens mRNA, cDNA DKFZ cadheπn.Cadheππ C te 33

435102 AW899053 Hs 76917 F-box only protein 8 TM,Sec7 33

416530 U62801 Hs 79361 kallikrein 6 (neurosm, zyme) SS M.trypsin 33

401197 predicted exons arf.Ets 33

436525 AA721428 Hs 26145 Homo sapiens cDNA FLJ14127 fis, TM 32

452943 BE247449 Hs 31082 hypothetical protein FU 10525 TM 32

411393 AW797437 Hs 69771 B-factor, properdin SS,sushι,trypsιn,vwa fib 32

407881 AW072003 Hs 40968 heparan sulfate (glucosamine) 3-O-s SS 32

418836 AI655499 Hs 161712 ESTs pkmase.Activin.recp 32

409178 BE393948 Hs 50915 kallikrein 5 SS.frypsin 3 1

421987 AI133161 Hs 286131 CGI-101 protein TM 3 1

447072 D61594 Hs 17279 tyrosylproteiπ sulfofransferase 1 SS 3 1

426514 BE616633 Hs 301122 bone morphogenetic protein 7 (osteo SS.TGFb propeptide.T 3 1

448133 AA723157 Hs 73769 folate receptor 1 (adult) TM 3 1

406687 M31126 Hs 272620 pregnancy specific beta-1-glycoprat SS,Peptιdase_M10 hem 31

456844 AI264155 Hs 152981 CDP-diacylglyceral synthase (phosp TM.Cytidylyltrans 30

414725 AA769791 Hs 120355 Homo sapiens cDNA FU13148 fis, SPRY,7tm_1 30

407785 AW207285 Hs 98279 ESTs Sema.ig 30

427738 NM 000318 Hs 180612 peroxisomal membrane protein 3 (35 TM,zf-C3HC4 30

452431 U88879 Hs 29499 toll like receptor 3 TM,TIR,LRRCT 30

453920 AI133148 Hs 36602 I factor (complement) ldl_recepLa,trypsιn,SRC 30

453331 AI240665 Hs 8895 ESTs disintegπn.Reprolysm.P 30

425776 U25128 Hs 159499 parathyroid hormone receptor 2 TM,7tm_2 30

428428 AL037544 Hs 184298 cyclin-dependent kinase 7 (homolog TM.pkmase 30

407910 AA650274 Hs 41296 fibronectin leucine nch transmembra TM,LRRCT,LRRNT,LR 29

408380 AF123050 Hs 44532 diubiquitin TM,Ubιquιtιn,7tm_3,AN 29

407783 AW996872 Hs 172028 a disintegπn and metalloprotemase d disintegπn.Reprolysin 29

420757 X78592 Hs 99915 androgen receptor (dihydrotestostero TM,Androgen_recep,ho 29

424406 D54120 Hs 146409 wingless-type MMTV integration sit cadheπn.Cadheπn C te 29

428549 AA430064 Hs 220929 ESTs, Moderately similar to ARF-fa arf 29

419452 U33635 Hs 90572 PTK7 protein tyrosine kinase 7 TM,pkιnase,ιg 29

452281 T93500 Hs 28792 ESTs TGFb_propeptιde,TGF- 29

420440 NM 002407 Hs 97644 mammaglobin 2 SS.Uteraglobin 29

418848 AI820961 Hs 193465 ESTs pkmase.Activin.recp 29

421991 NM 014918 Hs 110488 KIAA0990 protein SS 29

433190 M26901 Hs 3210 renm SS.asp 29

424538 NM 005095 Hs 150390 zinc finger protein 262 TM 28

433002 AF048730 Hs 279906 cyclin T1 SS 28

444342 NM 014398 Hs 10887 similar to lysosome-associated mem TM.Lamp 28

430598 AK001764 Hs 247112 hypothetical protein FU 10902 TM 28

428450 NM 014791 Hs 184339 KIAA0175 gene product TM,pkιnase,KA1 28

450171 AL133661 Hs 24583 hypothetical protein DKFZp434C03 TM 28

423554 M90516 Hs 1674 glutamιne-fructose-6-phosphate tran TM,GATase_2,SIS 28

430016 NM.004736 Hs 227656 xenotropic and polytropic retrovirus TM 28

417866 AW067903 Hs 82772 collagen, type XI, alpha 1 Collageπ.COLFIJSPN 28

424894 H83520 Hs 153678 reproduction 8 SS.UBX 28

430651 AA961694 Hs 105187 kinesm protein 9 gene SS 27

414853 U31116 Hs 77501 sarcoglycan, beta (43kD dystrophin- TM 27

448595 AB014544 Hs 21572 KIAA0644 gene product TM.LRRCT.LRR 27 452835 AK001269 Hs 30738 ESTs TM 27

403019 AA834626 Hs 66718 RAD54 (S cerevιsιae)-lιke SS,Antι_prolιferat 27

420281 AI623693 Hs 191533 ESTs Cation.efflux 27

434815 AF155582 Hs 46744 coral UDP-galactose N-acetylgalact SS 26

432201 AI538613 Hs 135657 TMPRSS3a mRNA for seπne protea frefoil.frypsin 26

430450 R23553 Hs 241489 hypothetical protein SS 26

448402 BE244226 Hs 21094 RAB18, member RAS oncogene fam ras.arf 26

421802 BE261458 Hs 108408 CGI-78 protein TM 26

452355 N54926 Hs 29202 G protein-coupled receptor 34 TM,7tm_1 26

417742 R64719 gb EST22d11 WATM1 Homo sapie aπk,death,RHD,TIG 26

451346 NM 006338 Hs 26312 glioma amplified on chromosome 1 TM,ιg,LRR,LRRNT,LR 26

433147 AF091434 Hs 43080 platelet deπved growth factor C TM,PDGF,CUB 26

420079 NM.014051 Hs 94896 PTD011 protein SS.TM, 26

419918 X80700 Hs 93728 pre-B-cell leukemia transcπption fac homeobox,ιg,Acyltransf 25

432350 NM_005865 Hs 274407 protease, seπne, 16 (thymus) SS 25

406671 AA129547 Hs 285754 met proto-oncogene (hepatocyte gro pkmase,Sema,Plexιn_re 25

417412 X16896 Hs 82112 interieukm 1 receptor, type I SS,TIR,ιg 25

422530 AW972300 Hs 118110 bone marrow stromal cell antigen 2 TM 25

433929 AI375499 Hs 27379 ESTs EGF,ldLrecept_a,ldl_re 25

443562 AF118838 Hs 9599 solute camerfamily 25, member 13 TM.mito.carr 25

414386 X00442 Hs 75990 haptoglobin sushi.trypsin 25

417576 AA339449 Hs 82285 phosphoπbosylglyciπamide formyltr AlRS,formyl_transf,GA 25

449207 AL044222 Hs 23255 nucleopoπn 155kD TM 25

416107 AA173846 Hs 79015 antigen identified by monoclonal ant TM,ιg 24

421750 AK000768 Hs 107872 hypotheticaljrotein FLJ20761 TM.PH 24

414812 X72755 Hs 77367 monokiπe induced by gamma inierfe SS.IL8 24

406137 R42764 Hs 3248 mutS (E coli) homolog 6 TM,MutS CMutS N,P 24

450710 AW953381 Hs 18627 ESTs, Weakly similar to G01447 GP TM 24

430291 AV660345 Hs 238126 CGI-49 protein TM 2.4

425184 BE278288 Hs 155048 Lutheran blood group (Auberger b a ig 24

451418 BE387790 Hs 26369 ESTs TM 24

412277 BE277592 Hs 73799 guanine nucleotide binding protein ( TM,G-alpha 24

413719 BE439580 Hs 75498 small inducible cytokine subfamily A SS.IL8 24

451806 NM 003729 Hs 27076 RNA 3'-termιnal phosphate cyclase TM.RCT 23

416224 NM.002902 Hs 79088 reticulocalbm 2, EF-hand calcium bi SS.efhand 23

452268 NM.003512 Hs 28777 H2A histone family, member L histone.Calc CGRP IA4 23

451668 Z43948 Hs 26789 ASPIC (acidic secreted protein in ca SS.TM, 23

400880 M84349 Hs 119663 CD59 antigen SS.UPAR.LY6 23

421340 F07783 Hs 1369 decay accelerating factor for comple SS.sushi 23

443986 AI381750 Hs 283437 HTGN29 protein TM 23

443037 AW500305 Hs 8906 syntaxin 7 TM.Syntaxin 23

440516 S42303 Hs 161 cadheπn 2, type 1, N-cadhenn (neur HNH.cadhenn.Cadheπn 23

404877 AI394145 Hs 18048 melanoma antigen MAGE-10 TM.MAGE 23

440704 M69241 Hs 162 insulin-like growth factor binding pr SS.thyroglobulm 1.IGF 23

437952 D63209 Hs 5944 solute earner family 11 (proton-coup TM 23

418624 AI734080 Hs 104211 ESTs Sema.ig 22

410434 AF051152 Hs 63668 toll like receptor 2 SS,TIR,LRRCT,LRR 22

424687 J05070 Hs 151738 matπx metalloprotemase 9 (gelatma SS,fn2,hemopexιπ,Peptι 22

431457 NM 012211 Hs 256297 integπn, alpha 11 TM,FG-GAP,vwa 22

407907 AI752235 Hs 41270 procollagen-lysine, 2-oxoglutarate 5 SS.Lysyl ydro 22

400898 AF220030 Hs 125300 Homo sapiens fripartite motif protein SPRY,7tm_1 22

400303 AA242758 Hs 79136 Human breast cancer, estrogen regul SS.TM, 22

411789 AF245505 Hs 72157 Homo sapiens mRNA, cDNA DKFZ ig.LRRCT 22

414809 AI434699 Hs 77356 transferπn receptor (p90, CD71) TM,PA,Rιbosoma) S2 22

401131 NMJ01651 Hs 298023 Homo sapiens aquaporin 5 (AQP5), TM.MIP 22

400277 Y00281 Hs 2280 Human mRNA for πbophoπn I TM 2 1

409317 U20165 Hs 53250 bone morphogenetic protein recepto TM.pkinase 21

409956 AW103364 Hs 727 H sapiens activin beta-A subunit (ex TGF-beta,TGFb propep 2 1

451253 H48299 Hs 26126 daudin 10 TM,PMP22_Claudιn 2 1

429638 AI916662 Hs 211577 Kiπectin 1 (kiπesin receptor) TM 21

409267 NM 012453 Hs 52515 fransduciπ (beta)-lιke 2 TM.WD40 21

418414 J04977 Hs 84981 X-ray repair complementing defect™ SS 21

449057 AB037784 Hs 22941 ESTs TM 21

417666 AI345001 Hs 82380 menage a trois 1 (CAK assembly fac zf-C3HC4 2 1

428485 NM.002950 Hs 2280 πbophoπn I TM 21

445798 NM 012421 Hs 13321 rearranged L-myo fusion sequence TM,zf-C2H2 2 1

430057 AW450303 Hs 2534 bone morphogenetic protein recepto TM,Actιvιn_recp,pkιna 2 1

425189 H16622 gb ym26c07 r1 Soares infant brain 1 RasGEF.PH.fibπnogeπ. 2 1

413063 AL035737 Hs 75184 chitmase 3-lιke 1 (cartilage glycopro SS.GIyco hydro 18 2 1

421343 BE246444 Hs 283685 hypothetical protein FU20396 TM 2 1

425627 AF019612 Hs 297007 ESTs TM.Peptidase M50 21

426261 AW242243 Hs 168670 peroxisomal farnesylated protein E1-E2 ATPase,Catιon 21

431638 NM.000916 Hs 2820 oxytocm receptor TM,7tm_1 21

456546 AI690321 Hs 203845 ESTs, Weakly similar to TWIK-rela TM 21

421685 AF189723 Hs 106778 calcium transport ATPase ATP2C1 TM,E1-E2_ATPase,Hy 21

424099 AF071202 Hs 139336 ATP-binding cassette, sub-family C TM ABC tran.ABC m 21

424800 AL035588 Hs 153203 MyoD family inhibitor TM 21

410007 AW950887 Hs 57813 zinc πbboπ domain containing, 1 TFIIS 21

436135 D85390 Hs 5057 carboxypeptidase D SS.Zn.carbOpept 21

420633 NM 014581 Hs 99526 odorant-biπding protein 2B TM.Iipocalm 21

420162 BE378432 Hs 95577 cyclm-dependent kinase 4 pkιnase,ank,ArfGap,PH 21

426156 BE244537 Hs 167382 natnuretic peptide receptor A/guany TM,ANF_receptor,guan 20

442711 AF151073 Hs 8645 hypothetical protein TM 20

411872 AW327356 Hs 90918 chromosome 11 open reading frame TM 20 427801 AW979155 Hs 234433 hypothetical protein PRO1068 TMAa trans 20

430268 AK000737 Hs 237480 hypothetical protein FU20730 TM 20

431183 NM.006855 Hs 250696 KDEL (Lys-Asp-Glu-Leu) endoplas TM.ER.Iumen.recept.l 20

431846 BE019924 Hs 271580 Uraplakin 1B TM,fraπsmembrane4 20

404210 U02478 Hs 100469 Human AF-6 mRNA TM,RA,DIL,PDZ,FHA 20

435640 AF220053 Hs 54960 uπcharacteπzed hematopoietic stem/ TM,SET,zf-CXXC,PHD 20

447906 AL050062 Hs 19999 DKFZP566K023 protein SS 20

412666 AL080116 Hs 74420 oπgm recognition complex, subunit TM 20

417181 L10123 Hs 1071 surfactant protein A binding protein TM 20

423945 AA410943 Hs 72472 BMPR-lb, bone morphogenetic pro TM,pkιnase,Aciιvm_rec 20

411773 NM.006799 Hs 72026 protease, seπne, 21 (testism) SS.trypsin 20

448350 L14561 Hs 78546 Homo sapiens clone 24411 mRNA s TM.E1-E2 ATPase,Hy 20

401093 AI955244 Hs 121520 HYPOTHETICAL 164 kDa PROTE TM.LRRCT 20

415664 NM 004939 Hs 78580 DEAD/H (Asp-Glu-Ala-Asp/His) bo DEAD.helicase.CSPRY 20

448165 NM.005591 Hs 202379 meiotic recombination (S cerevisiae DNA_repaιr,Glyco_tran 20

416391 AI878927 Hs 79284 mesoderm specific transcπpt (mouse TM.abhydrolase 20

422926 NM.016102 Hs 121748 πng finger protein 16 SPRY,zf-C3HC4,zf-B 20

446849 AU076617 Hs 16251 cleavage and polyadenylation specif TM 20

427617 D42063 Hs 179825 RAN binding protein 2-lιke 1 TM,Ran_BP1,zf-RanBP 20

411678 A1907114 Hs 71465 squalene epoxidase TM.Monooxygenase 20

432554 AI479813 Hs 278411 NCK-associated protein 1 TM 20

TABLE 11B

Pkey Unique Eos probeset identifier number CAT number Gene cluster number Accession Genbank accession numbers

Pkey CAT Number Accession

417742 1696282.1 R64719 Z44680 R12451

425189 247825.1 H16622 R17322 AA351959

TABLE 11C

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source Tne 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham I et al " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489495

Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons

Pkey Ref Strand NLposition

400534 6981826 Minus 278637-279292

401197 9719705 Plus 176341-176452

Table 12A lists about 57 genes up-regulated in ovarian cancer compared to normal adult tissues that are likely to encode either enzymes or proteins amenable to modulation by small molecules These were selected as for Table 10A, except that the ratio was greater than or equal to 20, and the predicted protein contained a structural domain that is indicative of enzymatic function or of being modulated by small molecules (e g , pkmase, peptidase, isomerase, transporters) Predicted protein domains are noted

TABLE 12A ABOUT 57 UP-REGULATED GENES ENCODING EXTRACELLULAR/CELL SURFACE PROTEINS, OVARIAN CANCER VERSUS NORMAL ADULT TISSUES

Pkey Pπmekey

Ex Accn Exemplar Accession

UG ID UniGene lD

Title UniGene title

PFAM domains predicted structural domains ratio ratio tumor vs normal

Pkey Ex Accn UG ID Title PFAM domains ratio

400292 AA250737 Hs 72472 BMPR-lb, bone morphogenetic pro pkmase.Activin.recp 300

400289 X07820 Hs 2258 Matnx Metalloprotemase 10 (Strom SS, ,Peptιdase_M10 252

426427 M86699 Hs 169840 TTK protein kinase pkmase 187

4 42244990055 N NMM..000022449977 H Hss 115533770044 NIMA (never in mitosis gene a)-rela pktnase 162

433159 AB035898 Hs 150587 kinesin-like protein 2 k esin 11 5

453370 AI470523 Hs 182356 ESTs, Moderately similar to franslat ABC.tran 84

418007 M13509 Hs 83169 Matnx metalloprotease 1 (mterstitia SS, ,Peptιdase_M10 72

425465 L18964 Hs 1904 protein kinase C, iota Ski Sno.pkmase.C 61

4 40099550066 N NMM..000066115533 H Hss 5544558899 NCK adaptor protein 1 SH2.SH3 52

415539 AI733881 Hs 72472 BMPR-lb, bone morphogenetic pro pkmase.Activin.recp 51

424539 L02911 Hs 150402 activin A receptor, type I Activin recp.pkmase 48

400296 AA305627 Hs 139336 ATP-binding cassette, sub-family C TM.ABC fran 46

431699 NM.001173 Hs 267831 Homo sapiens cDNA FU12952 fis, RhoGAP.FF.ras 39

4 43399556600 B BEE556655664477 H Hss 7744889999 hypothetical protein FLJ 12820 C2,PI-PLC-Y,PI PLC-X 38

450447 AF212223 Hs 25010 hypothetical protein P15-2 ANF.receptor .pkinase 36

400666 X07820 Hs 2258 Matrix Metalloproteinase 10 (Strom SS, jPeptιdase_M10 35

452822 X85689 Hs 288617 Homo sapiens cDNA FU22621 fis, EGF,fn3,pkιnase 34

416530 U62801 Hs 79361 kallikrein 6 (neurosm, zyme) SS M.trypsin 33

4 41111339933 A AWW779977443377 H Hss 6699777711 B-factor, praperdm SS,sushι,frypsm,vwa,frι3 32

444755 AA431791 Hs 183001 ESTs AAA 32

418836 AI655499 Hs 161712 ESTs pkmase.Activin.recp 32

409178 BE393948 Hs 50915 kallikrein 5 SS.trypsin 3 1

406687 M31126 Hs 272620 pregnancy specific beta-1-glycoprat SS,Peptιdase_M10, ,ιg 3 1

4 45533992200 A AII113333114488 H Hss 3366660022 I factor (complement) ldl_recepLa,trypsιn,SRCR 30

404653 AA923729 Hs 26322 0 pkinase 29

419452 U33635 Hs 90572 PTK7 protein tyrosine kinase 7 TM.pkinase.ig 29

418848 AI820961 Hs 193465 ESTs pkιnase,Actιvιn_recp 29

428450 NM.014791 Hs 184339 KIAA0175 gene product TM,ptanase,KA1 28 401323 AL158037 predicted exon lactamase.B 27

444798 BE242144 Hs 12013 ATP-binding cassette, sub-family E SH3,pkιnase .ABC.tran 27

432201 AI538613 Hs 135657 TMPRSS3a mRNA for seπne protea frefoil.frypsin 26

448402 BE244226 Hs 21094 RAB18, member RAS oncogene fam ras.arf 26

406671 AA129547 Hs 285754 met proto-oncogene (hepatocyte gro pkinase.Sema 25

453448 AL036710 Hs 209527 ESTs CNH.pkmase 25

414386 X00442 Hs 75990 haptoglobm sushi.trypsin 25

421270 H56037 Hs 108146 ESTs RhoGAP 24

414695 BE439915 Hs 76913 proteasome (prosome, mxropa ) su proteasome 24

431341 AA307211 Hs 251531 proteasome (prosome, macropain) su proteasome 24

424085 NM.002914 Hs 139226 replication factor C (activator 1) 2(4 AAA,Vιral_helιcase1 22

424687 J05070 Hs 151738 matπx metalloproteinase 9 (gelal a SS,fn2, .Peptidase M10 22

416517 AA775987 Hs 79357 proteasome (prosome, macropain) 26 AAA 22

417601 NM 014735 Hs 82292 KIAA0215 gene product PHD 21

400509 M97639 Hs 155585 receptor tyrosine kmase-like oφhan pro.isomerase 2 1

430057 AW450303 Hs 2534 bone morphogenetic protein recepto Actιvιn_recp,pkιnase 2 1

421841 AA908197 Hs 108850 KIAA0936 protein TPR.pkmase 2 1

453078 AF053551 Hs 31584 metaxin 2 pro.isomerase 2 1

424099 AF071202 Hs 139336 ATP-binding cassette, sub-family C TM,ABC_tran 2 1

411190 AA306342 Hs 69171 protein kinase C-like 2 pkιnase,pkιnase_C,HR1 2 1

407740 AA295547 Hs 62666 ESTs p450 2 1

420162 BE378432 Hs 95577 cyclm-depeπdeπt kinase 4 pkιnase,aπk,ArfGap ,ras 2 1

420490 H69894 Hs 193041 ESTs PI3Ka,PI3_PI4_kιnase 2 1

426156 BE244537 Hs 167382 natπuretic peptide receptor A/guany TM.ANF.receptor .pkinase 20

423945 AA410943 Hs 72472 BMPR-lb, bone morphogenetic pro TM,pkιnase,Actιvιn_recp 20

411773 NM 006799 Hs 72026 protease, seπne, 21 (testism) SS.trypsin 20

447298 BE617527 Hs 180450 πbosomal protein S24 PI3Ka, PI4_kιnase 20

427617 D42063 Hs 179825 RAN binding protein 2-lιke 1 TPR.pro somerase 20

453546 AF042385 Hs 33251 peptidylprolyl isomerase E (cycloph pro.isomerase.rrm 20

TABLE 12C

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham I et al " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489495 Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons

Pkey Ref Strand NLposition 401323 9212516 Plus 213509-214450

Table 13A lists about 1086 genes up regulated in ovanan cancer compared to normal ovanes These were selected as for Table 10A, except that the ratio was greater than or equal to 10, and the denominator was the median value for vaπous non malignant ovary specimens TABLE 13A About 1086 UP-REGULATED GENES, OVARIAN CANCER VERSUS NORMAL OVARY

Pkey Pπmekey

Ex Accn Exemplay Accession

UG ID UπiGene lD

Title UniGene title ratio ration tumor vs normal ovary

Pkey Ex Accn UG ID Title ratio

439706 AW872527 Hs 59761 ESTs 1092

446619 AU076643 Hs 313 secreted phosphoprotein 1 (osteopontiπ, bone 1078

422095 AI868872 Hs 288966 ceruloplasmin (ferroxidase) 1044

447111 AI017574 Hs 17409 cysteine-πch protein 1 (intestinal) 883

431130 NM 006103 Hs 2719 epididymis-specific, whey-acidic protein type 828

431369 BE184455 Hs 251754 secretory leukocyte protease inhibitor (antil 81 9

413859 AW992356 Hs 8364 ESTs 739

446291 BE397753 Hs 14623 interferon, gamma-inducible protein 30 727

426050 AF017307 Hs 166096 E74-lιke factor 3 (ets domain franscπptioπ f 681

411469 T09997 Hs 70327 cysteine πch protein 2 666

429504 X99133 Hs 204238 lipocalin 2 (oncogene 24p3) 657

416971 R34657 Hs 80658 uncoupling protein 2 (mitochondπal, proton c 649

450273 AW296454 Hs 24743 hypothetical protein FU20171 625

446441 AK001782 Hs 15093 hypothetical protein 607

428758 AA433988 Hs 98502 Homo sapiens cDNA FU14303 fis, clone PLACE20 597

441406 Z45957 Hs 7837 Homo sapiens cDNA FU10457 fis, clone NT2RP10 578

441859 AW194364 Hs 128022 ESTs, Weakly similar to FIG1 MOUSE FIG-1 PROT 567

448406 AW772298 Hs 21103 Homo sapiens mRNA, cDNA DKFZp564B076 557

414602 AW630088 Hs 76550 Homo sapiens mRNA, cDNA DKFZp564B1264 552

418068 AW971155 Hs 293902 ESTs, Weakly similar to prolyl 4-hydroxylase 548

428330 L22524 Hs2256 matπx metalloproteinase 7 (malnlysin, uten 534

412636 NM 004415 Hs 74316 desmoplakin (DPI, DPII) 51 4

430634 AI860651 Hs 26685 ESTs 507

439318 AW837046 Hs 6527 G protein-coupled receptor 56 507

417259 AW903838 Hs 81800 chondroitin sulfate proteoglycan 2 (versican) 506

407786 AA687538 Hs 38972 tetraspan 1 504

426836 N41720 Hs 172684 vesicle-associated membrane protein 8 (endobr 497

417308 H60720 Hs 81892 KIAA0101 gene product 489

436876 AI124756 Hs 5337 isocitrate dehydrogenase 2 (NADP+), mitochond 484

439180 AI393742 Hs 199067 v-erb-b2 avian erythroblastic leukemia viral 471

428289 M26301 Hs 2253 complement component 2 463

405484 0 461 425371 D49441 Hs 155981 mesothelm 457

403912 0 450

443021 AA368546 Hs 8904 Ig superfamily protein 446

427697 T18997 Hs 180372 BCL2-lιke 1 443

428227 AA321649 Hs 2248 INTERFERON GAMMA INDUCED PROTEIN 440

404678 0 439

400289 X07820 Hs 2258 Matπx Metalloproteinase 10 (Stromolysin 2) 43 8

451035 AU076785 Hs 430 plastm 1 (I isoform) 438

440848 BE314650 Hs 7476 ATPase, H+ transporting, lysosomal (vacuolar 428

436278 BE396290 Hs 5097 synaptogyπn 2 424

413936 AF113676 Hs 75621 seπne (or cysteine) protemase inhibitor, cl 421

420859 AW468397 Hs 100000 SlOOcalcium binding protein A8 (calgranulm 421

428411 AW291464 Hs 10338 ESTs 41 8

422166 W72424 Hs 112405 S100 catcium-biπding protein A9 (calgranulm 41 5

412477 AA150864 Hs 790 microsomal glutathione S-transferase 1 407

417130 AW276858 Hs 81256 S100 calcium-binding protein A4 (calcium prot 401

424673 AA345051 Hs 294092 ESTs 398

416530 U62801 Hs 79361 kallikrein 6 (neurosm, zyme) 397

443162 T49951 Hs 9029 ESTs, Highly similarto KERATIN, TYPE 1 CYTO 395

413719 BE439580 Hs 75498 small inducible cytokine subfamily A (Cys-Cys 393

424687 J05070 Hs 151738 matπx metalloproteinase 9 (gelatmase B, 92k 389

413063 AL035737 Hs 75184 chitmase 3-lιke 1 (cartilage glycoproteιn-39 385

429441 AJ224172 Hs 204096 lipophilin B (uteroglob family member), pro 38 1

418526 BE019020 Hs 85838 solute earner family 16 (monocarboxylio acid 379

415511 AI732617 Hs 182362 ESTs 377

409453 AI885516 Hs 95612 ESTs 377

445537 AJ245671 Hs 12844 EGF-like-domain, multiple 6 373

442432 BE093589 Hs 38178 Homo sapiens cDNA FLJ23468 fis, clone HSU 16 373

408243 Y00787 Hs 624 interieukin 8 373

419092 J05581 Hs 89603 mucm 1, transmembrane 367

444172 BE147740 Hs 104558 ESTs 360

412115 AK001763 Hs 73239 hypothetical protein FLJ10901 358

420440 NM 002407 Hs 97644 mammaglobm 2 357

414386 X00442 Hs 75990 haptoglobm 353

423225 AA852604 Hs 125359 Thy-1 cell surface antigen 35 1

440596 H13032 Hs 103378 ESTs, Weakly similarto DRR1 [H sapiens] 350

413278 BE563085 Hs 833 iπterferon-stimulated protein, 15 kDa 349

418506 AA084248 Hs 85339 G protein-coupled receptor 39 348

445919 T53519 Hs 290357 ESTs 347

416854 H40164 Hs 80296 Purkinje cell protein 4 344

414186 U33446 Hs 75799 protease, seπne, 8 (prostasiπ) 342

434371 AA631362 gb np86b01 s1 NCI.CGAP.Thyl Homo sapiens cDNA 339

421937 AI878857 Hs 109706 HN1 protein 339

449722 BE280074 Hs 23960 cyclin B1 338

400965 0 337

452203 X57522 Hs 158164 ATP-bmdmg cassette, sub-family B (MDR TAP), 335

411945 AL033527 Hs 92137 v-myc avian myelocytomatosis viral oncogene h 335

425811 AL039104 Hs 159557 karyopheππ alpha 2 (RAG cohort 1, import a 334

408901 AK001330 Hs 48855 hypothetical protein FU 10468 333

438461 AW075485 Hs 286049 phosphoseπne aminotraπsferase 333

422963 M79141 Hs 13234 ESTs 333

426158 NM 001982 Hs 199067 v-erb-b2 avian erythroblastic leukemia viral 332

431836 AF178532 Hs 271411 beta-site APP-cleavmg enzyme 2 328

421502 AF111856 Hs 105039 solute earner family 34 (sodium phosphate), 325

431211 M86849 Hs 5566 Homo sapiens connexin 26 (GJB2) mRNA, complet 325

436552 NM 014038 Hs 5216 HSPC028 protein 325

442533 AA161224 Hs 8372 ubiquinol-cytochrome c reductase (64kD) subu 325

406400 AA343629 Hs 104570 kallikrein 8 (neuropsm/ovasin) 324

450353 A1244661 Hs 103296 ESTs 324

422158 L10343 Hs 112341 protease inhibitor 3, skm-deπved (SKALP) 324

433412 AV653729 Hs 8185 CGI44 protein, sulfide dehydrogenase like (y 323

441020 W79283 Hs 35962 ESTs 322

432201 AI538613 Hs 135657 TMPRSS3a mRNA for seππe protease (ECHOS1) (T 320

424125 M31669 Hs 1735 inhibiπ, beta B (activin AB beta polypeptide) 31 9

453309 AI791809 Hs 32949 defensin, beta 1 31 8

408380 AF123050 Hs 44532 diubiquitm 31 7

419329 AY007220 Hs 288998 S100-type calcium binding protein A14 31 6

409231 AA446644 Hs 692 GA733-2, epithelial glycoprotein (EGP) (KSA) 31 6

423961 D13666 Hs 136348 Homo sapiens mRNA for osteoblast specific fac 31 2

413840 AI301558 Hs 290801 ESTs 308

440943 AW082298 Hs 146161 ESTs, Weakly similar to KIAA0859 protein [H s 308

419239 AA468183 Hs 184598 Homo sapiens cDNA FU23241 fis, clone COL013 304

410132 NM 003480 Hs 58882 Microfibπl associated glycoprotein-2 302

418203 X54942 Hs 83758 CDC28 protein kinase 2 301

412719 AW016610 Hs 129911 ESTs 300

407862 BE548267 Hs 50724 Homo sapiens cDNA FU10934 fis, clone OVARC10 300

431563 AI027643 Hs 120912 ESTs 299

431743 AW972642 Hs 293055 ESTs 298

443295 AI049783 Hs 241284 ESTs 297

413745 AW247252 Hs 75514 nucleoside phosphorylase 297

441028 AI333660 Hs 17558 ESTs 296

442315 AA173992 Hs 7956 ESTs 296

452838 U65011 Hs 30743 Preferentially expressed antigen in melanoma 295

428479 Y00272 Hs 184572 cell division cycle 2, G1 to S and G2 to M 295 432280 BE440142 Hs 2943 signal recognition particle 19kD 294

420158 AI791905 Hs 95549 hypothetical protein 293

445033 AV652402 Hs 155145 ESTs 29 2

452367 U71207 Hs 29279 eyes absent (Drosophila) homolog 2 29 1

432706 NM 013230 Hs 286124 CD24 290

422163 AF027208 Hs 297332 praminin (mouse)-lιke 1 287

447035 NM 004753 Hs 17144 short-chain dehydrogenase/reductase 1 286

443958 BE241880 Hs 10029 cathepsin C 282

422956 BE545072 Hs 122579 ESTs 28 1

450377 AB033091 Hs 24936 ESTs 280

447471 AF039843 Hs 18676 sprouty (Drosophila) homolog 2 280

444725 AW952022 Hs 234174 Homo sapiens cDNA FU13819 fis, clone THYRO10 278

430250 NM 016929 Hs 283021 chloπde intracellular channel 5 277

416305 AU076628 Hs 79187 coxsackie virus and adenovirus receptor 276

418174 L20688 Hs 83656 Rho GDP dissociation inhibitor (GDI) beta 27 5

417233 W25005 Hs 24395 small inducible cytokine subfamily B (Cys-X-C 274

417866 AW067903 Hs 82772 collagen, type XI, alpha 1 273

427344 NM 000869 Hs 2142 5-hydroxyfryptamιne (serotonin) receptor 3A 272

442993 BE018682 Hs 44343 ESTs 272

407137 T97307 Hs 199067 v-erb-b2 avian erythroblastic leukemia viral 270

419356 AI656166 Hs 7331 ESTs 270

433662 W07162 Hs 150826 CATX-8 protein 267

422576 BE548555 Hs 118554 CGI-83 protein 264

423271 W47225 Hs 126256 interieukin 1, beta 26 3

443715 AI583187 Hs 9700 cyclin E1 261

420186 NM 015925 Hs 95697 liver-specific'bHLH-Zip transcπptioπ factor 260

419551 AW582256 Hs 91011 anteπor gradient 2 (Xenepus laevis) homolog 259

443672 AA323362 Hs 9667 butyrobetaine (gamma), 2-oxoglutarate dioxyge 258

416889 AW250318 Hs 80395 mal, T-cell differentiation protein 253

408474 AA188823 Hs 83196 Homo sapiens cDNA FU23597 fis, clone LNG152 253

411825 AK000334 Hs 72289 hypothetical protein FU20327 253

400881 0 252

440594 AW445167 Hs 126036 ESTs 25 1

414586 AA306160 Hs 76506 lymphocyte cytosolic protein 1 (L-plastm) 251

411925 AW014588 Hs 72925 chromosome 11 open reading frame 13 251

417869 BE076254 Hs 82793 proteasome (prosome, macropain) subunit, beta 250

433447 U29195 Hs 3281 neuronal penlraxin II 250

450858 C18458 Hs 25597 elongation of very long chain fatty acids (FE 248

410619 BE512730 Hs 65114 keratin 18 248

434094 AA305599 Hs 238205 hypothetical protein PRO2013 246

421924 BE514514 Hs 109606 coronin, actin-bmding protein, 1A 246

446859 A1494299 Hs 16297 COX17 (yeast) homolog, cytochrome c oxidase a 24 5

421451 AA291377 Hs 50831 ESTs 243

433929 AI375499 Hs 27379 ESTs 243

438930 AW843633 Hs 81256 S100 calcium binding protein A4 (calcium prot 242

444212 AW503976 Hs 10649 basement membrane-mduced gene 242

441633 AW958544 Hs 112242 ESTs 242

441134 W29092 Hs 7678 cellular retmoic xid-bmding protein 1 242

417715 AW969587 Hs 86366 ESTs 241

409361 NM.005982 Hs 54416 sine oculis homeobox (Drosophila) homolog 1 241

416984 H38765 Hs 80706 diaphorase (NADH/NADPH) (cytochrome b-5 reduc 241

430125 U46418 Hs 233950 seπne protease inhibitor, Kunifz type 1 23 9

434078 AW880709 Hs 283683 * EST 238

408669 AI493591 Hs 78146 platelet/eπdothelial cell adhesion molecule ( 238

439413 AI598252 Hs 37810 ESTs 237

449034 AI624049 Hs 277523 gb ts41a09 x1 NCI.CGAP.Ut1 Homo sapiens cDNA 237

420344 BE463721 Hs 97101 Putative G protein-coupled receptor GPCR150 23 6

431243 U46455 Hs 252189 syndecan 4 (amphiglycan, ryudocan) 236

417515 L24203 Hs 82237 ataxia-telangiectasia group D-associated prot 235

451267 AI033894 Hs 117865 solute earner family 17 (amon/sugar transpo 234

450101 AV649989 Hs 24385 Human hbc647 mRNA sequence 234

419693 AA133749 Hs 92323 FXYD domain-containing ion transport regulato 234

431103 M57399 Hs 44 pleiotrophin (hepaπn binding growth factor 8 234

451110 AI955040 Hs 301584 ESTs 233

426295 AW367283 Hs 75839 zinc finger protein 6 (CMPX1) 232

448517 AA082750 Hs 42194 hypothetical protein FU22649 similarto sign 231

424670 W61215 Hs 116651 epithelial V-like antigen 1 231

417847 AI521558 Hs 288312 Homo sapiens cDNA FU22316 fis, clone HRC052 23 1

449027 AJ271216 Hs 22880 dipeptidylpeptidase III 231

424969 AW950928 Hs 153998 creatine kinase, mitochondπal 1 (ubiquitous) 231

433159 AB035898 Hs 150587 kmesiπ like protein 2 230

411393 AW797437 Hs 69771 B-factor, properdin 230

434815 AF155582 Hs 46744 Corel UDP-galactose N-acetylgalactosamine-alp 228

427585 D31152 Hs 179729 collagen, type X, alpha 1 (Schmid metaphyseal 227

445721 H92136 Hs 13144 HSPC160 protein 226

448258 BE386983 Hs 85015 ESTs, Weakly similar to A4P.HUMAN INTESTINAL 226

456844 AI264155 Hs 152981 CDP-diacylglycerol synthase (phosphatidate cy 226

452698 NM 001295 Hs 301921 ESTs 225

418693 AI750878 Hs 87409 thrombospondin 1 224

414880 AW247305 Hs 119140 eukaryotic translation initiation factor 5A 224

401519 0 223

402496 0 223

420324 AF163474 Hs 96744 DKFZP586D0823 protein, Prostate aπdrogen-regu 223

403022 0 222 434042 AI589941 Hs 8254 hypothetical protein PRO0899 221

419080 AW150835 Hs 18878 hypothetical protein FU21620 221

406545 AB018249 Hs 10458 small inducible cytokine subfamily A (Cys Cys 221

447362 AW176120 Hs 9061 ESTs 220

429547 AW009166 Hs 99376 ESTs 220

427954 J03060 Hs 247551 metaxin 1 220

423161 AL049227 Hs 124776 Homo sapiens mRNA, cDNA DKFZp564N1116 (from c 220

428392 H10233 Hs 2265 secretory granule, neuroendocπne protein 1 ( 21 9

444107 T46839 Hs 10319 UDP glycosyltraπsferase 2 family, polypeptide 21 7

414421. AI521130 Hs 55567 ESTs, Weakly similar to LAK4p H sapiens] 21 5

412589 R28660 Hs 24305 ESTs 21 5

446525 AW967069 Hs 211556 Homo sapiens cDNA FU23378 fis, clone HEP162 21 5

416847 L43821 Hs 80261 enhancer of filamentatioπ 1 (cas like docking 21 5

436972 AA284679 Hs 25640 daudin 3 21 5

428698 AA852773 Hs 297939 ESTs, Weakly similar to neogenm [H sapiens] 21 5

421340 F07783 Hs 1369 decay accelerating factor for complement (CD5 21 4

413966 AA133935 Hs 173704 ESTs 21 4

448243 AW369771 Hs 77496 ESTs 21 3

421928 AF013758 Hs 109643 polyadenylate binding protein interacting pro 21 3

403399 0 21 3

435793 AB037734 Hs 4993 ESTs 21 3

432629 AW860548 Hs 280658 ESTs 21 2

449057 AB037784 Hs 22941 ESTs 21 2

437575 AW954355 Hs 36529 ESTs 21 2

401131 0 21 0

407207 T03651 Hs 179661 tubulin, beta'polypeptide 208

444783 AK001468 Hs 62180 ESTs 208

426230 AA367019 Hs 241395 protease, seπne, 1 (frypsm 1) 20 8

447343 AA256641 Hs 236894 ESTs, Highly similarto LOW-DENSITY UPOPROTE 207

409041 AB033025 Hs 50081 KIAA1199 protein 206

421305 BE397354 Hs 289721 diptheπa toxin resistance protein required f 206

411704 AI499220 Hs 71573 hypothetical protein FU 10074 205

417018 M16038 Hs 80887 v-yes 1 Yamaguchi sarcoma viral related oncog 205

432827 Z68128 Hs 3109 Rho GTPase activating protein 4 204

410174 AA306007 Hs 59461 DKFZP434C245 protein 204

425184 BE278288 Hs 155048 Lutheran blood group (Auberger b antigen mcl 204

452322 BE566343 Hs 28988 glutaredoxin (thioltransferase) 203

447526 AL048753 Hs 340 small inducible cytokine A2 (monocyte chemota 202

447335 BE617695 Hs 286192 protein phosphatase 1, regulatory (inhibitor) 202

424867 AI024860 Hs 153591 Not56 (D melanogaster) like protein 20 1

410275 U85658 Hs 61796 traπscπption factor AP-2 gamma (activating e 201

429083 Y09397 Hs 227817 BCL2 related protein A1 200

410173 AA706017 Hs 119944 ESTs 198

433047 M86135 Hs 279946 methionine tRNA synthetase 198

419088 AI538323 Hs 77496 ESTs 197

403381 0 196

409162 H25530 Hs 50868 solute earner family 22 (organic cation Iran 195

426150 NM 003658 Hs 167218 BarH like homeobox 2 194

449292 AI990292 Hs 225457 ESTs 194

425207 AB014551 Hs 155120 rho/rac guanine nucleotide exchange factor (G 194

419950 AK001645 Hs 93871 hypothetical protein FU 10783 193

436481 AA379597 Hs 5199 HSPC150 protein similarto ubiquitm-conjugat 193

445930 AF055009 Hs 13456 Homo sapiens clone 24747 mRNA sequence 192

446608 N75217 Hs 257846 ESTs 191

425222 M85430 Hs 155191 villm 2 (ezππ) 191

428309 M97815 Hs 183650 cellular retmoic acid binding protein 2 191

420005 AW271106 Hs 133294 ESTs 19 1

436982 AB018305 Hs 5378 spondin 1, (f-spondin) extracellular matπx p 190

407142 AA412535 Hs 55235 sphmgomyelin phosphodiesterase 2, neutral me 190

430122 NM 013342 Hs 233765 TCF3 (E2A) fusion partner (in childhood Leuke 189

446293 AI420213 Hs 149722 ESTs 189

444825 AW167613 Hs 248 mitogen-activated protein kinase kinase kinas 189

407634 AW016569 Hs 301280 UDP-GlcNAc betaGal beta-1,3-N-acetylglucosamι 189

445200 AA084460 Hs 12409 somatostat 18 9

418917 X02994 Hs 1217 adenosme deammase 18 8

435777 AW419202 Hs 286192 protein phosphatase 1, regulatory (inhibitor) 188

431049 AA846576 Hs 103267 hypothetical protein FU22548 similar to gene 187

426427 M86699 Hs 169840 TTK protein kinase 187

436281 AW411194 Hs 120051 ESTs 186

425907 AA365752 Hs 155965 ESTs 186

459720 ESTs 186

421242 AW161386 Hs 13561 ESTs, Weakly similarto dJ37E165 [H sapiens] 18 5

457715 AA642402 Hs 59142 ESTs 18 5

451668 Z43948 Hs 26789 ASPIC (acidic secreted protein in cartilageJA 184

437142 AI791617 Hs 145068 ESTs 184

418588 BE387040 Hs 182476 ESTs, Weakly similar to similar to alpha/beta 183

433068 NM 006456 Hs 288215 sialylfransferase 183

419854 AW664873 Hs 87836 Homo sapiens PAC clone RP5-1087M19 from 7q11 183

444726 NM 006147 Hs 11801 interferon regulatory factor 6 183

423011 NM 000683 Hs 299847 ESTs, Highly similar to A2AD.HUMAN ALPHA 2C-2 182

451428 AW083334 Hs 11067 ESTs, Weakly similar to K02E102 [C elegans] 182

424865 AF011333 Hs 153563 lymphocyte antigen 75 182

418742 AW451197 Hs 113418 ESTs 181

446627 AI973016 Hs 15725 ESTs, hypothetical protein SBBI48 18 1 424885 AI333771 Hs 82204 ESTs 181

402926 0 180

405452 0 180

428641 AA431367 Hs 234546 GMPR2 for guanosme monophosphate reductase i 180

454390 AB020713 Hs 56966 KIAA0906 protein 180

441784 AI522132 Hs 28700 ESTs 180

418758 AW959311 Hs 87019 ESTs 179

408621 AI970672 Hs 46638 chromosome 11 open reading frame 8, fetal br 179

426201 AW182614 Hs 128499 ESTs 178

410442 X73424 Hs 63788 propionyl Coenzyme A carboxylase, beta polype 178

456423 AW748920 gb CM2-BT0306-171199 034-g02 BT0306 Homo sapi 178

422867 L32137 Hs 1584 cartilage oligomeπc matπx protein 178

448110 AA626937 Hs 181551 ESTs 177

421750 AK000768 Hs 107872 hypothetical protein FLJ20761 17 7

405224 0 177

447630 AI660149 Hs 44865 lymphoid enhancer-binding factor 1 177

407663 NM 016429 Hs 37482 COPZ2 for nondathnn coat protein zeta-COP 177

427490 Z95152 Hs 178695 mitogen-activated protein kinase 13 176

414812 X72755 Hs 77367 monokine induced by gamma interferon 176

427691 AW194426 Hs 20726 ESTs 176

420650 AA455706 Hs 44581 heat shock protein hsp70-related protein 17 5

439841 AF038961 Hs 6710 maπnose-P-dolichol utilization defect 1 17 5

425810 AI923627 Hs 31903 ESTs 175

425397 J04088 Hs 156346 topoisomerase (DNA) II alpha (170kD) 175

456098 AW747800 Hs 55016 hypotheticajprotein FU21935 174

428579 NM.005756 Hs 184942 G protein-coupled receptor 64 17 4

410361 BE391804 Hs 62661 guanylate binding protein 1, interferon-induc 174

442402 NM 000954 Hs 8272 prostaglandin D2 synthase (21 kD, brain) 174

411734 AW374954 Hs 71779 Homo sapiens DNA from chromosome 19, cosmid F 17 3

405295 0 173

408340 AB037762 Hs 44268 myelm gene expression factor 2 173

456068 AI677897 Hs 76640 RGC32 protein 173

448571 AA486794 Hs 66915 ^" ESTs, Weakly similarto 167Kd protein [H sap 17 2

441829 AU 17482 Hs 7978 DKFZP434C131 protein 17 2

418004 U37519 Hs 87539 aldehyde dehydrogenase 8 172

412078 X69699 Hs 73149 paired box gene 8 172

414658 X58528 Hs 76781 ATP-bmdmg cassette, sub-family D (ALD), mem 17 1

418478 U38945 Hs 1174 cyclm-dependent kinase inhibitor 2A (melanom 170

426805 AB032945 Hs 172506 myosin VB 170

410247 AF181721 Hs 61345 RU2S 170

434516 AA807814 Hs 70582 ESTs, Moderately similar to AF1440561 apopto 169

428153 AW513143 Hs 98367 hypothetical protein FLJ22252 similar to SRY- 169

417793 AW405434 Hs 82575 small nuclear nbonucleoprotein polypeptide B 169

454163 AW175997 gb QV0-BT0078-190899005-E02 BT0078 Homo sapi 169

415402 AA164687 Hs 297889 ESTs 169

420309 AW043637 Hs 21766 ESTs 169

419201 M22324 Hs 1239 alanyl (membrane) aminopeptidase (aminopeptid 169

444391 AL137597 Hs 11114 hypothetical protein dJ1181N3 1 169

457705 AW974668 gb EST386757 MAGE resequences, MAGM Homo sapi 168

412723 AA648459 Hs 179912 ESTs 16 8

435774 R88066 Hs 992 tumor suppressing subtransferable candidate 1 168

408753 AI337192 Hs 47438 SH3 domain binding glutamic acid πch protein 168

447783 AF054178 Hs 19561 NADH dehydrogenase (ubiqumone) 1 alpha subco 16 8

418085 R40328 Hs 258822 ESTs 167

452472 AW957300 Hs 294142 ESTs, Weakly similar to SP49.HUMAN SPUCEOSOM 167

409112 BE243971 Hs 50649 qumone oxidoreductase homolog 167

410250 AI082777 Hs 61384 KIAA1445 protein 167

446219 AI287344 Hs 149827 ESTs 166

428928 BE409838 Hs 194657 cadheπn 1, type 1, E-cadheπn (epithelial) 166

425812 AA364128 Hs 245633 ESTs 166

411742 AW247593 Hs 71819 eukaryotic translation initiation factor 4E b 166

415076 NM 000857 Hs 77890 guanylate cyclase 1, soluble, beta 3 16 6

416209 AA236776 Hs 79078 MAD2 (mitotic arrest deficient, yeast, homolo 16 6

440667 BE076969 Hs 7337 hypothetical protein FU 10936 16 6

430375 AW371048 Hs 93758 H4 histone family, member H 16 6

419607 R52557 Hs 91579 Homo sapiens clone 23783 mRNA sequence 166

410328 BE080190 Hs 62275 CGI-141 protein 16 5

405426 0 16 5

432636 AA340864 Hs 278562 audin 7 16 5

434725 AK000796 Hs 4104 hypothetical protein 165

414683 S78296 Hs 76888 internexin neuronal intermediate filament pro 16 5

429500 X78565 Hs 289114 hexabrachion (tenasciπ C, cytotact ) 165

449944 AF290512 Hs 58215 Homo sapiens rhotekm mRNA, partial eds 164

400666 0 164

421536 BE250690 Hs 105509 CTL2 geπe 164

436032 AA150797 Hs 109276 latexin protein 164

418196 AI745649 Hs 26549 ESTs, Weakly similar to T00066 hypothetical p 164

452323 W44356 Hs 292812 ESTs, Weakly similarto C43H8 1 [C elegans] 164

407699 AA825974 Hs 32646 Homo sapiens cDNA FU21901 fis, clone HEP034 164

414617 AI339520 Hs 20524 ESTs, Moderately similarto hexokmase 1 [H s 163

408204 AA454501 Hs 43666 protein tyrosine phosphatase type IVA, member 163

452650 AW270150 Hs 254516 ESTs 16 3

432906 BE265489 Hs 3123 lethal giant larvae (Drosophila) homolog 2 163

402408 0 163 408805 H69912 Hs.48269 vaccinia related kinase 1 16.3

447155 AA100605 Hs.121557 ESTs, Weakly similar to AF251041 1 SGC32445 p 16.3

405699 0 16.2

406893 M22406 gb:Human intestinal mucin mRNA, partial eds, 16.2

418629 BE247550 Hs.86859 growth factor receptor-bound protein 7 (GRB7) 16.2

424905 NM.002497 Hs.153704 NIMA (never in mitosis gene a)-related kinase 16.2

424243 AI949359 Hs.301837 ESTs, Highly similar to cis Golgi-localized c 16.2

418462 BE001596 Hs.85266 integrin, beta 4 16.1

457205 AI905780 Hs.198272 NADH dehydrogenase (ubiquinoπe) 1 beta subcom 16.1

428188 M98447 Hs.22 transglutammase 1 (K polypeptide epidermal t 16.1

449845 AW971183 Hs.60054 ESTs 16.1

406429 0 16.1

407375 AA091354 gb:ll0815.seq.F Human fetal heart, Lambda ZAP 16.1

448377 AI494514 Hs.171380 ESTs 16.1

431156 NM 002220 Hs.2722 iπositol 1 ,4,5-trisphosphate 3-kinase A 16.0

450043 AA885699 Hs.24332 CGI-26 protein 16.0

403121 0 16.0

400214 0 15.9

453252 R02436 Hs.215725 ESTs 15.9

451734 NM.006176 Hs.26944 neurogranin (protein kinase C substrate, RC3) 15.9

416855 AA188763 Hs.36793 Homo sapiens cDNA: FU23188 fis, clone LNG120 15.9

424474 AA308883 Hs.148680 calcyon; D1 dopamine receptor-interacting pro 15.9

423685 BE350494 Hs.49753 Homo sapiens mRNA for KIAA1561 protein, parti 15.9

428187 AI687303 Hs.285529 ESTs 15.9

438817 AI023799 Hs.163242 ESTs 15.9

425692 D90041 Hs.155956 NAT1; arylamine N-acetyltraπsferase 15.9

421674 T10707 Hs.296355 neuronal PAS domain protein 2 15.9

439999 AA115811 Hs.6838 ras homolog gene family, member E 15.9

411351 W02919 Hs.283476 peroxisomal xyl-CoA thioesterase 15.9

413027 NM.002885 Hs.75151 RAP1, GTPase activating protein 1 15.9

453884 AA355925 Hs.36232 KIAA0186 gene product 15.8

407894 AJ278313 Hs.41143 phosphoinositide-specific phospholipase C-bet 15.8

422748 AA316266 Hs.129349 ESTs 15.8

414591 AI888490 Hs.55902 ESTs 15.8

421877 AW250380 Hs.109059 mitochondrial ribosomal protein L12 15.8

404780 0 15.8

401192 0 15.8

447519 U46258 Hs.23448 ESTs 15.8

434262 AF121858 Hs.12169 sorting nexin 8 15.7

451253 H48299 Hs.26126 daudin 10 15.7

435499 R89344 Hs.14148 ESTs 15.7

422424 AI186431 Hs.116577 prostate differentiation factor; placental bo 15.7

424834 AK001432 Hs.153408 Homo sapiens cDNA FLJ10570 fis, clone NT2RP20 15.7

424562 AI420859 Hs.150557 basic transcription element binding protein 1 15.7

443247 BE614387 Hs.47378 ESTs 15.7

430696 AA531276 Hs.59509 ESTs 15.6

437044 AL035864 Hs.69517 ESTs, highly similar to differentially expres 15.6

428237 AF175206 Hs.183125 killer cell lectin-like receptor F1 15.6

440048 AA897461 Hs.158469 ESTs, Weakly similar to envelope protein [H.s 15.6

414922 D00723 Hs.77631 glycine cleavage system protein H (aminomethy 15.6

422030 X51416 Hs.110849 estrogen-related receptor alpha 15.6

408716 AI567839 Hs.151714 ESTs 15.5

410258 X52638 Hs.739 6-phosphofructc-2-kinase/fructose-2,6-biphosp 15.5

410530 M25809 Hs.64173 ESTs, Highly similar to VAB1.HUMAN VACUOLAR A 15.5

447072 D61594 Hs.17279 tyrasylprotein sulfofransferase 1 15.5

409015 BE389387 Hs.49767 NADH dehydrogenase (ubiquinone) Fe-S protein 15.5

447549 AI871120 ^• Hs.231265 ESTs 15.5

449704 AK000733 Hs.23900 GTPase activating protein 15.4

427337 Z46223 Hs.176663 Fc fragment of IgG, low affinity lllb, recept 15.4

421630 NM 001956 Hs.1407 endotheliπ 2 15.4

433018 AI669760 Hs.188881 ESTs 15.4

422938 NM.001809 Hs.1594 centromere protein A (17kD) 15.3

407014 U38268 gb:Human cytochrome b pseudogene, partial eds 15.2

429311 AF080157 Hs.198998 conserved helix-loop-helix ubiquitous kinase 15.2

431842 NM 005764 Hs.271473 epithelial protein up-regulated in carcinoma, 15.2

406907 Z25427 gb:H.sapieπs protein-serine/threonine kinase 15.2

458495 AI202029 Hs.148593 ESTs 15.2

420551 AL137692 Hs.98790 Homo sapiens mRNA; cDNA DKFZp434P182 (from cl 15.1

448443 AW167128 Hs.231934 ESTs 15.1

443646 AI085198 Hs.298699 ESTs 15.1

431538 AL137547 Hs.259619 Homo sapiens mRNA; cDNA DKFZp434B1120 (from c 15.1

436687 AA868643 Hs.120461 ESTs 15.1

420917 AW135716 Hs.117330 ESTs 15.0

428575 M19684 Hs.184929 serine (or cysteine) prateinase inhibitor, cl 15.0

403482 0 15.0

421499 AI271438 Hs.105022 Homo sapiens PAC clone RP4-701O16 from 7q33-q 15.0

401047 0 14.9

417749 U09196 Hs.82520 polymerase (DNA-directed), delta 4 14.9

416693 AI373204 Hs.79531 Homo sapiens TTF-I interacting peptide 20 mRN 14.9

428474 AB023182 Hs.184523 KIAA0965 protein 14.9

428862 NM 000346 Hs.2316 SRY (sex-determining region Y)-box 9 (campome 14.9

430271 T06199 Hs.237506 heat shock cognate 40 14.9

414328 Z21666 Hs.75900 aconitase 2, mitochondrial 14.9

415314 N88802 Hs.5422 glycoprotein M6B 14.8 453735 AI066629 Hs 125073 ESTs 148

424345 AK001380 Hs 145479 Homo sapiens cDNA FU10518 fis, clone NT2RP20 148

423575 C18863 Hs 163443 ESTs 148

438081 H49546 Hs 298964 ESTs 148

403485 0 148

452114 N22687 Hs 8236 ESTs 148

426559 AB001914 Hs 170414 paired basic ammo acid cleaving system 4 148

412869 AA290712 Hs 82407 Homo sapiens HSPC296 mRNA, partial eds 148

452101 T60298 gb yb87f12 r1 Stratagene liver (937224) Homo 147

420505 AW967984 Hs 291612 ESTs 147

426125 X87241 Hs 166994 FAT tumor suppressor (Drosophila) homolog 147

433336 AF017986 Hs 31386 ESTs, Highly similarto FRIZZLED PROTEIN PRE 147

428977 AK001404 Hs 194698 cyclin B2 147

429785 H82114 Hs 301769 ESTs 147

402424 0 147

424971 AA479005 Hs 154036 tumor suppressing subtransferable candidate 3 147

433037 NM 014158 Hs 279938 HSPC067 protein 146

421670 BE207318 Hs 106674 BRCA1 associated prateιn-1 (ubiquitin carboxy 146

438598 AI805943 Hs 5723 Homo sapiens cDNA FLJ23439 fis, clone HSI001 146

453370 AI470523 Hs 182356 ESTs, Moderately similar to translation miti 146

410561 BE540255 Hs 6994 Homo sapiens cDNA FU22044 fis, clone HEP091 146

402287 0 146

419741 NM 007019 Hs 93002 ubiquitin earner protein E2-C 146

442047 AA974598 Hs 150324 ESTs 145

428582 BE336699 Hs 185055 BENE protein 145

440006 AK000517 Hs 6844 hypothetical protein FLJ20510 145

406851 AA609784 Hs 180255 major histocompatibility complex, class II, D 145

457316 AI123657 Hs 127264 ESTs 145

420453 AL157500 Hs 97840 Homo sapiens mRNA, cDNA DKFZp434G015 (from cl 145

436406 AW105723 Hs 125346 ESTs 145

420736 AI263022 Hs 82204 ESTs 145

419743 AW408762 Hs 127478 ESTs 145

429113 D28235 Hs 196384 Prostaglandin-endoperaxide synthase 2 (COX-2) 145

450256 AA286887 Hs 24724 MFH-a plified sequences with leucme-πch tan 145

424906 AI566086 Hs 153716 Homo sapiens mRNA for Hmob33 protein, 3' uπtr 145

427414 F11750 Hs 6647 Homo sapiens cDNA FU13088 fis, clone NT2RP30 144

419839 U24577 Hs 93304 phospholipase A2, group VII (platelet activat 144

418738 AW388633 Hs 6682 solute earner family 7, member 11 143

429414 AI783656 Hs 202095 empty spiracles (Drosophila) homolog 2 143

424669 AA417181 Hs 120858 Homo sapiens cDNA FU 13945 fis, clone Y79AA10 143

408989 AW361666 Hs 49500 KIAA0746 protein 143

406788 AI911841 Hs 5184 TH1 drosophila homolog 143

417861 AA334551 Hs 82767 sperm specific antigen 2 143

402104 0 143

416368 R88849 gb ym96a06 r1 Soares adult brain N2b4HB55Y Ho 142

405802 0 142

448357 N20169 Hs 108923 ESTs 142

444261 AA298958 Hs 10724 MDS023 protein 142

407846 AA426202 Hs 40403 Cbp/p300-ιnteractιng transactivator, with Glu 142

425163 D10040 Hs 154890 fatty-acid-Coeπzyme A ligase, long-chain 2 141

402520 0 141

429597 NM 003816 Hs 2442 a disintegπn and metalloprotemase domain 9 141

430044 AA464510 Hs 152812 EST cluster (not in UniGene) 141

429663 M68874 Hs 211587 Human phosphatidylcholme 2-acylhydrolase (cP 141

427036 AA397625 Hs 163913 ESTs 141

444381 BE387335 Hs 283713 ESTs 141

432090 AW972855 Hs 292853 ESTs 140

406778 H06273 Hs 101651 Homo sapiens mRNA, cDNA DKFZp434C107 (from cl 140

404961 AW972195 Hs 284236 aldo-keto reductase family 7, member A3 (afla 140

452313 Y00486 Hs 28914 adenine phosphoπbosyltransferase 140

452355 N54926 Hs 29202 G protein-coupled receptor 34 140

429942 AI338993 Hs 134535 ESTs 140

403165 0 13 9

442150 AI368158 Hs 128864 ESTs 139

439709 AW401433 Hs 6649 hypothetical protein FLJ20128 139

456799 AC004923 Hs 135187 Homo sapiens clone CDABP0025 mRNA sequence 139

427356 AW023482 Hs 97849 ESTs 139

448982 A1638164 Hs 225520 ESTs 139

432025 BE407132 Hs 111286 hypothetical protein FU22512 138

427505 AA361562 Hs 178761 26S proteasome associated padl homolog 138

402965 0 138

418601 AA279490 Hs 86368 calmegm 13 8

436954 AA740151 Hs 130425 ESTs 138

405024 0 138

453976 BE463830 Hs 163714 ESTs 138

431921 N46466 Hs 58879 ESTs 138

401735 0 138

445496 AB007860 Hs 12802 development and differentiation enhancing fac 138

425007 AA456483 Hs 172081 phosphodiesterase 4D, cAMP-specific (dunce (D 137

409463 AI458165 Hs 17296 ESTs 137

430193 AI826653 Hs 102928 Homo sapiens cDNA FU13479 fis, clone PLACE10 137

458869 AI637934 Hs 224978 ESTs 137

426769 AA075596 Hs 172153 glutathione peroxidase 3 (plasma) 137

416661 AA634543 Hs 79440 IGF-II mRNA-b ding protein 3 137 439901 N73885 Hs 124169 ESTs 137

431374 BE258532 Hs 251871 CTP synthase 137

432861 AA339526 Hs 279593 HSPC171 protein 137

441172 AI279652 Hs 132879 ESTs 137

410001 AB041036 Hs 57771 kallikrein 11, seπne protease (TLSP) 137

430315 NM 004293 Hs 239147 guanine deammase 136

422769 AA938905 Hs 289112 CGI43 protein 136

402389 0 136

448977 X91809 Hs 22698 regulator of G-protein signalling 19 136

459648 gb IL3-CT0220-150200 070-B02 CT0220 Homo sapi 136

452972 M31732 Hs 31210 B-cell CLL/lymphoma 3 136

431441 U81961 Hs 2794 sodium channel, nonvoltage-gated 1 alpha 136

448585 AB020676 Hs 21543 KIAA0869 protein 136

428385 AF112213 Hs 184062 putative Rab5-interacting protein 136

434699 AA643687 Hs 149425 Homo sapiens cDNA FU11980 fis, clone HEMBB10 136

447238 AW451676 Hs 158564 ESTs 13 6

437108 AA434054 Hs 80624 Homo sapiens cDNA FLJ23442 fis, clone HSI009 13 6

425749 AW328587 Hs 159448 surfeit 2 135

425154 NM 001851 Hs 154850 collagen, type IX, alpha 1 135

413753 U17760 Hs 301103 Laminin, beta 3 (nicein (125kD), kalinm (140 135

419034 NM.002110 Hs 89555 he opoietic cell kinase 135

448361 H82028 Hs 238707 Homo sapiens cDNA FLJ22457 fis, clone HRC099 135

412754 AW160375 Hs 74565 amyloid beta (A4) precursor-like protein 1 135

419081 AI798863 Hs 87191 ESTs 135

407732 AW138839 Hs 24210 ESTs 135

423329 AF054910 Hs 127111 tektin 2 (testicular) 135

422627 BE336857 Hs 118787 transforming growth factor, beta-induced, 68k 134

439636 AF086467 gb Homo sapiens full length insert cDNA clone 134

417605 AF006609 Hs 82294 regulator of G-protein signalling 3 134

445861 BE293423 Hs 11809 single Ig IL-1R-related molecule 134

447350 AI375572 Hs 172634 ESTs, HER4 (c-erb-B4) 134

451807 W52854 Hs 27099 DKFZP564J0863 protein 134

421515 Y11339 Hs 105352 GalNAc alpha-2, 6-sιalyltransferase I, long f 134

422443 NM 014707 Hs 116753 histone deacetylase 7B 134

412504 Z44496 Hs 26039 Homo sapiens cDNA FLJ13937 fis, clone Y79AA10 134

453344 BE349075 Hs 44571 ESTs 134

402885 0 134

438712 AW978161 Hs 169877 ESTs 134

421774 AL050374 Hs 108169 DKFZP586C1619 protein 13 3

425638 NM.012337 Hs 158450 nasopharyngeal epithelium specific protein 1 133

401897 0 133

425601 AW629485 Hs 293352 ESTs 133

450779 AW204145 Hs 156044 ESTs 133

444858 AI199738 Hs 208275 ESTs, Weakly similar to unnamed protein produ 133

442619 AA447492 Hs 20183 ESTs, Weakly similarto AF164793 1 protein x 133

434263 N34895 Hs 44648 ESTs 133

426059 BE292842 Hs 166120 interferon regulatory factor 7 133

407467 D55638 gb Human B-cell PABL (pseudoautosomal boundar 133

412560 R24601 Hs 108300 CCR4-NOT transcnption complex, subunit 3 132

442986 AI025990 Hs 285520 ESTs 132

420317 AB006628 Hs 96485 KIAA0290 protein 13 2

443211 AI128388 Hs 143655 ESTs 13 2

434361 AF129755 Hs 117772 ESTs 132

423493 AI815965 Hs 129683 ubiquitin-conjugating enzyme E2D 1 (homologou 132

414183 AW957446 Hs 301711 ESTs 132

447778 BE620592 Hs 71190 ESTs 132

435106 AA100847 Hs 193380 ESTs, Highly similar to AF174600 1 F-box prot 13 1

439490 AW249197 Hs 100043 ESTs, Weakly similar to PSF.HUMAN PTB-ASSOCIA 131

409606 AW444594 Hs 2387 transglutammase 4 (prostate) 131

421308 AA687322 Hs 192843 ESTs 131

414950 C15407 gb C15407 Clontech human aorta polyA+ mRNA (6 131

416783 AA206186 Hs 79889 monocyte to macrophage differentiation-associ 131

415927 AL120168 Hs 78919 Kell blood group precursor (McLeod phenotype) 131

422605 H16646 Hs 118666 Human clone 23759 mRNA, partial eds 130

430427 AA296701 Hs 241413 opticm 130

424620 AA101043 Hs 151254 kallikrein 7 (chymotryptic, stratum comeum) 130

421693 X71490 Hs 106876 ATPase, H+ transporting, lysosomal (vacuolar 130

407727 AW411148 Hs 38044 DKFZP564M082 protein 130

427706 AW971225 Hs 293800 ESTs, Weakly similar to ALU1.HUMAN ALU SUBFAM 130

406709 AI355761 Hs 242463 keratin 8 130

405353 0 130

453060 AW294092 Hs 21594 ESTs 130

459299 BE094291 Hs 155651 hepatocyte nuclear factor 3, beta 130

447843 AW337186 Hs 224891 ESTs 130

446576 AI659477 Hs 51820 ESTs, Moderately similar to ALU7.HUMAN ALU SU 130

449700 L02867 Hs 78358 ESTs 130

436476 AA326108 Hs 53631 ESTs 130

432532 AW058459 Hs 162246 ESTs 130

408405 AK001332 Hs 44672 hypothetical protein FU10470 13 0

432673 AB028859 Hs 278605 ER-associated DNAJ, ER-associated Hsp40 co-ch 129

414684 AW630023 Hs 76893 3-hydroxybutyrate dehydrogenase (heart, mitoc 129

447210 AF035269 Hs 17752 phosphatidylseπne-speαfic phospholipase A1 a 129

427923 AW274357 Hs 268384 Fzr1 protein 129

437395 AL365408 Hs 10632 hypothetical protein DKFZp762M136 129 441627 AA947552 Hs.58086 ESTs 12.9

419084 AA496539 Hs.179902 transporter-like protein 12.9

423067 AA321355 Hs.285401 ESTs 12.9

423070 R55677 Hs.155569 ESTs 12.8

441344 BE250144 Hs.41514 ESTs 12.8

423527 AI206965 Hs.105861 Homo sapiens cDNA FLJ13824 fis, clone THYRO10 12.8

417006 AW673606 Hs.80758 aspartyl-tRNA synthetase 12.8

453552 AL041941 Hs.154729 3-phosphoinositide dependent protein kiπase-1 12.8

453657 W23237 Hs.296162 ESTs 12.8

434414 AI798376 gb:fr34b07.x1 NCI_CGAP_Ov23 Homo sapiens cDNA 12.7

456051 T85626 Hs.76239 hypothetical protein FU20608 12.7

451659 BE379761 Hs.14248 ESTs, Weakly similar to ALU8.HUMAN ALU SUBFAM 12.7

418216 AA662240 Hs.283099 AF15q14 protein 12.7

423281 AJ271684 Hs.126355 C-type (calcium dependent, carbohydrate-recog 12.7

424275 AW673173 Hs.144505 DKFZP566F0546 protein 12.7

440062 AI350518 Hs.129692 ESTs 12.7

444371 BE540274 Hs.239 Forkhead box M1 12.7

412520 AA442324 Hs.795 H2A histone family, member O 12.7

413349 BE086692 gb:QV1-BT0678-130400-156-g07 BT0678 Homo sapi 12.7

414500 W24087 Hs.76285 DKFZP564B167 protein 12.6

429261 AW176254 Hs.143475 ESTs 12.6

402238 0 12.6

400280 0 12.6

421246 AW582962 Hs.300961 ESTs, Highly similar to AF151805 1 CGI47 pro 12.6

442029 AW956698 Hs.14456 neural precursor cell expressed, developmenta 12.6

435502 L13266 Hs.105 glutamate receptor, ionotropic, N-methyl D-as 12.6

409964 AW368226 Hs.67928 ESTs 12.6

418793 AW382987 Hs.88474 prostaglandin-endoperaxide synthase 1 (prosta 12.5

452117 AI421760 Hs.77870 Homo sapiens cDNA FU12750 fis, clone NT2RP20 12.5

448074 BE621355 Hs.27160 ESTs 12.5

442655 AW027457 Hs.30323 ESTs 12.5

409928 AL137163 Hs.57549 hypothetical protein dJ473B4 12.5

400240 0 12.5

413048 M93221 Hs.75182 mannose receptor, C type 1 12.5

426215 AW963419 Hs.155223 ESTs 12.5

430024 AI808780 Hs.227730 integrin, alpha 6 12.5

445655 AA873830 Hs.167746 B cell linker protein 12.5

419941 X98654 Hs.93837 phosphatidylinositol transfer protein, membra 12.5

425280 U31519 Hs.1872 phosphoenolpyruvate carboxykiπase 1 (soluble) 12.5

427767 AI879283 Hs.180714 cytochrome c oxidase subunit Via polypeptide 12.4

450243 AW119084 Hs.201037 ESTs 12.4

408930 AA146721 Hs.49005 hypothetical protein 12.4

418783 T41368 gb:ph1d1 19/1 TV Outward Alu-primed hncDNA lib 12.4

452096 BE394901 Hs.226785 ESTs 12.4

424513 BE385864 Hs.149894 mitochondrial translational initiation factor 12.4

422306 BE044325 Hs.227280 Homo sapiens mRNA for Lsm5 protein 12.4

409031 AA376836 Hs.76728 ESTs 12.4

435515 N40080 Hs.6879 DC13 protein 12.4

429583 NM.006412 Hs.209119 1-acylglycerol-3-phosphate O-acyltransferase 12.3

449643 R05989 Hs.19603 ESTs 12.3

440313 AL050060 Hs.7158 DKFZP566H073 protein 12.3

425593 AA278921 Hs.1908 proteoglycan 1, secretory granule 12.3

447357 AI375922 Hs.159367 ESTs 12.3

405089 0 12.3

414972 BE263782 Hs.77695 KIAA0008 gene product 12.3

435039 AW043921 Hs.130526 ESTs 12.3

447033 AI357412 Hs.157601 EST- notin UniGene 12.3

427521 AW973352 Hs.299056 ESTs 12.3

409377 AA300274 Hs.115659 Homo sapiens cDNA: FU23461 fis, clone HSI077 12.3

400116 0 12.3

445806 AL137516 Hs.13323 hypothetical protein FLJ22059 12.2

457817 AA247751 Hs.79572 cathepsiπ D (lysosomal aspartyl protease) 12.2

442410 AW996503 Hs.197680 ESTs 12.2

445404 AI261687 Hs.145541 ESTs, Weakly similar to JC4974 sodium iodide 12.2

403372 AW249152 Hs.44017 SIR2 (silent mating type information regulati 12.2

427082 AB037858 Hs.173484 hypothetical protein FU 10337 12.2

433764 AW753676 Hs.39982 ESTs 12.2

400268 0 12.2

433190 M26901 Hs.3210 renin 12.2

444863 AW384082 Hs.301323 ESTs 12.2

434779 AF153815 Hs.50151 potassium inwardly-rectifying channel, subfam 12.2

451346 NMJ06338 Hs.26312 glioma amplified on chromosome 1 protein (leu 12.2

430262 AA218780 Hs.237323 N-acetylglucosamine-phosphate mutase 12.2

421071 AI311238 Hs.104476 ESTs 12.2

426773 NMJ15556 Hs.172180 KIAA0440 protein 12.1

409178 BE393948 Hs.50915 kallikrein 5 12.1

400250 0 12.1

428450 NM 014791 Hs.184339 KIAA0175 gene product 12.1

414531 T69387 Hs.76364 allograft inflammatory factor 1 12.1

448210 AW247775 Hs.7393 hypothetical protein from EUROIMAGE 1987170 12.1

440081 AA863389 Hs.135643 ESTs 12.1

413179 N99692 Hs.75227 NADH dehydrogenase (ubiquinone) 1 alpha subco 12.1

447551 BE066634 Hs.929 myosin, heavy polypeptide 7, cardiac muscle, 12.1

400517 AF242388 Hs.149585 lengsin 12.1 401610 0 12.0

454381 AI935093 Hs.193428 ESTs 12.0

443997 AW081465 Hs.299644 ESTs 12.0

402944 0 12.0

430637 BE160081 Hs.256290 S100 calcium-binding protein A11 (calgizzarin 12.0

415099 AI492170 Hs.77917 ubiquitin carboxyl-terminal esterase L3 (ubiq 12.0

445422 AV653731 Hs.282829 ESTs 12.0

416667 AK000526 Hs.79457 hypothetical protein FU20519 12.0

442611 BE077155 Hs.177537 ESTs 12.0

443271 BE568568 Hs.195704 ESTs 12.0

415120 N64464 Hs.34950 ESTs 12.0

439574 AI469788 Hs.165190 ESTs 12.0

405804 0 12.0

412519 AA196241 Hs.73980 troponin TI, skeletal, slow . 12.0

414135 NM 004419 Hs.2128 dual specificity phosphatase 5 12.0

447075 AV662037 Hs.124740 ESTs 12.0

416841 N33878 Hs.249495 heterogeneous nuclear ribonucleoprotein A1 12.0

402943 0 11.9

416933 BE561850 Hs.80506 small nuclear ribonucleoprotein polypeptide A 11.9

439744 AL389994 Hs.301272 ESTs, Weakly similar to homologue of Drosphil 11.9

405762 0 11.9

408983 NM.000492 Hs.663 cystic fibrosis transmembrane conductance reg 11.9

455102 BE005496 gb:CM1-BN0117-110400-183-b09 BN0117 Homo sapi 11.9

402840 0 11.9

449183 AW445022 Hs.196985 Homo sapiens cDNA: FU21135 fis, clone CAS072 11.9

439273 AW139099 Hs.269701 ESTs 11.9

450484 BE220675 gb:ht98f11.x1 NCI_CGAP_Lu24 Homo sapiens cDNA 11.9

445431 AF137386 Hs.12701 plasmolipin 11.9

401888 0 11.9

426037 AW160780 Hs.166071 cyclin-dependent kinase 5 11.9

416742 R38644 Hs.248420 ESTs 11.9

418324 AW246273 Hs.84131 threonyl-tRNA synthetase 11.8

412870 N22788 Hs.82407 Homo sapiens HSPC296 mRNA, partial eds 11.8

432680 T47364 Hs.278613 interferon, alpha-inducible protein 27 11.8

421478 AI683243 Hs.97258 ESTs 11.8

426635 BE395109 Hs.129327 ESTs 11.8

420523 AA262999 Hs.42788 ESTs 11.8

426227 U67058 Hs.168102 Human prateinase activated receptor-2 mRNA; 3 11.8

416658 U03272 Hs.79432 fibrillin 2 (congenital contractural arachnod 11.8

441816 AI401807 Hs.149997 ESTs 11.8

424596 AB020639 Hs.151017 estrogen-related receptor gamma 11.8

400640 0 11.8

448133 AA723157 Hs.73769 folate receptor 1 (adult) 11.8

401532 0 11.8

400161 0 11.8

442556 AL137761 Hs.8379 Homo sapiens mRNA; cDNA DKFZp586L2424 (from c 11.7

451002 AA013299 Hs.8018 ESTs, Weakly similar to ALU3 HUMAN ALU SUBFAM 11.7

401879 0 11.7

415989 AI267700 Hs.111128 ESTs 11.7

416434 AW163045 Hs.79334 nuclear factor, interieukiπ 3 regulated 11.7

410616 AW873401 Hs.273599 ESTs 11.7

449239 T24653 Hs.23360 likely ortholog of yeast ARV1 11.7

447669 AL049985 Hs.19180 Homo sapiens mRNA; cDNA DKFZp564E122 (from cl 11.7

436877 AA931484 Hs.121255 ESTs, Weakly similar to cDNA EST EMBLD67419 11.7

434560 R13052 Hs.3964 Homo sapiens clone 24877 mRNA sequence 11.7

448105 AW591433 Hs.170675 ESTs, Weakly similar to TMS2 HUMAN TRANSMEMBR 11.7

400279 0 11.6

440497 AA887266 Hs.144979 ESTs 11.6

451260 AW750773 gb:CMO-CN0044-260100-164-h03 CN0044 Homo sapi 11.6

429175 AI953040 Hs.127714 ESTs, Moderately similar to SOX30 protein [H. 11.6

408209 NM 004454 Hs.43697 ets variant gene 5 (ets-related molecule) 11.6

428856 AA436735 Hs.183171 Homo sapiens cDNA: FU22002 fis, clone HEP066 11.6

420153 N22120 Hs.75277 hypothetical protein FU13910 11.6

428760 AI351459 Hs.192398 ESTs 11.6

421401 AW410478 Hs.104019 transforming, acidic coiled-coil containing p 11.6

404502 0 11.6

430423 AI190548 Hs.143479 ESTs, Weakly similar to hypothetical protein 11.6

405192 0 11.6

439092 AA830149 gb:oc44f08.s1 NCI CGAP GCB1 Homo sapiens cDNA 11.6

401714 0 11.5

439335 AA742697 Hs.62492 ESTs, Weakly similar to S59856 collagen alpha 11.5

406082 S47833 Hs.82927 adenosine monophosphate deaminase 2 (isoform 11.5

401010 0 11.5

412140 AA219691 Hs.73625 RAB6 interacting, kinesin-like (rabkinesinδ) 11.5

409339 AB020686 Hs.54037 ectonucleotide pyrophosphatase/phosphodiester 11.5

459684 gb:ao86a08.x1 Schiller meπingioma Homo sapien 11.5

451051 BE254309 Hs.125262 DKFZP586G1624 protein 11.5

415323 BE269352 Hs.949 neufrophil cytosolic factor 2 (65kD, chronic 11.5

412153 R87934 gb:yo47b10.r1 Soares adult brain N2b4HB55Y Ho 11.5

427256 AL042436 Hs.97723 ESTs 11.5

406708 AI282759 Hs.242463 keratin 8 11.4

457644 AA770080 Hs.144962 ESTs, Moderately similar to I59365 ubiquitin 11.4

422848 Z25884 Hs.121483 chloride channel 1 , skeletal muscle (Thomsen 11.4

424134 AF070637 Hs.140950 hypothetical protein 11.4 451931 AK000208 Hs.27267 Homo sapiens cDNA FU20201 fis, clone COLF121 11.4

400438 AF185611 Hs.115352 growth hormone 1 11.4

412994 D32257 Hs.75113 general transcription factor IIIA 11.4

408124 U89337 Hs.42853 cAMP responsive element binding protein-like 11.4

452249 BE394412 Hs.61252 ESTs 11.4

424627 AA344555 gb:EST50715 Gall bladder I Homo sapiens cDNA 11.4

405626 0 11.4

436690 AA373970 Hs.183096 ESTs 11.4

415862 R51034 Hs.144513 ESTs 11.4

406755 N80129 Hs.94360 metallothionein 1L 11.4

433657 AI244368 Hs.8124 PH domain containing protein in retina 1 11.4

429612 AF062649 Hs.252587 pituitary tumor-transforming 1 11.4

423334 AK000906 Hs.127273 hypothetical protein FU10044 11.4

433053 BE301909 Hs.279952 glutathione S-fransferase subunit 13 homolog 11.4

428423 AU076517 Hs.184276 solute carrier family 9 (sodium/hydrogen exch 11.3

442353 BE379594 Hs.49136 ESTs 11.3

447700 AI420183 Hs.171077 ESTs, Weakly similar to similar to serine/thr 11.3

402077 0 11.3

409203 AA780473 Hs.687 cytochrome P450, subfamily IVB, polypeptide 1 11.3

405145 0 11.3

428248 AI126772 Hs.40479 ESTs 11.3

425508 AA991551 Hs.97013 ESTs 11.3

428340 AF261088 Hs.154721 aconitase 1, soluble 11.3

431452 AI073641 Hs.152372 ESTs 11.3

446651 AA393907 Hs.97179 ESTs 11.3

443755 C18397 Hs.9730 tachykinin 3 (neuromedin K, neurokinin beta) 11.3

436209 AW850417 Hs.254020 ESTs, Moderately similarto unnamed protein p 11.3

401020 0 11.3

456724 AW247388 Hs.301423 calcium binding protein 1 (calbrain) 11.2

407227 H94949 Hs.171955 trophiπin associated protein (tastin) 11.2

402066 0 11.2

442721 AI015892 Hs.101282 Homo sapiens mRNA; cDNA DKFZp434B102 (from cl 11.2

401025 0 11.2

452423 AA991724 Hs.180535 Homo sapiens cDNA: FLJ22711 fis, clone HSU 33 11.2

431685 AW296135 Hs.267659 vav 3 oncogene 11.2

425176 AW015644 Hs.301430 ESTs, Moderately similar to TEF1.HUMAN TRANSC 11.2

435496 AW840171 Hs.265398 ESTs, Weakly similar to transformation-relate 11.2

409079 W87707 Hs.82065 interleukin 6 signal transducer (gp130; oncos 11.2

456995 T89832 Hs.170278 ESTs 11.2

419223 X60111 Hs.1244 CD9 antigen (p24) 11.2

407788 BE514982 Hs.38991 S100 calcium-binding protein A2 11.2

407604 AW191962 Hs.288061 actin, beta 11.2

437929 T09353 Hs.106642 ESTs, Weakly similar to hypothetical protein 11.1

415789 H01581 gb:yj33f08.r1 Soares placenta Nb2HP Homo sapi 11.1

424447 AL137376 Hs.147368 Homo sapiens mRNA; cDNA DKFZp434J0226 (from c 11.1

436034 AF282693 Hs.150185 inflammation-related G protein-coupled recept 11.1

404931 0 11.1

445979 AI695047 Hs.202395 ESTs 11.1

446733 AA863360 Hs.26040 ESTs; Highly similarto CYTOCHROME P45 IVA2 11.1

433133 A8027249 Hs.104741 PDZ-binding kinase; T-cell originated protein 11.1

445258 AI635931 Hs.147613 ESTs 11.1

417251 AW015242 Hs.99488 ESTs; Weakly similar to ORF YKR074w [S.cerevi 11.1

421041 N36914 Hs.14691 ESTs 11.1

425537 AB007913 Hs.158291 KIAA0444 protein 11.1

435763 AI243929 Hs.190419 ESTs 11.1

444790 - AB030506 Hs.11955 B9 protein 11.1

453857 AL080235 Hs.35861 DKFZP586E1621 protein 11.1

433882 U90441 Hs.3622 procollagen-proline, 2-oxoglutarate 4-dioxyge 11.1

405358 0 11.1

435814 AW615179 Hs.152870 ESTs 11.0

422809 AK001379 Hs.121028 hypothetical protein FU 10549 11.0

446772 AW294404 Hs.144515 Homo sapiens cDNA FU11672 fis, clone HEMBA10 11.0

456694 AW016382 Hs.105642 Homo sapiens cDNA: FLJ23271 fis, clone HEP001 11.0

441128 AA570256 Hs.54628 ESTs 11.0

432677 NM 004482 Hs.278611 UDP-N-acetyl-alpha-D-galactosamine:polypeptid 11.0

412576 AA447718 Hs.107057 ESTs 11.0

411122 F00809 Hs.143696 coxtivator-associated arginine methyltransfe 11.0

427225 AA432391 Hs.258903 Homo sapiens mRNA for KIAA1640 protein, parti 11.0

426260 NM 002541 Hs.168669 oxoglutarate dehydrogenase (lipoamide) 11.0

444652 BE513613 Hs.11538 actin related protein 2/3 complex, subunit 1 A 11.0

431947 AL359613 Hs.49933 hypothetical protein DKFZp762D1011 11.0

414432 BE378174 Hs.26506 Homo sapiens clone CDABP0005 mRNA sequence 11.0

458627 AW088642 Hs.97984 ESTs; Weakly similarto WASP-family protein [ 10.9

409142 AL136877 Hs.50758 chromosome-associated polypeptide C 10.9

447627 AF090922 Hs.285902 CGI-113 protein 10.9

447656 NM 003726 Hs.19126 src kiπase-associated phosphoprotein of 55 kD 10.9

454227 AW963897 Hs.44743 KIAA1435 protein 10.9

402927 0 10.9

422380 AA309881 Hs.136246 ESTs 10.9

455986 BE177736 gb:RC1-HT0598-140300-021-g06 HT0598 Homo sapi 10.9

410962 BE273749 Hs.752 FK506-binding protein 1A (12kD) 10.9

450361 BE327108 Hs.202512 ESTs 10.9

457484 H57645 gb:yr21e01.r1 Soares fetal liver spleen 1 NFLS 10.9

407903 AI287341 Hs.154029 . bHLH factor Hes4 10.9 403398 0 109

401405 0 109

405570 0 109

421240 R72730 Hs 29283 ESTs, Weakly similarto PLK HUMAN PROTEOGLYCA 109

403649 0 109

447824 BE6208C0 gb 601483379T1 NIH.MGC.69 Homo sapiens cDNAc 109

450935 BE514743 Hs 25664 tumor suppressor deleted in oral cancer-relat 109

439853 AL119566 Hs 6721 lysophospholφase-like 109

451852 R51928 gb yj71c05 r1 Soares breast 2NbHBst Homo sapi I09

431218 NM 002145 Hs 2733 homeo box B2 109

457794 AA689292 Hs 246850 ESTs 109

444374 AA009841 Hs 11039 Homo sapiens cDNA FLJ12798 fis, clone NT2RP20 109

456566 AW235317 Hs 259214 ESTs 108

405552 0 108

439436 BE140845 Hs 57868 ESTs 108

435310 AA705075 Hs 169536 Rhesus blood group-associated glycoprotein 108

411125 AA151647 Hs 68877 cytochrome b-245, alpha polypeptide 108

415807 H03139 Hs 24683 ESTs 108

409430 R21845 Hs 166975 splicing factor, argmine/seπne-πch 5 10 B

417033 H83784 Hs 40532 ESTs, Weakly similar to PEBP MOUSE PHOSPHATID 108

418464 R87580 gb ym89h07 r1 Soares adult brain N2b4HB55Y Ho 10 8

404567 0 10 8

418384 AW149266 Hs 25130 ESTs 108

421971 U63127 Hs 110121 SEC7 homolog 108

428769 AW207175 Hs 106771 ESTs 108

459104 R19238 Hs 282057 ESTs 108

410896 AW809637 gb MR4-ST0124-261099-015-b07 ST0124 Homo sapi 108

416969 AI815443 Hs 283404 organic cation transporter 108

408796 AA688292 Hs 118553 ESTs 108

426298 AW965058 Hs 111583 ESTs 108

421595 AB014520 Hs 105958 Homo sapiens cDNA FLJ22735 fis, clone HUV001 108

408007 AW135965 Hs 246783 ESTs 108

400167 0 107

445243 AI217439 Hs 109854 ESTs, Weakly similar to ALU1.HUMAN ALU SUBFAM 107

421733 AL119671 Hs 1420 fibroblast growth factor receptor 3 (achoπdro 10 7

412241 AW948343 gb RC0-MT0015-130400 031-c01 MT0015 Homo sapi 107

425827 W28316 gb 45b6 Human retina cDNA randomly pπmed sub 107

420255 NM 007289 Hs 1298 membrane metallo-endopeptidase (neutral endop 107

430891 U22492 Hs 248118 G protein-coupled receptor 8 107

402883 0 10 7

423811 AW299598 Hs 50895 homeo box C4 107

447078 AW885727 Hs 301570 ESTs 107

414343 AL036166 Hs 75914 coated vesicle membrane protein 107

446913 AA430650 Hs 16529 transmembrane 4 superfamily member (tetraspan 107

452279 AA286844 Hs 61260 hypothetical protein FU13164 107

401220 0 107

459259 AJ003294 gb AJ003294 Selected chromosome 21 cDNA libra 107

414171 AA360328 Hs 865 RAP1 A, member of RAS oncogene family 107

448449 BE314567 Hs 211440 ESTs 107

429670 L01087 Hs 211593 protein kinase C, theta 107

446759 R61463 Hs 16165 expressed in activated T/LAK lymphocytes 107

400776 0 107

428093 AW594506 Hs 104830 ESTs 107

412801 AA121055 gb zm22b01 r1 Stratagene pancreas (937208) Ho 106

440545 AW183201 Hs 190559 ESTs 106

434540 NM.016045 Hs 5184 TH1 drosophila homolog 106

414273 BE269057 gb 601184231F1 NIH MGC 8 Homo sapiens cDNAcI 106

401817 0 106

410423 AW402432 Hs 63489 protein tyrosine phosphatase, non receptor ty 106

430590 AW383947 Hs 246381 CD68 antigen 106

426680 AA320160 Hs 171811 adenylate kinase 2 10 6

445413 AA151342 Hs 12677 CGI-147 protein 106

402947 0 106

457426 AW971119 gb EST383206 MAGE resequences, MAGL Homo sapi 106

424148 BE242274 Hs 1741 mtegπn, beta 7 106

404944 0 106

405421 0 106

416772 AI733872 Hs 79769 pratocadheπn 1 (cadheπn like 1) 106

414191 AW250089 Hs 75807 PDZ and UM domain 1 (elfin) 106

457588 AI571225 Hs 284171 KIAA1535 protein 106

406038 Y14443 Hs 88219 zinc finger protein 200 106

404790 0 106

418922 AW956580 Hs 42699 Thrambospondιn-1 (Hs 87409) 106

425940 AB023184 Hs 163990 KIAA0967 protein 106

448749 AW859679 Hs 21902 Homo sapiens clone 25237 mRNA sequence 106

418870 AF147204 Hs 89414 CXCR4, chemoktne CXC receptor 4 (fusm) 105

417933 X02308 Hs 82962 thymidylate synthetase 105

450538 AW297396 Hs 227052 ESTs 105

427928 AA417662 Hs 119217 ESTs 105

432721 AL121478 Hs 3132 steroidogemc acute regulatory protein 105

429267 AA299290 Hs 246857 ESTs, Highly similar to S71100 protein kinase 105

439190 AW978693 Hs 293811 ESTs 105

408975 AW958693 Hs 49391 hypothetical protein LOC54149 105

415130 W85893 Hs 249867 ESTs 10 5 425738 H29630 Hs 159408 Homo sapiens clone 24420 mRNA sequence 105

440232 A1766925 Hs 112554 ESTs 10 5

425065 AA371906 Hs 294151 ESTs, Moderately similar to KIAA0544 protein 10 5

420829 AW665612 Hs 221969 ESTs 10 5

430466 AF052573 Hs 241517 polymerase (DNA directed), theta 10 5

407771 AL138272 Hs 62713 ESTs 105

444611 AK002180 Hs 11449 DKFZP5640123 protein 10 5

444665 BE613126 Hs 47783 ESTs, Weakly similar to T12540 hypothetical p 10 5

448030 N30714 Hs 20161 HDCME31P protein 10 5

438982 AW979101 Hs 291980 ESTs 10 5

446224 AW450551 Hs 13308 ESTs 10 5

405108 0 105

438233 W52448 Hs 56147 ESTs 105

401799 0 105

454038 X06374 Hs 37040 platelet-deπved growth factor alpha polypept 105

414222 AL135173 Hs 878 sorbitol dehydrogenase 105

421828 AW891965 Hs 289109 dimethylargiπme dimethylaminohydrolase 1 105

422626 AA344932 Hs 118786 metallothionem 2A 105

449261 AI637592 Hs 224958 ESTs 104

416218 R21499 Hs 23213 ESTs 104

457848 W26524 Hs 125682 ESTs, Weakly similar to D20922 [C elegans] 104

442577 AA292998 Hs 163900 ESTs 104

406505 AF016272 Hs 115418 cadheπn 16, KSP-cadheπn 104

412258 AA376768 Hs 288977 Homo sapiens cDNA FU22622 fis, clone HSI056 104

429224 AI905780 Hs 198272 NADH dehydrogenase (ubiqumone) 1 beta subcom 104

447774 BE018118 Hs 19554 chromosome 1 open reading frame 2 104

403914 0 104

406329 0 104

402423 0 104

431986 AA536130 Hs 149018 ESTs 104

423145 BE264548 Hs 222190 ESTs, Weakly similar to secretory earner mem 104

414402 BE294186 gb 601172959F1 NIH.MGC.17 Homo sapiens cDNA c 104

417079 U65590 Hs 81134 interteukin 1 receptor antagonist 104

426095 AI278023 Hs 89986 ESTs 104

434577 R37316 Hs 179769 Homo sapiens cDNA FU22487 fis, clone HRC109 104

442415 AI005101 Hs 129550 ESTs 103

421506 BE302796 Hs 105097 thymidine kinase 1, soluble 103

435084 D17516 Hs 301607 adenylate cyclase activating polypeptide 1 (p 103

431724 AA514535 Hs 283704 ESTs 103

456798 AJ006422 Hs 135183 centauπn-alpha 103

417370 T28651 Hs 82030 fryptophanyl-tRNA synthetase 103

422596 AF063611 Hs 118633 2'-5'olιgoadenylate synthetase like 103

435226 AI248938 Hs 270106 ESTs 103

433192 AB040880 Hs 225594 ESTs, Moderately similar to KIAA1447 protein 103

419879 Z17805 Hs 93564 Homer, neuronal immediate early gene, 2 103

416228 AW505190 Hs 79089 sema domain, immunoglobulin domain (Ig), tran 103

453403 BE466639 Hs 61779 Homo sapiens cDNA FU13591 fis, clone PLACE10 10 3

447906 AL050062 Hs 19999 DKFZP566K023 protein 10 3

401782 NM 012434 Hs 117865 solute earner family 17 (anion/sugartranspo 103

453927 AA082465 Hs 301751 ESTs, Weakly similar to /prediction 103

450737 AW007152 Hs 203330 ESTs 103

421633 AF121860 Hs 106260 sorting nexin 10 10 3

409881 AF139799 Hs 202830 ESTs 103

432883 U48936 Hs 3112 sodium channel, nonvoltage-gated 1, gamma 10 3

440099 AL080058 Hs 6909 DKFZP564G202 protein 10 3

419024 X56411 Hs 1219 alcohol dehydrogenase 4 (class II), pi polype 10 3

401835 0 103

408896 AI610447 Hs 48778 niban protein 10 3

443120 AW402677 Hs 290801 ESTs 103

400208 0 102

416908 AA333990 Hs 80424 coagulation factor XIII, A1 polypeptide 102

400166 0 102

434642 W25739 Hs 135287 ESTs 102

424837 BE276113 Hs 153436 N-acetyltransferase, homolog of S cerevisiae 102

435075 R51094 Hs 12400 ESTs 102

425912 AL137629 Hs 162189 senπe/threonme kinase with Dbl- and pleckst 102

435080 AI831760 Hs 155111 ESTs 102

414998 NM.002543 Hs 77729 oxidised low density lipoprotein (lectm like 102

410020 T86315 Hs 728 πbonuclease, RNase A family, 2 (liver, eosm 102

411410 R20693 Hs 69954 laminin, gamma 3 10 2

450294 H42587 Hs 238730 ESTs 10 2

421154 AA284333 Hs 287631 Homo sapiens cDNA FU14269 fis, clone PLACE10 10 2

414271 AK000275 Hs 75871 protein kinase C binding protein 1 10 2

400812 0 10 2

425843 BE313280 Hs 159627 death associated protein 3 102

449392 Z41698 Hs 26039 Homo sapiens cDNA FU 13937 fis, clone Y79AA10 102

409089 NM.014781 Hs 50421 KIAA0203 gene product 102

401383 0 10 2

456855 AF035528 Hs 153863 MAD (mothers against decapentaplegic, Drosoph 102

442912 AI088060 Hs 131450 ESTs 102

400954 D25969 Hs 76325 Homo sapiens cDNA FU23125 fis, clone LNG082 102

401029 BE382701 Hs 25960 v myc avian myelocytomatosis viral related on 102

416602 NM 006159 Hs 79389 nel (chιcken)-lιke 2 102

421905 AI660247 Hs 32699 ESTs, Weakly similar to LIV-1 protein [H sapi 10 2 405094 0 102

450832 AW970602 Hs 105421 ESTs 102

440076 R32052 Hs 178617 ESTs, Weakly similar to AF151840 1 CGI 82 pro 10 2

447563 BE536115 Hs 160983 ESTs 10 2

421238 AB033101 Hs 102796 KIAA1275 protein 102

400882 0 102

415738 BE539367 Hs 295953 ESTs, Weakly similar to AF220049 1 uncharacte 101

445464 AW172389 Hs 249999 ESTs 10 1

459042 AW272058 Hs 210338 ESTs 10 1

414469 R51952 Hs 32587 steπod receptor RNA activator 1 (complexes w 101

434732 AI078443 gb oz05g05 x1 Soares_fetal_lιver_spleen_1NFLS 10 1

441030 AW204139 Hs 174424 ESTs, Weakly similarto p140mDιa [M musculus] 10 1

446855 BE616767 Hs 16269 B-cell CLL/lymphoma 7B 101

456785 AF151074 Hs 132744 hypothetical protein 101

404182 0 101

410358 AW975168 Hs 13337 ESTs, Weakly similar to unnamed protein produ 101

430355 NM.006219 Hs 239818 phosphoιπosιtιde-3 kinase, catalytic, beta po 101

442152 R39246 Hs 239666 Homo sapiens cDNA FU13495 fis, clone PLACE10 10 1

436354 AI879252 Hs 5151 Homo sapiens mRNA, cDNA DKFZp564C2163 (from c 10 1

426711 AA383471 Hs 180669 conserved gene amplified in osteosarcoma 10 1

450599 AA460865 Hs 48516 ESTs 101

454393 BE153288 gb PMO-HT0335-180400-008-C08 HT0335 Homo sapi 10 1

403383 0 101

415947 U04045 Hs 78934 mutS (E coli) homolog 2 (colon cancer, nonpo 101

411773 NM 006799 Hs 72026 protease, seππe, 21 (testisin) 101

412116 AW402166 Hs 784 Epstein Barr virus induced gene 2 (lymphocyte 10 1

413808 J00287 Hs 182183 caldesmon 1 100

458572 AI223423 Hs 292794 ESTs 100

403295 0 10 0

403910 0 10 0

453400 AI991901 Hs 82590 ESTs, Moderately similar to ALU7 HUMAN ALU SU 100

406502 0 100

404743 0 100

412517 BE271584 gb 601141065F1 NIH MGC 9 Homo sapiens cDNA cl 100

402679 0 10 0

455864 BE148970 gb CM0 HT0245-031199 085-h05 HT0245 Homo sapi 100

425734 AF056209 Hs 159396 peptidylglycme alpha amidatmg monooxygenase 100

419280 W07506 Hs 283725 Homo sapiens cDNA FLJ12627 fis clone NT2RM40 100

443503 AV645438 Hs 282927 ESTs 10 0

423165 AI937547 Hs 124915 Human DNA sequence from clone 380A1 on chromo 10 0

450206 AI796450 Hs 201600 ESTs 100

459052 AA298812 Hs 98539 ESTs 100

456248 AL035786 Hs 82425 actin related protein 2/3 complex, subunit 5 100

428438 NM 001955 Hs 2271 Endothelin 1 100

456525 AW468397 Hs 100000 S100 calcium binding protein A8 (calgranulm 100

426127 L36983 Hs 167013 dynamin 2 10 0

TABLE 13B

Pkey Unique Eos probeset identifier number CAT number Gene cluster number

Accession Genbank accession numbers

Pkey CAT Number Accession

410896 1226053.1 AW809637 AW809697 AW810554 AW809707 AW809885 AW810000 AW810088 AW809742 AW809816 AW809749 AW809639 AW809722

AW809836 AW809774 AW810023 AW810013 AW809813 AW809660 AW809728 AW809768 AW809951 AW809657 AW809954

412153 1279701 1 R87934 AW898205 AW896020 AW896035

412241 1284681 1 AW948343 AW948341 AW902855 AW984737

412517 130281 1 BE271584 AA112511

412801 132825 1 AA121055 AA330917

413349 1363558 1 BE086692 BE087077 BE087072

414273 1431911 1 BE269057 BE513434 BE396654

414402 1443240 1 BE294186 BE298975

414950 1509777.1 C15407 D81769 D61133

415789 1555357 1 H01581 H12850 R65905 H13053

416368 1591066 1 R88849 R84573 H50890

418464 1759038 2 R87580

418783 1789791 1 T41368 T41369 T41294

424627 241724 1 AA344555 AA344312 AW963070

425827 256834 1 W28316 W26507AA364334

434371 384839 1 AA631362 AA631438

434414 38585 1 AI798376 S46400 AW811617 AW811616 W00557 BE142245 AW858232 AW861851 AW858362 AA232351 AA218567 AA055556 AW858231

AW857541 AW814172 H66214 AW814398 AF134164 AA243093 AA173345 AA199942 AA223384 AA227092 AA227080 T12379 AA092174

T61139 AA149776 AA699829 AW879188 AW813567 AW813538 A1267168 AA157718 AA157719 AA100472 AA100774 AA130756 AA157705

AA157730 AA157715 AA053524 AW849581 AW854566 C05254 AW882836 T92637 AW812621 AA206583 AA209204 BE156909 AA226824

AI829309 AW991957 N66951 AA527374 H66215 AA045564 AI694265 H60808 AA149726 AW195620 BE081333 BE073424 AW817662

AW817705 AW817703 AW817659 BE081531 H59570

434732 392447 1 AI078443 AA648102 AI765577 AW974381

439092 468554 1 AA830149 AW978407 M85983 AW503637

439636 47467 1 AF086467W81444W81445

447824 73861 -1 BE620800

450484 83645 1 BE220675 AA345621 AA009992

451260 863912 1 AW750773AI768154

451852 888359 1 R51928 AI820698 R48360 AI820694

452101 898742.1 T60298 AI858257 T69667 T67634 T61224 T71537 T68933 454163 10483691 AW175997 AW176000 AW175999 AW175994 AW176004 AW175989

454393 1158881 BE153288 BE153151 BE152925AA078302

455102 12535241 BE005496 BE005494 AW856324 AW900199

455864 13770381 BE148970 BE148975 BE148957 BE148937

455986 1397521 1 BE177736 BE177735 BE177734

456423 187241 1 AW748920 AA487506 AA248914 AA780494

457426 3361891 AW971119 AA574265 AA513268

457484 3421131 H57645 T19302AA527038 Z24851 H93171

457705 3893831 AW974668 AA661959 AA649572 AA640401 AA640402

459259 9662691 AJ003294 AJ003315 AJ003293

TABLE 13C

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham I et al " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489495

Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons

Pkey Ref Strand NLposition

400640 8117686 Plus 144324-144429

400666 8118496 Plus 17982-18115,20297-20456

400776 8131651 Plus 103576-103720

400812 8568711 Plus 71708-72153

400881 2842777 Minus 91446-91603,92123-92265

400882 2842777 Minus 110431-110708

400965 7770576 Minus 173043-173564

401010 8117391 Minus 83967-84180

401020 8117458 Minus 59085-60227

401025 8117518 Minus 179287-179483,181044-181166,181844-182039

401047 6705887 Minus 4804-5035,5133-5314

401131 8699812 Minus 94802-94987,95804-95887,96323-96487,97596-97826

401192 9719502 Minus 69559-70101

401220 9929324 Minus 4807948279

401383 6721135 Minus 155543-157381

401405 7768126 Minus 69276-69452,69548-69958

401519 6649315 Plus 157315-157950

401532 7798785 Plus 124414-124950,125050-125418

401610 7705041 Minus 18921-19505

401714 6715702 Plus 96484-96681

401735 3252819 Plus 217235-217356,217621-217873

401799 7331447 Plus 147802-148251

401817 7417850 Minus 45888-46535

401835 7139700 Plus 142257-142742

401879 8099914 Minus 101064-102827

401888 8516069 Minus 189498-190514

401897 8569218 Plus 604-767

402066 6649269 Plus 135543-136031

402077 8117414 Plus 65014-65195

402104 8119072 Plus 122409-122600

402238 7690126 Plus 24726-24880,26791-27021

402287 4559317 Plus 40811-42447

402389 9885999 Minus 771-972,1571-1683

402408 9796239 Minus 110326-110491

402423 9796344 Minus 62487-62664

402424 9796344 Minus 64925-65073

402496 9797769 Minus 8615-9103

402520 7596899 Minus 171761-171996

402679 8113438 Plus 132079-132216

402840 9369121 Minus 57118-57306

402883 9926562 Plus 38666-38803,38885-39019,39097-39231,39308-39445

402885 9926751 Plus 71919-72049

402926 8217647 Minus 4126141443

402927 8217647 Minus 4724747396

402943 6456831 Plus 38467-39068

402944 9368423 Plus 110411-110716,111173-111640

402947 9368458 Minus 101629-101991

402965 9581599 Minus 4686546941,4703247148

403022 3132351 Plus 92097-92864

403121 9180223 Plus 40594258

403165 9838098 Minus 90595-91848

403295 8096528 Plus 22386-22708

403381 9438267 Minus 26009-26178

403383 9438267 Minus 119837-121197

403398 6862689 Minus 13685-14699

403399 6684178 Plus 61841-62145,62367-62756

403482 9966050 Plus 196964-197135

403485 9966528 Plus 2888-3001,3198-3532,36554117

403649 8705159 Minus 27141-27247

403910 7710710 Minus 5761-6188

403912 7710730 Minus 72000-72290,72431-72700,72929-73199

403914 7417588 Minus 7431-8472

404182 4775644 Plus 18163-18444

404502 7229863 Minus 56277-56819

404567 7249169 Minus 101320-101501 404678 9797204 Plus 115196-115448

404743 8894169 Minus 120556-120999

404780 9887810 Minus 175708-175871

404790 7230958 Plus 38611-38761

404931 7342203 Plus 44226-44382

404944 6899705 Plus 42564581

405024 7107727 Plus 88500-88697

405089 8072523 Plus 103182-103973

405094 8072579 Plus 135587-135758

405108 7107890 Minus 135020-135472

405145 9438278 Plus 37883-38052,38138-38332

405192 7230070 Plus 115629-116071

405224 6731245 Minus 14413-15979

405295 3818412 Plus 56933-57099

405353 2811095 Plus 118525-118892

405358 2341017 Minus 18016-18315

405421 7243869 Minus 97411-97687

405426 7243900 Minus 37640-37817

405452 7656638 Minus 93876-94275

405484 5922025 Plus 199214-199579,199672-199920,200262-200495

405552 1552506 Plus 4519945647

405570 2808656 Plus 98208-98331

405626 4508116 Minus 89275-89384,92450-92629,97091-97279,98546-98666

405699 4165331 Plus 100727-100859

405762 5931935 Plus 160502-16111])

405802 5924004 Minus 27743-28264

405804 7274891 Minus 122557-123551

406329 6982072 Minus 607903-608271

406429 9256476 Minus 83206-83365,94051-94193

406502 7711350 Minus 63430 63602

Table 14A lists about 695 genes up-regulated in ovarian cancer compared to nomial adult tissues These were selected from 59680 probesets on the Affymetπx/Eos Hu03 GeneChip array such that the ratio of "average" ovanan cancer to "average" noπnal adult tissues was greater than or equal to 40 The "average" ovarian cancer level was set to the 90th percentile amongst various ovarian cancers The "average" normal adult tissue level was set to the 90th percentile amongst various non-malignant tissues In order to remove gene-specific background levels of non-specific hybπdization, the 15th percentile value amongst vaπous non malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated

TABLE 14A ABOUT 695 UP-REGULATED GENES, OVARIAN CANCER VERSUS NORMAL ADULT TISSUES

Pkey Pπmekey

Ex Accn Exemplar Accession

UG ID UniGene lD

Title UniGene title ratio ratio of tumor vs normal tissues

Pkey Ex Accn UG ID Title ratio

452838 U65011 Hs 30743 Preferentially expressed antigen in melanoma 704

438817 AI023799 Hs 163242 ESTs 628

432938 T27013 Hs 3132 steroidogenic acute regulatory protein 578

421478 AI683243 Hs 97258 ESTs 457

415989 AI267700 Hs 111128 ESTs 427

418179 X51630 Hs 1145 Wilms tumor 1 360

449034 AI624049 gb ts41a09 x1 NCI_CGAP_Ut1 Homo sapiens cDNA clone 340

428579 NM 005756 Hs 184942 G protein-coupled receptor 64 30 5

428153 AW513143 Hs 98367 hypothetical protein FLJ22252 similar to SRY-box c 301

436982 AB018305 Hs 5378 spondin 1, (f-spondin) extracellular matπx protei 294

427585 D31152 Hs 179729 collagen, type X, alpha 1 (Schmid metaphyseal chon 270

435094 AI560129 Hs 277523 EST 262

430691 C14187 Hs 103538 ESTs 262

430491 AL109791 Hs 241559 Homo sapiens mRNA full length insert cDNA clone EU 26 1

415511 AI732617 Hs 182362 ESTs 248

448243 AW369771 Hs 77496 ESTs 247

428187 AI687303 Hs 285529 ESTs 239

408081 AW451597 Hs 167409 ESTs 21 9

418007 M13509 Hs 83169 Matπx metalloprotease 1 (interstitial collagenase 206

400292 AA250737 Hs 72472 BMPR-lb, bone morphogenetic protein receptor; typ 206

422956 BE545072 Hs 122579 ESTs 200

413335 AI613318 Hs 48442 ESTs 19 9

423739 AA398155 Hs 97600 ESTs 189

410929 H47233 Hs 30643 ESTs 185

424086 AI351010 Hs 102267 lysyl oxidase 177

424905 NM 002497 Hs 153704 NIMA (never in mitosis gene a) related kinase 2 174

427356 AW023482 Hs 97849 ESTs 174

407168 R45175 gb yg40f01 s1 Soares infant brain 1 NIB Homo sapien 171

407638 AJ404672 Hs 288693 EST 171

427469 AA403084 Hs 269347 ESTs 170

438993 AA828995 integπn, beta 8 167

428664 AK001666 Hs 189095 similar to SALL1 (sal (Drosophila) like 16 5

439820 AL360204 Hs 283853 Homo sapiens mRNA full length insert cDNA clone EU 165

421155 H87879 Hs 102267 lysyl oxidase 161

426635 BE395109 Hs 129327 ESTs 159

431989 AW972870 Hs 291069 ESTs 159

422805 AA436989 Hs 121017 H2A histone family, member A 159

444783 AK001468 Hs 62180 ESTs 158 424581 M62062 Hs 150917 catenin (cadheπn-associated protein), alpha 2 157

453197 AI916269 Hs 109057 ESTs, Weakly similar to ALU5 HUMAN ALU SUBFAMIL 157

459325 AW088369 Hs 282184 ESTs 156

428976 AL037824 Hs 194695 ras homolog gene family, member I 15 1

416209 AA236776 Hs 79078 MAD2 (mitotic arrest deficient, yeast, homolog) Ii 150

408660 AA525775 Hs 292523 ESTs 150

410247 AF181721 Hs 61345 RU2S 150

418738 AW388633 Hs 6682 solute earner family 7, member 11 150

459583 AI907673 gb IL-BT152-080399 004 BT152 Homo sapiens cDNA, mR 148

413623 AA825721 Hs 246973 ESTs 148

439706 AW872527 Hs 59761 ESTs 147

409041 AB033025 Hs 50081 KIAA1199 protein 146

451110 AI955040 Hs 301584 ESTs 145

436775 AA731111 Hs 291891 ESTs 143

443211 AI128388 Hs 143655 ESTs 143

445258 AI635931 Hs 147613 ESTs 142

447350 AI375572 Hs 172634 ESTs, HER4 (c-erb-B4) 142

428227 AA321649 Hs 2248 INTERFERON-GAMMA INDUCED PROTEIN PRECURS 141

453392 U23752 Hs 32964 SRY (sex determining region Y)-box 11 139

447033 AI357412 Hs 157601 EST - notm UniGene 137

423811 AW299598 Hs 50895 homeo box C4 137

452461 N78223 Hs 108106 transcπptioπ factor 137

451106 BE382701 Hs 25960 N-myc 136

416208 AW291168 Hs 41295 ESTs 135

452249 BE394412 Hs 61252 ESTs 134

452055 AI377431 Hs 293772 ESTs 13 2

439243 AA593254 Hs 191349 ESTs 13 1

420149 AA255920 Hs 88095 ESTs 129

429125 AA446854 Hs 271004 ESTs 129

413597 AW302885 Hs 117183 ESTs 128

416566 NM.003914 Hs 79378 cyclin A1 128

442438 AA995998 gb os26b03 s1 NCI CGAP Kιd5 Homo sapiens cDNA clon 127

407710 AW022727 Hs 23616 ESTs 126

416661 AA634543 Hs 79440 IGF-II mRNA-bindiπg protein 3 126

428392 H10233 Hs 2265 secretory granule, neuroendocπne protein 1 (7B2 p 124

431725 X65724 Hs 2839 Nome disease (pseudoglioma) 123

447700 AI420183 Hs 171077 ESTs, Weakly similar to similar to seπne/threonm 122

458027 L49054 Hs 85195 ESTs, Highly similar to t(3,5)(q25 1 ,p34) fusion g 122

408460 AA054726 Hs 285574 ESTs 122

424735 U31875 Hs 152677 short-chain alcohol dehydrogenase family member 120

415263 AA948033 Hs 130853 ESTs 11 9

400298 AA032279 Hs 61635 STEAP1 11 8

452096 BE394901 Hs 226785 ESTs 11 7

421451 AA291377 Hs 50831 ESTs 11 6

435496 AW840171 Hs 265398 ESTs, Weakly similar to transformation-related pro 11 6

443715 AI583187 Hs 9700 cyclin E1 11 5

402606 #(N0CAT) 11 5

436954 AA740151 Hs 130425 ESTs 11 5

413472 BE242870 Hs 75379 solute camerfamily 1 (glial high affinity gluta 11 5

410102 AW248508 Hs 279727 ESTs, 114

408562 AI436323 Hs 31141 Homo sapiens mRNA for KIAA1568 protein, partial cd 11 4

452030 AL137578 Hs 27607 Homo sapiens mRNA, cDNA DKFZp564N2464 (from clon 11 4

442353 BE379594 Hs 49136 ESTs 11 3

427344 NM 000869 Hs 2142 5-hydroxytryptamιπe (serotonin) receptor 3A 11 2

453160 AI263307 Hs 146228 ESTs 11 2

426427 M86699 Hs 169840 TTK protein kinase 11 1

449433 AI672096 Hs 9012 ESTs 11 1

412723 AA648459 Hs 179912 ESTs 11 1

400250 0 11 1

419752 AA249573 Hs 152618 ESTs 11 1

438167 R28363 Hs 24286 ESTs 11 1

434539 AW748078 Hs 214410 ESTs 109

429918 AW873986 Hs 119383 ESTs 108

450375 AA009647 Hs 8850 a dismtegπn and metalloprotemase domain 12 (mel 108

400289 X07820 Hs 2258 Matπx Metalloprotemase 10 (Stromolys 2) 108

420900 AL045633 Hs 44269 ESTs 108

428758 AA433988 Hs 98502 Homo sapiens cDNA FU14303 fis, clone PLACE2000132 108

446142 AI754693 Hs 145968 ESTs 107

421285 NM.000102 Hs 1363 cytochrome P450, subfamily XVII (steroid 17-alpha- 106

433496 AF064254 Hs 49765 VERY-LONG CHAIN ACYL-COA SYNTHETASE 106

418506 AA084248 Hs 85339 G protein-coupled receptor 39 105

433447 U29195 Hs 3281 neuronal pentraxin II 104

424188 AW954552 Hs 142634 zinc finger protein 104

414245 BE148072 Hs 75850 WAS protein family, member 1 103

426462 U59111 Hs 169993 dermatan sulphate proteoglycan 3 103

418601 AA279490 Hs 86368 calmegm 103

444170 AW613879 Hs 102408 ESTs 103

453616 NM 003462 Hs 33846 dynem, axonemal, light intermediate polypeptide 103

407378 AA299264 gb EST11752 Uterus Homo sapiens cDNA 5' end simila 102

440901 AA909358 Hs 128612 ESTs 102

407366 AF026942 gb Homo sapiens cιg33 mRNA, partial sequence 102

415227 AW821113 Hs 72402 ESTs 102

409269 AA576953 Hs 22972 Homo sapiens cDNA FU13352 fis, clone OVARC1002165 101

450480 X82125 Hs 25040 zinc finger protein 239 101 419088 AI538323 Hs 77496 ESTs 100

453922 AF053306 Hs 36708 budding uninhibited by benzimidazoles 1 (yeast hom 99

428253 AL133640 Hs 183357 Homo sapiens mRNA, cDNA DKFZp586C1021 (from clone 98

426471 M22440 Hs 170009 transforming growth factor, alpha 98

407881 AW072003 Hs 40968 heparan sulfate (glucosamine) 3-0 sulfofransferase 97

452291 AF015592 Hs 28853 CDC7 (cell division cycle 7, S cerevisiae, homolo 97

445537 AJ245671 Hs 12844 EGF-like-domain, multiple 6 97

442875 BE623003 Hs 23625 Homo sapiens clone TCCCTA00142 mRNA sequence 96

423992 AW898292 Hs 137206 Homo sapiens mRNA, cDNA DKFZp564H1663 (from clon 96

412140 AA219691 Hs 73625 RAB6 interacting, kines like (rabkines θ) 96

407721 Y12735 Hs 38018 dual specificity tyrosιne-(Y)-phosphorylatιon regu 96

438209 AL120659 Hs 6111 KIAA0307 gene product 95

429782 NM 005754 Hs 220689 Ras-GTPase activating protein SH3-domaιπ-bιndmg p 95

424945 AI221919 Hs 173438 hypothetical protein FLJ 10582 95

414972 BE263782 Hs 77695 KIAA0008 gene product 94

439262 AA832333 Hs 124399 ESTs 94

403381 #(NOCAT) 0 93

424834 AK001432 Hs 153408 Homo sapiens cDNA FU 10570 fis, clone NT2RP2003117 93

435509 AI458679 Hs 181915 ESTs 93

445413 AA151342 Hs 12677 CG1-147 protein 92

414083 AL121282 Hs 257786 ESTs 92

421373 AA808229 Hs 167771 ESTs 92

430510 AW162916 Hs 241576 hypothetical protein PR02577 91

446999 AA151520 Hs 279525 hypothetical protein PRO2605 91

459587 AA031956 gb zk15e04.§1 Soares .pregnanLuterus.NbHPU Homo sa 91

414569 AF109298 Hs 118258 Prostate cancer associated protein 1 91

406687 M31126 Hs 272620 pregnancy specific beta-1-glycoproteιn 9 90

428479 Y00272 Hs 184572 cell division cycle 2, G1 to S and G2 to M 90

408908 BE296227 Hs 48915 seπne/threonine kinase 15 90

431548 AI834273 Hs 9711 Homo sapiens cDNA FU13018 fis, clone NT2RP3000685 90

433764 AW753676 Hs 39982 ESTs 90

434636 AA083764 Hs 241334 ESTs 89

451807 W52854 Hs 27099 DKFZP564J0863 protein 88

437872 AK002015 Hs 5887 RNA binding motif protein 7 88

443054 AI745185 Hs 8939 yes-associated protein 65 kDa 88

420092 AA814043 Hs 88045 ESTs 88

420159 AI572490 Hs 99785 ESTs 88

447164 AF026941 Hs 17518 Homo sapiens cιg5 mRNA, partial sequence 88

451254 AI571016 Hs 172967 ESTs 88

432677 NM 004482 Hs 278611 UDP-N-acetyl-alpha-D-galactosamine polypeptide N-a 87

450434 AA166950 Hs 18645 ESTs, Weakly similar to partial CDS [C elegans] 87

400301 X03635 Hs 1657 Estrogen receptor 1 87

408829 NM 006042 Hs 48384 heparan sulfate (glucosamine) 3-O-sulfotransferase 87

434891 AA81 309 Hs 123583 ESTs 87

436812 AW298067 gb UI-H-BWO-ajp g 09 0-UI s1 NCI.CGAP.Sub6 Homo s 87

438885 AI886558 Hs 184987 ESTs 87

449765 N92293 Hs 206832 EST, Moderately similar to ALU8 HUMAN ALU SUBFAM 87

447342 AI199268 Hs 19322 ESTs, Weakly similar to "» ALU SUBFAMILY J WARNI 86

434424 AI811202 Hs 125365 Homo sapiens cDNA FLJ23523 fis, clone LNG05548 86

438078 AI016377 Hs 131693 ESTs 86

437212 AI765021 Hs 210775 ESTs 85

417728 AW138437 Hs 24790 KIAA1573 protein 85

438081 H49546 Hs 298964 ESTs 85

411571 AA122393 Hs 70811 hypothetical protein FU20516 84

435663 AI023707 Hs 134273 ESTs 84

424717 H03754 Hs 152213 wingless-type MMTV integration site family, member 84

425734 AF056209 Hs 159396 peptidylglycme alpha-amidatmg moπooxygenase COOH 84

450505 NM 004572 Hs 25051 plakophilm 2 84

436211 AK001581 Hs 80961 polymerase (DNA directed), gamma 83

436396 A1683487 Hs 299112 Homo sapiens cDNA FU11441 fis, clone HEMBA1001323 83

425695 NM.005401 Hs 159238 protein tyrosine phosphatase, non receptor type 14 83

438180 AA808189 Hs 272151 ESTs 82

447268 AI370413 Hs 36563 Homo sapiens cDNA FU22418 fis, clone HRC08590 82

433159 AB035898 Hs 150587 kinesm like protein 2 81

400195 0 81

424906 AI566086 Hs 153716 Homo sapiens mRNA for Hmob33 protein, 3' untransla 81

438202 AW169287 Hs 22588 ESTs 81

438915 AA280174 Hs 23282 ESTs 8 1

448776 BE302464 Hs 30057 transporter similar to yeast MRS2 8 1

453884 AA355925 Hs 36232 KIAA0186 gene product 80

420757 X78592 Hs 99915 androgen receptor (dihydrotestosterone receptor, t 80

439759 AL359055 Hs 67709 Homo sapiens mRNA full length insert cDNA clone EU 80

453102 NM 007197 Hs 31664 frizzled (Drosophila) homolog 10 80

424001 W67883 Hs 137476 KIAA1051 protein 80

434415 BE177494 gb RC6-HT0596-270300-011-C05 HT0596 Homo sapiens c 80

417576 AA339449 Hs 82285 phosphoπbosylglycmamide formyltransferase, phosp 79

438966 AW979074 gb EST391184 MAGE resequences, MAGP Homo sapiens c 79

415245 N59650 Hs 27252 ESTs 79

422352 AA766296 Hs 99200 ESTs 79

425492 AL021918 Hs 158174 zinc finger protein 184 (Kruppel-like) 78

442655 AW027457 Hs 30323 ESTs 78

445657 AW612141 Hs 279575 ESTs 78

450221 AA328102 Hs 24641 cytoskeletoπ associated protein 2 78

426320 W47595 Hs 169300 transforming growth factor, beta 2 78 414142 AW368397 Hs 150042 ESTs 77

412170 D16532 Hs 73729 very low density lipoprotein receptor 76

410011 AB020641 Hs 57856 PFTAIRE protein kinase 1 76

436476 AA326108 Hs 53631 ESTs 76

414132 AI801235 Hs 48480 ESTs 76

437789 AI581344 Hs 127812 ESTs, Weakly similarto AF141326 1 RNA helicase HD 76

450192 AA263143 Hs 24596 RAD51-ιnteractιπg protein 76

449328 AI962493 Hs 197647 ESTs 75

440238 AW451970 Hs 155644 paired box gene 2 75

403657 #{N0CAT) 0 75

408826 AF216077 Hs 48376 Homo sapiens clone HB-2 mRNA sequence 75

418735 N48769 Hs 44609 ESTs 75

413627 BE182082 Hs 246973 ESTs 74

446293 AI420213 Hs 149722 ESTs 74

441627 AA947552 Hs 58086 ESTs 74

425465 L18964 Hs 1904 protein kinase C, iota 73

409242 AL080170 Hs 51692 DKFZP434C091 protein 73

450262 AW409872 Hs 271166 ESTs, Moderately similarto ALU7 HUMAN ALU SUBFA 73

440250 AA876179 Hs 134650 ESTs 73

451659 BE379761 Hs 14248 ESTs, Weakly similar to ALU8.HUMAN ALU SUBFAMIL 73

458861 AI630223 gb ad06g08 r1 Proliferating Erythroid Cells (LCB a 73

436032 AA150797 Hs 109276 latexin protein 72

407771 AL138272 Hs 62713 ESTs 72

435039 AW043921 Hs 130526 ESTs 72

444342 NM.014398 Hs 10887 similar to lysosome-associated membrane glycoprote 72

407829 AA045084 Hs 29725 Homo sapiens cDNA FU13197 fis, clone NT2RP3004451 72

409731 AA125985 Hs 56145 thymosm, beta, identified in πeuroblastoma cells 72

404253 #(N0CAT) 0 71

424120 T80579 Hs 290270 ESTs 71

429126 AW172356 Hs 99083 ESTs 7 1

413573 AI733859 Hs 149089 ESTs 71

421464 AA291553 Hs 190086 ESTs 70

430388 AA356923 Hs 240770 nuclear cap binding protein subunit 2, 20kD 70

437938 AI950087 ESTs, Weakly similar to Gag-Pol polyprotein [M mus 70

420362 U79734 Hs 97206 huntingtm interacting protein 1 70

444743 AA045648 Hs 11817 nudix (nucleoside diphosphate linked moiety X)-typ 70

415138 C18356 Hs 78045 tissue factor pathway inhibitor 2 TFPI2 69

410568 AW162948 Hs 64542 pre-mRNA cleavage factor Im (68kD) 69

429418 AI381028 Hs 99283 ESTs 69

409178 BE393948 Hs 50915 kallikrein 5 69

446608 N75217 Hs 257846 ESTs 69

425905 AB032959 Hs 161700 KIAA1133 protein 69

428532 AF157326 Hs 184786 TBP-mteracting protein 69

433426 H69125 Hs 133525 ESTs 69

431322 AW970622 gb EST382704 MAGE resequences, MAGK Homo sapiens 68

437960 AI669586 Hs 222194 ESTs 68

423244 AL039379 Hs 209602 ESTs, Weakly similar to ubiquitous TPR motif, Y is 68

424085 NM.002914 Hs 139226 replication factor C (activator 1) 2 (40kD) 68

448674 W31178 Hs 154140 ESTs 68

438122 AI620270 Hs 129837 ESTs 68

440048 AA897461 Hs 158469 ESTs, Weakly similar to envelope protein [H sapien 67

418478 U38945 Hs 1174 cyclin-depeπdent kinase inhibitor 2A (melanoma, p1 67

407162 N63855 Hs 142634 zinc finger protein 67

410804 U64820 Hs 66521 Machado-Joseph disease (spinocerebellar ataxia 3, 67

424639 AI917494 Hs 131329 ESTs 67

432415 T16971 Hs 289014 ESTs 67

421470 R27496 Hs 1378 annexm A3 67

445459 AI478629 Hs 158465 ESTs 67

418203 X54942 Hs 83758 CDC28 protein kinase 2 66

432809 AA565509 Hs 131703 ESTs 66

409234 AI879419 Hs 27206 ESTs 66

438394 BE379623 Hs 27693 CGI-124 protein 66

452097 AB002364 Hs 27916 ADAM-TS3 , a dismtegnn like and metalloproteas 66

453745 AA952989 Hs 63908 Homo sapiens HSPC316 mRNA, partial eds 66

414136 AA812434 Hs 178227 ESTs 66

423248 AA380177 Hs 125845 nbulose-5-phosphate-3-epιmerase 66

454018 AW016892 Hs 241652 ESTs 66

452281 T93500 Hs 28792 ESTs 65

424620 AA101043 Hs 151254 kallikrein 7 (chymotryptic, stratum comeum) 65

452594 AU076405 Hs 29981 solute earner family 26 (sulfate transporter), me 65

434149 Z43829 Hs 19574 ESTs, Weakly similar to katanin p80 subunit [H sap 65

425776 U25128 Hs 159499 parathyroid hormone receptor 2 64

418677 S83308 Hs 87224 SRY (sex determining region Y)-box 5 64

409517 X90780 Hs 54668 troponm I, cardiac 64

432666 AW204069 Hs 129250 ESTs, Weakly similar to unnamed protein product [H 64

448706 AW291095 Hs 21814 class II cytokine receptor ZCYTOR7 64

429163 AA884766 gb am20a10 s1 Soares_NFL_T_GBC_S1 Homo sapiens cDN 64

413582 AW295647 Hs 71331 Homo sapiens cDNA FU21971 fis, clone HEP05790 64

419917 AA320068 Hs 93701 Homo sapiens mRNA, cDNA DKFZp434E232 (from clone 64

424153 AA451737 Hs 141496 MAGE-hke 2 64

434265 AA846811 Hs 130554 Homo sapiens cDNA FU23089 fis, clone LNG07061 64

435082 AA664273 Hs 186104 Homo sapiens cDNA FU13803 fis, clone THYRO1000187 64

441081 AI584019 Hs 169006 ESTs, Moderately similar to plakophil 2b [H sapi 64

443539 AI076182 Hs 134074 ESTs 64 443830 AI142095 Hs 143273 ESTs 64

452606 N45202 Hs 90012 Homo sapiens cDNA FU23441 fis, clone HSI00612 64

418384 AW149266 Hs 25130 ESTs 63

425371 D49441 Hs 155981 mesothelin 63

429441 AJ224172 Hs 204096 lipophilm B (uteroglobin family member), prostate 63

449048 Z45051 Hs 22920 similar to S68401 (cattle) glucose induced gene 63

437117 AL049256 Hs 122593 ESTs 63

449579 AW207260 Hs 134014 prostate cancer associated protein 6 63

453370 AI470523 Hs 182356 ESTs, Moderately similar to translation initiation 63

426514 BE616633 Hs 301122 bone morphogenetic protein 7 (osteogenic protein 1 "63

415076 NM 000857 Hs 77890 guanylate cyclase 1, soluble, beta 3 63

408155 AB014528 Hs 43133 KIAA0628 gene product 62

452904 AL157581 Hs 30957 Homo sapiens mRNA, cDNA DKFZp434E0626 (from clone 62

439138 AI742605 Hs 193696 ESTs 62

457030 AI301740 Hs 173381 dihydropyπmidmase-like 2 62

436281 AW411194 Hs 120051 ESTs 61

407385 AA610150 Hs 272072 ESTs, Moderately similar to ALU7.HUMAN ALU SUBFA 6 1

406815 AA833930 Hs 288036 tRNA isopentenylpyrophosphate traπsferase 6 1

430437 AI768801 Hs 169943 Homo sapiens cDNA FU13569 fis, clone PLACE1008369 6 1

428743 AL080060 Hs 301549 Homo sapiens mRNA, cDNA DKFZp564H172 (from clone 6 1

415139 AW975942 Hs 48524 ESTs 6 1

417404 NM 007350 Hs B2101 pleckstnn homology-like domain, family A, member 61

433527 AW235613 Hs 133020 ESTs 61

449448 D60730 Hs 57471 ESTs 61

457733 AW974812 Hs 291971 ESTs 61

457979 AA776655 Hs 270942 ESTs 61

422867 L32137 Hs 1584 cartilage oligomeric matrix protein 60

423554 M90516 Hs 1674 glutamιne-fructose-6-phosphate transa mase 1 60

421502 AF111856 Hs 105039 solute earner family 34 (sodium phosphate), membe 60

412733 AA984472 Hs 74554 KIAA0080 protein 60

422095 AI868872 Hs 288966 ceruloplasmin (ferroxidase) 60

449347 AV649748 Hs 295901 ESTs 60

440870 AI687284 Hs 150539 Homo sapiens cDNA FLJ13793 fis, clone THYRO1000085 60

437478 AL390172 Hs 118811 ESTs 60

411598 BE336654 Hs 70937 H3 histone family, member K 60

418134 AA397769 Hs 86617 ESTs 60

418845 AA852985 Hs 89232 chromobox homolog 5 (Drosophila HP1 alpha) 60

452039 AI922988 Hs 172510 ESTs 60

410555 U92649 Hs 64311 a disintegπn and metalloproteinase domain 17 (turn 59

412719 AW016610 Hs 129911 ESTs 59

410566 AA373210 Hs 43047 Homo sapiens cDNA FU13585 fis, clone PLACE1009150 59

437099 N77793 Hs 48659 ESTs, Highly similar to LMA1.HUMAN LAMININ ALPH 59

453431 AF094754 Hs 32973 glycine receptor, beta 59

408920 AL120071 Hs 48998 fibronectin leucine nch transmembrane protein 2 59

417866 AW067903 Hs 82772 "collagen, type XI, alpha 1" 59

420440 NM.002407 Hs 97644 mammaglobm 2 59

430291 AV660345 Hs 238126 CGI-49 protein 59

405547 #(NOCAT) 0 59

427510 Z47542 Hs 179312 small nuclear RNA activating complex, polypeptide 59

435793 AB037734 Hs 4993 ESTs 58

427975 AI536065 Hs 122460 ESTs 58

428949 AA442153 Hs 104744 ESTs, Weakly similar to AF208855 1 BM 013 [H sapie 58

452693 T79153 Hs 48589 zinc finger protein 228 58

440138 AB033023 Hs 6982 hypothetical protein FLJ10201 58

421246 AW582962 Hs 300961 ESTs, Highly similar to AF151805 1 CGI47 protein 58

445424 AB028945 Hs 12696 cortactin SH3 domain-binding protein 58

448186 AA262105 Hs 4094 Homo sapiens cDNA FLJ14208 fis, clone NT2RP3003264 58

425154 NM 001851 Hs 154850 collagen, type IX, alpha 1 57

419335 AW960146 Hs 284137 Homo sapiens cDNA FU12888 fis, clone NT2RP2004081 57

420637 AW976 53 gb EST388262 MAGE resequences, MAGN Homo sapiens 57

431924 AK000850 Hs 272203 Homo sapiens cDNA FU20843 fis, clone ADKA01954 57

446868 AV660737 Hs 135100 ESTs 57

452971 AI873878 Hs 91789 ESTs 57

428927 AA441837 Hs 90250 ESTs 57

425282 AW163518 Hs 155485 huntingtm interacting protein 2 57

419247 S65791 Hs 89764 fragile X mental retardation 1 57

445640 AW969626 Hs 31704 ESTs, Weakly similar to KIAA0227 [H sapiens] 57

422938 NM 001809 Hs 1594 centromere protein A (17kD) 56

447078 AW885727 Hs 301570 ESTs 56

421247 BE391727 Hs 102910 general transcription factor IIH, polypeptide 4 (5 56

407896 D76435 Hs 41154 Zic family member 1 (odd-paired Drosophila homolog 56

436556 AI364997 Hs 7572 ESTs 56

417830 AW504786 Hs 132808 epithelial cell transforming sequence 2 oncogene 56

429826 N93266 Hs 40747 ESTs 56

432030 AI908400 Hs 143789 ESTs 56

443270 NM 004272 Hs 9192 Homer, neuronal immediate early gene, 1B 55

453900 AW003582 Hs 226414 ESTs, Weakly similar to ALU8.HUMAN ALU SUBFAMIL 55

411096 U80034 Hs 68583 mitochondπal intermediate peptidase 55

419558 AW953679 Hs 278394 ESTs 55

427386 AW836261 Hs 177486 amyloid beta (A4) precursor protein (protease nexi 55

427961 AW293165 Hs 143134 ESTs 55

404561 #(NOCAT) 0 55

429682 NM 006306 Hs 211602 SMC1 (structural maintenance of chromosomes 1, yea 55

407216 N91773 Hs 102267 lysyl oxidase 55 410658 AW105231 Hs 192035 ESTs 55

413830 M86153 Hs 75618 RAB11 A, member RAS oncogene family 55

414315 Z24878 gb HSB65D052 STRATAGENE Human skeletal muscle cD 55

427878 C05766 Hs 181022 CGI-07 protein 55

431041 AA490967 Hs 105276 ESTs 55

441645 A1222279 Hs 201555 ESTs 55

428071 AF212848 Hs 182339 transcπption factor ESE-3B 54

436406 AW105723 Hs 125346 ESTs 54

429181 AW979104 Hs 294009 ESTs 54

410909 AW898161 Hs 53112 ESTs, Weakly similar to ALU8.HUMAN ALU SUBFAMIL 54

424345 AK001380 Hs 145479 Homo sapiens cDNA FU10518 fis clone NT2RP2000814 54

451996 AW514021 Hs 245510 ESTs 54

449318 AW236021 Hs 108788 ESTs Weakly similarto zeste [D melanogaster] 54

441433 AA933809 Hs 42746 ESTs 54

445495 BE622641 Hs 38489 ESTs 54

410153 BE311926 Hs 15830 Homo sapiens cDNA FU12691 fis, clone NT2RM4002571 54

442611 BE077155 Hs 177537 ESTs 54

452401 NM_007115 Hs 29352 tumor necrosis factor, alpha induced protein 6 54

453161 AA628608 Hs 61656 ESTs 54

419948 AB041035 Hs 93847 NADPH oxidase 4 53

427718 AI798680 Hs 25933 ESTs 53

453867 AI929383 Hs 108196 HSPC037 protein 53

422634 NM 016010 Hs 118821 CGI-62 protein 53

444478 W07318 Hs 240 M phase phosphoprotein 1 53

428002 AA418703 gb zv98c03 §1 Soares.NhHMPu.S1 Homo sapiens cDNA c 53

443486 NM.003428 Hs 9450 zinc finger protein 84 (HPF2) 53

451177 AI969716 Hs 13034 ESTs 53

408298 AI745325 Hs 271923 ESTs, Moderately similar to mi ALU SUBFAMILY SB2 53

435867 AA954229 Hs 114052 ESTs 53

423698 AA329796 Hs 1098 DKFZp434J1813 protein 53

448543 AW897741 Hs 21380 Homo sapiens mRNA, cDNA DKFZp586P1124 (from clone 53

427660 AI741320 Hs 114121 Homo sapiens cDNA FU23228 fis clone CAE06654 53

430345 AK000282 Hs 239681 hypothetical protein FU20275 53

433222 AW514472 Hs 238415 ESTs, Moderately similar to ALU8 HUMAN ALU SUBFA 53

449532 W74653 Hs 271593 ESTs 53

452822 X85689 Hs 288617 Homo sapiens cDNA FLJ22621 fis, clone HSI05658 53

437641 AA811452 Hs 291911 ESTs 52

418379 AA218940 Hs 137516 fidgetin like 1 52

416530 U62801 Hs 79361 kallikrein 6 (neurosm, zyme) 52

433589 AA886530 Hs 188912 ESTs 52

409143 AW025980 Hs 138965 ESTs 52

410303 AA324597 Hs 21851 Homo sapiens cDNA FLJ12900 fis clone NT2RP2004321 52

413384 NM.000401 Hs 75334 exostoses (multiple) 2 52

424698 AA164366 Hs 151973 hypothetical protein FU10378 52

431229 AA496479 gb zv37h05 r1 Soares ovary tumor NbHOT Homo sapien 52

433377 AI752713 Hs 43845 ESTs 52

445236 AK001676 Hs 12457 hypothetical protein FLJ 10814 52

406367 #(NOCAT) 0 52

442500 AI819068 Hs 209122 ESTs 52

450101 AV649989 Hs 24385 Human hbc647 mRNA sequence 52

419140 A1982647 Hs 215725 ESTs 52

411078 AI222020 Hs 182364 ESTs, Weakly similar to 25 kDa trypsin inhibitor [ 52

423020 AA383092 Hs 1608 replication protein A3 (14kD) 52

427061 AB032971 Hs 173392 KIAA1145 protein 52

439042 AW979172 gb EST391282 MAGE resequences, MAGP Homo sapiens c 52

452930 AW195285 Hs 194097 ESTs 52

417791 AW965339 Hs 111471 ESTs 51

433277 W27266 Hs 151010 ESTs 5 1

447835 AW591623 Hs 164129 ESTs 51

434401 AI864131 Hs 71119 Putative prostate cancer tumor suppressor 51

437496 AA452378 Hs 170144 Homo sapiens mRNA, cDNA DKFZp547J125 (from clone D 51

418849 AW474547 Hs 53565 ESTs, Weakly similar to B0491 1 [C elegans] 5 1

428093 AW594506 Hs 104830 ESTs 5 1

408621 AI970672 Hs 46638 chromosome 11 open reading frame 8, fetal brain ( 51

453096 AW294631 Hs 11325 ESTs 51

418852 BE537037 Hs 273294 hypothetical protein FU20069 51

436787 AA908554 Hs 192756 ESTs 5 1

446577 AB040933 Hs 15420 KIAA1500 protein 51

437267 AW511443 Hs 258110 ESTs 50

419423 D26488 Hs 90315 KIAA0007 protein 50

404939 0 50

439052 AF085917 Hs 37921 ESTs 50

447020 T27308 Hs 16986 hypothetical protein FU11046 50

453878 AW964440 Hs 19025 ESTs 50

410824 AW994813 Hs 33264 ESTs 50

427701 AA411101 Hs 221750 ESTs 50

424602 AK002055 Hs 301129 Homo sapiens clone 23859 mRNA sequence 50

430044 AA464510 Hs 152812 EST cluster (not in UniGene) 50

417423 AA197341 Hs 111164 ESTs 50

421477 AI904743 Hs 104650 hypothetical protein FLJ 10292 50

433384 AI021992 Hs 124244 ESTs 50

434160 BE551196 Hs 114275 ESTs 50

443555 N71710 Hs 21398 ESTs, Moderately similar to GNPI HUMAN GLUCOSAM 50

416198 H27332 Hs 99598 ESTs 49 424539 L02911 Hs 150402 activin A receptor, type I 49

436645 AW023424 Hs 156520 ESTs 49

417251 AW015242 Hs 99488 ESTs, Weakly similar to ORF YKR074w [S cerevisiae] 49

447207 AA442233 Hs 17731 hypothetical protein FLJ 12892 49

416565 AW000960 Hs 44970 ESTs 49

425292 NM 005824 Hs 155545 37 kDa leucme-πch repeat (LRR) protein 49

435420 AI928513 Hs 59203 ESTs 49

435532 AW291488 Hs 117305 ESTs 49

443268 AI800271 Hs 129445 hypothetical protein FU 12496 49

446140 AA356170 Hs 26750 Homo sapiens cDNA FU21908 fis, clone HEP03830 49

452891 N75582 Hs 212875 ESTs, Weakly similar to KIAA0357 [H sapiens] 49

431130 NM.006103 Hs 2719 epididymis-specific, whey-acidic protein type, fou 49

408938 AA059013 Hs 22607 ESTs 49

432842 AW674093 Hs 279525 hypothetical protein PRO2605 49

436754 AI061288 Hs 133437 ESTs, Moderately similar to gonadotropin inducible 49

442573 H93366 Hs 7567 Branched chain aminofransferase 1, cytosolic, U215 49

409049 AI423132 Hs 146343 ESTs 49

422475 AL359938 Hs 117313 Meis (mouse) homolog 3 49

447112 H17800 Hs 7154 ESTs 49

458627 AW088642 Hs 97984 ESTs, Weakly similar to WASP-fa ily protein [H sap 48

431689 AA305688 Hs 267695 UDP-Gal betaGlcNAc beta 1,3-galactosylfransferase, 48

410530 M25809 Hs 64173 ESTs, Highly similar to VAB1JHUMAN VACUOLAR AT 48

429414 AI783656 Hs 202095 empty spiracles (Drosophila) homolog 2 48

418882 NM 004996 Hs 89433 ATP-binding cassette, sub-family C (CFTR/MRP), mem 48

422505 AL120862 Hs 124165 ESTs, (HSAJPAP protein (programmed cell death 9, 48

425977 R15138 Hs 165570 Homo sapiens clone 25052 mRNA sequence 48

428555 NM 002214 Hs 184908 integπn, beta 8 48

452909 NM 015368 Hs 30985 pannexm 1 48

449535 W15267 Hs 23672 low density lipoprotein receptor-related protein 6 48

452232 AW020603 Hs 271698 ESTs 48

409732 NM 016122 Hs 56148 NY-REN-58 antigen 48

415115 AA214228 Hs 127751 hypothetical protein 47

423161 AL049227 Hs 124776 Homo sapiens mRNA, cDNA DKFZp564N1116 (from clon 47

441085 AW136551 Hs 181245 Homo sapiens cDNA FLJ12532 fis, clone NT2RM4000200 47

423575 C18863 Hs 163443 ESTs 47

415211 R64730 comp Hs 155986 ESTs, Highly similar to SPERM SURFACE PROTEIN SP1 47

418804 AA809632 gb nz17h04 s1 NCI.CGAP.GCB1 Homo sapiens cDNA clo 47

428405 Y00762 Hs 2266 cholinergic receptor, nicotinic, alpha polypeptide 47

432865 AI753709 Hs 152484 ESTs 47

433330 AW207084 Hs 132816 ESTs 47

453047 AW023798 Hs 286025 ESTs 47

421308 AA687322 Hs 192843 ESTs 47

456273 AF154846 Hs 1148 zinc finger protein 47

443933 AI091631 Hs 135501 Homo sapiens two pore potassium channel KT33 47

434551 BE387162 Hs 280858 ESTs, Highly similar to XPB.HUMAN DNA-REPAIR PRO 47

440351 AF030933 Hs 7179 RAD1 (S pombe) homolog 47

426300 U15979 Hs 169228 delta-like homolog (Drosophila) 47

453775 NM 002916 Hs 35120 replication factor C (activator 1) 4 (37kD) 47

446102 AW168067 Hs 252956 ESTs 47

420547 AF155140 Hs 98738 goπadotropin-regulated testicular RNA helicase 47

429486 AF155827 Hs 203963 hypothetical protein FU10339 47

429944 R13949 Hs 226440 Homo sapiens clone 24881 mRNA sequence 47

433042 AW193534 Hs 281895 Homo sapiens cDNA FU11660 fis, clone HEMBA1004610 47

434988 AI418055 Hs 161160 ESTs 46

452571 W31518 Hs 34665 ESTs 46

434361 AF129755 Hs 117772 ESTs 46

406400 #(NOCAT) 0 46

410227 AB009284 Hs 61152 exostoses (multiple) like 2 46

419945 AW290975 Hs 118923 ESTs 46

428301 AW628666 Hs 98440 ESTs 46

430153 AW968128 gb EST380338 MAGE resequences, MAGJ Homo sapiens c 46

431349 AA503653 Hs 156942 ESTs, Moderately similar to ALU2 HUMAN ALU SUBFA 46

446254 BE179829 Hs 179852 Homo sapiens cDNA FU12832 fis, clone NT2RP2003137 46

447505 AL049266 Hs 18724 Homo sapiens mRNA, cDNA DKFZp564F093 (from clone 46

448027 AI458437 Hs 177224 ESTs 46

449611 AI970394 Hs 197075 ESTs 46

459574 AI741122 Hs 101810 Homo sapiens cDNA FU14232 fis, clone NT2RP4000035 46

409928 AL137163 Hs 57549 hypothetical protein dJ473B4 46

409387 AW384900 Hs 123526 ESTs 46

424078 AB006625 Hs 139033 paternally expressed gene 3 46

435244 N77221 Hs 187824 ESTs 46

404996 #(NOCAT) 0 46

407905 AW103655 Hs 252905 ESTs 46

411560 AW851186 gb IL3-CT0220-150200-071-H05 CT0220 Homo sapiens c 46

424341 AA385074 gb EST98673 Thyroid Homo sapiens cDNA 5' end simil 46

441675 AI914329 Hs 5461 ESTs 46

452172 H00797 Hs 133207 Homo sapiens mRNA for KIAA1230 protein, partial cd 46

420276 AA290938 Hs 190561 ESTs, Highly similar to mosaic protein LR11 [H sap 45

402820 #(NOCAT) 0 45

419699 AA248998 Hs 31246 ESTs 45

422529 AW015128 Hs 256703 ESTs 45

438018 AK001160 Hs 5999 hypothetical protein FU 10298 45

441826 AW503603 Hs 129915 phosphotπesterase related 45

453931 AL121278 Hs 25144 ESTs 45 435538 AB011540 Hs.4930 low density lipoprotein receptor-related protein 4 4.5

457465 AW301344 Hs.195969 ESTs 4.5

418848 AI820961 Hs.193465 ESTs 4.5

408321 AW405882 Hs.44205 cortistalin 4.5

447499 AW262580 Hs.147674 KIAA1621 protein 4.5

424513 BE385864 Hs.149894 mitochondrial translational initiation factor 2 4.5

432731 R31178 Hs.287820 fibronectin 1 4.5

448275 BE514434 Hs.20830 syπaptic Ras GTPase activating protein 1 (homolog 4.5

430371 D87466 Hs.240112 KIAA0276 protein 4.5

448693 AW004854 Hs.228320 Homo sapiens cDNA: FU23537 fis, clone LNG07690 4.5

407289 AA135159 Hs.203349 Homo sapiens cDNA FU12149 fis, clone MAMMA100042 4.4

448141 AI471598 Hs.197531 ESTs 4.4

434699 AA643687 Hs.149425 Homo sapiens cDNA FU11980 fis, clone HEMBB1001304 4.4

417718 T86540 Hs.193981 ESTs 4.4

436464 AI016176 Hs.269783 ESTs, Weakly similar to ALU1.HUMAN ALU SUBFAMIL 4.4

427528 AU077143 Hs.179565 minichromosome maintenance deficient (S. cerevisia 4.4

409092 AI735283 Hs.172608 ESTs 4.4

416241 N52639 Hs.32683 ESTs 4.4

432005 AA524190 Hs.120777 ESTs, Weakly similar to ELL2 HUMAN RNA POLYMER 4.4

440234 AW117264 Hs.126252 ESTs 4.4

448743 AB032962 Hs.21896 KIAA1136 protein 4.4

451389 N73222 Hs.21738 KIAA1008 protein 4.4

453331 AI240665 Hs.8895 ESTs 4.4

454036 AA374756 Hs.93560 ESTs, Weakly similar to unnamed protein product [H 4.4

448133 AA723157 Hs.73769 folate receptor 1 (adult) 4.4

429597 NM 003816 Hs.2442 a dislntegrin and metalloproteinase domain 9 (melt 4.4

453279 AW893940 Hs.59698 ESTs 4.4

409459 D86407 Hs.54481 low density lipoprotein receptor-related protein 8 4.4

431708 AI698136 Hs.108873 ESTs 4.4

433906 AI167816 Hs.43355 ESTs 4.4

437958 BE139550 Hs.121668 ESTs 4.4

441423 AI793299 Hs.126877 ESTs 4.4

429876 AB028977 Hs.225974 KIAA1054 protein 4.3

446770 AV660309 Hs.154986 ESTs, Weakly similar to AF137386 1 plasmolipiπ [H. 4.3

412078 X69699 Hs.73149 paired box gene 8 4.3

422093 AF151852 Hs.111449 CGI-94 protein 4.3

423123 NM 012247 Hs.124027 SELENOPHOSPHATE SYNTHETASE ; Human selenium 4.3

448390 AL035414 Hs.21068 hypothetical protein 4.3

453628 AW243307 Hs.170187 ESTs 4.3

449722 BE280074 Hs.23960 cyclin B1 4.3

436679 AI127483 Hs.120451 ESTs, Weakly similar to unnamed protein product [H 4.3

431592 R69016 Hs.293871 ESTs, Weakly similar to ALU1.HUMAN ALU SUBFAMIL 4.3

432383 AK000144 Hs.274449 Homo sapiens cDNA FU20137 fis, clone COL07137 4.3

419926 AW900992 Hs.93796 DKFZP586D2223 protein 4.3

452367 U71207 Hs.29279 eyes absent (Drosophila) homolog 2 4.3

401644 #(NOCAT) 0 4.3

410044 BE566742 Hs.58169 highly expressed in cancer, rich in leucine heptad 4.3

413775 AW409934 Hs.75528 nucleolar GTPase 4.3

424296 AI631874 Hs.169391 ESTs 4.3

431118 BE264901 Hs.250502 carbonic anhydrase VIII 4.3

432201 AI538613 Hs.135657 TMPRSS3a mRNA for serine protease (ECHOS1) (TADG-1 4.3

451073 AI758905 Hs.206063 ESTs 4.3

451592 AI805416 Hs.213897 ESTs 4.3

452453 AI902519 gb:QV-BT009-101198-051 BT009 Homo sapiens cDNA, m 4.3

441020 W79283 Hs.35962 ESTs 4.2

439024 R96696 Hs.35598 ESTs 4.2

453619 H87648 Hs.33922 H.sapiens novel gene from PAC 117P20, chromosome 1 4.2

453469 BE047032 Hs.257789 ESTs 4.2

408427 AW194270 Hs.177236 ESTs 4.2

419311 AA689591 gb:nv66a12.s1 NCI_CGAP_GCB1 Homo sapiens cDNA clo 4.2

426460 D79721 Hs.183702 Homo sapiens cDNA FU11752 fis, clone HEMBA1005582 4.2

444540 AI693927 Hs.265165 ESTs 4.2

452943 BE247449 Hs.31082 hypothetical protein FU 10525 4.2

453913 AW004683 Hs.233502 ESTs 4.2

417847 AI521558 Hs.288312 Homo sapiens cDNA: FU22316 fis, clone HRC05262 4.2

428856 AA436735 Hs.183171 Homo sapiens cDNA: FU22002 fis, clone HEP06638 4.2

428679 AA431765 gb:zw80c03.s1 Soares.testis.NHT Homo sapiens cDNA 4.2

441006 AW605267 Hs.7627 CGI-60 protein 4.2

436209 AW850417 Hs.254020 ESTs, Moderately similar to unnamed protein produc 4.2

446936 H10207 Hs.47314 ESTs 4.2

406076 AL390179 Hs.137011 Homo sapiens mRNA; cDNA DKFZp547P134 (from clone 4.2

428819 AL135623 Hs.193914 KIAA0575 gene product 4.2

406671 AA129547 Hs.285754 met proto-oncogene (hepatocyte growth factor recep 4.2

418432 M14156 Hs.85112 insulin-like growth factor 1 (somatomedia C) 4.2

417048 AI088775 Hs.55498 geranylgeraπyl diphosphate synthase 1 4.2

431750 AA514986 Hs.283705 ESTs 4.2

439314 AA382413 Hs.178144 ESTs 4.2

448582 AI538880 Hs.94812 ESTs 4.2

449554 AA682382 Hs.59982 ESTs 4.2

455700 BE068115 gb:CM1-BT0368-061299-060-g07 BT0368 Homo sapiens c 4.2

409073 AA063458 gb:zf71a07.s1 Soares _pineal_gland_N3HPG Homo sapie 4.1

433929 AI375499 Hs.27379 ESTs 4.1

415457 AW081710 Hs.7369 ESTs, Weakly similar to ALU1.HUMAN ALU SUBFAMIL 4.1

444381 BE387335 Hs.283713 ESTs 4.1 451024 AA442176 gb zw63b08 r1 Soares_total_fetus_Nb2HF8_9w Homo sa 41

415539 AI733881 Hs 72472 BMPR-lb, bone morphogenetic protein receptor; typ 41

421515 Y11339 Hs 105352 GalNAc alpha-2, 6-sιalyltransferase I, long form 41

420736 AI263022 Hs 82204 ESTs 41

453293 AA382267 Hs 10653 ESTs 41

409564 AA045857 Hs 54943 fracture callus 1 (rat) homolog 41

418378 AW962081 gb EST374154 MAGE resequences, MAGG Homo sapiens 41

429628 H09604 Hs 13268 ESTs 41

439635 AA477288 Hs 94891 Homo sapiens cDNA FU22729 fis, clone HSI15685 41

440452 AI925136 Hs 55150 ESTs, Weakly similar to CAYP.HUMAN CALCYPH0S1N 41

443695 AW204099 Hs 112759 ESTs, Weakly similar to AF126780 1 retinal short-c 41

448816 AB033052 Hs 22151 KIAA1226 protein 41

452795 AW392555 Hs 18878 hypothetical protein FU21620 41

443171 BE281128 Hs 9030 TONDU 41

425322 U63630 Hs 155637 protein kinase, DNA-activated, catalytic polypepti 41

442717 R88362 Hs 180591 ESTs, Weakly similar to R06F65b [C elegans] 41

414747 U30872 Hs 77204 centromere protein F (350/400kD, mitosin) 41

417300 AI765227 Hs 55610 solute camerfamily 30 (zinc transporter), membe 41

417389 BE260964 Hs 82045 Midkme (neuπte growth-promoting factor 2) 4 1

448105 AW591433 Hs 170675 ESTs, Weakly similar to TMS2 HUMAN TRANSMEMBR 41

419131 AA406293 Hs 301622 ESTs 4 1

406348 #(N0CAT) 0 41

419750 AL079741 Hs 183114 Homo sapiens cDNA FU14236 fis, clone NT2RP4000515 41

419790 U79250 Hs 93201 glycerol-3-phosphate dehydrogenase 2 (mitochoπdπa 4 1

420908 AL049974 Hs 100261 Homo sapierjs mRNA, cDNA DKFZp564B222 (from clone 41

421039 NM 003478 Hs 101299 cullm 5 41

426890 AA393167 Hs 41294 ESTs 41

428571 NM.006531 Hs 2291 Probe hTg737 (polycystic kidney disease, autosomal 41

452834 A1638627 Hs 105685 ESTs 41

428771 AB028992 Hs 193143 KIAA1069 protein 40

437949 U78519 Hs 41654 ESTs 40

450568 AL050078 Hs 25159 Homo sapiens cDNA FLJ 10784 fis, clone NT2RP4000448 40

424081 NM 006413 Hs 139120 πbonuclease P (30kD) 40

418375 NM 003081 Hs 84389 synaptosomal associated protein, 25kD 40

447204 AI366881 Hs 157897 ESTs, Moderately similar to ALUC.HUMAN "" ALU CL 40

407910 AA65Q274 Hs 41296 fibronectin leucine πch transmembrane protein 3 40

412314 AA825247 Hs 250899 heat shock factor binding protein 1 40

436291 BE568452 Hs 5101 ESTs, Highly similar to protein regulating cytokin 40

450654 AJ245587 Hs 25275 Kruppel-type zinc finger protein 40

426991 AK001536 Hs 285803 Homo sapiens cDNA FLJ12852 fis, clone NT2RP2003445 40

409365 AA702376 Hs 226440 Homo sapiens clone 24881 mRNA sequence 40

410784 AW803201 gb IL2-UM0077-070500-080-E06 UM0077 Homo sapiens c 40

413374 NM 001034 Hs 75319 πbonucleotide reductase M2 polypeptide 40

413425 F20956 gb HSPD05390 HM3 Homo sapiens cDN A clone 032-X4-1 40

417655 AA780791 Hs 14014 ESTs, Weakly similar to KIAA0973 protein [H sapien 40

424783 AA913909 Hs 153088 TATA box binding protein (TBP)-assocιated factor, 40

425024 R39235 Hs 12407 ESTs 40

445941 A1267371 Hs 172636 ESTs 40

448595 AB014544 Hs 21572 KIAA0644 gene product 40

453448 AL036710 Hs 209527 ESTs 40

458944 N93227 Hs 98403 ESTs 40

400284 Estrogen receptor 1 40

441134 W29092 Hs 7678 cellular retmoic acid binding protein 1 40

408796 AA688292 Hs 118553 ESTs 40

408296 AL117452 Hs 44155 DKFZP586G1517 protein 40

438913 AI380429 Hs 172445 ESTs 40

402408 0 40

411630 U42349 Hs 71119 Putative prostate cancer tumor suppressor 40

450701 H39960 Hs 288467 Homo sapiens cDNA FU12280 fis, clone MAMMA100174 40

439780 AL109688 gb Homo sapiens mRNA full length insert cDNA clone 40

418301 AW976201 Hs 187618 ESTs 40

420077 AW512260 Hs 87767 ESTs 40

426572 AB037783 Hs 170623 hypothetical protein FU11183 40

403721 0 40

411945 AL033527 Hs 92137 v-myc avian myelocytomatosis viral oncogene homolo 40

408684 R61377 Hs 12727 hypothetical protein FU21610 40

414869 AA157291 Hs 72163 ESTs 40

437980 R50393 Hs 278436 KIAA1474 protein 40

451050 AW937420 Hs 69662 ESTs 40

TABLE 14B

Pkey Unique Eos probeset identifier number CAT number Gene cluster number Accession Genbank accession numbers

Pkey CAT Numtx Accession

409073 109851 1 AA063458 AA063018 AI444822

410784 1221005.1 AW803201 BE079700 BE062940

411560 1249443 1 AW851186 AW996967 BE143456

413425 136885 1 F20956 AA129374 AA133740 AW819878

414315 143512 1 Z24878 AA494098 F13654 AA494040 AA143127

418378 174656 1 AW962081 AA218925 AA354237

418804 179138 1 AA809632 AI917245 AI701732 AA228406

419311 183793 1 AA689591 AW974261 AA236240 AI077451 AA631399 AW974262 420637 195241 1 AW976153 AA278945 AA747691

424341 238294 1 AA385074 AA339054 AA339115 AW956359

428002 285602J AA418703 AA418711 BE071915 BE071920 BE071912

428679 294049 1 AA431765 AA432015

429163 300543 1 AA884766 AW974271 AA592975 AA447312

430153 313709 1 AW968128 AA468102 AA468165

431229 330060 1 AA496479 T89859 AW020056 AW135251 AI221100 AA628705 AI263148 T79074

431322 331543 1 AW970622 AA503009 AA502998 AA502989 AA502805 T92188

434415 385931 1 BE177494 AW276909 AA632849

443366881122 442277332233.11 AW298067 AA731645 AA810101 AW194180 AI690673 AW978773

437938 44573 2 AI950087 N70208 R97040 N36809 AI308119 AW967677 N35320 AI251473 H59397 AW971573 R97278 W01059 AW967671 AA908598

AA251875 AI820501 AI820532 W87891 T85904 U71456 T82391 BE328571 T75102 R34725 AA884922 BE328517 AI219788 AA884444 N92578

F13493 AA927794 AI560251 AW874068 AL134043 AW235363 AA663345 AW008282 AA488964 AA283144 AI890387 AI950344 AI741346

AI689062 AA282915 AW102898 AI872193 AI763273 AW173586 AW150329 AI653832 AI762688 AA988777 AA488892 AI356394 AW103813

AI539642 AA642789 AA856975 AW505512 AI961530 AW629970 BE612881 AW276997 AW513601 AW512843 AA044209 AW856538

AA180009 AA337499 AW961101 AA251669 AA251874 AI819225 AW205862 A1683338 AI858509 AW276905 AI633006 AA972584 AA908741

AW072629 AW513996 AA293273 AA969759 N75628 N22388 H84729 H60052 T92487 A1022058 AA780419 AA551005 W80701 AW613456

AI373032 AI564269 F00531 H83488 W37181 W78802 R66056 AI002839 R67840 AA300207 AW959581 T63226 F04005

4 43388996666 4 4667744336611 AW979074AA834841 AA828650 4 43388999933 4 46677665511.11 AA828995 AA834879 AI926361

439042 468079 1 AW979172 AA829595 R96050

439780 47673 1 AL109688 R23665 R26578

442438 542469 1 AA995998 AI916584 R61781 T77332 F07756 F08149 F07647

449034 794817.1 AI624049 AW117770AI858360 4 45511002244 8 855556655 J 1 AA442176 AA259181

452453 918300 1 AI902519AI902518AI90'2516

455700 1351264 1 BE068115 BE068104 BE068102 BE068096 BE068103 BE068154 BE068198

458861 798085 1 AI630223 AI630470 TABLE 14C

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham I et al " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489495

Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons

Pkey Ref Strand NLposition

401644 8576138 Plus 82655-83959

402408 9796239 Minus 110326-110491

402606 9909429 Minus 81747-82094

402820 6456853 Minus 82274-82443

403381 9438267 Minus 26009-26178

403657 8843996 Minus 156223 156370

403721 7528046 Minus 156647-157366

404253 9367202 Minus 55675-56055

404561 9795980 Minus 69039-70100

404939 6862697 Plus 175318-175476

404996 6007890 Plus 37999-38145,38652-38998,39727-39872,4055740674,4235142450

405547 1054740 Plus 124361-124520,124914-125050

406348 9255985 Minus 71754-71944

406367 9256126 Minus 58313-58489

406400 9256298 Plus 1553-1712,1878-2140,42524385,5922 6077 Table 15A lists about 499 genes up-regulated in ovanan cancer compared to normal adult tissues that are likely to be extracellular or cell-surface proteins These were selected as for Table 14A, except that the ratio was greater than or equal to 30, and the predicted protein contained a structural domain that is indicative of extracellular localization (e g , ig, fn3, egf, 7tm domains) Predicted protein domains are noted

TABLE 15A ABOUT 499 UP-REGULATED GENES ENCODING EXTRACELLULAR/CELL SURFACE PROTEINS, OVARIAN CANCER VERSUS NORMAL ADULT TISSUES

Pkey Pπmekey

UG ID UπiGene lD

Title UniGene title

Prot Dom Predicted protein structural domains ratio ration tumor vs normal tissues

Pkey Ex Accn UGID Title Prot Dom ratio

415989 AI267700 Hs 111128 ESTs TM 427

428579 NM 005756 Hs 184942 G protein-coupled receptor 64 TM 305

428153 AW513143 Hs 98367 similar to SRY-box containing gene 17 TM 30 1

436982 AB018305 Hs 5378 spondin 1, (f-spondiπ) extracellular matrix SS 294

427585 D31152 Hs 179729 collagen, type X, alpha 1 (Schmid metaphy C1q,Collagen 270

430691 C14187 Hs 103538 ESTs TM 26 2

418007 M13509 Hs 83169 Matnx metalloprotease 1 (interstitial collag SS„Peptιdase M10 20 6

400292 AA250737 Hs 72472 BMPR-lb, bone morphogenetic protein rec TM 206

424086 AI351010 Hs 102267 lysyl oxidase Lysyl.oxidase 177

424905 NM.002497 Hs 153704 NIMA (never in mitosis gene a)-related kin pkise.pkmase 174

427356 AW023482 Hs 97849 ESTs TM 174

407638 AJ404672 Hs 288693 EST TM 17 1

427469 AA403084 Hs 269347 ESTs TM 170

438993 AA828995 integπn, beta 8 SS.mtegππ B 167

421155 H87879 Hs 102267 lysyl oxidase SS 161

431989 AW972870 Hs 291069 ESTs SS 159

428976 AL037824 Hs 194695 ras homolog gene family, member 1 ras 151

416209 AA236776 Hs 79078 MAD2 (mitotic arrest deficient, yeast, horn TM 150 413623 AA825721 Hs.246973 ESTs TM 14.8

447350 AI375572 Hs.172634 ESTs; HER4(oerb-B4) SS,TM,Furin-like,pkinase 14.2

428227 AA321649 Hs.2248 INTERFERON-GAMMA INDUCED PRO IL8 14.1

452461 N78223 Hs.108106 transcription factor G9a,PHD 13.7

451106 BE382701 Hs.25960 N-myc Myc N term 13.6

416208 AW291168 Hs.41295 ESTs TM 13.5

452249 BE394412 Hs.61252 ESTs homeobox 13.4

416566 NM 003914 Hs.79378 cyclin A1 cyclin 12.8

416661 AA634543 Hs.79440 IGF-II mRNA-binding protein 3 TM 12.6

431725 X65724 Hs.2839 Norrie disease (pseudoglioma) SS.Cys knot 12.3

458027 L49054 Hs.85195 ESTs, Highly similar to t(3;5)(q25.1;p34) f TM 12.2

408460 AA054726 Hs.285574 ESTs TM 12.2

415263 AA948033 Hs.130853 ESTs histone 11.9

400298 AA032279 Hs.61635 STEAP1 TM 11.8

421451 AA291377 Hs.50831 ESTs TM 11.6

443715 AI583187 Hs.9700 cyclin E1 cyclin 11.5

413472 BE242870 Hs.75379 solute earner family 1 (glial high affinity gl TM.SDF 11.5

410102 AW248508 Hs.279727 ESTs; SS 11.4

408562 AI436323 Hs.31141 Homo sapiens mRNA for KIAA1568 prate TM 11.4

442353 BE379594 Hs.49136 ESTs TM 11.3

427344 NM 000869 Hs.2142 5-hydroxytryptamine (serotonin) receptor 3 TM.πeur.chan 11.2

453160 AI263307 Hs.146228 ESTs histone 11.2

412723 AA648459 Hs.179912 ESTs TM 11.1

400250 0 HisLdeacetyl+F105 11.1

438167 R28363 Hs.24286 ESTs .. 7tm_1 11.1

434539 AW748078 Hs.214410 ESTs TM 10.9

450375 AA009647 Hs.8850 a disintegrin and metalloproteinase domain TM 10.8

400289 X07820 Hs.2258 Matrix Metalloproteinase 10 (Stromolysin 2 SS.hemopexin 10.8

446142 A1754693 Hs.145968 ESTs Cadherin C term 10.7

421285 NM 000102 Hs.1363 cytochrome P450, subfamily XVII (steroid TM,p450 10.6

433496 AF064254 Hs.49765 VERY-LONG-CHAIN ACYL-COA SYNT SS M 10.6

418506 AA084248 Hs.85339 G protein-coupled receptor 39 TM 10.5

433447 U29195 Hs.3281 neuronal pentraxin II SS 10.4

414245 BE148072 Hs.75850 WAS protein family, member 1 TM 10.3

426462 U59111 Hs.169993 dermatan sulphate proteoglycan 3 SS.LRRNT 10.3

418601 AA279490 Hs.86368 calmegin SS 10.3

415227 AW821113 Hs.72402 ESTs TM 10.2

409269 AA576953 Hs.22972 Homo sapiens cDNA FU13352 fis, clone O TM 10.1

426471 M22440 Hs.170009 transforming growth factor, alpha SS.EGF 9.8

407881 AW072003 Hs.40968 heparan sulfate (glucosamine) 3-O-suIfotran SS 9.7

445537 AJ245671 Hs.12844 EGF-like-domain; multiple 6 SS.EGF 9.7

414972 BE263782 Hs.77695 KIAA0008 gene product TM 9.4

435509 AI458679 Hs.181915 ESTs TM 9.3

445413 AA151342 Hs.12677 CGI-147 protein UPF0099 9.2

446999 AA151520 Hs.279525 hypothetical protein PRO2605 TM 9.1

414569 AF109298 Hs.118258 Prostate cancer associated protein 1 TM 9.1

406687 M31126 Hs.272620 pregnancy specific beta-1-glycoprotein 9 hemopexin 9.0

408908 BE296227 Hs.48915 serine/threoniπe kinase 15 pkise.TM 9.0

451807 W52854 Hs.27099 DKFZP564J0863 protein TM 8.8

420159 AI572490 Hs.99785 ESTs TM 8.8

432677 NM 004482 Hs.278611 UDP-N-acetyl-alpha-D-galactosamine:poly TM.Riciπ B lectin 8.7

408829 NM 006042 Hs.48384 heparan sulfate (glucosamine) 3-O-sulfotran TM 8.7

438885 AI886558 Hs.184987 ESTs TM 8.7

447342 AI199268 Hs.19322 ESTs; Weakly similar to III! ALU SUBFAM TM 8.6

437212 AI765021 Hs.210775 ESTs UDPGT 8.5

424717 H03754 Hs.152213 wingless-type MMTV integration site fami wnt 8.4

450505 NM 004572 Hs.25051 plakophilin 2 TM 8.4

436396 AI683487 Hs.299112 Homo sapiens cDNA FU11441 fis, clone H wnt 8.3

425695 NM 005401 Hs.159238 protein tyrosine phosphatase, non-receptor Y_phosphatase 8.3

447268 AI370413 Hs.36563 Homo sapiens cDNA: FU22418 fis, clone Ribosomal S8 8.2

400195 0 TM 8.1

424906 AI566086 Hs.153716 Homo sapiens mRNA for Hmob33 protein, TM 8.1

438202 AW169287 Hs.22588 ESTs TM 8.1

439759 AL359055 Hs.67709 Homo sapiens mRNA full length insert cDN TM 8.0

453102 NM 007197 Hs.31664 frizzled (Drosophila) homolog 10 TM,Fz,Frizzled 8.0

424001 W67883 Hs.137476 KIAA1051 protein TM 8.0

442655 AW027457 Hs.30323 ESTs TM 7.8

445657 AW612141 Hs.279575 ESTs 7tm_1 7.8

426320 W47595 Hs.169300 transforming growth factor, beta 2 SS,TGF-beta 7.8

412170 D16532 Hs.73729 very low density lipoprotein receptor TMJdl recepLb,EGF 7.6

436476 AA326108 Hs.53631 ESTs TM 7.6

414132 AI801235 Hs.48480 ESTs TM 7.6

437789 AI581344 Hs.127812 ESTs, Weakly similar to AF141326 1 RNA TM 7.6

450192 AA263143 Hs.24596 RAD51 -interacting protein TM 7.6

408826 AF216077 Hs.48376 Homo sapiens clone HB-2 mRNA sequence TM 7.5

413627 BE182082 Hs.246973 ESTs TM 7.4

446293 AI420213 Hs.149722 ESTs UM.homeobox 7.4

409242 AL080170 Hs.51692 DKFZP434C091 protein TM,7tm_1 7.3

450262 AW409872 Hs.271166 ESTs, Moderately similar to ALU7 HUMA TM 7.3

451659 BE379761 Hs.1 248 ESTs, Weakly similar to AUJβ.HUMAN A TM 7.3

444342 NM 014398 Hs.10887 similar to lysosome-associated membrane g TM 7.2

429126 AW172356 Hs.99083 ESTs 7tm_1 7.1

421464 AA291553 Hs.190086 ESTs TM 7.0

420362 U79734 Hs.97206 huntiπgtin interacting protein 1 TM 7.0 444743 AA045648 Hs 11817 nudix (nucleoside diphosphate linked moiet TM 70

415138 C18356 Hs 78045 tissue factor pathway inhibitor 2 TFPI2 Kunifz BPTI.G-gamma 69

429418 AI381028 Hs 99283 ESTs AAA 69

409178 BE393948 Hs 50915 kallikrein 5 SS.trypsin 69

425905 AB032959 Hs 161700 KIAA1133 protein TM 69

428532 AF157326 Hs 184786 TBP-mteractiπg protein TM 69

433426 H69125 Hs 133525 ESTs TM 69

448674 W31178 Hs 154140 ESTs TM 68

432415 T16971 Hs 289014 ESTs TM 67

418203 X54942 Hs 83758 CDC28 protein kinase 2 TM 66

438394 BE379623 Hs 27693 CGI-124 protein pro.isomerase 66

452097 AB002364 Hs 27916 ADAM-TS3 , a disintegπn like and metal Reprolysin 66

453745 AA952989 Hs 63908 Homo sapiens HSPC316 mRNA, partial cd TGFb_propeptιde 66

423248 AA380177 Hs 125845 πbulose 5-phosphate-3^pιmerase filament 66

452281 T93500 Hs 28792 ESTs TGF-beta 65

424620 AA101043 Hs 151254 kallikrein 7 (chymotryptic, stratum comeum SS.trypsin 65

452594 AU076405 Hs 29981 solute earner family 26 (sulfate transporter) TM.Sulfate.traπsp 65

434149 Z43829 Hs 19574 ESTs, Weakly similarto katanin p80 subun pkinase,fn3 65

425776 U25128 Hs 159499 parathyroid hormone receptor 2 TM,7tm_2 64

409517 X90780 Hs 54668 troponin I, cardiac Y_phosphatase 64

432666 AW204069 Hs 129250 ESTs, Weakly similar to unnamed protein p TM 64

448706 AW291095 Hs 21814 class II cytokine receptor ZCYTOR7 SS 64

413582 AW295647 Hs 71331 Homo sapiens cDNA FU21971 fis, clone TM 64

424153 AA451737 Hs 141496 MAGE-hke 2 TM 64

441081 AI584019 Hs 169006 ESTs, Moderately similar to plakophilm 2b PAX 64

443539 AI076182 Hs 134074 ESTs TM 64

418384 AW149266 Hs 25130 ESTs TM 63

425371 D49441 Hs 155981 mesothel SS 63

449048 Z45051 Hs 22920 similar to S68401 (cattle) glucose induced g SS 63

437117 AL049256 Hs 122593 ESTs TM 63

453370 AI470523 Hs 182356 ESTs, Moderately similar to translation mit ABC tran 63

426514 BE616633 Hs 301122 bone morphogenetic protein 7 (osteogenic p SS TGF-beta 63

452904 AL157581 Hs 30957 Homo sapiens mRNA, cDNA DKFZp434E TM 62

457030 AI301740 Hs 173381 dihydropyπmid ase like 2 TM 62

436281 AW411194 Hs 120051 ESTs TM 61

415139 AW975942 Hs 48524 ESTs TM 61

449448 D60730 Hs 57471 ESTs TM 61

457979 AA776655 Hs 270942 ESTs TM 61

422867 L32137 Hs 1584 cartilage oligomeric matrix protein SS.EGF.tsp 3 60

421502 AF111856 Hs 105039 solute earner family 34 (sodium phosphate) TM 60

412733 AA984472 Hs 74554 KIAA0080 protein C2 60

422095 AI868872 Hs 288966 ceruloplasmm (ferroxidase) SS 60

418845 AA852985 Hs 89232 chromobox homolog 5 (Drosophila HP1 alp Chromo.shadow 60

410555 U92649 Hs 64311 a disintegπn and metalloprote ase domain TM,dιsιntegπn,Reprolysιn 59

437099 N77793 Hs 48659 ESTs, Highly similar to LMA1.HUMAN L laminm.EGF 59

453431 AF094754 Hs 32973 glycme receptor, beta TM.neur chan 59

417866 AW067903 Hs 82772 "collagen, type XI, alpha 1" TSPN,Collagen,COLFI 59

430291 AV660345 Hs 238126 CG149 protein TM 59

405547 #{N0CAT) 0 TM ABC membrane 59

435793 AB037734 Hs 4993 ESTs TM 58

440138 AB033023 Hs 6982 hypothetical protein FU10201 TM 58

425154 NM.001851 Hs 154850 collagen, type IX, alpha 1 SS.Collagen.TSPN 57

419335 AW960146 Hs 284137 Homo sapiens cDNA FLJ 12888 fis, clone N TM 57

452971 AI873878 Hs 91789 ESTs TM 57

428927 AA441837 Hs 90250 ESTs TM 57

419247 S65791 Hs 89764 fragile X mental retardation 1 TM 57

445640 AW969626 Hs 31704 ESTs, Weakly similar to KIAA0227 [H sap TM 57

447078 AW885727 Hs 301570 ESTs kazal 56

421247 BE391727 Hs 102910 general traπscπption factor IIH, polypeptid TM 56

432030 AI908400 Hs 143789 ESTs SS 56

443270 NM.004272 Hs 9192 Homer, neuronal immediate early gene, 1B TM 55

411096 U80034 Hs 68583 mitochondnal intermediate peptidase Peptidase M3 55

419558 AW953679 Hs 278394 ESTs SS 55

427386 AW836261 Hs 177486 amyloid beta (A4) precursor protein (protea TM 55

427961 AW293165 Hs 143134 ESTs TM 55

407216 N91773 Hs 102267 lysyl oxidase TM 55

413930 M86153 Hs 75618 RAB11 A, member RAS oncogene family ras.TM 55

414315 Z24878 gb HSB65D052 STRATAGENE Human sk TM 55

441645 AI222279 Hs 201555 ESTs SS 55

449318 AW236021 Hs 108788 ESTs, Weakly similar to zeste [D melaπoga TM 54

441433 AA933809 Hs 42746 ESTs TM 54

445495 BE622641 Hs 38489 ESTs I.LWEQ.ENTH 54

410153 BE311926 Hs 15830 Homo sapiens cDNA FLJ12691 fis, clone N Glycos transf 2 54

442611 BE077155 Hs 177537 ESTs TM 54

452401 NM 07115 Hs 29352 tumor necrosis factor, alpha-induced protein Xlιnk,CUB 54

419948 AB041035 Hs 93847 NADPH oxidase 4 TM 53

427718 AI798680 Hs 25933 ESTs histone 53

453867 AI929383 Hs 108196 HSPC037 protein TM 53

408298 AI745325 Hs 271923 ESTs, Moderately similar to mi ALU SUB Glycos transf 2,DSPc 53

448543 AW897741 Hs 21380 Homo sapiens mRNA, cDNA DKFZp586P TM 53

433222 AW514472 Hs 238415 ESTs, Moderately similar to ALU8 HUMA TM 53

449532 W74653 Hs 271593 ESTs TM 53

452822 X85689 Hs 288617 Homo sapiens cDNA FU22621 fis, clone TM,EGF,fπ3 53

418379 AA218940 Hs 137516 fidgetin-like 1 AAA 52 416530 U62801 Hs 79361 kallikrein 6 (neurosin, zyme) TM.frypsm 52

413384 NM 000401 Hs 75334 exostoses (multiple) 2 TM 52

445236 AK001676 Hs 12457 hypothetical protein FU10814 TM 52

406367 #(NOCAT) 0 proteasome.trypsin 52

442500 AI819068 Hs 209122 ESTs SS 52

450101 AV649989 Hs 24385 Human hbc647 mRNA sequence TM 52

419140 AI982647 Hs 215725 ESTs TM 52

417791 AW965339 Hs 111471 ESTs Ald.Xan.dh_C 51

437496 AA452378 Hs 170144 Homo sapiens mRNA, cDNA DKFZp547J1 TSPN.Folate earner 51

10 418849 AW474547 Hs 53565 ESTs, Weakly similar to B0491 1 [C elegan TM 5 1

428093 AW594506 Hs 104830 ESTs TM 5 1

408621 AI970672 Hs 46638 chromosome 11 open reading frame 8, feta TM 5 1

418852 BE537037 Hs 273294 hypothetical protein FU20069 TM 5 1

404939 0 TM 50

15 447020 T27308 Hs 16986 hypothetical protein FU11046 TM 50

410824 AW994813 Hs 33264 ESTs TM 50

417423 AA197341 Hs 111164 ESTs TM 50

421477 AI904743 Hs 104650 hypothetical protein FU 10292 TM 50

443555 N71710 Hs 21398 ESTs, Moderately similar to GNPI.HUMA Glucosamiπejso 50

20. 424539 L02911 Hs 150402 xtivm A receptor, type I SS.Activin recp.pkmase 49

416565 AW000960 Hs 44970 ESTs TM 49

431130 NM.006103 Hs 2719 epididymis-specific, whey-acidic protein ty SS 49

408938 AA059013 Hs 22607 ESTs TM 49

436754 AI061288 Hs 133437 ESTs, Moderately similar to gonadotropin i TM 49

25 409049 AI423132 Hs 146343 ESTs ^ TM 49

458627 AW088642 Hs 97984 ESTs, Weakly similarto WASP-family pro TM 48

418882 NM.004996 Hs 89433 ATP-binding cassette, sub-family C (CFTR TM.ABC membrane 48

422505 AL120862 Hs 124165 ESTs, (HSA)PAP protein (programmed ce TM 48

428555 NM 002214 Hs 184908 integπn, beta 8 SS.integπn B 48

30 452909 NM 015368 Hs 30985 pannexm 1 TM 48

449535 W15267 Hs 23672 low density lipoprotein receptor-related pro SS.Idl recepLa.EGF 48

452232 AW020603 Hs 271698 ESTs TM 48

423161 AL049227 Hs 124776 Homo sapiens mRNA, cDNA DKFZp564N Cadhenn.C.term 47

428405 Y00762 Hs 2266 cholmergic receptor, nicotinic, alpha polype TM.neur chan 47

35 433330 AW207084 Hs 132816 ESTs TM 47

443933 AI091631 Hs 135501 Homo sapiens two pore potassium channel TM 47

440351 AF030933 Hs 7179 RAD1 (S pombe) homolog TM 47

426300 U15979 Hs 169228 delta-like homolog (Drosophila) TM.EGF 47

453775 NM 002916 Hs 35120 replication factor C (activator 1) 4 (37kD) AAA,DEAD,helιcase C 47

40 429944 R13949 Hs 226440 Homo sapiens clone 24881 mRNA sequeπc TM 47

434988 AI418055 Hs 161160 ESTs TM 46

406400 #(NOCAT) 0 trypsm.TM 46

428301 AW628666 Hs 98440 ESTs TM 46

446254 BE179829 Hs 179852 Homo sapiens cDNA FU12832 fis, clone N TM 46

45 459574 AI741122 Hs 101810 Homo sapiens cDNA FU 14232 fis, clone N TM 46

409928 AL137163 Hs 57549 hypothetical protein dJ473B4 TM 46

435244 N77221 Hs 187824 ESTs pkιnase,fn3 46

404996 #(NOCAT) 0 Peptιdase_C1 46

407905 AW103655 Hs 252905 ESTs SS.Ephπn 46

50 441675 AI914329 Hs 5461 ESTs TM 46

420276 AA290938 Hs 190561 ESTs, Highly similar to mosaic protein LR1 TM,fn3,ldl recept a 45

422529 AW015128 Hs 256703 ESTs TM 45

438018 AK001160 Hs 5999 hypothetical protein FLJ 10298 TM 45

457465 AW301344 Hs 195969 ESTs Pπbosyltran 45

55 418848 AI820961 Hs 193465 ESTs TM.pkise 45

447499 AW262580 Hs 147674 KIAA1621 protein TM 45

432731 R31178 Hs 287820 fibronectin 1 SS 45

434699 AA643687 Hs 149425 Homo sapiens cDNA FU11980 fis, clone H Nucleoside tra2 44

427528 AU077143 Hs 179565 minichromosome maintenance deficient (S TM 44

60 409092 AI735283 Hs 172608 ESTs TM 44

451389 N73222 Hs 21738 KIAA1008 protein TM 44

453331 AI240665 Hs 8895 ESTs TM 44

448133 AA723157 Hs 73769 folate receptor 1 (adult) TM 44

429597 NM 003816 Hs 2442 a disintegπn and metalloprotemase domain TM 44

65 453279 AW893940 Hs 59698 ESTs TM 44

409459 D86407 Hs 54481 low density lipoprotein receptor-related pro TM,EGF,ldl recept a 44

431708 AI698136 Hs 108873 ESTs TM 44

433906 AI167816 Hs 43355 ESTs TM 44

441423 A1793299 Hs 126877 ESTs TM 44

70 446770 AV660309 Hs 154986 ESTs, Weakly similar to AF137386 1 plasm TM 43

412078 X69699 Hs 73149 paired box gene 8 TM 43

423123 NM 012247 Hs 124027 SELENOPHOSPHATE SYNTHETASE , H AIRS 43

448390 AL035414 Hs 21068 hypothetical protein TM 43

453628 AW243307 Hs 170187 ESTs TM 43

75 452367 U71207 Hs 29279 eyes absent (Drosophila) homolog 2 TM 43

413775 AW409934 Hs 75528 nucleolar GTPase MMR.HSR1 43

451592 AI805416 Hs 213897 ESTs TM 43

419311 AA689591 gb nv66a12 s1 NCI.CGAP.GCB1 Homo s TM 42

452943 BE247449 Hs 31082 hypothetical protein FU 10525 TM 42

80 428679 AA431765 gb zw80c03 s1 Soares.testis.NHT Homo s TM 42

436209 AW850417 Hs 254020 ESTs, Moderately similar to unnamed prate TM 42

406076 AL390179 Hs 137011 Homo sapiens mRNA, cDNA DKFZp547P TM 42

428819 AL135623 Hs 193914 KIAA0575 gene product TM 42

406671 AA129547 Hs 285754 met proto-oncogene (hepatocyte growth fac F-actιn_cap_A 42 431750 AA514986 Hs 283705 ESTs TM 42

449554 AA682382 Hs 59982 ESTs TM 42

409073 AA063458 gb zf71a07s1 Soares_pιneal_gland N3HP SEA 41

433929 AI375499 Hs 27379 ESTs TM 41

415457 AW081710 Hs 7369 ESTs, Weakly similar to ALU1 HUMAN A TM 41

444381 BE387335 Hs 283713 ESTs TM 4 1

415539 AI733881 Hs 72472 BMPR-lb, bone morphogenetic protein rec TM 41

421515 Y11339 Hs 105352 GalNAc alpha-2, 6-sιalyltransferase 1, long TM 41

453293 AA382267 Hs 10653 ESTs TM 41

409564 AA045857 Hs 54943 fracture callus 1 (rat) homolog TM 41

429628 H09604 Hs 13268 ESTs TM 41

440452 AI925136 Hs 55150 ESTs, Weakly similar to CAYP.HUMAN TM 41

443695 AW204099 Hs 112759 ESTs, Weakly similar to AF126780 1 retina TM 41

425322 U63630 Hs 155637 protein kinase, DNA-activated, catalytic po TM 4 1

417300 AI765227 Hs 55610 solute camerfamily 30 (zinc transporter), m TM 41

417389 BE260964 Hs 82045 Midkme (neuπte growth-promoting factor 2 SS.TM 41

452834 AI638627 Hs 105685 ESTs kinesm 4 1

428771 AB028992 Hs 193143 KIAA1069 protein PI-PLC-X.PI-PLC-Y 40

412314 AA825247 Hs 250899 heat shock factor binding protein 1 TM 40

436291 BE568452 Hs 5101 ESTs, Highly similar to protein regulating c TM 40

450654 AJ245587 Hs 25275 Kruppel-type zinc finger protein KRAB 40

409365 AA702376 Hs 226440 Homo sapiens clone 24881 mRNA sequenc TM 40

413374 NM 001034 Hs 75319 πbonucleotide reductase M2 polypeptide πbonuc red 40

417655 AA780791 Hs 14014 ESTs, Weakly similar to KIAA0973 protein TM 40

445941 AI267371 Hs 172636 ESTs ., TM,lectιn_c 40

441134 W29092 Hs7678 cellular reϊnoic acid-binding protein 1 lipocalin 40

411630 U42349 Hs 71119 Putative prostate cancer tumor suppressor TM 40

418301 AW976201 Hs 187618 ESTs TM 40

411945 AL033527 Hs 92137 v-myc avian myelocytomatosis viral oncog TGF-beta, Myc N.term 40

408684 R61377 Hs 12727 hypothetical protein FU21610 TM 40

414869 AA157291 Hs 72163 ESTs TM 40

420281 AI623693 Hs 191533 ESTs Cation efflux 39

416658 U03272 Hs 79432 fibπllm 2 (congenital contractural arachnod EGF.TB 39

411274 NM 002776 Hs 69423 kallikrein 10 trypsm M 39

437222 AL117588 Hs 299963 ESTs TM 39

431958 X63629 Hs 2877 Cadhenn 3, P-cadheπn (placental) TM.cadheπn, 39

430634 AI860651 Hs 26685 ESTs TM 39

415716 N59294 Hs 301141 Homo sapiens cDNA FU11689 fis, clone H NAP.family 39

420179 N74530 Hs 21168 ESTs TM 38

451250 AA491275 Hs 236940 Homo sapiens cDNA FU12542 fis, clone N TM 38

429496 AA453800 Hs 192793 ESTs TM 38

421764 AI681535 Hs 99342 ESTs, Weakly similar to KCC1.HUMAN C TM 38

447197 R36075 gb yh88b01 s1 Soares placenta Nb2HP Horn TM.SDF 38

422939 AW394055 Hs 98427 ESTs TM 38

414737 AI160386 Hs 125087 ESTs TM 38

411773 NM 006799 Hs 72026 protease, seπne, 21 (testism) SS.trypsin 38

425247 NM 005940 Hs 155324 matπx metalloprotemase 11 (stromelysin 3) SS.Peptidase M10 37

424433 H04607 Hs 9218 ESTs TM 37

431846 BE019924 Hs 271580 Uroplakin 1B TM,transmembrane4 37

407792 AI077715 Hs 39384 putative secreted ligand homologous to fjx1 SS 37

417531 NM 003157 Hs 1087 seπne/threonme kmase 2 pkise.pkinase 37

434836 AA651629 Hs 118088 ESTs TM 37

439810 AL109710 Hs 85568 EST TM 37

418693 AI750878 Hs 87409 thrombospoπdin 1 SS.EGF.TSPN 37

407864 AF069291 Hs 40539 chromosome 8 open reading frame 1 TM 37

436304 AA339622 Hs 108887 ESTs TM 37

452259 AA317439 Hs 28707 signal sequence receptor, gamma (transloco TM 37

453468 W00712 Hs 32990 DKFZP566F084 protein TM 36

428943 AW08618O Hs 37636 ESTs, Weakly similar to KIAA1392 protein TM 36

411402 BE297855 Hs 69855 NRAS-related gene CSD.ras.CSD 36

425176 AW015644 Hs 301430 ESTs, Moderately similar to TEF1.HUMA TM 36

400296 AA305627 Hs 139336 ATP-binding cassette, sub-family C (CFTR ABC tran 36

407340 AA810168 Hs 232119 ESTs TM 36

418524 AA300576 Hs 85769 acidic 82 kDa protein mRNA TM 36

438279 AA805166 Hs 165165 ESTs, Moderately similar to ALU8.HUMA TM 36

439453 BE264974 Hs 6566 thyroid hormone receptor mteractor 13 AAA,AAA 36

441111 AI806867 Hs 126594 ESTs TM 36

451806 NM.003729 Hs 27076 RNA 3'-termιnal phosphate cyclase TM 36

409542 AA503020 Hs 36563 ESTs Rιbosomat_S8 36

425441 AA449644 Hs 193063 Homo sapiens cDNA FU14201 fis, clone N Aa trans 36

428137 AA421792 Hs 170999 ESTs AAA 36

433692 AI805860 Hs 208675 ESTs, Weakly similarto neuronal thread pr TM 36

438689 AW129261 Hs 250565 ESTs TM 36

443341 AW631480 Hs 8688 ESTs TM 36

446261 AA313893 Hs 13399 hypothetical protein FU 12615 similarto m ATP-synLD,PH 36

414343 AL036166 Hs 75914 coated vesicle membrane protein TM 35

414812 X72755 Hs 77367 monokine induced by gamma interferon SSJL8 35

410361 BE391804 Hs 62661 guanylate binding protein 1, interferon mdu TM 35

415786 AW419196 Hs 257924 ESTs TM 35

427177 AB006537 Hs 173880 interteukin 1 receptor accessory protein TM,ιg 35

427687 AW003867 Hs 112403 ESTs 7tm_1 35

444619 BE538082 Hs 8172 ESTs TM 35

447336 AW139383 Hs 245437 ESTs AhpC-TSA 35

412519 AA196241 Hs 73980 troponm T1, skeletal, slow TM 35 418792 AB037805 Hs 88442 KIAA1384 protein TM 35

408031 AA081395 Hs 42173 Homo sapiens cDNA FU10366 fis, clone N TM 35

416892 L24498 Hs 80409 growth arrest and DNA-damage-mducible, TM 35

418793 AW382987 Hs 88474 prostaglandin-endoperaxide synthase 1 (pro EGF 35

448089 AI467945 Hs 173696 ESTs SS 35

422278 AF072873 Hs 114218 ESTs TM,Fz,Fπzzled 35

442133 AW874138 Hs 129017 ESTs TM 35

410908 AA121686 Hs 10592 ESTs GTP EFTU 35

452198 AI097560 Hs 61210 ESTs TM 35

408730 AV660717 Hs 47144 DKFZP586N0819 protein pkinase 34

436488 BE620909 Hs 261023 hypothetical protein FLJ20958 TM 34

409745 AA077391 gb 7B14E12 Chromosome 7 Fetal Brain cD TM 34

445870 AW410053 Hs 13406 syπtaxin 18 TM 34

451743 AW074266 Hs 23071 ESTs TM 34

407846 AA426202 Hs 40403 Cbp/p300-ιnteractιng transxtivator, with G TM 34

432350 NM 005865 Hs 274407 protease, seπne, 16 (thymus) SS 34

412848 AA121514 Hs 70832 ESTs TM 34

413625 AW451103 Hs 71371 ESTs filament 34

417801 AA417383 Hs 82582 integπn, beta-like 1 (with EGF-like repeat d SS 34

422972 N59319 Hs 145404 ESTs TM 34

429170 NM.001394 Hs 2359 dual specificity phosphatase 4, MAP kmas DSPc.Rhodanese 34

450377 AB033091 Hs 24936 ESTs TM 34

443475 AI066470 Hs 134482 ESTs TM 34

419452 U33635 Hs 90572 PTK7 protein tyrosine kinase 7 TM,pkιse,ιg,SRF-TF 34

409744 AW675258 Hs 56265 Homo sapiens mRNA, cDNA DKFZp586P TM 34

422789 AK001113 Hs 120842 hypothetical protein FU10251 TM 34

404440 #(NOCAT) 0 TM.neur.chan 34

417412 X16896 Hs 82112 interleukin 1 receptor, type I SS,TIR,ιg 34

411828 AW161449 Hs 72290 wingless-type MMTV integration site fa i wnt 34

417177 NM.004458 Hs 81452 fatty-acid-Coenzyme A ligase, long-chain 4 SS 34

421013 M62397 Hs 1345 mutated in colorectal cancers TM 34

427072 H38046 gb yp58c10 r1 Soares fetal liver spleen 1 NF Rιbosomal_L22e 34

433703 AA210863 Hs 3532 nemo like kinase pkinase 34

434294 AJ271379 Hs 21175 ESTs TM 34

444188 AI393165 Hs 19175 ESTs TM 34

446109 N67953 Hs 145920 ESTs TM 34

400881 0 Asparagmase 2 33

450236 AW162998 Hs 24684 KIAA1376 protein TM 33

418836 AI655499 Hs 161712 ESTs TM 33

437951 T34530 Hs 4210 Homo sapiens cDNA FU 13069 fis, clone N TM 33

446896 T15767 Hs 22452 Homo sapiens cDNA FU21084 fis, clone TM 33

430687 BE274217 Hs 249247 heterogeneous nuclear protein similar to rat rrm 33

410060 NM 001448 Hs 58367 glypιcan4 SS 33

419546 AA244199 gb nc06c05 s1 NCI.CGAP.Pr1 Homo sapi TM 33

429609 AF002246 Hs 210863 cell adhesion molecule with homology to L TM,fn3,ιg 33

413289 AA128061 Hs 114992 ESTs TM 33

440006 AK000517 Hs 6844 hypothetical protein FLJ20510 TM 33

401435 #(NOCAT) 0 TM 33

420072 AW961196 Hs 207725 ESTs TM 33

421426 AA291101 Hs 33020 Homo sapiens cDNA FU20434 fis, clone K TM 33

425851 NM.001490 Hs 159642 glucosaminyl (N-acetyl) fransferase 1, core SS 33

443295 AI049783 Hs 241284 ESTs TM 32

453116 AI276680 Hs 146086 ESTs Ribosomal L5 C 32

456546 AI690321 Hs 203845 ESTs, Weakly similar to TWIK-related acid TM 32

430016 NM 004736 Hs 227656 xenotropio and polyfropic retrovirus recepto TM 32

418281 U09550 Hs 1154 oviductal glycoprotein 1, 120kD (muc 9, asp.Glyco hydro 18 32

433800 AI034361 Hs 135150 lung type-l cell membrane-associated glyco TM 32

425159 NM.004341 Hs 154868 carbamoyl-phosphate synthetase 2, aspartat TM 32

428882 AA436915 Hs 131748 ESTs, Moderately similar to ALU7.HUMA carb anhydrase 32

409533 AW969543 Hs 21291 mitogen-xtivated protein kinase kinase km TM 32

411248 AA551538 Hs 69321 KIAA1359 protein TM 32

421379 Y15221 Hs 103982 small inducible cytokine subfamily B (Cys- SS.IL8 32

430259 BE550182 Hs 127826 RalGEF-like protein 3, mouse homolog TM 32

414945 BE076358 Hs 77667 lymphocyte antigen 6 complex, locus E SS 32

444471 AB020684 Hs 11217 KIAA0877 protein TM 32

421674 T10707 Hs 296355 neuronal PAS domain protein 2 Ribosomal L31e 32

434163 AW974720 Hs 25206 ESTs TM 32

421991 NM 014918 Hs 110488 KIAA0990 protein SS 32

409589 AW439900 Hs 256914 ESTs TM 32

414147 BE091634 gb IL2-BT0731-240400-069-C03 BT0731 TM 32

414661 T97401 Hs 21929 ESTs TM 32

437537 AA758974 Hs 121417 ESTs, Weakly similar to unnamed protein p TM 32

439702 AW085525 Hs 134182 ESTs A2M 31

420552 AK000492 Hs 98806 hypothetical protein TM 31

441028 AI333660 Hs 17558 ESTs ICE_p20,CARD 31

425264 AA353953 Hs 20369 ESTs, Weakly similar to gonadotropin indu TM 31

422109 S73265 Hs 1473 gastπn releasing peptide SS.Bombesin 31

441859 AW194364 Hs 128022 ESTs, Weakly similar to FIG1 MOUSE FIG TM 31

415451 H19415 Hs 268720 ESTs, Moderately similar to ALU1.HUMA SS.Ephπn 3 1

447866 AW444754 Hs 211517 ESTs homeobox 31

419978 NM 001454 Hs 93974 forkhead boxJI Fork head 31

446219 AI287344 Hs 149827 ESTs MIP 3 1

448428 AF282874 Hs 21201 nectm 3, DKFZP566B0846 protein TM,ιg 3 1

407615 AW753085 gb PM1-CT0247-151299-005-a03 CT0247 TM 31 410518 AW976443 Hs 285655 ESTs RasGEF.PH.RhoGEF 31

418396 AI765805 Hs 26691 ESTs TM 31

427855 R61253 Hs 98265 ESTs TM 3 1

429272 W25140 Hs 110667 ESTs TM 31

450171 AL133661 Hs 24583 hypothetical protein DKFZp434C0328 TM 31

414774 X02419 Hs 77274 plasminogen activator, urokmase SS.kππgle.trypsin 31

422363 T55979 Hs 115474 replication factor C (activator 1) 3 (38kD) TM 31

420062 AW411096 Hs 94785 hypothetical protein LOC57163 TM 3 1

428698 AA852773 Hs 297939 ESTs, Weakly similar to neogenm [H sapie TM 3 1

427051 BE178110 Hs 173374 ESTs TM 3 1

428242 H55709 Hs 2250 leukemia inhibitory factor (cholmergic diffe SS 31

452906 BE207039 Hs 75621 seππe (or cysteine) prateinase inhibitor, a TM 31

429419 AB023226 Hs 202276 KIAA1009 protein TM 31

417517 AF0Q1176 Hs 82238 POP4 (processing of precursor, S cerevisia TM 31

406137 #(N0CAT) 0 TM 31

424800 AL035588 Hs 153203 MyoD family inhibitor TM 31

410252 AW821182 Hs 61418 micrafibnllar-associated protein 1 TM 31

420392 AI242930 Hs 97393 KIAA0328 protein SS 31

423629 AW021173 Hs 18612 Homo sapiens cDNA FU21909 fis, clone voltage.CLC.CBS 31

429334 D63078 Hs 186180 Homo sapiens cDNA FU23038 fis, clone Glyco hydro 2 31

449802 AW901804 Hs 23984 hypothetical protein FU20147 TM 31

450506 NM.004460 Hs 418 fibroblast activation protein, alpha SS.Peptidase S9 30

433849 BE465884 Hs 280728 ESTs TM 30

411984 NM.005419 Hs 72988 signal transducer and activator of traπscπpt SH2.STAT 30

422530 AW972300 Hs 118110 bone marrgw stromal cell antigen 2 TM 30

422128 AW881145 gb QV0 OT0033-010400-182-a07 OT0033 TM 30

409757 NM.001898 Hs 123114 cystatin SN SS.cystatm 30

418727 AA227609 Hs 94834 ESTs TM 30

422244 Y08890 Hs 113503 karyopheπn (imporlin) beta 3 TM 30

456844 AI264155 Hs 152981 CDP-diacylglycerol synthase (phosphatidat TM 30

432358 AI093491 Hs 72830 ESTs SS 30

416896 AI752862 Hs 5638 KIAA1572 protein BTB 30

447312 AI434345 Hs 36908 activating transcription factor 1 TM 30

445021 AK002025 Hs 12251 Homo sapiens cDN A FU 11163 fis, clone P TM 30

422611 AA158177 Hs 118722 fucosyltransferase 8 (alpha (1,6) fucosyltran SS 30

453597 BE281130 Hs 33713 myo-mositol 1-phosphate synthase A1 TM 30

401197 #(N0CAT) 0 arf.Ets 30

403000 BE247275 Hs 151787 U5 snRNP-specific protein, 116 kD TM 30

410008 AA079552 gb zm20h12 s1 Stratagene pancreas (93720 TM.FG GAP 30

413268 AL039079 Hs 75256 regulator of G-protem signalling 1 RGS 30

414080 AA135257 Hs 47783 ESTs, Weakly similar to T12540 hypotheti TM 30

426882 AA393108 Hs 97365 ESTs TM 30

427651 AW405731 Hs 18498 Homo sapiens cDNA FU12277 fis, clone M TM 30

439444 AI277652 Hs 54578 ESTs TM 30

433001 AF217513 Hs 279905 clone HQ0310 PRO0310p1 TM 30

444895 AI674383 Hs 301192 EST cluster (not in UniGene) TMASC 30

441962 AW972542 Hs 289008 Homo sapiens cDNA FU21814 fis, clone TM 30

414725 AA769791 Hs 120355 Homo sapiens cDNA FU13148 fis, clone N TM,7tm 1 30

434241 AF119913 Hs 283607 hypothetical protein PRO3077 SS 30

424962 NM.012288 Hs 153954 TRAM like protein TM 30

411987 AA375975 Hs 183380 ESTs, Moderately similar to ALU7.HUMA TM 30

421977 W94197 Hs 110165 πbosomal protein L26 homolog TM 30

436481 AA379597 Hs 5199 HSPC150 protein similar to ubiquitm-conju TM 30

407872 AB039723 Hs 40735 fπzzled (Drosophila) homolog 3 TM,7tm 2,Fz,Fπzzled 30

442577 AA292998 Hs 163900 ESTs TM 30

416120 H46739 gb yo14h02 s1 Soares adult brain N2b5HB5 TM 30

443775 AF291664 Hs 204732 matπx metalloprotemase 26 TM,Peptιdase M10,7tm_1 30

414664 AA587775 Hs 66295 Homo sapiens HSPC311 mRNA, partial cd TM 30

457590 AI612809 Hs 5378 spondin 1, (f-spondin) extracellular matπx SS 30

418946 AI798841 Hs 132103 ESTs TM 30

457940 AL360159 Hs 30445 Homo sapiens mRNA full length insert cDN TM,SPRY,7tm 1 30

TABLE 15B

Pkey Unique Eos probeset identifier number CAT number Gene cluster number

Accession Genbank accession numbers

Pkey CAT Number Accession

407615 1005404 1 AW753085AW753082AW054744AW753107AW753087 409073 109851 ? AA063458 AA063018 A1444822

409745 115237 1 AA077391 AI347618 A1361453 AI088754 AW207491 AW960912AA921874AA286833AA150722 BE152353AW188822 BE152450

410008 116812.1 AA079552 BE142525 BE142527

414147 142127.-1 BE091634

414315 143512 1 Z24878 AA494098 F13654AA494040 AA143127 416120 1571266.1 H46739H51513 H19779

419311 183793.1 AA689591 AW974261 AA236240 AI077451 AA631399 AW974262

419546 185766.1 AA244199 AA244272 H57440

422128 211994.1 AW881145AA490718 M85637AA304575T06067AA331991

427072 274884.1 H38046 W69645 AA397968 H38047 428679 294049.1 AA431765 AA432015

438993 467651.1 AA828995 AA834879 AI926361

447197 711623 1 R36075 AI366546 R36167 TABLE 15C

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham I et al " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489495 Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons

Pkey Ref Strand Nt position

400881 2842777 Minus 91446-91603,92123-92265

401197 9719705 Plus 176341-176452

401435 8217934 Minus 54508-55233

404440 7528051 Plus 80430 81581

404939 6862697 Plus 175318-175476

404996 6007890 Plus 37999-38145,38652-38998,39727-39872,4055740674,4235142450

405547 1054740 Plus 124361-124520,124914-125050

406137 9166422 Minus 30487-31058

406367 9256126 Minus 58313-58489

406400 9256298 Plus 1553-1712,1878-2140,42524385,5922-6077

Table 16A lists about 92 genes up-regulated in mucmous-type ovanan cancer compared to normal adult tissues These were selected as for Table 14A, except that the "average" ovanan cancer level was set to the 75th percentile amongst vaπous mucmous-type ovarian cancers, and the tumor/normal tissue ratio was greater than or equal to 25

TABLE 16A ABOUT 92 UP-REGULATED GENES, MUCINOUS OVARIAN CANCER VERSUS NORMAL ADULT TISSUES

Pkey Pπmekey -j

Ex Accn Exemplar Accession

UG ID UniGene lD

Title UniGene title

Prot Dom Predicted protein domain structure ratio ratio tumor vs normal tissues

Pkey Ex Accn UG ID Title Prot Dom ratio

430691 C14187 Hs 103538 ESTs 349

432938 T27013 Hs 3132 steroidogenic acute regulatory protein START 28 0

418007 M13509 Hs 83169 Matrix metalloprotease 1 (interstitial collag SS,Peptιdase_M10 223

451181 AI796330 Hs 207461 ESTs 108

452838 U65011 Hs 30743 Preferentially expressed antigen in melaπom 10 0

407638 AJ404672 Hs 288693 EST 93

450159 AI702416 Hs 200771 ESTs, Weakly similar to CAN2 HUMAN 92

426890 AA393167 Hs 41294 ESTs 9 1

421155 H87879 Hs 102267 lysyl oxidase SS.Lysyl.oxldase 89

437099 N77793 Hs 48659 ESTs, Highly similar to LMA1 HUMAN L laminm.EGF 76

453866 AW291498 Hs 250557 ESTs 76

435496 AW840171 Hs 265398 ESTs, Weakly similar to transformation rel 74

418738 AW388633 Hs 6682 solute earner family 7, member 11 72

431956 AK002032 Hs 272245 Homo sapiens cDNA FU11170 fis, clone P RA 70

449579 AW207260 Hs 134014 prostate cancer associated protein 6 67

424586 NM 003401 Hs 150930 X-ray repair complementing defective repa 67

445891 AW391342 Hs 199460 ESTs 62

424717 H03754 Hs 152213 wingless-type MMTV integration site fami wnt 6 1

452705 H49805 Hs 246005 ESTs 6 1

421285 NM 000102 Hs 1363 cytochrome P450, subfamily XVII (steroid TM,p450 55

408562 AI436323 Hs 31141 Homo sapiens mRNA for KIAA1568 prate 53

420159 AI572490 Hs 99785 ESTs 53

451105 AI761324 gb wι60b11 x1 NCI CGAP Co16 Homo s 52

409049 AI423132 Hs 146343 ESTs 50

448674 W31178 Hs 154140 ESTs TM 50

423811 AW299598 Hs 50895 homeo box C4 49

427469 AA403084 Hs 269347 ESTs 49

447033 AI357412 Hs 157601 EST- not UπiGene PH 49

424433 H04607 Hs 9218 ESTs 49

448811 AI590371 Hs 174759 ESTs TM 48

444330 AI597665 Hs 49265 ESTs 48

409041 AB033025 Hs 50081 KIAA1199 protein 47

418735 N48769 Hs 44609 ESTs 45

416661 AA634543 Hs 79440 IGF-II mRNA-bmding protein 3 KH-domaiπ 45

430073 U86136 Hs 232070 telomerase associated protein 1 WD40 44

407881 AW072003 Hs 40968 heparan sulfate (glucosamine) 3-0-sulfotran SS 44

422260 AA315993 Hs 105484 ESTs, Weakly simitar to LITHOSTATHIN 44

421110 AJ250717 Hs 1355 cathepsin E SS.asp 43

445676 AI247763 Hs 16928 ESTs 42

430704 AW813091 gb RC3-ST0186-240400-111-d07 ST0186 Epimerase 38

414569 AF109298 Hs 118258 Prostate cancer associated protein 1 TM 38

438078 AI016377 Hs 131693 ESTs 37

434032 AW009951 Hs 206892 ESTs 37

445657 AW612141 Hs 279575 ESTs 7tm_1 36

439759 AL359055 Hs 67709 Homo sapiens mRNA full length insert cDN 35

455666 BE065813 gb RC2-BT0318-110100-012-a08 BT0318 35

448844 AI581519 Hs 177164 ESTs 35

449048 Z45051 Hs 22920 similarto S68401 (cattle) glucose induced g SS 35

438018 AK001160 Hs 5999 hypothetical protein FU10298 TM 34

458123 AW892676 gb CM3-NN0004-280300-131-C12 NN0004 34

407385 AA610150 Hs 272072 ESTs, Moderately similar to ALU7.HUMA 34

424894 H83520 Hs 153678 reproduction 8 SS.UBX 33 424639 AI917494 Hs 131329 ESTs 33

414083 AL121282 Hs 257786 ESTs 32

426471 M22440 Hs 170009 transforming growth factor, alpha SS.EGF 32

428927 AA441837 Hs 90250 ESTs 3 1

406129 #(NOCAT) 0 TM,cNMP_bιπdιng 31

452699 AW295390 Hs 213062 ESTs 3 1

425842 AI587490 Hs 159623 NK-2 (Drosophila) homolog B homeo box 31

428976 AL037824 Hs 194695 ras homolog gene family, member 1 ras 3 1

436396 AI683487 Hs 299112 Homo sapiens cDNA FLJ11441 fis, clone H wnt 30

454077 AC005952 Hs 37062 insulin like 3 (Leydig cell) SS,lnsulιn,pkιnase 30

404253 #(NOCAT) 0 histone 29

452461 N78223 Hs 108106 transcπption factor G9a,PHD 29

429597 NM.003816 Hs 2442 a dismtegnn and metalloproteinase domain TM 29

413289 AA128061 Hs 114992 ESTs 29

429703 T93154 Hs 28705 ESTs 29

407829 AA045084 Hs 29725 Homo sapiens cDNA FLJ13197 fis, clone N 28

424796 AW298244 Hs 293507 ESTs 28

424086 A1351010 Hs 102267 lysyl oxidase Lysyl.oxidase 28

408427 AW194270 Hs 177236 ESTs 27

450375 AA009647 Hs 8850 a disintegπn and metalloprotemase domain 27

446999 AA151520 Hs 279525 hypothetical protein PRO2605 27

428819 AL135623 Hs 193914 KIAA0575 gene product 27

422956 BE545072 Hs 122579 ESTs 27

428949 AA442153 Hs 104744 ESTs, Weakly similar to AF208855 1 BM 0 27

426300 U15979 Hs 169228 delta-like homolog (Drosophila) TM.EGF 26

420380 AA640891 Hs 102406 ESTs 26

428651 AF196478 Hs 188401 annexin AIO TM.annexin 26

417849 AW291587 Hs 82733 Nidogen 2 EGFJdl recepLb 26

453700 AB009426 Hs 560 apolipoproteiπ B mRNA editing enzyme, ca TM 26

417975 AA641836 Hs 30085 Homo sapiens cDNA FLJ23186 fis, clone 26

448756 AI739241 Hs 171480 ESTs 26

425087 R62424 Hs 126059 ESTs 25

444153 AK001610 Hs 10414 hypothetical protein FLJ 10748 Kelch 25

443211 AI128388 Hs 143655 ESTs 25

415263 AA948033 Hs 130853 ESTs histone 25

432867 AW016936 Hs 233364 ESTs GSHPx 25

438639 AI278360 Hs 31409 ESTs 25

455386 AW935875 gb QV3-DT0019-120100-055-d06 DT0019 25

419092 J05581 Hs 89603 mucin l, transmembrane TM.SEA 25

452055 AI377431 Hs 293772 ESTs 25

TABLE 16B

Pkey Unique Eos probeset identifier number

CAT number Gene cluster number

Accession Genbank accession numbers

Pkey CAT Number Accession

430704 322217.1 AW813091 AW206655AA484440

451105 859083 1 AI761324 AW880941 AW880937

455386 1287756 1 AW935875 BE069116 BE160251

455666 1349545.1 BE065813 BE065788 BE065889 BE065832

458123 479942.1 AW892676 AA853877 D44747

TABLE 16C

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham 1 et al " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489495 Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons

Pkey Ref Strand NLposition

404253 9367202 Minus 55675-56055

406129 9160131 Plus 2567-3056

Table 17A lists about 183 genes up-regulated in endometπoid-type ovanan cancer compared to normal adult tissues These were selected as for Table 14A, except that the "average" ovanan cancer level was set to the 75th percentile amongst various endometπoid-type ovanan cancers, and the tumor/normal tissue ratio was greater than or equal to 25

TABLE 17A ABOUT 183 UP-REGULATED GENES, ENDOMETRIOID OVARIAN CANCER VERSUS NORMAL ADULT TISSUES

Pkey Pπmekey

Ex Accn Exemplar Accession

UG ID UniGene lD

Title UniGeπe title

Prat Dom Predicted protein domains ratio ratio tumor vs normal tissue

Pkey Ex Accn UG ID Title Prat Dom ratio

452838 U65011 Hs 30743 Preferentially expressed antigen in melanom 389

435094 AI560129 Hs 277523 EST

428153 AW513143 Hs 98367 hypothetical protein FU22252 similar to SR 241

428187 AI687303 Hs 285529 ESTs 239

449034 AI624049 gb ts41a09 x1 NCI.CGAP.Ut1 Homo sapi 199

453102 NM.007197 Hs 31664 frizzled (Drosophila) homolog 10 TM,Fz,Fπzzled 157 412925 AI089319 Hs 179243 ESTs 157

438817 AI023799 Hs 163242 ESTs 136

447033 AI357412 Hs 157601 EST- notm UniGene PH 135

433222 AW514472 Hs 238415 ESTs, Moderately similar to ALU8.HUMA 131

422956 BE545072 Hs 122579 ESTs 129

450451 AW591528 Hs 202072 ESTs 11 9

453964 A1961486 Hs 12744 ESTs homeobox 11 5

442438 AA995998 gb os26b03 s1 NCI CGAP Kidδ Homo sa 11 4

431989 AW972870 Hs 291069 ESTs SS 103

413623 AA825721 Hs 246973 ESTs 97

440901 AA909358 Hs 128612 ESTs 96

416661 AA634543 Hs 79440 IGF-II mRNA-bindmg protein 3 KH-domam 96

421478 AI683243 Hs 97258 ESTs 93

448706 AW291095 Hs 21814 class II cytokine receptor ZCYTOR7 SS.Tissue.fac 92

410566 AA373210 Hs 43047 Homo sapiens cDNA FU13585 fis, clone P 87

438993 AA828995 integπn, beta 8 SS.iπtegπn B 87

427121 AI272815 Hs 173656 KIAA0941 protein C2, 84

420610 AI683183 Hs 99348 distal less homeo box 5 homeobox 81

427356 AW023482 Hs 97849 ESTs 80

446577 AB040933 Hs 15420 KIAA1500 protein 80

431118 BE264901 Hs 250502 carbonic anhydrase VIII carb.anhydrase 75

448112 AW245919 Hs 301018 ESTs, Weakly similar to ALUB.HUMAN 69

451106 BE382701 Hs 25960 N-myc HLH.Myc.N.term 66

449433 AI672096 Hs 9012 ESTs 63

453922 AF053306 Hs 36708 budding uninhibited by benzimidazoles 1 (y 63

434636 AA083764 Hs 241334 ESTs 61

453688 AW381270 Hs 194110 Homo sapiens mRNA, cDNA DKFZp434C 59

422805 AA436989 Hs 121017 H2A histone family, member A histone 58

400292 AA250737 Hs 72472 BMPR-lb, bone morphogenetic protein rec 57

443179 AI928402 Hs 6933 Homo sapiens cDNA FLJ12684 fis, clone N 56

418134 AA397769 Hs 86617 ESTs 55

452249 BE394412 Hs 61252 ESTs homeobox 55

409269 AA576953 Hs 22972 Homo sapiens cDNA FU13352 fis, clone O TM.UPF0016 55

413335 AI613318 Hs 48442 ESTs 54

441081 AI584019 Hs 169006 ESTs, Moderately similar to plakophilm 2b PAX 54

428029 H05840 Hs 293071 ESTs 53

419183 U60669 Hs 89663 cytochrome P450, subfamily XXIV (vitami p450 53

409094 AW337237 gb xw82f01 x1 NCI_CGAP_Pan1 Homo sa 52

432938 T27013 Hs 3132 steroidogenic acute regulatory protein START 5 1

410102 AW248508 Hs 279727 ESTs, SS 5 1

447835 AW591623 Hs 164129 ESTs 5 1

438202 AW169287 Hs 22588 ESTs 50

423992 AW898292 Hs 137206 Homo sapiens mRNA, cDNA DKFZp564H 50

425905 AB032959 Hs 161700 KIAA1133 protein TM 50

452461 N78223 Hs 108106 transcription fxtor G9a,PHD 49

430691 C14187 Hs 103538 ESTs 48

441675 AI914329 Hs 5461 ESTs 47

425695 NM 005401 Hs 159238 protein tyrosine phosphatase, non-receptor Band_41 ,Y_phosphatase 46

440340 AW895503 Hs 125276 ESTs 45

428579 NM 005756 Hs 184942 G protein-coupled receptor 64 TM 45

444783 AK001468 Hs 62180 ESTs PH 44

451459 AI797515 Hs 270560 ESTs, Moderately similar to ALU7.HUMA 44

413395 AI266507 Hs 145689 ESTs 43

415263 AA948033 Hs 130853 ESTs histone 42

413988 M81883 Hs 75668 glutamate decarboxylase 1 (brain, 67kD) pyπdoxal.deC 42

452030 AL137578 Hs 27607 Homo sapiens mRNA, cDNA DKFZp564N 41

418852 BE537037 Hs 273294 hypothetical protein FU20069 41

446431 R45652 Hs 153486 ESTs 41

434891 AA814309 Hs 123583 ESTs 40

415139 AW975942 Hs 48524 ESTs G-patch 40

453197 AI916269 Hs 109057 ESTs, Weakly similar to ALU5 HUMAN A 40

447112 H17800 Hs 7154 ESTs 39

420633 NM 014581 Hs 99526 odorant-binding protein 2B TM.Iipocalin 39

459574 AI741122 Hs 101810 Homo sapiens cDNA FLJ14232 fis, clone N 39

415138 C18356 Hs 78045 tissue fxtor pathway Inhibitor 2 TFPI2 Kuπιtz_BPTI,G-gamma 39

414083 AL121282 Hs 257786 ESTs 37

442006 AW975183 Hs 292663 ESTs 37

409731 AA125985 Hs 56145 thymosiπ, beta, identified in neurobtastoma Thymosm 37

424906 AI566086 Hs 153716 Homo sapiens mRNA for Hmob33 protein, 37

456662 NM 002448 Hs 1494 msh (Drosophila) homeo box homolog 1 (to homeobox 37

429125 AA446854 Hs 271004 ESTs 36

435538 AB011540 Hs 4930 low density lipoprotein receptor-related pro 36

458861 AI630223 gb ad06g08 r1 Proliferating Erythroid Cells PHD 35

418506 AA084248 Hs 85339 G protein-coupled receptor 39 35

423123 NM.012247 Hs 124027 SELENOPHOSPHATE SYNTHETASE , H AIRS.AIRS 34

437960 AI669586 Hs 222194 ESTs 34

400298 AA032279 Hs 61635 STEAP1 TM 34

407162 N63855 Hs 142634 zinc finger protein 34

408621 AI970672 Hs 46638 chromosome 11 open reading frame 8, feta 33

445829 AI452457 Hs 145526 ESTs 33

450262 AW409872 Hs 271166 ESTs, Moderately similar to ALU7 HUMA 33

457979 AA776655 Hs 270942 ESTs TM 33

402606 #(NOCAT) 32

426471 M22440 Hs 170009 transforming growth fxtor, alpha SS.EGF 32 430294 AI538226 Hs.135184 ESTs polyprenyl.synt 3.2

448027 AI458437 Hs.177224 ESTs 3.2

432619 AW291722 Hs.278526 related to the N terminus of tre TBC 3.2

413627 BE182082 Hs.246973 ESTs 3.2

441377 BE218239 Hs.202656 ESTs 3.2

441085 AW136551 Hs.181245 Homo sapiens cDNA FU12532 fis, clone N 3.2

433527 AW235613 Hs.133020 ESTs 3.2

450171 AL133661 Hs.24583 hypothetical protein DKFZp434C0328 TM 3.2

419807 R77402 gb:yi75f11.s1 Soares plxenta Nb2HP Horn 3.1

418867 D31771 Hs.89404 msh (Drosophila) homeo box homolog 2 homeobox 3.1

419335 AW960146 Hs.284137 Homo sapiens cDNA FU12888 fis, clone N 3.1

450480 X82125 Hs.25040 zinc finger protein 239 zf-C2H2 3.1

420149 AA255920 Hs.88095 ESTs 3.1

413415 AA829282 Hs.34969 ESTs 3.1

438966 AW979074 gb:EST391184 MAGE resequences, MAGP 3.1

431041 AA490967 Hs.105276 ESTs Oxysterol.BP 3.1

415245 N59650 Hs.27252 ESTs 3.0

412140 AA219691 Hs.73625 RAB6 interxting, kinesin-like (rabkinesinδ kinesin 3.0

431707 R21326 Hs.267905 hypothetical protein FU 10422 3.0

448816 AB033052 Hs.22151 KIAA1226 protein 3.0

447866 AW444754 Hs.211517 ESTs homeobox 3.0

450221 AA328102 Hs.24641 cytoskeleton associated protein 2 3.0

406997 U07807 Hs.194762 Human metallothionein IV (MTIV) gene, c 3.0

433426 H69125 Hs.133525 ESTs ^' TM 3.0

420440 NM 002407 Hs.97644 mammaglobin 2 Uteroglobiπ 3.0

420181 AI380089 Hs.158951 ESTs 3.0

458627 AW088642 Hs.97984 ESTs; Weakly similar to WASP-family pro 2.9

452055 AI377431 Hs.293772 ESTs 2.9

429663 M68874 Hs.211587 Human phosphatidylcholine 2-acylhydrolas C2,PLA2_B 2.9

415125 AF061198 Hs.301941 Homo sapiens mRNA for norepinephrine tr TM.SNF 2.9

412708 R26830 Hs.106137 ESTs TM,7tm_2,Rho_GDI 2.9

451389 N73222 Hs.21738 KIAA1008 protein 2.9

423337 NM 004655 Hs.127337 axin 2 (coπductin, axil) DIX.RGS 2.9

435185 AA669490 Hs.289109 dimethylarginine dimethylaminohydrolase 2.9

428054 AI948688 Hs.266619 ESTs 2.9

448243 AW369771 Hs.77496 ESTs 2.9

425723 NM.014420 Hs.159311 dickkopf (Xenopus laevis) homolog 4 SS 2.9

432415 T16971 Hs.289014 ESTs 2.9

414747 U30872 Hs.77204 centromere protein F (350/400kD, mitosin) 2.9

400195 0 2.9

449874 AA135688 Hs.10083 ESTs 2.8

452367 U71207 Hs.29279 eyes absent (Drosophila) homolog 2 Hydrolase 2.8

428093 AW594506 Hs.104830 ESTs 2.8

409640 U78722 Hs.55481 zinc finger protein 165 TM,zf-C2H2,SCAN 2.8

424169 AA336399 Hs.153797 ESTs mito.carr 2.8

409638 AW450420 Hs.21335 ESTs 2.8

440048 AA897461 Hs.158469 ESTs, Weakly similar to envelope protein [ 2.8

426890 AA393167 Hs.41294 ESTs 2.8

452771 T05477 gb:EST03366 Fetal brain, Stratagene (cat93 2.8

422505 AU 20862 Hs.124165 ESTs; (HSAJPAP protein (programmed ce 2.8

416624 H69044 gb:yr77h05.s1 Soares fetal liver spleen 1 NF zf-C3HC4 2.8

445870 AW410053 Hs.13406 syntaxin 18 TM 2.7

441962 AW972542 Hs.289008 Homo sapiens cDNA: FU21814 fis, clone 2.7

447342 AI199268 Hs.19322 ESTs; Weakly similar to HI! ALU SUBFAM 2.7

421247 BE391727 Hs.102910 general transcription fxtor IIH, polypeptid 2.7

419752 AA249573 Hs.152618 ESTs 2.7

410658 AW105231 Hs.192035 ESTs 2.7

437698 R61837 Hs.7990 ESTs 2.7

458027 L49054 Hs.85195 ESTs, Highly similar to t(3;5)(q25.1 ;p34) f 2.7

438689 AW129261 Hs.250565 ESTs 2.7

439876 AI376278 Hs.100921 ESTs, Weakly similar to ALU7.HUMAN A SCAN 2.7

428479 Y00272 Hs.184572 cell division cycle 2, G1 to S and G2 to M pkinase 2.7

436406 AW105723 Hs.125346 ESTs 2.7

437938 AI950087 ESTs; Weakly similar to Gag-Pol polyprote 2.7

419917 AA320068 Hs.93701 Homo sapiens mRNA; cDNA DKFZp434E 2.7

434836 AA651629 Hs.118088 ESTs 2.7

448404 BE089973 gb:RC6-BT0709-310300-021-G07 BT0709 2.7

444078 BE246919 Hs.10290 U5 snRNP-spxific 40 kDa protein (hPrpB- WD40 2.7

409757 NM 001898 Hs.123114 cystatin SN SS.cystatin 2.6

443775 AF291664 Hs.204732 matrix metalloproteinase 26 TM,Peptidase_M10,7tm_1 2.6

427961 AW293165 Hs.143134 ESTs 2.6

426668 AW136934 Hs.97162 ESTs ^' 2.6

424717 H03754 Hs.152213 wingless-type MMTV integration site fami wnt 2.6

434669 AF151534 Hs.92023 core histone mxroH2A2.2 histone,A1pp,DUF27 2.6

417389 BE260964 Hs.82045 Midkine (neurite growth-promoting fxtor 2 SS,TM,PTN_MK 2.6

451009 AA013140 Hs.115707 ESTs 2.6

429774 AI522215 Hs.50883 ESTs pkinase 2.6

439951 AI347067 Hs.124636 ESTs TM 2.6

417576 AA339449 Hs.82285 phosphoribosylglycinamide formylfransfera AIRS.formyLtransf 2.5

416806 NM_0002BE I Hs.79993 peroxisomal biogenesis fxtor 7 WD40 2.5

420900 AL045633 Hs.44269 ESTs Ald_Xan_dh_C 2.5

457030 AI301740 Hs.173381 dihydropyrimidinase-like 2 Dihydroorotase 2.5

459583 AI907673 gb:IL-BT152-080399-004 BT152 Homo sa 2.5

440870 AI687284 Hs.150539 . Homo sapiens cDNA FU 13793 fis, clone T PAX, 2.5 446693 AW750373 Hs 42315 Homo sapiens cDNA FU 13036 fis, clone N TM 25 407289 AA135159 Hs 203349 Homo sapiens cDNA FU12149 fis, clone M 25 400882 0 25

431322 AW970622 gb EST382704 MAGE resequences, MAGK 25 424081 NM 006413 Hs 139120 πbonuclease P (30kD) 25 451996 AW514021 Hs 245510 ESTs 25

403381 #(NOCAT) 0 25 419488 AA316241 Hs 90691 nucleophosmin/nucleoplasmin 3 SS 25 418882 NM 004996 Hs 89433 ATP-binding cassette, sub-family C (CFTR TM.ABC.membrane 25

TABLE 17B

Pkey Unique Eos probeset identifier number CAT number Gene cluster number Accession Genbank xcession numbers

Pkey CAT Numbi Accession

409094 1099611 1 AW337237 AW861642 AW861655 AW858008 AW857990 AW858007

416624 1604694 1 H69044 T47567 H75691 T50292

419807 188252.1 R77402 AA262462 AA250988 R06794

431322 331543 1 AW970622 AA503009 AA502998 AA502989 AA502805 T92188

437938 44573 2 AI950087 N70208 R97040 N36809 AI308119 AW967677 N35320 AI251473 H59397 AW971573 R97278 W01059 AW967671 AA908598 AA251875

AI820501 AI820532 W87891 T85904 U71456 T82391 BE328571 T75102 R34725 AA884922 BE328517 AI219788 AA884444 N92578 F13493

AA927794 AI560251 AW874068 AL134043 AW235363 AA663345 AW008282 AA488964 AA283144 A1890387 AI950344 A1741346 A1689062

AA282915 AW102898 AI872193 AI763273 AW173586 AW150329 AI653832 AI762688 AA988777 AA488892 AI356394 AW103813 AI539642

AA642789 AA856975 AW505512 AI961530 AW629970 BE612881 AW276997 AW513601 AW512843 AA044209 AW856538 AA180009 AA337499

AW961101 AA251669 AA251874 AI819225 AW205862 AI683338 AI858509 AW276905 AI633006 AA972584 AA908741 AW072629 AW513996

AA293273 AA969759 N75628 N22388 H84729 H60052 T92487 AI022058 AA780419 AA551005 W80701 AW613456 AI373032 AI564269 F00531

H83488 W37181 W78802 R66056 AI002839 R67840 AA300207 AW959581 T63226 F04005

438966 467436 1 AW979074AA834841 AA828650

438993 467651 1 AA828995 AA834879 AI926361

442438 542469 1 AA995998 AI916584 R61781 T77332 F07756 F08149 F07647

448404 761515 1 BE089973 AI498612 AW805032

449034 794817 1 AI624049 AW117770 AI858360

452771 930983 1 T05477T07855 AI917711

458861 798085 1 AI630223 A1630470

TABLE 17C

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham I et al " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495

Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons

Pkey Ref Strand Nt position

400882 2842777 Minus 110431-110708

402606 9909429 Minus 81747-82094

403381 9438267 Minus 26009-26178 Table 18 lists lists 178 genes up-regulated in ovanan cancer compared to normal adult tissues that are likely to encode proteins that are secreted into blood, lymph, or other bodily fluids These genes, and/or their protein products, in combination or alone, are ideal candidates for the early diagnosis of ovanan cancer These were selected from 59680 probesets on the Affymetπx/Eos Hu03 GeneChip array such that the ratio of "average* ovarian cancer to "average" normal adult tissues was greater than or equal to 24, and that are likely to encode secreted or extracellularly-shed proteins The "average" ovanan cancer level was set to the 90th percentile amongst various ovarian cancer samples The "average" normal adult tissue level was set to the 90th percenlle amongst vaπous non-malignant tissues In order to remove gene-specific bxkground levels of non-specific hybπdizatioπ, the 15th percentile value amongst vaπous 149 non malignant tissues was subfrxted from both the numerator and the denominator before the ratio was evaluated

TABLE 18 ABOUT 178 UP-REGULATED GENES ENCODING SECRETED PROTEINS, OVARIAN CANCER VERSUS NORMAL ADULT TISSUES

Pkey Pπmekey

Ex Accn Exemplar Accession

UG ID UniGeπe lD

Title UmGene title ratio ratio tumor vs normal tissues

Pkey Ex Accn UG ID Title ratio

428579 NM.005756 Hs 184942 G protein-coupled receptor 64 305

436982 AB018305 Hs 5378 spondin 1, (f-spondin) extrxellularmat 294

427585 D31152 Hs 179729 collagen, type X, alpha 1 (Schmid metaph 270

423739 AA398155 Hs 97600 ESTs 227

418007 M13509 Hs 83169 Matπx metalloprotease 1 (interstitial c 206

438993 M73780 Hs 52620 integπn, beta 8 167

428664 AK001666 Hs 189095 similarto SALL1 (sal (Drosophila) like 165

439820 AL360204 Hs 283853 Homo sapiens mRNA full length insert cDN 165

400289 X07820 Hs 2258 Matrix Metalloprote ase 10 (Stromolysin 162

421155 H87879 Hs 102267 lysyl oxidase 16 1

431989 AW972870 Hs 291069 ESTs 159

426635 BE395109 Hs 129327 ESTs 159

424581 M62062 Hs 150917 catenin (cadheπn-associated protein), a 157

428976 AL037824 Hs 194695 ras homolog gene family, member I 151

416209 AA236776 Hs 79078 MAD2 (mitotic arrest deficient, yeast, h 150

439706 AW872527 Hs 59761 ESTs 147

452055 AI377431 Hs 293772 ESTs 132

410102 AW248508 Hs 279727 ESTs, 125

428392 H10233 Hs 2265 secretory granule, neuroendocπne protei 124 402606 AA434329 Hs 36563 hypothetical protein FU22418 11 5

443715 AI583187 Hs 9700 cyclin E1 107

433496 AF064254 Hs 49765 VLCS-H1 protein 106

418601 AA279490 Hs 86368 calmegm 103

409269 AA576953 Hs 22972 Homo sapiens cDNA FU13352 fis, 101

445537 AJ245671 Hs 12844 EGF-like-domain, multiple 6 99

427344 NM 000869 Hs 2142 5-hydroxytryptamιne (serotonin) receptor 97

428479 Y00272 Hs 184572 cell division cycle 2, G1 to S and G2 to 97

429782 NM 005754 Hs 220689 Ras-GTPase-xtivating protein SH3-domaιn 95

412140 AA219691 Hs 73625 RAB6 interxtmg, kinesm like (rabkmes 94

407881 AW072003 Hs 40968 heparan sulfate (glucosamine) 3-O-sulfot 94

435509 AI458679 Hs 181915 ESTs 93

408908 BE296227 Hs 48915 seπne/threonme kinase 15 90

433764 AW753676 Hs 39982 ESTs 90

445413 AA151342 Hs 12677 CGI-147 protein 87

438078 AI016377 Hs 131693 ESTs 86

447342 AI199268 Hs 19322 ESTs, Weakly similar to «" ALU SUBFA 8 1

415138 C18356 Hs 78045 tissue fxtor pathway inhibitor 2 TFPI2 77

418478 U38945 Hs 1174 cycliπ-dependent kinase inhibitor 2A (me 75

426320 W47595 Hs 169300 transforming growth fxtor, beta 2 75

424001 W67883 Hs 137476 KIAA1051 protein 74

458861 NM 007358 Hs 31016 DNA-BINDING PROTEIN M96 73

425465 L18964 Hs 1904 protein kinase C, iota 72

425776 U25128 Hs 159499 parathyroid hormone receptor 2 71

424620 AA101043 Hs 151254 kallikrein 7 (chymotryptic, stratum com 70

409178 BE393948 Hs 50915 kallikrein 5 68

433159 AB035898 Hs 150587 kinesin-like protein 2 66

410530 M25809 Hs 64173 ESTs, Highly similar to VAB1 65

449048 Z45051 Hs 22920 similarto S68401 (cattle) glucose indue 65

422095 A1868872 Hs 288966 ceruloplasmin (ferroxidase) 64

425371 D49441 Hs 155981 mesothelin 64

448706 AW291095 Hs 21814 class II cytokine receptor ZCYTOR7 64

441081 AI584019 Hs 169006 ESTs, Moderately similar to plakophilm 64

447207 AA442233 Hs 17731 hypothetical protein FU12892 63

420440 NM 002407 Hs 97644 mammaglobin 2 62

457030 AI301740 Hs 173381 dihydropyπmidiπase like 2 62

415139 AW975942 Hs 48524 ESTs 61

440870 AI687284 Hs 150539 Homo sapiens cDNA FLJ13793 fis, clone TH 60

417866 AW067903 Hs 82772 "collagen, type XI, alpha 1" 60

437960 AI669586 Hs 222194 ESTs 60

410555 U92649 Hs 64311 a disintegπn and metalloproteinase doma 59

433447 U29195 Hs 3281 neuronal penfraxin II 59

437099 N77793 Hs 48659 ESTs, Highly similar to LMA1 59

427510 Z47542 Hs 179312 small nuclear RNA activating complex, po 59

422867 L32137 Hs 1584 cartilage oligomeric matrix protein 58

444478 W07318 Hs 240 M phase phosphoprotem 1 57

445640 AW969626 Hs 31704 ESTs, Weakly similar to KIAA0227 [H sapi 57

453775 NM.002916 Hs 35120 replication fxtor C (xtivator 1) 4 (37 56

419917 AA320068 Hs 93701 Homo sapiens mRNA, cDNA DKFZp434E232 56

424539 L02911 Hs 150402 xtivm A receptor, type I 55

441645 AI222279 Hs 201555 ESTs 55

424345 AK001380 Hs 145479 Homo sapiens cDNA FU10518 fis, clone NT 54

426514 BE616633 Hs 301122 bone morphogenetic protein 7 (osteogenic 54

425154 NM 001851 Hs 154850 collagen, type IX, alpha 1 54

416530 U62801 Hs 79361 kallikrein 6 (neurosm, zyme) 53

445236 AK001676 Hs 12457 hypothetical protein FLJ 10814 52

452930 AW195285 Hs 194097 ESTs 52

431130 NM 006103 Hs 2719 epididymts-specific, whey-xidic protein 5 1

411571 AA122393 Hs 70811 hypothetical protein FU20516 5 1

432158 W33165 Hs 55548 ESTs, Weakly similar to unknown protein 50

447020 T27308 Hs 16986 hypothetical protein FU11046 50

443268 AI800271 Hs 129445 hypothetical protein FU12496 49

448133 AA723157 Hs 73768 folate receptor 1 (adult) 49

418882 NM 004996 Hs 89433 ATP-binding cassette, sub-family C (CFTR 48

428555 NM.002214 Hs 184908 mtegππ, beta 8 48

427528 AU077143 Hs 179565 minichromosome maintenance deficient (S 47

406400 AA343629 Hs 104570 kallikrein 8 (neuropsin/ovasm) 47

439024 R96696 Hs 35598 ESTs 46

426300 U15979 Hs 169228 delta-like homolog (Drosophila) 46

448027 AI458437 Hs 177224 ESTs 46

404996 NM.001333 Hs 87417 Cathepsin L2 46

443933 AI091631 Hs 135501 ESTs 45

409459 D86407 Hs 54481 low density lipoprotein receptor-related 44

414747 U30872 Hs 77204 centromere protein F (350/400kD, mitosin 43

423123 NM.012247 ^' Hs 124027 SELENOPHOSPHATE SYNTHETASE 43

448275 BE514434 Hs 20830 synaptic Ras GTPase xtivating protein 1 42

419926 AW900992 Hs 93796 DKFZP586D2223 protein 41

420736 AI263022 Hs 82204 ESTs 41

419790 U79250 Hs 93201 glycerol-3-phosphate dehydrogenase 2 (mi 41

414343 AL036166 Hs 75914 coated vesicle membrane protein 40

450654 AJ245587 Hs 25275 Kruppel-type zinc finger protein 40

445808 AV655234 Hs 298083 ESTs 39

417389 BE260964 Hs 82045 Midkme (neunte growth promoting fxtor 39

425247 NM 00594C I Hs 155324 matπx metalloproteinase 11 (stromelysin 38 430634 AI860651 Hs.26685 ESTs 3.8

431846 BE019924 Hs.271580 Uroplakin 1B 3.7

416658 U03272 Hs.79432 fibriiliπ 2 (congenital contrxtural ara 3.7

407792 AI077715 Hs.39384 putative secreted ligand homologous to f 3.7

420585 AW505139 Hs.279844 hypothetical protein FU 10033 3.7

407756 AA116021 Hs.38260 ubiquitin specific protease 18 3.6

411773 NM 006799 Hs.72026 protease, serine, 21 (testisin) 3.6

421928 AF013758 Hs.109643 polyadenylate binding proteiπ-interxtiπ 3.5

431958 X63629 Hs.2877 Cadherin 3, P-cadherin (plxeπtal) 3.5

410467 AF102546 Hs.63931 dxhshund (Drosophila) homolog 3.5

418793 AW382987 Hs.88474 prostaglandin-endoperaxide synthase 1 (p 3.5

422278 AF072873 Hs.114218 ESTs 3.5

431840 AA534908 Hs.2860 POU domain, class 5, transcription fxto 3.4

408730 AV660717 Hs.47144 DKFZP586N0819 protein 3.4

419452 U33635 Hs.90572 PTK7 protein tyrosine kinase 7 3.3

421841 AA908197 Hs.108850 KIAA0936 protein 3.3

439864 AI720078 Hs.291997 ESTs 3.3

456546 AI690321 Hs.203845 ESTs, Weakly similar to TWIK-related xi 3.2

410687 U24389 Hs.65436 lysyl oxidase-like 1 3.2

414774 X02419 Hs.77274 plasmiπogen xtivator, urokinase 3.2

420552 AK000492 Hs.98806 hypothetical protein 3.1

421991 NM 014918 Hs.110488 KIAA0990 protein 3.1

418140 BE613836 Hs.83551 microfibrillar-associated protein 2 3.1

458924 BE242158 Hs.24427 DKFZP5660Ϊ646 protein 3.1

411789 AF245505 Hs.72157 Homo sapiens^mRNA; cDNA DKFZp564H9 3.1

434241 AF119913 Hs.283607 hypothetical protein PRO3077 3.1

422611 AA158177 Hs.118722 fύcosyllransferase 8 (alpha (1,6) fucosy 3.1

409533 AW969543 Hs.21291 itogen-xtivated protein kinase kinase 3.1

416391 AI878927 Hs.79284 mesoderm specific transcript (mouse) horn 3.1

412604 AW978324 Hs.47144 DKFZP586N0819proieiπ 3.1

425851 NM 001490 Hs.159642 glucosaminyl (N-xetyl) fransferase 1, c 3.0

431259 NM 006580 Hs.251391 daudin 16 3.0

418557 BE140602 Hs.246645 ESTs 3.0

428242 H55709 Hs.2250 leukemia inhibitory fxtor (cholinergic 3.0

419359 AL043202 Hs.90073 chromosome segregation 1 (yeast homolog) 3.0

457590 AI612809 Hs.5378 spondin 1, (f-spondin) extracellular mat 2.9

419741 NM 007019 Hs.93002 ubiquitin carrier protein E2-C 2.9

428330 L22524 Hs.2256 matrix metalloproteinase 7 (matrilysin, 2.9

417315 AI080042 Hs.180450 ribosomal protein S24 2.9

438777 AA825487 Hs.142179 ESTs, Weakly similar to ORF2 [M.musculus 2.9

442295 AI827248 Hs.224398 ESTs 2.9

428248 AI126772 Hs.40479 ESTs 2.9

403019 AA834626 Hs.66718 RAD54 (S.cerevisiae)-like 2.8

436252 AI539519 Hs.120969 Homo sapiens cDNA FU11562 fis 2.8

419488 AA316241 Hs.90691 nucleophosmiπ/nucleoplasmin 3 2.8

434288 AW189075 Hs.116265 ESTs 2.7

407872 AB039723 Hs.40735 frizzled (Drosophila) homolog 3 2.7

431611 U58766 Hs.264428 tissue specific transplantation antigen 2.7

443881 R64512 Hs.237146 Homo sapiens cDNA FLJ14234 fis, clone NT 2.7

453779 N35187 Hs.43388 ESTs 2.7

433068 NM 06456 Hs.288215 sialyltransferase 2.7

426841 AI052358 Hs.193726 ESTs 2.7

428778 AK000530 Hs.193326 fibroblast growth fxtor receptor-like 1 2.7

451346 NM.006338 Hs.26312 glioma amplified on chromosome 1 protein 2.6

443883 AA114212 Hs.9930 serine (or cysteine) prateinase inhibito 2.6

420162 BE378432 Hs.95577 cyclin-dependent kinase 4 2.6

447149 BE299857 Hs.326 TAR (HIV) RNA-binding protein 2 2.6

433656 AW974941 Hs.292385 ESTs 2.6

408210 N81189 Hs.43104 ESTs 2.6

430651 AA961694 Hs.105187 kinesin protein 9 gene 2.5

422599 BE387202 Hs.118638 non-metastatic cells 1, protein (NM23A) 2.5

421802 BE261458 Hs.108408 CGI-78 protein 2.5

446211 AI021993 Hs.14331 S100 calcium-binding protein A13 2.5

404029 W72881 Hs.266470 protocadherin beta 2 2.5

453012 T95804 Hs.31334 putative mitochondrial outer membrane pr 2.5

419981 AA897581 Hs.128773 ESTs 2.5

448153 Y10805 Hs.20521 HMT1 (hnRNP methyltransferase, S. cerevi 2.5

419220 AA811938 Hs.291759 ESTs 2.5

432180 Y18418 Hs.272822 RuvB (E coli homo!og)-like 1 2.4

406850 AI624300 Hs.172928 collagen, type 1, alpha 1 2.4

409893 AW247090 Hs.57101 minichromosome maintenance deficient (S. 2.4

421654 AW163267 Hs.106469 suppressor of varl (S.cerevisiae) 3-like 2.4

409956 AW103364 Hs.727 H.sapiens xtivin beta-A subunit (exon 2 2.4

407584 W25945 Hs.18745 ESTs 2.4

448796 AA147829 Hs.33193 ESTs, Highly similar to AC0072283 BC372 2.4

Table 19 lists about 17 genes up-regulated in ovarian cancer compared to noπnal adult tissues that are likely to encode proteins that are secreted into blood, lymph, or other bodily fluids. These genes, and/or their protein products, in combination or alone, are ideal candidates for the early diagnosis of ovarian cancer. These were selxted from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the ratio of "average" ovarian cancer to "average" normal adult tissues was greater than or equal to 2.4, and that are likely to encode secreted or extracellulariy-shed proteins. The "average" ovarian cancer level was set to the 90th percentile amongst various ovarian cancer samples. The "average" normal adult tissue level was set to the 90th percentile amongst various non-malignant tissues. In order to remove gene-specific bxkground levels of non-specific hybridization, the 15th percentile value amongst various non-malignant tissues was subtrxted from both the numerator and the denominator before the ratio was evaluated. TABLE 19 ABOUT 17 GENES, AND COMBINATIONS THEREOF, USEFUL FOR DIAGNOSIS OF OVARIAN CANCER

UG ID UniGene ID

Title UniGene Title

% tumors percent of tumors detected expressing gene

Single genes

UG ID Title % tumors

Hs 5378 spondin 1, (f-spondin) extrxellular matnx protein 77 Hs 12844 EGF-like-domam 6 86

Hs 151254 kallikrein 7 (chymotryptic, stratum comeum) 66

Hs 97644 mammaglobin 2 73

Hs 155981 mesothelm (cytokine) 57

Hs 2258 Matπx Metalloprotemase 10 (Stromolysin 2) 21 Hs 50915 kallikrein 5 27

Hs 301122 bone morphogenetic protein 7 (osteogenic protein 1) (BMP7) 54

Hs 79361 kallikrein 6 (neurosin, zyme) 38

Hs 83169 MMP 1 (interstitial collagenase) 23

Hs 72026 protease, seπne, 21 (testisin) 16 Hs 39384 putative secreted ligand homologous to fjxl 46

Hs 2719 epididy is specific, whey-acidic protein type, four-disulfide core 91

Hs 155324 matπx metalloproteinase 11 (stromelysin 3) 11

Hs 1584 cartilage oligomeπc matπx protein 25

Hs 169300 TGF beta 2 21 Hs 2250 leukemia inhibitory fxtor (oholmergic differentiation factor) 23

Exemplary Combinations

EGF-like-domam 6 + mammaglobin 2 93 kallikrein 7 + mesothelm 71 mammaglobin 2 + bone morphogeπic protein 7

EGF-like-domam 6 + bone morphogenic protein 7 91 kallikrein 7 + bone morphogenic protein 7 + testisin 75 kallikrein 7 + mammaglobin 2 + mesothelm 84 mammaglobin 2 + bone morphogenic protein 7 + TGF beta 2 91 EGF-like-domam 6 + bone morphogenic protein 7 + MMP 1 95

Table 20A lists about 1025 genes up-regulated in ovanan cancer compared to nomial adult tissues Genes associated with ovarian cancer were selected from the 53462 probesets such that the ratio of "average" ovanan cancer to "average" normal adult tissues was greater than or equal to 50 The "average" ovarian cancer level was set to the 93rd percentile value amongst vanous ovarian cancer specimens, the "average" normal adult tissue level was set to the 96th percentile value amongst various non-malignant tissues In order to remove gene specific bxkground levels of non-specific hybridization, the 15th percentile value amongst vaπous non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated

Tables 20B-24B list xcession numbers for Pkey's Ixking UnigenelD's for tables 20A-24A For each probeset is listed a gene cluster number from which oligonucleotides were designed Gene clusters were compiled using sequences deπved from Genbank ESTs and mRNAs These sequences were clustered based on sequence similarity using Clusteπng and Alignment Tools (DoubleTwist, Oakland California) Genbank xcession numbers for sequences compns g each cluster are listed in the "Accession" column

Tables 20C-24C list genomic positioning for Pkey's lacking Unigene ID's and xcession numbers in tables 20A-24A For each predicted exon is listed genomic sequence source used for prediction Nucleotide locations of exh predicted exon are also listed

TABLE 20A

Pkey Unique Eos probeset identifier number

ExAccn Exemplar Accession number, Genbank xcession number

UmgenelD Unigene number

Unigene Title UniGene title

Pred Protein Dom Predicted protein domain

R1 Ratio of tumor to normal body tissue

Pkey ExAccn UniGene ID Unigene Title Pred Protein Dom R1

421296 NM 002666 Hs 103253 penlφin peπlipin.SS 325

453028 AB006532 Hs 31442 RecQ protein-like 4 DEAD,helιcase_C,Fork_head 276

422310 AA316622 Hs 98370 cytochrome P450, subfamily IIS SS,TM,pkmase,frι3,ιg 265

437897 AA770561 Hs 146170 hypothetical protein FU22969 SS,TM,zf-DHHC 263

446374 AA329256 Hs 24756 ESTs, Moderately similar to al 226

441021 AW578716 Hs 7644 H1 histone family, member 2 223

409518 BE384836 Hs 3454 KIAA1821 protein SS 21 3

413436 AF238083 Hs 68061 sphingosme kinase 1 DAGKc 21 2

424420 BE614743 Hs 146688 prostaglandin E synthase MAPEG,SS,TM,MAPEG 207

422645 L40027 Hs 118890 glycogen synthase kinase 3 alp pkinase SS.Ets 207

422098 H03117 Hs 111497 similar to mouse neuronal prot TM 202

429556 AW139399 Hs 98988 ESTs SS.pkinase PMP22_Claudιn 20 1

436485 X59135 Hs 156110 immunoglobulin kappa constant SS,ιg,SS 199

423652 AF052122 Hs 130712 Homo sapiens clone 23929 mRNA ABC1,SS,PID,PID 198

431773 BE409442 Hs 268557 plxkstπn homology-like domai PH.SS LIM roponin 194

422179 AF091619 Hs 112667 dyne , axoπemal, intermediate WD40.SS 193

420839 AI792682 Hs 282960 hypothetical protein MGC10870 SS,DS,UPF0139,Glyco_hydro 185

441356 BE384361 Hs 182885 ESTs, Weakly similar to JC5024 SS,TM,ank 185

424659 AW891298 Hs 331601 Homo sapiens, Similar to cyste SS.Fork head 184

439924 AI985897 Hs 125293 ESTs SS 18 1

458814 AI498957 Hs 170861 ESTs, Weakly similar to Z195.H SS.TM.Idl recepLa,ldl_re 175

451643 M64437 Hs 234799 breakpoint cluster region RhoGEF,RhoGAP,PH,C2 172

439108 AW163034 Hs 6467 synaptogyππ 3 Syπaptogyπn,SS,TM,PDZ,WD 169

432945 AL043683 hypothetical protein FU10803 SS 168 410418 D31382 Hs 63325 transmembrane protease, seπne SS,TM,ldl recept a frypsi 168

438424 AI912498 Hs 25895 hypothetical protein FU14996 SS M 167

409435 AI810721 Hs 95424 ESTs SS 164

418969 W33191 Hs 28907 hypothetical protein FLJ20258 SH3.SH3 162

421612 AF161254 Hs 106196 8D6 antigen Idl recept a.SSJM 160

456177 NM.012391 Hs 79414 prostate epithelium-spxific E Ets,SAM_PNT 157

414837 U24266 Hs 77448 aldehyde dehydrogenase 4 famil aldedh 156

432631 H08379 Hs 165563 hypothetical protein DKFZp434N TM,DnaJ,UBA,ArfGap,homeob 155

454017 AW023617 Hs 347130 hypothetical protein FU22709 SS M.myosin head RA.DAG 155

401278 Target Exon Band 41 154

444804 A1084452 Hs 22158 hypothetical protein FU21988 SS 154

410259 AK000337 Hs 61485 hypothetical protein GFO_IDH_MocA,GFO_IDH_MocA 154

406620 M81105 Hs 146550 myosin, heavy polypeptide 9, n myosin head,Myosιn_taιl,l 151

423081 AF262992 Hs 123159 sperm associated antigen 4 TM 149

421495 AI583067 Hs 149152 ESTs, Weakly similar to RHOP M 147

416893 AA455588 Hs 62406 hypothetical protein FU22573 SS.rrm.SS 147

413244 AW955951 Hs 159265 kruppel-related zinc finger pr SS,TM,BTB,Pep_M12B_propep 146

406901 M14624 gb Human 4-beta-galxtosyltraπ 146

416006 AA324251 Hs 78950 branched chain keto xid dehyd E1 dehydrog 146

436186 BE390717 Hs 5074 similar to S pombe iml DIM1.SS 145

455557 AW995839 gb QV4-BN0044-110200-108-h07 B Metallophos 144

434518 H56995 Hs 37372 Homo sapiens DNA binding pepti SS 142

421489 AI922821 Hs 32433 ESTs SS,PI-PLC-X,PI PLC-Y.C2 141

444441 AW613841 Hs 301394 hypothetical protein MGC3101 140

435017 AA336522 Hs 12854 angiotensin II, jype 1 recepto 140

446572 AV659151 Hs 282961 ESTs 139

434068 AA977935 Hs 127274 ESTs SS 137

432481 AW451645 Hs 151504 Homo sapiens cDNA FU11973 fis SS,CoIlagen,COLFI,TSPN 137

447304 Z98883 Hs 18079 phosphatidylmositol glycan, c SS,Peptιdase_C2 136

421182 AA284855 Hs 104480 ESTs SS.Topoisomerase I.Topois 133

407767 W15398 Hs 38628 hypothetical protein SS,zf-CCCH 13 3

456642 AW451623 Hs 109752 putative c-Myc-responsive 133

437457 AA757900 Hs 270823 ESTs, Weakly similar to S65657 SQS PSY 132

430178 AW449612 Hs 152475 ESTs SS 13 1

430399 AI916284 Hs 199671 ESTs Sec7,PH 129

436725 BE045223 Hs 136912 hypothetical protein MGC10796 129

410219 T98226 Hs 171952 occludin SS,TM,Occludιn,BIR 127

442620 C00138 Hs 8535 Homo sapiens mRNA for KIAA1668 SS,RNA_pol K 127

439233 AA831893 Hs 292767 hypothetical protein FLJ23109 zf-C3HC4,TM,Sulfate trans 127

425018 BE245277 Hs 154196 E4F franscπption factor 1 zf C2H2,LIM,SS,Exo endo p 126

423801 NMJ15071 Hs 132942 GTPase regulator associated wi RhoGAP,SH3,PH 126

417826 T85105 Hs 15471 ESTs SS,cadheπn,Cadheπn_C_te 126

409261 BE315042 Hs 19210 hypothetical protein MGC11308 126

420568 F09247 Hs 247735 protocadheπn alpha 10 cadheπn,SS,TM,cadheπn 126

411570 BE144584 Hs 314341 ESTs 125

430397 AI924533 Hs 105607 bicarbonate transporter relate HC03 cotransp.SSJM 125

423767 H18283 Hs 132753 F-box only protein 2 F-box,SS,F-box,HORMA 124

441805 AA285136 Hs 301914 neuronal spxific transcπptio UM,SS,LIM 123

402365 Tarcjet Exon SS,SS,TM,ιg 122

414371 AI905865 thymosm, beta 4, X chromosome Thymosm 122

446780 R31107 gb yh61g01 s1 Soares plxenta 121

428782 X12830 Hs 193400 interleukiπ 6 receptor SS,TM,fπ3,ιg,SS,TM 121

427695 R88483 Hs 172862 intron of Bicaudal D homolog 1 121

400460 C11002253* gι|129091|spp23267 SS,TM,SCAN,zf-C2H2,KRAB 120

407341 AA918886 Hs 204918 ESTs, Weakly similar to ALU8 H SSJM 120

424049 AB014524 Hs 138380 KIAA0624 protein SS 11 9

422872 BE326786 Hs 187646 ESTs TM 11 9

450800 BE395161 Hs 1390 proteasome (prosome, macropain SS 11 8

428648 AF052728 Hs 188021 potassium voltage-gated channe cNMP.bindmg 11 7

432329 NM.0Q2962 Hs 2960 S100 calcium-binding protein A S 100,efhand,SS,efhand,S 117

417061 AI675944 Hs 188691 Homo sapiens cDNA FU12033 fis CTF.NFI 11 6

451195 U10492 Hs 438 mesenchyme homeo box 1 homeo box.SS 11 5

417595 AA424317 Hs 6259 KIAA1698 protein SS,TM,Glyco_hydro_31 ,Glyc 11 5

426500 NM 014638 Hs 170156 KIAA0450 gene product SS 11 4

433124 U51712 Hs 13775 hypothetical protein SMAP31 11 4

444001 AI095087 Hs 152299 ESTs, Moderately similar to S6 114

419298 AA853479 Hs 89890 pyruvate carboxylase CPSase L cham.PYC OADA.H 11 4

428593 AW207440 Hs 185973 degenerative spermatocyte (horn SS 11 3

411408 U76666 Hs 69949 calcium channel, voltage-depen lon.trans.SS.TM 11 2

404438 Target Exon 11 2

427448 BE246449 Hs 2157 Wiskott-Aldπch syndrome (ecze WH1,PBD,WH2,SS 11 2

406230 Target Exon 11 2

432125 AW972667 Hs 183006 Homo sapiens cDNA FLJ 12300 fis Band_41,ERM 11 2

408832 AW085690 Hs 63428 ESTs, Weakly similar to Z195.H 11 1

400206 Eos Control ^•SS.SS.GIyco franf_43,COLF 11 1

450503 R35917 Hs 301338 hypothetical protein FU12587 SS 11 0

407605 W03512 Hs 6479 hypothetical protein MGC13272 SS,Sema,pkιnase,TIG,PSI,e 11 0

432143 AL040183 Hs 123484 Homo sapiens, clone IMAGE 4178 SS,TM,cys_πch_FGFR 109

446839 BE091926 Hs 16244 mitotic spindle coiled-coil re Troponιn,SS,glycolytιc en 108

443559 AI076765 Hs 269899 ESTs, Moderately similar to AL SS,TM,BIR,UQ_con 108

411298 AW835858 gb PM0-LT0017-031299-001-h07 L 108

409557 BE182896 Hs 211193 ESTs 108

435158 AW663317 Hs 65588 DAZ associated protein 1 rrm.SS.rrm 108

444410 BE387360 Hs 33719 ESTs, Moderately similar to S6 SS 106 428948 BE514362 FK506-bιndιng protein 3 (25kD) FKBP.PIP5K 106

424707 BE061914 Hs 10844 Homo sapiens cDNA FU14476 fis SS,SS,TM,Sema 106

416819 U77735 Hs 80205 pιm-2 oncogene pkιnase,SS,TM,OTU,K tetra 105

419341 N71463 Hs 118888 ESTs, Weakly similar to ALU1.H SS,TM,UPF0016 105

444359 AI697160 Hs 143594 ESTs, Weakly similar to HS4L.H 105

404333 C7001735* gι|7768636|dbj|BAA95 vwd 105

401210 C12000519 gι|7710046|ref|NP_05 105

457941 AI004525 Hs 14587 ESTs, Weakly similar to AF1518 SS,TM,SS,TM 104

401594 NM.024817 Homo sapiens hypothe 103

441790 AW294909 Hs 132208 ESTs 103

444008 BE544855 Hs 236572 ESTs, Weakly similar to SFR4 H SS.SS.SAC3 GANP 103

438185 Y19188 Hs 320461 ESTs SS 102

432031 AF039196 Hs 272367 hairless protein (putative sin jmjC 102

410471 T88872 gb yd31a12 s1 Soares fetal liv 10 1

433573 AF234887 Hs 57652 cadheπn, EGF LAG seven-pass G SS,TM,7tm_2,EGF,cadheπn, 10 1

417371 N74613 Hs 269149 ESTs 100

428167 AA770021 Hs 16332 ESTs SS,ιg,fn3 100

419563 AA526235 Hs 193162 Homo sapiens cDNA FU11983 fis 100

412674 X04106 Hs 74451 calpain 4, small subunit (30K) efhand.SS.CAP.GLY 100

425863 U43604 Hs 159901 Human unidentified mRNA, parti 99

442739 NM 007274 Hs 8679 cytosolic xyl coenzyme A thio Acyl-CoA_hydro,SS,TM 99

429469 M64590 Hs 27 giycine dehydrogenase (dxarbo GDC-P.GDC-P 99

420029 BE258876 Hs 94446 polyamine modulated fxtor 1 aldo keLred,SS,TM,gla 98

445625 BE246743 hypothetical protein FU22635 SSJM

435339 AI358300 ESTs SS.ras 98

407235 D20569 Hs 169407 SAC2 (suppressor of xtin muta SSJM.Ribosomat S13,Galac 98

428758 AA433988 Hs 98502 CA125 antigen, muciπ lδ SS 98

401349 mositol polyphosphate-1-phosp 97

437915 AI637993 Hs 202312 Homo sapiens clone N11 NTera2D 97

424511 BE300512 Hs 193557 ESTs, Moderately similar to AL 97

423366 Z80345 Hs 127610 xyl-Coenzyme A dehydrogenase, Acyl CoA dh,Acyl-CoA_dh M 97

405143 NM 013432* Homo sapiens nuclea ank,SS,TM,CPSF_A 96

427497 AW139476 Hs 31240 ESTs 96

420423 AA827718 Hs 88218 ESTs SS 96

431512 BE270734 Hs 2795 lactate dehydrogenase A Idhjdh CSSJdh 96

450052 AI681298 Hs 236524 ESTs zf C3HC4,zf-B_box 95

412738 N34731 Hs 74562 siah binding protein 1, FBP in homeobox 95

444202 AL031685 Hs 12785 KIAA0939 protein SS,TM,Na_H_Exchaπger,ABC2 95

451165 AI340575 Hs 286084 MRIP-1 protein 95

411450 H49619 Hs 127301 ESTs SS.pkinase 95

405371 NM.005569* Homo sapiens UM do pkιπase,LIM,PDZ 95

435782 N49433 Hs 285737 Homo sapiens cDNA FU20895fi SS,G6PD,Glucosamιne_ιso,G 95

416866 AA297356 Hs 80324 seπne/threonme protein phosp Metallophos Metallophos 94

405474 NM.001093* Homo sapiens acetyl CPSase_L_chaιn,bιotιn_lιp 94

412837 AI922293 Hs 58389 hypothetical protein MGC4090 93

448133 AA723157 Hs 73769 folate receptor 1 (adult) Folate rec.SS 93

431081 AA491594 Hs 75813 polycystic kidney disease 1 (a SSJM 93

427640 AF058293 Hs 180015 D-dopxhrome tautomerase MIFJate protein L2,SS,GS 92

427435 AW938739 Hs 115412 hypothetical protein FU13881 SS 92

407688 W25317 Hs 37616 Human D9 splice vaπant B mRNA 92

407507 U73799 gb Human dynxtm mRNA, partia SSJM.HC03 cotransp.CAP G 92

400833 C11000890 gι|3746443|gb|AAC639 SS,TM,7tm 1 92

422064 AW452589 Hs 335742 ESTs TM 92

452434 D30934 Hs 29549 C-type lectin like receptor-1 lxtιn_c,SS,TM 92

451752 AB032997 KIAA1171 protein TBC,SS,TM,pkιnase,lamtnιn 92

432931 AF174487 Hs 293753 Bcl-2-related ovanan killer p 91

407893 BE408359 Hs 43621 Homo sapiens, Similar to hypot SS,SS,arf,ras,fn3,ras 91

427397 AI929685 Hs 177656 calmodulin 1 (phosphorylase ki efhand,RmaAD,SS,efhand 91

405159 ENSP00000243337* CDNA FLJ13984 91

422283 AW411307 Hs 114311 CDC45 (cell division cycle 45, CDC45 91

407058 X94563 gb H sapiens dbi/acbp gene exo SS 90

448045 AJ297436 Hs 20166 prostate stem cell antigen SS,TM,UPAR_LY6,toxιn,SS,T 90

400772 NM.003105* Homo sapiens sortil Idl recepLa,fn3,ldl rece 90

427315 AA179949 Hs 175563 Homo sapiens mRNA, cDNA DKFZpδ spectπn,SH3,PH,CH 90

414391 BE409872 gb 601299655F1 NIH MGC 21 Homo 90

447867 AI525268 Hs 164303 ESTs TM 90

422639 AI929377 Hs 173724 creatine kinase, brain ATP-gua Ptrans,ATP-gua Pt 90

454319 AW247736 Hs 101617 ESTs, Weakly similar to T32527 SS 89

428781 AF164799 Hs 193384 putatative 28 kDa protein 89

408645 AW245738 Hs 109274 hypothetical protein MGC4365 SSJM 89

429527 AA454184 Hs 289014 ESTs 89

406651 AI559224 gb tq32c02x1 NCI CGAP Ut1 Horn 89

430893 BE502068 Hs 282067 ESTs

414413 BE294877 gb 601174162F1 NIH.MGC.17 Homo SS

413726 AJ278465 Hs 75510 aπnexιn A11 annexιπ,SS,annexιn

432211 BE274530 Hs 273333 hypothetical protein FU 10986

421694 BE387430 Hs 106880 bystm-like

453683 AL079854 Hs 118598 Homo sapiens mRNA for KIAA1878 SS

456741 W37608 Hs 184492 ESTs SS.pkinase 87

442995 AA532511 Hs 288455 Homo sapiens cDNA FU23270 fi 87

415898 Z43379 Hs 177193 gb HSC1AE111 normalized infant 87

456977 AK000252 Hs 169758 hypothetical protein FLJ20245 87

439632 AW410714 Hs 334437 hypothetical protein MGC4248 SS,TM,fransmembrane4 87

431462 AW583672 Hs 256311 granm like neuroendocππe pep SS 87 400128 Eos Control TM,E1-E2_ATPase,HMA,Hydro 87

438582 AI521310 Hs 283365 ESTs, Weakly similar to ALU5.H SS 87

450958 AL137669 Hs 348012 Homo sapiens mRNA, cDNA DKFZp4 87

410855 X97795 Hs 66718 RAD54 (S cerevιsιae)-lιke SNF2_N,helιcase C,SS 87

415126 D60945 gb HUM141D04B Cloπtech human f SSJM 87

418736 T18979 Hs 87908 Snf2-related CBP xtivator pro SS.helicase CAT hook.SS, 86

431157 AI823969 Hs 132678 ESTs SS,MAPEG,SS,MAPEG 86

418843 AJ251016 Hs 89230 potassium intermediate/small c TM,CaMBD,SK chanπel.TM 86

419167 AI589535 Hs 94875 ESTs, Weakly similar to A35363 SS 86

432343 NM.002960 Hs 2961 S100 calcium binding protein A S_100,SS,efhand,S_100,efh 86

458440 AI09546B Hs 135254 Homo sapiens clone 1 thrombosp 86

407065 Y10141 gb H sapiens DAT1 gene, partia SNF.SSJM 86

452851 AW173191 Hs 213117 ESTs SS.Sema 86

422418 AK001383 Hs 116385 hypothetical protein FU10521 RhoGEF 86

420836 AW958453 Hs 204959 hypothetical protein FU 14886 SS.ras 86

455588 AI129803 Hs 74669 vesicle-associated membrane pr syπaptobrevm.SSJM 85

431974 AW972689 Hs 200934 ESTs bZIP 85

410720 AF035154 Hs 65756 regulator of G-protein sigπall RGS,G-gamma,DEP,SS,RGS,DI 85

449751 AW207115 Hs 25555 ESTs 85

434030 AW162336 Hs 3709 low molecular mass ubiqumone- SS 85

405557 Target Exon Ets,SAM PNT 85

443780 NM 012068 Hs 9754 xtivating transcπption facto bZIP.NTP transf 2.SSJBC 85

428860 U38291 Hs 194301 microtubule-associated protein M 85

421901 AB014554 Hs 109299 protein tyrosine phosphatase, SAM,SS,TM,rrm,PDZ 84

401885 Target Exon * kinesin.SS.TM 84

449382 AI650407 Hs 197875 ESTs SS,rrm,zf-RanBP 84

432862 AW004958 Hs 236720 am onless protein SS,MATH,zf-TRAF,zf-C3HC4 84

441363 AW450211 Hs 126825 ESTs, Weakly similar to A46302 SS,TM,HSP20,7tm_1 84

407363 AF035032 Hs 181125 gb Homo sapiens clone MCA1L my SS,ιg,SS,G_glu transpept 84

425380 AA356389 Hs 32148 AD-015 protein SS ,TM,LRR P.Peptidase S8 84

424893 AW295112 Hs 153648 Homo sapiens cDNA FU13303 fis SS,SAM,SS,TM,7tm_1 84

424080 AW189983 Hs 139119 Homo sapiens cDNA FU10967 fis 83

439772 AL365406 Hs 10268 Homo sapiens mRNA full length 83

431765 AF124249 Hs 268541 novel SH2-contaιnmg protein 1 SH2.SSJM 83

404365 Target Exon SS 83

424310 AA338648 Hs 50334 testes development-related NYD SSJM 83

401935 Target Exon PH 83

434796 AA812046 ESTs SS.myb.DNA binding.myb.DN 83

423098 AA321980 Hs 204682 ESTs 83

434552 AA639618 Hs 325116 Homo sapiens, clone MGC 2962, SS 82

457082 AA470687 Hs 104772 ESTs SS 82

432603 AA554920 Hs 105794 UDP-glucose glycoprotein gluco SSJM 82

402445 Target Exon fπ3,SS,TM,BNR 82

422078 AW872378 Hs 120170 hypothetical protein FLJ21415 SS 82

418361 AW505368 Hs 12460 gb UI-HF-BNO-alu-d-03-0 UI r1 82

431354 BE046956 Hs 251673 DNA (cytosιne-5-)-methyltransf SS.PWWP.PHD 82

403885 Target Exon TM,Sulfate_transp,STAS,HM 82

450029 AW073380 Hs 267963 hypothetical protein FU10535 SS.Pyndox oxιdase,zf-C2H 82

452512 AW363486 Hs 337635 ESTs SS 82

420138 BE268854 Hs 177729 ESTs SS 82

439788 N71241 Hs 119275 ESTs UQ_con 82

423662 AK001035 Hs 130881 B-cell CLL/lymphoma 11 A (zinc SS 82

449656 AA002008 Hs 188633 ESTs PIP5K 81

452295 BE379936 Hs 28866 programmed cell death 10 SS.serpin 81

448650 AW769385 Hs 204891 ESTs SS.IL8 81

446035 NM 006558 Hs 13665 Sam68-lιke phosphotyrosine pro KH-domam 81

444406 AI147237 immunoglobulin heavy constant SS 81

437215 AL117488 Human clone 23564 mRNA sequenc SS 81

408891 NM 006577 Hs 284284 ESTs, Highly similar to beta-1 SS,TM,DIX,PDZ,DEP,Dιsheve 8 1

400409 AF153341 Homo sapiens winged helixffork SS 80

443801 AW206942 Hs 253594 mtron of tπchorhinophalaπg GATA 80

425281 AA444390 Hs 155482 hydroxyxyl glutathione hydrol lactamase.B.SS 80

458216 AW024282 Hs 104938 hypothetical protein MGC15906 80

401507 C15000810*gι|11131272|sp|P793 80

401180 eukaryotic translation elongat SS,TM,ιoπ_trans,IQ 80

454291 AW384847 Hs 213534 ESTs, Weakly similar to MUC2 H SS,XRCC1_N,BRCT,lxtamase 80

444014 AI095718 Hs 135015 ESTs 80

412128 AW894709 gb CM1-NN0032-020500-212 d05 N SCAN,zf-C2H2,KRAB 79

408363 NM 003389 Hs 44396 coronin, xtin-binding protein WD40 79

425694 U51333 Hs 159237 hexokmase 3 (white cell) hexokιnase,hexokιnase2,he 79

425263 NM 001197 Hs 155419 BCL2-ιnterxtιng killer (apopt SSJMJspO MBR 79

447045 AW392394 sorting nexm 17 SS,IF-2B,PP2C 79

457613 AA598869 Hs 173770 ESTs 79

410338 W03445 Hs 38205 gb za05g11 r1 Soares melaπocyt pkinase 79

402545 Target Exon 79

454246 AW245185 Hs 6996 ESTs 79

410079 U94362 Hs 58589 glycogeπiπ 2 Glyco transf 8 79

443678 AW009605 Hs 231923 ESTs SS 79

404676 Target Exon 79

406649 AI569392 gb tn86a02 x1 NCI.CGAP.Ut2 Horn 79

420230 AL034344 Hs 284186 forkhead box C1 ForkJiead.SS.Fork head 79

413534 BE146961 gb QV4-HT0222-011199-019 b12 H SSJM 78

444628 U01120 Hs 242 glucose 6-phosphatase, catalyt PAP2.SSJM 78

410839 NM 006849 Hs 66581 protein disulfide isomerase thιored,Rho_GDI,gntR,SS,T 78 444046 AI360834 Hs 135094 ESTs SS.GTP EFTU.EFG CGTP.EFT 78

439501 AF086321 Hs 287452 Homo sapiens cDNA FU11760 fis TM 78

415441 R13977 Hs 9634 ESTs 78

450461 BE408081 Hs 46736 hypothetical protein FU23476 SS 78

448993 AI471630 KIAA0144 gene product 78

400923 Target Exon SSJM.DUF289 78

440546 AI491994 gb to07g09 x1 NCI CGAP Ut2 Hom SS.HATPase c 78

419757 AA773820 Hs 63970 ESTs SSJM 78

451721 NM 006946 Hs 26915 speclπn, beta, πoπ-erythrocyt specfrιn,PH,CH,SS,Peptιda 78

458834 AI566883 Hs 196446 ESTs 78

422633 X56832 Hs 118804 enolase 3, (beta, muscle) enolase,SS,TM,kιπesm,FHA 77

438452 AI220911 Hs 288959 hypothetical protein FU20920 SS 77

421445 AA913059 Hs 104433 Homo sapiens, done IMAGE 4054 asp,SS,TM,ιon trans.K tet 77

434743 AI363410 πbosomal protein S18 SSJM 77

450635 AW403954 Hs 25237 meseπchymal stem cell protein 4HBT 77

442394 R62926 Hs 285193 ESTs 77

434333 AA186733 Hs 292154 stromal cell protein 77

427221 L15409 Hs 174007 von Hippel-ύndau syndrome VHLJM 77

429099 BE439952 Hs 196177 phosphorylase kinase, gamma 2 pkιπase,SS,SNF2_N,helιcas 77

444670 H58373 Hs 332938 hypothetical protein MGC5370 SS,zf-RanBP,MDM2 77

449495 AI652833 gb wb22c11 x1 NCI CGAP.GC6 Horn SS 77

444607 AW405635 Hs 293687 ESTs SS,PI-PLC-X,PH,PI PLC-Y.C 77

449125 AI671439 Hs 196029 Homo sapiens mRNA for KIAA1657 TIMP 77

447151 AI022813 Hs 92679 Homo sapiens clone CDABP0014 m SS,TM,LRR,amιπotraπ_1_2 76

448626 W27670 Hs 55613 hypothetical protein FLJ22531 76

430432 AB037758 Hs 241419 KIAA1337 protein TM,Patched,TM 76

401822 C17001422 gι|2695866|emb|CAA75 76

428909 AI190714 Hs 98945 ESTs 76

414534 BE257293 Hs 76366 BCL2-antagonιst of cell death SS,hormone_rec,zf C4 76

421620 AA446183 Hs 91885 ESTs, Weakly similar to 155214 76

441650 AI261960 Hs 132545 ESTs SSJM.KOW 76

442232 AI357813 Hs 337460 ESTs, Weakly similar to A47582 SS,TM,TGFb_prapeptιde,TGF 76

439539 BE348395 Hs 121589 ESTs SS.Fork ead 75

400286 C16000922 gι|7499103|pιr||T209 TM.ABC tran.ABC.membraπe 75

452833 BE559681 Hs 30736 KIAA0124 protein WD40 75

417390 AA196552 Hs 85852 hypothetical protein MGC3169 75

427721 AI582843 Hs 180455 RAD23 (S cerevisiae) homolog ubιquιtιn,UBA,ιntegπn_B, 75

450716 T57758 Hs 10255 ESTs 75

407435 AF211976 gb Homo sapiens LENG9 mRNA, pa 75

413956 AI821351 Hs 193133 ESTs, Weakly similar to ALU7.H 75

427899 AA829286 Hs 332053 serum amyloid A1 SS,SAA_protems,SS,SAA_pr 75

406495 Target Exon SRCRJM.Acetyltransf 75

430387 AW372884 Hs 240770 nuclear cap binding protein su rrm.SSJM.rrm 75

408601 U47928 Hs 86122 protein A SS,7tm_1,SS,ιg WD40,zf-UB 75

424364 AW383226 Hs 163834 ESTs, Weakly similar to G01763 SS.ras 74

409832 AW963293 gb EST375366 MAGE resequences, SS 74

448043 AI458653 Hs 201881 ESTs PHD 74

421148 AF008936 Hs 102178 syntaxιπ 16 Syntaxm.SS Peptidase M17 74

420970 AA305079 Hs 1342 cytochrome c oxidase subunit V COX5B 74

419295 BE397712 Hs 144027 ESTs myb.DNA bιndιng,myb_DNA-b 74

448330 AL036449 ESTs 74

419639 AK001502 Hs 91753 hypothetical protein 74

431488 AB037785 Hs 257594 KIAA1364 protein SS,CH,UM,SS 74

456487 AF064804 suppressor of Ty (S cerevisiae 74

448615 AI910868 Hs 212957 ESTs SS 74

427433 D82070 Hs 177972 chromosome 4 open reading fram SS.pkinase 74

441076 N49809 Hs 11197 Homo sapiens, clone IMAGE 3343 74

452554 AW452434 Hs 58006 ESTs, Weakly similar to ALU5.H SS.PAS.HLH 74

411448 AA178955 Hs 271439 ESTs, Weakly similar to I38022 rrm.PDZ 74

442318 AI792199 ESTs SS,zf-C2H2 74

425055 AW961959 Hs 96940 ESTs 74

412935 BE267045 Hs 75064 tubulin-specific chaperone c SS,TM,transmembrane4 74

403748 Target Exon TM 74

447282 AI989963 Hs 197505 ESTs TM 73

422305 AI928242 Hs 293438 ESTs, Highly similar to AF1984 SS 73

416472 AA180756 Hs 340316 ESTs, Moderately similar to AL zf-C2H2 73

427273 AW139032 Hs 107376 hypothetical protein DKFZp434N SS.SSJM 73

412265 AA101325 Hs 86154 hypothetical protein FU12457 UPP_synthetase,HMG14_17 73

447859 AK002194 Hs 19851 peroxisomal biogenesis fxtor 73

432747 NM.014404 Hs 278907 calcium channel, voltage-depen PMP22_Claudιn,SS,TM PMP22 73

406727 AI219282 Hs 2186 eukaryotic translation elongat SS,G-gamma 73

404199 ENSP00000211797* Helicase SKI2 SS,RasGAP,PH,SS,PHD 73

445434 BE391690 Hs 9265 hypothetical protein FU20917 SS,PWWP,Exonuclease,lιpoc 72

428550 AW297880 Hs 98661 ESTs SS,homeobox,homeobox 72

454718 AW815144 gb QV4-ST0212-120 00-075- 10 S SS,ATP-synt ab.ATP-synLa 72

407686 AW901268 Hs 126043 chromosome 21 open reading fra SS,TM,ISK_Channel 72

418304 AA215702 gb zr97g10 r1 NCI_CGAP_GCB1 Ho serpm 72

424263 M77640 Hs 1757 L1 cell adhesion molecule (hyd fπ3,ιg,IRK,SS,TM,frι3,ιg,R 72

407581 R48402 Hs 173508 P3ECSL SS,TM,7tm 1 72

430746 AW977370 Hs 222012 ESTs SS 72

402651 NM.000721* Homo sapiens calciu lon.trans 72

407323 AA181183 Hs 143504 gb zp57c02 s1 Stratagene endot SS,Rιbosomal_S4e,ubιquιtι 72

407619 AL050341 Hs 37165 collagen, type IX, alpha 2 SS,Collagen,SS,Collagen 72

434035 AI762074 Hs 204769 ESTs, Weakly similar to T28770 SSJM 72 400419 AF084545 Target EGF.ig.lectin c,sushι,Xlι 72

424241 AW995948 Hs 182339 Homo sapiens pyruvate dehydrog SAM.PNT 72

445837 AI261700 ESTs 72

427725 U66839 Hs 180533 mitogen-xtivated protein kma pkinase 71

421879 AW959607 gb EST371677 MAGE resequences, 71

418285 H68616 Hs 293756 ESTs SS.EMP24.GP25L 71

442893 H78133 gb yu86c11 s1 Soares fetal liv 71

437829 AI358522 Hs 103834 ESTs 71

450873 BE464016 Hs 238956 ESTs SS,zf-C2H2,rrm 71

433396 AI742071 Hs 133205 ESTs SSJM 71

415595 R54144 Hs 278707 chromosome 21 open reading fra SS 71

436629 AA861011 Hs 249795 ESTs TM 71

414593 BE386764 gb 601273249F1 NIH_MGC_20 Homo 71

422765 AW409701 Hs 578 baculo al IAP repeat-contain BIR,TK,SS,TM 71

419823 AW271708 Hs 118918 ESTs, Weakly similar to M20M.H SSJM 71

405247 Target Exon SS 71

455778 BE088746 gb CM2-BT0693-210300-123-d09 B 71

431005 AA490544 Hs 127269 ESTs, Weakly similar to T02345 WD40 71

435717 AF227905 Hs 105794 UDP-glucose glycoprotein gluco Glyco transf 8 71

405113 Target Exon SS 71

428070 T63918 Hs 182313 retinol-bindmg protein 2, eel lιpocalιn,lιpocalιn,WD40 71

429029 AA443443 Hs 85524 for muscle specific nng finge SS 71

430354 AA954810 Hs 239784 human homolog of Drosophila Sc SSJM.ig 70

412970 AB026436 Hs 177534 dual specificity phosphatase 1 Rhodanese,DSPc,SS,DSPc 70

438701 AA937112 Hs 207788 ESTs TM.sushi 70

454756 AW819273 gb CM2-ST0284-061299-046-a12 S 70

401264 C18000090* gι|6678656|ref|NP_0 SS.Iaminm Ntermjammin 70

408080 AW149754 Hs 248652 ESTs, Weakly similar to T00273 SS 70

418641 BE243136 Hs 86947 a disintegπn and metalloprote dιsιπtegπn,Reprolysιn,Pe 70

431402 AA743534 Hs 250861 ESTs 70

423790 BE152393 gb CM2-HT0323-171199-033 a08 H SS 70

450688 AW272352 Hs 60450 ESTs TM 70

405928 Target Exon SS,cystatιn,Coprogen_oxιd 70

454438 AA224053 cell division cycle 27 SS ,TM,SPRY,7tm_3 ANF.rece 70

407281 AI307226 Hs 164421 ESTs SS 69

423386 AW136098 Hs 314081 ESTs SS,WD40,EPO_TPO 69

459360 BE384526 Hs 25734 gb 601277913F1 NIH.MGC.20 Homo 69

420187 AK001714 Hs 95744 hypothetical protein similar t ank.TM 69

431549 AA507036 Hs 170673 ESTs 69

423384 AL133632 Hs 127808 Homo sapiens mRNA, cDNA DKFZp4 69

454577 AW809272 gb MR4-ST0118040100 034-c08_1 69

438118 AW753311 ESTs SS.Iipocalin 69

416233 AA176633 gb zp13g01 s1 Stratagene fetal 69

417012 N38970 Hs 194214 ESTs 69

452399 BE513301 Hs 29344 hypothetical protein, clone 24 SS peπlipm 69

439963 AW247529 Hs 6793 platelet-activating fxtor xe PAF-AH Ib.Lipase GDSL.SS, 69

418416 U11700 Hs 84999 ATPase, Cu transporting, beta El E2_ATPase,HMA,Hydrolas 69

404956 C1003210* gι|6912582|ref|NP_03 PI3 PI4 kιπase,PI3K C2.PI 69

451606 AA018791 Hs 7945 AIE-75 binding protein protein SS 69

438525 AW368528 Hs 100855 ESTs SS 69

400906 C18000324 g ι| 12229928 |sp]Q9PT W 69

411411 AA345241 Hs 55950 ESTs, Weakly similar to KIAA13 SS 68

406834 AI318680 gb ta49g09 x1 NCI_CGAP_Lu25 Ho 68

414629 AA345824 Hs 76688 carboxylesterase 1 (monocyte/m SS,COesterase,SS,COestera 68

424198 AB029010 Hs 143026 KIAA1087 protein SS,TM,Na_Ca_Ex,Calx-beta 68

445873 AA250970 Hs 251946 poIy(A) binding protein, cytop SS.PABP.rrm pkιnase,14-3- 68

439605 AF086431 Hs 22380 ESTs SSJM 68

432284 AA532807 Hs 105822 ESTs SSJM.pkinase

421904 BE143533 Hs 109309 hypothetical protein FU20035 68

443136 NM 001440 Hs 9018 exostoses (multιple)-lιke 3 Exostosin.SSJM 68

421758 BE397336 Hs 1422 Gardner-Rasheed feline sarcoma SH2,SH3,pkιnase 68

448148 NM.016578 Hs 20509 HBV pX associated proteιn-8 PHD.Virus HS.SS.ICIπ chan 68

400205 NM 006265* Homo sapiens RAD21 SS 68

434315 AW196608 ESTs 68

418184 AA367375 Homo sapiens cDNA FU14015 fis 68

431898 AK000020 Hs 272018 hypothetical protein FLJ20013 67

438627 AI087335 Hs 123473 ESTs TM.Reticulon 67

409649 AA159216 Hs 55505 hypothetical protein FLJ20442 Yjjhosphatase.DSPcJM 67

429712 AW245825 Hs 211914 ENSP00000233627* NADH-ubiquino oxιdored_q6,SS,TM,rrm 67

456886 AW089093 Hs 144996 ESTs, Weakly similar to 138022 67

427461 AA531527 Hs 332040 hypothetical protein MGC13010 SS,TM,ACAT,LRR 67

434000 BE002846 Hs 112964 ESTs 67

432530 AF131786 Hs 278303 Homo sapiens clone 25220 mRNA SS.proteasome 67

436141 AA970001 Hs 150319 Homo sapiens, clone IMAGE 3610 SSJM 67

441794 AW197794 ESTs 67

450287 AW291483 Hs 255909 ESTs 67

441523 AW514263 ESTs, Weakly similar to ALU F H SS 67

452798 AI918771 Hs 257170 ESTs SS,TM,TNFR_c6 67

451937 AF119664 Hs 27299 transcπptional regulator prot SS,ιntegπn_B,fn3,Calx-be 67

421417 AA291004 Hs 326088 ESTs 67

440317 BE561888 gb 601346093F1 NIH.MGC.8 Homo 67

421321 NM 005308 I Hs 103502 glutamic-pyruvate fransamiπase amιnotran_1_2,SS,TM,LRR 67

444904 AW452054 Hs 161139 ESTs 67

449730 R72290 Hs 117557 ESTs, Weakly similar to I38022 RasGAP.thyroglobuIinJ ,Rι 67 450622 AI660285 Hs 58210 ESTs, Highly similarto ITH4.H SSJM.vwa 67

425424 NM 004954 Hs 157199 ELKL motif kinase pkιnase,KA1,UBA,SS 67

435864 AL036499 Hs 188491 ESTs 67

410397 AF217517 Hs 63042 DKFZp564J157 protein SS,homeobox,UPF0160,DUF23 67

454262 AW612232 Hs 254835 ESTs SS,TM,voltage_CLC,CBS 67

453023 AW028733 Hs 31439 seπne protease inhibitor, Kuπ Kunιtz_BPTI,SS ,TM lon ra 66

419157 AA234540 Hs 23871 ESTs pkinase 66

412464 T78141 Hs 22826 ESTs, Weakly similar to 155214 SS.cadheπn crγstall 66

407332 AI801565 Hs 200113 Homo sapiens cDNA FU11379 fis SS.adh.shortJransglutami 66

456643 AW751497 Hs 98370 cytochrome P450, subfamily IIS 66

411490 R39474 gb yh95b09 r1 Soares plxenta SS 66

455885 BE153524 gb PM0 HT0339 241199 002 C03 H SS.pkinase 66

438857 AI627912 Hs 130783 Forssman synthetase SS,RA,RasGEF,RasGEFN 66

420307 AW502869 Hs 66219 ESTs SSJM 66

453496 AA442103 Hs 33084 solute earner family 2 (fxil sugar.tr.SSJM 66

419182 AA234822 Hs 66147 ESTs SSJM.ion trans ion trans 66

406301 Target Exon TM

433938 AF161536 Hs 284292 ubiquinol-cytochrome c reducta TM 66

448980 AL137527 Hs 289038 hypothetical protein MGC4126 66

454095 AW178110 Hs 191705 gb IL3-HT0061-010999 013-H04 H SS TM homeobox frypsin.PD 66

459702 AI204995 gb an03c03 x1 Stratagene schiz 66

422201 NM.001505 Hs 113207 G protein-coupled receptor 30 7tm 1,SS,TM 66

406779 AA412048 Hs 279574 CGI-39 protein, cell death reg SS.SS 66

404149 C6002509* gι|5031885|ref|NP 0 SSJM.kππgle 66

418576 AW968159 Hs 302740 Epithelial calcium channel 2, SSJM 66

421363 NM 001381 Hs 103854 docking protein 1, 62kD (downs PH,IRS,TM,PH,IRS,frypsιn, 66

458919 AI681567 Hs 13349 KIAA0756 protein TM 66

427502 AI811865 Hs 7133 Homo sapiens, clone IMAGE 3161 SS TM ABC tran.Glyco tran 65

412289 AW935967 Hs 170162 KIAA1357 protein SS 65

447105 AW377610 Hs 11123 DKFZP564G092 protein SSJM 65

444672 Z95636 Hs 11669 laminin, alpha 5 laminin EGFJamimn G EGF 65

429299 AI620463 Hs 347408 hypothetical protein MGC13102 SS,TM,gla 65

420003 AA256906 Hs 111364 ESTs, Weakly similar to ubiqui SSJM 65

431849 AI670823 Hs 85573 hypothetical protein MGC10911 SS TM 65

430396 D49742 Hs 241363 hyaluronan binding protein 2 trypsin.kπngle EGF.SS 65

437662 AA765387 ESTs WD40,RCC1,SPRY 65

436543 NM.002212 Hs 5215 integnn beta 4 binding protei elF6 65

405375 CX000741* gι|4885461]ref|NP_00 SSJM 65

430116 AA465350 Hs 119400 ESTs SSJM adh.short 65

406109 Target Exon 65

414871 BE549179 Hs 29008 gb 601078714F1 NIH MGC 12 Homo 65

440656 AI979248 Hs 148221 ESTs 65

438951 U51336 Hs 6453 inositol 1,3,4-tπphosphate 5/ SS.oxidored nitro.SS 65

405376 Target Exon SS TM 65

426925 NM.001196 Hs 315689 Homo sapiens cDNA FLJ22373 fl SS 65

400500 Target Exon 65

408294 BE141732 gb QV0-HT0101-061099 032-e07 H Ammonium.fransp 65

447904 AW206303 ESTs 64

439211 AI890347 Hs 271923 Homo sapiens cDNA FLJ22785 fi SS 64

426828 NM 000020 Hs 172670 activin A receptor type ll-lik pkiπase.Activin recp.SS T 64

446100 AW967109 Hs 13804 hypothetical protein dJ462023 SSJM 64

442146 R52599 gb yg81g01 r1 Soares infant br TM 64

425041 AI377150 Hs 150914 ESTs SS 64

457584 AA147979 Hs 285005 mitochondπal import receptor Josephin 64

435449 AA682379 Hs 303460 EST 64

406284 Homo sapiens mRNA full length 64

425944 AK000664 Hs 164256 hypothetical protein FU20657 64

453367 AW732847 Hs 70573 PKCI-1-related HIT protein SSJM 64

419725 U66048 Hs 92683 Homo sapiens clone 161455 brea 64

412452 AA215731 suppression of tumoπgenicity SS 64

421273 AJ245416 Hs 103106 U6 sπRNA associated Sm like pr Sm,SS,tRNA synt 1.GST C,G 64

432746 AA564512 Hs 24301 polymerase (RNA) II (DNA direc SSJM.EF1BD 64

429398 AA452239 KIAA0970 protein 64

404430 C8000066* gι|10432395|emb|CAC1 SS 64

427339 A1734109 Hs 97984 SRY (sex determining region Y) 64

436389 AI811706 CHMP1 5 protein 64

428890 AA525226 Hs 303293 ESTs, Moderately similarto 15 64

445333 BE537641 Hs 44278 hypothetical protein FU12538 SS 64

414756 AW451101 Hs 159489 ESTs, Moderately similar to JC hexokιnase2,hexokιnase 64

423847 U16997 Hs 133314 RAR related orphan receptor C hormone rec,zf-C4,SS,TM,h 64

408493 BE206854 Hs 46039 phosphoglycerate mutase 2 (mus PGAM,BRCT,RNA pol L 64

439569 AW602166 Hs 222399 CEGP1 protein CUB,EGF,SS 64

457274 AW674193 Hs 227152 mannan binding lectiπ senne p SSJM SSJM Clathπnjg c 64

444550 BE250716 Hs 87614 ESTs SS 64

407198 H91679 gb yv04a07 s1 Soares fetal liv BIR 64

423228 AL137491 Hs 125511 Homo sapiens mRNA, cDNA DKFZp4 SS.TM.sushi 64

422682 W05238 Hs 94316 ESTs, Weakly similar to T31613 SS,TM,DEAD,helιcase C.Lam 63

447887 AA114050 Hs 19949 caspase 8, apoptosis related c ICE_p20,DED,ICE_p10 63

400137 Eos Control 63

408784 AW971350 Hs 63386 ESTs SS 63

435028 AW193035 Hs 187370 ESTs 63

438113 AI467908 Hs 8882 ESTs SS,TM,7tm_1 63

417810 D28419 Hs 82609 hydraxymethylbilane synthase Porphobil.deam 63

436050 AI057205 Hs 14584 ESTs 63 403672 C4001244 gι|539933|pιr||A61275 tubulmJM 63

448269 BE622358 Hs 61260 hypothetical protein FU13164 63

430217 N47863 Hs 180450 πbosomal protein S24 Rιbosomal_S24e 63

426675 AW084791 Hs 133122 hypothetical protein FU14524 SS,TM,ammotran_1_2 63

423510 AB000824 Hs 129712 trehalase (brush-border membra Trehalase 63

428573 AA430651 Hs 209249 ESTs 63

457052 BE167242 Hs 47099 hypothetical protein FU21212 SS 63

445099 BE163341 gb QV3-HT0458-230200-099 b01 H 63

450334 AF035959 Hs 24879 phosphatidic xid phosphatase PAP2.SS 63

416000 R82342 Hs 79856 ESTs, Weakly similarto S65657 SSJM sugar.tr 63

427880 AA436011 Hs 98187 ESTs 63

426722 U53823 Hs 171952 occludm Occludιn,SS,TM,BIR 63

452072 BE258857 Hs 27744 RAB3A, member RAS oncogene fam ras,arf,SS,PDEase 62

431161 AA493591 gb nh01a12 s1 NCI.CGAP.Thyl Ho SS 62

413055 AV655701 Hs 75183 cytochrome P450, subfamily HE p450 62

431250 BE264649 Hs251377 taxol resistance associated ge 62

406373 Target Exon SS,TM,vwa,FG-GAP,ιntegnn 62

403003 NM.024944* Homo sapiens hypoth TM 62

437834 AA769294 gb nz36g03 s1 NCI.CGAP.GCB1 Ho SS 62

406299 Target Exon 62

439327 AF086141 Hs 50760 ESTs, Highly similar to BimL [ SS 62

414246 BE391090 Hs 280278 EST 62

427812 AA770424 Hs 98162 ESTs SS 62

420926 AA830402 Hs 221216 ESTs UQ_coπ 62

443766 N91071 Hs 109650 ESTs 62

431082 AA491600 gb ne80a11 si NCI_CGAP_Ew1 Horn 62

420530 AI218431 coagulation fxtor Vlll-associ 62

407360 X13075 gb Human 2a12 mRNA for kappa i 62

449008 AW578003 Hs 22826 tropomodulm 3 (ubiquitous) 62

409946 AW162263 Hs 312468 ESTs, Weakly similar to ALUC.H RasGAP,C2,PH,BTK 62

413272 AA127923 ESTs SS 62

445050 AW205483 Hs 147260 ESTs SS,trypsιn,kπngle,frι2,EG 62

458130 AA115811 Hs 6838 ras homolog gene family, membe ras.arf 62

449940 AW291126 Hs 187520 Homo sapiens, clone IMAGE 3834 SS,zf-C2H2 62

440390 AW207385 Hs 36475 KIAA0493 protein 62

423106 N52572 Hs 13702 ESTs, Moderately similar to AL 62

402501 sperm specific antigen 2 ιg,MHC_l,SS 61

431470 AA832417 Hs 139650 ESTs SS,ιg pkιnase,LRR,LRRCT 61

416597 H66891 gb yr71c03 r1 Soares fetal liv 61

412122 AW852707 G πch RNA sequence binding fa SS.WD40 61

415056 AB004662 Hs 77867 adenosmeAI receptor 7tm_1,SS,TM 61

400358 AF181286 Homo sapiens mutant dystrophm 61

405473 NM.001093* Homo sapiens acetyl CPSase_L_chaιn,bιotιn_lιp 61

422625 AW504698 Hs 155976 cull 4B SS,SS,Cullιn,Cullιn 61

422262 AL022315 Hs 113987 lectin, galxtoside-binding, s Gal bindjectm 61

401121 C12001638* gι|7291960|gb|AAF47 61

425188 AK002052 Hs 155071 hypothetical protein FU11190 TM 61

457216 AA452554 Hs 283697 ESTs, Weakly similar to A41796 bZIP Maf,SS,P5CR,EF1BD 61

456021 BE246628 Hs 250726 gb TCBAP1D5030 Pediatπc pre-B SSJM.SS 61

420319 AW406289 Hs 96593 hypothetical protein ras.arf 61

410082 AA081594 Hs 158311 Musashi (Drosophila) homolog 1 SS,HECT,phoslιp 61

450593 AF129085 Hs 25197 STIP1 homology and U Box conta TPR,SS,TM,Rhomboιd,lxtam 61

437050 AA766420 ESTs SS 61

458835 AI868753 Hs 76372 ESTs SS 61

412777 AI335773 ESTs 61

454364 BE263928 Hs 323806 gb 601191272F1 NIH.MGC 7 Homo SSJM 61

448877 AI583696 Hs 253313 ESTs 61

413045 X92121 Hs 75180 protein phosphatase 5, catalyt MetallophosJPR 61

408054 AW816490 Hs 8102 ESTs 61

417852 AJ250562 Hs 82749 transmembrane 4 superfamily me traπsmembrane4,SS,TM 61

410445 AA199830 gb zq75h01 r1 Stratagene hNT n 61

415870 H15578 Hs 21017 ESTs 61

438723 M34429 gb Human PVT-IGLC fusion prate 61

441307 AW071696 Hs 209065 hypothetical protein FU14225 SSJM 60

406575 Target Exon SS,pkmase,pkιnase_C,RFX_ 60

401488 Target Exon Glyco.hydro.1 60

437650 AA814338 Hs 292297 ESTs 60

439827 AA846538 Hs 187389 ESTs pkιnase,DAG_PE-bιnd,PH 60

456373 BE247706 Hs 89751 membrane-spanning 4-domaιns, s SSJM 60

454513 BE159271 Hs 109731 gb MRO-HT0407-180100-004-h05 H 60

414944 C15044 gb C15044 Clontech human aorta SSJM 60

451277 AK001123 Hs 26176 hypothetical protein FU10261 TM,SS,TM,death,DED 60

421190 U95031 Hs 102482 mucm 5, subtype B, trxheobro Cys.knot.vwc 60

401215 C12000457* gι|7512178|pιr||T30 trypsm.SSJM 60

408117 AL138255 ESTs, Weakly similarto 138022 SS,zf-C3HC4,BIR 60

426357 AW753757 Hs 12396 gb RC3-CT0283-271099-021-a08 C 60

418630 AI351311 Hs 251946 poly(A)-bιndιng protein, cytop SS.pkinase 60

400389 AL135841 olfactory receptor, family 2, 7tm_1,SS,TM,CSD 60

447128 AI271898 cyclin K 60

431297 AA651771 Hs 3076 ESTs 60

431857 W19144 Hs 271742 ADP-πbosylfraπsferase (NAD, p PARP,PARP_reg,SS,TM,Peptι 60

430023 AA158243 Hs 227729 FK506-bιndιng protein 2 (13kD) SS,FKBP,SS,PDGF,C2,PI-PLC 60

453101 AW952776 Hs 94943 ESTs TM 60

407383 AA532576 ESTs, Moderately similar to AL SS,Patatιn,ank 60 430132 AA204686 Hs 234149 hypothetical protein FU20647 SS,SS,TM,ιg 60

459111 AU077013 Hs 28757 transmembrane 9 superfamily me EMP70 60

405770 NMJ02362 Homo sapiens melanom MAGE 60

415611 T26376 gb AB123C11R Infant brain, LLN SS,TM,rrm,sushι 60

453413 AJ003294 gb AJ003294 Selected chromosom SS.Folate.carπer 60

424415 NM 001975 Hs 146580 enolase 2, (gamma, neuronal) enolase,SS,Atrophιπ-1 ,Atr 59

426048 AI768853 Hs 134478 ESTs TM 59

435750 AB029012 Hs 4990 KIAA1089 protein SSJM 59

439469 W69836 gb zd48a02 r1 Soares etal.hea SS,pkιnase,C2,pkιnase_C,D 59

445664 AW968638 Hs 237691 ESTs, Weakly similar to KIAA06 59

418830 BE513731 Hs 88959 hypothetical protein MGC4816 TM.CDP-OH.P.transf 59

452113 AI859393 gb wml 1a02 x1 NCI_CGAP_Ut4 Horn actin 59

449101 AA205847 Hs 23016 G protein-coupled receptor 7tm_1,SS,TM 59

437640 AA764893 Hs 272155 ESTs, Weakly similarto 138022 59

400748 NM 022122 Homo sapiens matπx SS,Peptιdase_M10,hemopexι 59

442370 AI143593 Hs 129419 ESTs 59

442419 AI749893 Hs 270532 ESTs, Weakly similar to I38022 Adaptm N.AIpha adaptιπC2 59

439986 AW750272 Hs 128608 ESTs SSJMJSK Channel 59

407553 Z11168 gb H sapiens 5HT1A receptor re SSJM 59

431424 AI222969 ESTs SS 59

442297 NM.006202 Hs 89901 phosphodiesterase 4A, cAMP-spe PDEase 59

457845 H93040 Hs 297729 ESTs SSJM.WD40 59

446912 AI347650 Hs 128521 ESTs, Moderately similar to AL SS 59

451381 BE241831 Hs 172330 hypothetical protein MGC2705 SS,Rιbosomal_L28e 59

416024 AW886484 Hs 343522 ATPase, Ca transporting, plasm E1-E2_ATPase,Hydrolase,Ca 59

446329 NM 013272 Hs 14805 solute earner family 21 (orga kazal.OATP.N.OATP.C 59

431321 AW136372 Hs 1852 xid phosphatase, prostate SS,TM,xid_phosphat 59

420039 NM 004605 Hs 94581 sulfotransferase family, cytos Sulfotransfer.SS.DAGKc 59

428223 AA424313 Hs 98402 ESTs HECT 59

433333 AI016521 Hs 1816 v-akt muπne thymoma viral one homeobox,pkιnase,PH,pkιna 59

450251 BE080483 gb QV1-BT0630-280200 086-a05 B SS 59

408511 AW206404 Hs 27268 ESTs 59

414348 AF041430 Hs 75922 brain protein 13 SS.SH3 59

456950 AF111170 Hs 306165 Homo sapiens 14q32 Jagged2 gen SSJM.DSL 59

412173 T71071 gb yc50b05 r1 Stratagene liver CPSase.L.chain 58

404001 Target Exon 58

445263 H57646 Hs 42586 KIAA1560 protein SS 58

441583 AI791499 Hs 205742 ESTs, Weakly similar to ALUA H 58

430168 AW968343 DKFZP434I1735 protein SS,TM,efhaπd,efhand 58

454682 AW816029 gb MR3-ST0220-151299 027-b10 S filament 58

453829 AL138200 gb DKFZp547N052_r1 547 (synoπy SS,TM,ATP-synLC,Galactos 58

437372 AA323968 Hs 283631 hypothetical protein DKFZp547G SS 58

421726 AK001237 Hs 319088 hypothetical protein FU 10375 TM 58

451045 AA215672 gb zr96e09 s1 NCI.CGAP.GCBI Ho SS,Peptιdase_C1,zf-C2H2 58

439616 BE018635 Hs 58582 Homo sapiens cDNA FU12789 fis SSJM 58

455679 BE066529 gb RC3-BT0333-300300 017-a12 B UBX 58

457125 AW444451 Hs 134812 ESTs SS 58

430600 AW950967 Hs 274348 HLA-B associated transcπpt-3 ubιquιtιn,SS,TM,G-patch,a 58

421707 NM 014921 Hs 107054 lectomedin-2 Latrophιlιn,OLF,7tm_2,Gal 58

436127 W94824 Hs 11565 RIKEN cDNA 2010100012 gene Corona 7,SS,TM 58

414347 BE275835 gb 601121639F1 NIH MGC 20 Homo SS 58

439910 H66765 Hs 339397 ESTs SS 58

410382 AW664971 Hs 259546 ESTs UM 58

426391 AW161050 Hs 169611 second mitochondπa deπved ac SS 58

423358 AI815474 Hs 343866 gb au47f10 y1 Schneider fetal SS 58

440146 AW014231 Hs 90790 Homo sapiens cDNA FU22930 fi Peplιdase_M1 58

402189 ENSP00000247423* D-siglec prec 58

439949 AW979197 Hs 292073 ESTs, Weakly similar to ALU7.H 58

457978 AA776638 gb ae78g04s1 Stratagene schiz SS,PH,IQ,RasGEF,RasGEFN,R 58

436685 W28661 Hs 5288 Homo sapiens mRNA, cDNA DKFZp4 SS,TM,pkmase,Actιvιn rec 58

411602 L01406 Hs 767 growth hormone releasing hormo 7tm 2.HRM 58

433357 T05639 gb EST03528 Fetal brain, Strat SS 58

404311 Target Exon TM 58

428092 AW879141 ESTs SSJM 58

452620 AA436504 Hs 119286 ESTs SS 58

401938 Target Exon SS.PHD.proteasome 57

407202 N58172 Hs 109370 ESTs SS.F5 F8 type C,pkιnase,E 57

458882 R34993 Hs 226666 ESTs, Moderately similar to 15 SS.CRAL TRIO.PKI 57

452357 AI638176 Hs 283865 ESTs SS,TM,SS,TM 57

452625 AA724771 Hs 61425 ESTs 57

430281 AI878842 Hs 237924 CGI-69 protein mito carr.SSJM 57

430490 AW902951 Hs 301723 Homo sapiens cDNA FU 12974 fis TM 57

450122 BE313765 Hs 343443 ESTs, Weakly similarto I38022 SSJM.Y phosphatase,LON,A 57

450801 AI739013 Hs 203348 ESTs SS,TM,Hmt,HH signal 57

413413 D82520 Hs 132390 zinc finger protein 36 (KOX 18 SS,rrm,DUF185 57

445631 AK001822 Homo sapiens cDNA FU10960 fis 57

419390 AI701162 Hs 90207 hypothetical protein MGC11138 SS,TM,PMP22_Claudιn,PMP22 57

423139 AW402725 Hs 288560 hypothetical protein FU21106 57

426221 AB007881 KIAA0421 protein PI3_PI4_kιnase,FATC,SS,TM 57

443785 AW449952 Hs 190125 basic-helix-loop-helix-PAS pro 57

417900 BE250127 Hs 82906 CDC20 (cell division cycle 20, WD40,SS,TM,fn3,EGF,fn3,ιg 57

446596 AW204515 Hs 156113 ESTs, Weakly similarto G01025 57

432353 NM 016558 Hs 274411 SCAN domain-containing 1 SCAN 57

427625 AF008216 Hs 285013 putative human HLA class II as 57 421543 AK000519 Hs 105606 hypothetical protein FU20512 TM 57

418087 AA961613 Hs 127838 ESTs 57

432751 AF152099 Hs 278911 iπlerleukm 17C SS 57

433943 AA992805 Hs 44865 lymphoid enhancer-binding fxt 57

414274 AW300961 Hs 334684 Homo sapiens, clone IMAGE 4127 SS,Vps26,Acyl-CoA_dh 57

431328 AA502999 Hs 291591 ESTs 57

451481 AA300228 Hs 295866 hypothetical protein DKFZp434N 57

430344 AA476827 Hs 171012 hypothetical protein FU22349 HLH 56

419516 H82550 ATP-binding cassette, sub-fami SS,TM,ABC_tran,ABC_membra 56

413564 BE260120 gb 601146990F1 NIH.MGC.19 Homo 56

415958 H10942 gb ym06c11 r1 Soares infant br SSJM 56

401402 Target Exon 56

456145 BE299427 Hs 21446 KIAA1716 protein SS,DIX,PDZ,DEP,Dιshevelle 56

431536 AL133066 Hs 341906 ESTs TM,SAM_decarbox,SS,pkιnas 56

456266 L29073 Hs 198726 cold shock domain protein A CSD,homeobox,SS,TM,7tm_2, 56

435800 AI248285 Hs 118348 ESTs TM.ECH.chromo 56

449285 AI912702 Hs 139135 ESTs 56

418256 AW845318 Hs 12271 f-box and leucme-πch repeat SS,SS,TM,HSF_DNA-bιnd 56

417442 AA199940 Hs 124039 ESTs 56

405931 Target Exon 56

455286 BE144384 gb MR0-HT0166-191199-004-C11 H SS 56

446931 AI348856 Hs 21627 gb tb05a05 x2 NCI CGAP Lu26 Ho 56

446548 AI769392 Hs 200215 ESTs SS,TM,Rιbosomal_S25,sugar 56

401984 C17000146* gι|2143629|pιr||A57 pkιnase,SS,TM,P2X_recepto 56

404066 Target Exon ^ SS,tRNA-syπL2b,HGTP_antι 56

418363 AA218628 Hs 202977 ESTs 56

458198 AI286100 ESTs 56

432278 AL137506 Hs 274256 hypothetical protein FU23563 SSJM.GNS1 SUR4,SS,TM,Rho 56

432328 AI572739 Hs 195471 6-phosphofructo-2-kιnase/fruct PGAM.6PF2K 56

421871 AK001416 Hs 306122 glycoprotein, synaptic 2 TM,Steroιd dh.SS 56

415514 F11301 Hs 138329 ESTs SSJM 56

426208 AI370379 Hs 132216 ESTs SSJM 56

429367 AB007867 Hs 278311 plexm B1 Sema,PSI,TIG,SS,TM,TIG,Se 56

405939 Target Exon 56

457331 AV647405 Hs 18443 aldehyde dehydrogenase 8 famil GTP EFTU 56

438705 A1049624 Hs 283390 ESTs, Weakly similar to 210926 SS,E2F_TDP,E2F_TDP 56

428624 AI125222 Hs 98712 hypothetical protein DKFZp434H SS,TM,ras,MSP domain 56

419389 AI074951 Hs 319095 ESTs SS.DPPIV.NJerm 56

447595 AW379130 Hs 18953 phosphodiesterase 9A PDEase 56

408015 AW136771 -Hs 244349 epidermal differentiation comp 56

413041 BE061580 Hs 61622 gb MR0-BT0249 091299-201-c07 B SS 55

452849 AF044924 Hs 30792 hook2 protein bZIP,SS,AhpC-TSA 55

434357 AW732284 Hs 3828 mevalonate (diphospho) dxarbo GHMP.kmases.SSJM 55

455274 BE151622 gb PMO-HT0302-271099001-a08 H SSTM,RNA_pol_L 55

453904 AW003821 ESTs 55

424624 AB032947 Hs 151301 Ca2*dependent xtivator protei Fork.head 55

426576 AA381720 gb EST94853 Activated T-cells vwa,ιntegrιn_A,FG-GAP 55

440682 AW362152 Hs 27181 nuclear receptor binding fxto 55

419125 AA642452 Hs 130881 B-cell CLL/lymphoma 11 A (zinc SS 55

450207 T87615 Hs 14716 ESTs 55

405211 C7000900 gι|4508027|ref|NP 003 SS 55

413937 H65775 Hs 207915 ESTs 55

426793 X89887 Hs 172350 HIR (histone cell cycle regula WD40,Clathπn,Clathπn_pr 55

412091 R06185 gb ye94d03 ri Soares fetal liv SS,TM,IBR,IBR 55

446536 W74413 Hs 15251 hypothetical protein SS 55

451117 AA015752 Hs 205173 ESTs 55

409547 AW409885 Hs 335877 Homo sapiens, clone MGC 4558, TM 55

412673 AL042957 Hs 31845 ESTs 55

426440 BE382756 Hs 169902 solute earner family 2 (fxil sugar_tr,SS,TM,sugar_tr 55

449225 R39108 Hs 6777 ESTs SS,TM,Na_sulph_symp 55

403938 Target Exon Ephπn 55

441197 BE244638 Hs 166 sterol regulatory element bind HLH 55

455604 BE011183 gb PM3-BN0218-10050Q-θα3-d09 B 55

457468 AW971345 Hs 292715 ESTs 55

447677 AI419235 Hs 344456 gb tf21d02 x1 NCI CGAP Brn23 H SS,zf-C2H2,SCAN,SCAN,zf-C 55

415473 R39986 Hs 12778 ESTs TM.ion.trans 55

408422 AW977031 Hs 143554 ESTs, Highly similarto B45036 55

442780 AI017521 ESTs SS,TM,7tm 1 55

451558 NM 001089 i Hs 26630 ATP-binding cassette, sub-fami ABC fran,SRP54,SS,TM,ECH 55

439422 AW452791 Hs 249625 ESTs SSJM 55

423479 NM.014326 Hs 129208 death-associated protein kmas pkinase 55

459558 AI539821 Hs 298799 ESTs, Weakly similar to 210926 SS 55

441187 AW195237 Hs 7734 hypothetical protein FU22174 SS,TM,tubulιn 55

420894 AA744597 Hs 88854 ESTs SS.ank 55

404710 C9001584 gι|7499208|pιr||T2099 55

447827 U73727 Hs 19718 protein tyrosine phosphatase, Y_phosphatase,frι3,ιg,MAM, 55

448387 AI874402 Hs 292590 ESTs 55

419541 AW749617 Hs 280776 tankyrase, TRF1-ιnterxtιng an 55

449686 AW072813 Hs 270868 ESTs, Moderately similar to AL 55

426315 AA854219 Hs 348137 Homo sapiens, clone IMAGE 3542 SS.crystall 55

451312 AI769831 Hs 337054 ESTs SS 55

432538 BE258332 Hs 278362 male-enhanced antigen SS,TM AAA,Rιbosomal L2 55

446790 AW452105 ESTs SS,zf C2H2 55

448682 T09471 Hs 250820 hypothetical protein FU14827 55 425234 AW152225 Hs 165909 ESTs, Weakly similar to I38022 SS 55

411219 AW832917 gb QV2-TT0003-161199-013-h06 T 55

439742 AI827721 Hs 284298 Homo sapiens mRNA full length SS 55

432004 BE018302 Hs 2894 plxental growth fxtor, vascu PDGF.SS 55

402916 ENSP00000202587* Bicarbonate t HC03 cotransp.SS 55

405346 Rag C protein RCC1 55

415976 R43144 Hs 21919 ESTs TM 54

435064 T70740 Hs 31433 ESTs SS.MDM2 54

440024 AA969333 Hs 160098 ESTs 54

431525 AA506656 Hs 6185 KIAA1557 protein 54

458644 AW270149 ESTs, Moderately similarto GG 54

410895 AW809679 gb MR4-ST0124-261099 015-fOS S 54

441350 AB020690 Hs 7782 paraneoplastic antigen MA2 54

413034 BE392896 Hs 129126 Homo sapiens, clone MGC 10992, SS 54

444664 N26362 Hs 11615 map kinase phosphatase like pr DSPc,Rhodaπese,SS,TM 54

443887 NM 004729 Hs 9933 Ac-like fransposable element zf-BED 54

445871 AI702901 Hs 145582 ESTs, Weakly similar to FOR4 M SS,TM,efhand,efhand 54

411992 AW816214 Hs 143055 ESTs SSJM 54

458341 AW373583 Hs 221994 gb QV4-BT0534-281299-053-e08 B 54

451677 AA059222 Hs 33538 ESTs, Weakly similar to oxygen 54

432656 NM 000246 Hs 3076 MHC class II transxtivator LRR 54

417739 Z43995 gb HSC1QB121 normalized infant SS,ArfGap,vwa,TSPN,fn3,Co 54

424618 L29472 Hs 1802 major histocompatibility compl TM,ιg,MHC II beta,SS,TM,A 54

446847 T51454 Hs 82845 Homo sapiens cDNA FLJ21930 fi SS,TM,BNR,fn3,ldl_recepL 54

436094 AI798701 ESTs 54

433168 AI085436 gb ow84g06 si Soares.fetal liv SSJM.PID 54

417359 T99264 Hs 191117 ESTs 54

436014 AF281134 Hs 283741 exosome component Rrp46 RNase PH.RNase PH CSSJG 54

435154 AA668764 Hs 301637 ESTs SSJM 54

431630 NM 002204 Hs 265829 mtegππ, alpha 3 (antigen CD4 ιntegπn_A,FG-GAP,Rhabd_g 54

444064 W85970 Hs 16292 ESTs SSJM.Dihydroorotase 54

415970 H23333 Hs 29002 KIAA1706 protein 54

445303 AW362198 Hs 12503 interieukin 15 receptor, alpha SS,sushι,SS 54

421542 AA411607 Hs 118964 ESTs, Weakly similar to KIAA11 SS.SS 54

459704 AA719572 Hs 274441 Homo sapiens mRNA, cDNA DKFZp4 54

402285 sclerostin SSJM 54

431543 AW969619 Hs 259768 adeπylate cyclase 1 (brain) TM 54

431534 AL137531 Hs 258890 Homo sapiens mRNA, cDNA DKFZp4 SSJM.ras 54

417516 AA203473 Hs 81529 ESTs TM 54

423233 BE048021 Hs 11067 ESTs, Highly similar to T46395 54

420733 AW291446 Hs 88651 ESTs SS 54

404807 Target Exon UPF0027 54

436483 AJ272063 Hs 283010 vanilloid receptor subtype 1 SS,TM,aπk,ιon_trans,SS,TM 54

425316 AA354977 Hs 99010 ESTs, Moderately similar to T1 SS,pkιnase,ιg 54

425565 AA359485 Hs 173084 gb EST68511 Fetal lung II Homo 54

413341 H78472 Hs 191325 ESTs, Weakly similar to T18967 54

401203 Target Exon filament 54

422452 AL110255 Hs 116808 Homo sapiens mRNA, cDNA DKFZpδ SS.asp.PGAM 54

436718 AW015227 Hs 289053 hypothetical protein FU 14733 SSJM 54

428501 AL041162 Hs 98587 ESTs TM 54

439695 W28548 Hs 285050 ESTs TM ιon_trans,KJetra,Kv2c 53

417514 AA203445 Hs 325819 ESTs 53

441358 AW173212 ESTs 53

401722 Target Exon TM,PLAT,SS 53

408905 AV655783 Hs 661 Target CAT 53

454453 AW752781 hypothetical protein FU12614 53

410312 AW850953 Hs 75350 gb IL3-CT0220-150200-068-A11 C Vinculm 53

437926 BE383605 Hs 300816 small GTP-bmding protein SSJMJPR 53

458682 AV659151 Hs 282961 ESTs 53

411605 AW006831 ESTs TM.synaptobrevin 53

409164 AA706639 gb ag90e09 r1 Stratagene hNT n SS,TM,Hιnt,HH_sιgnal,tubu 53

438868 AW246243 Hs 334800 hypothetical protein FLJ20974 53

439034 AF075083 gb Homo sapiens full length in filament,filament 53

411426 BE141714 gb QV0-HT0101-061099-032-O04 H SS 53

428186 AW504300 Hs 295605 mannosidase, alpha, class 2A, Glyco hydro 38,SS,TM,Pept 53

438470 AW936329 Hs 227823 pM5 protein SSJM 53

427789 AA412428 Hs 8642 hypothetical protein FLJ23093 53

430230 BE257724 Hs 236361 seb4D rrm,SS,2-Hxιd_DH,WD40 53

434314 BE392921 Hs 3797 RAB26, member RAS oncogene fam ras.arf.SS 53

428539 AW410063 Hs 184877 solute earner family 25 (mito mιto_carr,SS,TM,profilιπ, 53

414927 T83587 Hs 186476 ESTs SS.SuIfatase 53

404596 Target Exon SS 53

454151 AA047169 Hs 154088 hypothetical protein FU22756 SS,TM,GIycos_traπsf_4 53

431627 AW609720 HSPC042 protein 53

422379 AA932860 Hs 133864 ESTs 53

426765 AA743603 Hs 172108 nucleopoπn 88kD MAM33 53

433325 AW206986 Hs 143905 ESTs SS 53

403128 KIAA1033 protein SS,TM,tubulιn,EGF,F5_F8 53

447730 AI421251 Hs 114085 Homo sapiens mRNA for KIAA1755 SSJransglutamm.CJransg 53

405085 Target Exon SS,SS,SNF2_N,helιcase_C 53

438080 AA777381 Hs 291530 ESTs, Weakly similar to ALUC.H 53

439091 AA830144 Hs 135613 ESTs, Moderately similar to 13 KH-domain 53

427326 AI287878 gb qv23f06 x1 NCI.CGAP.Lymδ Ho SS,TM,7tm_1,SS,TM 53

427859 AA416856 Hs 98170 ESTs SS,TM,DUF60,trypsm,CUB,u 53 421779 AI879159 Hs 108219 wingless-type MMTV integration SS,wnt,SS 53

408270 AW177805 gb IL3-HT0059-180899 007-B06 H 53

418437 AA771738 Hs 348000 ESTs, Moderately similar to AL 53

409879 BE083422 Hs 56851 hypothetical protein MGC2668 SSJM 53

428304 AI743177 ESTs SSJM 53

418678 NM.001327 Hs 167379 cancer/testis antigen (NY-ESO- SS,TM,zf-C2H2 53

436540 BE397032 Hs 14468 hypothetical protein MGC14226 SSJM 52

437161 AA054477 Hs 25391 ESTs SSJM 52

400171 ENSP00000211797 Helicase SKI2W SS.proteasome 52

431461 BE299671 Hs 256310 likely ortholog of mouse ZFP28 52

402197 Target Exon SS,TM,ATP1G1_PLM_MAT8,ιg, 52

449514 AW970440 Hs 23642 protein predicted by clone 236 SS,PX,arf,lιpocalιn,PHD,z 52

442472 AW806859 gb MRO-ST0020-081199 004-C03 S SS,TM,lnos-1-P_synth,Occl 52

409679 BE250521 ras homolog gene family, membe SS,homeobox,CUT 52

439150 AF086006 gb Homo sapiens full length in SS 52

412934 BE011437 gb CM4-BN0220 080500-170 f03 B 52

435186 AL119470 ESTs SS 52

400668 Target Exon CARD,ICE_p20,SS,ICE_p20,l 52

409125 R17268 Hs 343567 axonal transport of synaptic v SS,kιnesιn,PH,FHA,kιnesιπ 52

445904 AW449920 Hs 248855 ESTs SS.homeobox 52

414567 BE281057 Hs 184519 hypothetical protein FU12949 SS,TM,ank,Adap_comp_sub 52

414551 AI815639 Hs 76394 enoyl Coenzyme A hydratase, sh ECH,Peptιdase_U7,SS,TM 52

432872 AI908984 Hs 279623 selenoprotein X, 1 DUF25,SS,Rιbosomal_L3,PDZ 52

419492 AA243547 Hs 19447 PDZ-LIM protein mystique LIM,SS,SH3,Sorb,Metalloph 52

407478 L77559 gb Homo sapiens DGS B partial 52

457892 AA744389 gb πy51e10 sl^'NCI_CGAP_Pr18 Ho 52

457228 U15177 Hs 206984 Human cosmid CRI-JC2015 at D10 6PF2K.PGAM 52

437536 X91221 Hs 144465 ESTs SS,TM,Na_Ca_Ex 52

420285 AA258124 Hs 293878 ESTs, Moderately similar to ZN 52

431275 T56571 Hs 10041 ESTs SS.HLH 52

428021 AI022287 Hs 111991 ESTs, Weakly similar to T33900 SS 52

422400 AA974434 Hs 128353 ESTs 52

446442 BE221533 Hs 257858 ESTs 52

415585 R59946 Hs 184852 KIAA1553 protein SS 52

438429 D16918 Hs 12547 Homo sapiens cDNA FLJ23388 fi TM 52

401677 BAI1-ass∞ιated protein 3 SS,TM,zf-C2H2,kιπesιn,Vau 52

405637 Target Exon 52

450437 X13956 Hs 24998 hypothetical protein MGC10471 SS 52

408215 BE614290 syntaxm 10 SS,SS,TM,HLH,TRM,zf CCCH 52

452666 AW194601 Hs 13219 ESTs PI-PLC-X,PI-PLC-Y,C2,PH 52

401553 Target Exon 52

447541 AK000288 Hs 18800 hypothetical protein FLJ20281 zf-CCHC 52

453434 AJ271378 Hs 333243 ESTs 52

450351 BE547267 Hs 59791 hypothetical protein MGC13183 SSJM 52

411456 AW847588 gb IL3-CT0213-161299 038-G09 C SSJM 52

445634 AI624849 Hs 344612 ESTs, Weakly similar to NEL1.H vwd 52

453740 AL120295 Hs 311809 ESTs, Moderately similar to PC 52

426318 AA375125 Hs 147112 Homo sapiens cDNA FU22322 fi SS,TM,EPH_lbd,pkιnase,fn3 51

416470 N90464 Hs 303023 beta tubulin 1, class VI SS.tubulm.SS 51

432022 AL162042 Hs 272348 Homo sapiens mRNA, cDNA DKFZp7 51

457579 AB030816 Hs 36761 HRAS like suppressor TM 51

438484 AW021671 Hs 293330 ESTs, Weakly similar to p40 [H 51

422802 NM.004278 Hs 27008 phosphatidylmositol glycan, c DUF158,ank 51

401724 C16001374 gιl6755086|reflNP 03 TM,PLAT,SS 51

438670 AI275803 Hs 123428 ESTs 51

414757 U46922 Hs 77252 fragile histidine tπad gene HIT 51

425098 AW295349 Hs8038 ESTs SSJM 51

431896 AW297844 Hs 101428 ESTs SS 51

416732 H81066 Hs 285017 hypothetical protein FU21799 SS 51

404571 NM.015902* Homo sapiens proges HECT,zf-UBR1,PABP 51

433675 AW977653 Hs 75319 πboπucleotide reductase M2 po SS 51

426358 AA376438 gb EST88856 HSC172cells II Ho TM 51

456767 AI086412 Hs 129064 Homosapiens chromosome 19, co SS,TM,trypsιn,kπngle,UPA 51

412915 AW087727 Hs 74823 NM.004541 Homo sapiens NADH de 51

443553 AL040535 Hs 9573 ATP-binding cassette, sub-fami ABC.tran.SS 51

415886 Z42737 gb HSC0SE081 normalized infant SS 51

401674 C16001417* gι|7500345|pιr||T21 FAD-oxιdase_C,FAD_bιndιng 51

424266 AA337810 Hs 149152 ESTs, Weakly similar to RHOP M 51

455035 AW851734 gb MR2-CT0222-011199 007-e10 C 51

408567 S72921 ciliary neurolraphic fxtor CNTF 51

436616 AW799109 Hs 226755 ESTs 14-3-3 51

409078 AW327515 ESTs 51

447976 AW972653 Hs 293691 ESTs, Highly similar to CR2 HU 51

457720 AA992835 Hs 186776 ESTs 51

400528 NM.020975* Homo sapiens ret pr cadhenn,pkmase,SS 51

407757 BE048414 Hs 165215 hypothetical protein MGC5395 SS,EF1G_domaιn,GST_C,GST_ 51

452446 AA086123 Hs 297856 ESTs rrm,NTF2 51

450807 AI739262 gb wι17b08 x1 NCI CGAP_Co16 Ho 51

432540 AI821517 Hs 105866 ESTs SSJM 51

449324 AI638706 ESTs, Weakly similar to A47582 51

426434 M17755 Hs 2041 thyroid peroxidase EGF,sushι,An_peroxιdase,p 51

407652 W27953 Hs 292911 ESTs, Highly similar to S60712 Tropoπm 51

443952 AI149106 ESTs SS.pkinase 51

448869 AI792798 Hs 12496 ESTs, Weakly similarto ALU4.H SSJM 51 422837 U25441 Hs 121478 dopamme receptor D3 7tm 1,SS,TM,7tm 1 51

407143 C14076 Hs 332329 EST SSJM 51

442296 NM.007275 Hs 8186 lung cancer candidate SS,TM,Glyco_hydro_56,Glyc 51

407722 BE252241 Hs 38041 pyπdoxal (pyπdoxine, vitamin pffcB.SS 51

427336 NM 005658 Hs 2134 TNF receptor-associated fxtor MATH,SS,MATH,A2M N,A2M,NT 5 1

447960 AW954377 Hs 26412 πng finger protein 26 SS,TM,Cbl N.Cbl N2,Cbl N3 51

400863 C11002296 gι|11692557|gb|AAG39 SSJM 51

409034 AI684149 Hs 172035 hypothetical protein similar t SS 51

421696 AF035306 Hs 106890 Homo sapiens clone 23771 mRNA 5 1

427587 BE348244 Hs 284239 ESTs, Weakly similar to I78885 SS.UDPGT 51

407204 R41933 Hs 140237 ESTs, Weakly similar to ALU1.H SS,hιstone,hιstone 51

454219 X75042 Hs 44313 v-rel avian reticuloendothelio RHD.TIG 51

430513 AJ012008 Hs 241586 G6C protein SS,TM,GST_C,abhydrolase 5 1

435902 AA701867 Hs 297726 ESTs 5 1

442743 AI801351 Hs 302110 ESTs, Weakly similar to MUC2 H SS,fibπnogeπ_C,Rhodanese 5 1

454923 AW897236 gb CM0-NN0057-150400-335-c06 N SS.Caldesmon 5 1

440518 AA888046 Hs 233235 ESTs SSJM 5 1

448237 AI471790 Hs 309386 ESTs TM,Rιbosomal_S7 5 1

428924 AI016405 Hs 98959 ESTs, Weakly similar to JC5314 SSJMJectin c 51

412081 Z24895 Hs 293818 gb HSB67F122 STRATAGENE Human SS,TM,SQS_PSY,GATA 51

437141 BE304917 Hs 31097 hypothetical protein FU21478 SS,TM,Glycos_transf_4 51

421658 X84048 Hs 301760 frequenin (Drosophila) homolog efhand 5 1

423467 AK000214 Hs 129014 hypothetical protein FU20207 SS,TM,GDPD,SS,TM,SH3,PDZ, 50

417151 AA194055 Hs 293858 ESTs PH 50

408307 AI761786 Hs 204674 ESTs Armadillo.seg 50

404752 NM.024778 Homo sapiens hypothe 50

453126 AA032155 Hs 61622 ESTs 50

413983 BE348384 Hs 279194 ESTs 50

405366 NM 003371* Homo sapiens vav 2 SS 50

412425 AW949156 gb QV4-FT0005-110500-205-b06 F 50

437036 AI571514 Hs 133022 ESTs SS,TM,Glycos_transf_2 50

448455 AI252625 Hs 269860 ESTs, Moderately similar to S6 SSJM 50

411413 BE379438 Hs 211573 heparan sulfate proteoglycan 2 igjaminm BJamimn EGF, 50

432579 AF043244 Hs 278439 nucleolar protein 3 (apoptosis CARD,SS,HSF_DNA-bιnd,E2F 50

424874 AA347951 Homo sapiens cDNA FLJ20812 fis SS 50

408023 BE018269 Hs 279688 ESTs 50

411758 AW860667 gb QV0-CT0383-210400-204-d03 C homeobox.homeobox 50

410660 AI061118 Hs 65328 Fanconi anemia, complementatio 50

427411 AA402242 ESTs 50

437018 AA889078 ESTs SSJM ERG4.ERG24 50

427029 AA397596 ESTs SS.ras 50

452047 N35953 Hs 43510 ESTs, Weakly similar to BOX B SS 50

432093 H28383 gb yl52c03 r1 Soares breast 3N Band 41.ERM 50

453099 H62087 Hs 31659 thyroid hormone receptor-assoc SS 50

441456 AI458911 Hs 127765 ESTs 50

414356 AW505085 Hs 335147 gb UI-HF-BNO-als-a-10-O-Ul rl SSJM 50

434067 H18913 Hs 124023 Homo sapiens cDNA FLJ14218 fis 50

436393 AW022213 ESTs Galactosyl_T_2 50

409227 AA806165 Hs 130323 Homo sapiens, clone IMAGE 3960 50

448680 AW245890 Hs 21753 JM5 protein WD40,SS,TM,KOW,HLH 50

439343 AF086161 Hs 114611 hypothetical protein FU11808 50

428079 AA421020 Hs 208919 ESTs SSJM.trypsin 50

421951 BE327432 Hs 109804 H1 histone family, member X 50

427204 AA405404 Hs 215725 ESTs SS.SS 50

409690 W45393 Hs 55888 xtivating transcπption fxto 50

436574 AW293527 Hs 126465 ESTs 50

457761 AW401809 Hs 4779 KIAA1150 protein SS,LIM,SS 50

435294 T84084 Hs 196008 Homo sapiens cDNA FLJ11723 fis HMG box 50

445372 N36417 Hs 144928 ESTs SS,PID,PDZ 50

44Q511 AF132959 Hs 7236 eNOS mterxtmg protein SS,TM,MAGE,Rιbosomal_S17_λ 50

424437 BE244700 Hs 147049 cut (Drosophila) like 1 (CCAAT CUT,homeobox,beta-lxtama 50

401539 NM.002675 Homo sapiens promyel zf-B box,zf-C3HC4,SS 50

417903 NM 002342 Hs 1116 lymphotoxin beta receptor (TNF TNFR c6,SS 50

442451 AI498080 Hs 129616 ESTs SS 50

450536 AI699529 gb tt17a02 x1 NCI_CGAP_GC6 Horn SS,G-alpha,arf 50

425169 AW292500 Hs 128514 ESTs SS 50

435262 AA677088 ESTs 50

444855 BE409261 Hs 12084 Tu translation elongation fxt GTP_EFTU,GTP_EFTU_D3,GTP_ 50

433507 AI817336 Hs 191791 ESTs pkinase 50

432396 AW295956 Hs 11900 hypothetical protein FU14S72 SS 50

438395 AA017514 Hs 6211 methyl-CpG binding domain prot MBD,zf-CXXC,SS,zf CXXC 50

446603 NM.014835 Hs 15519 oxysterol binding protein rela Oxysterol.BP.SS 50

400762 Target Exon 50

440133 AI056255 Hs 133349 ESTs 50

445903 AI347487 Hs 132781 class I cytokine rxeptor SSJM.EF1BD 50

412940 BE295701 Hs 819 homeo box B7 homeobox,SS,homeobox,home 50

419269 AA235838 gb zs41b04 s1 Soares_NhHMPu_S1 TM 50

TABLE 20B Pkey Unique Eos probeset identifier number CAT number Gene cluster number Accession Genbank xcession numbers Pkey CATNumber Accession

408117 1040001 AL138255 BE380045 AA047314 D82381 T18585 H64978 T10798

408215 10478.1 BE614290 AA307674 N35629 AA338538 AI193603 AA781096 AI680061 AI613258 AW276647 BE221263 AI348910 AI985031 A1090078 AI359617

AA666391 AI160210 AI446461 AI355345 AI343638 AI343640 AI275091 M78746 AW262795 AW250002 AA503756 AI934519 AW272086 N26520

AA626639

408270 10499801 AW177805AW177895AW177816 AW177901 BE141597 BE141584AW177822AW177818AW177899

408294 10505531 BE141732 U75823 BE141331 AW178416 AW178430 BE141343 BE141298 BE141702 BE141285

408567 106631 S72921 NM.000614 X55889 X60542 X60477

409078 10987561 AW327515 AW327774 AW327571

409164 1104211 AA706639 AA064707 AL036920 AI651598

409679 1147871 BE250521 AA076837 BE249870 AA984291 AW502442AW501551 AI221491 AA194239 D63046 AA193426 AA773243 AA193293

409832 1155641 AW963293 AI866310AA077791 AA362540

410445 1203742 AA199830 A1143895 AW961629 AA322482

410471 12047211 T88872AW749857

410895 1226051.1 AW809679 AW809678 AW810113 AW810182 AW809900 AW809851 AW810110 AW810228 AW810342 AW810181 AW809632 AW809745

AW810372 AW809681 AW809792 AW809806 AW810452 AW809675 AW809964 AW810033 AW810111 AW809846 AW809847 AW809717

411219 1236055.1 AW832917 AW832913 AW832906 AW832788 AW832915 AW832776

411298 1237955.1 AW835858 AW835836 AW835823 AW835834 AW835831 AW835832 AW835843 AW835816 AW835833 AW835815 AW835849 AW835835

AW835848 AW835851 AW835852 AW835862 AW835855 AW835825 AW835847 AW835838

411426 12455151 BE141714 AW845993 AW845989

411456 12467061 AW847588 AW847716 AW847664 AW847592

411490 12474261 R39474AW848420 R76943

411605 1251232 AW006831 AA678298 R12579 W86152 AI123683 AA699780 AI672156 BE092587 AA094230 AI633815 AA526153 W86151

411758 1256751 1 AW860667 AW860665

412091 12765641 R06185 AW891805 AW901892 AW901895

412122 1278382 AW852707 N57282 AA725075 AI703492 AW612137 AI696372 AI879394 AI653605 W26914

412128 12787261 AW894709 N78140

412173 12808701 T71071 AW902279 AW897608

412425 12937261 AW949156 AW949003 AW949008

412452 129707.1 AA215731 N48523 AA307559 AA130794 BE296746 BE378396 AA190411 AI904194 AA311805 AI356291 AA446714 AI818924 AI609152

AW771476 BE298184 AA295023 AA130708 AI078381 AA114156 AI198283 AA215665 AI201085 AI694848 AI077572 AA102778 AW016425

AI923123 AA577072 AI671

412777 1326721 AI335773 AI288496 AA120880

412934 13373891 BE011437 BE011402 BE011395 BE011428 BE011407 BE011421 BE011406

413272 135718.1 AA127923 AA127846 AA534131 N53566 AA533669 AW511251 AI174441 AA127875 AI685293 AA127913 N72525 A 770386 N69010AW070312

H80275 H80289 AA972923

413534 1375357.1 BE146961 BE146780 BE146788 BE146967 BE146774 BE146963 BE146907

413564 13767221 BE260120 BE148538

414347 14374061 BE275835 BE390063 BE388764 BE409101

414371 14388.8 AI905865 BE294801 BE562308 BE297957 AW157051 AI815883 AW162529 BE439610 AW157225 AW157210 AW162675 AW161998 AI816168

AW162599 AI816004 AI815820 AW162158 AW162339 M17733 AW157639 AI879416 BE258811 AW157436 AW162433 AW161633 AW162155

AW157410 AW157269AW162

414391 14419211 BE409872 BE281460

414413 14436961 BE294877 BE294759

414593 14649091 BE386764 BE387560

414944 15094801 C15044 D80943 C15696

415126 15235061 D60945 D61346 D81568 D80539

415611 15405551 T26376 F12852 T75058

415886 15604111 Z42737 T08986 H07956

415958 1563222.1 H10942 Z42911 R60453

416233 1580101 AA176633 AW961842AA309418

416597 16030811 H66891 R98149 H68467

417739 16961981 Z43995 R12357 R34740

418184 1727441 AA367375 AA486701 BE152479 BE152800 AW816961 AA214097

418304 1736582 AA215702 AA368006 AA215703 BE066555 BE006876

419269 1834441 AA235838 BE180775

419516 1855331 H82550 N43802 AA243820 AL040762 N24315 U66692

420530 19446J AI218431 AA432232 A 183040 X86012 AA868831 AI191788 AA912999 AI204297 AI205744 AI218259 AA428596 AA993742 AA703660 AI018669

AA879431

421879 2086491 AW959607 AA299654 AA579966

423790 2320311 BE152393 AA330984 BE073904

424874 2445231 AA347951 AI688463AA883123

426221 26281.1 AB007881 U32581 AW131202 AW995994 W31964 N24261 AI033045 H98694 AW364848 AI222031 AA907216 AI215730 AA776981 AW473826

W31373

426358 2655041 AA376438 AA376324 AW963848 AW834782

426576 2693781 AA381720 AA382040 AW963564

427029 2745441 AA397596 AI198827 AA435832

427326 2772291 AI287878 AI804160 AA400787

427411 2784741 AA402242 AA813659 AI150316 AA412054

428092 2869201 AW879141 AA421182 AI734104 AI733923 AA430600

428304 2896031 AI743177 AA425743 AI804283 AI743189

428948 29737.1 BE514362 AI879343 BE272870 BE616390 AW163444 AW161588 AW378754 AW238803 BE267205 BE047746 BE207213 BE312782 BE266301

BE266413 BE278348 BE280885 BE278833 BE281417 BE407786 BE378176 BE392818 AW377597 BE395951 BE393978 AW327483 BE394175

BE385795 BE275663 BE3

429398 3039541 AA452239 AI262173 AI925886 AI469041 H96628 AI768463 AI671422 AI915624 AA766891 AA521087 AA814103 AW993151 AW005927

430168 3139271 AW968343 AA468507 AI478223 AW513008 AI762122 AI554512 AA862642 AA468976

431082 3277101 AA491600 AA491645 AI920986

431161 3287131 AA493591 AA829120AA533792

431424 3331101 AI222969 AA806560 AA504839 AA805261

431627 335811 AW609720 AW609735 AA082767 N88831 R23418 N55837 BE549484 AW816584 AW816947 AW816897

432093 3412831 H28383 AW972670 H28359 AA525808

432945 3565891 AL043683 AA570698 AA907496 AL043682 AW362288

433168 3602351 A1085436 AA579438 AA579002

433357 36402.1 T05639 AF024702 434315 3834021 AW196608 AA884617 AA758108 AI126321 AA629291 AW196549 AI208031

434743 3925.1 AI363410 AI356019 H00141 T78748 AL049365 AL079911 AI750972 Z42602 AW452523 AI223826 AA215407 AI633829 AA292122 N42783

AW505595 AF086096 N90340 N63271 AA131836 AW607273 AA527132 T32315 AA421961 T34951 AW966080 M78807 N31947 AA521151

AA278866 AA044784AA700

434796 3934001 AA812046 AW974514 AA764999 AA649302

435186 4021431 AL119470 AA669492 AI628351 AI263835 AL119498

435262 4036051 AA677088 AI022246 AA677107

435339 4044851 AI358300AI762981 AA678073 AA988621

436094 4144441 AI798701 AW008826 AA704731

436389 41894.1 AI811706 AW297940 AJ227887 AA875850 AA228803 A1610234 AI921618 AI768606 N37039 AA081104 BE172693 D56503 Z28585 T95651

AA292389 AA293502 N28751

436393 419031 AW022213 AI274032 AJ227898 AI160412 AI084451

437018 4313331 AA889078 AA907263 AA742199

437050 4322101 AA766420 AA743319 AW976442

437215 43473 ϊ AL117488 AL044479

437662 4403741 AA765387 AA832241 AI222134 AI216405 AI685043

437834 443674.1 AA769294 AW749299 AW749302 AW749295 AW749304 AW749293 AW749298 AW749294 AW749288 AW749291 AW749297 AW749292

AW749296 AW749289 AW749287 BE535498

438118 4502931 AW753311 AW663081 AA778411

438723 463921 M34429 M34431 M34432 M25802 AW938720

439034 468021 AF075083 H52291 H52528

439150 469191 AF086006 H64722 H65212 H66282

439469 472741 W69836 AF086287 W69657

440317 491871 BE561888 BE560615 BE562102

440546 4969762 AI491994 AW139809 AA889258 AI700895

441358 5154681 AW173212 AA983948 AI080705 AA931334

441523 5190491 AW514263 AI567908 AI299828 AI299043 N51706 AA936483

441794 5262891 AW197794 AW195867 AW197787 AA968466

442146 5339721 R52599 T65201 F11984 F13186 AA977679 T77028 H 12167

442318 5385841 AI792199 AI733491 AA991378

442472 543371.1 AW806859 AW806852 AF049582

442780 5514051 AI017521 AI017613 AW511133

442893 5539871 H78133 H90849 A1023482

443952 5865241 AI149106 AI500318 AI334156 AI093029 AI765679 AI769652 AI167308 AI128885

444406 6050041 AI147237AI800517

445099 6297851 BE163341 AI207756 BE171477

445625 645581 BE246743 AA436942 AW024744 AW242177 AA975476 AW385185 R07536 R73462 AV654529 T57442 AI399986 R50073 R48743 AI769689

AI863005 AA317806 AI678000 AW189963 AI986207 AW471273 R73463 AI335104 AI590161 AI469257 AI954604 H21954 T25141 AA856793

R50074 AI708253 AI2

445631 6457.1 AK001822 AW860325 AA335296 AW965531 AW130957 AW193951 AI347975 AW081323 AW662527 AI343924 AI380749 AA938153 T66966

AI655000 AW418837 AI380485 AA410698 AI520726 BE501355 AI637925 AW779200 AI524755 AW593995 AI336927 AI336928 AI357036 R60592

H19058 R11124 T1

445837 6520681 AI261700 AI793196 AI469160 A1793007 446780 692897.1 R31107 AI341136 AI653198 H04953 446790 693032.1 AW452105 AI341280 AI917445 447045 70510.1 AW392394AW579531 AW382131 AA010316 BE146145 AW579562AW579577 BE146152 BE146040 BE145972 BE146099AW003280 AA868470

BE146306 T85009 AI087294 BE146299 BE146319 BE146307 W44912 AI703134 AW026017 BE382873 AA903733 AI655933 BE551223 AA847664

AW173582AW57240

447128 70934 1 AI271898 BE048502 AI452509 AI244810 X84721 AI858001 AI553937 AA149853 H00719 AI765259 AW973696 F25787 F35749 AI568815

AW015380 AA554539 C00201 AA961610AW059537 R77127

447904 7419131 AW206303 AW207644 AI765705

448330 7586901 AL036449 AW016705 AI492482

448993 79225.1 AI471630 BE540637 BE265481 AW407710 BE513882 BE546739 AA053597 BE140503 BE218514 AW956702 AI656234 AI636283 AI567265

AW340858 BE207794 AA053085 R69173 AA292343 AA454908 AA293504 AI659741 AI927478 AA399460 AI760441 AA346416 BE047245

AA730380 AA394063 AA454

449324 8048061 AI638706 BE550292 R11026

449495 8083451 AI652833 A1695904 AW888916

450251 8299871 BE080483 8E080416 AI689298

450536 8378481 AI699529 BE161564 BE077251

450807 8475911 AI739262 R28418

451045 856731 AA215672 AI696628 AA013335 H86334 AA017006

451752 8835.1 AB032997 N74056 BE467119 AW237035 AI141678 AA934774 AW978722 AI761408 H09497 AI934521 AA716567 H62600 AI479668 Z40632

AA832081 Z44858 H09496 BE395335 AW295901 BE465977 AI621269 BE465983 M79058 H62533 AA325444

452113 8996641 AI859393 BE177742

453413 9662691 AJ003294 AJ003315 AJ003293

453829 9827311 AL138200 T71830T71828

453904 9865811 AW003821 AW027475AW025661

454438 120132.1 AA224053 AA114150 AA214275 AA224027 T58431 AA211908 AA669657 AA199744 AA630511 AA164864 T58463 AA214394 AA161378

AA161386 AA205211 AA167824 AA084940 AA223625 AA191190 AA309486 AW961804

454453 12068271 AW752781 BE143749 AW752727 AW752559 AW752578 AW752584 R45742

454577 1225673.1 AW809272 AW809169 AW809179 AW809192 AW809166 AW809172 AW809191 AW809165 AW809197 AW809181 AW809237 AW809226

AW809250 AW809199 AW809259 AW809239 AW808273 AW808270 AW808147 AW809188 AW809245

454682 12289761 AW816029AW813292AW816156 AW813333 AW816159 AW813302 AW813344AW813172

454718 12305321 AW815144 AW815150 AW861007

454756 12336461 AW819273 AW819283 AW819287AW819281 AW819274AW819282AW819277 AW819286

454923 12450241 AW897236 AW845406

455035 12497621 AW851734AW851676AW851693 AW851713 AW851722AW851616 AW851731 AW851618 AW851648 AW852215

455274 12722121 BE151622 BE151636 AW885648

455286 12735761 BE144384 AW887474 AW887403 BE144386

455557 13259741 AW995839 AW995907

455604 1337197.1 BE011183 BE011170 BE011333 BE011188BE011181 BE011324 BE011161 BE011169

455679 13499141 BE066529 BE066274 BE066390 BE066356 BE066419 BE066345 BE066298 BE066292 BE066359

455778 13645061 BE088746 BE088802 BE088755 BE088876 BE088947 BE088881 BE088952

455885 13803851 BE153524 BE.153576 BE153583 456487 19270.1 AF064804 AA320309 N89343 AA564588 AF069734 AA349248 AW964366 T98541 AW511100 T98542AW070452AA013172 AI767005 T321 0

W05727 T30969 T30970 N74883 AA903211 AI392796 AI434622 AA829283 457892 432926.1 AA744389 AA744270 AA744284 AA744299 AA745380 AA744337 AA846905 AA847698 457978 448900.1 AA776638 BE439540 458198 504834.1 AI286100AA952934AA918305

458644 670856.1 AW270149AW664628AI285912

TABLE 20C

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham I et al " refers to the publication entitled The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495 Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons

Pkey Ref Strand NLposition

400460 8389428 Plus 35559-36295

400500 9796136 Minus 120238-120495

400528 6981824 Plus 472381-472528,474170-474277,475328475542,475878476000

400668 8118719 Plus 121756-122043

400748 8119063 Plus 84237-84398

400762 8131616 Plus 7235-7605

400772 8131629 Minus 34896-35021,41078-41197

400833 8705148 Minus 187599-188138

400863 9798616 Plus 21575-22330

400906 9966290 Plus 112863-112989,120162-120286

400923 7637836 Minus 94518-94659 '

401121 8570296 Plus 57211-57525

401180 9438648 Minus 150981-152128

401203 9743387 Minus 172961-173056,173868-173928

401210 7712287 Plus 166969-167133,169760-169877,171563-171733

401215 9858408 Plus 103739-103919

401264 9797154 Plus 130810-130927,133367-133504

401278 9799936 Plus 98428-98573

401349 9930791 Plus 72440-73030

401402 7710964 Plus 75730-76077

401488 7341775 Plus 54523-54686,55364-55451,55737-55846,58047-58175,58261-58356

401507 7534110 Plus 71055-71259

401539 8072433 Minus 62028-62608

401553 8099284 Minus 83990-84161

401594 7230963 Plus 7997-8170

401674 7689903 Plus 138786-138927,139157-139298,139440-139599,139960-140159

401677 9965537 Minus 62856-63086,63603-63884

401722 7656694 Plus 143861-144054

401724 7656694 Plus 150063-150241

401822 6730824 Plus 88400-89959

401885 8140731 Plus 148234-148321,150365-150559

401935 3808091 Plus 46329-46473

401938 6102666 Plus 151891-152032

401984 4454511 Plus 103825-104024

402189 8576043 Minus 128318-129601

402197 8576113 Plus 199466-199585

402285 2689079 Minus 92386-92634

402365 9454515 Minus 70928-71185

402445 9796614 Plus 90925-91064,91172-91331

402501 9797862 Plus 8601-8876

402545 9838114 Minus 48547-48678,50604-50737,51384-51467

402651 7960391 Plus 174215-174380

402916 7406502 Minus 361474,541-687

403003 5441423 Minus 79403-79560,79712-80021

403128 7331426 Plus 122884-123018,123134-123283,123372-123695,123779-123940,124059-124256

403672 7283286 Minus 96600-96881,96951-97280,97393-97594

403748 7658423 Minus 129503-130344

403885 7710403 Minus 53259-53524

403938 7711795 Plus 48636-48822

404001 8655948 Minus 137995-138317

404066 3367505 Minus 71040-71288

404149 7534008 Plus 121831-121951,124044-124150

404199 6010176 Minus 1669-2740

404311 8570412 Minus 149189-149303

404333 9802821 Minus 137948-138024,138111-138300

404365 9864977 Plus 50151-50319,50859-51098

404430 7407979 Plus 4292143109

404438 6984205 Plus 63413-63553

404571 7249169 Minus 112450-112648

404596 9958262 Minus 104807-105043

404676 9797204 Minus 56167-56342,58066-58189,58891-59048,60452-60628

404710 9801097 Minus 45190-45339,4750947622,4813748264,4880548946,50073-50345,51467-51588

404752 7109522 Minus 120168-120326

404807 4165210 Minus 124246-124422

404956 7387343 Plus 55883-56203

405085 8072509 Minus 4404544230

405113 8096927 Plus 170073-170894

405143 9438278 Plus 5894-5983,7355-7427

405159 9966252 Plus 79659-79804 405211 6692345 Minus 31340-32609

405247 7249301 Minus 65578-65778,68088 68234

405346 2981263 Plus 101982-102171

405366 2182280 Plus 22478-22632

405371 2078469 Minus 4765747766,48461-48596

405375 1552539 Plus 11646-12050,12207-12485

405376 1552533 Plus 28875-29099

405473 8439781 Plus 153074-153343,154501-154598,156879-156999,158863-159051,159910-160053,161109-161229,163035-163131,165163- 165259,165868-166003,167375-167552,169252-169364,171127-171281

405474 8439781 Plus 172005-172175

405557 1621108 Plus 39883-40047

405637 6289229 Plus 189852-189978

405770 2735037 Plus 61057-62075

405928 7717155 Minus 2923-3209

405931 6758795 Minus 148233-148705

405939 6758795 Plus 170500-170654

406109 9127147 Minus 58328-58485

406230 4760409 Plus 71716-72515

406284 7549620 Plus 74002-74199

406299 5686278 Minus 35655-36119

406301 8575868 Plus 57291-57494

406373 9256130 Plus 188922-189152

406495 7711328 Minus 174661-174978

406575 7711679 Plus 142034-142473

Table 21 A lists about 933 genes up-regulated in ovanan cancer compared to normal adult tissues that are likely to encode extracellular or cell-surface proteins These were selxted as for Table 20A, except that the ratio of "average" ovanan cancer to "average" normal adult tissues was greater than or equal to 30, the "average" ovanan cancer level was set to the 96th percentile value amongst vaπous ovanan cancer specimens, the "average" normal adult tissue level was set to the 75th percentile value amongst vanou non- malignant tissues, the "average" ovarian cancer value was greater than or equal to 400 units (this selxts for the most abundant of the up regulated genes), and the predicted protein contained a structural domain that is indicative of extracellular localization (e g , ig, frι3, efg, 7tm domains, signal sequences, transmembrane domains) The predicted protein domains are noted

TABLE 21 A Pkey Unique Eos probeset identifier number

ExAccn Exemplar Accession number, Genbank accession number

UG ID Unigene number

Title UniGene gene title

Pred Protein Dom Predicted protein domain R1 Ratio of tumor to normal body tissue

Pkey ExAccn UG ID Title Pred Protein Dom R1

407223 H96850 gb yw03b12 s1 Soares melanocyt SS,TM,SS,TM,DDOST_48kD 58 9

421296 NM 002666 Hs 103253 peπlipin peπlipiπ.SS 476

430281 AI878842 Hs 237924 CGI-69 protein mito.carr.SSJM 467

410418 D31382 Hs 63325 transmembrane protease, serine SS,TM,ldLrecept_a,trypsι 41 0

431773 BE409442 Hs 268557 pleckstπn homology-like domai PH,SS,LIM,Troponιn 37 1

428758 AA433988 Hs 98502 CA125 antigen, mucm 16 SS 356

438424 AI912498 Hs 25895 hypothetical protein FLJ14996 SSJM 35 3

450461 BE408081 Hs 46736 hypothetical protein FU23476 SS 344

437897 AA770561 Hs 146170 hypothetical protein FLJ22969 SS,TM,zf DHHC 33 9

452554 AW452434 Hs 58006 ESTs, Weakly similar to ALU5.H SS.PAS.HLH 325

422310 AA316622 Hs 98370 cytochrome P450, subfamily IIS SS,TM,pkιπase,fn3,ιg 305

452849 AF044924 Hs 30792 hook2 protein bZIP,SS AhpC-TSA 296

407722 BE252241 Hs 38041 pyπdoxal (pyπdoxine, vitamin pfkB.SS 282

416819 U77735 Hs 80205 pιm-2 oncogene pkinase,SS,TM,OTU,K_tetra 279

430397 AI924533 Hs 105607 bicarbonate transporter relate HC03_cotransp,SS,TM 277

427725 U66839 Hs 180533 mitogen-activated protein kma pkmase 275

454017 AW023617 Hs 347130 hypothetical protein FLJ22709 SS,TM,myosιn_head,RA,DAG_ 272

445434 BE391690 Hs 9265 hypothetical protein FU20917 SS,PWWP,Exonuclease,lιpoc 268

452399 BE513301 Hs 29344 hypothetical protein, clone 24 SS.peπlipm 265

419451 AI907117 Hs 90535 syntaxin binding protein 2 Sec1,SS,TM 251

424420 BE614743 Hs 146688 prostaglandin E synthase MAPEG,SS,TM,MAPEG 25 1

407893 BE408359 Hs 43621 Homo sapiens, Similar to hypot SS,SS,arf,ras,fn3,ras 250

412674 X04106 Hs 74451 calpa 4, small subunit (30K) efhand,SS,CAP_GLY 244

430023 AA158243 Hs 227729 FK506-bmdιng protein 2 (13kD) SS,FKBP,SS,PDGF,C2,PI-PLC 243

444672 Z95636 Hs 11669 laminin, alpha 5 lamιnιn_EGF,lamιnιn_G,EGF 240

413726 AJ278465 Hs 75510 annexιn A11 annexιn,SS,annexιn 23 1

438951 U51336 Hs 6453 iπositol 1,3,4-tπphosphate 5/ SS,oxιdored_nιtro,SS 230

429099 BE439952 Hs 196177 phosphorylase kinase, gamma 2 pkιnase,SS,SNF2_N,helιcas 23 0

422645 L40027 Hs 118890 glycogen synthase kinase 3 alp pkιπase,SS,Ets 224

427899 AA829286 Hs 332053 serum amyloid A1 SS,SAAj)roteιns,SS,SAA_pr 222

407117 AA146625 gb zo71c07 s1 Stratagene pancr SS 21 3

402916 ENSP00000202587* Bicarbonate t HC03_cotransp,SS 208

425760 D17629 Hs 159479 galxtosamme (N xetyI)-6 sul Sulfatase.SSJM 207

422098 H03117 Hs 111497 similar to mouse neuronal prot TM 206

442232 AI357813 Hs 337460 ESTs, Weakly simila to A47582 SS,TM,TGFb_propeptιde,TGF 201

453157 AF077036 Hs 31989 DKFZP586G1722 protein SSJropomyosin 200

422179 AF091619 Hs 112667 dynem, axonemal, intermediate WD40.SS 200

419444 NM.002496 Hs 90443 Target CAT fer4,SS,TM,V_ATPase_sub_a 195

416893 AA455588 Hs 62406 hypothetical protein FU22573 SS,rrm,SS 192

434030 AW162336 Hs 3709 low molecular mass ubiquiπoπe- SS 19 1

411813 NM 014931 Hs 72172 KIAA1115 protein SS,TM,Y_phosphatase 189

422305 AI928242 Hs 293438 ESTs, Highly similar to AF1984 SS 18 8 419167 AI589535 Hs 94875 ESTs, Weakly similar to A35363 SS 186

406663 U24683 immunoglobulin heavy constant SS 185

429712 AW245825 Hs 211914 ENSP00000233627* NADH-ubiquino oxιdored_q6,SS,TM,rrm 185

425848 BE242709 Hs 159637 valyl tRNA synthetase 2 GST_C,GST_N,Tropomyosιn,S 184

447151 AI022813 Hs 92679 Homo sapiens clone CDABP0014 m SS,TM,LRR,amιnotraπ_1_2 184

413343 BE392026 Hs 334346 hypothetical protein MGC13045 SS.DnaJ 182

450029 AW073380 Hs 267963 hypothetical protein FU 10535 SS,Pyπdox_oxιdase,zf-C2H 177

427721 AI582843 Hs 180455 RAD23 (S cerevisiae) homolog ubιquιtιn,UBA,ιntegππ B, 176

443780 NM 012068 Hs 9754 xtivatmg transcπptioπ fxto bZIP,NTP_traπsf_2,SS,TBC 172

421612 AF161254 Hs 106196 8D6 antigen Idl recepLa,SS,TM 171

444607 AW405635 Hs 293687 ESTs SS,PI-PLC-X,PH,PI-PLC-Y,C 167

406621 X57809 Hs 181125 immunoglobulin lambda locus SS 166

443496 AJ006973 Hs 9482 target of mybl (chicken) homol VHS,GAT,TM,Heme oxygenase 166

440104 AA132838 Hs 239894 hypothetical protein MGC2803 SS.DS 163

427640 AF058293 Hs 180015 D-dopxhrome tautomerase MIF.Iate protein L2,SS,GS 162

445625 BE246743 hypothetical protein FU22635 SSJM 161

427461 AA531527 Hs 332040 hypothetical protein MGC13010 SS,TM,ACAT,LRR 159

423366 Z80345 Hs 127610 xyl-Coenzyme A dehydrogenase, Acyl-CoA_dh,Acyl-CoA dh M 157

409017 T86957 Hs 272299 hypothetical protein RP4-622L5 SSJM 156

428167 AA770021 Hs 16332 ESTs SS,ιg,fn3 155

420029 BE258876 Hs 94446 polyamine-modulated fxtor 1 aldo keLred,SS,TM,gla 155

400460 C11002253* gι|129091 [sp[P23267 SS,TM,SCAN,zf-C2H2,KRAB 154

407767 W15398 Hs 38628 hypothetical protein SS,zf-CCCH 154

406918 M88357 gb Homo sapiens DNA-bindmg pr zf-C2H2,SS 154

435158 AW663317 Hs 65588 JJAZ associated protein 1 rrm, SS.mn 153

407619 AL050341 Hs 37165 collagen, type IX, alpha 2 SS,Collagen,SS,Collagen 153

421273 AJ245416 Hs 103106 U6 snRNA-associated Sm-like pr Sm,SS,tRNA-synL1,GST_C,G 151

402365 Target Exon SS,SS,TM,ιg 149

450503 R35917 Hs 301338 hypothetical protein FLJ12587 SS 148

427502 AI811865 Hs 7133 Homo sapiens, clone IMAGE 3161 SSJM.ABC tran.GlycoJran 146

432872 AI908984 Hs 279623 selenoprotein X, 1 DUF25,SS,Rιbosomal L3.PDZ 145

439233 AA831893 Hs 292767 hypothetical protein FU23109 zf C3HC4,TM,Sulfale trans 145

416897 M78146 Hs 324700 hypothetical protein MGC2663 SS 143

447304 Z98883 Hs 18079 phosphatidylinositol glycan, c SS.Peptidase C2 142

431543 AW969619 Hs 259768 adenylate cyclase 1 (brain) TM 140

447544 AA401573 Hs 288284 hypothetical protein FU22378 SSJM 140

417595 AA424317 Hs 6259 KIAA1698 protein SS,TM,Glycc_hydro_31,Glyc 138

436127 W94824 Hs 11565 RIKEN cDNA 2010100012 gene Corona_7,SS,TM 138

412623 R28898 Hs 74170 metallothioπem 1E (functional SS,TM,metalthιo,DEAD,meta 137

448133 AA723157 Hs 73769 folate receptor 1 (adult) Folate rec.SS 135

453367 AW732847 Hs 70573 PKCI-1-related HIT protein SSJM 135

431462 AW583672 Hs 256311 granm like neuroendocπne pep SS 132

408724 AI685842 Hs 294143 ESTs, Weakly similar to T22914 SS,pkιnase,tubulιn 132

423464 NM.016240 Hs 128856 CSR1 protein Collagen.SS 131

428539 AW410063 Hs 184877 solute earner family 25 (mito mito carr,SS,TM,profilιn, 130

436014 AF281134 Hs 283741 exosome component Rrp46 RNase PH,RNase_PH_C,SS,TG 129

438857 AI627912 Hs 130783 Forssman synthetase SS,RA,RasGEF,RasGEFN 128

444410 BE387360 Hs 33719 ESTs, Moderately similar to S6 SS 128

427527 AI809057 Hs 153261 immunoglobulin heavy constant SS,TM,ιg 126

430168 AW968343 DKFZP434I1735 protein SS,TM,efhand,efhand 125

437543 H16443 Hs 7117 glutamate receptor, lonofropic SS,TM,lιg chan,ANF_recept 124

413711 AW291765 Hs 75486 heat shock transcπptioπ fxto NA,SS,E2F_TDP 123

422625 AW504698 Hs 155976 cullm 4B SS,SS,Cullm,Cullιn 122

443136 NM.001440 Hs 9018 exostoses (multiple) like 3 Exostosm.SSJM 12 1

407143 C14076 Hs 332329 EST SSJM 121

424707 BE061914 Hs 10844 Homo sapiens cDNA FU14476 fis SS,SS,TM,Sema 121

425251 Z22521 Hs 155342 protein kinase C, delta pkmase.DAG PE-bιnd,pkιna 120

427336 NM.005658 Hs 2134 TNF receptor-associated fxtor MATH,SS,MATH,A2M N.A2M.NT 120

421572 AA531607 hypothetical protein FU22678 SS,TM,TGF-beta,ASC 120

447946 AI566164 Hs 165827 ESTs SS.PTN MK,7tm 1,DAGKc,DAG 11 9

425954 AK000633 Hs 164476 hypothetical protein FU20626 SCAN,zf-C2H2,KRAB,SS,KRAB 11 7

427273 AW139032 Hs 107376 hypothetical protein DKFZp434N SS.SSJM 11 7

427397 AI929685 Hs 177656 caimodulin 1 (phosphorylase ki efhand,RrnaAD,SS,eftιaπd 11 7

424415 NM 001975 Hs 146580 enolase 2, (gamma, neuronal) enolase,SS,Afrophιπ-1,Afr 11 7

417852 AJ250562 Hs 82749 transmembrane 4 superfamily me fransmembrane4,SS,TM 11 6

447451 AI379925 Hs 207525 ESTs SS,pkιnase,PH,pkιnase C 11 5

410397 AF217517 Hs 63042 DKFZp564J157 protein SS,homeobox,UPF0160,DUF23 11 4

430354 AA954810 Hs 239784 human homolog of Drosophila Sc SS,TM,ιg 11 3

419390 AI701162 Hs 90207 hypothetical protein MGC11138 SS,TM,PMP22_Claudιn,PMP22 11 3

422682 W05238 Hs 94316 ESTs, Weakly similar to T31613 SS,TM,DEAD,helιcase C.Lam 11 3

422178 AL122083 Hs 112645 Homo sapiens mRNA, cDNA DKFZp4 SSJM 11 2

450122 BE313765 Hs 343443 ESTs, Weakly similar to I38022 SSJM.Y phosphatase,LON,A 11 1

453968 AA847843 Hs 62711 High mobility group (nonhiston SS.HMG box 11 1

444744 BE394732 Hs 147562 ESTs SS 10 9

423220 BE394920 Hs 125262 aladm WD40,TM,Actιvιπ_recp,pkιn 109

417116 Z43916 Hs 7634 hypothetical protein FU12287 SS,TM,filament,IF tail 109

406779 AA412048 Hs 279574 CGI-39 protein, cell death reg SS.SS 108

450593 AF129085 Hs 25197 STIP1 homology and U-Box conta TPR,SS,TM,Rhomboιd,lxtam 107

406837 R70292 Hs 156110 immunoglobulin kappa constant SS 107

452434 D30934 Hs 29549 C-type lectm-like receptor-1 lectin cSSJM 107

440150 AW975738 Hs 7001 Homo sapiens, clone IMAGE 3940 SS,TM,SS,TM,Peptιdase_M22 106

418641 BE243136 Hs 86947 a disintegπn and metalloprote dιsιntegππ,Reprolysιn,Pe 106

414313 NM.004371 Hs 75887 coatomer protein complex, subu WD40,SS,WD40,Rιbosomal S2 106

420307 AW502869 Hs 66219 ESTs SSJM 106 414918 AI219207 Hs.72222 hypothetical protein FLJ 13459 SSJM.efhand 10.6

446562 BE272686 Hs.15356 hypothetical protein FU20254 hormone.SS.pfkB 10.5

419846 NM 015977 Hs.285681 Williams-Beuren syndrome chrom SS,HLH,SS,TM,WD40 10.4

453023 AW028733 Hs.31439 serine protease inhibitor, Kuπ Kunitz BPTI,SS,TM,ion fra 10.4

438800 AB037108 Hs.6418 seven transmembrane domain orp SSJM 10.3

431275 T56571 Hs.10041 ESTs SS.HLH 10.3

407241 M34516 gb:Human omega light chain pro SS,ig,PH,ig,PH 10.3

441238 AI372555 Hs.322456 hypothetical protein DKFZp761D homeobox,SS,TM,Rho_GDI,th 10.3

436325 AL390088 Hs.7393 hypothetical protein from EURO SS.Synapsin CSS 10.3

435605 AF151815 Hs.4973 hypothetical protein SS,TM,SS,TM,ABC tran.ABC 10.3

444202 AL031685 Hs.12785 KIAA0939 protein SS,TM,Na H Exchanger,ABC2 10.3

425597 U28694 Hs.158324 chemokine (C-C motif) receptor 7tm_1 10.3

415200 AL040328 Hs.78202 SWI/SNF related, matrix associ SNF2_N,helicase Cbromodo 10.2

446528 AU076640 Hs.15243 nucleolar protein 1 (120kD) Noll Nop2_Suπ,SS,SNF2_N,h 10.2

414874 D26351 Hs.77515 iπositol 1,4,5-triphosphate re TM,RYDR_ITPR,ion_fraπs,MI 10.2

423524 AF055989 Hs.129738 potassium voltage-gated chaπne ion trans.K tetra.thaumat 10.2

434552 AA639618 Hs.325116 Homo sapiens, clone MGC:2962, SS 10.2

406836 AW514501 Hs.156110 immunoglobulin kappa constant SS 10.1

420233 AA256714 Hs.194864 hypothetical protein FU22578 SS 10.1

427458 BE208364 Hs.29283 ESTs, Weakly similar to LKHU p SS,F5_F8_type_C,EGF,TGT 10.1

427672 AA356615 Hs.336916 death-associated protein 6 SS.BTB.abhydrolase 2,RasG 10.0

423218 NMJ15896 Hs.167380 BLu protein zf-MYND,SS,TM,Glyco_hydro 10.0

403028 Target Exon SS.trefoil 10.0

412790 NM 014767 Hs.74583 KIAA0275 gene product kazal.thyroglobulin 1,zf- 10.0

419823 AW271708 Hs.118918 -ESTs, Weakly similar to M20M H SSJM 10.0

433886 AA613596 Hs.28412 ESTs SS 9.9

428092 AW879141 ESTs SSJM 9.8

450493 M93718 Hs.166373 nitric oxide synthase 3 (endot flavodoxin.FAD binding.NO 9.7

420423 AA827718 Hs.88218 ESTs SS 9.7

452302 AF173867 Hs.28906 glucocorticoid modulatory elem SAND.SS 9.7

444681 AJ243937 Hs.288316 chromosome 6 open reading fram notch,EGF,ank,GoLoco,SS,T 9.7

414249 AI797994 Hs.279929 gp25L2 protein SSJM.EMP24 GP25L,SS,TM,G 9.6

424263 M77640 Hs.1757 L1 cell adhesion molecule (hyd fn3,ig,IRK,SS,TM,fn3,ig,R 9.6

438627 AI087335 Hs.123473 ESTs TM.Reticulon 9.6

407065 Y10141 gb:H.sapiens DAT1 gene, partia SNF.SSJM 9.6

441307 AW071696 Hs.209065 hypothetical protein FU14225 SSJM 9.6

409649 AA159216 Hs.55505 hypothetical protein FLJ20442 Y_phosphatase,DSPc,TM 9.6

424487 T08754 Hs.6259 KIAA1698 protein SS,SS,TM,Glyco hydro 31,G 9.5

444633 AF111713 Hs.286218 juπctioπal adhesion molecule 1 ig,SS,TM,HLH 9.4

427747 AW411425 Hs.180655 serine/threonine kinase 12 pkinase,SS,TM,synaptobrev 9.4

450437 X13956 Hs.24998 hypothetical protein MGC10471 SS 9.4

415169 W42913 Hs.78089 ATPase, vacuolar, 14 kD ATP-synLF,SS,TM,CH,Filam 9.4

400201 NM_006156*:Homo sapiens neural ubiquitin,SS,TM,Transglut 9.4

454319 AW247736 Hs.101617 ESTs, Weakly similar to T32527 SS 9.4

421680 AL031186 Hs.289106 Human DNA sequence from clone SS,SS,rrm,zf-RanBP,rrm,GA 9.4

445143 U29171 Hs.75852 casein kinase 1, delta pkinase.SS 9.4

407507 U73799 gb:Human dynxtin mRNA, partia SSJM.HC03 cotransp.CAP G 9.4

450883 NM 001348 Hs.25619 death-associated protein kinas pkinase,GTP_EFTU,EFG C.GT 9.4

411674 AW861123 gb:RC3-CT0297-120200-014-a05 C SS 9.3

414625 AA335738 Hs.76686 glutathione peroxidase 1 GSHPx,SS,ras,HLH 9.3

456950 AF111170 Hs.306165 Homo sapiens 14q32 Jagged2 gen SSJM.DSL 9.3

445333 BE537641 Hs.44278 hypothetical protein FLJ12538 SS 9.2

407204 R41933 Hs.140237 ESTs, Weakly similar to ALU1.H SS.histone.histone 9.1

412338 AA151527 Hs.69485 hypothetical protein FLJ 12436 SS,TM,TIG,Sema,PSI 9.1

439963 AW247529 Hs.6793 platelet-xtivatiπg fxtor xe PAF-AH lb,Lipase GDSL.SS, 9.1

412104 AW205197 Hs.240951 Homo sapiens, Similar to RIKEN SSJM 9.1

443553 AL040535 Hs.9573 ATP-binding cassette, sub-fami ABC fran.SS 9.1

448984 AW751955 Hs.22753 hypothetical protein FU22318 SS 9.0

418776 AI401004 Hs.88411 lymphocyte antigen 117 SS.TNFJNF 9.0

418843 AJ251016 Hs.89230 potassium intermediate/small c TM,CaMBD,SK_channel,TM 9.0

419244 AI436567 Hs.89761 ATP synthase, H transporting, ATP-synLDE,SS,rrm,Ephrin 8.9

451855 R54913 Hs.175804 ESTs SSJM.vwa 8.9

424825 AF207069 Hs.153357 procollageπ-lysiπe, 2-oxogluta ^• 20G-Fell_Oxy,Glycos_trans 8.9

447374 AF263462 Hs.18376 KIAA1319 protein SS.Myosin.tail.M 8.9

430167 Y08976 Hs.234759 FEV protein Ets.SS.crystall 8.8

409936 AK001691 Hs.57655 hypothetical protein FLJ 10829 SSJM 8.7

437926 BE383605 Hs.300816 small GTP-binding protein SSJMJPR 8.7

430037 BE409649 Hs.227789 mitogen-xtivated protein kina pkinase 8.7

424919 BE314461 Hs.153768 U3 sπoRNP-associated 55-kDa pr WD40,SS,KH-domain 8.7

414534 BE257293 Hs.76366 BCL2-antagonist of cell death SS,hormoπe_rec,zf-C4 8.7

433333 AI016521 Hs.71816 v-akt murine thymoma viral one homeobox,pkinase,PH,pkina 8.7

423228 AL137491 Hs.125511 Homo sapiens mRNA; cDNA DKFZp4 SSJM.sushi 8.7

419493 AF001212 Hs.90744 proteasome (prosome, mxropain PCI,SS,CDK5_activator 8.7

420160 AI492840 ESTs SSJM 8.6

421871 AK001416 Hs.306122 glycoprotein, synaptic 2 TM,Steroid_dh,SS 8.6

447827 U73727 Hs.19718 protein tyrosine phosphatase, Y_phosphatase,fn3,ig,MAM, 8.6

417193 AI922189 Hs.288390 hypothetical protein FU22795 SS 8.6

418678 NM.001327 Hs.167379 cancer/testis antigen (NY-ESO- SS,TM,zf-C2H2 8.5

458963 AI701393 Hs.278728 Rad and Gem-related 2 (rat hom ras.SS.Peptidase M10,hemo 8.5

406868 AA505445 Hs.300697 immunoglobulin heavy constant SS,TM,ig 8.3

434105 AW952124 Hs.13094 presenilins associated rhomboi TM,Rhomboid,SS,TM 8.3

421726 AK001237 Hs.319088 hypothetical protein FU10375 TM 8.3

421707 NM 014921 Hs.107054 lectomediπ-2 Lafrophilin,OLF,7tm_2,GaI 8.2

453898 AW003512 Hs.232770 arxhidonate lipoxygenase 3 SS,TM,lipoxygenase,PLAT,s 8.2 456672 AK002016 i Hs.114727 Homo sapiens, clone MGC:16327, SS,PK,PK_C,myosin_head,Rh 8.2

421592 AF009801 Hs.105941 bagpipe homeobox (Drosophila) homeobox.SS 8.2

409829 M33552 Hs.56729 lymphocyte-specific protein 1 Caldesmon,SS,Ribosomal_S2 8r1

444341 AI142027 Hs.146650 ESTs SS,TM,Reprolysin,Pep M12B 8.0

413762 AW411479 • Hs.848 FK506-biπding protein 4 (59kD) FKBP,TPR,SS 8.0

436685 W28661 Hs.5288 Homo sapiens mRNA; cDNA DKFZp4 SS,TM,pkinase,Activin rec 8.0

420932 AW374605 Hs.11607 ESTs, Weakly similar to T21697 SS,bZIP_Maf 8.0

431493 AI791493 Hs.129873 ESTs, novel cytochrome P450 SS,p450,SS 7.9

447598 AI799968 Hs.199630 ESTs SSJM 7.9

415758 BE270465 Hs.78793 protein kinase C, zeta pkinase,DAG_PE-bind,pkina 7.8

457022 AW377258 gb:MR2-CT0222-261099-003-a10 C SS,Ribosomal_L7Ae 7.8

426440 BE382756 Hs.169902 solute earner family 2 (fxil sugar tr,SS,TM,sugar fr 7.8

432747 NM 014404 Hs.278907 calcium channel, voltage-depen PMP22_Claudin,SS,TM,PMP22 7.8

441084 W24563 Hs.9911 hypothetical protein FLJ 11773 SSJM.hoπrione rx,zf-C4 7.8

424443 AI751281 Hs.284161 hypothetical protein from EURO SS,TM,SS,TM 7.7

424198 AB029010 Hs.143026 KIAA1087 protein SS,TM,Na_Ca_Ex,Calx-beta, 7.6

430513 AJ012008 Hs.241586 G6C protein SSJM.GST Cabhydrolase 7.6

417900 BE250127 Hs.82906 CDC20 (cell division cycle 20, WD40,SS,TM,fπ3,EGF,fn3,ig 7.6

432891 AF161483 Hs.279761 HSPC134 protein SS,TM,ubiquitin,Transglut 7.5

432234 AA531128 Hs.115803 ESTs SS 7.5

453485 BE620712 Hs.33026 hypothetical protein PP2447 SSJM 7.5

441327 AK001706 Hs.7778 hypothetical protein FU10751 SS,TM,7tm 1 7.5

436540 BE397032 Hs.14468 hypothetical protein MGC14226 SSJM 7.5

418256 AW845318 Hs.12271 f-box and leucine-rich repeat SS,SS,TM,HSF DNA-bind 7.5

457274 AW674193 Hs.227152 -mannan-binding lectin serine p SS,TM,SS,TM,Clathrin_lg_c 7.5

437141 BE304917 Hs.31097 hypothetical protein FLJ21478 SS,TM,Glycos_fransf_4 7.5

425428 AL110261 Hs.157211 DKFZP586B0621 protein C1q,Collagen,SS 7.4

431934 AB031481 Hs.272214 STG protein SS 7.4

418349 NM 001383 Hs.84183 diptheria toxin resistance pro Diphthamide.syn.SS 7.4

430600 AW950967 Hs.274348 HLA-B associated transcript-3 ubiquitin,SS,TM,G-patch,a 7.3

421758 BE397336 Hs.1422 Gardner-Rasheed feline sarcoma SH2,SH3,pkinase 7.3

412841 AI751157 Hs.101395 hypothetical protein MGC11352 SSJM 7.3

418313 BE244231 Hs.84038 . CGI-06 protein SS.wap 7.3

429367 AB007867 Hs.278311 plexin B1 Sema,PSI,TIG,SS,TM,TIG,Se 7.3

418837 U48263 Hs.89040 prepronociceptin Opiods neurapep.SS 7.2

423015 U18548 Hs.123034 G protein-coupled receptor 12 TM 7.2

440188 AK001812 Hs.7036 N-Acetylglucosamine kinase ROK,SS,TM 7.2

421975 AW961017 Hs.6459 hypothetical protein FU11856 SSJMACAT 7.2

423858 AL137326 Hs.133483 Homo sapiens mRNA; cDNA DKFZp4 SSJM 7.2

446143 BE245342 Hs.306079 secβl homolog secY.SSJM 7.2

417704 NM 001747 Hs.82422 capping protein (xtiπ filamen Gelsolin.SS.Gelsolin 7.2

440869 NM 014297 Hs.7486 protein expressed in thyroid lxtamase_B,SS,XRCC1_N,BR 7.1

435099 AC004770 Hs.4756 flap structure-specific endonu XPG_N,XPG_l,5_3_exonuclea 7.1

438856 N40027 Hs.7473 ESTs SSJM.connexin 7.1

426268 AF083420 Hs.168913 serine/threoniπe kinase 24 (St pkiπase.pkinase 7.1

418373 AW750770 Hs.84344 CGI-135 protein SS,TM,PMP22_Claudin,20G-F 7.1

445087 AW893449 Hs.12303 suppressor of Ty (S.cerevisiae S1,SH2,Ribosomal_L23,pkin 7.1

421748 NM.014718 Hs.107809 KIAA0726 gene product cadherinJMJPR 7.1

413837 AW163525 titin-cap (telethonin) SS.Methyltransf 3 7.0

426691 NM 006201 Hs.171834 PCTAIRE protein kinase 1 pkinase,SS,UCH-2,UCH-1,rr 7.0

409125 R17268 Hs.343567 axonal transport of synaptic v SS,kinesin,PH,FHA,kinesin 7.0

424251 AA677466 Hs.143696 coxtivator-associated arginin SS,SNF2_N,helicase_C,brom 7.0

431630 NM 002204 Hs.265829 integriπ, alpha 3 (antigen CD4 integriπ A,FG-GAP,Rhabd_g 7.0

428156 BE269388 Hs.182698 mitochondrial ribosomal protei SS 7.0

459255 AI493244 Hs.239500 hypothetical protein MGC13114 SS 7.0

441323 AA928413 Hs.159089 ESTs, Weakly similar to ALU7 H SS,Peptidase C1,zf-C2H2 6.9

455928 BE170313 gb:QV4-HT0536-040500-193-g02 H SS 6.9

420856 BE513294 Hs.205736 HLA class II region expressed kazal,SS,TM,ig,pkinase 6.9

421543 AK000519 Hs.105606 hypothetical protein FU20512 TM 6.9

442296 NM.007275 Hs.8186 lung cancer candidate SS,TM,Glyco_hydro_56,Glyc 6.9

445937 AI452943 Hs.321231 UDP-Gal:betaGlcNAc beta 1,4- g Galxtosyl T 2,SS,TM,tsp 6.9

439732 AW629604 Hs. 67641 hypothetical protein from EURO SS,TM,SS,TM,A2M,A2M_N,NTR 6.8

429542 AF038660 Hs.206713 UDP-Gal:betaGlcNAc beta 1,4- g Gal tosyl_T_2,ig,SS,TM,A 6.8

420190 AI816209 Hs.95867 hypothetical protein EST00098 SS.dyπamin 2,dyπamiπ,PH,G 6.8

408215 BE614290 syntaxin 10 SS,SS,TM,HLH,TRM,zf-CCCH 6.7

410277 R88621 Hs.26249 ESTs, Weakly similar to T2D3.H SSJM.SS 6.7

419667 AU077005 Hs.92208 a disintegrin and metalloprote disintegrin.Reprolysin.Pe 6.7

448677 AI560769 ESTs SSJM 6.7

425228 NM 005253 Hs.301612 FOS-like antigen 2 bZIP.SS 6.6

432538 BE258332 Hs.278362 male-enhanced antigen SS,TM,AAA,Ribosomal L2 6.6

421864 BE387198 Hs.108973 dolichyl-phosphate mannosyltra SS,TM,SS,TM 6.6

429962 M69113 Hs.226795 glutathione S-transferase pi GST_C,GST_N,SS,efhand 6.6

406867 AA157857 Hs.182265 keratin 19 filament,bZIP,SS,filament 6.6

426068 AF029778 Hs.166154 jagged 2 DSL,EGF,vwc,granUlin,SS,T 6.5

419344 U94905 Hs.277445 dixylglycerol kinase, zeta (1 ank,DAGKa,DAGKc,DAG_PE-bi 6.5

424681 AA054400 Hs.151706 KIAA0134 gene product helicase_C,PRK,SS,TM,7tm 6.5

417903 NM 002342 Hs.1116 lymphotoxin beta receptor (TNF TNFR_c6,SS 6.5

423876 BE502835 Hs.15463 Homo sapiens, clone IMAGE:2959 SS.efhand 6.4

433439 AA431176 Hs.133230 ribosomal protein S15 TM,SS,TM,TPR,ras 6.4

441379 AW175787 Hs.334841 selenium binding protein 1 SS.RFX.DNA binding 6.4

432968 BE614192 Hs.279869 melanoma-associated antigen re SS,TM,RGS,DIX 6.4

456863 T16837 Hs.4241 ESTs fusion_gly,homeobox,TM 6.4

432269 NM.002447 Hs.2942 mxrophage stimulating 1 recep pkinase,Sema,PSI,TIG,A4_E 6.4

425676 AW410656 Hs.159161 Rho GDP dissociation inhibitor Rho_GDI,homeobox,SS,Cytid 6.4 443420 R06846 Hs 191208 ESTs SS 64

436322 AL355092 Hs 120243 parvin, gamma CH,SS,TM,CTF_NFI 64

440088 BE559877 Hs 183232 hypothetical protein FU22638 SS,zf-C3HC4,SPRY,zf-B box 64

447665 BE044245 Hs 30011 hypothetical protein MGC2963 SSJM 63

431785 AA292385 Hs 268763 Breakpoint cluster region prot BAF,kazal,TM 63

422714 AB018335 Hs 119387 KIAA0792 gene product DUF221,SS,TM,TGFb_propept 63

434916 AF161383 Hs 284207 Homo sapiens, Similar to RIKEN TM 63

414551 AI815639 Hs 76394 enoyl Coenzyme A hydratase, sh ECH,PeptιdaseJJ7,SS,TM 63

413254 U40272 Hs 75253 isocitrate dehydrogenase 3 (NA isodh.SS 63

458367 AA088470 Hs 83135 Homo sapiens, Similar to RIKEN SS,tRNA-syπt_2d 63

415010 NM 04203 Hs 77783 membrane-associated tyrosine- pkιnase,SS,PMP22 Claudin 63

410076 T05387 Hs 7991 ESTs SS 63

412940 BE295701 ' Hs 819 homeo box B7 homeobox,SS,homeobox,home 62

440042 AI073387 Hs 133898 ESTs SS 62

414023 BE243628 gb TCBAP1D1053 Pediatπc pre-B SS 62

414513 AW239400 Hs 76297 G protein-coupled receptor kin pkιπase,RGS,pkιnase C,SS, 62

446662 NM.013323 Hs 15827 sorting nexm 11 PX.SS 62

409882 AJ243191 Hs 56874 heat shock 27kD protein family HSP20,SS,TM,zf-C2H2,BTB,E 62

414576 AK000405 Hs 76480 ubiquitin-like 4 ubιquιtιn,SS,TM,G6PD,G6PD 62

447507 H59696 Hs 18747 POP7 (processing of precursor, SS,TM,WD40,vwd,MAM,EPO TP 62

453447 AW771318 Hs 326586 hypothetical protein MGC11134 SSJPR 61

435968 AW161481 Hs 111577 integral membrane protein 3 TM 61

424441 X14850 Hs 147097 H2A histone family, member X hιstone,CBFD NFYB HMF.SS, 61

434558 AW264102 Hs 39168 ESTs SS,TM,LRRCT,LRR 61

434202 BE382411 Hs 3764 guanylate kinase 1 Guanylate kin.CoaE.Viral 61

432183 AW151952 Hs 46679 hypothetical protein FLJ20739 SS 60

444416 AW288085 Hs 11156 hypothetical protein zf-C3HC4,SpoA,PHD,TM,syna 60

447205 BE617015 Hs 11006 ESTs, Moderately similar to T1 SS,TM,LRRCT,Sema 60

407704 BE315072 Hs 78768 malignant cell expression-enha TM,MBOAT,SS,TM 60

453190 AB002354 Hs 32312 KIAA0356 gene product PH,PHD,RUN,SS 60

439975 AW328081 Hs 6817 inosme tπphosphatase (nucleo Ham1p_lιke,SS 60

449514 AW970440 Hs 23642 protein predicted by clone 236 SS,PX,arf,lιpocalιn,PHD,z 60

432805 X94630 Hs 3107 CD97 antigen SS,TM,7tm 2,GPS,EGF,SS,TM 60

414362 AI347934 Hs 75932 N-ethylmaleimide-sensitive fac NSF.SSJM 60

417483 BE549343 Hs 82208 acyl Coenzyme A dehydrogenase, Acyl-CoA_dh,Acyl-CoA_dh M 60

427988 AA789333 Hs 181349 hypothetical protein 628 SS.SS 60

423473 H49104 Hs 129888 hypothetical protein FLJ14768 zf-C2H2,SS,rrm,ENTH 60

406773 AA812424 Hs 76067 heat shock 27kD protein 1 HSP20.SS 59

409938 AW974648 gb EST386752 MAGE resequences, SS,Adap_comp_sub,GYF 59

424959 NM 005781 Hs 153937 xtivated p21cdc42Hs kinase pkιnase,SH3 59

453082 H18835 Hs 31608 hypothetical protein FLJ20041 SSJM.ion.traπs 59

452094 AF049105 Hs 27910 cenfrosomal protein 2 bZIP,5_3_exonucIease,M,SS 59

451524 AK001466 Hs 26516 hypothetical protein FU10604 SS.SS JM.pkinase pkinase 59

427438 AW328515 Hs 178011 hypothetical protein FLJ20257 SSJM 59

439685 AW956781 Hs 293937 ESTs, Weakly similar to FXD2.H SS.PWWPJSC22 59

440511 AF132959 Hs 7236 eNOS iπterxtiπg protein SS,TM,MAGE,Rιbosomal_S17, 59

417334 AA337572 Hs 157240 hypothetical protein MGC4737 SSJM.ioπ trans 59

425976 C75094 Hs 334514 NG22 protein SS,TM,pkιnase,SH2,SH3,BNR 58

433173 Z35093 Hs 3196 surfeit 1 SURF1,SS,TM,SURF1,SURF4 58

437891 AW006969 Hs 6311 hypothetical protein FLJ20859 TM.SET 58

410239 AI568350 Hs 61273 hypothetical protein MGC2650 SS.ARTJM 58

458060 R95860 Hs 293629 hypothetical protein MGC3121 SS 58

409591 AA532963 Hs 9100 Homo sapiens cDNA FU13100 fis SS,TM,LIM,homeobox 58

409686 AK000002 Hs 55879 Homosapiens mRNA, cDNA DKFZp4 SS,ABC_tran,SS,TM 58

450778 U81375 Hs 25450 solute earner family 29 (nucl Nucleosιde_tran,SS,TM,HSP 58

423612 NM.002067 Hs 1686 guanine nucleotide binding pro G-alpha,arf,SS,G-alpha 58

422701 NM 014699 Hs 119273 KIAA0296 gene product zf-C2H2,GST_C,PHD,SS,TM,H 58

412958 BE391579 Hs 75087 Fas-xtivated senne/threoπine SS.pkinase 58

436957 AA902488 Hs 122952 ESTs SS,DAGKc,DAGKa,RA,DAG_PE- 58

423158 H97991 Hs 193313 Target CAT MoaA_NιfB_PqqE,SS,TM 58

414788 X7B342 Hs 77313 cyclm-dependent kinase (CDC2- pkinase 58

420904 AL035964 Hs 100221 nuclear receptor subfamily 1, hormone_rec,zf-C4,SS,DNA_ 57

410431 BE261320 Hs 158196 transcπptional adaptor 3 (ADA pkinase 57

420508 AJ270993 Hs 98428 homeo box B6 homeobox,SS,homeobox,home 57

435593 R88872 Hs 4964 DKFZP586J1624 protein Herpes HEPA.SS 57

433064 D79991 Hs 30002 SH3-coπtaιnιπg protein SH3GLB2 TM 57

451920 AA224483 Hs 27239 DKFZP586K0524 protein SS,TM,SS,TM 57

453054 AI878908 Hs 31547 Target CAT SS 57

415117 AF120499 Hs 78016 polynucleotide kinase 3'-phosp Viral.helicasel ,SS,Amιno_ 57

413163 Y00815 Hs 75216 protein tyrosine phosphatase, fn3,ιg,Y_phosphatase,SS,T 57

425246 AI085561 Hs 155321 serum response fxtor (c-fos s SRF-TF,fiavodoxιn,SS,TM,p 57

433271 BE621697 Hs 14317 nucleolar protein family A, me SSJM 57

448484 BE613340 Hs 334725 Homo sapiens, Similar to RIKEN TM,SS,TM,Kunιtz_BPTI 57

449139 BE268315 Hs 23111 phenylalanine-tRNA synthetase- neur,SS,zf-C2H2,DNase_ll 57

449181 X96783 Hs 23179 synaptotagmm V C2,SS,TM,Y_phosphatase,Tr 56

414457 AW514320 Hs 76159 ATPase, H transporting, lysoso ATP-synLC,SS,TM,pkιnase 56

424964 AW161271 Hs 153961 ARP1 (xtm-related protein 1, xtiπ.SS 56

415193 AL048891 Hs 12185 hypothetical protein MGC14333 SSJM.amiπotraπ 1 2.LRR 56

407754 AA527348 Hs 288967 Homo sapiens cDNA FU14105 fis SS,TM,SS,TM,TSPN,tsp 3.SE 56

413049 NM 002151 Hs 823 hepsin (transmembrane protease frypsm,SS,TM,ATP1G1 PLM 56

454252 H50256 Hs 63236 πbosomal protein S15a SS 56

431787 AW972024 Hs 343661 ret finger protein SS,WD40,pkιnase 56

431607 AB033097 Hs 183669 KIAA1271 protein SSJM 56

406782 AA430373 gb zw20f11 s1 Soares ovary turn SS 56 444364 AL137294 Hs 10964 hypothetical protein FU22351 SS,TM,pkιnase 56

427834 AA506101 Hs 285813 hypothetical protein FU11807 SSJM 55

443759 BE390832 Hs 134729 FXYD domain-containing ion tra SS,TM,ATP1G1_PLM_MAT8,ATP 5-5

416322 BE019494 Hs 79217 pyrralιne-5-carboxylate reduct P5CR,Octopιne DH N,SS,thι 55

406673 M34996 Hs 198253 major histocompatibility compl SS,TM,MHC_ll_alpha,ιg,SS, 55

415351 U44755 Hs 78403 small nuclear RNA xtivatmg c SSJM.pkmase 55

411030 BE387193 Hs 67896 7-60 protein SS.Collagen.CoIlagen 55

410653 BE383768 Hs 65238 95 kDa retinoblastoma protein zf-C3HC4,SS,SNF2_N,helιca 55

433012 NM 004045 Hs 279910 ATX1 (antioxidant protein 1, y HMA.SSJM 55

437741 BE561610 Hs 5809 putative transmembrane protein SS,TM,SS,TM,RA,VPS9,SH2 55

421883 X55079 Hs 1437 glucosidase, alpha, xid (Pomp frefoιl,Glyco_hydro_31,SS 54

427361 AW732480 Hs 7678 cellular retinoic xid-bmding SS,TM,amιnotran 1.2.LRR 54

411574 BE242842 Hs 6780 protein tyrosine kinase 9-lιke cofilin.ADF.SSJM 54

457313 AF047002 Hs 241520 transcriptional coxtivator SS,rrm,SS,Cytιdylyltransf 54

428345 AI242431 Hs 118282 PAP-1 binding protein SSJM 54

434845 BE267057 Hs 325321 hypothetical protein R32184.1 SS,TM,CH,calponιn,ARID 54

427162 AB011133 Hs 173864 KIAA0561 protein SS,pkιnase,PDZ,SS,SH2,Rho 54

447402 H54520 Hs 18490 hypothetical protein FU20452 SSJM 54

433676 AW371389 Hs 250173 hypothetical protein FU13158 SS 54

424373 AJ133798 Hs 146219 copine VII C2.SS 54

423402 BE167615 Hs 141556 Homo sapiens cDNA FU 12976 fis SS 54

409983 D50922 Hs 57729 Kelch-like ECH-ass∞iated prot BTB,Kelch,SS,TM 54

450184 W31096 Hs 237617 Homo sapiens, clone IMAGE 3447 SS 53

431629 AU077025 Hs 265827 interferon, alpha-mducible pr pkιnase,SH2,SH3 53

430413 AW842182 Hs 241392 small inducible cytokine A5 (R IL8.SS 53

440333 AI378424 Hs 288761 hypothetical protein FU21749 SSJMJP frans.pkinase.pk 53

424927 AW973666 Hs 153850 hypothetical protein C321D24 SSJM 53

412276 BE262621 Hs 73798 mxrophage migration inhibitor MIF,SS,TM,MIF,sugar tr 53

416181 AA174126 Hs 332163 ESTs SS,TM,GalP_UDP_traπsf,Gal 53

440609 AI287585 Hs 7301 G protein pathway suppressor 2 SS,Acyl-CoA_dh,Acyl-CoA_d 53

435327 BE301871 Hs 4867 mannosyl (alpha-1,3-)-glycopro SS,HLH,Myc N term,Myc-LZ, 52

421139 AW953933 Hs 301372 KIAA1552 protein SSJM 52

453449 W16752 Hs 32981 sema domain, immunoglobulin do SS,Sema ιg,PSI,SS,TM,G-al 52

414411 X54079 Hs 76067 heat shock 27kD protein 1 HSP20.SS 52

440906 AW161556 Hs 240170 hypothetical protein MGC2731 SS,TM,Fuπn-lιke,pkιnase, 52

421899 AJ011895 Hs 109281 Nef-associated fxtor 1 Virus HS,bZIP,G-gamma,Myo 52

439473 AI215529 Hs 144787 ESTs SS 52

451585 AK001171 Hs 326422 hypothetical protein MGC4549 SS.Metallophos 52

407191 AA608751 gb ae56h07 s1 Stratagene lung SS.Peptidase C1 52

427515 T79526 Hs 179516 integral type I protein EMP24 GP25L.SS 52

405325 C14000786* gι|7023514|dbj|BAA9 SS 52

434119 AF193844 Hs 3758 COP9 complex subunit 7a SS 51

413052 BE249841 gb 600942857F2 NIH.MGC.15 Homo TM.SSJM 5 1

445109 AF039916 Hs 12330 ectonucleoside tnphosphate di SS,TM,GDA1_CD39,SS,TM pho 5 1

409323 H28855 Hs 53447 Homo sapiens mRNA, cDNA DKFZp7 TPR,SS,TM,pkιnase,ιg 5 1

438707 L08239 ammo xid system N transporte SS,TM,ACAT,MBOAT,SS,TM,TB 51

442599 AF078037 Hs 324051 RelA-associated inhibitor SH3,ank,SS,TM,HHH,ιg 51

420372 AW960049 Hs 293660 Homo sapiens, clone IMAGE 3535 SS 51

436576 AI458213 Hs 77542 ESTs SS,TM,7tm 1,DnaJ 5 1

439012 BE383814 Hs 6455 RuvB (E coli homolog)-lιke 2 AAA,DnaB,UPF0079,SS,Cys_k 5 1

418910 Z25821 Hs 89466 Homo sapiens, Similar to dodec ECH,SS,TM,amιπotran_3,ABC 5 1

414849 AW372721 Hs 291623 ESTs, Weakly similar to unname TM.pkmase 5 1

425743 BE396495 Hs 159428 BCL2-assocιated X protein Bcl-2,SS,ferπtιn,Bcl-2,e 5 1

418231 AA326895 Hs 83848 tnosephosphate isomerase 1 TIM,SS,TM,zf-UBP,UCH-2,UB 50

419238 AW959538 Hs 321214 hypothetical protein DKFZp564D SSJM.WH2 50

441917 AI989925 Hs 24891 ESTs, Highly similar to unkπow SS,TM,Ammonιum_fransp 50

437617 AI026701 Hs 5716 KIAA0310 gene product SS,zf-C3HC4,Peptιdase M16 50

412867 AU076861 Hs 74637 testis enhanced gene transcπp UPF0005.SSJM 50

419579 W49529 Hs 296200 hypothetical protein AF053356. MSP domaιπ,SS,TM,CUB,NTR, 50

425824 AI939563 Hs 159589 ESTs, Moderately similar to RE SS.PHD 50

439414 NM 001183 Hs 6551 ATPase, H transporting, lysoso SS,SS,TM,GDI,Sema,TIG,PSI 50

436042 AF284422 Hs 119178 cation-chloπde cotraπsporter- SSJM.aa permeases.SSJM, 50

410775 AB014460 Hs 66196 nth (E coli endonuclease III)- HhH GPD,SS,TM,REJ,PLAT,PK 50

453350 AI917771 Hs 61790 hypothetical protein FU23338 SS,SS,TM,EMP70,PA28_alpha 49

400300 X03363 HER2 receptor tyrosine kinase pkinase 49

426811 BE259228 Hs 172609 nucleobiπdm 1 efhand,SS,TM,GFO IDH MocA 49

421179 U72664 Hs 148495 proteasome (prosome, mxropain UIM,SS,TM,PMP22_Claudιn,P 49

429762 AI346255 Hs 216354 πng finger protein 5 SS,zf-C3HC4,Palm thioest 49

419250 AW770185 U5 snRNP-specific protein, 116 SS ,TM,7tm_1 ,BAH,zf-CXXC,D 49

426831 BE296216 Hs 172673 S-adenosylhomocysteine hydrola AdoHcyase.SS 49

442103 AA333367 Hs 8088 similar to S cerevisiae Sec6p SS 49

414820 AA371931 Hs 77422 proteolipid protein 2 (colonic SS 49

426347 AA454912 Hs 169407 SAC2 (suppressor of xtm muta SS,RasGEF,RA,RasGEFN,horm 49

423880 BE278111 Hs 134200 DKFZP564C186 protein UPF0120.SSJM 49

429545 AI824164 lymphocyte antigen 6 complex, SSJM 49

443044 N28522 Hs 8935 quinoliπale phosphoπbosyifran QRPTase,QRPTase_N,SS,TM 49

417080 BE392846 Hs 1063 small nuclear πbonucleoprotei SS,S10_plectιn 48

441455 AJ271671 Hs 7854 zinc/iron regulated transporte Zιp,SS,TM,Cytιdylylfransf 48

410182 NM 001983 Hs 59544 excision repair cross-compleme HHH,SS,SH3,ank 48

456062 AI866286 Hs 71962 ESTs, Weakly similar to B36298 SS 48

439270 BE268278 Hs 28393 hypothetical protein MGC2592 SS,TM,HC03 cotransp 48

408985 BE267317 Hs 332040 hypothetical protein MGC13010 SS,TM,ACAT,LRR 48

416976 BE243985 Hs 80680 major vault protein Vault,SS,TM,kιnesιn,zf-C2 48

436057 AJ004832 Hs 5038 neuropathy target esterase cNMP_bιndmg,SS,TM,cNMP_b 48 424501 AI470163 Hs 323342 actin related protein 2/3 comp SS,HhH-GPD 48

409214 AW405967 Hs 333388 Homo sapiens, clone IMAGE 3957 SS,EF1BD,P5CR 48

432716 AI762964 Hs 205180 ESTs SSJM 4,8

414460 L00727 Hs 898 dystrophia myotonica-protein k pkιnase,SS,WD40 48

443329 BE262943 Hs 9234 hypofhetical protein MGC1936 SS,TM,SS,TM,gpdh,gpdh_C 47

426120 AA325243 Hs 166887 copme I C2,SS,ammofran_5 47

405356 ENSP00000247029* SEBOX SS,TM,hemopexιn,Somatomed 47

437118 AB037857 Hs 300591 CD9 partner 1 TM,ιg,SS,TM 47

430609 AA302921 Hs 247362 dimethylargmine dimethylamino SS,TM,GST_C,abhydrolase 47

447131 NM 004585 Hs 17466 retmoic xid receptor respond SSJM.pkmase 47

428469 BE549205 Hs 184488 flotillm 2 Band 7,Flotιllιn,TM 47

405189 Target Exon SS 47

404256 NM 024018* Homo sapiens butyro SS,TM,SPRY,SPRY,ιg 47

457955 AI208986 Hs 121647 ESTs SS,zf-B box,SPRY,SS,Nol1 47

413201 BE275378 Hs 13972 hypothetical protein MGC12972 SS,SH2,RhoGAP,SH3,GILT 47

431115 AB015427 Hs 250493 zinc finger protein 219 zf-C2H2,SS 47

442414 BE408758 Hs 8297 πbonuclease 6 precursor πbonuclease T2,SS,πbonu 47

418289 AW403103 Hs 83951 Hermansky-Pudlak syndrome SS 46

436730 AA045767 Hs 5300 bladder cancer associated prot SS 46

444596 BE560662 Hs 11417 Rab xceptor 1 (prenylated) SSJM.Iig chan.ANF.recept 46

433019 AI208513 Hs 279915 franslocase of inner mitochond zf-Tιm10_DDP,SS 46

431522 AI625859 Hs 258609 protein tyrosine phosphatase, fn3,Y_phosphatase,SS,TM 46

400846 sortilin-related receptor, L(D Idl recepLa,fn3,ldl rece 46

422154 T79045 Hs 168812 ESTs SS 46

420321 D78761 Hs 96657 jiyothetical protein SS,tsp_1,SS 46

439921 AL110209 Hs 6770 LCAT-like lysophospholipase SS,LACT,SS,TM,aa_permease 46

427122 AW057736 Hs 323910 HER2 receptor tyrosine kinase pkinase.Fuπn like.Recep 46

426899 AL043221 Hs 172825 KIAA1037 protein WD40,TPR,SS,TM 46

408116 AA251393 Hs 289052 Homo sapiens, Similar to RIKEN SSJM 46

412974 R18978 Hs 75105 emopamil-bmding protein (ster SSJM,SS,TM,TBC rrm,FtsJ 46

426510 AW861225 Hs 110613 BANP homolog, SMAR1 homolog TM 46

414702 L22005 Hs 76932 cell division cycle 34 UQ_coπ,SS trypsiπ.ig 46

408135 AA317248 Hs 42957 methyltransferase-like 1 Methyltransf 4,SS,p450,Ge 46

445637 W58459 Hs 8949 hypothetical protein MGC4172 SS 46

452190 H26735 Hs 91668 Homo sapiens clone PP1498 Unkn SS 46

409680 W31092 Hs 55847 mitochondπal πbosomal protei SSJM.synaptobreviπ 46

421140 AA298741 Hs 102135 signal sequence rxeptor, delt Herpes UL3,SS,TM,Sema,pkι 46

413407 AI356293 Hs 75339 inositol polyphosphate phospha SH2,SAM,SS,Folate_rec 46

402463 NM.014624 Homo sapiens S100ca efhand.S 100,SS,efhand,S 45

426402 BE387327 Hs 80475 polymerase (RNA) II (DNA direc SS.PGAM 45

406939 M34515 gb Human omega light chain pro SS,ιg,PH 45

417891 W79410 Hs 82887 protein phosphatase 1, regulat SSJFIIS 45

426207 BE390657 Hs 30026 HSPC182 protein SS 45

423664 NM.004714 Hs 130988 dual specificity tyrosιne-(Y)- pkιnase,SS,Fιbπllaπn,CK 45

432562 BE531048 Hs 278422 DKFZP586G1122 protein zf-C2H2,SS,TM,FG-GAP,ιnte 45

427391 W60675 hypothetical protein FU10350 SS.SS 45

432893 NM 016154 Hs 279771 Homo sapiens clone PP1596 unkn ras,arf,SS,20G-Fell_Oxy,2 45

424954 NM 000546 Hs 1846 tumor protein p53 (U-Fraumem P53.SS 45

413815 AL046341 Hs 75562 discoidm domain rxeptor fami F5 F8 type C,pkιnase,SS,T 45

448963 AA459796 Hs 331247 Homo sapiens, clone IMAGE 3610 SSJM 45

416297 AA157634 Hs 79172 solute camerfamily 25 (mito mito carr.SS 45

421962 D82061 Hs 288354 FabG (beta-ketoxyl-[xyl-carr SS,adh short,SS,TM,zf-C3H 45

426726 AA488915 Hs 171955 frophinm associated protein ( SS 45

414427 L19711 Hs 76111 dystroglycan 1 (dystrophin-ass SSJM 45

435891 AW249394 Hs 5002 copper chaperone for superaxid sodcu,HMA,SS,TM,spectπn, 45

453997 AW247615 Hs 37003 v-Ha ras Harvey rat sarcoma vi ras.SS 45

449029 N28989 Hs 22891 solute camerfamily 7 (catio aa_permeases,SS,TM,bZIP 45

432078 BE314877 Hs 24553 hypothetical protein FU 12541 SSJM 45

409650 T08490 Hs 288969 HSCARG protein SS,SS,WD40 45

412833 AW960547 Hs 298262 πbosomal protein S19 SS,TM,ιg,ITAM,Rιbosomal S 44

424133 AA335721 Hs 213628 ESTs SSJM 44

414787 AL049332 Hs 77311 BTG family, member 3 SS.Anti proliferat 44

433046 AA229553 Hs 279945 HSPC023 protein SS 44

417068 AA451910 Hs 85852 hypothetical protein MGC3169 SSJM 44

414814 D14697 Hs 77393 famesyl diphosphate synthase polyprenyl synt.SSJM 44

418267 BE389537 Hs 83919 glucosidase 1 Glyco hydro 63,SS,PH 44

439902 AF174499 Hs 6764 histone dexetylase 6 Hist dexetyl,zf-UBP,SS,G 44

448847 AI587180 Hs 110906 Homo sapiens, Similar to RIKEN TM.SS 44

452160 BE378541 cysteine sulfinic xid decarbo SS 44

416121 X92762 Hs 79021 tafazzm (cardiomyopathy, dila Acyltransferase,SS,TM,GDI 44

449717 AB040935 Hs 23954 cerebral cell adhesion molxul SS.SS 44

425069 AA687465 Hs 298184 potassium voltage-gated channe SS.aldo.keLred 44

413380 AI904232 Hs 75323 prohibitin Band 7,SS,Band 7.SH3 44

452911 AA541537 Hs 112619 metallothionein 1E (functional SS,SS,TM,Sx1 44

436415 BE265254 Hs 343258 proliferation-associated 2G4, Peptidase M24,SS,TM,Peptι 44

429218 AA225065 Hs 198269 Target CAT SS.Nop 44

447987 BE621544 Hs 157160 hypothetical protein MGC2616 SS,NDK,LRRNT,LRRCT,LRR 44

407230 AA157857 Hs 182265 keratin 19 filament,bZIP,SS,filament 43

448886 AL137291 Hs 22451 hypothetical protein FU 10357 SS,PH,RhoGEF,SS,rnaseA 43

421178 BE267994 Hs 102419 zinc finger protein zf-C2H2,SS,TM 43

454031 R36772 Hs 71941 hypothetical protein MGC15677 TM 43

450126 BE018138 Hs 24447 Sigma rxeptor (SR31747 bind SS,ιg,fn3 43

446557 U68566 Hs 15318 HS1 binding protein SS,TM,MIP,UBA 43

413781 J05272 Hs 850 IMP (inosme monophosphate) de IMPDH CIMPDH N,CBS,NPD,S 43 433251 AB040955 Hs 322735 KIAA1522 protein SS,SS,zf C3HC4.SPRY 43

420531 AI652069 Hs 98614 πbosome binding protein 1 (do bZIP.SS 43

432178 X75208 Hs 2913 EphB3 EPH_lbd,fπ3,pkιπase,SAM 43

448988 Y09763 Hs 22785 gamma-aminobutyπc xid (GABA) Neur chan LBD.Neur Chan m 43

426626 AI124572 Hs 323879 inhibitor of kappa light polyp zf-C2H2,SS 43

432956 AL037895 Hs 279861 CGI-31 protein thiored.SSJM 43

428970 BE276891 Hs 194691 retinoic xid induced 3 7tm 3,SS,TM 43

428953 AA306610 Hs 348183 tumor necrosis fxtor rxeptor TNFR_c6,SS 42

401128 C12000644 gιl5729785|ref|NP_00 SS 42

446899 NM.005397 Hs 16426 podocalyxm-like SS,TM,SS,TM 42

407151 H25836 Hs 301527 ESTs, Moderately similar to un SSJNF 42

426613 U96132 Hs 171280 hydroxyacyl-Coenzyme A dehydro adh shortSS 42

408616 R51604 Hs 300842 KIAA1608 protein SS.DENN.DENN 42

446616 R65964 Hs 334873 ESTs, Weakly similar to ALU8.H SS.Zn carbOpept 42

414467 AW903820 Hs 85752 copme II SS 42

455857 T70192 gb yc18d03 s1 Stratagene lung SS,TM,ιsodh 42

401751 RAN binding protein 3 SS,Orexιn,SH2,STAT 42

400563 Target Exon SS,Pep_M12B_propep 42

430237 AI272144 Hs 236522 DKFZP434P106 protein abhydrolase.TM 42

406101 C11000273* gι|12656107|gb|AAK0 SS,TM,7tm 1 42

421661 BE281303 Hs 299148 hypothetical protein FLJ21801 SS.VHP 42

444590 AA457456 hypothetical protein FU20435 SS 42

408187 AF034373 Hs 43509 ataxin 2 related protein SS 42

437696 Z83844 Hs 5790 hypothetical protein dJ37E16 5 SS,Hydrolase,SS,Gal bind 42

400278 -J-NSP00000243264 Dolichyl-dipho SSJM 42

407394 AF005081 gb Homosapiens skiπ-spxific SS 42

447407 BE387301 Hs 18528 Sjogren's syndrome nuclear aut SS,HLH,ras,GSHPx 42

410237 AI750589 Hs 61258 argininosuccinate lyase lyase 1,SS 41

415410 AF037332 Hs 278569 sorting πexm 17 PX,fn3,pkιnase,SAM,EPH lb 41

457757 AA434109 Hs 12271 f-box and leucine-nch repeat SS,F-box,SS,TM,HSF DNA-bi 41

446388 AA292979 Hs 7788 NPD007 protein SSJM 41

412825 AW167439 Hs 190651 Homo sapiens cDNA FLJ 13625 fis SS 41

439737 AI751438 Hs 41271 Homo sapiens mRNA full length SS,C1q,Collagen 41

422256 M64673 Hs 1499 heat shock transcription fxto NA,SS,TM,F-box 41

441164 AB023180 Hs 7724 KIAA0963 protein helιcase_C,SS,RNA_pol_H 4 1

401727 Target Exon A_deamιn,SS 41

411142 NM 014256 Hs 69009 transmembrane protein 3 Galxtosyl_T,SS,Rιbosomal 4 1

458176 AI961519 Hs 140309 Homo sapiens, clone IMAGE 3677 SS,pkιπase,pkιnase_C 41

432178 BE265369 Hs 272814 hypothetical protein DKFZp434E SS.seπne carbpept 4 1

421537 BE383488 Hs 105547 neural proliferation, differen SS,TM,Glyco hydro 47 4 1

421380 D31833 Hs 1372 arginine vasopressm rxeptor 7tm 1 41

422702 AJ011373 Hs 119285 chromosome 9 open reading fram SS,TM,SS,TM 41

434142 U47927 Hs 3759 ubiquitin specific protease 5 zf-UBP,UCH-2,UBA,UCH-1,SS 41

423696 Z92546 Sushi domain (SCR repeat) coπt SS,TPR,vwd,sushι,Somatome 41

427407 BE268649 Hs 177766 ADP-πbosylfransferase (NAD, p BRCT,PARP,zf-PARP,PARP_re 41

413749 AI929320 Hs 75516 tyrosine kinase 2 pkιnase,SS,TM,ιg 41

411927 BE274009 Hs 772 glycogen synthase 1 (muscle) Glycos_traπsf_1,SS 41

433320 D60647 Hs 250879 ESTs, Highly similar to CTXN R SSJM.rrm 4 1

433890 AF103801 Hs 16361 hypothetical protein DAO.SS 4 1

452603 AW410601 Hs 30026 HSPC182 protein SS 41

444486 BE302472 Hs 11314 DKFZP564N1363 protein SS,GKAP,Band_41 41

422556 NM 006245 Hs 118244 protein phosphatase 2, regulat B56,SS,TM,Atrophιπ-1,Exo 41

447347 AA570056 Hs 122730 ESTs, Moderately similar to Kl TM.SS 41

428284 AA535762 Hs 183435 NM.004545 Homo sapiens NADH de SS,TM,Josephιn,UIM,Joseph 4 1

426551 AA381268 Hs 323947 ESTs SS.sushi 40

417782 T10149 Hs 4243 hypothetical protein FU 12650 SSJM 40

443639 BE269042 Hs 9661 proteasome (prosome, mxropam proteasome,SS,TM,LACT,try 40

410039 AF207989 Hs 58014 Homo sapiens, Similar to G pro SS,TM,7tm_3,SS,TM 40

452715 Z21093 Hs 30352 πbosomal protein S6 kinase, 5 pkinase 40

442549 AI751601 Hs 8375 TNF receptor-associated fxtor zf-C3HC4,MATH,zf-TRAF,SS, 40

430603 AA148164 Hs 247280 HBV associated fxtor SS,zf-C3HC4,zf-RanBP,pkιn 40

427239 BE270447 ubiquitin earner protein UQ_coπ,SS,TM 40

402665 Target Exon SS,TM,ιg,DSPc 40

413818 BE161405 Hs 79 hypothetical protein MGC15429 SS,KH-domaιn,WD40,Rι bosom 40

406819 M88359 gb Homo sapiens DNA-bindmg pr SS.rrm 40

412656 AF006011 Hs 74375 dishevelled 1 (homologous to D SS,PDZ,DEP,DIX,Dιshevelle 40

437546 AW074836 Hs 173984 T-bo 1 SS,TM,T-box,GTP CDCLRRCT 40

419489 AW411280 Hs 90693 replication initiation region zf-C2H2,LIM,TM 40

410043 D30612 Hs 58167 zinc finger protein 282 zf-C2H2,KRAB,SS,zf-C2H2 K 40

430067 U79458 Hs 231840 WW domain binding protein 2 GRAM.SS 40

408449 NM.004408 Hs 166161 dyπamiπ 1 PH,GED,dyπamιn,dynamιn 2, 40

448099 BE621839 Hs 61976 Homo sapiens cDNA FU 12947 fis SS 40

436656 N35568 Hs 5245 hypothetical protein FLJ20643 SS,TM,sugar_tr,PID 40

424512 X53002 Hs 149846 integπn, beta 5 ιntegπn_B,EGF,SS,TM 40

440346 AI923985 Hs 59621 ESTs, Weakly similar to A40815 SS,TM,ιg,pkmase 39

420065 AW140093 Hs 129926 ESTs SSJM 39

426636 BE242634 Hs 2055 ubiquitin-xtivatmg enzyme E1 ThιF,UBACT,SS,pkιnase,UCH 39

421579 NM 002975 Hs 105927 stem cell growth fxtor; lymph lectin cSSJM 39

427498 NM 003926 Hs 178728 methyl CpG binding domain prat SS.HLH 39

457820 AA341497 Hs 31408 RAR (RAS like GTPASE) SSJM.Rhomboid 39

439998 BE559554 Hs 61790 hypothetical protein FU23338 SS,SS,TM,EMP70,PA28_alpha 39

438662 AA223599 Hs 6351 cleavage and polyadenylation s zf-CCHC,zf-CCCH,thaumatιn 39

414303 NM.004427 Hs 165263 early development regulator 2 SAM.SS 39

435406 F26698 Hs 4884 calcium/calmodulin-depeπdeπt p pkιnase,SS,hexokιnase,hex 39 414168 AW793296 Hs 103845 ESTs, Moderately similar to 15 SS 39

451982 F13036 Hs 27373 Homo sapiens mRNA, cDNA DKFZpδ SS 39

418181 U37012 Hs 83727 cleavage and polyadenylation s CPSF_A,SS,TM 3-9

402793 Target Exon SS,TM,cycIιn,cyclιn C 39

418681 AA287786 Hs 23449 insulin rxeptor tyrosine kma SS.SH3 39

412621 L40397 Hs 74137 transmembrane trafficking prot EMP24 GP25L.SSJM 39

420631 AW976530 Hs 28355 hypothetical protein FU22402 SSJM 39

438483 AW966735 Hs 321635 ESTs, Weakly similar to A46302 SS,TM,IP_frans 39

431472 AK001023 Hs 256549 nucleotide binding protein 2 ( fer4 NιfH,ParA,APS kinase 39

447800 AL080092 Hs 19610 DKFZP564N1362 protein SS,TM,SS,TM 38

436686 AW450205 Hs 305890 BCL2-lιke 1 TM,Bcl-2,BH4 38

408815 AW957974 Hs 25485 hypothetical protein FU22341 SSJM 38

441196 BE397802 Hs 7744 NM.007103* Homo sapiens NADH d Complexl 51K,SNF2_N,helιc 38

433030 AW068857 Hs 279929 gp25L2 protein SSJM.EMP24 GP25L,SS,TM,G 38

408721 BE515274 Hs 47062 polymerase (RNA) II (DNA dirx RNA_POL_M_15KD,SS,COX7a 38

435049 AL122067 Hs 4746 hypothetical protein FU21324 SS.pfkB 38

431347 AI133461 Hs 251664 insulin like growth fxtor 2 ( SSJnsulin, Insulin 38

450835 BE262773 Hs 25584 hypothetical protein FLJ 10767 ArfGap,SS,vwa,TSPN,fn3,Co 38

414134 X60188 Hs 861 mitogeπ-xtivated protein kma pkιπase,SS,pkmase,T-box 38

418090 U57059 Hs 83429 tumor nxrosis fxtor (ligand) TNF.SS 38

448832 AW245212 Hs 22199 ECSIT SS.rrm 38

447256 AW593008 Hs 6126 hypothetical protein dJ1141E15 SS,TM,SS,TM 38

448107 D45853 Hs 20313 protein tyrosine kinase 2 beta Focal AT,pkιπase,SS,Peptι 38

426433 L38969 Hs 169875 thrombospondiπ 3 TSPN.tsp 3,SS,TM,SEA,TSPN 38

431626 AL035681 Hs 265327 -.hypothetical protein DKFZp761l SS 38

430956 AI183529 Hs 2706 glutathione peroxidase 4 (phos GSHPx,SS,TM,ABC_tran 38

450988 BE387614 Hs 25797 splicing fxtor 3b, subunit 4, SSJM.sugar tr.histone 38

434889 BE613631 Hs 283565 FOS-like antιgen-1 bZIP,SS,bZIP,cofilιn_ADF, 38

444734 NM 001360 Hs 11806 7-dehydracholesterol reductase ERG4 ERG24.SSJM 38

411090 BE165650 Hs 339697 VPS28 protein SSJM.CPSF A 38

452135 AI492175 Hs 21446 KIAA1716 protein SS,DIX,PDZ,DEP,Dιshevelle 38

421339 AA070224 Hs 103561 SRp25 nuclear protein ' SS 37

406535 Target Exon SSJM.Ribosomal S19e,ιg,l 37

447281 AA017018 Hs 18021 hypothetical protein FLJ20446 SS,SS,Tektιn,Pιwι,PAZ 37

433126 AB021262 Hs 99816 beta-cateπin interacting prate SSJM 37

425215 AF030291 Hs 155165 zinc finger protein-like 1 PHD,SS,TM,DnaJ,ERG4_ERG24 37

420536 AL117455 Hs 275438 histone dexetylase 7A HιsLdexetyl,SS,Hιst dea 37

417998 AW967420 gb EST379495 MAGE resequences, SSJM 37

430890 X54232 Hs 2699 glypican 1 Glypican.SS 37

427863 AF189712 Hs 181002 MLL septm-like fusion SS.GTP CDCSSJM 37

448606 BE613362 Homo sapiens ubiquitin conjuga SSJM 37

421961 AB032993 Hs 109929 likely homolog of rat GRIP-ass TM,K_tetra ιoπ traπs.HLH, 37

410293 AK000047 Hs 61960 hypothetical protein KJetra.SS 37

425233 Z17861 Hs 155218 E1B-55kDa-ass∞ιated protein 5 SPRY,SAP,SS,TM,SPRY,SAP,p 37

423683 BE388699 Hs 4188 hypothetical protein MGC10812 SS.Peptidase C15,TGF-beta 37

415697 AI365603 Hs 78605 DKFZP566I1024 protein SS,cpn60 TCP1 37

415825 Y18024 Hs 78877 mositol 1,4,5-tπsphosphate 3 SS 37

418052 AA350659 Hs 83347 angio-associated, migratory ce WD40,Bxteπal PQQ.TM.UPF 37

444706 AK000398 Hs 11747 hypothetical protein FLJ20391 SS.SSJM 37

407381 AA420659 Hs 183110 ESTs, Weakly similar to ALUC H SSJM 37

423432 BE252996 Hs 44067 ESTs TM 37

444982 AK002182 Hs 12211 GDP fucose transporter 1 SS,TM,DUF6,SS,TM 37

407777 AA161071 Hs 71465 squalene epoxidase SSJM.Monooxygenase 37

422715 AA332178 Hs 119403 hexosaminidase A (alpha polype Glyco hydro 20,Glyco hydr 37

422609 Z46023 Hs 118721 sialidase 1 (lysosomai sialida SS,TM,BNR,SS,TM,SET,HSP70 37

414732 AW410976 Hs 77152 minichromosome maintenance def MCM,RIP,SS,zf-C2H2,KRAB 37

452579 AA131657 Hs 23830 ESTs SS.CN.hydrolase 37

419032 W81330 Hs 58643 ESTs, Highly similar to JAK3B SS,pkιnase,SH2,lnsulιn,pk 36

411165 NM 000169 Hs 69089 galxtosidase, alpha Melibiase.Ribosomal L44,z 36

444000 AI095034 Hs 135528 ESTs SS.HLH 36

441174 BE312775 Hs 294005 Homo sapiens, clone IMAGE 3050 SSJM 36

429491 NM 012111 Hs 204041 chromosome 14 open reading fra SS 36

438433 AB018274 Hs 6214 KIAA0731 protein SS 36

425162 BE514851 Hs 154886 choline kinase like Carn_xyltraπsf,Cholιne k 36

429671 BE379335 Hs 211594 proteasome (prosome, mxropam AAA,NB-ARC,TM 36

421018 AI569028 Hs 129888 hypothetical protein FU14768 zf-C2H2,SS,rrm,ENTH 36

433604 NM 013442 Hs 3439 stomalin-like 2 Band 7,SS,TM,AAA,cdc48 N, 36

451544 AK000429 Hs 26570 hypothetical protein FLJ20422 SS,TM,COX3,SS,TM,SRF-TF 36

444369 AV649296 Hs 282793 ESTs SS 36

406660 X65371 Hs 172550 polypyπmidine frxt binding p rrm,beta-lxtamase,SS,try 36

456503 AW977779 Hs 194613 ESTs SS,TM,bromodomaιn,abhydro 36

451711 AK000461 Hs 26890 cat eye syndrome chromosome re SS,SS,TM,A_deamιnase 36

425394 AA356730 Hs 323949 kangai 1 (suppression of tumor SS,TM,fransmembrane4 36

428011 BE387514 Hs 181418 KIAA0152 gene product Acyl-CoA dh.SS.efhand 36

407627 AI419020 Hs 62620 chromosome 6 open reading fram SS 36

436437 F12200 Hs 5811 chromosome 21 open reading fra SS,Syja_N,Exo_eπdo_phos 36

419418 X75621 Hs 90303 tuberous sclerosis 2 Rap GAPJubeπn.Peptidase 36

440300 N39760 Hs 8859 Homo sapiens, Similar to RIKEN SS 36

448136 AA036680 Hs 20447 protein kinase related to S c pkmase.PBD 36

435977 AL138079 Hs 5012 brain specific membrane anchor SS,TM,SS,TM,ubιquιtιn,Rιb 36

419095 AA234009 Hs 188715 ESTs pkinase.PH.pk ase C 36

447267 AL360143 Hs 17936 DKFZP434H132 protein SS 36

418054 NM 002318 Hs 83354 lysyl oxidase like 2 SRCR,Lysyl oxidase.SSJM, 36

444354 AA847582 Hs 10927 hypothetical protein R33729.1 SS 36 428098 AF030249 Hs 196176 eπoyl Coenzyme A hydratase 1, ECH,Herpes_V23,SS,Gal-bm 36

430622 BE616971 Hs 247478 Homo sapiens, Similar to DNA s G-patch,SS,TM,ubιquιtιn,a 36

440675 AW005054 Hs 47883 ESTs, Weakly similar to KCC1.H pkinase 3-6

409678 NM.005632 Hs 55836 small optic lobes (Drosophila) TM,Peptιdase_C2 36

413097 BE383876 Hs 75196 ankyπn repeat-containing prot ank,SET,SS,TM,pkιnase,SH2 36

427579 AA366143 Hs 179669 hypothetical protein FU20637 HECT.SS.HECT 36

409154 U72882 Hs 50842 interferon-mduced protein 35 SS,ras,Rιbosomal L27e,KOW 35

448528 BE613248 Hs 172084 Homo sapiens, clone IMAGE 3627 SS,PID,SH2 35

444426 AL121105 Hs 11170 RNA binding motif protein 14 rrm,SS,sp∞tπn,PH,rrm,so 35

409297 R34662 Hs 53066 hsp70-ιnterxtιng protein SS 35

441138 T56785 Hs 10101 hypothetical protein FU12875 SS 35

435169 AF148509 Hs 279881 mannosidase, alpha, class 1B, TM.GIyco hydro 47 35

422575 AK000546 Hs 118552 hypothetical protein FU20539 TM,SS,TM,SRCR,Glyco_trans 35

403325 C2000428' gι|7705383|ref|NP_05 SS 35

437895 AB014568 Hs 5898 KIAA0668 protein TM,UL21,Lιpoproteιn_6,GBP 35

449030 AI365582 Hs 57100 Homo sapiens mRNA for FU00016 SS.Synuclem 35

426542 AF190746 Hs 170310 cat eye syndrome chromosome re A_deamιnase,SS,TM,Hydrola 35

439873 BE159253 Hs 300638 ESTs SS 35

428950 BE311879 Hs 194673 phosphoprotem enπched in ast DED,SS,TM,Calsequestπn 35

421564 AB007864 Hs 105850 KIAA0404 protein SS 35

441094 U33819 Hs 7647 MYC-associated zinc finger pro SS,zf-C2H2,LIM,PHD,TFIIS, 35

450007 BE270693 Hs 24301 polymerase (RNA) II (DNAdirec NA.SS 35

422898 AL043101 Hs 127401 DKFZP434A163 protein, selector SSJM 35

444914 AA046947 Hs 12142 WD repeat domain 13 WD40,SS,TBC,rrm 35

420178 D50550 Hs 95659 Jethal giant larvae (Drosophil WD40,SS,TM 35

418984 AA421401 πbosomal protein L18 SSJM 35

414166 AW888941 Hs 75789 N-myc downstream regulated Ndr.abhydrolase.SS 35

409944 BE297925 Hs 57687 four and a half UM domains 3 LIM.SS 35

421458 NM.003654 Hs 104576 carbohydrate (keratan sulfate SS 35

423599 AI805664 Hs 31731 peroxiredoxin 5 AhpC-TSA,SS,hormone rec.z 35

427715 BE245274 Hs 180428 KIAA1181 protein TM,SS,TM,KOW 35

405496 Target Exon SS,tubulιn,SS 35

417911 AA333387 Hs 82916 chaperonin containing TCP1, su cpn60 TCP1,SS,cpn60 TCP1 35

433620 AA604520 Hs 269468 ESTs, Moderately similar to AL SS,UCH-2,UCH-1 35

430053 AF052155 Hs 227949 SEC13 (S cerevιsιae)-lιke 1 WD40,SS,TM,E1-E2_ATPase,C 35

458687 AW024815 Hs 170088 GLUT4 enhancer fxtor SS 35

424679 AL117477 Hs 119960 DKFZP727G051 protein chromo.SS 35

417360 AW651703 Hs 82023 hypothetical protein similar t SSJM.GDA1 CD39.GDA1 CD39 35

439641 AI251317 Hs 33184 ESTs SS,TM,GYF,xtιn,PA 35

426437 BE076537 Hs 169895 ubiquitin-coπjugatmg enzyme E UQ con,SS,TM,Armadιllo se 35

427117 BE258946 Hs 173611 Target CAT complex1_49Kd,SS,TM,ITAM, 34

422051 AW327546 Hs 111024 solute earner family 25 (mito SS.mito carr,SS,mιto carr 34

422759 AA316582 Hs 224571 ESTs SS 34

417230 U40998 Hs 81728 unc119 (C elegans) homolog SS.glycolytic enzy 34

450158 AK001999 Hs 24545 hypothetical protein FU11137 SS,zf-C2H2,SCAN,TFIIS,SS 34

425421 L11669 Hs 157145 tetrxycline transporter-like SS,TM,SS,TM 34

415515 F11327 Hs 167406 gb HSC2VD101 normalized infant SS 34

427868 AI360119 comp Hs 181013 phosphoglycerate mutase 1 (bra PGAM,SS,TM,ldh 34

413503 BE410228 Hs 75410 heat shock 70kD protein 5 (glu SS,HSP70,homeobox,Hydanto 34

413014 AW250533 Hs 75139 partner of RAC1 (arfapt 2) SS,hemopexιπ,Fι!amιn,NHL, 34

457655 AA622968 Hs 71574 hypothetical protein FU14926 SS,P5CR,EF1BD 34

419432 AK001459 Hs 90375 hypothetical protein FU10597 PEP-utιlιzers,PEP-utιlιze 34

421066 AU076725 Hs 101408 branched chain ammotransferas amιnotran_4,TM 34

428038 AW134756 Hs 192477 ESTs SS,Exonuclease,zf-C2H2 34

430352 AW750535 Hs 50742 Homo sapiens cDNA FU23331 fi TM 34

432647 AI807481 Hs 278581 fibroblast growth fxtor rxep ιg,pkιnase,SS,TM,ιg,pkιna 34

421310 AW630087 Hs 103315 frmucleotide repeat containm TM,zf-C2H2,SS,PHD 34

420999 AA338903 Hs 100915 peroxisomal biogenesis fxtor SS 34

409561 U58048 Hs 183138 procollagen (type III) N-eπdop SSJM 34

419727 AW160796 Hs 92700 DKFZP5640243 protein Herpes_env,SS,TM,Peptιdas 34

421267 BE314724 Hs 103081 πbosomal protein S6 kinase, 7 pkιnase,pkιnase C,SS 34

411501 AB002368 Hs 70500 KIAA0370 protein SS,TM,SS,TM 34

448741 BE614567 Hs 19574 hypothetical protein MGC5469 SS 34

407103 AA424881 Hs 256301 hypothetical protein MGC13170 SSJM.trypsin 34

422808 AA449014 Hs 121025 chromosome 11 open reading fra SS,TM,frypsιn,CUB,ubιquιt 34

448173 N95657 Hs 6820 ESTs, Moderately similar to YO SS 34

416535 H61851 gb yr80e10 r1 Soares fetal liv SS,TM,homeobox,LIM 34

406656 M16714 Hs 181392 major histocompatibility comol MHC_l,ιg,SS,TM 34

435669 AI867781 Hs 31819 HT014 SS.abhydrolase 2 34

411077 AW977263 Hs 68257 general transcription fxtor I SSJMJGF-beta 34

427062 AW327785 Hs 173421 KIAA1564 protein SS.Peptidase M24 34

421890 AW959486 Hs 21732 ESTs SS,zf-C3HC4,SPRY 34

412968 AW500508 Hs 75102 alanyl-tRNA synthetase DHHA1,SS,tRNA-synt 2c,DHH 34

439496 BE616501 Hs 32343 Homo sapiens, Similar to RIKEN SS 34

433659 AK001301 Hs 3487 hypothetical protein FU 10439 WD40,SS,TM,Syntaxιn,Synta 33

447578 AA912347 Hs 136585 ESTs, Weakly similar to JC5314 SS 33

441722 AW960504 Hs 173103 FE65-LIKE 2 SSJM 33

452345 AA293279 Hs 29173 hypothetical protein FLJ20515 DSPc,SS,jmjC,F-box 33

451714 AK000344 Hs 26898 hypothetical protein FU20337 SS,TBC,FHA,zf-C3HC4 33

410633 BE546789 Hs 346742 hypothetical protein MGC3260 SSJM 33

410609 BE298441 Hs 287361 ADP-nbosylation fxtor relate arf,ras,SS,arf,Stathmιn 33

414775 AA992036 Hs 172702 ESTs, Weakly similar to (defli SS.PCI 33

428495 NM 013279 Hs 184640 hypothetical protein MGC10781 SSJM.XPG N.XPG l,5 3 exo 33

429215 NM 005341 Hs 2364 GLI-Kruppel family member HKR3 zf-C2H2,BTB,TP2,K tetra.S 33 446618 AL110307 Hs.15591 COP9 subunit 6 (MOV34 homolog, Mov34,SS,zf-C2H2,SCAN 3.3

444868 BE560471 Hs.12101 hypothetical protein SS.PCI 3.3

430041 AW247237 Hs.227835 KIAA1049 protein SS,TM,7tm 1, tubulin 3τ3

416950 AL049798 Hs.80552 dermatopontin SS 3.3

431203 AW248421 Hs.250758 proteasome (prosome, mxropain AAA,Sigma54_xtivat,SS,TP 3.3

432714 Y12059 Hs.278675 bromodomain-coπtaining 4 bromodomain,SS,TM,SNF2_N, 3.3

415674 BE394784 Hs.78596 proteasome (prosome, mxropain SS,proteasome,SS,TM,Cadhe 3.3

426152 BE299190 Hs.167246 P450 (cytochrome) oxidoredu a flavodoxin,FAD_binding,SS 3.3

418440 NM 006936 Hs.85119 SMT3 (suppressor of mif two 3, ubiquitin, SS.UQ con 3.3

410545 U32324 Hs.64310 interleukin 11 receptor, alpha ig,fn3,SS,TM,GalP_UDPJra 3.3

409428 M33680 Hs.54457 CD81 antigen (target of antipr fransmembrane4,cyclin,SS, 3.3

443121 Z19267 Hs.9006 VAMP (vesicle-associated membr TM.MSP domain 3.3

453856 AA804789 Hs.19447 PDZ-LIM protein mystique LIM,SS,SH3,Sorb 3.3

430137 NM.005456 Hs.234249 mitogeπ-xtivated protein kina SS,SH3,PID,SS,PID 3.3

446427 AW295863 Hs.119632 ESTs SS 3.3

400747 Target Exon fn3,ig 3.3

445580 AF167572 Hs.12912 skbl (S. pombe) homolog SS.SS 3.3

452568 AA805634 Hs.300870 Homo sapiens mRNA; cDNA DKFZpδ SS,rrm,Ephriπ,pkinase,ATP 3.3

418558 AW082266 Hs.86131 Fas (TNFRSF6)-ass∞iated via d death,DED,SS,TM 3.3

401655 Target Exon SS 3.3

429460 D56263 Hs.203238 phosphodiesterase 1B, calmodul PDEase.SS.PDEase 3.3

416448 L13210 Hs.79339 lectiπ, galxtoside-biπding, s SRCR.SSJM 3.3

433038 AF192559 Hs.279939 mitochondrial earner homolog TM.mito carr.TM 3.3

440251 AW796016 Hs.332012 Homo sapiens, clone IMAGE:3687 SS,TM,SS,TM,IRK 3.3

412922 M60721 Hs.74870 .H2.0 (Drosophila)-like homeo b SS.homeobox.SS 3.3

432941 W04803 Hs.279851 hypothetical protein FU10241 SS,RNase PH.RNase PH C 3.3

441244 BE612935 Hs.184052 PP1201 protein SSJM.WD40 3.3

438175 AI376727 Hs.122110 ESTs SS,TM,trypsin,kringle,fn2 3.3

423024 AA593731 Hs.325823 ESTs, Moderately similar to AL SS,TM,CD36,CD36 3.3

430120 AW675298 Hs.233694 hypothetical protein FU11350 SS 3.3

419571 AW674962 Hs.91146 protein kinase D2 pkinase.DAG PE-bind,PH,DC 3.3

413019 BE281604 Hs.75140 low density lipoprotein-relate SS 3.3

400299 X07730 Hs.171995 kallikrein 3, (prostate spxif trypsin,SS,trypsin,trypsi 3.3

433519 BE263901 ESTs, Weakly similar to S37431 SSJM 3.2

434702 AL039734 Hs.4099 nardilysin (N-arginine dibasic Peptidase_M16,HC03.cotraπ 3.2

422242 AJ251760 Hs.273385 guanine nucleotide binding pro G-alpha,arf,SS,G-alpha 3.2

430480 AL079399 Hs.241543 DKFZP586F1524 protein SSJM.hemopexin.Somatomed 3.2

452438 BE514230 Hs.29595 JM4 protein SS,TM,KOW,HLH 3.2

456939 AA431633 Hs.163867 NM_002488*:Homo sapiens NADH d SS,tRNA-synL2b,WHEP-TRS, 3.2

421009 AL049709 Hs.343357 Human DNA sequence from clone TM 3.2

411969 X12458 Hs.72980 Protein P3 SBF,SS,TM,G6PD,G6PD C.hex 3.2

409197 N54706 Hs.303025 chromosome 11 open reading fra SS 3.2

417896 AA379770 Hs.82890 defender against cell death 1 DAD.SS.TM 3.2

418026 BE379727 Hs.83213 fatty xid binding protein 4, lipocalin.SS.Iipocalin 3.2

409057 AA702305 Hs.180060 ESTs SSJGFb prapeptideJGF-be 3.2

437869 W91976 Hs.290834 ESTs SS,TM,SH3,zf-C3HC4 3.2

413211 AW967107 Hs.109274 ' hypothetical protein MGC4365 SSJM 3.2

425080 AI393498 inositol 1,4,5-triphosphate re SS.CTF.NFI 3.2

445363 NM 005993 Hs.12570 tubulin-sp∞ific chaperone d ATP-synt B.HEAT PBS.SSJM 3.2

421943 BE616520 Hs.343912 Homo sapiens, Similar to RIKEN SS,TM,SS,TM 3.2

443337 Y07604 Hs.9235 non-metastatic cells 4, protei NDK,SS,adh_short,NDK 3.2

418885 D17530 Hs.89434 drebrin 1 cofilin_ADF,SS,cofilin_AD 3.2

411817 BE302900 Hs.72241 mitogen-xtivated protein kina pkinase.SS 3.2

413891 BE271020 tumor suppressor deleted in or SSJM 3.2

449455 T60748 Hs.278408 hypothetical protein TM 3.2

419193 D29643 Hs.34789 dolichyl-diphosphooligosxchar SS,TM,DDOST 48kD,VP7,SS,T 3.2

406701 AA780613 Hs.62954 ferritin, heavy polypeptide 1 SS,TM,UDPGT 3.2

436467 AW450278 Hs.91681 ESTs, Weakly similar to DCHUO SS,tRNA-syπL1b,tRNA_bind 3.2

446334 U52427 Hs.14839 polymerase (RNA) II (DNA dirx S1.SS 3.2

410270 AF279142 Hs.195727 tumor endothelial marker 1 pre SS,TM,EGF,lxtin_c,sushi, 3.2

445411 AL137255 Hs.12646 hypothetical protein FU22693 SS,hormone_r∞,zf-CCCH 3.2

458018 AI199575 Hs.37716 ESTs SSJM.Oxysterol BP 3.2

426530 U24578 Hs.278625 complement component 4A SS,A2M,NTR,A2M_N,prenyltr 3.2

445604 T08566 Hs.12956 Tax interxtion protein 1 PDZ,SS,TM,P2X_receptor,FG 3.2

443402 U77846 elastin (supravalvular aortic SS,PDZ,LIM,pkiπase 3.2

432416 BE410937 Hs.2985 emerin (Emery-Dreifuss muscula LEM.SS.Ribosomal L10e,Acy 3.2

429662 AI929701 Hs.211586 phosphoinositide-3-kinase, reg SH2,SH3,RhoGAP,SS,GILT,SH 3.2

429150 AF120103 Hs.197366 smoothened (Drosophila) homolo SS,TM,Fz,Frizzled,7tm 2,S 3.2

427729 AB033100 Hs.300646 KIAA1274 protein (similarto m SS 3.2

418151 AA864238.comp Hs.83583 xtin related protein 2/3 comp RhoGEF,REV,PH,SS,TM,Ribos 3.2

448250 NM 016034 Hs.20776 mitochondrial ribosomal protei Ribosomal_S2,SS,lipocalin 3.2

431158 AW859138 Hs.136280 Homo sapiens cDNA: FU22288 fi SS.Exonuclease 3.2

414292 BE388407 Hs.75875 ubiquitin-conjugating enzyme E UQ_con,SS,TM,SAM PNT 3.2

406307 Target Exon SS,TM,7tm_2,SS,TM tm_2,G 3.2

423325 R55565 Hs.347286 hypothetical protein FU22427 SS,TM,Surp,ubiquitiπ,TBC 3.2

427584 BE410293 Hs.179718 v-myb avian myeloblastosis vir NA.SS 3.1

419069 AA233801 ESTs, Weakly similar to CA13.H SS 3.1

431717 BE396150 Hs.6945 mitochondrial ribosomal protei SSJM 3.1

448381 D61580 Hs.21036 Homo sapiens mRNA; cDNA DKFZp4 RhoGAP,SS,TM,SET,zf-CXXC, 3.1

419394 AB011124 Hs.90232 KIAA0552 gene product SS.ig 3.1

436240 BE388673 Hs.5086 hypothetical protein MGC10433 SS,TM,Ets,COX6B,transmemb 3.1

413900 AW409747 Hs.75612 stress-induced-phosphoprotein TPR,SS,TM,DnaJ 3.1

417920 S47833 Hs.82927 adenosine monophosphate dea in A_deaminase,SS,G-alpha,GS 3.1

421819 NM.013403 Hs.108665 zlnedln WD40,pkinase,pkinase 3.1 426362 BE267158 Hs 169474 DKFZP586J0119 protein IF-2B,SS,PP2C 3 1

408917 AW249025 Hs 7768 fibroblast growth fxtor (xid SS,bZIP,cofilιπ ADF.EGF 31

443099 AI372836 Hs 9003 hypothetical protein FU13868 TM 3-1

427022 AW245839 Hs 173255 small nuclear πbonucleoprotei rrm,SS,rrm,SH3,ras,20G-Fe 31

452711 AW967047 Hs 293224 ESTs, Weakly similar to T00375 SS 31

407236 W79485 Hs 173980 nuclear matπx protein NMP200 WD40,SS,TM,PTR2,7tm 1 3 1

452537 AW247390 Hs 77735 hypothetical protein FU 11618 SS.SNF2 N.helicase C 3 1

452139 AA099969 Hs 16331 Homo sapiens cDNA FU21482 fi SS 3 1

447629 AF034790 Hs 19105 franslocase of inner mitochond Tιm17,SS,TM,pkιnase,OTU 31

401097 C12000858* gι|7363437|ref|NP_0 SS,TM,7tm_1,SS 3 1

452736 C01164 Hs 4232 Homo sapiens PAC clone RP1-130 SS,SS,TM,TBC,Surp,ubιquιt 31

435507 AI143579 Hs 26510 vxuolar protein sorting 33B ( SS,S∞1,Sx1 3 1

424934 U75370 Hs 153880 polymerase (RNA) mitochondπal PPR,SS,TM,cNMP_bιndιng,RN 31

413245 BE244334 Hs 75249 ADP-πbosylatioπ fxtor-like 6 SS,TM,kazal,Rιbosomal_S8, 31

409858 NM 006586 Hs 56828 tππucleotide repeat contamin SS,SS,TM,B56 31

424582 AF026849 Hs 150922 BCS1 (yeast homolog) like AAA,SS,PI-PLC-X,PH,PI-PLC 31

431677 AK000496 Hs 306989 hypothetical protein FU20489 SS 3 1

417947 AA323563 Hs 325309 hypothetical protein FU14596 SSJM.PTPA 3 1

409283 NM 004860 Hs 52788 fragile X mental retardation, KH-domaιn,SS,TM,HMG box 31

412813 AF086947 Hs 74617 dynxtin 1 (p150, Glued (Droso CAP GLY.SS 3 1

456535 AA305079 Hs 1342 cytochrome c oxidase subunit V COX5B,SS,p450,xtιn 31

432482 L19267 Hs 275924 dystrophia myotoπica-coπtamiπ WD40,SS,pkιnase,pkιnase 3 1

437256 AL137404 Hs 97871 Homo sapiens, clone IMAGE 3845 TM.SS 3 1

440191 AI990417 tubulin, beta 5 SS,formιmιπofr,prenyltran 30

407972 AA827639 Hs 18587 .KIAA1588 protein SSJM 30

420890 AA434058 Hs 100071 6-phosphogluconolactonase Glucosamine iso.SS 30

440060 AI696387 Hs 126451 ESTs, Weakly similar to A46302 SS 30

452222 AW806287 Hs 21432 SEX gene SS,TM,Sema,TIG,PSI,GDI 30

401772 NM.014520 Homo sapiens MYB bin SS 30

453754 AW972580 Hs 172753 ESTs SS,TM,ras,Rιbosoma! S19J 30

423865 H05202 Hs 133968 FGF receptor xtivatmg protei SSJM 30

450962 BE535647 Hs 25723 Sjogren's syndrome/scleroderma SSJM 30

441954 AI744935 Hs 8047 Fanconi anemia, complementatio TPR,SS,TM,AAA,cdc48 N.Ban 30

412787 D87452 Hs 74579 KIAA0263 gene product zf-CCCH,SS,TM,NTP_transfe 30

422034 AC006486 Hs 333069 Ets2 repressor fxtor Ets,SS,pktnase,PAF-AH lb 30

450788 AI738410 ESTs SSJM 30

452511 BE408178 Hs 285165 Homo sapiens cDNA FU20845 fis SS,thιored,P5CR 30

414380 BE391815 Hs 75981 ubiquitin spxific protease 14 UCH-2,UCH-1,ubιquιtιn,SS 30

407597 AA043925 Hs 339352 Homo sapiens brother of CDO (B SS,TM,SS,TM 30

434955 BE276128 Hs 284286 mitochondnal πbosomal protei SS 30

435632 AF220049 Hs 43549 uncharxteπzed hematopoietic SS.UQ con 30

432465 D56165 Hs 275163 non-metastatic cells 2, protei NDK,SS,NDK 30

430526 AF181862 Hs 242407 G protein-coupled rxeptor, fa 7tm_3,homeobox,SS,TM 30

453412 AJ003290 gb AJ003290 Selxted chromosom pkinase 30

446456 BE613933 Hs 15106 chromosome 14 open reading fra UPF0143.SS 30

433180 AB038651 Hs 31854 K562 cell- enved leucme-zipp TM.Acetyifransf ,TM Acetyl 30

447322 BE617649 Hs 77690 RAB5B, member RAS oncogene fam SS.oxidored molyb.heme 1, 30

422268 N25485 Hs 330310 maternal G10 transcπpt G10,SS,WD40 30

419578 AF064853 Hs 91299 guanine nucleotide binding pro WD40,SS,EPO TPO 30

446929 AA076132 Hs 9460 Homo sapiens mRNA, cDNA DKFZpδ SSJM.WD40 30

TABLE 21 B

Pkey Unique Eos probeset identifier number CAT number Gene cluster number Accession Genbank xcession numbers

Pkey CAT Number Accession 408215 10478.1 BE614290 AA307674 N35629 AA338538 AI193603 AA781096 AI680061 AI613258 AW276647 BE221263 AI348910 AI985031 AI090078 AI359617

AA666391 AI160210 AI446461 AI355345 AI343638 AI343640 AI275091 M78746 AW262795 AW250002 AA503756 AI934519 AW272086 N26520

AA626639

409938 116091 1 AW974648 AA652153 AA649671 AA078582 411674 1253746.1 AW861123 AW861125 AW856717 AW861116 AW856706 AW856788 AW856774 AW856787 AW856780 AW856782 AW856789 AW856772

AW856784 AW856786 AW856776 AW856635 AW856767

413052 1347214.1 BE249841 BE062657 BE062771 BE062636 BE062813 BE062699 BE062895 BE062747 BE062719 BE293541 413837 139363.1 AW163525 AW163255 AW163385 AI929359 BE279279 AA132590 AW157329 AA584408 AW157252 AI692198 AW003514 T24436 AI765658

AW157459 AI810740 AI659582 AI969924 AI929284 AI340993 AI349083 AW299522 AW664650 AW299513 AA132529 AI340991 AI912836

A1341293 AI650609 AA279

413891 139759.1 BE271020 AI763358 AI925430 AI806151 AW003726 T15590 AA649945 AW129911 AI570748 T57492 AA828002 AW237602 AW003539 AI139045

AI950958 BE042625 AW778973 AI287859 AI983931 AW515101 AW150029 AI358496 AI621173 AA846016 AI470921 AW169748 AI991000

AW513748AI04058

414023 1410860.1 BE243628 BE246081 BE247016 BE241984 BE241534 BE246091 BE245679 BE243620 BE245998 BE242329 BE241417 BE241467 BE242522

BE241989 BE241464

416535 1599332 1 H61851 H74099 T67099 417998 171375 1 AW967420AA210915 AA236991 AA210916 418984 181094.1 AA421401 T49326 AA330666 AA328941 W63573 AA758023 AA976306 H52254 AA877107 BE207784 AW664584 AI924890 AA458586 AI422142

AI891097 AI811174 R69866 T49327 AA233722 AA631138 AA910314 AI379416 AI129321 AA861574 AA635649 AI339443 AW009533 AA677036

AA948287 AA62

419069 181650.3 AA233801 BE383487 AA913939 AI632681 AI813277 AI373652 AW134802 AI863574 AW305364 AI858557 AI670746 AI015036 AI935384 AI935317

AW138668 AW204971 AI765223 AA884146 AA973341 AA234062

419250 183289.2 AW770185 AW296271 H11254 AW403510 AI032786 AA767046 AI376115 AI582209 AA460965 A1868663 A1016900 R05715 A1127382 AI660953

AI023644 H00465 AW959578 AA815039 AW292253 R05714 AA815462 AA235654 AA461274 W24933 AA300091 H00515

420160 191054 1 AI492840 AI287657 AA255989 AI698206 AI468558 421572 204022.1 AA531607 AI565370 AI376907 AI811618 AW138145 AW139465 AA421658 AA293069 AW118141 AI214980 AW663502 AI343486 AI553789

AA650416 AI498947 423696 23112.1 Z92546 AA330586 AI570568 AW341487 AI827050 AW298668 AI792189 AI015693 AI733599 AI572251 AI672488 AW193262 AI244716 AI864375

AI206100 AA912444 AI269365 AI640254 AW772466 AI867336 AA627604 H16914 AA358477 AA338009 425080 246559.1 AI393498 R42314 AI088818 AI696468 A1418641 AA573152 F08817 A1910796 AW338984 R39024 AA729145 BE245956 AI093722 AA541730

F09835 AI242755 AA350447 AA865667 T93903 AW081029 AA493711 AA650030 N35995 N21491 T57002 Z25379 AI906851 427239 27647.1 BE270447 AW409921 BE207288 BE207170 D56355 BE263223 BE408171 BE262243 BE392439 BE292738 BE261776 BE314300 BE267719

BE268715 BE513876 BE295291 BE297066 AA210923 BE407519 H513448E622905 A 248281 AW250313 T19021 AA355115 AA316879

BE269633 BE621936 AA290724

427391 27815.1 W60675 AK001212 AA155752 AA878366 AA090872 AB033013 AW249107 AA031890 AA112820 AW366388 N55156 AA326756 AW952294

AA180820 C03570 C04358 W60676 AW248674 AA034989 AA044781 AA074274 H26212 AI800572 AH 27583 AI951785 AA856557 AI571746

H23835 AI589543 A1215670

428092 2869201 AW879141 AA421182 AI734104 AI733923 AA430600 429545 305902.1 AI824164 AI676005 AW129612 AI825903 AA773987 AI823645 AI823860 AA456229 AI824295 AA454622 AI264049 AI090237 AI669787 AI804012

AI306153 W96164 AI298273 AW884073 AW883986

430168 3139271 AW968343 AA468507 AI478223 AW513008 AI762122 AI554512 AA862642 AA468976 433519 368801.2 BE263901 AA596086 AH 90276 AI094806 AI831250 AI572668 AW204652 AI660600 AI922941 R49621 438707 46360.1 L08239 BE618914 AW385394 AW385398 AW385401 AI922683 AA907337 AA160504 AA928142 AA601969 AA010594 BE618528 AA160591 440191 488043 AI990417 AI304400 AI193071 AI742483 AW003408 AW131566 AI400201 AI656740 AI309186 AW665173 AW204722 AI215122 AI200785

BE467373 AI147599 AI215120 AI076110 AI803429 AI262491 AI808243 AI281007 AW135212 AW205103 AI754349 AI004801 AI051273 AW768918

AW103289 AI4

443402 5681.1 U77846AA479373 AA346348AA348194 26867 AA728901 AA715367 AA377787 R64236 AI752721 R77311 AA339685 BE074254AW938712

AW068444 AA330624 AA347098 AA327507 AW391973 AA495763 AA479278 AW605018 T19644 AI204484 AW834745 AW081309 AW090002

A1095659 A1131556 AI56

444590 6116.1 AA457456 AA907921 AI567715 AA579472 T64216 AA373128 F35533 AA722113 T64403 AA653738 F28806 AA595689 AA047537 AA022499

AW440532 F36782 AI554180 AI183767 AI806052 AA160379 AA481678 AI185031 AI148988 AI174482 AA868833 AI674395 AA481440 AI914985

AI698771 AA44

445625 64558.1 BE246743 AA436942 AW024744 AW242177 AA975476 AW385185 R07536 R73462 AV654529 T57442 AI399986 R50073 R48743 AI769689

AI863005 AA317806 AI678000 AW189963 AI986207 AW471273 R73463 AI335104 AI590161 AI469257 AI954604 H21954 T25141 AA856793

R50074 A1708253 AI2

448606 77159.1 BE613362 AA447862 H72036AA393664AI681334AW139128 AA932579 AI302241 AI936800 AW960628AI492148 C06192AA336107 AA808008

AW615212 BE297403 BE298978 AH 87207 AA928695 AI620631 AA938128 AI346527 AI040261 AA808401 AW130326 AI440313 AA868693

AI653329 AI33246

448677 7752171 AI560769 A1857497 A 151454

450788 8468401 AI738410 AW016905 AI971725

452160 901991 1 BE378541 AI863051

453412 9662641 AJ003290 AJ003288 AW276947

455857 13760211 T70192 BE147696

455928 13838991 BE170313 BE158339 BE158290

457022 2744451 AW377258 BE067468 BE067511 BE067515 BE067467 BE067514 AA397442

TABLE 21 C

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham I et al " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489495 Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons

Pkey Ref Strand NLposition

400460 8389428 Plus 35559-36295

400563 9844011 Plus 81941-82434

400747 7329330 Minus 71249-71441

400846 9188605 Plus 3931039474

401097 9965518 Minus 60356-61096

401128 8699792 Plus 37349-37885

401655 9099093 Plus 79556-80132

401727 8134856 Plus 54342-54482

401751 9828651 Plus 139165-139322

401772 9966243 Plus 183917-184042

402365 9454515 Minus 70928-71185

402463 9796896 Minus 8818-8952

402665 8077033 Minus 11824-12090,14290-14544

402793 6136940 Minus 69012-69165

402916 7406502 Minus 361474,541-687

403028 7670577 Minus 114150-114272

403325 8440025 Minus 109763-109926

404256 9367203 Plus 146931-147796

405189 7229907 Minus 168236-168795

405325 6094661 Minus 2581826380

405356 2155224 Plus 36116-36276

405496 8468868 Plus 147706-148062

406101 9124019 Plus 125325-125831

406307 8576099 Plus 95473-95585,98900-99180

406535 7711477 Plus 83135-83362 Table 22A lists about 811 genes up-regulated in ovanan cancer compared to normal adult tissues that are likely to encode extrxellular or cell-surface proteins These were selxted as for Table 20A, except that the ratio of "average" ovanan cancer to "average" normal adult tissues was greater than or equal to 40, the "average" ovanan cancer level was set to the 96th percentile value amongst vaπous ovanan cancer specimens, the "average" normal adult tissue level was set to the 75th percentile value amongst vaπous noπ- malignant tissues, the "average" ovanan cancer value was greater than or equal to 80 units, and the predicted protein contained a structural domain that is indicative of enzymatic function or of transducing an intracellular signal, or of being modulatable by small molxules (e g , pkinase, peptidase, phosphatase, or loπ.traπsporter) Predicted protein domains are noted

TABLE 22A

Pkey Unique Eos probeset identifier number

ExAccn Exemplar Accession number, Genbank accession number UnigenelD Unigene number Unigene Title Unigene gene title Protein Dom Predicted protein domain R1 Ratio of tumor to normal body tissue

Pkey ExAccn UniGene ID Unigene Title Protein Dom R1

407223 H96850 gb yw03b12 s1 Soares melaπocyt 589

430281 AI878842 Hs 237924 CGI-69 protein mito.carr 467

410418 D31382 Hs 63325 transmembrane protease, seπne Idl rxept a trypsin 41 0

431773 BE409442 Hs 268557 plxkstπn homology-like domai PH 371

438424 AI912498 Hs 25895 hypothetical protein FU14996 353

418969 W33191 Hs 28907 hypothetical protein FU20258 SH3 352

453028 AB006532 Hs 31442 RxQ protein-like 4 DEAD,helιcase_C 282

407722 BE252241 Hs 38041 pyπdoxal (pyπdoxme, vitamin pfkB 282

451721 NM 006946 Hs 26915 spxfrin, beta, non-erythrocyt spectπn.PH.CH 279

416819 U77735 Hs 80205 pιm-2 oncogene pkinase 279

430397 AI924533 Hs 105607 bicarbonate transporter relate HC03 cotransp 277

450334 AF035959 Hs 24879 phosphatidic xid phosphatase PAP2 267

418945 BE246762 Hs 89499 arxhidonate 5-lιpoxygenase lipoxygenase.PLAT 253

424420 BE614743 Hs 146688 prostaglandin E synthase MAPEG 25 1

412674 X04106 Hs 74451 calpain 4, small subunit (30K) efhaπd 244

430023 AA158243 Hs 227729 FK506-bιndιng protein 2 (13kD) FKBP 243

444672 Z95636 Hs 11669 laminin, alpha 5 lamιnιn_EGF,lamιnιn_G,EGF 240

413726 AJ278465 Hs 75510 annexm AII annexm 23 1

438951 U51336 Hs 6453 mositol J,3,4-lnphosphate 5/ oxidored.nitro 230

429099 BE439952 Hs 196177 phosphorylase kinase, gamma 2 pkinase 230

431765 AF124249 Hs 268541 novel SH2-contaιnmg protein 1 SH2 224

422645 L40027 Hs 118890 glycogen synthase kinase 3 alp pkinase 224

413436 AF238083 Hs 68061 sphmgosine kinase 1 DAGKc 223

422639 AI929377 Hs 173724 creatine kinase, brain ATP-gua_Ptrans,ATP-gua_Pt 21 5

429869 AI907018 Hs 15977 Target CAT 21 3

418891 NM 002419 Hs 89449 mitogen-xtivated protein kina SH3,pkιnase,pyπdoxal deC 21 1

419138 U48508 Hs 89631 ryanodiπe rxeptor 1 (skeletal RYDR_ITPR,RyR,SPRY,ιon_tr 21 0

432866 BE395875 Hs 279609 mitxhondπal carrier homolog mito.carr 209

452875 BE275760 Hs 30928 DNA segment on chromosome 19 ( Euk_poπn 20 8

426997 BE620738 Hs 173125 peptidylprolyl isomerase F (cy pro.isomerase 208

402916 ENSP00000202587* Bicarbonate t HC03_colraπsp 208

425760 D17629 Hs 159479 galxtosamine (N-xetyl)-6 sul Sulfatase 207

400419 AF084545 Target EGF.ig lectin c,sushι,Xlι 200

419444 NM 002496 Hs 90443 Target CAT fer4 195

459133 U40343 Hs 29656 cyclin-dependent kinase inhibi ank 19 2

447595 AW379130 Hs 18953 phosphodiesterase 9A PDEase 192

422708 AB017430 Hs 119324 kinesin-like 4 kinesin.homeobox 19 0

414837 U24266 Hs 77448 aldehyde dehydrogenase 4 famil aldedh 188

429712 AW245825 Hs 211914 ENSP00000233627* NADH ubiqumo oxιdored_q6 185

425848 BE242709 Hs 159637 valyl tRNA synthetase 2 GST CGST.NJropomyosin 184

451643 M64437 Hs 234799 breakpoint cluster region RhoGEF,RhoGAP,PH,C2 181

447859 AK002194 Hs 19851 peroxisomal biogenesis fxtor 175

426457 AW894667 Hs 169965 chimeπn (chimaenn) 1 DAG.PE bmd.RhoGAP 173

421612 AF161254 Hs 106196 8D6 antigen Idl recepLa 171

421363 NM 001381 Hs 103854 d∞kmg protein 1, 62kD (downs PH.IRS 169

442739 NM.007274 Hs 8679 cytosolic xyl coenzyme A thio Acyl-CoA_hydro 168

420568 F09247 Hs 247735 prot∞adheπn alpha 10 cadhenn 168

421445 AA913059 Hs 104433 Homo sapiens, clone IMAGE 4054 asp 168

425424 NM.004954 Hs 157199 ELKL motif kinase pkιπase,KA1,UBA 167

446329 NM 013272 Hs 14805 solute earner family 21 (orga kazal,OATP_N,OATP_C 165

406620 M81105 Hs 146550 myosin, heavy polypeptide 9, π myosin head.Myosin tait.t 164

429109 AL008637 Hs 196352 neutrophil cytosolic fxtor 4 PX,SH3,OPR 163

429183 AB014604 Hs 197955 KIAA0704 protein PH,Oxysterol_BP 162

444664 N26362 Hs 11615 map kinase phosphatase-like pr DSPc.Rhodanese 162

427640 AF058293 Hs 180015 D-dopxhrome tautomerase MIF,late_protein L2 162

425123 AW205274 Hs 154695 phosphomaπnomutase 2 PMM 160

416006 AA324251 Hs 78950 branched chain keto xid dehyd El.dehydrog 158

412942 AL120344 Hs 75074 mitogen-xtivated protein kma pkinase 158

423366 Z80345 Hs 127610 xyl-Coenzyme A dehydrogenase, Acyl CoA_dh,Acyl-CoA_dh_M 157

426391 AW161050 Hs 169611 sxond mit∞hondπa deπved x 157

424568 AF005418 Hs 150595 cytochrome P450, subfamily XXV p450 155

420029 BE258876 Hs 94446 polyamme-modulated fxtor 1 aldo.ket.red 155

433573 AF234887 Hs 57652 cadheπn, EGF LAG seven-pass G 7tm_2,EGF,cadheπn,lamιnι 154

407619 AL050341 Hs 37165 collagen, type IX, alpha 2 Collagen 153

427326 AI287878 gb qv23f06 x1 NCI_CGAP_Lym6 Ho 7tm_1 ' 152

442620 C00138 Hs 8535 Homo sapiens mRNA for KIAA1668 15 1

458130 AA115811 Hs 6838 ras homolog gene family, embe ras.arf 150

449936 AA938293 Hs 60088 hypothetical protein MGC11314 150

409230 AA852431 Hs 51299 NM.021074 Homo sapiens NADH de complexl 24kD 147

423801 NM.015071 Hs 132942 GTPase regulator associated wi RhoGAP,SH3,PH 140

419639 AK001502 Hs 91753 hypothetical protein 136

419298 AA853479 Hs 89890 pyruvate carboxylase CPSase L_cham,PYC OADA.H 136

426108 AA622037 Hs 166468 programmed cell death 5 DUF122 135

448133 AA723157 Hs 73769 folate rxeptor 1 (adult) Folate.rx 135

418736 T18979 Hs 87908 Snf2-related CBP xtivator pro helicase CAT hook 135

436543 NM 002212 ! Hs 5215 integπn beta 4 binding protei elF6 133

431515 NM.012152 ! Hs 258583 endothelial differentiation, I 7tm_1 133

429469 M64590 Hs 27 glycine dehydrogenase (dxarbo GDC-P 132 431462 AW583672 Hs 256311 gran -like neuroendocππe pep 13 2

444855 BE409261 Hs 12084 Tu translation elongation fxt GTP_EFTU,GTP_EFTU_D3,GTP_ 13 2

423464 NM 016240 Hs 128856 CSR1 protein Collagen 13 1

450787 AB006190 Hs 25475 aquapoπn 7 MIP 130

428539 AW410063 Hs 184877 solute earner family 25 (mito mito carr 130

436014 AF281134 Hs 283741 exosome component Rrp46 RNase_PH,RNase_PH_C 129

416866 AA297356 Hs 80324 seπne/threonine protein phosp Metallophos 129

433867 AK000596 Hs 3618 hippocalcm-like 1 efhand 129

411408 U76666 Hs 69949 calcium channel, voltage-depen lonjrans 128

432329 NM 002962 Hs 2960 S100 calcium-binding protein A S 100,efhand 127

447887 AA114050 Hs 19949 caspase 8, apoptosis-related c ICE p20,DED,ICE p10 127

427448 BE246449 Hs 2157 Wiskott-Aldπch syndrome (xze WH1.PBD.WH2 127

428820 AA436187 Hs 172631 mtegπn, alpha M (complement FG-GAP 127

446603 NM 014835 Hs 15519 oxysterol-bmding protem-rela Oxysterol.BP 126

422633 X56832 Hs 118804 enolase 3, (beta, muscle) enolase 126

446839 BE091926 Hs 16244 mitotic spindle coiled-coil re Troponin 126

414757 U46822 Hs 77252 fragile histidine triad gene HIT 125

428593 AW207440 Hs 185973 degenerative spermatocyte (hom 12 5

432370 AA308334 Hs 274424 N-acetylneuraminic xid phosph Antifreeze.NeuB 12 5

401542 C15001413* gι|10645198|ref|NP_ 124

428782 X12830 Hs 193400 interieukin 6 rxeptor fn3,ιg 123

425999 AW513051 Hs 332981 ESTs, Weakly similar to I38022 FAD_bιndιng_2 123

422301 AI752163 Hs 114599 collagen, type VIII, alpha 1 C1q,Collagen 122

410720 AF035154 Hs 65756 regulator of G-protem sigπall RGS,G-gamma,DEP 122

407143 C14076 Hs 332329 EST , 12 1

421321 NM 005308 Hs 103502 glutamic-pyruvate traπsaminase amιnotran_1_2 121

425251 Z22521 Hs 155342 protein kinase C, delta pkmase.DAG PE-bιnd,pkιna 120

431354 BE046856 Hs 251673 DNA (cytosine 5-) methylfransf PWWP.PHD 120

420421 AF281133 Hs 343589 exosome component Rrp41 RNase_PH,RNase_PH_C 120

416714 AF283770 Hs 79630 CD79A antigen (immunoglobulin- ιg,ITAM,Zn clus 120

427336 NM 005658 Hs 2134 TNF rxeptor-ass∞iated fxtor MATH 120

409799 D11928 Hs 76845 phosphosenne phosphatase like Hydrolase 11 9

436319 H90727 Hs 5123 inorganic pyrophosphatase Pyrophosphatase 11 9

400748 NM.022122 Homo sapiens matπx 11 9

428948 BE514362 FK506-bιndιng protein 3 (25kD) FKBP.PIP5K 11 8

401215 C12000457* gi]7512178Ipir||T30 trypsin 11 7

401281 DKFZP586N2124 protein 11 7

427397 AI929685 Hs 177656 calmodulin 1 (phosphorylase ki efhand.RrπaAD 11 7

453496 AA442103 Hs 33084 solute earner family 2 (fxil sugar.tr 11 7

409608 AF231023 Hs 55173 cadheππ, EGF LAG seven pass G 7tm_2,cadheππ,GPS,lamιnι 11 7

424415 NM 001975 Hs 146580 enolase 2, (gamma, neuronal) enolase 11 7

447495 AW401864 Hs 18720 programmed cell death 8 (apopt pyr.redox 11 6

426928 AF037062 Hs 172914 retinol dehydrogenase 5 (11-cι adh.short 11 6

405371 NM.005569* Homo sapiens UM do pkιnase,LIM,PDZ 11 5

416282 R86664 Hs 167257 brain link proteιn-1 Xlink 11 4

452295 BE379936 Hs 28866 programmed cell death 10 11 4

430390 AB023186 Hs 241161 KIAA0969 protein PH 11 4

430594 AK000790 Hs 246885 hypothetical protein FU20783 PH 11 2

443814 BE281240 Hs 9857 carbonyl reductase 11 2

440242 AW295871 glucose transporter protein 10 11 1

447365 BE383676 Hs 334 Rho guanine nucleotide exchang SH3,PH,RhoGEF 11 1

400843 NM.003105* Homo sapiens sortil Idl recepLa fn3,ldl rxe 11 1

422418 AK001383 Hs 116385 hypothetical protein FLJ10521 RhoGEF 11 0

400232 NM.001895* Homo sapiens casein pkinase 109

426828 NM 000020 Hs 172670 xtivm A receptor type ll-lik pkιnase,Actιvιn rxp 109

431157 AI823969 Hs 132678 ESTs MAPEG 108

422616 BE300330 Hs 118725 selenophosphate synthetase 2 AIRS.AIRS.C 108

406779 AA412048 Hs 279574 CGI-39 protein, cell death-reg 108

400389 AL135841 olfxtory rxeptor, family 2, 7tm 1 108

402207 Target Exon A2M.N A2M 108

435615 Y15065 Hs 4975 potassium voltage-gated channe ιon_frans,KCNQ1_channel 108

452434 D30934 Hs 29549 C-type lectiπ like receptor-1 lxtιn_c 107

402053 C11001722* gι|11436283|ref|XP_ 107

418641 BE243136 Hs 86947 a disintegπn and metalloprote disintegnn.Reprolysin.Pe 106

431512 BE270734 Hs 2795 Ixtate dehydrogenase A I h.ldh C 106

403213 NM.019595 Homo sapiens interse SH3,efhand,C2,PH,RhoGEF 106

412158 BE241740 Hs 785 integπn, alpha 2b (platelet g FG-GAP,ιntegπn_A 106

423673 BE003054 Hs 1695 matπx metalloprotemase 12 (m Peptιdase_M10,hemopexιn 106

403949 C10000813' gι|5453992|ref|NP_0 10 6

457670 AF119666 Hs 23449 insulin rxeptor tyrosine k a SH3 10 5

418416 U11700 Hs 84999 ATPase, Cu transporting, beta E1-E2_ATPase,HMA,Hydrolas 104

419594 AA013051 Hs 91417 topoisomerase (DNA) II binding BRCT 104

422765 AW409701 Hs 1578 bxuloviral IAP repeat-contain BIRJK 104

453023 AW028733 Hs 31439 seπne protease inhibitor, Kun Kunιtz_BPTI 104

425694 U51333 Hs 159237 hexokmase 3 (white cell) hexokιnase,hexokιnase2 104

438800 AB037108 Hs 6418 seven transmembrane domain orp 10 3

402478 Target Exon Carn.xyltransf 103

444202 AL031685 Hs 12785 KIAA0939 protein Na_H Exchaπger,ABC2_membr 103

425597 U28694 Hs 158324 chemokine (C-C motif) rxeptor 7tm_1 103

413431 AW246428 Hs 75355 ubiquitm-conjugating enzyme E UQ_con 102

415200 AL040328 Hs 78202 SWI/SNF related, matπx ass∞i SNF2_N,helιcase C.bromodo 102

414874 D26351 Hs 77515 inositol 1,4,5-frιphosphate re RYDR_ITPR,ιon_trans,MIR 102

423524 AF055989 Hs 129738 potassium voltage-gated channe ιoπ_trans,K_tetra,thaumat 102

457558 AF083955 Hs 279852 G protein-coupled rxeptor 7tm_1,globιπ 102 445629 AI245701 Hs 193326 fibroblast growth fxtor rxep 101

434314 BE392921 Hs 3797 RAB26, member RAS oncogene fam ras.arf 101

402497 C1001261* gι|2695979|emb|CAA70 10 1

449853 AF006823 Hs 24040 potassium channel, subfamily K lonjrans 100

427672 AA356615 Hs 336916 death-ass∞iated protein 6 100

412048 AW866863 Hs 73090 nuclear fxtor of kappa light RHD,TIG,ank,death 100

410079 U94362 Hs 58589 glycogemπ 2 Glyco_transf_8 100

420319 AW406289 Hs 96593 hypothetical protein ras.arf 100

420332 NM.001756 Hs 1305 seπne (or cysteine) proteinas serpm 99

405474 NM 001093* Homo sapiens xetyl CPSase_L_chaιn,bιotm_lιp 99

401507 C15000810* gι|11131272|sp|P793 99

431434 BE267696 Hs 254105 enolase 1, (alpha) enolase 99

447232 AW499834 Hs 327 interieukin 10 rxeptor, alpha 98

432343 NM 002960 Hs 2961 S100 calcium-binding protein A S.100 98

408931 AA251995 Hs 334648 poly(A) polymerase alpha NTP_transf_2 98

421542 AA411607 Hs 118964 ESTs, Weakly similarto KIAA11 98

430323 U40714 Hs 239307 tyrosyl-tRNA synthetase DUF101 98

412270 AC005262 Hs 73797 guanine nucleotide binding pro G-alpha,arf 97

424649 BE242035 Hs 151461 embryonic xtoderm development WD40 97

400772 NM.003105* Homo sapiens sortil Idl_rxept_a,fn3,ldl_rxe 97

450493 M93718 Hs 166373 nitric oxide synthase 3 (endot flavodoxιn,FAD_bιndιng,NO 97

401510 NM.017434 Homo sapiens dual ox efhand.Femc.reduct 97

404596 Target Exon 97

451367 AA923729 Hs 26322 cell cycle related kinase pkinase 97

417810 D28419 Hs 82609 hydroxymethylbilane synthase Poφhobil deam 96

432855 AF017988 Hs 279565 sxreted fπzzled-related prot Fz,NTR 96

424263 M77640 Hs 1757 LI cell adhesion molxule (hyd fn3,ιg,IRK 96

430398 AF105202 Hs 241376 potassium voltage-gated channe ion trans,KCNQ1_channel 96

424339 BE257148 endoglycan MCM 96

429257 AW163799 Hs 198365 2,3-bιsphosphoglycerate mutase PGAM 96

407065 Y10141 gb H sapiens DAT1 gene, partia SNF 96

433938 AF161536 Hs 284292 ubiquinol-cytochrome c reducta 96

409649 AA159216 Hs 55505 hypothetical protein FLJ20442 Y_phosphatase DSPc 96

404968 C4001170 gι|6863176|gb|AAF3040 95

400833 Cl 1000890 gι|3746443|gb|AAC639 7tm_1 95

410191 AI609645 NM.021075* Homo sapiens NADH d 95

444633 AF111713 Hs 286218 junctional adhesion molxule 1 19 94

427747 AW411425 Hs 180655 seπne/threonme kinase 12 pkinase 94

415169 W42913 Hs 78089 ATPase, vxuolar, 14 kD ATP-synLF 94

432579 AF043244 Hs 278439 nucleolar protein 3 (apoptosis CARD 94

422328 X60459 Hs 1513 interferon (alpha, beta and om 94

445143 U29171 Hs 75852 casein kinase 1, delta pkinase 94

450883 NM.001348 Hs 25619 death-ass∞iated protein k as pkinase 94

414625 AA335738 Hs 76686 glutathione peroxidase 1 GSHPx 93

401935 Target Exon PH 93

418329 AW247430 Hs 84152 cystathionine-beta-synthase PALP.CBS 93

425242 D13635 Hs 155287 KIAA0010 gene product HECT.IQ 93

400404 AF161221 kallikrein 14 trypsin 92

442332 AI693251 Hs 8248 Target CAT fer2,molybdopteπn,bac_dn 92

431534 AL137531 Hs 258890 Homo sapiens mRNA, cDNA DKFZp4 92

402823 C1002456* gι|9930918|emb|CAC05 91

404527 peptide YY, 2 (semiπalplasmin) GDA1 CD39 9 1

439963 AW247529 Hs 6793 platelet-activating fxtor xe PAF-AH_lb,Lιpase_GDSL 91

412970 AB026436 Hs 177534 dual spxificity phosphatase 1 Rhodanese.DSPc 91

443553 AL040535 Hs 9573 ATP-binding cassette, sub-fami ABC Iran 91

400933 NM.004347 Homo sapiens caspase ICE p20,ICE_p10,CARD 90

403268 NM.002210* Homo sapiens integr FG-GAP 90

446673 NM.016361 Hs 15871 LPAP for lysophosphatidic xid xιd_phosphat 90

422531 AW967280 Hs 293894 ESTs, Weakly similar to HERC2 pkmase 90

421658 X84048 Hs 301760 frequenin (Drosophila) homolog efhand 90

401885 Target Exon kinesm 90

402651 NM.000721* Homo sapiens calciu lon.traπs 90

457432 NM.005136 Hs 268538 potassium voltage-gated channe ISK_Channel 90

433146 AB033002 Hs 21413 solute earner family 12, (pot 90

420090 AA220238 Hs 94986 πbonuclease P (38kD) RibosomalJ Ae 90

425281 AA444390 Hs 155482 hydroxyxyl glutathione hydrol Ixtamase.B 90

410855 X97795 Hs 66718 RAD54 (S cerevιsιae)-lιke SNF2_N,helιcase_C 90

407986 U32659 Hs 41724 interieukin 17 (cytotoxic T-ly 90

431131 N84730 Hs 250616 isocitrate dehydrogenase 3 (NA isodh 90

422802 NM 004278 Hs 27008 phosphatidylmositol glycan, c DUF158 90

447958 AW796524 Hs 68644 Homo sapiens microsomal signal 90

438080 AA777381 Hs 291530 ESTs, Weakly similar to ALUC.H 90

418843 AJ251016 Hs 89230 potassium intermediate/small c CaMBD,SK_channel 90

419244 AI436567 Hs 89761 ATP synthase, H transporting, ATP-synt.DE 89

404676 Target Exon 89

428744 BE267033 Hs 192853 ubiquitin-coπjugating enzyme E UQ_coπ 89

421474 U76362 Hs 104637 solute camerfamily 1 (gluta SDF 89

419056 M89957 Hs 89575 CD79B antigen (immunoglobulin- ig.lTAM 89

424825 AF207069 Hs 153357 procollagen-lysme, 2-oxogluta 20G-Fell_Oxy,Glycos trans 89

444628 U01120 Hs 242 glucose-6-phosphatase, catalyt PAP2 89

404199 ENSP00000211797* Helicase SKI2 RasGAP.PH 89

428826 AL048842 Hs 194019 atfrxtin lxtιn_c,CUB,Kelch,PSI,EG 89

410681 AW246890 Hs 65425 calbmdiπ 1, (28kD) efhand 88

415056 AB004662 Hs 77867 adenosmeAI rxeptor 7tm_1 88 400471 Target Exon 88

406591 NM_003888* Homo sapiens retina aldedh 88

425427 AI652662 Hs 157205 branched chain ammotransferas amιπofran_4 88

410839 NM 006849 Hs 66581 protein disulfide isomerase thιored,Rho_GDI,gntR 87

430037 BE409649 Hs 227789 mitogen-xtivated protein kma pkinase 87

450848 AI677994 Hs 428 fms-related tyrosine kinase 3 fltajig 87

414534 BE257293 Hs 76366 BCL2-antagonιst of cell death 87

401454 NM.014226* Homo sapiens renal pkinase 87

408493 BE206854 Hs 46039 phosphoglycerate mutase 2 (mus PGAM 87

433333 AI016521 Hs 71816 v-akt muπne thymoma viral one hom∞box,pkιnase,PH,pkma 87

430432 AB037758 Hs 241419 KIAA1337 protein Patched 87

406128 NM.002920* Homo sapiens regula Oest recep,zf-C4,hormoπe 87

419493 AF001212 Hs 90744 proteasome (prosome, mxropain PCI 87

439569 AW602166 Hs 222399 CEGP1 protein CUB.EGF 86

401134 C12001198 g ι(3183183[sp|Q92142 biopteππ.H 86

442286 W31847 Hs 50335 cytochrome P450 moπooxygenase 86

428376 AF119665 Hs 184011 pyrophosphatase (inorganic) Pyrophosphatase 86

433494 AB029396 beta-1,3-glucuronylfransferase Glyco_tranf_43 86

427001 NMJ06482 Hs 173135 dual-spxificity tyrosιπe-(Y)- pkinase 86

437278 AA748017 Hs 290145 ESTs cNMP.bindmg 86

414463 T69078 Hs 76177 alpha-1-mιcroglobulιn/bιkuπιn lιpocalιn,Kunιtz_BPTI 86

421871 AK001416 Hs 306122 glycoprotein, synaptic 2 Steroid.dh 86

447827 U73727 Hs 19718 protein tyrosine phosphatase, Y_phosphatase,fn3,ιg,MAM 86

403379 Target Exon DNA_pol_A 86

446872 X97058 Hs 16362 pyπmidinergic rxeptor P2Y, G 7tm_1 86

432857 NM 016103 Hs 279582 GTP-binding protein Sara arf.ras 85

420970 AA3~05079 Hs 1342 cytochrome c oxidase subunit V COX5B 85

427221 L15409 Hs 174007 von Hippel-Ltndau syndrome VHL 85

402209 Target Exon A2M.N.A2M 85

400518 C10002057* gι|3211705|gb|AAC21 85

425606 U52112 Hs 158331 renin-biπdmg protein 85

437965 AA843222 Hs 193534 ESTs, Moderately similar to AL RasGEF 85

433392 AF038535 Hs 127588 syπaptotagmin II C2 85

402191 NM.021733* Homo sapiens testis 85

458963 AI701393 Hs 278728 Rad and Gem related 2 (rat horn ras 85

431857 W19144 Hs 271742 ADP-πbosylfransferase (NAD, p PARP.PARP.reg 85

457579 AB030816 Hs 36761 HRAS like suppressor 85

409656 NM 005133 Hs 288626 RCE1, prenyl protein protease Abi 85

456373 BE247706 Hs 89751 membrane-spanning 4-domaιns, s 84

432499 BE276633 RAB6B, member RAS oncogene fam ras.arf 84

400565 Target Exon 84

401960 Target Exon Branch 83

432545 X52486 Hs 3041 uracil-DNA glycosylase 2 cyclin 83

445303 AW362198 Hs 12503 interieukin 15 rxeptor, alpha sushi 83

404528 peptide YY, 2 (seminalplasmin) GDA1.CD39 83

428542 D79989 KIAA0167 gene product ank.PH.ArfGap.ras 83

406868 AA505445 Hs 300697 immunoglobulin heavy constant 83

405473 NM.001093* Homo sapiens acetyl CPSase L.chain.biotin lip 83

408601 U47928 Hs 86122 protein A 7tm_1 83

415008 NM 002777 Hs 928 protemase 3 (senne proteinas tryps 83

430258 AU076644 Hs 236963 protein phosphatase 2A, regula 83

436483 AJ272063 Hs 283010 vanilloi rxeptor subtype 1 ank.ion.trans 83

459302 NM 002314 Hs 36566 UM domain kinase 1 83

437644 AA748575 Hs 136748 lectm-like NK cell rxeptor l∞tιn_c 83

421707 NM 014921 Hs 107054 lxtomedιn-2 Latrophιlιn,OLF,7tm_2,Gal 82

414629 AA345824 Hs 76688 carboxylesterase 1 (monocyte/m COesterase 82

453898 AW003512 Hs 232770 arxhidonate lipoxygenase 3 82

424053 AF057036 Hs 138520 collagen-like tail subunit (si Collagen 82

457398 BE258532 Hs 251871 CTP synthase GATase 82

421504 AW402997 Hs 105052 adaptor protein with plxkstπ SH2.PH 8 1

406495 Target Exon SRCR 8 1

453610 AW368882 Hs 33818 RxQ protein-like 5 DEAD.helicase.C 81

424880 NM 000328 Hs 153614 retmitis pigmentosa GTPase re RCC1 81

423847 U16997 Hs 133314 RAR-related orphan rxeptor C hormone_rec,zf-C4 8 1

409829 M33552 Hs 56729 lymphxyte-specific protein 1 Caldesmon 81

401180 eukaryotic translation elongat lon.trans.lQ 81

452072 BE25B857 Hs 27744 RAB3A, member RAS oncogene fam ras.arf 81

426484 AA379658 Hs 272759 KIAA1457 protein IP.traπs 8 1

402453 C1002496 gι|7363439|ref|NP 39 7tm_1 81

457310 W28363 Hs 239752 nuclear rxeptor subfamily 2, 8 1

422069 AJ010063 Hs 343603 titin-cap (telethonm) globiπ.cNMP.binding.pk a 81

400275 NM.006513* Homo sapiens seryl- NA 80

434357 AW732284 Hs 3828 mevalonate (diphospho) dxarbo GHMP.kmases 80

430299 W28673 Hs 106747 senne carboxypeptidase 1 prec 80

413762 AW411479 Hs 848 FK506-bιndιng protein 4 (59kD) FKBP.TPR 80

402393 ENSP00000085284* CDNA FU20404 RhoGEF.PH 80

429252 NM 004658 Hs 198312 RAS protein xtivatorlike 1 ( C2,PH,RasGAP,BTK 80

456181 L36463 Hs 1030 ras inhibitor RA.SH2.VPS9 79

431493 AI791493 Hs 129873 ESTs, novel cytochrome P450 p450 79

451558 NMJW1089 Hs 26630 ATP-binding cassette, sub-fami ABC_tran,SRP54 78

415758 BE270465 Hs 78793 protein kinase C, zeta pkιnase,DAG_PE-bιπd,pkιna 78

419270 NM 005232 Hs 89839 EphA1 EPH_lbd,pkιnase,SAM,fn3 78

422837 U25441 Hs 121478 dopamme receptor D3 7tm_1 78

401118 Target Exon pkinase 78 426440 BE382756 Hs.169902 solute carrier family 2 (fxil sugar.fr 7.8

418635 L11329 Hs.1183 dual spxificity phosphatase 2 DSPc,Rhodanese,Y_phosphat 7.8

432747 NM.014404 Hs.278907 calcium channel, voltage-depen PMP22_Claudin 7.8

403672 C4001244:gi|539933|pir||A61275 tubulin 7.8

437806 AI424921 Hs.122487 ESTs, Weakly similar to A54854 RasGAP 7.7

456890 U48213 Hs.155402 D site of albumin promoter (al DAGKcbZIP 7.7

424107 AB014606 Hs.139648 kinesin family member 1C kinesiπ.FHA 7.7

452695 AW780199 Hs.30327 mitogen-xtivated protein kina 7.7

433262 AI571225 Hs.284171 KIAA1535 protein cNMP.binding on.frans 7.7

424198 AB029010 Hs.143026 KIAA1087 protein Na_Ca_Ex,Calx-beta 7.6

406496 Target Exon SRCR 7.6

425423 NM.005897 Hs.157180 intrxisternal A particle-prom BTB,Kelch 7.6

402211 KIAA0430 gene product ion_trans,K_tetra 7.6

408710 Y10256 Hs.47007 mitogen-xtivated protein kina pkiπase.SAM.decarbox 7.5

457615 W56321 Hs.111460 calcium/calmodulin-dependent p pkinase 7.5

402760 NM_021797*:Homo sapiens eosino Glyco_hydro_18,CBM_14 7.5

425428 AL110261 Hs.157211 DKFZP586B0621 protein C1q, Collagen 7.4

423579 NM 004121 Hs.1675 gamma-glutamyltransferase-like G_glu traπspept 7.4

413104 L42374 Hs.75199 protein phosphatase 2, regulat B56 7.4

419660 BE280337 Hs.194693 solute carrier family 7 (catio aa_permeases 7.4

424774 BE244179 Hs.153022 TATA box binding protein (TBP) 7.4

402632 Target Exon Fz.kringle g 7.4

444159 AF116846 Hs.10431 dead ringer (Drosophila)-like ARID.SNF 7.4

405714 ENSP00000221137:Olfxtory rece 7tm_1 7.3

442732 AA257161 Hs.8658 hypothetical protein DKFZp434E EGF,lamiπin_EGF,Xliπk,S_m 7.3

421758 BE397336 Hs.1422 Gardner-Rasheed feline sarcoma SH2,SH3,pkinase 7.3

415995 NM.004573 phospholipase C, beta 2 PI-PLC-X,PI-PLC-Y,C2 7.3

405137 Target Exon 7.3

402460 C1001261*:gi|2695979|emb|CAA70 7.3

431398 BE616547 Hs.2785 keratin 17 filament 7.3

429592 AB029041 Hs.209646 KIAA1118 protein Troponin 7.3

429225 BE250337 Hs.198273 Target CAT 7.2

423015 U18548 Hs.123034 G protein-coupled receptor 12 7.2

454373 NM 005133 Hs.288626 RCE1, preπyl protein protease Abi 7.2

440188 AK001812 Hs.7036 N-Acetylglucosamine kinase ROK 7.2

432920 U37689 Hs.3128 polymerase (RNA) II (DNA dirx 7.2

446143 BE245342 Hs.306079 s∞61 homolog s∞Y 7.2

422201 NM.001505 Hs.113207 G protein-coupled rxeptor 30 7tm_1 7.2

440869 NM 014297 Hs.7486 protein expressed in thyroid Ixtamase B 7.1

435099 AC004770 Hs.4756 flap structure-specific endonu XPG_N,XPG_l,5_3_exonuclea 7.1

437161 AA054477 Hs.25391 ESTs 7.1

429683 AF148213 Hs.211604 a disintegrin-like and metallo tsp_1,Repralysin,Pep_M12B 7.1

426268 AF083420 Hs.168913 serine/threonine kinase 24 (St pkinase 7.1

445087 AW893449 Hs.12303 suppressor of Ty (S.cerevisiae S1,SH2,Ribosomal_L23,pkin 7.1

416377 AA179930 Hs.293867 caspase recruitment domain pro 7.1

421748 NM 014718 Hs.107809 KIAA0726 gene product cadherin 7.1

426691 NM.006201 Hs.171834 PCTAIRE protein kinase 1 pkinase 7.0

428599 AB033078 Hs.186613 sphingosine-1 -phosphate lyase pyridoxal.deC 7.0

411898 BE409714 Hs.44856 hypothetical protein FU12116 7.0

427010 AW138332 muscle RAS oncogene homolog ras 7.0

457305 BE268048 Hs.236494 RAB10, member RAS oncogene fam ras.arf 7.0

431630 NM.002204 Hs.265829 integrin, alpha 3 (antigen CD4 integrin_A,FG-GAP,Rhabd_g 7.0

457764 AW028284 Hs.4815 nudix (nucleoside diphosphate NUDIX 6.9

435575 AF213457 Hs.44234 triggering receptor expressed ig 6.9

456488 AW015098 Hs.301946 ESTs, Weakly similar to T30867 6.9

428761 AF236119 Hs.193076 GRB2-related adaptor protein 2 SH2.SH3 6.9

430396 D49742 Hs.241363 hyaluronan-binding protein 2 trypsiπ.kriπgle.EGF 6.9

422066 AW249275 Hs.343521 malate dehydrogenase 2, NAD (m ldh,ldh_C,adh_short,Semia 6.9

445937 AI452943 Hs.321231 UDP-Gal:betaGlcNAc beta 1,4- g Galxtosyl T 2 6.9

457499 AA953015 Hs.274370 hypothetical protein FU20260 PH 6.8

400845 NM_003105*:Homo sapiens sortil ldl_rxepLa,fn3,ldl_rece 6.8

416931 D45371 Hs.80485 adipose most abundant gene fra C1q,Collagen 6.8

414915 NM 002462 Hs.76391 myxovirus (influenza) resistan dynamin 2,dynamin,GED 6.8

432990 AL036071 Hs.279899 tumor n∞rosis fxtor rxeptor TNFR.C6 6.8

458128 W32474 Hs.301746 RAP2A, member of RAS oncogene ras.arfjdh 6.8

429542 AF03866O Hs.206713 UDP-Gal:betaGlcNAc beta 1,4- g Galxtosyl_T_2,ig 6.8

401488 Target Exon Glyco hydro 1 6.7

456243 AI345001 Hs.82380 menage a trois 1 (CAK assembly zf-C3HC4 6.7

424321 W74048 Hs.1765 lymphxyte-spxific protein ty SH2,SH3,pkinase 6.7

405187 NM_014272:Homo sapiens a disin Reprolysin.tsp 1,Pep M12B 6.7

413055 AV655701 Hs.75183 cytochrome P450, subfamily HE p450 6.7

448496 BE379077 Hs.130849 ESTs, Weakly similar to I38022 NADHdh_2 6.7

419667 AU077005 Hs.92208 a disintegrin and metalloprote disintegrin.Reprolysin.Pe 6.7

417103 Z33905 Hs.81218 hypothetical protein MGC3597 TPRzf-C3HC4,PHD 6.7

407687 AK002011 Hs.37558 hypothetical protein FU11149 FAD.Syπth 6.7

456469 NM 005109 Hs.95220 oxidative-stress responsive 1 zf-C2H2,pkinase 6.7

449546 W86248 Hs.58819 ESTs hexokinase 6.6

428926 NM.001702 Hs.194654 brain-specific angiogenesis in 7tm_2,tsp_1,GPS,HRM 6.6

404953 C1002000*:gi[12735712|ref|XP_0 6.6

449401 AL135401 Hs.23557 serologically defined colon ca pro isomerase 6.6

429962 M69113 Hs.226795 glutathione S-transferase pi GST.CGST.N 6.6

421547 AA489908 Hs.1390 proteasome (prosome, mxropain Clathriπ_lg_ch,proteasome 6.6

430035 NM 003463 Hs.227777 protein tyrosine phosphatase t Y_phosphatase,DSPc 6.6

406867 AA157857 Hs.182265 keratin 19 filament,bZIP 6.6 404946 Target Exon 3Beta_HSD 65

435213 AA092510 Hs 5985 non kinase Cdc42 effxtor prot 65

411201 T74588 Hs 8509 ESTs, Weakly similar to C3HU c A2M N.A2M 65

419344 U94905 Hs 277445 dixylglycerol kinase, zeta (1 ank,DAGKa,DAGKc,DAG_PE-bι 65

426194 T50872 Hs 2001 thromboxaπe A synthase 1 (plat p450 65

424681 AA054400 Hs 151706 KIAA0134 gene product helicase CPRK 65

417903 NM 002342 Hs 1116 lymphotoxin beta rxeptor (TNF TNFR.C6 65

408905 AV655783 Hs 661 Target CAT 65

438646 AI973076 Hs 231958 matπx metalloproteinase 28 65

431530 X61615 Hs 2798 leukemia inhibitory fxtor rec fn3 65

428883 AA436959 Hs 258802 ATPase, (Na)/K transporting, b Na.K-ATPase 65

404757 Target Exon 64

406370 interieukin 11 trypsin 64

443611 NM.014397 Hs 9625 NIMA (never in mitosis gene a) pkinase 64

424008 R02740 Hs 137555 putative chemokme receptor; G 7tm_1 64

444912 AW247380 Hs 12124 putative prostate cancer susce Ixtamase.B 64

454460 X66945 Hs 748 fibroblast growth fxtor rxep ig.pkmase 64

432269 NM.002447 Hs 2942 macrophage stimulating 1 recep pkmase,Sema,PSI,TIG,A4_E 64

458718 AI359476 Hs 157699 ESTs 64

405282 Target Exon Cxhe 64

447245 AK001713 Hs 17860 hypothetical protein FU10851 El.dehydrog 63

442297 NM.006202 Hs 89901 phosphodiesterase 4A, cAMP-spe PDEase 63

400894 C11000129 gι|9938014|ref|NP_06 7tm 1 63

440446 NM 013385 Hs 7189 plxkstπn homology, Sx7 and PH,Sx7 63

430886 L36149 Hs 248116 chemokme (C motif) XC recepto 7tm_1 63

451394 NM 003595 Hs 26350 tyrosylprotein sulfofransferas Sulfofransfer 63

436523 BE612990 Hs 5212 single strand setective monofu 63

422714 AB018335 Hs 119387 KIAA0792 gene product DUF221 63

408924 AW295606 Hs 236131 homxdomam-interxting protei 63

414551 AI815639 Hs 76394 enoyl Coenzyme A hydratase, sh ECH,Peptιdase_U7 63

413254 U40272 Hs 75253 is∞itrate dehydrogenase 3 (NA isodh 63

415010 NM 004203 Hs 77783 membrane ass∞iated tyrosine- pkinase 63

449761 AB009698 Hs 23365 solute earner family 22 (orga sugar.tr 63

432221 M21191 Hs 273415 aldolase A, fructose bisphosph glycolytιc_enzy,Adeno_E3_ 63

414513 AW239400 Hs 76297 G protein-coupled rxeptor km pkιnase,RGS,pkιnase_C 62

458516 BE010749 Hs 255097 ESTs 62

417985 AA187545 Hs 83114 crystallin, zeta (qumoπe redu adh.ziπc 62

447507 H59696 Hs 18747 POP7 (processing of precursor, 62

418322 AA284166 Hs 84113 cyclin-dependent kinase inhibi Y_phosphatase,DSPc 62

428443 BE618106 Hs 184326 CDC10 (cell division cycle 10, GTP.CDCM 62

423229 AC003965 Hs 125532 protease, senne, 26 trypsin 62

408903 BE244377 Hs 48876 farnesyl-diphosphate farnesylt SQS PSY,dsrm,z-alpha 62

426176 AB000462 Hs 167679 SH3-domaιn binding protein 2 PH.SH2 6 1

421395 D90084 Hs 1023 pyruvate dehydrogenase (lipoam E1 dehydrog 6 1

430517 S80071 Hs 241597 solute earner family 6 (neuro SNF 6 1

435906 AI686379 Hs 110796 SAR1 protein arf.ras 6 1

402758 C1001899* gι|12722636|ref|XP_0 Glyco_hydro_18 6 1

434202 BE382411 Hs 3764 guanylate kinase 1 Guanylate kin.CoaE.Viral 61

402115 NM.021624 Homosapiens histami 7tm 1 61

407601 AC002300 Hs 37129 sodium channel, nonvoltage-gat ASC 61

404679 Target Exon 60

450739 AI732707 ESTs, Weakly similar to ALU7.H V1R 60

439888 AB040949 Hs 6733 pancreas-enπched phospholipas C2,PI-PLC-Y,PI-PLC-X,RasG 60

415742 BE410243 Hs 78769 thimetoligopeptidase l Peptιdase_M3 60

453190 AB002354 Hs 32312 KIAA0356 gene product PH.PHD.RUN 60

439975 AW328081 Hs 6817 inosme tnphosphatase (nucleo Hamlp.like 60

412800 AW950852 Hs 74598 polymerase (DNA dirxted), del hom∞box 60

432805 X94630 Hs 3107 CD97 antigen 7tm 2.GPS.EGF 60

418964 T74640 gb yc57c12 r1 Stratagene liver A2M.N.A2M 60

417483 BE549343 Hs 82208 xyl-Coenzyme A dehydrogenase, Acyl-CoA_dh,Acyl-CoA dh M 60

419755 H18444 Hs 134846 BAI1-ass∞ιated protein 3 C2 60

457276 AF235097 Hs 227583 Homo sapiens chromosome X map 60

423908 AJ006422 Hs 135183 centauπn-alpha PH,ArfGap 60

432118 N98718 gb yy65g02 r1 Soares.multiple. 59

427334 R44789 Hs 33191 Homo sapiens, Similar to trans 59

424959 NM 005781 Hs 153937 xtivated p21cdc42Hs kinase pkιnase,SH3 59

453082 H18835 Hs 31608 hypothetical protein FU20041 ion trans 59

421168 AF182277 Hs 330780 cytochrome P450, subfamily IIB p450 59

422287 F16365 Hs 114346 cytochrome c oxidase subunit V COX7a,Phage_G 59

401736 C16000492* gι|3127193lgb|AAD05 AMP-bindmg 59

434755 AA648502 ESTs 59

414962 AF273304 Hs 235376 XPMC2 protein Exonuclease 58

407338 AA773213 gb ab66f10 s1 Stratagene lung ig 58

448426 BE018315 Hs 280776 tankyrase, TRF1-ιnterxtιng an 58

409686 AK000002 Hs 55879 Homo sapiens mRNA, cDNA DKFZp4 ABC.fran 58

450778 U81375 Hs 25450 solute camerfamily 29 (nucl Nucleoside.tran 58

423612 NM 002067 Hs 1686 guanine nucleotide binding pro G-alpha,arf 58

430845 AF024690 Hs 248056 G protein-coupled rxeptor 43 7tm_1 58

424741 AF051941 Hs 343824 nucleoside diphosphate kinase NDK 58

412958 BE391579 Hs 75087 Fas-xtivated seπne/thr∞nme 58

415701 NM 003878 I Hs 78619 gamma-glutamyl hydrolase (conj GATase 58

423158 H97991 Hs 193313 Target CAT MoaA_NιfB_PqqE 58

414788 X78342 Hs 77313 cyclin-dependent kinase (CDC2- pkinase 58

412915 AW087727 Hs 74823 NM.004541 Homo sapiens NADH de 57 420904 AL035964 Hs 100221 nuclear receptor subfamily 1, hormoπe_rx,zf-C4 57

415503 U36601 Hs 78473 N-dexetylase/N sulfofransfera Sulfotraπsfer 57

433074 AL045019 Hs 323462 Homo sapiens cDNA FU11214 fis DEAD,helιcase_C,dsrm,Vira 57

409124 AW292809 Hs 50727 N xetylglucosaminidase, alpha 57

428270 BE501549 Hs 107040 ESTs 57

435114 AA775483 Hs 288936 mitochondnal πbosomal protei ODC.AZ 57

425211 M18667 Hs 1867 progastπcsin (pepsmogen C) asp 57

453054 AI878808 Hs 31547 Target CAT 57

420730 NM 002691 Hs 99890 polymerase (DNA directed), del ICL 57

415117 AF120499 Hs 78016 polynucleotide kinase 3'-phosp Viral.helicasel 57

400985 Target Exon 57

413163 Y00815 Hs 75216 protein tyrosine phosphatase, fπ3,ιg,Y_phosphatase 57

413858 NM 001610 Hs 75589 xid phosphatase 2, lysosomal xid phosphat 57

457308 AI416988 Hs 238272 mositol 1,4,5-tnphosphate re ion trans,RYDR ITPR.MIR 57

400551 C10001991* gι|6624920|emb]CAB6 SRCR 57

433472 AI541246 Hs 3343 phosphoglycerate dehydrogenase 2-Hxιd_DH,2-Hxιd_DH_C,M 57

409531 BE384319 Hs 54702 xylosylprotein beta1,4-galxto Galxtosyl_T_2 57

449139 BE268315 Hs 23111 phenylalanine-tRNA syπthetase- πeur 57

450207 T87615 Hs 14716 ESTs 57

400266 NM.002858* Homo sapiens ATP-bi ABC traπ 56

430713 AA351647 Hs 2642 eukaryotic translation eloπgat GTP EFTU.GTP EFTU D3.GTP 56

420911 U77413 Hs 100283 O linked N-xetylglucosamine ( TPR 56

405683 Target Exon 56

449181 X96783 Hs 23179 synapfotagmin V C2 56

414457 AW514320 Hs 76159 ATPase, H transporting, lysoso ATP-syπLC 56

415193 AL048891 Hs 12185 hypothetical protein MGC14333 56

434883 AW381538 Hs 19807 hypothetical protein MGC12959 56

433135 AA443873 Hs 110477 dolichyl-phosphate maπnosyltra 56

413049 NM.002151 Hs 823 hepsm (transmembrane protease trypsin 56

420899 NM.001629 Hs 100194 arxhidonate 5-lιpoxygenase-ac MAPEG 56

423397 NM 001838 Hs 1652 chemokine (C-C motif) rxeptor 7tm_1 55

443759 BE390832 Hs 134729 FXYD domain-containing ion fra 55

454112 NM.000885 Hs 40034 integπn, alpha 4 (antigen CD4 ιntegπn_A,FG-GAP 55

405594 NM.021949 Homo sapiens ATPase, E1-E2_ATPase,Hydrolase 55

416322 BE019494 Hs 79217 pyrrolιne-5-carboxylate reduct P5CR,Octopιne_DH_N 55

446755 AW451473 Hs 16134 seπne/threonme kinase 10 pkmase.TYA 55

411030 BE387193 Hs 67896 7-60 protein 55

431498 AK001777 Hs 258551 aspartyl aminopeptidase Peptidase M18 55

433012 NM.004045 Hs 279910 ATX1 (antioxidant protein 1, y HMA 55

414907 X90725 Hs 77597 polo (Drosophιa)-lιke kinase pkmase.POLO.box 55

424572 M19650 Hs 92909 2',3'-cyclιc nucleotide 3' pho 55

406617 Target Exon efhand.Fernc.reduct 55

421883 X55079 Hs 1437 glucosidase, alpha, xid (Pomp trefoιl,Glyco_hydro_31 54

419525 T79257 Hs 1259 asialoglycoprotein rxeptor 2 lectm.c 54

448093 AW977382 Hs 15898 2,4-dιenoyl CoA reductase 2, p adh.short 54

411574 BE242842 Hs 6780 protein tyrosine kinase 9 like cofilin.ADF 54

406432 CD1E antigen, e polypeptide Sulfofransfer 54

428921 Z43809 Hs 194638 polymerase (RNA) II (DNA direc 54

430337 M36707 Hs 239600 calmodulin-like 3 efhand 54

427162 AB011133 Hs 173864 KIAA0561 protein pkmase.PDZ 54

414216 D86970 Hs 75822 TGFB1-ιnduced aπti-apoptotic f oxιdored_q4,myosιπ_head,b 54

422083 NM 001141 Hs 111256 arxhidonate 15-lιpoxygenase, lipoxygenase.PLAT 54

424373 AJ133798 Hs 146219 copine VII C2 54

449405 AA001350 gb zh83h05 r1 Soares.fetal.liv mito carr 54

409983 D50922 Hs 57729 Kelch-like ECH-assxiated prot BTB.Kelch 54

455818 AI733747 Hs 71174 interieukin 21 rxeptor 54

424357 AW961058 Hs 44856 hypothetical protein FU12116 54

423606 AB011094 Hs 129892 KIAA0522 protein PH,bZIP,IQ,Sec7 53

432311 BE083080 Hs 274323 similar to sialyltransferase 7 Glyco fransf_29 53

450080 AB037831 Hs 24372 ESTs, Weakly similar to dJ207H DEAD.GSPILE 53

423778 Y09267 Hs 132821 flavin containing monooxygenas FMO-lιke,pyr_redox 53

402338 Target Exon p450 53

412276 BE262621 Hs 73798 mxrophage migration inhibitor MIF 53

437967 BE277414 Hs 5947 mel transforming oncogene (der ras.arf 53

424766 BE388855 Hs 152878 proteaseome (prosome, mxropai PA28_alpha.PA28.beta 53

447766 NM 016011 Hs 19513 CGI-63 protein adh_zmc 53

453660 X98507 Hs 286226 myosin IC myosin head.lQ 52

435327 BE301871 Hs 4867 mannosyl (alpha-1,3-) glycopro HLH,Myc_N_term,Myc-LZ 52

432336 NM 002759 Hs 274382 protein kinase, interferon-iπd dsrm.pkmase 52

445139 AB037848 Hs 12365 synaptotagmin XIII C2 52

429214 AB012722 Hs 198256 kinesin-like 3 kinesm 52

432462 AK000013 Hs 274701 thymidine kinase 2, mitochondr dNK 52

424387 AI739312 Hs 284163 ANKHZN protein 52

405697 gb Human homxbox-like mRNA 52

450321 Y16521 Hs 24812 CDP-dixylglycerol synthase (p Cytidylyltraπs.Adeno VII 51

412939 AW411491 Hs 75069 eukaryotic translation elongat SHMT 51

445109 AF039916 Hs 12330 xtoπucteoside tπphosphate di GDA1 CD39 51

419073 AW372170 Hs 183918 Homo sapiens cDNA FU12797 fis ιg,tsp_1,ZU5 51

409958 NM.001523 Hs 57697 hyaluronan synthase 1 Glycos transf_2 5 1

442599 AF078037 Hs 324051 RelA-associated inhibitor SH3,aπk 51

424305 BE386095 Hs 112272 histone dexetylase 8 HisLdexetyl 51

427247 AW504221 Hs 174103 integπn, alpha L (antigen CD1 vwa integnn A.FG-GAP 51

429061 Y14039 Hs 195175 CASP8 and FADD-like apoptosis DED,ICE_p20 51

420849 X52221 Hs 99987 excision repair cross-compleme 51 453337 R73417 Hs 25391 gb yj92g12 r1 Soares breast 2N GSPII III 51

418910 Z25821 Hs 89466 Homo sapiens, Similar to dodx ECH 5 1

425771 BE561776 Hs 159494 Brutoπ agammaglobulinemia tyro SH2,SH3,pkιnase,PH,BTK 51

405202 NM.021734* Homo sapiens d∞xyn mito.carr 51

451452 BE560065 Hs 26433 dolichyl-phosphate (UDP-N xet Glycos transf 4 50

418231 AA326895 Hs 83848 tπosephosphate isomerase 1 TIM 50

425165 NM 014434 Hs 154899 Target CAT 50

407876 NM 004519 Hs 40866 potassium voltage-gated channe ιon_frans,KCNQ1_channeI 50

417831 H16423 Hs 82685 CD47 antigen (Rh related antig ig 50

404716 NM.007313* Homo sapiens v-abl SH2,SH3,pkιnase 50

405020 Target Exon 7tm_1 50

426236 NM 004798 Hs 168212 kinesm family member 3B kinesm 50

433178 AB038269 Hs 253706 cysteinyl leukotπene CysLT2 r 7tm_1 50

422340 AW296219 Hs 115325 RAB7, member RAS oncogene fami arf.ras 50

439414 NMJ01183 Hs 6551 ATPase, H transporting, lysoso 50

425846 AA102174 Hs 159629 myosin IXB myosιn_head,DAG_PE-bιnd,l 50

413599 AJ006239 Hs 75438 qumoid dihydropteπdine reduc adh short 50

424168 L29277 Hs 321677 signal transducer and xtivato SH2,STAT,STAT_bιnd,STAT_p 50

436042 AF284422 Hs 119178 cation-chloπde cotransporter- aa_permeases 50

410775 AB014460 Hs 66196 nth (E coli endonuclease III)- HhH GPD 50

428734 BE303044 Hs 192023 eukaryotic translation initial WD40 50

420340 NM.000734 Hs 97087 CD3Z antigen, zeta polypeptide ITAM 49

433075 NM 002959 sortilm 1 BNR 49

400300 X03363 HER2 rxeptor tyrosine kinase pkinase 49

426811 BE259228 Hs 172609 nucleobiπdm 1 efhand 49

401577 NM.000761 Homo sapiens cytxhr p450 49

409637 AA323948 Hs 55407 Homo sapiens mRNA, cDNA DKFZp4 Collagen 49

426831 BE296216 Hs 172673 S-adenosylhom∞ysleme hydrola AdoHcyase 49

430904 U65402 Hs 248124 G protein-coupled rxeptor 31 7tm_1 49

423552 AF107028 Hs 129783 sodium channel, voltage-gated, ιg,Adeno_E3_CR2 49

421487 AF027406 Hs 104865 senne/threonme kmase 23 pkmase 49

402183 NM.004491* Homo sapiens glucoc FF 49

456748 AW137749 Hs 125902 ubiquitin specific protease 2 UCH-1.UCH 2 49

424771 BE397151 Hs 153003 senne/threonme kinase 16 pkinase 49

406441 Target Exon Aa.frans 49

437053 AU077018 Hs 3235 keratin 4 filament,bZIP,Tropomyosιn 49

443044 N28522 Hs 8935 quinoliπafe phosphoπbosyltran QRPTase,QRPTase_N 49

431204 F28841 Hs 250760 cytxhrome c oxidase subunit V dUTPase,COX6A,ras,ATP-syn 49

456417 L36531 Hs 91296 integπn, alpha 8 ιntegπn_A,FG-GAP 48

436735 L48489 mannosyl (beta-1,4-)-glycoprot 48

441455 AJ271671 Hs 7854 zinc/iron regulated transporte Zip 48

446948 BE409053 Hs 299629 peroxisomal long-chain xyl-co 48

451564 AU076698 Hs 132760 hypothetical protein MGC15729 sugar.tr.Condensation 48

403771 NM.003061 Homo sapiens slit (D EGF.Iaminm G,LRR,LRRNT,L 48

403248 ESTs, Weakly similar to I78885 SLT 48

410214 L29555 Hs 301698 sialyltransferase 4A (beta-gal Glyco_fransf_29 48

407047 X65965 gb H sapiens SOD-2 gene for ma sodfe 48

422668 AF199364 Hs 119120 E3 ubiquitin ligase SMURF1 C2,WW,HECT 48

436057 AJ004832 Hs 5038 neuropathy target esterase cNMP.bindmg 48

431262 NM 006672 Hs 251395 solute earner family 22 (orga sugar.tr 48

406625 Y13647 Hs 119597 stearoyl-CoAdesaturase (delta FA.desaturase 48

428659 U66579 Hs 188859 G protein-coupled rxeptor 20 48

432716 AI762964 Hs 205180 ESTs 48

414460 L00727 Hs 898 dystrophia myotonica-protem k pkinase 48

400287 S39329 Hs 181350 kallikrein 2, prostatic trypsin 48

428946 D42046 Hs 194665 DNA2 (DNA replication helicase UvrD helicase.Vira l.helic 47

420028 AB014680 Hs 8786 carbohydrate (N-xetylglucosam Sulfotransfer 47

402912 Target Exon pkinase 47

443329 BE262943 Hs 9234 hypothetical protein MGC1936 47

426120 AA325243 Hs 166887 copine I C2 47

430609 AA302921 Hs 247362 dimethylarginine dimethylamino 47

451320 AW118072 dixylglycerol kinase, zeta (1 zf-C2H2,BAR SH3 47

447131 NM.004585 Hs 17466 retmoic xid rxeptor respond 47

431222 X56777 Hs 273790 zona pellucida glycoprotein 3A zona_peIlucιda 47

406458 C14000133* gι|1082739|pιr||C44 proteasome 47

427804 AL049654 Hs 180871 protein kinase C, alpha bindm PDZ 47

450748 AI733093 Hs 247686 ESTs 7tm_1 47

422937 U03270 Hs 122511 centπn, EF-hand protein, 1 efhand 47

407978 AW385129 Hs 41717 phosphodiesterase 1A, calmodul PDEase 47

428773 BE256238 Hs 193163 bπdging integrator 1 SH3.BAR 47

456444 AA884517 Hs 31856 ESTs, Weakly similar to KIAA14 47

405574 Target Exon pkinase 47

442414 BE408758 Hs 8297 πbonuclease 6 prxursor πbonuclease_T2 47

418289 AW403103 Hs 83951 Hermaπsky-Pudlak syndrome 46

421601 AI660190 Hs 106070 cyclin-dependent kinase inhibi GDI 46

422795 AB033109 Hs 120866 KIAA1283 protein kazal,A2M,A2M N 46

433019 AI208513 Hs 279915 fransl∞ase of inner mitochond zf-Tιm10_DDP 46

431522 AI625859 Hs 258609 protein tyrosine phosphatase, fn3,Y_phosphatase 46

400846 sortlin-related rxeptor, L(D Idl recepLa,fn3,ldl rxe 46

456881 AW028302 Hs 155079 protein phosphatase 2, regulat B56 46

418172 X61157 Hs 83636 adrenergic, beta, receptor km pkιπase,PH,RGS 46

408433 AW162931 Hs 45002 ras related C3 botuliπum toxin ras 46

439921 AL110209 Hs 6770 LCAT-like lysophospholipase LACT 46

427122 AW057736 Hs 323910 HER2 rxeptor tyrosine kinase pkinase.Fuπn hke.Rxep. 46 427945 AW137156 Hs 181202 hypothetical protein FU 10038 Collagen 46

451777 U09210 Hs 459 solute camerfamily 18 (vesi sugar fr 46

429938 BE296804 Hs 226377 phosphate cytidylyltransferase Cytιdylylfransf,COX6C 46

412974 R18978 Hs 75105 emopamil-bmding protein (ster 46

414702 L22005 Hs 76932 cell division cycle 34 UQ_coπ 46

425795 AJ000479 Hs 159543 endothelial differentiation, G 7tm_1 46

422454 U49070 Hs 161362 protein (peptidyl-pralyl cis/t Rotamase.WW 46

408135 AA317248 Hs 42957 methyltransferase like 1 Methylfransf_4 46

457388 AFO35300 Hs 264157 cadheπn-like 22 cadheπn.Cadheπn.C.term 46

421140 AA298741 Hs 102135 signal sequence rxeptor, delt Herpes_UL3 46

434834 AF156774 Hs 324020 1-xylglycerol-3-phosphate O-a Acylfransferase 46

413407 AI356293 Hs 75339 inositol polyphosphate phospha SH2.SAM 46

402463 NM.014624 Homo sapiens S100 ca efhaπd,S_100 45

417891 W79410 Hs 82887 protein phosphatase 1, regulat 45

421681 AA384922 Hs 195175 CASP8 and FADD-like apoptosis ICE_p20,DED 45

426516 BE262660 Hs 170197 glutamic-oxaloxetic fransamm amιπofran_1_2 45

418963 BE304571 Hs 89529 aldo-keto reductase family 1 , aldo.keLred 45

423664 NM 004714 Hs 130988 dual-spxificity tyrosιne-(Y)- pkinase 45

427681 AB018263 Hs 180338 tumor nxrasis fxtor rxeptor TNFR_c6,death,PH,Xlιnk,Rh 45

432893 NM 016154 Hs 279771 Homo sapiens clone PP1596 unkn ras.arf 45

413815 AL046341 Hs 75562 discoidm domain rxeptor fami F5_F8_type_C,pkιnase 45

405546 NM.018833* Homo sapiens transp ABC.membrane.ABC.tran 45

416297 AA157634 Hs 79172 solute earner family 25 (mito mito.carr 45

421962 D82061 Hs 288354 FabG (beta-ketoxyl [xyl-carr adh.short 45

415341 R00602 gb ye74e04 r1 Soares fetal liv pkinase 45

456668 W81526 Hs 118329 ESTs, Moderately similar to GA Neur.chan.LBD.Neur.chan.m 45

456652 AW327546 Hs 111024 solute earner family 25 (mito mito.carr 45

407863 AA317089 Hs 597 glutamic-oxaloxetic fransamm amιnofran_1_2 45

435891 AW249394 Hs 5002 copper chaperone for superoxid sodcu.HMA 45

453997 AW247615 Hs 37003 v-Ha ras Harvey rat sarcoma vi ras 45

449029 N28989 Hs 22891 solute camerfamily 7 (catio aa_permeases 45

424829 NM 002507 Hs 1827 nerve growth fxtor rxeptor ( death,TNFR_c6 45

429362 T25833 Hs 200478 ubiquitm-coπjugating enzyme E UQ_con 45

429133 N31854 Hs 197116 solute earner family 7 (catio aa_permeases 45

426079 D31220 Hs 166168 peter pan (Drosophila) homolog 7tm_1 44

414814 D14697 Hs 77393 farnesyl diphosphate synthase polyprenyl.synt 44

433261 AB040967 Hs 112034 KIAA1534 protein PH,Oxysterol_BP 44

402915 ENSP00000202587* Bicarbonate t HC03_cotransp 44

418267 BE389537 Hs 83919 glucosidase I Glyco_hydro_63 44

430716 BE387257 Hs 247831 Homo sapiens, Similar to myosi efhand 44

420874 X66357 Hs 336478 cyclin-dependent kinase 3 pkinase 44

439902 AF174499 Hs 6764 histone deacetylase 6 HιsLdexetyl,zf-UBP 44

400223 Eos Control Skp1 44

450611 NM.004405 Hs 419 distal-less homeo box 2 homxbox 44

412965 L06419 Hs 75093 procollageπ-tysine, 2-oxogluta 20G-Fell_Oxy 44

435564 AF210652 Hs 16614 5(3) deoxyπbonucl∞tidase (dN 44

416121 X92762 Hs 79021 tafazzm (cardiomyopathy, dila Acylfransferase 44

423323 AI951628 Hs 127007 potassium channel, subfamily K lon.frans 44

448191 NM 005881 Hs 20644 branched chain alpha-ketoxid HATPase.c 44

456217 BE253181 Hs 81687 non metastatic cells 3, protei NDK,Arteπ_glycop 44

436415 BE265254 Hs 343258 proliferation-ass∞iated 2G4, Peptιdase_M24 44

429218 AA225065 Hs 198269 Target CAT 44

407433 AF209923 gb Homo sapiens orphan G-prote 7tm_3 44

425955 T96509 Hs 248549 ESTs, Moderately similar to S6 44

407230 AA157857 Hs 182265 keratin 19 filameπt,bZIP 43

410197 NM 005518 Hs 59889 3-hydroxy-3 methylglutaryl-Coe HMG_CoA_synt 43

416409 R61573 Hs 79300 ubiquitin-conjugatmg enzyme E UQ_con 43

447957 NM 014821 Hs 20126 KIAA0317 gene product Fιlamιn,HECT 43

421771 NM 001224 Hs 108131 caspase 2, apoptosis-related c ICEj>20,CARD,ICE_p10 43

448886 AL137291 Hs 22451 hypothetical protein FU10357 PH.RhoGEF 43

414821 M63835 Hs 77424 Fc fragment of IgG, high affiπ ig 43

431096 AA324358 Hs 249227 Homo sapiens DNA, cosmid clone 43

429892 NM 003803 Hs 2504 myomesin 1 (skelemiπ) (185kD) ιg,fn3 43

450126 BE018138 Hs 24447 Sigma rxeptor (SR31747 biπdiπ 43

413781 J05272 Hs 850 IMP (inosme monophosphate) de IMPDH CIMPDH N.CBS.NPD 43

406530 NM.005546* Homo sapiens IL2-ιn SH2,SH3,pkιnase,PH,BTK 43

428363 AK000284 Hs 183860 hypothetical protein FU20277 GNT-I 43

413954 AL037111 Hs 75641 galactose-1-phosphate uπdylyl GaIP_UDP_transf,GalP_UDP_ 43

432179 X75208 Hs 2913 EphB3 EPH_lbd,fn3,pkιnase,SAM 43

456529 AF014643 Hs 100072 connexιn466 connexin 43

448988 Y09763 Hs 22785 gamma-aminobutyπc xid (GABA) Neur chan LBD.Neur chaπ m 43

426626 AI124572 Hs 323879 inhibitor of kappa light polyp zf-C2H2 43

432956 AL037895 Hs 279861 CGI-31 protein thiored 43

428970 BE276891 Hs 194691 retmoic xid induced 3 7tm 3 43

428953 AA306610 Hs 348183 tumor nxrosis fxtor rxeptor TNFR.C6 42

423922 AK001663 Hs 135458 muscle-spxific beta 1 integn 42

426613 U96132 Hs 171280 hydroxyxyl-Coenzyme A dehydro adh.short 42

426566 AF131836 Hs 170453 tropomodulm Tropomodulm.pkinase 42

425179 AJ224442 Hs 155020 putative methyltransferase 42

412715 NM 000947 ' Hs 74519 pπmase, polypeptide 2A (58kD) 42

459298 R86701 gb ym86d09 r1 Soares adult bra 42

404879 NM.030807 Homo sapiens glucose 42

400836 Target Exon Apolipoprotein 42

430940 Z25470 Hs 248145 melanocortm 5 rxeptor 42 400563 Target Exon Pep_M12B_propep 42

430237 AI272144 Hs 236522 DKFZP434P106 protein abhydrolase 42

425175 AF020202 Hs 155001 UNC13 (C elegaπs)-lιke DAG_PE-bιnd,C2 42

409067 BE260459 Hs 50267 putative GTP-bmding protein s ras 42

419982 AA252544 Hs 55610 solute camerfamily 30 (zinc 42

428394 AU076472 Hs 184141 glutaryl-Coenzyme A dehydrogen Acyl CoA_dh,Acyl-CoA_dh_M 42

437696 Z83844 Hs 5790 hypothetical protein dJ37E165 Hydrolase 42

454034 NM 000691 Hs 575 aldehyde dehydrogenase 3 famil aldedh 42

410237 AI750589 Hs 61258 arginiπosuccinate lyase lyase 1 4 1

451478 NM 012331 Hs 26458 methionine sulfoxide reductase PMSR 41

415410 AF037332 Hs 278569 sorting nexin 17 PX,fn3,pkιnase,SAM,EPH_lb 41

406538 Target Exon trypsin 41

424349 AF141289 Hs 145550 solute earner family 7 (catio aa_permeases 41

441164 AB023180 Hs 7724 KIAA0963 protein helicase.C 4 1

421318 U63973 Hs 103501 rhodopsm kinase pkinase.pkmase.CRGS 41

439340 AB032436 Hs 6535 brain-specific Na-depeπdent in sugar_fr,BT1 4 1

417447 N73703 Hs 293267 ESTs Glyco hydro 31 4 1

409693 AA010233 Hs 55921 glutamyl prolyl-tRNAsynthetas WHEP-TRS,GST CHGTP.antic 41

403655 NM.003071 Homo sapiens SWI/SNF SNF2_N,helιcase_C,zf-C3HC 41

411142 NM 014256 Hs 69009 transmembrane protein 3 GalxtosyLT 41

437016 AU076916 Hs 5398 guanine monphosphate syπthetas GMP synLC.GATase 41

422699 BE410590 Hs 119257 emsl sequence (mammary tumor a SH3,HS1_rep 4 1

427202 BE272922 Hs 173936 interieukin 10 rxeptor, beta Tissue fx 41

421380 D31833 Hs 1372 argimne vasopressm rxeptor 7tm_1 4 1

434142 U47927 Hs 3759 ubiquitin specific protease 5 zf-UBP,UCH-2,UBA,UCH-1 41

427407 BE268649 Hs 177766 ADP-πbosyltransferase (NAD, p BRCT,PARP,zf-PARP,PARP_re 4 1

413749 AI929320 Hs 75516 tyrosine kinase 2 pkinase 41

411927 BE274009 Hs 772 glycogen synthase 1 (muscle) Glycos transf 1 41

419726 U50330 Hs 1274 bone morphogenetic protein 1 EGF,CUB,Astxιn 41

423814 AF105020 Hs 132989 putative protein O maπnosylfra PMT.MIR 41

451355 NM 004197 Hs 444 senne/threonme kinase 19 41

422556 NM.006245 Hs 118244 protein phosphatase 2, regulat B56 41

428284 AA535762 Hs 183435 NM 004545 Homosapiens NADH de 41

431968 AF117222 Hs 272261 UDP-Gal betaGlcNAc beta 1,3-ga GalxtosyLT 40

443639 BE269042 Hs 9661 proteasome (prosome, mxropain proteasome 40

410039 AF207989 Hs 58014 Homo sapiens, Similar to G pro 7tm_3 40

431066 AF026273 Hs 249175 ιnterleukιn-1 receptor-ass∞ia pk ase.death 40

452715 Z21093 Hs 30352 πbosomal protein S6 kinase, 5 pkinase 40

403692 NM.007037* Homo sapiens a disi Reprolysin.tsp 1,Pep M12B 40

442549 AI751601 Hs 8375 TNF rxeptor-assxiated fxtor zf-C3HC4,MATH zf-TRAF 40

427239 BE270447 ubiquitin earner protein UQ_con 40

451125 AA015779 Hs 226923 ESTs Y_phosphatase 40

425081 X74794 Hs 154443 minichromosome maintenance def MCM 40

402171 Target Exon C2 40

402665 Target Exon 40

420148 U34227 Hs 95361 myosin VIIA (Usher syndrome 1 B myosin head.lQ MyTH4,SH3, 40

412187 U68487 Hs 73739 5-hydroxytryptamιne (serotonin 7tm 1 40

412656 AF006011 Hs 74375 dishevelled 1 (homologous to D PDZ,DEP,DIX,Dιshevelled 40

425786 U35234 Hs 159534 protein tyrosine phosphatase, fn3,ιg,Y_phosphatase,DSPc 40

424288 AW137198 Hs 278682 Phosphatidylglycerophosphate S 40

452230 AW135360 Hs 224170 ESTs pkinase 40

408449 NM 004408 Hs 166161 dyna in 1 PH,GED,dynamιn,dynamm_2 40

423883 AF250238 Hs 134514 ATP-binding cassette, sub-fami ABC tran,photoRC,SRP54,Ca 40

422676 D28481 Hs 1570 histamme receptor H1 7tm 1 40

458639 BE247683 Hs 14611 dual specificity phosphatase 1 DSPc 40

400726 C13000717* gι|129376|sp|P26196 DEAD.helicase.C 40

405370 NM.005569* Homo sapiens UM do pkιnase,LIM,PDZ 40

413654 AA331881 Hs 75454 peroxiredoxiπ 3 AhpC-TSA 40

432917 NM 014125 Hs 241517 PRO0327 protein 40

448362 AA641767 Hs 21015 hypothetical protein DKFZp564L . sugar.tr 40

424512 X53002 Hs 149846 integπn, beta 5 integπn.B.EGF 40

TABLE 22B

Pkey Unique Eos probeset identifier number CAT number Gene cluster number

Accession Genbank xcession numbers

Pkey CAT Number Accession 410191 11824.1 AI609645 AI81820 AA948024 AI278970 AA688Q86 AA858279 F21973 W95840 AW969644 X99726 AA431579 AA970887 AI885085 A1767835

BE566516 AA725824 AI000871 AW242322 AW007204 W68289 AA431450 AW466973 BE222544 AA483454 AI968050 W95975 AI381017

AA776726 AI040976AA89

415341 1534442.1 R00602Z42921 F06132 415995 1564.1 NM.004573 M95678 BE242666 AW504110 AW408049 AW402206 AA774879 AW630959 AI439623 AI933994 AW751282 AW374413 AA578823

H18054 AA310466 F12578T74300 AA353176 AW950138 AW950600 AA912021 A1524064 AW183098 AI416986 AW769231 A1767111 AA293723

AI422290 AA465038 A

418964 1809680.1 T74640 T74649 424339 23827.1 BE257148 BE312111 AF219137 NM.015720 BE313658 BE382652 BE252205 BE251553 F12128T66208 BE255806 BE254484 AA324163 H07952

AL134164 AI867802 AI204971 AI282924 AW192547 AI652760 AI266471 AI083778

427010 27436.1 AW138332 AW207450 AW138931 AW136963 NM.012219 AF043938 AA931386 AI084600 AA975999 BE551105 AA450260 AI080368 AA324154

AF022080 BE009901 AL118847W44458 AI765270AA453121 AI148638 AI373696 AA324153 BE174809 AA350765

427239 27647.1 BE270447 AW409921 BE207288 BE207170 D56355 BE263223 BE408171 BE262243 BE392439 BE292738 BE261776 BE314300 BE267719

BE268715 BE513876 BE295291 BE297066 AA210923 BE407519 H51344 BE622905 AW248281 AW250313 T19021 AA355115 AA316879

BE269633 BE621936 AA290724

427326 277229.1 AI287878 AI804160 AA400787 428542 29266.1 D79989 NM.014770 U81031 AA352392 AA984512 H38328 AL120358 AL134787 AL134589 AI637763 AI671506 AA526909 AI651627 AW243560

AA939069

428948 29737.1 BE514362 AI879343 BE272870 BE616390 AW163444 AW161588 AW378754 AW238803 BE267205 BE047746 BE207213 BE3-12782 BE266301

BE266413 BE278348 BE280885 BE278833 BE281417 BE407786 BE378176 BE392818 AW377597 BE395951 BE393978 AW327483 BE394175

BE385795 BE275663 BE3

432118 341702 -1 N98718 432499 34857.1 BE276633 NM 016577 AF166492 BE276152 AF091031 AA908607 U66623 AI570393 AA682567 AW593957 AI148105 AW002431 AI637463

AI767195AA339439 R13005 R23431 AW961068 AA233819 AA224118 R19618 AI890314 Z46184

433075 35820.1 NM.002959 X98248 AA233278 AA846376 AI470560 AI470533 BE327147 AW291971 AA017125 AI198417 AI365213 AI168442 AI337018

AI475049 H85459 AA969895 AA888000 AA418326 AA418378 N71981 AL043634 AA426361 AA418275 AA232975 AL036861 BE277220 BE387505

N99710 AW375004A

433494 3679.1 AB029396T04934 R21715 R19005 H11563 H14256 R46605 Z40857 BE218899 AI457785 BE550988 AI693847 AA961017 H40944 M78617

H38447 N80090 BE549719 BE550952 AW005546 AI332686 AI928848 N49234 R44075 AI694943 AI858538 AI290722 BE550759 R43116 H40212

H40089 AA018091

434755 3927641 AA648502 AA814365 AW976711 AA746117 436735 425.1 L48489 AL022312 D13789 AI761974 AW173260 AW271715 AA837437 AI075278 AI367012 AI953032 AI571173 H44868 AA743691 H47026

AA837368 AA829826 AA713585 AW502618 AW500856 AW501353 AW499765 AA339125 H19141 H29645 R18883 AW450375 AA326081

AW406015 BE263659 N52684 A

440242 4895361 AW295871 AI005144 AA909877 T52634 AI239684 AA875959 BE171353 AI767633 AW510907 AI742007 449405 806511 AA001350 AA203114 H83070 R00660 450739 8449171 AI732707AI742120 451320 865761 AW118072 AI631982 T15734 AA224195 AI701458 W20198 F26326 AA890570 N90552 AW071907 AI671352 AI375892 T03517 R88265 AI124088

AA224388 AI084316 AI354686 T33652 AI140719 AI720211 T03490 AI372637 T15415 AW205836 AA630384T03515 T33230 AA017131 AA443303

T33623

459298 983107 J R86701 R84600 AL157655.,

TABLE 22C:

Pkey: Unique number corresponding to an Eos probeset

Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (Gl) numbers. "Dunham I. et al." refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al. (1999) Nature 402:489495

Strand: Indicates DNA strand from which exons were predicted NLposition: Indicates nucleotide positions of predicted exons

Pkey Ref Strand NLposition

400471 9931670 Minus 105629-105760

400518 9796703 Plus 37240-37774

400551 9801071 Minus 40629-40934

400563 9844011 Plus 81941-82434

400565 9863505 Minus 93178-93429

400726 8118950 Plus 51524-51786

400748 8119063 Plus 84237-84398

400772 8131629 Minus 34896-35021,41078-41197

400833 8705148 Minus 187599-188138

400836 8954179 Plus 677-1188

400843 9188605 Plus 5863-5970,7653-7784,8892-9023,9673-9807,10634-10789,15254-15403,23827-23958

400845 9188605 Plus 34428-34612

400846 9188605 Plus 39310-39474

400894 9958307 Minus 84607-85554

400933 7651935 Minus 105330-105503

400985 8085497 Minus 5856-6006,6236-6402

401118 9966714 Minus 111939-112126

401134 7210005 Plus 51210-51406

401180 9438648 Minus 150981-152128

401215 9858408 Plus 103739-103919

401281 9800073 Minus 13622-15130

401454 9186923 Minus 114659-114832

401488 7341775 Plus 54523-54686,55364-55451,55737-55846,58047-58175,58261-58356

401507 7534110 Plus 71055-71259

401510 7622346 Minus 46835-47126

401542 8072607 Minus 87695-87840

401577 9280797 Minus 139377-139674,141195-141281,142217-142340

401736 3219338 Plus 1771-1894

401885 8140731 Plus 148234-148321,150365-150559

401935 3808091 Plus 46329-46473

401960 3249127 Minus 87589-88081

402053 8083229 Plus 62703-63179

402115 8547592 Minus 101750-102018

402171 8575908 Minus 79357-79514,83258-83476

402183 7658390 Minus 100618-104298

402191 8576073 Minus 69410-69583

402207 8576119 Plus 41683-41851

402209 8576119 Minus 53315-53472

402211 7689783 Minus 67414-68229

402338 6957691 Minus 36915-37250

402393 9929688 Plus 19813-20084,20163-20263

402453 7534025 Plus 41-631

402460 9796884 Minus 108901-109254,110246-110581,113613-113960

402463 9796896 Minus 8818-8952

402478 9797301 Minus 106204-106535

402497 9797775 Plus 98984-99452

402632 9931268 Plus 101166-101419

402651 7960391 Plus 174215-174380

402665 8077033 Minus 11824-12090,14290-14544

402758 9213869 Plus 87638-87924 402760 9213869 Plus 136829-136952,137336-137521

402823 8217451 Plus 57916-58170,58475-58759,59580-59867

402912 7263904 Plus 145965-146257,150876-151368

402915 7406502 Minus 140-276

402916 7406502 Minus 361-474,541-687

403213 7630897 Minus 162572-162739,164442-164540

403248 7656833 Minus 167439-167606

403268 7230852 Minus 73832-73962

403379 9438244 Minus 117348-117560

403655 8736093 Plus 65668-65859

403672 7283286 Minus 96600-96881,96951-97280,97393-97594

403692 7387384 Minus 93803-93938

403771 7770492 Plus 112901-113045

403949 7711972 Minus 1731-1941

404199 6010176 Minus 1669-2740

404527 8152087 Plus 127737-127796,128080-128210,129888-130054,132545-132869

404528 8152087 Plus 135325-135486

404596 9958262 Minus 104807-105043

404676 9797204 Minus 56167-56342,58066-58189,58891-59048,60452-60628

404679 9797204 Plus 125964-126092,126691-127011,127774-127893

404716 9838068 Minus 123145-123417

404757 7706327 Plus 100933-101083,101580-101782

404879 5103013 Plus 78346-78473,78693-78893

404946 7382189 Plus 134445-134750

404953 7387324 Plus 16588-17031

404968 6899755 Plus 39287-39606

405020 7137674 Plus 106606-107309

405137 8570507 Plus 158969-159423

405187 7229826 Plus 117025-117170,118567-118736

405202 7230116 Plus 40209-40429

405282 3810573 Minus 10482-10689

405370 2078469 Minus 38980-39111

405371 2078469 Minus 47657-47766,48461-48596

405473 8439781 Plus 153074-153343,154501-154598,156879-156999,158863-159051,159910-160053,161109-161229,163035-163131,165163- 165259,165868-166003,167375-167552,169252-169364,171127-171281

405474 8439781 Plus 172005-172175

405546 1054740 Plus 124010-124183

405574 3820491 Minus 33200-33646

405594 6960456 Plus 161628-161734,162823-163014,164439-164652

405683 4508157 Minus 21701-21844

405697 4309923 Minus 56765-57010,57696-58016

405714 4156179 Minus 42789-43553

406128 9159110 Plus 50425-50876

406370 9256130 Plus 125320-125482

406432 9256504 Plus 3804-3930,4026-4120,4929-5109

406441 9280715 Plus 26200-26458

406458 9756020 Plus 145874-146911

406495 7711328 Minus 174661-174978

406496 ^' 7711328 Minus 178947-179264,181779-182087

406530 7711474 Minus 11703-11860,14711-14829,14920-14984,16232-16448,16916-17087

406538 7711478 Plus 35196-35367,38229-38476,4008040216,43522-43840

406591 8224230 Minus 2117-2257,2436-2540

406617 8439858 Plus 36430-36552

Table 23A lists about 779 genes up-regulated in ovarian cancer compared to non-malignant adult ovaries. These were selxted as for Table 20A, except that the ratio of "average" ovarian cancer to "average" normal ovaries was greater than or equal to 4.0, the "average" ovarian cancer level was set to the 93rd percentile value amongst various ovarian cancer spximens, the "average" normal adult tissue level was set to the 93rd percentile value amongst various non-malignant adult ovaries, the "average" ovarian cancer value was greater than or equal to 200 units.

TABLE 23A:

Pkey: Unique Eos probeset identifier number

Ex. Accn: Exemplar Accession number, Genbank xcession number

UG ID: UniGene number

Title: UniGene gene title

Protein Dom.: Predicted protein domain

RI: Ratio of tumor to normal ovaries

Pkey Ex. Accn UG ID Title Protein Dom. R1

421296 NM 002666 Hs.103253 perilipin perilipin.SS 37.8

437897 AA770561 Hs.146170 hypothetical protein FLJ22969 SS,TM,zf-DHHC 29.2

453028 AB006532 Hs.31442 RxQ protein-like 4 DEAD,helicase_C,Fork_head 27.6

441021 AW578716 Hs.7644 H1 histone family, member 2 27.2

422310 AA316622 Hs.98370 cytochrome P450, subfamily IIS SS,TM,pkinase,fn3,ig 26.5

454017 AW023617 Hs.347130 hypothetical protein FU22709 SSJM.myosin head.RA.DAG 25.9

438424 AI912498 Hs.25895 hypothetical protein FLJ14996 SSJM 25.8

435017 AA336522 Hs.12854 angiotensin II, type I rxepto 25.0

409518 BE384836 Hs.3454 KIAA1821 protein SS 23.3

410418 D31382 Hs.63325 transmembrane protease, serine SSJMJdl r ept a,trypsi 22.8

439924 AI985897 Hs.125293 ESTs SS 22.7

446374 AA329256 Hs.24756 ESTs, Moderately similarto al 22.6

431773 BE409442 Hs.268557 plxksfrin homology-like domai PH,SS,LIM,Troponin 21.4

420839 AI792682 Hs.282960 hypothetical protein MGC10870 SS,DS,UPF0139,Glyco hydro 21.4

413436 AF238083 Hs.68061 .sphingosine kinase 1 DAGKc 21.2 424420 BE614743 Hs.146688 prostaglandin E synthase MAPEG,SS,TM,MAPEG 20.7

422645 L40027 Hs.118890 glycogen synthase kinase 3 alp pkinase.SS.Ets 20.7

436725 BE045223 Hs.136912 hypothetical protein MGC10796 20.4

422098 H03117 Hs.111497 similar to mouse neuronal prot TM 20.2

429556 AW139399 Hs.98988 ESTs SS,pkinase,PMP22_Claudin 20.1

434068 AA977935 Hs.127274 ESTs SS 20.0

423767 H18283 Hs.132753 F-box only protein 2 F-box,SS,F-box,HORMA 19.9

423652 AF052122 Hs.130712 Homo sapiens clone 23929 mRNA ABC1,SS,PID,PID 19.8

422179 AF091619 Hs.112667 dynein, axonemal, intermediate WD40.SS 19.3

441356 BE384361 Hs.182885 ESTs, Weakly similar to JC5024 SS,TM,ank 18.5

418969 W33191 Hs.28907 hypothetical protein FU20258 SH3.SH3 17.2

432631 H08379 Hs.165563 hypothetical protein DKFZp434N TM,DπaJ,UBA,ArfGap,hom∞b 17.2

439108 AW163034 Hs.6467 synaptogyrin 3 Synaptogyrin,SS,TM,PDZ,WD 17.2

451643 M64437 Hs.234799 breakpoint cluster region RhoGEF,RhoGAP,PH,C2 17.2

434518 H56995 Hs.37372 Homo sapiens DNA binding pepti SS 16.9

413244 AW955951 Hs.159265 kruppel-related zinc finger pr SS,TM,BTB,Pep_M12B_propep 16.3

456642 AW451623 Hs.109752 putative c-Myc-responsive 16.2

421612 AF161254 Hs.106196 8D6 antigen Idl rxept a.SSJM 16.0

456177 NM 012391 Hs.79414 prostate epithelium-spxific E Ets,SAM_PNT 15.7

409261 BE315042 Hs.19210 hypothetical protein MGC11308 15.6

414837 U24266 Hs.77448 aldehyde dehydrogenase 4 famil aldedh 15.6

401278 Target Exon Band 41 15.4

444804 AI084452 Hs.22158 hypothetical protein FU21988 SS 15.4

406620 M81105 Hs.146550 myosin, heavy polypeptide 9, n myosin.head.MyosinJail.l 15.1

421495 AI583067 Hs.149152 ESTs, Weakly.similar to RHOP M 15.0

416893 AA455588 Hs.62406 hypothetical protein FU22573 SS,rrm,SS 15.0

442620 C00138 Hs.8535 Homo sapiens mRNA for KIAA1668 SS,RNA_pol_K 14.9

406901 M14624 gb:Humaπ 4-beta-galxtosylfran 14.6

416006 AA324251 Hs.78950 branched chain keto xid dehyd El.dehydrog 14.6

455557 AW995839 gb:QV4-BN0044-110200-108-h07 B Metallophos 14.4

416819 U77735 Hs.80205 pim-2 oncogene pkinase,SS,TM,OTU,K_tetra 14.3

444441 AW613841 Hs.301394 hypothetical protein MGC3101 14.0

406918 M88357 gb:Homo sapiens DNA-binding pr zf-C2H2,SS 14.0

407605 W03512 Hs.6479 hypothetical protein MGC13272 SS,Sema,pkinase,TIG,PSI,e 13.6

447304 Z98883 Hs.18079 phosphatidylinositol glycan, c SS,Peptidase C2 13.6

402365 Target Exon SS,SS,TM,ig 13.4

407767 W15398 Hs.38628 hypothetical protein SS,zf-CCCH 13.3

432931 AF174487 Hs.293753 Bcl-2-related ovarian killer p 12.7

439233 AA831893 Hs.292767 hypothetical protein FU23109 zf-C3HC4,TM,Sulfate trans 12.7

423801 NM 015071 Hs.132942 GTPase regulator associated wi RhoGAP,SH3,PH 12.6

430397 AI924533 Hs.105607 bicarbonate transporter relate HC03_cotransp,SS,TM 12.6

411570 BE144584 Hs.314341 ESTs 12.5

400206 Eos Control SS.SS.GIyco tranf 43.COLF 12.3

457941 AI004525 Hs.14587 ESTs, Weakly similar to AF1518 SS,TM,SS,TM 12.2

412674 X04106 Hs.74451 calpain 4, small subunit (30K) efhaπd.SS.CAP GLY 12.0

400460 C11002253*:gi|129091|sp]P23267 SS,TM,SCAN,zf-C2H2,KRAB 12.0

417595 AA424317 Hs.6259 KIAA1698 protein SSJM.GIyco hydro 31,Glyc 11.6

428758 AA433988 Hs.98502 CA125 antigen; ucin 16 SS 11.5

424707 BE061914 Hs.10844 Homo sapiens cDNA FLJ14476 fis SS,SS,TM,Sema 11.5

444359 A1697160 Hs.143594 ESTs, Weakly similar to HS4LJH 11.5

435158 AW663317 Hs.65588 DAZ associated protein 1 rrm.SS.rrm 11.3

407688 W25317 Hs.37616 Human D9 splice variant B mRNA 11.3

450503 R35917 Hs.301338 hypothetical protein FLJ 12587 SS 11.2

427448 BE246449 Hs.2157 Wiskott-Aldrich syndrome (xze WH1,PBD,WH2,SS 11.2

406230 Target Exon 11.2

432143 AL040183 Hs.123484 Homo sapiens, clone IMAGE:4178 SSJM.cys rich.FGFR 11.2

433573 AF234887 Hs.57652 cadherin, EGF LAG seven-pass G SS,TM,7tm_2,EGF,cadherin, 11.1

413726 AJ278465 Hs.75510 annexin AH anπexin.SS.annexin 11.1

431974 AW972689 Hs.200934 ESTs bZIP 11.0

428167 AA770021 Hs.16332 ESTs SS,ig,fn3 11.0

450461 BE408081 Hs.46736 hypothetical protein FU23476 SS 10.9

412738 N34731 Hs.74562 siah binding protein 1; FBP in homMbox 10.9

445434 BE391690 Hs.9265 hypothetical protein FU20917 SS,PWWP,Exonuclease,lipoc 10.9

444008 BE544855 Hs.236572 ESTs, Weakly similar to SFR4.H SS,SS,SAC3 GANP 10.7

444410 BE387360 Hs.33719 ESTs, Moderately similar to S6 SS 10.6

444607 AW405635 Hs.293687 ESTs SS,PI-PLC-X,PH,PI-PLC-Y,C 10.6

404333 C7001735*:gi|7768636|dbj|BAA95 vwd 10.5

401210 C12000519:gi|7710046|ref|NP_05 10.5

434743 AI363410 ribosomal protein S18 SSJM 10.4

434030 AW162336 Hs.3709 low molxular mass ubiquinoπe- SS 10.4

450029 AW073380 Hs.267963 hypothetical protein FU 10535 SS,Pyridox_oxidase,zf-C2H 10.4

439632 AW410714 Hs.334437 hypothetical protein MGC4248 SS,TM,fransmembraπe4 10.3

438185 Y19188 Hs.320461 ESTs SS 10.2

432031 AF039196 Hs.272367 hairless protein (putative sin jmjC 10.2

405371 NM_005569*:Homo sapiens UM do pkinase.UM.PDZ 10.1

456741 W37608 Hs.184492 ESTs SS.pkinase 10.1

458130 AA115811 Hs.6838 ras homolog gene family, membe ras.arf 10.0

456977 AK000252 Hs.169758 hypothetical protein FU20245 10.0

420029 BE258876 Hs.94446 polyamiπe-modulated fxtor 1 aldo keLred.SS.TM.gla 10.0

445625 BE246743 hypothetical protein FU22635 SSJM 9.9

423366 Z80345 Hs.127610 xyl-Coenzyme A dehydrogenase, Acyl-CoA_dh.Acyl-CoA.dh_M 9.8

458216 AW024282 Hs.104938 hypothetical protein MGC15906 9.8

451721 NM.006946 Hs.26915 spxtrin, beta, non-erythrocyt spxtrin.PH.CH.SS.Peptida 9.7

421445 AA913059 Hs.104433 .Homo sapiens, clone IMAGE:4054 asp,SS,TM,ion_frans,K_tet 9.7 431354 BE046956 Hs.251673 DNA (cytosiπe-5-)-methyltransf SS.PWWP.PHD 9.7

443780 NM.012068 Hs.9754 xtivating transcription fxto bZIP,NTP_transf_2,SS,TBC 9.7

448133 AA723157 Hs.73769 folate rxeptor 1 (adult) Folate rx.SS 9.7

444202 AL031685 Hs.12785 KIAA0939 protein SS,TM,Na H_Exchanger,ABC2 9.7

427640 AF058293 Hs.180015 D-dopxhrome tautomerase MIF.Iate protein L2,SS,GS 9.6

419167 AI589535 Hs.94875 ESTs, Weakly similar to A35363 SS 9.6

424618 L29472 Hs.1802 major histocompatibility compl TM,ig,MHC_ll_beta,SS,TM,A 9.6

427497 AW139476 Hs.31240 ESTs 9.6

420423 AA827718 Hs.88218 ESTs SS 9.6

414756 AW451101 Hs.159489 ESTs, Moderately similar to JC hexokinase2,hexokinase 9.6

407893 BE408359 Hs.43621 Homo sapiens, Similar to hypot SS,SS,arf,ras,fn3,ras 9.5

408294 BE141732 gb:QV0-HT0101-061099-032-e07 H Ammoniumjransp 9.5

442232 AI357813 Hs.337460 ESTs, Weakly similar to A47582 SS,TM,TGFb_propeptide,TGF 9.4

416866 AA297356 Hs.80324 serine/threonine protein phosp Metallophos.Metailophos 9.4

419823 AW271708 Hs.118918 ESTs, Weakly similar to M20M.H SSJM 9.4

422625 AW504698 Hs.155976 culliπ 4B SS,SS,Cullin,CuIlin 9.3

401264 C18000090*:gi|6678656|ref|NP_0 SSJaminin Ntermjaminin 9.3

407507 U73799 gb:Human dynxtin mRNA, partia SSJM.HC03 cotransp.CAP.G 9.2

400833 C11000890:gi|3746443|gb|AAC639 SS,TM,7tm_1 9.2

422064 AW452589 Hs.335742 ESTs TM 9.2

452434 D30934 Hs.29549 C-type Ixϋn-like rxeptor-1 Ixtin c.SS.TM 9.2

421363 NM 001381 Hs.103854 dxkiπg protein 1, 62kD (downs PH,IRS,TM,PH,IRS,trypsin, 9.1

427397 AI929685 Hs.177656 calmodulin 1 (phosphorylase ki efhand,RrnaAD,SS,efhand 9.1

431462 AW583672 Hs.256311 granin-like neuraendxrine pep SS 9.0

434796 AA812046 ESTs SS,myb_DNA-binding,myb_DN 9.0

422639 AI929377 Hs.173724 creatine kinase, brain ATP-gua Ptraπs,ATP-gua_Pt 9.0

447867 AI525268 Hs.164303 ESTs TM 9.0

442472 AW806859 gb:MRO-ST0020-081199-004-c03 S SS,TM,lπos-1-P_synth,Occl 8.9

455588 AI129903 Hs.74669 vesicle-ass∞iated membrane pr synaptobreviπ.SSJM 8.9

454319 AW247736 Hs.101617 ESTs, Weakly similar to T32527 SS 8.9

429527 AA454184 Hs.289014 ESTs 8.9

432603 AA554920 Hs.105794 UDP-glucose:gIycoprotein gluco SSJM 8.9

410338 W03445 Hs.38205 gb:za05g11.r1 Soares melaπocyt pkinase 8.9

452833 BE559681 Hs.30736 KIAA0124 protein WD40 8.9

407363 AF035032 Hs.181125 gb:Homo sapiens clone MCA1L my SS,ig,SS,G_glu transpept 8.8

414413 BE294877 gb:601174162F1 NIH_MGC_17 Homo SS 8.8

431765 AF124249 Hs.268541 novel SH2-contaiπing protein 1 SH2.SSJM 8.8

421694 BE387430 Hs.106880 bystin-like 8.8

453683 AL079854 Hs.118598 Homo sapiens mRNA for KIAA1878 SS 8.8

418736 T18979 Hs.87908 Snf2-related CBP xtivator pro SS,helicase_C,AT_hook,SS, 8.7

450958 AL137669 Hs.348012 Homo sapiens mRNA; cDNA DKFZp4 8.7

419725 U66048 Hs.92683 Homo sapiens clone 161455 brea 8.7

415126 D60945 gb:HUM141D04B Clontxh human f SSJM 8.7

406301 Target Exon TM 8.6

418843 AJ251016 Hs.89230 potassium intermediate/small c TM,CaMBD,SK chanπel.TM 8.6

433396 AI742071 Hs.133205 ESTs SSJM 8.6

434333 AA186733 Hs.292154 stromal cell protein 8.6

407065 Y10141 gb:H.sapiens DAT1 gene, partia SNF.SSJM 8.6

452851 AW173191 Hs.213117 ESTs SS.Sema 8.6

422418 AK001383 Hs.116385 hypothetical protein FLJ 10521 RhoGEF 8.6

447859 AK002194 Hs.19851 peroxisomal biogenesis fxtor 8.6

420836 AW958453 Hs.204959 hypothetical protein FU 14886 SS.ras 8.6

429099 BE439952 Hs.196177 phosphorylase kinase, gamma 2 pkinase,SS,SNF2_N,helicas 8.6

419639 AK001502 Hs.91753 hypothetical protein 8.6

429712 AW245825 Hs.211914 ENSP00000233627*:NADH-ubiquino oxidored q6,SS,TM,rrm 8.5

452554 AW452434 Hs.58006 ESTs, Weakly similar to ALU5.H SS,PAS,HLH 8.5

441076 N49809 Hs.11197 Homo sapiens, clone IMAGE:3343 8.5

428860 U38291 Hs.194301 microtubule-ass∞iated protein M 8.5

421901 AB014554 Hs.109299 protein tyrosine phosphatase, SAM,SS,TM,rrm,PDZ 8.4

441363 AW450211 Hs.126825 ESTs, Weakly similar to A46302 SS,TM,HSP20,7tm 1 8.4

443801 AW206942 Hs.253594 intran of: trichorhinophalang GATA 8.4

432862 AW004958 Hs.236720 amnionless protein SS,MATH,zf-TRAF,zf-C3HC4 8.4

431849 AI670823 Hs.85573 hypothetical protein MGC10911 SSJM 8.4

423662 AK001035 Hs.130881 B-cell CLUIymphoma 11 A (zinc SS 8.3

404365 Target Exon SS 8.3

425694 U51333 Hs.159237 hexokiπase 3 (white cell) hexokinase,hexokinase2,he 8.3

423098 AA321980 Hs.204682 ESTs 8.3

434552 AA639618 Hs.325116 Homo sapiens, clone MGC:2962, SS 8.2

418361 AW505368 Hs.12460 gb:UI-HF-BN0-alu-d-03-0-Ul.r1 8.2

427433 D82070 Hs.177972 chromosome 4 open reading fram SS.pkinase 8.2

420138 BE268854 Hs.177729 ESTs SS 8.2

426391 AW161050 Hs.169611 second mitochondria-derived x SS 8.1

457613 AA598869 Hs.173770 ESTs 8.1

427502 AI811865 Hs.7133 Homo sapiens, clone IMAGE:3161 SSJM.ABC tran.Glyco Iran 8.1

437215 AL117488 Human clone 23564 mRNA sequenc SS 8.1

423384 AL133632 Hs.127808 Homo sapiens mRNA; cDNA DKFZp4 8.1

447151 AI022813 Hs.92679 Homo sapiens clone CDABP0014 m SS,TM,LRR,aminotran_1_2 8.0

431898 AK000020 Hs.272018 hypothetical protein FU20013 8.0

454291 AW384847 Hs.213534 ESTs, Weakly similarto MUC2_H SS.XRCC1 N,BRCT,lxtamase 8.0

430354 AA954810 Hs.239784 human homolog of Drosophila Sc SS,TM,ig 8.0

459302 NM 00231-1 Hs.36566 LIM domain kinase 1 8.0

422765 AW409701 Hs.1578 bxuloviral IAP repeat-contain BIR,TK,SS,TM 8.0

425944 AK000664 Hs.164256 hypothetical protein FU20657 7.9

450873 BE464016 Hs.238956 ESTs SS,zf-C2H2,rrm 7.9 454246 AW245185 Hs 6996 ESTs 79

450635 AW403954 Hs 25237 mesenchymal stem cell protein 4HBT 79

422305 AI928242 Hs 293438 ESTs, Highly similar to AF1984 SS 79

425760 D17629 Hs 159479 galxtosam e (N-xetyl)-6-sul Sulfatase,SS,TM 79

413534 BE146961 gb QV4-HT0222-011199 0194)12 H SSJM 78

446931 AI348856 Hs 21627 gb tb05a05 x2 NCI_CGAP_Lu26 Ho 78

421726 AK001237 Hs 319088 hypothetical protein FU 10375 TM 78

427461 AA531527 Hs 332040 hypothetical protein MGC13010 SS,TM,ACAT,LRR 78

448993 AI471630 KIAA0144 gene product 78

443136 NM 001440 Hs 9018 exostoses (multιple)-lιke 3 Exostosin.SSJM 78

427725 U66839 Hs 180533 mitogen xtivated protein kma pkinase 78

400923 Target Exon SSJM.DUF289 78

419757 AA773820 Hs 63970 ESTs SSJM 78

458834 AI566883 Hs 196446 ESTs 78

427899 AA829286 Hs 332053 serum amyloid A1 SS,SAA_proteιns,SS,SAA_pr 77

452399 BE513301 Hs 29344 hypothetical protein, clone 24 SS.peπlipin 77

436543 NM.002212 Hs 5215 integnn beta 4 binding protei elF6 77

431811 AB040972 Hs 301696 hypothetical protein FU11560 SS,TM,Band_7,AAA,cdc48_N, 77

414534 BE257293 Hs 76366 BCL2-antagonιst of cell death SS,hormone_rx,zf-C4 77

455885 BE153524 gb PM0-HT0339-241199-002-C03 H SS.pkinase 77

427721 AI582843 Hs 180455 RAD23 (S cerevisix) homolog ubiquitm.UBA.integπn B, 76

430432 AB037758 Hs 241419 KIAA1337 protein TM,Patched,TM 76

427273 AW139032 Hs 107376 hypothetical protein DKFZp434N SS.SSJM 76

450334 AF035959 Hs 24879 phosphatidic xid phosphatase PAP2.SS 76

413564 BE260120 gb 60114699QF1 NIH.MGC 9 Homo 76

410397 AF217517 Hs 63042 DKFZp564J 157 protein SS,homeobox,UPF0160,DUF23 76

439539 BE348395 Hs 121589 ESTs SS,Fork_head 75

400286 C16000922 gι|7499103|pιr||T209 TM.ABC tran.ABC membrane 75

416472 AA180756 Hs 340316 ESTs, Moderately similarto AL zf-C2H2 75

418641 BE243136 Hs 86947 a disiπtegπn and metalloprote dιsιntegπn,Reprolysιn,Pe 75

419492 AA243547 Hs 19447 PDZ-LIM protein mystique LIM,SS,SH3,Sorb,Metalloph 75

420970 AA305079 Hs 1342 cytochrome c oxidase subunit V COX5B 75

406495 Target Exon SRCRJM.Acetyltransf 75

448043 AI458653 Hs 201881 ESTs PHD 74

401724 C16001374 gι|6755086|ref|NP_03 TM,PLAT,SS 74

424263 M77640 Hs 1757 L1 cell adhesion molecule (hyd frι3,ιg,IRK,SS,TM,fn3,ιg,R 74

428092 AW879141 ESTs SSJM 73

453023 AW028733 Hs 31439 senne protease inhibitor, Kun Kunιfz_BPTI,SS ,TM lon.tra 73

400137 Eos Control 73

436127 W94824 Hs 11565 RIKEN cDNA 2010100012 gene Corona 7.SS.TM 73

412265 AA101325 Hs 86154 hypothetical protein FLJ12457 UPP synthetase,HMG14 17 73

432747 NM 014404 Hs 278907 calcium channel, voltage-depen PMP22 Claudm,SS,TM,PMP22 73

448859 BE272446 Hs 265317 hypothetical protein MGC2562 SSJPR 73

407619 AL050341 Hs 37165 collagen, type IX, alpha 2 SS,Collagen,SS,Collagen 73

429299 AI620463 Hs 347408 hypothetical protein MGC13102 SS,TM,gla 73

401674 C16001417* gι|7500345|pιr||T21 FAD-oxidase C.FAD binding 72

412289 AW935967 Hs 170162 KIAA1357 protein SS 72

424198 AB029010 Hs 143026 KIAA1087 protein SS,TM,Na_Ca_Ex,Calx-beta, 72

412173 T71071 gb yc50b05 ri Stratagene liver CPSase_L_chaιn 72

438113 AI467908 Hs 8882 ESTs SS,TM,7tm_1 72

429869 AI807018 Hs 15977 Target CAT rrm 72

439963 AW247529 Hs 6793 platelet-activating fxtor xe PAF-AH lb,Lιpase GDSL.SS, 72

425041 AI377150 Hs 150914 ESTs SS 72

448340 AI492910 Hs 32362 ESTs 7 1

406779 AA412048 Hs 279574 CGI-39 protein, cell death reg SS.SS 71

431005 AA490544 Hs 127269 ESTs, Weakly similar to T02345 WD40 7 1

421273 AJ245416 Hs 103106 U6 snRNA-associated Sm-like pr Sm,SS,tRNA-synt_1,GST„C,G 71

409649 AA159216 Hs 55505 hypothetical protein FU20442 Y_phosphatase,DSPc,TM 70

430281 AI878842 Hs 237924 CGI-69 protein mιto_carr,SS,TM 70

444672 Z95636 Hs 11669 laminin, alpha 5 lamιnιn_EGF,lamιnιn_G,EGF 70

405928 Target Exon SS,cystatιn,Coprogen_oxιd 70

421321 NM_005309 Hs 103502 glutamic pyruvate transamiπase amiπotran 1_2,SS,TM,LRR 69

439905 AW799755 Hs 110953 retmoic xid induced 1 HLH 69

451937 AF119664 Hs 27299 transcπptional regulator prot SS,ιntegπn_B,fn3,Calx-be 69

426675 AW084791 Hs 133122 hypothetical protein FU14524 SS,TM,amιnotraπ_1_2 69

438627 AI087335 Hs 123473 ESTs TM.Reticulon 69

438951 U51336 Hs 6453 inositol 1,3,4-tπphosphate 5/ SS,oxιdored_nιtro,SS 68

421758 BE397336 Hs 1422 Gardner-Rasheed feline sarcoma SH2,SH3,pkιnase 68

423228 AL137491 Hs 125511 Homo sapiens mRNA, cDNA DKFZp4 SSJM.sushi 68

405346 Rag C protein RCC1 68

432746 AA564512 Hs 24301 polymerase (RNA) II (DNA dirx SSJM.EF1BD 68

452798 AI918771 Hs 257170 ESTs SS,TM,TNFR_c6 67

426315 AA854219 Hs 348137 Homo sapiens, clone IMAGE 3542 SS.crystall 67

440317 BE561888 gb 601346093F1 NIH_MGC_8 Homo 67

438857 AI627912 Hs 130783 Forssman synthetase SS,RA,RasGEF,RasGEFN 67

452072 BE258857 Hs 27744 RAB3A, member RAS oncogene fam ras,arf,SS,PDEase 67

433938 AF161536 Hs 284292 ubiquiπol-cytochrome c reducta TM 67

423106 N52572 Hs 13702 ESTs, Moderately similar to AL 67

453101 AW952776 Hs 94943 ESTs TM 67

420307 AW502869 Hs 66219 ESTs SSJM 67

415056 AB004662 Hs 77867 adenosme Al rxeptor 7tm_1,SS,TM 67

454262 AW612232 Hs 254835 ESTs SS,TM,voltage_CLC,CBS 67

409227 AA806165 Hs 130323 Homo sapiens, clone IMAGE 3960 66

413908 BE409966 Hs 323813 Homo sapiens, clone MGC 2867, SS,zf-C2H2 66 457274 AW674193 Hs 227152 maπnan binding Ixtin seπne p SS,TM,SS,TM,ClathπnJg_c 66

419157 AA234540 Hs 23871 ESTs pkinase 66

431424 AI222969 ESTs SS 66

412464 T78141 Hs 22826 ESTs, Weakly similar to 155214 SS.cadheπn.crystall 66

430168 AW968343 DKFZP434I1735 protein SS,TM,efhand,efhand 66

455035 AW851734 gb MR2-CT0222-011199-007-e10 C 66

422682 W05238 Hs 94316 ESTs, Weakly similar to T31613 SS,TM,DEAD,heIιcase C.Lam 66

453367 AW732847 Hs 70573 PKCI-1-related HIT protein SSJM 66

450593 AF129085 Hs 25197 STIP1 homology and U Boxconta TPR,SS,TM,Rhomboιd,lactam 66

420319 AW406289 Hs 96593 hypothetical protein ras.arf 66

431131 N84730 Hs 250616 is∞itrate dehydrogenase 3 (NA isodh.isodh 66

431297 AA651771 Hs 3076 ESTs 66

410082 AA081594 Hs 158311 Musashi (Drosophila) homolog 1 SS,HECT,phoslιp 65

441307 AW071696 Hs 209065 hypothetical protein FLJ14225 SSJM 65

454682 AW816029 gb MR3-ST0220-151299 027-b10 S filament 65

407299 AA460205 Hs 289770 ESTs, Weakly similar to I38022 65

422837 U25441 Hs 121478 dopamine rxeptor D3 7tm_1,SS,TM,7tm_1 65

407722 BE252241 Hs 38041 pyπdoxal (pyπdoxme, vitamin pfkB.SS 64

417810 D28419 Hs 82609 hydroxymethylbilane synthase Porphobil deam 64

445333 BE537641 Hs 44278 hypothetical protein FU12538 SS 64

402197 Target Exon SS.TM.ATP1G1 PLM MATβ.ig, 63

419390 AI701162 Hs 90207 hypothetical protein MGC11138 SS,TM,PMP22_Claudm,PMP22 63

447754 AW073310 Hs 163533 infroπ of HER4 63

444664 N26362 Hs 11615 map kinase phosphatase-Iike pr DSPc,Rhodanese,SS,TM 63

421190 U95031 Hs 102482 mucin 5, subtype B, frxheobro Cys knot.vwc 63

432872 AI908984 Hs 279623 selenoprotein X, 1 DUF25,SS,Rιbosomal L3.PDZ 63

430023 AA158243 Hs 227729 FK506-bιπdιng protein 2 (13kD) SS,FKBP,SS,PDGF,C2,PI-PLC 63

413343 BE392026 Hs 334346 hypothetical protein MGC13045 SS.DnaJ 62

417852 AJ250562 Hs 82749 transmembrane 4 superfamily me transmembraπe4,SS,TM 62

403128 KIAA1033 protein SS,TM,tubulιn,EGF,F5_F8 t 62

413055 AV655701 Hs 75183 cytochrome P450, subfamily HE p450 62

427812 AA770424 Hs 98162 ESTs SS 62

457761 AW401809 Hs4779 KIAA1150 protein SS,LIM,SS 62

453099 H62087 Hs 31659 thyroid hormone rxeptor-assx SS 62

426048 AI768853 Hs 134478 ESTs TM 62

407223 H96850 gb yw03b12 s1 Soares melan∞yt SS,TM,SS,TM,DDOST_48kD 62

445634 AI624849 Hs 344612 ESTs, Weakly similar to NEL1_H vwd 62

441197 BE244638 Hs 166 sterol regulatory element bind HLH 6 1

421707 NM 014921 Hs 107054 lxtomedιn-2 Lafrophιlιn,OLF,7tm 2,Gal 6 1

435750 AB029012 Hs 990 KIAA1089 protein SSJM 61

432353 NM 016558 Hs 274411 SCAN domain-containing 1 SCAN 61

427326 AI287878 gb qv23(06 x1 NCI_CGAP_Lym6 Ho SS,TM,7tm_1,SS,TM 6 1

447128 AI271898 cyclin K 61

419444 NM.002496 Hs 90443 Target CAT fer4,SS,TM,V_ATPase sub a 6 1

457978 AA776638 gb ae78g04 s1 Stratagene schiz SS,PH,IQ,RasGEF,RasGEFN,R 61

410445 AA199830 gb zq75h01 r1 Stratagene hNT n 6 1

431857 W19144 Hs 271742 ADP-πbosyltraπsferase (NAD, p PARP.PARP reg SSJM.Pepti 6 1

407143 C14076 Hs 332329 EST SSJM 60

408724 AI685842 Hs 294143 ESTs, Weakly similar to T22914 SS,pkιnase,tubulιn 60

436685 W28661 Hs 5288 Homo sapiens mRNA, cDNA DKFZp4 SS,TM,pkιnase,Actιvιn_rec 60

441583 AI791499 Hs 205742 ESTs, Weakly similar to ALUA.H 60

418802 AB028989 Hs 88500 mitogen xtivated protein kma WD40,Pιco_P2A,M,SS 60

414927 T83587 Hs 186476 ESTs SS.Sulfatase 60

434314 BE392921 Hs 3797 RAB26, member RAS oncogene fam ras.arf.SS 60

414157 BE297801 Hs 103845 ESTs, Moderately similar to 15 SS 60

424415 NMJJ01975 Hs 146580 enolase 2, (gamma, neuronal) enolase,SS,Atrophιn-1 ,Atr 60

406487 Target Exon SSJM 60

447365 BE383676 Hs 334 Rho guanine nucleotide exchang SH3,PH,RhoGEF 60

417900 BE250127 Hs 82906 CDC20 (cell division cycle 20, WD40,SS,TM,fn3,EGF,fπ3,ιg 60

442297 NM 006202 Hs 89901 phosphodiesterase 4A, cAMP-spe PDEase 59

426440 BE382756 Hs 169902 solute earner family 2 (fxil sugar tr,SS,TM,sugar fr 59

418256 AW845318 Hs 12271 f-box and leucme-πch repeat SS,SS,TM,HSF DNA-bmd 59

431543 AW969619 Hs 259768 adenylate cyclase 1 (brain) TM 59

430344 AA476827 Hs 171012 hypothetical protein FU22349 HLH 59

428539 AW410063 Hs 184877 solute camerfamily 25 (mito mιto_carr,SS,TM,profilιn, 59

403938 Target Exon Ephπn 59

456950 AF111170 Hs 306165 Homo sapiens 14q32 Jagged2 gen SSJM.DSL 59

451481 AA300228 Hs 295866 hypothetical protein DKFZp434N 59

434357 AW732284 Hs3828 mevalonate (diphospho) dxarbo GHMP.kiπases.SSJM 59

443553 AL040535 Hs 9573 ATP-binding cassette, sub-fami ABC ran.SS 59

433333 AI016521 Hs 71816 v-akt muππe thymoma viral one homxbox,pkιnase,PH,pkιna 59

430600 AW950967 Hs 274348 HLA-B ass∞iated traπscπpt-3 ubiquitin.SSJM G-patch,a 59

409034 AI684149 Hs 172035 hypothetical protein similar t SS 59

421542 AA411607 Hs 118964 ESTs, Weakly similar to KIAA11 SS.SS 59

431534 AL137531 Hs 258890 Homo sapiens mRNA, cDNA DKFZp4 SS,TM,ras 59

409608 AF231023 Hs 55173 cadheπn, EGF LAG seven-pass G SS,TM,7tm_2,cadheπn,GPS, 59

423464 NM 016240 Hs 128856 CSR1 protein Collageπ.SS 59

422379 AA932860 Hs 133864 ESTs 58

443887 NM 004729 Hs 9933 Ac-like transposable element zf-BED 58

450122 BE313765 Hs 343443 ESTs, Weakly similar to 138022 SS,TM,Y phosphatase.LON.A 58

404807 Target Exon UPF0027 58

445303 AW362198 Hs 12503 interieukin 15 rxeptor, alpha SS,sushι,SS 58

445631 AK001822 Homo sapiens cDNA FU10960 fis 58

412091 R06185 gb ye94d03 r1 Soares fetal liv SS,TM,IBR,IBR 58 446536 W74413 Hs 15251 hypothetical protein SS 58

432866 BE395875 Hs 279609 mitochondπal earner homolog mιto_caιτ 58

402393 ENSP00000085284* CDNA FU20404 RhoGEF,PH,SS,zf-CCCH,vwd 58

413041 BE061580 Hs 61622 gb MRO-BT0249-091299-201-C07 B SS 58

414356 AW505085 Hs 335147 gb UI-HF-BNO-als-a-10-O-UI r1 SSJM 58

402916 ENSP00000202587* Bicarbonate t HC03_cotraπsp,SS 57

459133 U40343 Hs 29656 cyclin-dependent kinase mhibi ank.SS.Adap comp sub 57

404757 Target Exon TM,zf C2H2 57

409879 BE083422 Hs 56851 hypothetical protein MGC2668 SSJM 57

411219 AW832917 gb QV2-TT0003-161199-013-h06 T 57

421871 AK001416 Hs 306122 glycoprotein, synaptic 2 TM,Steroιd_dh,SS 57

434067 H18913 Hs 124023 Homo sapiens cDNA FU14218 fis 57

416759 AK000978 Hs 79741 hypothetical protein FU10116 57

446562 BE272686 Hs 15356 hypothetical protein FU20254 hormone.SS.pfkB 57

407117 AA146625 gb zo71c07 s1 Stratagene pancr SS 57

444855 BE409261 Hs 12084 Tu translation elongation fxt GTP EFTU.GTP EFTU D3.GTP 57

421543 AK000519 Hs 105606 hypothetical protein FU20512 TM 57

407757 BE048414 Hs 165215 hypothetical protein MGC5395 SS.EF1G domam.GST C.GST 57

419125 AA642452 Hs 130881 B-cell CLL/lymphoma 11 A (zinc SS 57

437141 BE304917 Hs 31097 hypothetical protein FU21478 SS,TM,Glycos_transf_4 57

408905 AV655783 Hs 661 Target CAT 57

450787 AB006190 Hs 25475 aquapoπn 7 MIP.SSJM 57

432496 D45576 Hs 187959 ESTs 57

429367 AB007867 Hs 278311 plexm B1 Sema,PSI,TIG,SS,TM,TIG,Se 57

422708 AB017430 Hs 119324 kinesin-like 4 , kιnesιn,homeobox,SS,TM,zf 57

417442 AA199940 Hs 124039 ESTs 57

432751 AF152099 Hs 278911 interieukin 17C SS 57

432004 BE018302 Hs 2894 plxental growth fxtor, vascu PDGF.SS 57

454151 AA047169 Hs 154088 hypothetical protein FU22756 SSJM.GIycos transf 4 57

456145 BE299427 Hs 21446 KIAA1716 protein SS,DIX,PDZ,DEP,Dιshevelle 56

417677 NM.016055 Hs 82389 CGI-118 protein 56

451558 NMJ01089 Hs 26630 ATP-binding cassette, sub-fami ABC_tran,SRP54,SS,TM,ECH 56

408795 AW749126 Hs 170345 hypothetical protein FU13710 hormone_rx,zf-C4 56

407204 R41933 Hs 140237 ESTs, Weakly similar to ALU1.H SS.histone.histone 56

452849 AF044924 Hs 30792 hook2 protein bZIP,SS,AhpC-TSA 56

439343 AF086161 Hs 114611 hypothetical protein FLJ11808 56

459271 AL045934 gb DKFZp434M116 ri 434 (syπony SS,PI3_PI4_kιnase,PI3Ka 56

401609 C16001614 gι|7801278|emb|CAB91 56

447827 U73727 Hs 19718 protein tyrosine phosphatase, Y_phosphatase,frι3,ιg,MAM, 56

409125 R17268 Hs 343567 axonal transport of synaptic v SS,kιnesιn,PH,FHA kinesm 56

450437 X13956 Hs 24998 hypothetical protein MGC10471 SS 56

415514 F11301 Hs 138329 ESTs SSJM 56

437926 BE383605 Hs 300816 small GTP-bmding protein SSJMJPR 56

406663 U24683 immunoglobulin heavy constant SS 56

421678 AA419008 Hs 106730 chromosome 22 open reading fra SS,TM,UBA,Rhomboιd,SS,TM 56

422472 R59096 Hs 279939 mitochondnal earner homolog mito.caσ 56

414918 AI219207 Hs 72222 hypothetical protein FU13459 SSJM.efhand 56

434906 BE410573 Hs 283636 Homo sapiens, clone IMAGE 4053 SSJM.Exo eπdo_phos,BNR,A 56

414757 U46922 Hs 77252 fragile histidine tπad gene HIT 56

436014 AF281134 Hs 283741 exosome component Rrp46 RNase_PH,RNase_PH_C,SS,TG 56

421696 AF035306 Hs 106890 Homo sapiens clone 23771 mRNA 56

408015 AW136771 Hs 244349 epidermal differentiation comp 56

445871 AI702901 Hs 145582 ESTs, Weakly similar to FOR4 M SS,TM,efhand,efhand 55

411813 NM 014931 Hs 72172 KIAA1115 protein SS,TM,Y_phosphatase 55

425098 AW295349 Hs 8038 ESTs SSJM 55

429720 M79091 gb EST01239 Subtrxted Hipp∞a 55

453898 AW003512 Hs 232770 arxhidonate hpoxygenase 3 SS,TM,lιpoxygeπase,PLAT,s 55

449225 R39108 Hs 6777 ESTs SS,TM,Na_sulph_symp 55

423233 BE048021 Hs 11067 ESTs, Highly similar to T46395 55

432538 BE258332 Hs 278362 male-enhanced antigen SS,TM,AAA,Rιbosomal L2 55

408215 BE614290 syntaxin 10 SS,SS,TM,HLH,TRM,zf-CCCH 55

406244 Target Exon 55

436041 AI803516 Hs 272891 hipp∞alcm like protein 4 SS,efhand,TGF-beta,TGFb_p 55

422013 N92696 Hs 293354 ESTs SSJM 55

442451 A1498080 Hs 129616 ESTs SS 55

427859 AA416856 Hs 98170 ESTs SS,TM,DUF60,trypsιn,CUB,u 55

436540 BE397032 Hs 14468 hypothetical protein MGC14226 SSJM 55

427747 AW411425 Hs 180655 senne/threonme kinase 12 pkιnase,SS,TM,synaptobrev 54

441456 AI458911 Hs 127765 ESTs 54

431630 NM.002204 Hs 265829 integππ, alpha 3 (antigen CD4 integπn A,FG-GAP,Rhabd_g 54

415976 R43144 Hs 21919 ESTs TM 54

447374 AF263462 Hs 18376 KIAA1319 protein SS.Myosm tail.M 54

431275 T56571 Hs 10041 ESTs SS.HLH 54

404343 C7002191* gι|5053028|gb|AAD388 SS,ABC_tran 54

431461 BE299671 Hs 256310 likely ortholog of mouse ZFP28 54

421779 AI879159 Hs 108219 wingless-type MMTV integration SS,wnt,SS 54

418678 NM 001327 ' Hs 167379 caπcer/testis antigen (NY-ESO- SS,TM,zf-C2H2 54

457310 W28363 Hs 239752 nuclear receptor subfamily 2, 53

417193 AI922189 Hs 288390 hypothetical protein FU22795 SS 53

432545 X52486 Hs 3041 urxil-DNA glycosylase 2 cyclιn,SS,cyclιn 53

456573 AI279811 Homo sapiens, clone IMAGE 3953 53

409164 AA706639 gb ag90e09 r1 Stratagene hNT n SS,TM,Hιnt,HH_sιgπal,tubu 53

442296 NM.007275 Hs 8186 lung cancer candidate SS,TM,Glyco_hydro_56,Glyc 53

438670 AI275803 Hs 123428 ESTs 53 400257 ENSP00000000452 BAD protein (B SS.hormone rx,zf C4 53

449514 AW970440 Hs 23642 protein predicted by clone 236 SS,PX,arf,lιpocatιn,PHD,z 53

427336 NM 005658 Hs 2134 TNF receptor-assxiated fxtor MATH,SS,MATH,A2M N,A2M,NT 53

414551 AI815639 Hs 76394 enoyl Coenzyme A hydratase, sh ECH,Peptιdase U7.SSJM 53

447960 AW954377 Hs 26412 πng finger protein 26 SS,TM,Cbl_N,Cbl_N2,Cbl_N3 53

430605 AJ245433 Hs 247323 G4 protein SS,TM,G-patch,ubιquιtιn,a 53

456849 AA622394 Hs 153177 πbosomal protein S28 SSJM 52

430513 AJ012008 Hs 241586 G6C protein SS,TM,GST_C,abhydrolase 52

424437 BE244700 Hs 147049 cut (Drosophιla)-lιke 1 (CCAAT CUT,homeobox,beta-lxtama 52

427815 BE072019 Hs 12851 phosphatidylseπne synthase 2 SS,TM,7tm 1 52

417903 NM 002342 Hs 1116 iymphotoxm beta rxeptor (TNF TNFR_c6,SS 52

420476 AW575863 Hs 136232 ESTs SS.HLH 52

409960 BE261944 hexokmase 1 SSJM 52

436325 AL390088 Hs 7393 hypothetical protein from EURO SS.Synapsm.CSS 52

444439 AI458883 Hs 143545 hypothetical protein MGC11303 SS,TM,PAF-AH_p_ll 52

412915 AW087727 Hs 74823 NM.004541 Homo sapiens NADH de 52

418891 NM 002419 Hs 89449 mitogen-xtivated protein kma SH3,pkιπase,pyπdoxal deC 52

430323 U40714 Hs 239307 tyrosyl-tRNA synthetase DUF101,SS,tRNA-synL1b,tR 52

432396 AW295956 Hs 11900 hypothetical protein FLJ 14972 SS 52

457843 AW138211 Hs 128746 ESTs 52

429252 NM.004658 Hs 198312 RAS protein activator like 1 ( C2,PH,RasGAP,BTK,SS,C2,PH 51

429225 BE250337 Hs 198273 Target CAT WD40 51

412104 AW205197 Hs 240951 Homo sapiens, Similar to RIKEN SSJM 5 1

449750 H28586 Hs 32325 ESTs SS.ras 51

442725 AI935786 Hs 131035 ESTs, Weaklysimilar to CA24.H SS,SS,TM,PX,PH,PLDc,arres 51

430390 AB023186 Hs 241161 KIAA0969 protein PH.SSJM 51

421658 X84048 Hs 301760 frequeπm (Drosophila) homolog efhand 51

426928 AF037062 Hs 172914 retmol dehydrogenase 5 (11-cι adh_short,SS,adh_short TG 5 1

428924 AI016405 Hs 98959 ESTs, Weakly similar to JC5314 SSJM.Ixtm.c 51

458876 AI650896 Hs 195347 ESTs 51

402632 Target Exon Fz.kπngle.ig 51

413762 AW411479 Hs 848 FK506-bιndιng protein 4 (59kD) FKBPJPR.SS 5 1

419451 AI907117 Hs 90535 syntaxm binding protein 2 Sx1,SS,TM 51

456155 R85182 Hs 7175 ESTs, Weakly similar to AF1568 SS 5 1

422396 W21872 Hs 7907 ESTs, Weakly similar to T19486 51

413983 BE348384 Hs 279194 ESTs 50

447598 AI799968 Hs 199630 ESTs SSJM 50

425858 AA364923 gb EST75602 Pineal gland II Ho SS,TM,Peptιdase M10,fn2,h 50

440511 AF132959 Hs 7236 eNOS interacting protein SS,TM,MAGE,Rιbosomal_S17, 50

452661 AW449413 Hs 257152 ESTs 50

412800 AW950852 Hs 74598 polymerase (DNA directed), del homxbox,SS,efhand,hexokι 50

446603 NM.014835 Hs 15519 oxysterol binding protein-rela OxysteroLBP.SS 50

402884 ENSP00000164597 PRO0566 laminin Ntermjamiπin Nte 50

448680 AW245890 Hs 21753 JM5 protein WD40,SS,TM KOW,HLH 50

431515 NM 012152 Hs 258583 endothelial differentiation, I 7tm_1 50

427204 AA405404 Hs 215725 ESTs SS.SS 50

425169 AW292500 Hs 128514 ESTs SS 50

412940 BE295701 Hs 819 homeo box B7 homeobox,SS,homeobox,home 50

440839 AI142078 Hs 135562 ESTs SS 50

443814 BE281240 Hs 9857 carbonyl reductase 50

434243 AA628062 Hs 200358 ESTs, Moderately similar to AL SSJM 50

435605 AF151815 Hs 4973 hypothetical protein SS,TM,SS,TM,ABC tran.ABC 50

417116 Z43916 Hs 7634 hypothetical protein FU12287 SS,TM,filament,IF_taιl 50

403055 C2002219* gι|12737280|reflXP_0 50

420856 BE513294 Hs 205736 HLA class II region expressed kazal,SS,TM,ιg,pkιnase 49

405594 NMJ21949 Homo sapiens ATPase, E1-E2_ATPase,Hydrolase,SS 49

405334 Target Exon SSJM.MIP 49

419493 AF001212 Hs 90744 proteasome (prosome, mxropain PCI,SS,CDK5_xtιvator 49

413764 BE162704 gb PM1-HT0454-301299 001-d08 H SS 49

409169 F00991 Hs 50889 (clone PWHLC2-24) myosin light 49

446933 AL137659 Hs 297214 HSPC141 protein SS,TM,ank,EGF,notch,MATH, 49

409139 AI681917 Hs 3321 ESTs, Highly similar to IRX1.H SS.homxbox 49

456672 AK002016 Hs 114727 Homo sapiens, clone MGC 16327, SS.PK.PK Cmyosm head.Rh 49

420842 AI083668 Hs 50601 hypothetical protein MGC10986 SS 49

421909 NM 013375 Hs 109428 TATA-bmding protein-binding p 49

419667 AU077005 Hs 92208 a disintegπn and metalloprote disintegπn.Reprolysin.Pe 49

443496 AJ006973 Hs 9482 target of mybl (chicken) homol VHS,GAT,TM,Heme oxygenase 49

400933 NM.004347 Homo sapiens caspase ICE_p20,ICE_p10,CARD,SS,l 49

456143 H11097 Hs 61960 hypothetical protein SS.pkinase 49

427527 AI809057 Hs 153261 immunoglobulin heavy constant SS,TM,ιg 49

414265 BE410411 Hs 75864 endoplasmic reticulum glycopro 49

433933 AI754389 Homo sapiens clone TCCCIA00164 SS,TM,SS,TM,SH2,Y_phospha 49

452302 AF173867 Hs 28906 gluc∞orticoid modulatory ele SAND.SS 49

409938 AW974648 gb EST386752 MAGE resequences, SS,Adap_comp_sub,GYF 48

400845 NMJ03105* Homo sapiens sortil ldl_rxepLa,fn3,ldLrxe 48

425976 C75094 Hs 334514 NG22 protein SS,TM,pkιπase,SH2,SH3,BNR 48

452969 W92792 Hs 77575 hypothetical protein MGC3136 48

413163 Y00815 Hs 75216 protein tyrosine phosphatase, frι3,ιg,Y_phosphatase,SS,T 48

434962 AK001574 Hs 4291 golgi perepheral membrane prot 48

418572 AI751740 Hs 86172 paired related homxbox protei homxbox 48

440869 NM 014297 Hs 7486 protein expressed in thyroid lxtamase_B,SS,XRCC1_N,BR 48

453446 BE299996 gb 600944574F1 NIH .MGCJ7 Homo 48

412159 AF286598 Hs 9271 KIAA1071 protein bZIP 48

438999 AW276811 gb xp66c02x1 NCI_CGAP_Ov39 Ho 48 420233 AA256714 Hs 194864 hypothetical protein FU22578 SS 48

414576 AK000405 Hs 76480 ubiquitin-like 4 ubιquιtιn,SS,TM,G6PD,G6PD 48

433669 AL047879 Hs 80475 ESTs, Weakly similar to ALU2.H SS,TM,RNA_pol L,RasGAP,C2 48

448984 AW751955 Hs 22753 hypothetical protein FU22318 SS 48

426912 AL043054 Hs 256657 ESTs, Weakly similar to A46302 SS 48

418945 BE246762 Hs 89499 arxhidonate 5-lιpoxygeπase lιpoxygenase,PLAT,SS 48

440333 AI378424 Hs 288761 hypothetical protein FU21749 SSJM.IP frans.pkinase.pk 48

425615 AF023614 Hs 158341 transmembrane xtivator and CA TM 48

458040 BE280562 Hs 287711 hypothetical protein FU22692 48

458367 AA088470 Hs 83135 Homo sapiens, Similar to RIKEN SS,tRNA-synL2d 48

433294 AA582082 Hs 199410 ESTs 48

437671 AA536047 Hs 9850 hypothetical protein MGC1842 48

425338 H16716 Hs 182648 Homo sapiens cDNA FU 14444 fis 48

447946 AI566164 Hs 165827 ESTs SS.PTN MK,7tm 1,DAGKc,DAG 47

447205 BE617015 Hs 11006 ESTs, Moderately similar to T1 SS,TM,LRRCT,Sema 47

416880 H99640 Hs 53687 EST 47

440150 AW975738 Hs 7001 Homo sapiens, clone IMAGE 3940 SS,TM,SS,TM,Peptιdase_M22 47

426268 AF083420 Hs 168913 senne/threonme kinase 24 (St pkinase.pkmase 47

429253 Y11739 Hs 198313 winged helix nude Fork head,SS,TM,glycolytι 47

450261 AA788727 Hs 34068 ESTs, Weakly similar to A43932 SS 47

439246 AI498072 membraπe-ass∞iated tyrosme- SS.SSJM 47

419120 BE271922 ESTs, Weakly similar to zinc f SS,TM,DENN,Cytιdylylfraπs 47

416487 AW190458 Hs 79347 KIAA0211 gene product SS,zf C2H2 47

413837 AW163525 titin-cap (telethon ) SS,Methyitransf 3 47

419887 AW292562 Hs 187628 ESTs TM 47

410277 R88621 Hs 26249 ESTs, Weakly similar to T2D3.H SSJM.SS 47

415169 W42913 Hs 78089 ATPase, vxuolar, 14 kD ATP-synLF,SS,TM,CH,Fιlam 47

410892 AW809762 Hs 222056 Homo sapiens cDNA FU 11572 fis 47

407754 AA527348 Hs 288967 Homo sapiens cDNA FU14105 fis SS,TM,SS,TM,TSPN,tsp_3,SE 47

409877 AW502498 Hs 15220 zinc finger protein 106 47

431629 AU077025 Hs 265827 interferon, alpha inducible pr pkιnase,SH2,SH3 47

438800 AB037108 Hs 6418 seven transmembrane domain orp SSJM 47

420823 R96881 Hs 63609 Hpall tiny fragments Ixus 9C TM 47

418900 BE207357 Hs 3454 KIAA1821 protein SS 47

402400 Target Exon SSJM.RNase HII.bZIP.DUF2 47

419625 U91616 Hs 91640 nuclear factor of kappa light ank,SS,TM 47

433319 AA583232 ESTs SS 47

424959 NM 005781 Hs 153937 xtivated p21cdc42Hs kinase pkιnase,SH3 47

432750 NM 014440 Hs 278910 interieukin 1, epsilon IL1 47

425954 AK000633 Hs 164476 hypothetical protein FU20626 SCAN,zf-C2H2,KRAB,SS,KRAB 47

447245 AK001713 Hs 17860 hypothetical protein FU10851 E1 dehydrog 47

427101 R87591 Hs 172884 ESTs SSJM 46

447544 AA401573 Hs 288284 hypothetical protein FU22378 SSJM 46

400266 NMJ02858* Homo sapiens ATP-bi ABC traπ 46

412841 AI751157 Hs 101395 hypothetical protein MGC11352 SSJM 46

422066 AW249275 Hs 343521 malate dehydrogenase 2, NAD (m Idh.ldh C.adh short,Semιa 46

414874 D26351 Hs 77515 mositol 1,4,5-tπphosphate re TM.RYDR ITPR,ιoπJrans,MI 46

418373 AW750770 Hs 84344 CGI-135 protein SSJM.PMP22 Claudιn,20G-F 46

424487 T08754 Hs 6259 KIAA1698 protein SS,SS,TM,Glyco_hydro_31,G 46

426571 AA381642 gb EST94816 Activated T-cells 46

433941 AA620612 ESTs SS,TM,TNFR_c6 46

421717 AF230924 Hs 107187 divalent cation tolerant prate 46

450883 NM.001348 Hs 25619 death-ass∞iated protein kmas pkmase,GTP_EFTU,EFG_C,GT 46

427361 AW732480 Hs 7678 cellular retmoic xid binding SS,TM,amιnotran 1 2.LRR 46

420421 AF281133 Hs 343589 exosome component Rrp41 RNase_PH,RNase_PH_C 46

414513 AW239400 Hs 76297 G protein-coupled rxeptor km pkιnase,RGS,pkιnase_C,SS, 46

431498 AK001777 Hs 258551 aspartyl ammopeptidase SS,Peptιdase_M18,SS,TM,Y_ 46

432593 AW301003 Hs 51483 ESTs, Weakly similar to hypoth SS,TM,adh_short 46

404661 C9000306* gι|12737280|ref|XP_0 46

412790 NM_014767 Hs 74583 KIAA0275 gene product kazal.thyroglobulin 1,zf- 46

456243 AI345001 Hs 82380 menage a trois 1 (CAK assembly zf-C3HC4 46

426222 BE391706 Hs 168073 DKFZP727M231 protein GSH_synthase 46

439594 AI245026 Hs 111099 hypothetical protein MGC10974 CLP_protease 46

409114 AA070021 gb zm67h03 r1 Stratagene neuro 46

429049 AW452125 Hs 119273 KIAA0296 gene product SSJM.frypsin 46

424271 AI991887 Hs 305882 5-oxoprolιnase (ATP-hydrolysm 46

418741 H83265 Hs 8881 ESTs, Weakly similar to S41044 SS,TM,pkιnase,Actιvιn_rx 46

450493 M93718 Hs 166373 nitric oxide synthase 3 (endot flavodoxιn,FAD_bιndιng,NO 46

433074 AL045019 Hs 323462 Homo sapiens cDNA FU 11214 fis DEAD.helicase Cdsrm.Vira 46

444893 AW249312 Hs 12109 WD40 protein Cιao1 WD40 46

420508 AJ270993 Hs 98428 homx box B6 homxbox,SS,homeobox,home 46

409591 AA532963 Hs 9100 Homo sapiens cDNA FU13100 fis SS,TM,LIM,homeobox 46

456181 L36463 Hs 1030 ras inhibitor RA,SH2,VPS9,SS,TM,Nucleos 46

439270 BE268278 Hs 28393 hypothetical protein MGC2592 SSJM.HC03 cotransp 46

440104 AA132838 Hs 239894 hypothetical protein MGC2803 SS.DS 45

423279 AW959861 Hs 290943 ESTs SS 45

445087 AW893449 Hs 12303 suppressor of Ty (S cerevisiae S1,SH2,Rιbosomal_L23 pkin 45

404036 Target Exon SS,TM,cadheπn,cadheπn 45

431832 AW276866 Hs 192715 ESTs Ets.SAM PNT 45

433886 AA613596 Hs 28412 ESTs SS 45

426735 T78716 Hs 120446 ESTs Oxysterol BP.PH 45

417825 AW838994 Hs 6363 heparan sulfate 6-0 sulfofrans SSJM 45

455600 BE061053 gb QV0-BT0041-271099 037-d09 B C4 45

423858 AL137326 Hs 133483 Homosapiens mRNA, cDNA DKFZp4 SSJM 45 421680 AL031186 Hs 289106 Human DNA sequence from clone SS,SS,rrm,zf-RanBP,rrm,GA 45

408157 AA047685 Hs 62946 ESTs pkinase 45

434303 AW204058 transforming growth fxtor bet SS,TM,SSF,FG-GAP,vwa,ιnte 45

440745 AW303627 Hs 143301 ESTs 45

419344 U94905 Hs 277445 dixylglycerol kinase, zeta (1 ank,DAGKa,DAGKc,DAG_PE-bι 45

447208 BE315291 Hs 237971 hypothetical protein MGC5627 45

436163 R84938 gb yt65f04 r1 Soares retina N2 45

456856 AK001528 Hs 347285 Homo sapiens, Similar to DiGeo 45

410817 AI262789 Hs 93659 protein disulfide isomerase re SS.thiored 45

434558 AW264102 Hs 39168 ESTs SS,TM,LRRCT,LRR 45

440548 AL117408 Hs 7274 DKFZP434P1750 protein 45

450200 AW975625 Hs 173088 ESTs zf-UBP,zf-C3HC4 45

432434 AL161977 Hs 2994 PCTAIRE protein kinase 3 SS.pkinase 45

440042 AI073387 Hs 133898 ESTs SS 45

454328 AW372097 Hs 278429 hepatocellular carcinoma assx 45

458196 AI802408 ubiquitin A-52 residue πbosom SS,TM,frι3,FKBP,TPR 45

433472 AI541246 Hs 3343 phosphoglycerate dehydrogenase 2-Hxιd_DH,2-Hxιd_DH_C,M 45

408928 AW295827 Hs 255479 hypothetical protein MGC5566 A deamιnase,A_deamιπase 45

448093 AW977382 Hs 15898 2,4-dιenoyl CoA reductase 2, p adh_short,NDK 45

426272 AW450671 Hs 189284 ESTs 45

453610 AW368882 Hs 33818 RxQ prote -like 5 SS.DEAD.helicase C.SS.DEA 45

441327 AK001706 Hs 7778 hypothetical protein FU10751 SS,TM,7frn_1 45

424681 AA054400 Hs 151706 KIAA0134 gene product helιcase_C,PRK,SS,TM,7tm_ 45

443443 AI344042 Hs 9347 regulator of G-protein signall TM.Na Pi cotrans 45

426677 AW949856 Hs 97165 ESTs SS 45

412482 AI499930 Hs 334885 mitochondrial GTP binding prot SS 44

425236 AW067800 Hs 155223 stannixalcin 2 Stannracalcm.SS 44

423229 AC003965 Hs 125532 protease, serine, 26 trypsm.SS 44

412338 AA151527 Hs 69485 hypothetical protein FLJ 12436 SS,TM,TIG,Sema,PSI 44

419395 BE268326 Hs 90280 5-amιnoιmιdazole-4-carboxamιde AICARFT_IMPCHas,MGS,AICAR 44

442462 AF031405 gb AF031405 Soares fetal liver 44

439975 AW328081 Hs 6817 inosiπe tπphosphatase (nucleo Ham1p_lιke,SS 44

423876 BE502835 Hs 15463 Homo sapiens, clone IMAGE 2959 SS.efhand 44

423220 BE394920 Hs 125262 aladm WD40,TM,Actιvιn recp.pkin 44

411574 BE242842 Hs 6780 protein tyrosine kinase 9 like cofilιπ_ADF,SS,TM 44

448947 BE615408 Hs 337228 ESTs, Weakly similar to AXHU a SS,TM,ιg,pkιπase 44

407755 AI151353 Hs 29742 Homo sapiens serine palmitoyl SS,TM,amιnofran_1_2 44

414849 AW372721 Hs 291623 ESTs, Weakly similar to unname TM.pkmase 44

458171 AI420016 Hs 192090 ESTs SSJM 44

424443 AI751281 Hs 284161 hypothetical protein from EURO SS,TM,SS,TM 44

427002 AA524093 Hs 23158 ESTs SS,zf-C2H2 44

404344 C7002191* gι|5053028|gb|AAD388 SS ABC fran 44

427458 BE208364 Hs 29283 ESTs, Weakly similar to LKHU p SS.F5 F8 type C.EGFJGT 44

419764 BE262524 Hs 93183 vasodilator-stimulated phospho WH1 44

446872 X97058 Hs 16362 pyπmidinergic receptor P2Y, G 7tm_1,SS,TM 44

435615 Y15065 Hs 4975 potassium voltage-gated channe ιon_frans,KCNQ1_channel 44

403945 Target Exon 43

435593 R88872 Hs 4964 DKFZP586J1624 protein Herpes_HEPA,SS 43

421899 AJ011895 Hs 109281 Nef-ass∞iated fxtor 1 Virus HS.bZIP.G-gamma.Myo 43

425245 AI751768 Hs 155314 KIAA0095 gene product SSJM 43

423348 AA324687 gb EST27558 Cerebellum II Homo SSJM 43

452105 AA022838 Hs 6570 ESTs, Weakly similar to S10889 SSJMJBCrrm 43

431934 AB031481 Hs 272214 STG protein SS 43

429499 AA453809 Hs 99350 ESTs 43

453485 BE620712 Hs 33026 hypothetical protein PP2447 SSJM 43

459393 BE409283 Hs 193264 hypothetical protein MGC3234 43

405364 ENSP00000239138* Guanine nu e 43

428345 AI242431 Hs 118282 PAP-1 binding protein SSJM 43

435327 BE301871 Hs 4867 mannosyl (alpha-1,3-)-glycopro SS.HLH.Myc N term,Myc-LZ, 43

413053 AW9.63263 Hs 65377 ESTs, Moderately similar to Kl TM,SS,TM,EF.TS,UBA,transm 43

409983 D50922 Hs 57729 Kelch like ECH-assxiated prot BTB,Kelch,SS,TM 43

409936 AK001691 Hs 57655 hypothetical protein FLJ10829 SSJM 43

421592 AF009801 Hs 105941 bagpipe homeobox (Drosophila) homeobox.SS 43

424251 AA677466 Hs 143696 coxtivator-assxiated arginm SS,SNF2_N,helιcase_C,brom 43

414786 X78342 Hs 77313 cyclin-dependent kinase (CDC2- pkinase 43

432805 X94630 Hs 3107 CD97 antigen SS,TM,7tm 2,GPS,EGF,SS,TM 43

424927 AW973666 Hs 153850 hypothetical protein C321D24 SSJM 43

456863 T16837 Hs 4241 ESTs fusιon_gly,homeobox,TM 43

417823 R88869 Hs 102447 TSC-22-lιke PWWP 43

406621 X57809 Hs 181125 immunoglobulin lambda Ixus SS 43

431493 AI791493 Hs 129873 ESTs, novel cytochrome P450 SS,p450,SS 43

412958 BE391579 Hs 75087 Fas-xtivated senne/threonme SS.pkinase 43

431658 BE409917 Hs 266935 tRNA selen∞ysteme ass∞iated rrm.SS.RCC1 43

419579 W49529 Hs 296200 hypothetical protein AF053356 MSP domaιn,SS,TM,CUB,NTR, 43

410076 T05387 Hs 7991 ESTs SS 42

406773 AA812424 Hs 76067 heat sh∞k 27kD protein 1 HSP20.SS 42

424709 AL137589 Hs 152149 hypothetical protein DKFZp434K 42

418419 X55039 Hs 85004 centromere protein B (80kD) CENP-B.HTH 5 42

447377 X77343 Hs 334334 transcπption fxtor AP-2 alph TF.AP-2JF.AP-2 42

416931 D45371 Hs 80485 adipose most abundant gene fra C1q,Collagen,SS 42

411674 AW861123 gb RC3-CT0297-120200-014-a05 C SS 42

419073 AW372170 Hs 183918 Homo sapiens cDNA FU12797 fis SS,ιg,tsp_1,ZU5,SS,TM,Nuc 42

406867 AA157857 Hs 182265 keratin 19 filameπtbZIP.SS.filament 42

432183 AW151952 Hs 46679 hypothetical protein FU20739 SS 42 418910 Z25821 Hs 89466 Homo sapiens, Similar to dodec ECH,SS,TM,amιnotran_3,ABC 42

437300 AL040504 Hs 25063 PRO0461 protein SS,TM,pkιπase,cyclιn,F-bo 42

426615 AA400678 Hs 6473 gb zu70a11 r1 Soares.testis.NH 42

421453 AA234652 Hs 104555 neuropeptide FF-amide peptide SS,bZIP,zf-C2H2,bZIP,zf-C 42

408616 AA076248 gb zm18c10 r1 Stratagene paπcr 42

444744 BE394732 Hs 147562 ESTs SS 42

412575 AA113177 gb zm29e05 s1 Stratagene pancr TM.ER lumen_rxept 42

429542 AF038660 Hs 206713 UDP-Gal betaGlcNAc beta 1,4- g Galxtosyl_T_2,ιg,SS,TM,A 42

435995 BE260415 Hs 348198 hypothetical protein FU20262 42

451585 AK001171 Hs 326422 hypothetical protein MGC4549 SS.Metallophos 42

456153 AW972270 Hs 144054 ESTs SSJM 42

455340 AW901435 gb RC0-NN 1012-270300-031-a10 N 42

457268 AW272279 ESTs, Moderately similar to AL 42

432311 BE083080 Hs 274323 similar to sialyltransferase 7 Glyco_transf_29 42

409656 NMJ05133 Hs 288626 RCE1, prenyl protein protease Abι,SS,CPSase L_chaιn,HMG 42

424919 BE314461 Hs 153768 U3 sπoRNP-assxiated 55-kDa pr WD40,SS,KH-domaιn 42

416528 H65052 Hs 337621 ESTs 42

415137 AI634834 Hs 72451 Homo sapiens PAC clone RP5-108 42

417334 AA337572 Hs 157240 hypothetical protein MGC4737 SSJM.ion trans 42

451920 AA224483 Hs 27239 DKFZP586K0524 protein SS,TM,SS,TM 42

413049 NM 002151 Hs 823 hepsm (transmembrane protease frypsιn,SS,TM,ATP1G1_PLM_ 42

458988 AW410431 Hs 283670 CGI-119 protein 42

406964 M21305 FGENES predicted novel sxrete 42

451595 AW965569 Hs 20996 ESTs SS.WD40 42

449728 AI820751 Hs 107635 ESTs SS 41

453245 T99801 Hs 339751 ESTs TM.ABC fran 41

432238 AL133057 Hs 274135 Homo sapiens mRNA, cDNA DKFZp4 WD40.LRR 41

430037 BE409649 Hs 227789 mitogen-xtivated protein kma pkinase 4 1

442196 AI902646 Hs 31844 hypothetical protein FU 12586 SS.SCAN 41

425251 Z22521 Hs 155342 protein kinase C, delta pkιnase,DAG_PE-bιπd,pkιπa 4 1

415014 AW954064 Hs 24951 ESTs 4 1

440088 BE559877 Hs 183232 hypothetical protein FLJ22638 SS,zf-C3HC4,SPRY,zf-B_box 41

418837 U48263 Hs 89040 prepron∞iceptin Opiods neuropep.SS 41

410239 AI568350 Hs 61273 hypothetical protein MGC2650 SS.ARTJM 41

446975 BE246446 Hs 16695 ubiquitm-xtivating enzyme E1 ThiF.UBACT 41

453968 AA847843 Hs 62711 High mobility group (nonhiston SS.HMG box 41

448241 AW811064 gb MR2-ST0131-211099-008-C06 S SS 4 1

441455 AJ271671 Hs 7854 zinc/iron regulated transporte Zιp,SS,TM,Cytιdylyltransf 4 1

450848 AI677994 Hs 428 fms-related tyrosine kinase 3 flt3 lιg,SS,Rιbosomal L13 41

429218 AA225065 Hs 198269 Target CAT SS.Nop 41

425437 AK000482 Hs 181780 hypothetical protein FLJ20241 41

406613 Target Exon SS,pkιnase,LRR,LRRCT,Rιbo 41

431239 AL039971 Hs 251216 hypothetical protein DKFZp434A ank,WH2 41

436057 AJ004832 Hs 5038 neuropathy target esterase cNMP_bιndιng,SS,TM,cNMP_b 41

415193 AL048891 Hs 12185 hypothetical protein MGC14333 SS,TM,amιnotran_1_2,LRR 41

424619 BE387282 Hs 207443 hypothetical protein MGC10848 41

432968 BE614192 Hs 279869 melanoma-associated antigen re SS,TM,RGS,DIX 4 1

428156 BE269388 Hs 182698 mitxhondπal πbosomal protei SS 41

414084 AW168771 Hs 71574 hypothetical protein FU 14926 SS,P5CR,EF1BD 41

424964 AW161271 Hs 153961 ARP1 (xtm-related protein 1, xtm.SS 41

431410 AW299534 Hs 105739 ESTs 41

435968 AW161481 Hs 111577 integral membrane protein 3 TM 41

432351 AI270313 Hs 127762 hypothetical protein MGC12982 41

426120 AA325243 Hs 166887 copme I C2,SS,amιnofran_5 41

416877 BE386266 Hs 85658 hypothetical protein FU23436 41

425970 AK001500 Hs 165186 hypothetical protein FU 13852 SS,P5CR,Epιmerase,zf-C2H2 41

434848 BE256304 Hs 32148 AD-015 protein SS,TM,SS,TM,LRR,P,Peptιda 41

458715 AK000973 Hs 16725 hypothetical protein FLJ10111 lBR,zf-C3HC4,SS,TM IRF,CK 41

435851 AA700946 ESTs 41

425538 BE270918 Hs 164026 Homo sapiens, clone IMAGE 3534 SS.SNF2 N.helicase C.brom 41

444416 AW288085 Hs 11156 hypothetical protein zf-C3HC4,SpoA,PHD,TM,syna 40

426831 BE296216 Hs 172673 S-adenosylhomxysteme hydrola AdoHcyase.SS 40

444596 BE560662 Hs 11417 Rab xceptor 1 (prenylated) SSJM.Iig chan ANF rxept 40

439685 AW956781 Hs 293937 ESTs, Weakly similar to FXD2_H SS.PWWPJSC22 40

447402 H54520 Hs 18490 hypothetical protein FU20452 SSJM 40

450184 W31096 Hs 237617 Homo sapiens, clone IMAGE 3447 SS 40

426068 AF029778 Hs 166154 jagged 2 DSL,EGF,vwc,granulιn,SS,T 40

459255 AI493244 Hs 239500 hypothetical protein MGC13114 SS 40

403182 Target Exon SS 40

432078 BE314877 Hs 24553 hypothetical protein FU12541 SSJM 40

459167 BE504370 ESTs, Weakly similar to CA13.H SS 40

452747 BE153855 Hs 61460 Ig superfamily rxeptor LNIR SS,TM,ιg,HLH 40

444633 AF111713 Hs 286218 juπctional adhesion molxule 1 ιg,SS,TM,HLH 40

434171 BE247688 Hs 347349 KIAA0948 protein 40

422155 AW249152 sirtuin (silent mating type in SIR2,HLH,Myc_N_term,Myc-L 40

433262 AI571225 Hs 284171 KIAA1535 protein SSJM cNMP bindiπg.ionjr 40

442599 AF078037 Hs 324051 RelA-ass∞iated inhibitor SH3,ank,SS,TM,HHH,ιg 40

452500 AW373011 Hs 54558 hypothetical protein FU22222 40

437563 AI217204 Hs 144968 ESTs 40

432234 AA531128 Hs 115803 ESTs SS 40

433135 AA443873 Hs 110477 dolichyl-phosphate maπnosylfra 40

447495 AW401864 Hs 18720 programmed cell death 8 (apopt pyr redox.SS.Ets 40

452857 BE072814 Hs 258519 ESTs, Moderately similar to S6 SS 40

427834 AA506101 Hs 285813 hypothetical protein FU11807 SSJM 40 418963 BE304571 Hs.89529 aldo-keto reductase family 1, aldo keLred 4.0

437340 AL353935 Hs.135917 hypothetical protein DKFZp761D TBC,bZIP,WD40,WD40 4.0

455928 BE170313 gb:QV4-HT0536-040500-193-g02 H SS 4.0

400607 Target Exon SS.hom∞box 4.0

424825 AF207069 Hs.153357 procollagen-lysine, 2-oxogluta 20G-Fell_Oxy,Glycos_trans 4.0

438143 BE500981 Hs.269652 ESTs 4.0

433173 Z35093 Hs.3196 surfeit 1 SURF1,SS,TM,SURF1,SURF4 4.0

412550 R52452 Hs.26370 gb:yg80g07.r1 Soares infant br 4.0

TABLE 23B:

Pkey: Unique Eos probeset identifier number CAT number: Gene cluster number Accession: Genbank xcession numbers

Pkey CAT Number Accession

408215 10478J BE614290 AA307674 N35629 AA338538 AI193603 AA781096 A1680061 AI613258 AW276647 BE221263 AI348910 AI985031 AI090078 AI359617

AA666391 AI160210 AI446461 AI355345 A1343638 AI343640 AI275091 M78746 AW262795 AW250002 AA503756 AI934519 AW272086 N26520

AA626639

408294 1050553 1 BE141732 U75823 BE141331 AW178416 AW178430 BE141343 BE141298 BE141702 BE141285

409114 110088 1 AA070021 AA126205AA082771 AA102169 AA083530 AA082183 AA115915AA085147 AA125905 AA063336 AA079206

409164 110421 1 AA706639 AA064707 AL036920 AI651598

409616 114348 1 AA076248 AA120958 AA122152 AA076249

409938 116091 1 AW974648 AA652153 AA649671 AA078582

409960 116270.1 BE261944 AA715461 AA318136 AA134972 AA319849 W04622 AI291655 AW879092 AA130778 BE314003 AA908246 AW960808 AA385346

AA205977 C02043 AA13505J AA078870 AA377395 AA318795 AA318785 AA319160 BE000960 AW370250 AW370244 T85930 AA759250

A1567682 AA932839 AI056920

410445 120374 2 AA199830 AI143895 AW961629 AA322482

411219 1236055 1 AW832917 AW832913 AW832906 AW832788 AW832915 AW832776

411674 1253746.1 AW861123 AW861125 AW856717 AW861116 AW856706 AW856788 AW856774 AW856787 AW856780 AW856782 AW856789 AW856772

AW856784 AW856786 AW856776 AW856635 AW856767

412091 1276564 1 R06185 AW891805 AW901892 AW901895

412173 1280870 1 T71071 AW902279 AW897608

412575 130769 1 AA113177 AW894515 AA113847

413534 1375357 1 BE146961 BE146780 BE146788 BE146967 BE146774 BE146963 BE146907

413564 1376722 1 BE260120 BE148538

413764 1387163 1 BE162704 BE162705 BE162732 BE162702 BE162694

413837 139363.1 AW163525 AW163255 AW163385 AI929359 BE279279 AA132590 AW157329 AA584408 AW157252 AI692198 AW003514 T24436 AI765658

AW157459 A1810740 AI659582 AI969924 AI929284 AI340993 AI349083 AW299522 AW664650 AW299513 AA132529 AI340991 AI912836

AI341293 AI650609 AA279

414413 . 1443696 1 BE294877 BE294759

415126 1523506 1 D60945 D61346 D81568 D80539

419120 182026 1 BE271922 N54771 AA234233 AA471354 BE171081 AA253482 AA470113 AA824327 H24470 AW504757 N51688 AI400700 AA578548 AA714130

AA609917 AW780349 AW664465 AW467553 AW571643 AA469943 AW474826 AA767165 AA326817 AA593859 AW952245 AW341739 AA805093

AA779455 AW016655

422155 21235.1 AW249152 AW249153 BE298958 AW192872 AF095714 R05553 AF083107 AF160214 NM 012237 BE258447 BE253088 AA297721 H68948

W39153 AA070372 H14246 AL079367 R24561 AW403997 AA297034 AA297092 F11858 AI372597 AA297787 Z42780 AA297072 T81280 T83544

AA297053 H26063 AA26

423348 227276 1 AA324687 AA325155 AW962038

425858 257265 1 AA364923 AW963483 BE182774 C21461

426571 269283 1 AA381642 AA381664 AW963560 AW949848 AA381728 AA381608

427326 277229 1 AI287878 A1804160 AA400787

428092 286920 1 AW879141 AA421182 AI734104 AI733923 AA430600

429720 308153 1 M79091 AA773950 AA586573 AA457225

430168 313927 1 AW968343 AA468507 AI478223 AW513008 AI762122 AI554512 AA862642 AA468976

431424 333110 1 AI222969 AA806560 AA504839 AA805261

433319 363095 1 AA583232AA601715

433933 377703 1 AI754389 AW295190 AI056058 AI056059 AI863364 AI863355 AW131720 AI674922 AI949042 AI990060 AI623178 AW469497 AA620354

433941 377883 1 AA620612 AA994983 AA994990

434303 383224 1 AW204058 AI424379 AI669663 AA629077 AW613033

434743 3925.1 AI363410 AI356019 H00141 T78748 AL049365 AL079911 AI750972 Z42602 AW452523 AI223826 AA215407 AI633829 AA292122 N42783

AW505595 AF086096 N90340 N63271 AA131836 AW607273 AA527132 T32315 AA421961 T34951 AW966080 M78807 N31947 AA521151

AA278866 AA044784AA700

434796 393400 1 AA812046 AW974514 AA764999 AA649302

435851 411522 1 AA700946 AA702712 AA947620

436163 41515 6 R84938 AL047151 AA310309 AW063200 AI569528 AI307823 N49975

437215 43473 1 AL117488 AL044479

438999 467686 1 AW276811 AA829050 AA829190

439246 47021.3 AI498072 AW251083 AA985226 AA852987 AI392809 AA206609 AW190187 AA555262 AF086057 F35814 AW516382 AA377885 N50847 F27148

AA731186 AA417728 AI003145

440317 49187 1 BE561888 BE560615 BE562102

442462 543232.1 AF031405 H73415

442472 543371 1 AW806859 AW806852 AF049582

445625 64558 1 8E246743 AA436942 AW024744 AW242177 AA975476 AW385185 R07536 R73462 AV654529 T57442 AI399986 R50073 R48743 AI769689

AI863005 AA317806 AI678000 AW189963 AI986207 AW471273 R73463 AI335104 AI590161 AI469257 AI954604 H21954 T25141 AA856793

R50074 AI708253 AI2

445631 6457.1 AK001822 AW860325 AA335296 AW965531 AW130957 AW193951 AI347975 AW081323 AW662527 AI343924 AI380749 AA938153 T66966

AI655000 AW418837 AI380485 AA410698 AI520726 BE501355 AI637925 AW779200 AI524755 AW593995 AI336927 AI336928 AI357036 R60592

H19058 R11124T1

447128 70934J AI271898 BE048502AI452509AI244810 X84721 AI858001 AI553937 AA149853 H00719AI765259 AW973696 F25787 F35749 AI568815

AW015380 AA554539 C00201 AA961610 AW059537 R77127

448241 756181.1 AW811064 AW811160 AI478413 448993 79225.1 AI471630 BE540637 BE265481 AW407710 BE513882 BE546739 AA053597 BE140503 BE218514 AW956702 AI656234 AI636283 AI567265

AW340858 BE207794 AA053085 R69173 AA292343 AA454908 AA293504 AI659741 AI927478 AA399460 AI760441 AA346416 BE047245

AA730380 AA394063 AA454 453446 967533 1 BE299996 BE297115 BE270415 BE295214 BE296526

454682 1228976 1 AW816029 AW813292AW816156 AW813333 AW816159 AW813302AW813344AW813172

455035 1249762 1 AW851734 AWB51676AW851693 AW851713 AW851722AW851616AW851731 AW851618 AW851648 AW852215

455340 1283604 1 AW901435 BE094527

455557 1325974 1 AW995839 AW995907

455600 1335877 1 BE061053 BE008959 BE008957 BE091618

455885 1380385 1 BE153524 BE153576 BE153583

455928 1383899 1 BE170313 BE158339 BE158290

456573 201205 1 AI279811 AI301071 A1214696 AI279813 AA588460 AA287256 BE171665

457268 310453 1 AW272279 AA461542 AA460615

457978 448900 1 AA776638 BE439540

458196 503719 1 AI802408 AA907424 AI279233 AI302762 N33153 BE045678 A1863332 AW173558 AI302328 Z20793 D25594 BE326823

459167 92053 1 BE504370 AI243453 AI809556 AI702878 AI702163 AI300626 AW072219 AI369492 AI349587 AW779061 W78149 AA055693 AA974162 AI394380

AI830098 AW054857 AI870008 AW207658 AW665508 AW300595 AI192992 AW628019 AI274365 AA906922 N92547 AW054727 AW206667

AW136707 AW13761

459271 969257.1 AL045934AL039532 H55631

TABLE 23C

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham I et al " refers to the publication entitled The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495 Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons

Pkey Ref Strand NLposition

400460 8389428 Plus 35559-36295'

400607 9887666 Plus 3112-4159

400833 8705148 Minus 187599-188138

400845 9188605 Plus 34428-34612

400923 7637836 Minus 94518-94659

400933 7651935 Minus 105330-105503

401210 7712287 Plus 166969-167133,169760-169877,171563-171733

401264 9797154 Plus 130810-130927,133367-133504

401278 9799936 Plus 98428-98573

401609 7705041 Minus 9877-11997

401674 7689903 Plus 138786-138927,139157-139298,139440-139599,139960-140159

401724 7656694 Plus 150063-150241

402197 8576113 Plus 199466-199585

402365 9454515 Minus 70928-71185

402393 9929688 Pius 19813 20084,20163-20263

402400 9945145 Minus 80123-80322

402632 9931268 Plus 101166-101419

402884 9926562 Plus 47980-48191

402916 7406502 Minus 361474,541-687

403055 8748904 Minus 109532-110225

403128 7331426 Plus 122884-123018,123134-123283,123372-123695,123779-123940,124059-124256

403182 9838273 Plus 102163-102345,102545-102725

403938 7711795 Plus 48636-48822

403945 7711869 Minus 32141-32263

404036 8567760 Minus 65247-67529,112537-114863

404333 9802821 Minus 137948-138024,138111-138300

404343 9838093 Plus 122664-122931

404344 9838093 Plus 127865-128384

404365 9964977 Plus 50151-50319,50859 51098

404661 9797073 Plus 33374-33675,33769-34008

404757 7706327 Plus 100933-101083,101580-101782

404807 4165210 Minus 124246-124422

405334 3135285 Plus 139386-139856

405346 2981263 Plus 101982-102171

405364 2281075 Minus 48325-48491,49136 49252

405371 2078469 Minus 47657-47766,48461-48596

405594 6960456 Plus 161628-161734,162823-163014,164439-164652

405928 7717155 Minus 2923-3209

406230 4760409 Plus 71716-72515

406244 7417725 Plus 39422-39595

406301 8575868 Plus 57291-57494

406487 7711306 Plus 82039-82902

406495 7711328 Minus 174661-174978

406613 2957168 Plus 5029-5147

Table 24A lists about 117 genes down-regulated in ovanan cancer compared to non-malignant adult ovanes These were selected as for Table 23A, except that the numerator was set to the 75th percentile amongst vaπous non-malignant ovary spximens, the denominator was set to the 96th percentile value amongst various ovarian cancers, the numerator was greater than or equal to 75 units, and the ratio was greater than or equal to 20 (i e , 2-fold downregulation in tumor vs normal ovanes)

TABLE 24A

Pkey Unique Eos probeset identifier number

Ex Accn Exemplar Accession number, Genbank xcession number

UG ID UniGene number

Title UniGene gene title

Protein Dom Predicted protein domain

R1 Ratio of normal ovanes to tumor Pkey Ex Axn UG ID Title Protein Dom R1

428232 BE272452 Hs 183109 monoam e oxidase A Ammo oxidase.pyr redox.F 169

433563 AI732637 Hs 277901 ESTs SS 108

444931 AV652066 general transcπption fxtor I SS.GIypican 87

451573 AW130351 ESTs SS 83

429570 BE242256 Hs 2441 KIAA0022 gene product Ixtin cSSJM 79

453510 AI699482 Hs 42151 ESTs SS 75

410295 AA741357 πidogen (eπxtm) SS.EGF.tdl rxepLb.thyro 69

438549 BE386801 Hs 21858 tπnucleotide repeat contamin SS,serpιπ,SS,WD40,FYVE 65

407969 AA046217 Hs 105370 ESTs SS,Pep_M12B_propep,Reprol 62

414541 BE293116 Hs 76392 aldehyde dehydrogenase 1 famil aldedh 60

448438 BE613081 Hs 24654 Homo sapiens cDNA FU 11640 fis 57

441422 R43777 Hs 21364 ESTs SSJM 51

413391 AI223328 Hs 75335 glycine amidmotransferase (L- Amidinotransf 39

428022 Z39686 Hs 27865 ESTs SS 36

423044 AA320829 Hs 97266 protxadheπn 18 36

416039 AA376989 Hs 78989 alcohol dehydrogenase 5 (class adh zmcHCV NS4a,TM,adh_ 35

452854 AA437061 Hs 14060 prokineticin 1 precursor SS 34

436772 AW975688 metallothionem 1E (functional SS,TM,7tm 2.HRM 32

415162 AF035718 Hs 78061 fraπscπption fxtor 21 HLH 32

427794 AA709186 Hs 99070 ESTs SS 31

433072 AI928037 Hs 158832 ESTs SS 3 1

418318 U47732 Hs 84072 transmembrane 4 superfamily me fransmembrane4 29

410059 NM 007038 Hs 58324 a disiπtegnn-like and metallo Reprolysιn,tsp 1,Pep M12B 29

431933 AI187057 Hs 132554 ESTs TM.SSJM 29

420303 AA258282 Hs 278436 KIAA14 4 protein 28

438780 M64936 gb Homo sapiens retmoic acid- 28

427661 AA410292 Hs 104761 ESTs SS.wnt 28

437342 AW903297 Hs 236438 hypothetical protein DKFZp761K Sec7,PH 28

453828 AW970960 Hs 293821 ESTs SS.Pep M12B propep.Reprol 27

418444 AI902899 Hs 85155 butyrate response fxtor 1 (EG zf-CCCH,SS 27

453767 AB011792 Hs 35094 extracellular matπx protein 2 vwc,LRR,SS,LRR 27

413624 BE177019 Hs 75445 SPARC-like 1 (mast9, hev ) kazal.SS.kazal 27

413305 NM 000426 Hs 323511 Homo sapiens cDNA FLJ23176 fi lammιn_B,lamιnιn_EGF,lam 27

414504 AW069181 Hs 115175 sterile alpha motif and leucm SS,pkιnase,SAM 27

439897 NM 015310 Hs 6763 KIAA0942 protein Sec7,PH 27

421639 NM 012082 Hs 106309 Friend of GATA2 SS 27

442498 U54617 Hs 8364 Homo sapiens pyruvate dehydrog HATPase_c,HATPase_c 26

410494 M36564 Hs 64016 protein S (alpha) EGF.Iamiπin G.gla 26

452958 AA883929 Hs 40527 ESTs SS 26

449648 AW205607 Hs 253499 ESTs SS 25

435519 AI218950 Hs 125461 hypothetical protein FLJ11539 SS 25

433690 AI373949 Hs 279610 hypothetical protein FLJ10493 SS 25

424319 AW961026 Hs 96752 ESTs, Weakly similar to ALU8 H 25

420174 AI824144 Hs 199749 ESTs 25

421709 AA159394 Hs 107056 CED-6 protein PID.Herpes UL6 24

417622 AW298163 Hs 82318 WAS protein family, member 3 WH2 24

453655 AW960427 Hs 342874 transforming growth factor, be SS,TM,zona_peIlucιda 24

408468 AI909712 phosphatidylmositol transfer SS,PX,PH,PLDc,PH,PLDc,PX 24

400829 C11000244 gι|11056030|reflNP_0 SS,TM,SS,TFIID_30kD 23

453125 AW779544 Hs 115497 hypothetical protein FU22655 ras 23

437862 AW978107 Hs 5884 Homo sapiens mRNA, cDNA DKFZpδ HLH 23

425462 AI491852 Hs 46783 Homo sapiens cDNA FU22382 fi 23

417094 NM.006895 Hs 81182 histamine N methyltransferase Acyl-CoA_dh 23

403247 Target Exon 23

441916 AA993571 ESTs 23

422746 NM 004484 Hs 119651 glypican 3 Glypican.SS 23

416777 AF146760 Hs 79844 DKFZP564M1416 protein SS.GTP CDCSS 23

409403 AA668224 Hs 6634 Homo sapiens cDNA FU22547 fi SSJM 23

418956 AA234831 KIAA0788 protein SS 23

410073 AW408163 Hs 58488 catenm (cadhenn-associated p Vinculin.Stathmm 23

419461 AI452601 Hs 288869 nuclear rxeptor subfamily 2, hormone_rx,zf-C4,hormone 23

429319 AL023754 Hs 199068 similar to calcium/calmodulin SS.pkinase 22

452123 AI267615 Hs 38022 ESTs SS 22

453305 R39224 Hs 267997 EHM2 gene 22

416157 NM 003243 Hs 342874 transforming growth fxtor, be zona_pellucιda,SS,TM,zona 22

406637 U14966 Hs 180946 πbosomal protein L5 Ribosomal L18p 22

414466 AA349211 Hs 76205 cytochrome P450, subfamily XIA p450 22

408915 NM 016651 Hs 48950 heptxellular carcinoma novel SS 22

420929 AI694143 Hs 326248 programmed cell death 4 MA3.LRR 22

456972 AI054347 Hs 2017 πbosomal protein L38 SSJM 22

409549 AB029015 Hs 54886 phospholφase C, epsilon 2 C2.PH.PI-PLC-Y.PI-PLC-X 22

410209 AI583661 Hs 60548 hypothetical protein PR01635 SS,TM,Fork head 22

449500 AW956345 Hs 12926 ESTs SSJM 22

447806 W03616 Hs 10432 ESTs, Weakly similar to I38022 2 1

441712 AW391927 Hs 7946 KIAA1288 protein 21

445025 AI768895 Hs 295727 ESTs, Weakly similar to ALUB H SS,BAG,UPF0001 21

444161 N52543 Hs 142940 ESTs SS 2 1

427156 BE621719 Hs 173802 KIAA0603 gene product SSJMJBC 21

436995 AI160015 Hs 125489 ESTs SS,TM,RasGEF,xtιn,RasGEF 21

408443 N33937 Hs 10336 ESTs SS 21

448274 AI268097 Hs 67317 Homo sapiens cDNA FU11775 fis 21

426354 NM 004010 i Hs 169470 dyslrophin (muscular dystrophy ZZ,CH,WW,spxtπn,bZIP,SS 2 1

443906 AA348031 Hs 7913 ESTs 2 1 444815 AA151539 Hs 1227 ammolevuliπate, delta-, dehyd SS,ALAD 21

420728 AA767718 Hs 93581 hypothetical protein FU10512 SS,TM,Sema,PSI,ιg 2 1

404245 NM_007116* fibπnogen C,fn3,SS 21

436420 AA443966 Hs 31595 ESTs SS,TM,PMP22_Claudιn,SS,TM 21

410066 AL117664 Hs 58419 DKFZP586L2024 protein 20

414476 AA301867 Hs 76224 EGF-contaming fibulm like ex EGFJILSS 20

424137 AA335769 Hs 16262 ESTs 20

447659 AA017472 Hs 107260 hypothetical protein DKFZp586H SS 20

444862 AI209158 Hs 143929 ESTs SSJM 20

426086 T94907 Hs 188572 ESTs PH.CH.spxtπn 20

436080 AI684710 Hs 201645 ESTs SS,ATP-synLC 20

424651 AI493206 ESTs SS 20

432939 AL038924 Hs 279849 KIAA0438 gene product zf-C3HC4,myosιn_head,DIL, 20

449088 AI654048 Hs 196556 ESTs SS,MACPF,sushι,ldl_rxept 20

428642 NM 014899 Hs 10432 KIAA0878 protein BTB.ras 20

419577 L36531 Hs 91296 integπn, alpha 8 TM,ιπtegπn_A,FG-GAP 20

450435 AI695975 Hs 201805 ESTs laminin B.laminm EGF.Iam 20

450696 AI654223 Hs 16026 hypothetical protein FLJ23191 SS 20

421255 BE326214 Hs 93813 ESTs TM 20

432467 T03667 Hs 239388 Human DNA sequence from clone SS 20

408654 BE018882 Hs 46721 UCC1 protein SS,Ependymιn,SS 20

412611 AA732036 Hs 164478 hypothetical protein FLJ21939 20

453355 AW295374 Hs 31412 myopodm 20

424665 AW368576 Hs 139851 caveolm 2 SS,TM,Caveolιn,Cav∞lιn 20

458147 AW752597 gb IL3-CT0214-161299 045-B06 C SSJM.PMM 20

447566 N50432 Hs 102648 ESTs ' 20

414496 W73853 ESTs SS,TM,pkιnase,F5 F8 type 20

425618 AW119112 Hs 9052 Homo sapiens cDNA FU22042 fi SSJM 20

415166 NM 003652 Hs 78068 carboxypeptidase Z Zn carbOpept,Fz,Dιoxygena 20

422157 AW957295 Hs 112318 62 kd protein SS 20

450253 AL133047 Hs 24715 Homo sapiens mRNA, cDNA DKFZp4 SH3 20

418919 AA232635 ESTs SS.DUF25 20

444846 AI871055 Hs 148477 ESTs SSJM 20

418781 T41160 Hs 8404 ESTs 20

TABLE 24B

Pkey Unique Eos probeset identifier number CAT number Gene cluster number Accession Genbank xcession numbers

Pkey CAT Number Accession 408468 106033 1 AI909712 AL039752 BE000369 AA376876 N75269 AA345398 AA349053 AW960062 R76169 R70638 AA054770 AI378587 AI338002 AI762398

N47873 AI066549 AI474112 AW450680 AA668668 R76114 AW242828 N58855 AW080313 AI378491 AI807102 AA417043 AI565444 AW263286

AW297099

410295 11922 2 AA741357 AI870000 W75997 H50726 AV658709 AI498817 AL037804 W67847 BE018553 AI033256 N76810 N31548 AI032084 N36278 AW075272

AI032081 R35753 W93372 AA700790 AI903697 N52985 R82468 AW580252 AL036760 AI052219 R36621 W07047 AA088621 AI249109 W68776

W69374AA15

414496 145392.1 W73853 AA928112 W77887 AW889237 AA148524 AI749182 AI754442 AI338392 AI253102 AI079403 AI370541 AI697341 H97538 AW188021

AI927669 W72716 AI051402 AI188071 AI335900 N21488 AW770478 W92522 AI691028 AI913512 AI144448 W73819 AA604358 N28900 W95221

AI868132 H98

418919 180623 1 AA232635 AI373703 AA233330 418956 180862 AA234831 AI700302 AA906216 AA776957 R49415 AI420777 AA666394 AI830619 AA779469 AI972390 N40980 AI094453 AA826397 AA535994

AI868257 AI804295 AA897791 AA232893 AI348680 AI356232 AA235138 F31396 AW079977 H16405

424651 241981J AI493206 AA732315 AA344619 AA904035 AW952967 AA488889 AA635644 BE245127 AA669979 AA761874 H28767 AA910081 AA837086

AA766495 W76175 AI521825 AA746092 AA743152 AI478562 H88863

436772 426854 1 AW975688 AA731063 N67084 438780 46501J M64936 AI025512 A1382987 BE061777 AA089966 BE169930T41176 AW594624 BE502415 AA121893 AI269283 T40311 AΪ684569 AA257011

AI079277 AI241318 BE327710 AW975215 AW896268 AA884990 BE327514

441916 528799 1 AA993571 AA971518 AI937262 444931 62567_ϊ AV652066 AA459880 T58512 T58561 AI651255 N49838 H87921 AW264447 AA428067 AA364094 AW955685 D62894 AW341452 AA243652

AI984618 AI816803 AI871252 AI376942 AI740496 AA452836 AI277917 AI149141 AA456147 AI784566 AI003975 AI245674 AI433703 AI200208

AI268985AI38

451573 875588 1 AW130351 AW338699 AI803973 458147 488021J AW752597 AW848781 AW849062 AW848490 AW752699 AW752604 AW752700

TABLE 24C

Pkey Unique number corresponding to an Eos probeset

Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham I et al " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495 Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons

Pkey Ref Strand NLposition

400829 8570385 Plus 152176-152616

403247 7656833 Minus 76626-77140

404245 7406725 Plus 36019-36282,37073-37813,38946-39314,40355-40651,42738-43028,43391-43696,45698-46030,5111051415,52779-53072,54648-

54935,55201-55509,55926-56240,56355-56672,57078-57401,59966-60262,62600 62926,63363-63686,66693-67025,68180-

68497,68909 69232,71372-71695,720

Table 25A provides UnigenelD, UnigeneTitle, Pkey, and Exemplar Accession for sequences in Table 26 The information in Table 25A is linked by SEQ ID NO to Table 26

Table 25A

Pkey Unique Eos probeset identifier number Ex Accn Exemplar Accession number, Genbank xcession number

UGID UniGene number

Title UniGene title

SEQ ID NO Sequence Identification number for sequences in Table 26

Pkey Ex Accn UGID Title SEQ ID NO

452838 U65011 Hs 30743 preferentially expressed antigen in mela SEQ ID NO 1-2

421478 AI683243 Hs 97258 ESTs, Moderately similar to S29539 nbos SEQ ID NO 3-4

436982 AB018305 Hs5378 spondin 1, (f-spondm) extrxellular mat SEQ ID NO 5-6

458627 AW088642 Hs 97984 SRY (sex determining region Y)-box 17 (S SEQ ID NO 7-8

422956 BE545072 Hs 122579 ECT2 protein (Epithelial cell transformi SEQ ID NO 9-10

410102 AW248508 Hs 279727 ESTs, homologue of PEM 3 [Ciona savignyi SEQIDNO 11-12

428579 NM.005756 Hs 184942 G protein-coupled rxeptor 64 SEQ ID NO 13-22

428227 AA321649 Hs2248 small inducible cytokine subfamily B (Cy SEQIDNO 23-24

451110 AI955040 Hs 265398 PAR-6 beta (partitioning defxtive 6 h SEQIDNO 25-26

428187 AI687303 Hs 285529 G protein-coupled rxeptor 49 SEQIDNO 27-28

424905 NM 002497 Hs 153704 NIMA (never in mitosis gene a) related k SEQ ID NO 29-30

433159 AB035898 Hs 150587 kinesm like protein 2 SEQIDNO 31-32

426427 M86699 Hs 169840 TTK protein kinase SEQIDNO 33-34

425371 D49441 Hs 155981 mesothelm SEQ ID NO 35-38

418506 AA084248 Hs 85339 G protein-coupled rxeptor 39 SEQIDNO 39-40

456546 AI690321 Hs 203845 KCNK15 potassium channel, subfamily K, m SEQIDNO 41-42

427344 NM 000869 Hs2142 5-hydroxytryptamιne (serotonin) rxeptor SEQ ID NO 43-44

445537 AJ245671 Hs 12844 EGF-like-domam, multiple 6 SEQ ID NO 4546

424620 AA101043 Hs 151254 kallikrein 7 (chymotryptic, stratum com SEQ ID NO 47-48

412078 X69699 Hs 73149 paired box gene 8 SEQIDNO 49-52

409178 BE393948 Hs 50915 kallikrein 5 SEQIDNO 53-54

448243 AW369771 integππ, beta 8 SEQIDNO 55-56

426514 BE616633 Hs 170195 bone morphogenetic protein 7 (osteogenic SEQIDNO 57-58

419452 U33635 Hs 90572 PTK7 protein tyrosine kinase 7 SEQ ID NO 59-60

431130 NM 006103 Hs 2719 HE4, epididymis-spxific, whey-xidic pr SEQIDNO 61-62

415539 AI733881 Hs 72472 BMP-R1B SEQIDNO 6364

423961 D13666 Hs 136348 peπostin (OSF-2os) SEQ ID NO 65-66

417433 BE270266 Hs 82128 5T4 oncofetal trophoblast glycoprotein SEQIDNO 67-68

422867 L32137 Hs 1584 cartilage oligomeπc matπx protein (pse SEQIDNO 69-70

409542 AA503020 Hs 36563 hypothetical protein FU22418 SEQ ID NO 71-72

444381 BE387335 Hs 283713 ESTs, Weakly similar to S64054 hypotheti SEQIDNO 73-74

452747 BE153855 Hs 61460 Ig superfamily rxeptor LNIR SEQ ID NO 75-76

450375 AA009647 a disintegnn and metalloproteinase doma SEQIDNO 77-78

426215 AW963419 Hs 155223 stanni∞alcin 2 SEQIDNO 7980

430044 AA464510 Hs 152812 ESTs SEQIDNO 81

447033 AI357412 Hs 157601 ESTs SEQIDNO 82-87

410418 D31382 Hs 63325 transmembrane protease, seπne 4 SEQIDNO 88-89

411274 NM 002776 Hs 69423 kallikrein 10 SEQIDNO 90-91

422260 AA315993 Hs 105484 regenerating gene type IV SEQIDNO 92-93

409041 AB033025 Hs 50081 Hypothetical protein, XPJJ51860 (KIAA119 SEQIDNO 94-95

428664 AK001666 Hs 189095 similarto SALL1 (sal (Drosophιla)-lιke SEQIDNO 96-97

404977 Insulin like growth fxtor 2 (somatomedi SEQ ID NO 98-99

427747 AW411425 Hs 180655 senne/threonme kinase 12 SEQIDNO 100-101

412140 AA219691 Hs 73625 RAB6 interacting, kinesm like (rabkmes SEQIDNO 102-103

431846 BE019924 Hs 271580 uroplakin 1B SEQIDNO 104-105

425465 L18964 Hs 1904 protein kinase C, iota SEQIDNO 106-107

432938 T27013 Hs 3132 steroidogenic xute regulatory protein SEQIDNO 108-109

421451 AA291377 Hs 50831 ESTs SEQIDNO 110-117

437478 AL390172 Hs 317432 branched chain am otransferase 1, cytos SEQIDNO 118119

411945 AL033527 Hs 92137 L-myc-2 protein (MYCL2) SEQIDNO 120-121

424078 AB006625 Hs 139033 paternally expressed 3 SEQIDNO 122-123

406400 kallikrein 8 (neuropsin/ovasin) (KLK8) SEQIDNO 124-125

428450 NM 014791 Hs 184339 KIAA0175 gene product SEQIDNO 126-127

438167 R28363 Hs 24286 chemokine binding protein 2 (CCBP2), mRN SEQIDNO 128-129

416530 U62801 Hs 79361 kallikrein 6 (neurosm, zyme) SEQIDNO 130-131

430691 C14187 Hs 157208 aπstaless-related homeobox protein ARX SEQIDNO 132-133

408081 AW451597 Hs 167409 infron of basic-helix-loop-helix-PAS pro SEQIDNO 134

411773 NM 006799 Hs 72026 protease, seπne, 21 (testisin) SEQIDNO 135-138

407792 AI077715 Hs 39384 putative sxreted ligand homologous to f SEQIDNO 139-140

428093 AW594506 Hs 104830 ESTs SEQIDNO 141-144

431630 NM 002204 Hs 265829 integπn, alpha 3 (antigen CD49C, alpha SEQIDNO 145-148

421502 AF111856 Hs 105039 solute earner family 34 (sodium phospha SEQIDNO 149-150

431441 U81961 Hs2794 sodium channel, nonvoltage-gated 1 alpha SEQIDNO 151-152

431369 BE184455 Hs 251754 sxretory leuk∞yte protease inhibitor ( SEQIDNO 153-154

436972 AA284679 Hs 25640 audin 3 SEQIDNO 155-156

429504 X99133 Hs 204238 lipxalm 2 (oncogene 24p3) (NGAL) SEQIDNO 157-158

410001 AB041036 Hs 57771 kallikrein 11 SEQIDNO 159-160

TABLE 25B

Pkey Unique Eos probeset identifier number CAT number Gene cluster number Accession Genbank accession numbers

Pkey CAT Number Accession 448243 75629J AW369771AW748174AA290801AA419198AA044331AA127909AW995442AI480343AA044582AW956159AA373451AA127965AL134913

AW994956 BE622314 BE006298 BE006312 BE006305 BE006317 BE006303 AA043906 AA234175 AA479726 450375 833271 AA009647 AA131254AA374293AW954405H04410AW606284AA151166BE157467BE157601 H04384 W46291 AW663674 H04021 H01532

AA190993 H03231 H59605 H01642 AA852876 AA113758 AA626915 AA746952 AI161014 AA099554 R69067 TABLE 25C:

Pkey: Unique number corresponding to an Eos probeset .- .

Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (Gl) numbers. "Dunham I. et al." refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al. (1999) Nature 402:489-495 Strand: Indicates DNA strand from which exons were predicted NLposition: Indicates nucleotide positions of predicted exons

Pkey Ref Strand NLposition

404977 3738341 Minus 43081-43229

406400 9256298 Plus 1553-1712,1878-2140,4252-4385,5922-6077

Table 26

Seq ID NO: 1 DNA sequence Nucleic Acid Accession #: NM_006115.1 Coding sequence: 236..1765 1 11 21 31 41 51 i i i i i i

GCTTCAGGGT ACAGCTCCCC CGCAGCCAGA AGCCGGGCCT GCAGCCCCTC AGCACCGCTC 60

CGGGACACCC CACCCGCTTC CCAGGCGTGA CCTGTCAACA GCAACTTCGC GGTGTGGTGA 120

ACTCTCTGAG GAAAAACCAT TΪTGATTATT ACTCTCAGAC GTGCGTGGCA ACAAGTGACT 180

GAGACCTAGA AATCCAAGCG TTGGAGGTCC TGAGGCCAGC CTAAGTCGCT TCAAAATGGA 240

ACGAAGGCGT TTGTGGGGTT CCATTCAGAG CCGATACATC AGCATGAGTG TGTGGACAAG 300

CCCACGGAGA CTTGTGGAGC TGGCAGGGCA GS5CCTGCTG AAGGATGAGG CCCTGGCCAT 360

TGCCGCCCTG GAGTTGCTGC CCAGGGAGCT CTTCCCGCCA CTCTTCATGG CAGCCTTTGA 420

CGGGAGACAC AGCCAGACCC TGAAGGCAAT GGTGCAGGCC TGGCCCTTCA CCTGCCTCCC 480

TCTGGGAGTG CTGATGAAGG GACAACATCT TCACCTGGAG ACCTTCAAAG CTGTGCTTGA 540

TGGACTTGAT GTGCTCCTTG CCCAGGAGGT TCGCCCCAGG AGGTGGAAAC TTCAAGTGCT 600

GGATTTACGG AAGAACTCTC ATCAGGACTT CTGGACTGTA TGGTCTGGAA ACAGGGCCAG 660

TCTGTACTCA TTTCCAGAGC CAGAAGCAGC TCAGCCCATG ACAAAGAAGC GAAAAGTAGA 720

TGGTTTGAGC ACAGAGGCAG AGCAGCCCTT CATTCCAGTA GAGGTGCTCG TAGACCTGTT 780

CCTCAAGGAA GGTGCCTGTG ATGAATTGTT CTCCTACCTC ATTGAGAAAG TGAAGCGAAA 840 GAAAAATGTA CTACGCCTGT GCTGTAAGAA GCTGAAGATT TTTGCAATGC CCATGCAGGA 900

TATCAAGATG ATCCTGAAAA TGGTGCAGCT GGACTCTATT GAAGATTTGG AAGTGACTTG 960

TACCTGGAAG CTACCCACCT TGGCGAAATT TTCTCCTTAC CTGGGCCAGA TGATTAATCT 1020

GCGTAGACTC CTCCTCTCCC ACATCCATGC ATCTTCCTAC ATTTCCCCGG AGAAGGAAGA 1080

GCAGTATATC GCCCAGTTCA CCTCTCAGTT CCTCAGTCTG CAGTGCCTGC AGGCTCTCTA 1140

TGTGGACTCT TTATTTTTCC TTAGAGGCCG CCTGGATCAG TTGCTCAGGC ACGTGATGAA 1200

CCCCTTGGAA ACCCTCTCAA TAACTAACTG CCGGCTTTCG GAAGGGGATG TGATGCATCT 1260

GTCCCAGAGT CCCAGCGTCA GTCAGCTAAG TGTCCTGAGT CTAAGTGGGG TCATGCTGAC 1320

CGATGTAAGT CCCGAGCCCC TCCAAGCTCT GCTGGAGAGA GCCTCTGCCA CCCTCCAGGA 1380

CCTGGTCTTT GATGAGTGTG GGATCACGGA TGATCAGCTC CTTGCCCTCC TGCCTTCCCT 1440

GAGCCACTGC TCCCAGCTTA CAACCTTAAG CTTCTACGGG AATTCCATCT CCATATCTGC 1500

CTTGCAGAGT CTCCTGCAGC ACCTCATCGG GCTGAGCAAT CTGACCCACG TGCTGTATCC 1560

TGTCCCCCTG GAGAGTTATG AGGACATCCA TGGTACCCTC CACCTGGAGA GGCTTGCCTA 1620

TCTGCATGCC AGGCTCAGGG AGTTGCTGTG TGAGTTGGGG CGGCCCAGCA TGGTCTGGCT 1680

TAGTGCCAAC CCCTGTCCTC ACTGTGGGGA CAGAACCTTC TATGACCCGG AGCCCATCCT 1740

GTGCCCCTGT TTCATGCCTA ACTAGCTGGG TGCACATATC AAATGCTTCA TTCTGCATAC 1800

TTGGACACTA AAGCCAGGAT GTGCATGCAT CTTGAAGCAA CAAAGCAGCC ACAGTTTCAG 1860

ACAAATGTTC AGTGTGAGTG AGGAAAACAT GTTCAGTGAG GAAAAAACAT TCAGACAAAT 1920

GTTCAGTGAG GAAAAAAAGG GGAAGTTGGG GATAGGCAGA TGTTGACTTG AGGAGTTAAT 1980

GTGATCTTTG GGGAGATACA TCTTATAGAG TTAGAAATAG AATCTGAATT TCTAAAGGGA 2040

GATTCTGGCT TGGGAAGTAC ATGTAGGAGT TAATCCCTGT GTAGACTGTT GTAAAGAAAC 2100 TGTTGAAAAT AAAGAGAAGC AATGTGAAGC AAAAAAAAAA AAAAAAAA

Seq ID NO: 2 Protein sequence Protein Accession #: NP_006106.1 1 11 21 31 41 51

I I I I I I

MERRRLWGSI QSRYISMSVW TSPRRLVELA GQS LKDEAL AIAA E PR E FPP FMAA 60

FDGRHSQT K AMVQAWPFTC LP GVLMKGQ HLHLETFKAV DGLDV LAQ EVRPRRWKLQ 120

VLDLRKNSHQ DFWTVWSGNR ASLYSFPEPE AAQPMTKKRK VDGLSTEAEQ PFIPVEVLVD 180 LFLKEGACDE LFSYLIEKVK RKKNVLRLCC KKLKIFAMPM QDIKMI KMV QLDSIEDLEV 240

TCTWKLPT A KFSPYLGQMI NLRR L SHI HASSYISPEK EEQYIAQFTS QF S QC QA 300 YVDSLFF R GR DQ LRHV MNPLETLSIT NCR SEGDVM HLSQSPSVSQ LSV SLSGVM 360 TDVSPEPLQ A ERASATL QD VFDECGI TDDQ ALLP S SHCSQLTT SFYGNSISI 420

SALQSLLQHL IGLSN THV YPVP ESYED IHGT HLERIi AYLHAR RE LCELGRPSMV 480 W SANPCPHC GDRTFYDPEP I CPCFMPN

Seq ID NO: 3 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 264..782

1 11 21 31 41 51 l l l l l !

CCCTGCTCCA GTCACACCCG GAAGCTGACT GGTCCACGCA CAGCTGAAGC ATGAGGAAAC 60

TCATCGCGGG ACTAATTTTC CTTAAAATTT AGACTTGCAC AGTAAGGACT TCAACTGACC 120

TTCCTCAGAC TGAGAACTGT TTCCAGTATA TACATCAAGT CACTGAGATC TCCAGCACCC 180

TGCCGGTGGC ACTACTGAGA GACGAGGTGC CAGGGTGGTT CCTGAAAGTG CCTGAGCCCC 240

AACTTATCAG CAAGGAGCTC ATCATGCTGA CAGAAGTCAT GGAGGTCTGG CA GGCTTAG 300

TGATCGCGGT GGTGTCCCTC TTCCTGCAGG CCTGCTTCCT CACCGCCATC AACTACCTGC 360

TCAGCAGGCA CATGGCCCAC AAGAGTGAAC AGATACTGAA AGCGGCCAGT CTCCAGGTTC 420

CCAGGCCCAG CCCTGGCCAC CATCATCCAC CTGCTGTCAA AGAGATGAAG GAGACTCAGA 480 CAGAGAGAGA CATCCCAATG TCTGATTCCC TTTACAGGCA TGACAGCGAC ACACCCTCAG 540 ATAGCTTGGA TAGCTCCTGC AGTTCGCCTC CTGCCTGCCA GGCCACAGAG GATGTGGATT 600

ACACACAAGT CGTCTTTTCT GACCCTGGAG AACTAAAAAA TGACTCCCCG CTGGACTATG 660

AGAACATAAA GGAAATCACA GATTATGTCA ATGTCAATCC AGAAAGACAC AAGCCCAGTT 720

TCTGGTATTT TGTCAACCCT GCTCTGTCTG AGCCAGCGGA ATATGATCAA GTGGCCATGT 780

GAATTCCAAA TATTTTTAAT GGGGTCCAGT TCTCTATGGA TTCTTACATT TAATTTGTAG 840

GGAAATGCCA TTTTTCCCCC TTAAACAAGG CATGGGGCTC ACAAGTCTAT GGAGACAGGC 900

CAAAAAGAAT GTGGAGAAGA AAACTGATAA ATACACAGAG GTCCTCAAGA CCCATGGACT 960

CCTGGTCTGT ACCCAAAAAA GCTGTTCGTT CCTCAAAAAC AAAAACAAGG CTTGGCTGGG 1020

AAAACAGGCC AATGCCCCGG CAAGAAAGGT TGAGATCAGA TGTTAGGAAG AACTTTCAGG 1080

TAAAGTATGA GAACTATGGA GTCCATCAGC AGAGATAGTA GTGAAGTCTC TCCCCAGGGA 1140

AAATTTTAAA AAGGTTGAAT CAGCTGTTGT AGAGTTCTAT TTGGCAATCT CATGGTTAAA 1200

TGACTTCCCT TTGAGCTCTT TAATTATTGG CAATAAACAA CTTCTTTAAA AGTTTTAAAT 1260 AAAATAGCAA CCACCACCA Seq ID NO: 4 Protein sequence

Protein Accession #: Eos sequence

1 11 21 31 41 51

I I I I I I

M TEVMEVWH G VIAWSLF LQACF TAIN Y LSRHMAHK SEQILKAAS QVPRPSPGHH 60 HPPAVKEMKE TQTERDIPMS DS YRHDSDT PSDS DSSCS SPPACQATED VDYTQWFSD 120 PGE KNDSP DYENIKEITD YVNVNPERHK PSFWYFVNPA SEPAEYDQV AM

Seq ID NO: 5 DNA sequence Nucleic Acid Accession #: AB051390. Coding sequence: 34.-2457

1 11 21 3_ 41 51

I I I I I I

AGCGGCCGCG GCACAAAGTT GGGGGCCGCG AAGATGAGGC TGTCCCCGGC GCCCCTGAAG 60

CTGAGCCGGA CTCCGGCACT GCTGGCCCTG GCGCTGCCCC TGGCCGCGGC GCTGGCCTTC 120 TCCGACGAGA CCCTGGACAA AGTGCCCAAG TCAGAGGGCT ACTGCAGCCG TATCCTGCGC 180

GCCCAGGGCA ^'CGCGGCGCGA GGGCTACACC GAGTTCAGCC TCCGCGTGGA GGGCGACCCC 240

GACTTCTACA AGCCGGGAAC CAGCTACCGC GTAACACTTT CAGCTGCTCC TCCCTCCTAC 300

TTCAGAGGAT TCACATTAAT TGCCCTCAGA GAGAACAGAG AGGGTGATAA GGAAGAAGAC 360

CATGCTGGGA CCTTCCAGAT CATAGACGAA GAAGAAACTC AGTTTATGAG CAATTGCCCT 420 GTTGCAGTCA CTGAAAGCAC TCCACGGAGG AGGACCCGGA TCCAGGTGTT TTGGATAGCA 480

CCACCAGCGG GAACAGGCTG CGTGATTCTG AAGGCCAGCA TCGTACAAAA ACGCATTATT 540

TATTTTCAAG ATGAGGGCTC TCTGACCAAG AAACTTTGTG AACAAGATTC CACATTTGAT 600

GGGGTGACTG ACAAACCCAT CTTAGACTGC TGTGCCTGCG GAACTGCCAA GTACAGACTC 660

ACATTTTATG GGAATTGGTC CGAGAAGACA CACCCAAAGG ATTACCCTCG TCGGGCCAAC 720 CACTGGTCTG CGATCATCGG AGGATCCCAC TCCAAGAATT ATGTACTGTG GGAATATGGA 780

GGATATGCCA GCGAAGGCGT CAAACAAGTT GCAGAATTGG GCTCACCCGT GAAAATGGAG 840

GAAGAAATTC GACAACAGAG TGATGAGGTC CTCACCGTCA TCAAAGCCAA AGCCCAATGG 900

CCAGCCTGGC AGCCTCTCAA CGTGAGAGCA GCACCTTCAG CTGAATTTTC CGTGGACAGA 960

ACGCGCCATT TAATGTCCTT CCTGACCATG ATGGGCCCTA GTCCCGACTG GAACGTAGGC 1020 TTATCTGCAG AAGATCTGTG CACCAAGGAA TGTGGCTGGG TCCAGAAGGT GGTGCAAGAC 1080

CTGATTCCCT GGGACGCTGG CACCGACAGC GGGGTGACCT ATGAGTCACC CAACAAACCC 1140

ACCATTCCCC AGGAGAAAAT CCGGCCCCTG ACCAGCCTGG ACCATCCTCA GAGTCCTTTC 1200

TATGACCCAG AGGGTGGGTC CATCACTCAA GTAGCCAGAG TTGTCATCGA GAGAATCGCA 1260

CGGAAGGGTG AACAATGCAA TATTGTACCT GACAATGTCG ATGATATTGT AGCTGACCTG 1320 GCTCCAGAAG AGAAAGATGA AGATGACACC CCTGAAACCT GCATCTACTC CAACTGGTCC 1380

CCATGGTCCG CCTGCAGCTC CTCCACCTGT GACAAAGGCA AGAGGATGCG ACAGCGCATG 1440

CTGAAAGCAC AGCTGGACCT CAGCGTCCCC TGCCCTGACA CCCAGGACTT CCAGCCCTGC 1500

ATGGGCCCTG GCTGCAGTGA CGAAGACGGC TCCACCTGCA CCATGTCCGA GTGGATCACC 1560

TGGTCGCCCT GCAGCATCTC CTGCGGCATG GGCATGAGGT CCCGGGAGAG GTATGTGAAG 1620 CAGTTCCCGG AGGACGGCTC CGTGTGCACG CTGCCCACTG AGGAAACGGA GAAGTGCACG 1680

GTCAACGAGG AGTGCTCTCC CAGCAGCTGC CTGATGACCG AGTGGGGCGA GTGGGACGAG 1740

TGCAGCGCCA CCTGCGGCAT GGGCATGAAG AAGCGGCACC GCATGATCAA GATGAACCCC 1800

GCAGATGGCT CCATGTGCAA AGCCGAGACA TCACAGGCAG AGAAGTGCAT GATGCCAGAG 1860

TGCCACACCA TCCCATGCTT GCTGTCCCCA TGGTCCGAGT GGAGTGACTG CAGCGTGACC 1920 TGCGGGAAGG GCATGCGAAC CCGACAGCGG ATGCTCAAGT CTCTGGCAGA ACTTGGAGAC 1980

TGCAATGAGG ATCTGGAGCA GGTGGAGAAG TGCATGCTCC CTGAATGCCC CATTGACTGT 2040

GAGCTCACCG AGTGGTCCCA GTGGTCGGAA TGTAACAAGT CATGTGGGAA AGGCCACGTG 2100

ATTCGAACCC GGATGATCCA AATGGAGCCT CAGTTTGGAG GTGCACCCTG CCCAGAGACT 2160

GTGCAGCGAA AAAAGTGCCG CATCCGAAAA TGCCTTCGAA ATCCATCCAT CCAAAAGCTA 2220 CGCTGGAGGG AGGCCCGAGA GAGCCGGCGG AGTGAGCAGC TGAAGGAAGA GTCTGAAGGG 2280

GAGCAGTTCC CAGGTTGTAG GATGCGCCCA TGGACGGCCT GGTCAGAATG CACCAAACTG 2340

TGCGGAGGTG GAATTCAGGA ACGTTACATG ACTGTAAAGA AGAGATTCAA AAGCTCCCAG 2400

TTTACCAGCT GCAAAGACAA GAAGGAGATC AGAGCATGCA ATGTTCATCC TTGTTAGCAA 2460

GGGTACGAGT TCCCCAGGGC TGCACTCTAG ATTCCAGAGT CACCAATGGC TGGATTATTT 2520 GCTTGTTTAA GACAATTTAA ATTGTGTACG CTAGTTTTCA TTTTTGCAGT GTGGTTCGCC 2580

CAGTAGTCTT GTGGATGCCA GAGACATCCT TTCTGAATAC TTCTTGATGG GTACAGGCTG 2640

AGTGGGGCGC CCTCACCTCC AGCCAGCCTC TTCCTGCAGA GGAGTAGTGT CAGCCACCTT 2700

GTACTAAGCT GAAACATGTC CCTCTGGAGC TTCCACCTGG CCAGGGAGGA CGGAGACTTT 2760

GACCTACTCC ACATGGAGAG GCAACCATGT CTGGAAGTGA CTATGCCTGA GTCCCAGGGT 2820 GCGGCAGGTA GGAAACATTC ACAGATGAAG ACAGCAGATT CCCCACATTC TCATCTTTGG 2880

CCTGTTCAAT GAAACCATTG TTTGCCCATC TCTTCTTAGT GGAACTTTAG GTCTCTTTTC 2940

AAGTCTCCTC AGTCATCAAT AGTTCCTGGG GAAAAACAGA GCTGGTAGAC TTGAAGAGGA 3000

GCATTGATGT TGGGTGGCTT TTGTTCTTTC ACTGAGAAAT TCGGAATACA TTTGTCTCAC 3060

CCCTGATATT GGTTCCTGAT GCCCCCCCAA CAAAAATAAA TAAATAAATT ATGGCTGCTT 3120 TATTTAAATA TAAGGTAGCT AGTTTTTACA CCTGAGATAA ATAATAAGCT TAGAGTGTAT 3180

TTTTCCCTTG CTTTTGGGGG TTCAGAGGAG TATGTACAAT TCTTCTGGGA AGCCAGCCTT 3240

CTGAACTTTT TGGTACTAAA TCCTTATTGG AACCAAGACA AAGGAAGCAA AATTGGTCTC 3300

TTTAGAGACC AATTTGCCTA AATTTTAAAA TCTTCCTACA CACATCTAGA CGTTCAAGTT 3360

TGCAAATCAG TTTTTAGCAA GAAAACATTT TTGCTATACA AACATTTTGC TAAGTCTGCC 3420 CAAAGCCCCC CCAATGCATT CCTTCAACAA AATACAATCT CTGTACTTTA AAGTTATTTT 3480 AGTCATGAAA TTTTATATGC AGAGAGAAAA AGTTACCGAG ACAGAAAACA AATCTAAGGG 3540

AAAGGAATAT TATGGGATTA AGCTGAGCAA GCAATTCTGG TGGAAAGTCA AACCTGTCAG 3600

TGCTCCACAC CAGGGCTGTG GTCCTCCCAG ACATGCATAG GAATGGCCAC AGGTTTACAC 3660

TGCCTTCCCA GCAATTATAA GCACACCAGA TTCAGGGAGA CTGACCACCA AGGGATAGTG 3720

TAAAAGGACA TTTTCTCAGT TGGGTCCATC AGCAGTTTTT CTTCCTGCAT TTATTGTTGA 3780

AAACTATTGT TTCATTTCTT CTTTTATAGG CCTTATTACT GCTTAATCCA AATGTGTACC 3840

ATTGGTGAGA CACATACAAT GCTCTGAATA CACTACGAAT TTGTATTAAA CACATCAGAA 3900

TATTTCCAAA TACAACATAG TATAGTCCTG AATATGTACT TTTAACACAA GAGAGACTAT 3960

TCAATAAAAA CTCACTGGGT CTTTCATGTC TTTAAGCTAA GTAAGTGTTC AGAAGGTTCT 4020

10 TTTTTATATT GTCCTCCACC TCCATCATTT TCAATAAAAG ATAGGGCTTT TGCTCCCTTG 4080

TTCTTGGAGG GACCATTATT ACATCTCTGA ACTACCTTTG TATCCAACAT GTTTTAAATC 4140

CTTAAATGAA TTGCTTTCTC CCAAAAAAAG CACAATATAA AGAAACACAA GATTTAATTA 4200

TTTTTCTACT TGGGGGGAAA AAAGTCCTCA TGTAGAAGCA CCCACTTTTG CAATGTTGTT 4260

CTAAGCTATC TATCTAACTC TCAGCCCATG ATAAAGTTCC TTAAGCTGGT GATTCCTAAT 4320

15 CAAGGACAAG CCACCCTAGT GTCTCATGTT TGTATTTGGT CCCAGTTGGG TACATTTTAA 4380

AATCCTGATT TTGGAGACTT AAAACCAGGT TAATGGCTAA GAATGGGTAA CATGACTCTT 4440

GTTGGATTGT TATTTTTTGT TTGCAATGGG GAATTTATAA GAAGCATCAA GTCTCTTTCT 4500

TACCAAAGTC TTGTTAGGTG GTTTATAGTT CTTTTGGCTA ACAAATCATT TTGGAAATAA 4560 AGATTTTTTA CTACAAAAAT G

20

Seq ID NO: 6 Protein sequence Protein Accession #: BAB18461 1 11 21 31 41 51

25 I I I I' I I

MRLSPAP KL SRTPAL ALA LPLAAALAFS DETLDKVPKS EGYCSRILRA QGTRREGYTE 60

FSLRVEGDPD FYKPGTSYRV T SAAPPSYF RGFTLIALRE NREGDKEEDH AGTFQIIDEE 120

ETQFMSNCPV AVTESTPRRR TRIQVFWIAP PAGTGCVI K ASIVQKRIIY FQDEGS TKK 180 CEQDSTFDG VTDKPI DCC ACGTAKYRLT FYGN SEKTH PKDYPRRANH WSAIIGGSHS 240

KNYVL EYGG YASEGVKQVA E GSPVKMEE EIRQQSDEV TVIKAKAQWP A QP NVRAA 300

30 PSAEFSVDRT RH MSF TMM GPSPDWNVGL SAED CTKEC GVQKWQD IPWDAGTDSG 360

VTYESPNKPT IPQEKIRPLT SLDHPQSPFY DPEGGSITQV ARWIERIAR KGEQCNIVPD 420

NVDDIVADLA PEEKDEDDTP ETCIYSNWSP WSACSSSTCD KGKRMRQRM. KAQ DLSVPC 480

PDTQDFQPCM GPGCSDEDGS TCTMSE IT SPCSISCGMG MRSRERYVKQ FPEDGΞVCT 540

PTEETEKCTV NEECSPSSCL MTEWGEWDEC SATCGMGMKK RHRMIKMNPA DGSMCKAETS 600

35 QAEKCMMPEC HTIPCLLSPW SE SDCSVTC GKGMRTRQRM LKS AELGDC NEDLEQVEKC 660

M PECPIDCE LTEWSQWSEC NKSCGKGHVI RTRMIQMEPQ FGGAPCPETV QRKKCRIRKC 720

LRNPSIQK R WREARESRRS EQ KEESEGE QFPGCRMRPW TAWSECTKLC GGGIQERYMT 780 VKKRFKSSQF TSC DKKEIR ACNVHPC

40 Seq ID NO: 7 DNA sequence

Nucleic Acid Accession #: NM_022454

Coding sequence: 205..1449

1 11 21 31 41 51

_A, I I I I I I D GCAGTGTCAC TAGGCCGGCT GGGGGCCCTG GGTACGCTGT AGACCAGACC GCGACAGGCC 60

AGAACACGGG CGGCGGCTTC GGGCCGGGAG ACCCGCGCAG CCCTCGGGGC ATCTCAGTGC 120

CTCATTCCCC ACCCCCTCCC CCGGGTCGGG GGAGGCGGCG CGTCCGGCGG AGGGTTGAGG 180

GGAGCGGGGC AGGCCTGGAG CGCCATGAGC AGCCCGGATG CGGGATACGC CAGTGACGAC 240

CAGAGCCAGA CCCAGAGCGC GCTGCCCGCG GTGATGGCCG GGCTGGGCCC CTGCCCCTGG 300

50 GCCGAGTCGC TGAGCCCCAT CGGGGACATG AAGGTGAAGG GCGAGGCGCC GGCGAACAGC 360

GGAGCACCGG CCGGGGCCGC GGGCCGAGCC AAGGGCGAGT CCCGTATCCG GCGGCCGATG 420

AACGCTTTCA TGGTGTGGGC TAAGGACGAG CGCAAGCGGC TGGCGCAGCA GAATCCAGAC 480

CTGCACAACG CCGAGTTGAG CAAGATGCTG GGCAAGTCGT GGAAGGCGCT GACGCTGGCG 540

GAGAAGCGGC CCTTCGTGGA GGAGGCAGAG CGGCTGCGCG TGCAGCACAT GCAGGACCAC 600

55 CCCAACTACA AGTACCGGCC GCGGCGGCGC AAGCAGGTGA AGCGGCTGAA GCGGGTGGAG 660

GGCGGCTTCC TGCACGGCCT GGCTGAGCCG CAGGCGGCCG CGCTGGGCCC CGAGGGCGGC 720

CGCGTGGCCA TGGACGGCCT GGGCCTCCAG TTCCCCGAGC AGGGCTTCCC CGCCGGCCCG 780

CCGCTGCTGC CTCCGCACAT GGGCGGCCAC TACCGCGACT GCCAGAGTCT GGGCGCGCCT . 840

CCGCTCGACG GCTACCCGTT GCCCACGCCC GACACGTCCC CGCTGGACGG CGTGGACCCC 900

60 GACCCGGCTT TCTTCGCCGC CCCGATGCCC GGGGACTGCC CGGCGGCCGG CACCTACAGC 960

TACGCGCAGG TCTCGGACTA CGCTGGGCCC CCGGAGCCTC CCGCCGGTCC CATGCACCCC 1020

CGACTCGGCC CAGAGCCCGC GGGTCCCTCG ATTCCGGGCC TCCTGGCGCC ACCCAGCGCC 1080

CTTCACGTGT ACTACGGCGC GATGGGCTCG CCCGGGGCGG GCGGCGGGCG CGGCTTCCAG 1140

ATGCAGCCGC AACACCAGCA CCAGCACCAG CACCAGCACC ACCCCCCGGG CCCCGGACAG 1200

65 CCGTCGCCCC CTCCGGAGGC ACTGCCCTGC CGGGACGGCA CGGACCCCAG TCAGCCCGCC 1260

GAGCTCCTCG GGGAGGTGGA CCGCACGGAA TTTGAACAGT ATCTGCACTT CGTGTGCAAG 1320

CCTGAGATGG GCCTCCCCTA CCAGGGGCAT GACTCCGGTG TGAATCTCCC CGACAGCCAC 1380

GGGGCCATTT CCTCGGTGGT GTCCGACGCC AGCTCCGCGG TATATTACTG CAACTATCCT 1440

GACGTGTGAC AGGTCCCTGA TCCGCCCCAG CCTGCAGGCC AGAAGCAGTG TTACACACTT 1500

70 CCTGGAGGAG CTAAGGAAAT CCTCAGACTC CTGGGTTTTT GTTGTTGCTG TTGTTGTTTT 1560

TTAAAAGGTG TGTTGGCATA TAATTTATGG TAATTTATTT TGTCTGCCAC TTGAACAGTT 1620

TGGGGGGGTG AGGTTTCATT TAAAATTTGT TCAGAGATTT GTTTCCCACA GTTGGATTGT 1680

CAAAACCCTA TTTCCAAGTT CAAGTTAACT AGCTTTGAAT GTGTCCCAAA ACAGCTTCCT 1740

CCATTTCCTG AAAGTTTATT GATCAAAGAA ATGTTGTCCT GGGTGTGTTT TTTCAATCTT 1800 75 CTAAAAAATA AAATCTGGAA TCCTGAAAAA AAAAAAAAAA AAAAAAAAAA AAA

Seq ID NO: 8 Protein sequence Protein Accession #: NP_071899 __^ 1 11 21 31 41 51

80 I i i i i i

MSSPDAGYAS DDOSQTQSA PAVMAG GPC PWAES SPIG DMKVKGEAPA NSGAPAGAAG 60

RAKGESRIRR PMNAFMVWAK DERKRAQQN PDLHNAE SK MLGKS KALT LAEKRPFVEE 120

AERLRVQHMQ DHPNYKYRPR RRKQVKR KR VEGGF HG A EPQAAA GPE GGRVAMDGLG 180

LQFPEQGFPA GPPLLPPHMG GHYRDCQS G APPLDGYPLP TPDTSPLDGV DPDPAFFAAP 240

85 MPGDCPAAGT YSYAQVSDYA GPPEPPAGPM HPRLGPEPAG PSIPGL APP SALHVYYGAM 300 GSPGAGGGRG FQMQPQHQHQ HQHQHHPPGP GQPSPPPEAL PCRDGTDPSQ PAE LGEVDR 360 TEFEQY HFV CKPEMG PYQ GHDSGVNLPD SHGAISSWS DASSAVYYCN YPDV

Seq ID NO: 9 DNA sequence

Nucleic Acid Accession #: NM_018098

Coding sequence: 112..2856

1 11 21 31 41 51

I I I I I I

AAGCTTGCGG CCGCCGGCGA GGAATGGCGG TATTTGTGAG AGGAGTCGGC GTTTGAAGAG 60

GTGGAACTCC TAGGGCTTTT TTGAGAGTGC TGATTTAGAA GAATACAAAT CATGGCTGAA 120

AATAGTGTAT TAACATCCAC TACTGGGAGG ACTAGCTTGG CAGACTCTTC CATTTTTGAT 180

TCTAAAGTTA CTGAGATTTC CAAGGAAAAC TTACTTATTG GATCTACTTC ATATGTAGAA 240

GAAGAGATGC CTCAGATTGA AACAAGAGTG ATATTGGTTC AAGAAGCTGG AAAACAAGAA 300

GAACTTATAA AAGCCTTAAA GACTATTAAA ATAATGGAAG TCCCTGTTAT AAAGATAAAA 360

GAAAGTTGTC CTGGAAAATC GGATGARAAA TTAATAAAAA GTGTTATTAA TATGGACATT 420

AAAGTGGGCT CTGTAAAGAT GGAGTCAGTG GAAGAATTTG AAGGTTTGGA TTCTYCGGAA 480

TTKGAAAATG TATTTKKAGK CACGGACTTT CAGGATTCTG TCTTTAATGA CCTCTACAAG 540

GCTGATTGTA GAGTTATTGG ACCACCAGTT GTATTAAATT GTTCACAAAA AGGAGAGCCT 600

TTGCCATTTT CATGTCGCCC GTTGTATTGT ACAAGTATGA TGAATCTAGT ACTATGCTTT 660

ACTGGATTTA GGAAAAAAGA AGAACTAGTC AGGTTGGTGA CATTGGTCCA TCACATGGGT 720

GGAGTTATTC GAAAAGACTT TAATTCAAAA GTTACACATT TGGTGGCAAA TTGTACACAA 780

GGAGAAAAAT TCAGGGTTGC TGTGAGTCTA GGTACTCCAA TTATGAAGCC AGAATGGATT 840

TATAAAGCTT GGGAAAGGCG GAATGAACAG GATTTCTATG CAGCAGTTGA TGACTTTAGA 900

AATGAATTTA AAGTTCCTCC ATTTCAAGAT TGTATTTTAA GTTTCCTGGG ATTTTCAGAT 960

GAAGAGAAAA CCAATATGGA AGAAATGACT GAAATGCAAG GAGGTAAATA TTTACCGCTT 1020

GGAGATGAAA GATGCACTCA CCTTGTAGTT GAAGAGAATA TAGTAAAAGA TCTTCCCTTT 1080

GAACCTTCAA AGAAACTTTA TGTTGTCAAG CAAGAGTGGT TCTGGGGAAG CATTCAAATG 1140

GATGCCCGAG CTGGAGAAAC TATGTATTTA TATGAAAAGG CAAATACTCC TGAGCTCAAG 1200

AAATCAGTGT CAATGCTTTC TCTAAATACC CCTAACAGCA ATCGCAAACG ACGTCGTTTA 1260

AAAGAAACAC TTGCTCAGCT TTCAAGAGAG ACAGACGTGT CACCATTTCC ACCCCGTAAG 1320

CGCCCATCAG CTGAGCATTC CCTTTCCATA GGGTCACTCC TAGATATCTC CAACACACCA 1380

GAGTCTAGCA TTAACTATGG AGACACCCCA AAGTCTTGTA CTAAGTCTTC TAAAAGCTCC 1440

ACTCCAGTTC CTTCAAAGCA GTCAGCAAGG TGGCAAGTTG CAAAAGAGCT TTATCAAACT 1500

GAAAGTAATT ATGTTAA AT ATTGGCAACA ATTATTCAGT TATTTCAAGT ACCATTGGAA 1560

GAGGAAGGAC AACGTGGTGG ACCTATCCTT GCACCAGAGG AGATTAAGAC TATTTTTGGT 1620

AGCATCCCAG ATATCTTTGA TGTACACACT AAGATAAAGG ATGATCTTGA AGACCTTATA 1680

GTTAATTGGG ATGAGAGCAA AAGCATTGGT GACATTTTTC TGAAATATTC AAAAGATTTG 1740

GTAAAAACCT ACCCTCCCTT TGTAAACTTC TTTGAAATGA GCAAGGAAAC AATTATTAAA 1800

TGTGAAAAAC AGAAACCAAG ATTTCATGCT TTTCTCAAGA TAAACCAAGC AAAACCAGAA 1860

TGTGGACGGC AGAGCCTTGT TGAACTTCTT ATCCGACCAG TACAGAGGTT ACCCAGTGTT 1920

GCATTACTTT TAAATGATCT TAAGAAGCAT ACAGCTGATG AAAATCCAGA CAAAAGCACT 1980

TTAGAAAAAG CTATTGGATC ACTGAAGGAA GTAATGACGC ATATTAATGA GGATAAGAGA 2040

AAAACAGAAG CTCAAAAGCA AATTTTTGAT GTTGTTTATG AAGTAGATGG ATGCCCAGCT 2100

AATCTTTTAT CTTCTCACCG AAGCTTAGTA CAGCGGGTTG AAACAATTTC TCTAGGTGAG 2160

CACCCCTGTG ACAGAGGAGA ACAAGTAACT CTCTTCCTCT TCAATGATTG CCTAGAGATA 2220

GCAAGAAAAC GGCACAAGGT TATTGGCACT TTTAGGAGTC CTCATGGCCA AACCCGACCC 2280

CCAGCTTCTC TTAAGCATAT TCACCTAATG CCTCTTTCTC AGATTAAGAA GGTATTGGAC 2340

ATAAGAGAGA CAGAAGATTG CCATAATGCT TTTGCCTTGC TTGTGAGGCC ACCAACAGAG 2400

CAGGCAAATG TGCTACTCAG TTTCCAGATG ACATCAGATG AACTTCCAAA AGAAAACTGG 2460

CTAAAGATGC TGTGTCGACA TGTAGCTAAC ACCATTTGTA AAGCAGATGC TGAGAATCTT 2520

ATTTATACTG CTGATCCAGA ATCCTTTGAA GTAAATACAA AAGATATGGA CAGTACATTG 2580

AGTAGAGCAT CAAGAGCAAT AAAAAAGACT TCAAAAAAGG TTACAAGAGC ATTCTCTTTC 2640

TCCAAAACTC CAAAAAGAGC TCTTCGAAGG GCTCTTATGA CATCCCACGG CTCAGTGGAG 2700

GGAAGAAGTC CTTCCAGCAA TGATAAGCAT GTAATGAGTC GTCTTTCTAG CACATCATCA 2760

TTAGCAGGTA TCCCTTCTCC CTCCCTTGTC AGCCTTCCTT CCTTCTTTGA AAGGAGAAGT 2820

CATACGTTAA GTAGATCTAC AACTCATTTG ATATGAAGCG TTACCAAAAT CTTAAATTAT 2880

AGAAATGTAT AGACACCTCA TACTCAAATA AGAAACTGAC TTAAATGGTA CTTGTAATTA 2940

GCACTTGGTG AAAGCTGGAA GGAAGATAAA TAACACTAAA CTATGCTATT TGATTTTTCT 3000

TCTTGAAAGA GTAAGGTTTA CCTGTTACAT TTTCAAGTTA ATTCATGTAA AAAATGATAG 3060

TGATTTTGAT GTAATTTATC TCTTGTTTGA ATCTGTCATT CAAAGGCCAA TAATTTAAGT 3120

TGCTATCAGC TGATATTAGT AGCTTTGCAA CCCTGATAGA GTAAATAAAT TTTATGGGCG 3180

GGTGCCAAAT ACTGCTGTGA ATCTATTTGT ATAGTATCCA TGAATGAATT TATGGAAATA 3240

GATATTTGTG CAGCTCAATT TATGCAGAGA TTAAATGACA TCATAATACT GGATGAAAAC 3300

TTGCATAGAA TTCTGATΓAA ATAGTGGGTC TGTTTCACAT GTGCAGTTTG AAGTATΓTAA 3360

ATAACCACTC CTTTCACAGT TTATTTTCTT CTCAAGCGTT TTCAAGATCT AGCATGTGGA 3420

TTTTAAAAGA TTTGCCCTCA TTAACAAGAA TAACATTTAA AGGAGATTGT TTCAAAATAT 3480

TTTTGCAAAT TGAGATAAGG ACAGAAAGAT TGAGAAACAT TGTATATTTT GCAAAAACAA 3540

GATGTTTGTA GCTGTTTCAG AGAGAGTACG GTATATTTAT GGTAATTTTA TCCACTAGCA 3600

AATCTTGATT TAGTTTGATA GTGTGTGGAA TTTTATTTTG AAGGATAAGA CCATGGGAAA 3660

ATTGTGGTAA AGACTGTTTG TACCCTTCAT GAAATAATTC TGAAGTTGCC ATCAGTTTTA 3720

CTAATCTTCT GTGAAATGCA TAGATATGCG CATGTTCAAC TTTTTATTGT GGTCTTATAA 3780

TTAAATGTAA AATTGAAAAT TCATTTGCTG TTTCAAAGTG TGATATCTTT CACAATAGCC 3840

TTTTTATAGT CAGTAATTCA GAATAATCAA GTTCATATGG ATAAATGCAT TTTTATTTCC 3900

TATTTCTTTA GGGAGTGCTA CAAATGTTTG TCACTTAAAT TTCAAGTTTC TGTTTTAATA 3960

GTTAACTGAC TATAGATTGT TTTCTATGCC ATGTATGTGC CACTTCTGAG AGTAGTAAAT 4020

GACTCTTTGC TACATTTTAA AAGCAATTGT ATTAGTAAGA ACTTTGTAAA TAAATACCTA 4080 AAACCCAAAA AAAAAAAAAA AAAAA

Seq ID NO: 10 Protein sequence

Protein Accession # : Q9H8V3

1 11 21 31 41 51

I I I I I I

MAENSVLTST TGRTS ADSS IFDSKVTEIS KENL IGSTS YVEEEMPQIE TRVILVQEAG 60

KQEE TKALK DIKVGFVKME SVEEFEGLDS PEFENVFWT DFQDSVFNDL YKADCRVIGP 120

PWNCSQKG EP PFSCRP YCTSMMNLVL CFTGFRKKEE LVRLVT VHH MGGVIRKDFN 180 SKVTHLVANC TQGEKFRVAV SLGTPIMKPE WIYKAWERRN EQDFYAAVDD FRNEFKVPPF 240

QDCIFSFLGF SDEEKTNMEE MTEMQGGKYL PLGDERCTH WEENIVKDL PFEPSKKLYV 300

VKQEWFWGSI QMDARAGETM YLYEKANTPE LKKSVSM S NTPNSNRKRR RLKETAQ S 360

RDTDVSPFPP RKRPSAEHS SIGSLLDISN TPESSINYGD TPKSCTKSSK SSTPVPSKQS 420

ARHQVAKELY QTESNYVNI ATIIQLFQVP EEEGQRGGP ILAPEEIKTI FGSIPDIFDV 480

HTKIKDD ED IVNWDESKS IGDIFLKYSK D VKTYPPFV NFFEMSKETI IKCEKQKPRF 540

HAFLKINQAK PECGRQS VE LLIRPVQRLP SVAL NDLK KHTADENPDK STLEKAIGSL 600

KEVMTHINED KRKTEAQKQI FDWYEVDGC PAN LSSHRS LVQRVETISIi GEHPCDRGEQ 660

VT F FNDCL EIARKRHKVI GTFRSPHGQT RPPAS KHIH LMPLSQIKKV DIRETEDCH 720

NAFALLVRPP TEQANVLLSF QMTSDELPKE N KMLCRHV ANTICKADAE N IYTADPES 780

FEVNTKDMDS TLSRASRAIK KTSKKVTRAF SFSKTPKRAL RRALMTSHGS VEGRSPSSND 840

KHVMSR SST SSLAGIPSPS LVS PSFFER RSHTLSRSTT HLI

Seq ID NO : 11 DNA sequence Nucleic Acid Accession # : XM_044166

Coding sequence: 1. .1576 1 11 21 31 51

I I I I

CTTTTGTTTC GCCATGCCTA GTCTAGTGGT ATCTGGAATA ATGGAAAGAA ATGGGGGCTT 60 TGGAGAACTA GGATGTTTCG GGGGAAGCGC TAAGGACCGA GGGCTGCTGG AAGACGAGCG 120 CGCCCTTCAG CTGGCTCTCG ATCAACTCTG CCTCCTGGGT TTGGGGGAGC CCCCCGCCCC 180 CAGGGCGGGC GAGGACGGGG GAGGTGGGGG GGGCGGCGCC CCCGCGCAGC CGACAGCCCC 240 CCCGCAGCCG GCGCCGCCGC CGCCGCCCGC GGCGCCCCCG GCCGCCCCGA CGACGGCCCC 300 CGCAGCGCAG ACGCCCCAGC CCCCCACCGC CCCCAAAGGG GCGAGCGACG CCAAGCTCTG 360 CGCTCTCTAC AAAGAGGCCG AGCTGCGCCT GAAGGGCAGC AGCAACACCA CGGAGTGTGT 420 TCCCGTGCCC ACCTCCGAGC ACGTGGCCGA GATCGTGGGC AGGCAAGGCT GCAAGATTAA 480 GGCCTTGAGG GCCAAGACCA ACACCTACAT CAAGACACCG GTGAGGGGCG AGGAACCAGT 540 GTTCATGGTG ACAGGGCGAC GGGAGGACGT GGCCACAGCC CGGCGGGAAA TCATCTCAGC 600 AGCGGAGCAC TTCTCCATGA TCCGTGCCTC CCGCAACAAG TCAGGCGCCG CCTTTGGTGT 660 GGCTCCTGCT CTGCCCGGCC AGGTGACCAT CCGTGTGCGG GTGCCCTACC GCGTGGTGGG 720 GCTGGTGGTG GGCCCCAAAG GGGCAACCAT CAAGCGCATC CAGCAGCAAA CCAACACATA 780 CATTATCACA CCAAGCCGTG ACCGCGACCC CGTGTTCGAG ATCACGGGTG CCCCAGGCAA 840 CGTGGAGCGT GCGCGCGAGG AGATCGAGAC GCACATCGCG GTGCGCACTG GCAAGATCCT 900 CGAGTACAAC AATGAAAACG ACTTCCTGGC GGGGAGCCCC GACGCAGCAA TCGATAGCCG 960 CTACTCCGAC GCCTGGCGGG TGCACCAGCC CGGCTGCAAG CCCCTCTCCA CCTTCCGGCA 1020 GAACAGCCTG GGCTGCATCG GCGAGTGCGG AGTGGACTCT GGCTTTGAGG CCCCACGCCT 1080 GGGTGAGCAG GGCGGGGACT TTGGCTACGG CGGGTACCTC TTTCCGGGCT ATGGCGTGGG 1140 CAAGCAGGAT GTGTACTACG GCGTGGCCGA GACTAGCCCC CCGCTGTGGG CGGGCCAGGA 1200 GAACGCCACG CCCACCTCCG TGCTCTTCTC CTCTGCCTCC TCCTCCTCCT CCTCTTCCGC 1260 CAAGGCCCGC GCTGGGCCCC CGGGCGCACA CCGCTCCCCT GCCACTTCCG CGGGACCCGA 1320 GCTGGCCGGA CTCCCGAGGC GCCCCCCGGG AGAGCCGCTC CAGGGCTTCT CTAAACTTGG 1380 TGGGGGCGGC CTGCGGAGCC CCGGCGGCGG GCGGGATTGC ATGGTCTGCT TTGAGAGCGA 1440 AGTGACTGCC GCCCTTGTGC CCTGCGGACA CAACCTGTTC TGCATGGAGT GTGCAGTACG 1500 CATCTGCGAG AGGACGGACC CAGAGTGTCC CGTCTGCCAC ATCACAGCCA CGCAAGCCAT 1560 CCGAATATTC TCCTAAGCCC CGTGCCCCAT GCCTCCGGGG CCCACTCCAC TGGGCCCACC 1620 CTGGACCTGT TTTCCACTAA AGCCTTTTGG AAAGCGGTGA TTTGAGGGGC AAGGTGCTTA 1680 GAGATACTCG CTCGCTGGGG AAGGGGGGAG GGAGGCAGTG GTGGCTGGAG GGTGCGCCAC 1740 TTTCAGAGCC TCTGGTCACC CTGTCCTGGA AAGATTGGGA GGGGGCCAGA CTGAAAATTT 1800 TACΓAGAGTT ACAACTCΓGA TACCTCAACA CACCCTTAAA TCTGGAAGCA GCTAAGAGAA 1860 ACTTTTGTTT TGCCAGAGGT GGCCACTAAG GCATTCTGAC GCCCTCTGCC CACCTCCCCC 1920 GCTGTGTGTC ACTCCACCCC TTCTTCCGAG GAGGGGGTGG GTAAAAGGGA GAGGGAGAAT 1980 TACCACCTGT ATCTAGAGGT GCTCTTTGCA ATCCCTAAGC CCTCTGGTCC TGACCTCCGA 2040 CCTCCCAGCT CTGTCTTGTT CCTTGTCTTT GTCTTTCTTC CCTTCCCCCT GCCCCTGCCC 2100 CTACCAGCCC AGCTTTGGGG ACACCATCCT TCTGGGGAGA AGTAGGGGGA GGAATATTTG 2160 GATGGTCCCT CCATTCCTCT TCAGGCATCT GGAGGCCCTC TCCCCCACTC CTCCAAAGAA 2220 ACATCTCAAA TTATTGATGG AATGTATCCC CATTCTCAGT GAAAATGTGA GGAGGGGACT 2280 AATACTGGGG TAAAGGGTCA AACCCCCACC TTCATCACTA TGGGCATTAT ATTTAGGGAG 2340 TAGTTCTTGG GCTGGATTTT CTGGTTGTGG AAGTGGGGGC GCCAGAGTAG TGTGTCTGCT 2400 ATTTAAAGGA GCAGGAAAGG GCGTGAGGCA GGAGGAGAGA CTGGTGGAGG GAAGAGCTGC 2460 TCCTCCCATG CAGTGCCCGA CTCCCTGCAC CCCTCTCAAC CTGACCTGAA CCTTTATTGA 2520 ATCCTTATTA GCTTGAATCC TTATTAGCTT GAATCCTCCA TGCAAATCAT GGAGTCTGTG 2580 TCCCACCTGA TGTGGTTGAG GAGAAGCCAG GTCTTCAAAG AGGGGTCAGC CTGGGGCAAA 2640 GCAGGACTGG GGGGAGGTGG GCAGCAGGGC CTATTCTGAG AATCACATAT TGTTACAGGC 2700 CTTGCACCCC CTTTGCTGCT TCCCTCCTGC TCATTTGGGG CTGCCACCAG CTCTCCACCC 2760- TCCTGGTTCC GCTGGCCGGG CCAAGAGAGG ATGGAGGGAT GGGAGTCCCA GGAGATCCTT 2820 GTAAATAGTG GGGTGGGACT GTTCTGAGTG ATCACCCGAG CACTTAAAGC TCCAGAGTCC 2880 CATTCTTCCT GGATGGAGCA GGTGGAGGTG CAGAGGGGAT TTCCTCCTCT CCTTCCTCCT 2940 GTCGAGAATT AACACCTCTC CACAGCCTTC CCCTCCAGAA CACCAGCCAG GGAGGGGTGG 3000 GGAAGGAGGT CACAGCCAAG AAAACTGCCC TGTGACGACT TCCCTCCTTC CCGCCTATGT 3060 GAGCCATCCT GAGATGTCTG TACAATAGAA ACCAAACCAA ATGGGCACCC TCGGTTGCCG 3120 GGGGGCAGGT GGGGAGGGGG GTGGGAAGAA GGGATGTCTG TCTGTCGTCC CCCTCCCCCT 3180 CTCCACTCTT TACCCACAAA GGCAGAAGAC TGTTACACTA GGGGGCTCAG CAAATTCAAT 3240 CCCACCCTTA CCAATTGAGC CAAACCTAGA AACAAACACA AAACACGAAT AGTGAGAGAC 3300 AAAATAGAGG AGAGAAAGAG AGCATGAGAG GGAGCGAGAC AGGCGACCAA CACAGAGGAG 3360 AGAAAACAAA AATAGCAAAA AAAAAAAAAA AAAGCAGTTC TTTATAATTT AATATTCTAT 3420 TTTAATAAAG GCGTTTATTA CCATATAAAT GTAGCAAAGA ACCTGGGCTA ATATGAA

Seq ID NO: 12 Protein sequence Protein Accession #: XP_044166 1 11 21 31 41 51

FCFAMPS W SGIMERNGGF GE GCFGGSA KDRGL EDER ALQ ALDQLC GLGEPPAP 60

RAGEDGGGGG GGAPAQPTAP PQPAPPPPPA APPAAPTTAP AAQTPQPPTA PKGASDAKLC 120

ALYKEAELRL KGSSNTTECV PVPTSEHVAE IVGRQGCKIK ALRAKTNTYI KTPVRGEEPV 180

FMVTGRREDV ATARREIISA AEHFSMIRAS RNKSGAAFGV APALPGQVTI RVRVPYRWG 240 WGPKGATI KRIQQQTNTY IITPSRDRDP VFEITGAPGN VERAREEIET HIAVRTGKI 300

EYNNENDFLA GSPDAAIDSR YSDAWRVHQP GCKPLSTFRQ NSLGCIGECG VDSGFEAPR 360

GEQGGDFGYG GY FPGYGVG KQDVYYGVAE TSPPLWAGQE NATPTSVLFS SASSSSSSSA 420

KARAGPPGAH RSPATSAGPE AG PRRPPG EPLQGFSK G GGG RSPGGG RDCMVCFESE 480 VTAALVPCGH NLFCMECAVR ICERTDPECP VCHITATQAI RIFS

Seq ID NO: 13 DNA sequence Nucleic Acxd Accession tt: Eos sequence Coding sequence: 1..2982 1 11 21 31 41 51

I I I I I I

ATGGTTTTCT CTGTCAGGCA GTGTGGCCAT GTTGGCAGAA CTGAAGAAGT TTTACTGACG 60

TTCAAGATAT TCCTTGTCAT CATTTGTCTT CATGTCGTTC TGGTAACATC CCTGGAAGAA 120

GATACTGATA ATTCCAGTTT GTCACCACCA CCTGATGTTA CTTTAAGCTT ACTCCCTTCA 180 AACGAAACAG AAAAAACTAA AATCACTATA GTAAAAACCT TCAATGCTTC AGGCGTCAAA 240

CCCCAGAGAA ATATCTGCAA TTTGTCATCT ATTTGCAATG ACTCAGCATT TTTTAGAGGT 300

GAGATCATGT TTCAATATGA TAAAGAAAGC ACTGTTCCCC AGAATCAACA TATAACGAAT 360

GGCACCTTAA CTGGAGTCCT GTCTCTAAGT GAATTAAAAC GCTCAGAGCT CAACAAAACC 420

CTGCAAACCC TAAGTGAGAC TTACTTTATA ATGTGTGCTA CAGCAGAGGC CCAAAGCACA 480 TTAAATTGTA CATTCACAAT AAAACTGAAT AATACAATGA ATGCATGTGC TGTAATAGCT 540

GCTTTGGAAA GAGTAAAGAT TCGACCAATG GAACACTGCT GCTGTTCTGT CAGGATACCC 600

TGCCCTTCCT CCCCAGAAGA GTTGGAAAAG CTTCAGTGTG ACCTGCAGGA TCCCATTGTC 660

TGTCTTGCTG ACCATCCACG TGGCCCACCA TTTTCTTCCA GCCAATCCAT CCCAGTGGTG 720

CCTCGGGCCA CTGTGCTTTC CCAGGTCCCC AAAGCTACCT CTTTTGCTGA GCCTCCAGAT 780 TATTCACCTG TGACCCACAA TGTTCCCTCT CCAATAGGGG AGATTCAACC CCTTTCACCC 840

CAGCCTTCAG CTCCCATAGC TTCCAGCCCT GCCATTGACA TGCCCCCACA GTCTGAAACG 900

ATCTCTTCCC CTATGCCCCA AACCCATGTC TCCGGCACCC CACCTCCTGT GAAAGCCTCA 960

TTTTCCTCTC CCACCGTGTC TGCCCCTGCG AATGTCAACA CTACCAGCGC ACCTCCTGTC 1020

CAGACAGACA TCGTCAACAC CAGCAGTATT TCTGATCTTG AGAACCAAGT GTTGCAGATG 1080 GAGAAGGCTC TGTCCTTGGG CAGCCTGGAG CCTAACCTCG CAGGAGAAAT GATCAACCAA 1140

GTCAGCAGAC TCCTTCATTC CCCGCCTGAC ATGCTGGCCC CTCTGGCTCA AAGATTGCTG 1200

AAAGTAGTGG ATGACATTGG CCTACAGCTG AACTTTTCAA ACACGACTAT AAGTCTAACC 1260

TCCCCTTCTT TGGCTCTGGC TGTGATCAGA GTGAATGCCA GTAGTTTCAA CACAACTACC 1320

TTTGTGGCCC AAGACCCTGC AAATCTTCAG GTTTCTCTGG AAACCCAAGC TCCTGAGAAC 1380 AGTATTGGCA CAATTACTCT TCCTTCATCG CTGATGAATA ATTTACCAGC TCATGACATG 1440

GAGCTAGCTT CCAGGGTTCA GTTCAATTTT TTTGAAACAC CTGCTTTGTT TCAGGATCCT 1500

TCCCTGGAGA ACCTCTCTCT GATCAGCTAC GTCATATCAT CGAGTGTTGC AAACCTGACC 1560

GTCAGGAACT TGACAAGAAA CGTGACAGTC ACATTAAAGC ACATCAACCC GAGCCAGGAT 1620

GAGTTAACAG TGAGATGTGT ATTTTGGGAC TTGGGCAGAA ATGGTGGCAG AGGAGGCTGG 1680 TCAGACAATG GCTGCTCTGT CAAAGACAGG AGATTGAATG AAACCATCTG TACCTGTAGC 1740

CATCTAACAA GCTTCGGCGT TCTGCTGGAC CTATCTAGGA CATCTGTGCT GCCTGCTCAA 1800

ATGATGGCTC TGACGTTCAT TACATATATT GGTTGTGGGC TTTCATCAAT TTTTCTGTCA 1860

GTGACTCTTG TAACCTACAT AGCTTTTGAA AAGATCCGGA GGGATTACCC TTCCAAAATC 1920

CTCATCCAGC TGTGTGCTGC TCTGCTTCTG CTGAACCTGG TCTTCCTCCT GGACTCGTGG 1980 ATTGCTCTGT ATAAGATGCA AGGCCTCTGC ATCTCAGTGG CTGTATTTCT TCATTATTTT 2040

CTCTTGGTCT CATTCACATG GATGGGCCTA GAAGCATTCC ATATGTACCT GGCCCTTGTC 2100

AAAGTATTTA ATACTTACAT CCGAAAATAC ATCCTTAAAT TCTGCATTGT CGGTTGGGGG 2160

GTACCAGCTG TGGTTGTGAC CATCATCCTG ACTATATCCC CAGATAACTA TGGGCTTGGA 2220

TCCTATGGGA AATTCCCCAA TGGTTCACCG GATGACTTCT GCTGGATCAA CAACAATGCA 2280 GTATTCTACA TTACGGTGGT GGGATATTTC TGTGTGATAT TTTTGCTGAA CGTCAGCATG 2340

TTCATTGTGG TCCTGGTTCA GCTCTGTCGA ATTAAAAAGA AGAAGCAACT GGGAGCCCAG 2400

CGAAAAACCA GTATTCAAGA CCTCAGGAGT ATCGCTGGCC TTACATTTTT ACTGGGAATA 2460

ACTTGGGGCT TTGCCTTCTT TGCCTGGGGA CCAGTTAACG TGACCTTCAT GTATCTGTTT 2520

GCCATCTTTA ATACCTTACA AGGATTTTTC ATATTCATCT TTTACTGTGT GGCCAAAGAA 2580 AATGTCAGGA AGCAATGGAG GCGGTATCTT TGTTGTGGAA AGTTACGGCT GGCTGAAAAT 2640

TCTGACTGGA GTAAAACTGC TACTAATGGT TTAAAGAAGC AGACTGTAAA CCAAGGAGTG 2700

TCCAGCTCTT CAAATTCCTT ACAGTCAAGC AGTAACTCCA CTAACTCCAC CACACTGCTA 2760

GTGAATAATG ATTGCTCAGT ACACGCAAGC GGGAATGGAA ATGCTTCTAC AGAGAGGAAT 2820

GGGGTCTCTT TTAGTGTTCA GAATGGAGAT GTGTGCCTTC ACGATTTCAC TGGAAAACAG 2880 CACATGTTTA ACGAGAAGGA AGATTCCTGC AATGGGAAAG GCCGTATGGC TCTCAGAAGG 2940

ACTTCAAAGC GGGGAAGCTT ACACTTTATT GAGCAAATGT GA

Seq ID NO: 14 Protein sequence

Protein Accession #: Eos sequence

1 11 21 31 41 51

IVFSVRQCGH VIGRTEEVLLT FIKIF VIICL HIWLVTS EE DITDNSS SPP PIDVT SL PS 60

NETEKTKITI VKTFNASGVK PQRNICNLSS ICNDSAFFRG EIMFQYDKES TVPQNQHITN 120

GT TGVLS S E KRSELNKT LQTLSETYFI MCATAEAQST LNCTFTIKLN NTMNACAVIA 180 A ERVKIRPM EHCCCSVRIP CPSSPEE EK LQCDLQDPIV CLADHPRGPP FSSSQSIPW 240

PRATVLSQVP KATSFAEPPD YSPVTHNVPS PIGEIQPLSP QPSAPIASSP AIDMPPQSET 300

ISSPMPQTHV SGTPPPVKAS FSSPTVSAPA NVNTTSAPPV QTDIVNTSSI SD ENQV QM 360

EKALSLGS E PN AGEMINQ VSRLLHSPPD MLAPLAQRL KWDDIGLQL NFSNTTIS T 420

SPS ALAVIR VNASSFNTTT FVAQDPANLQ VS ETQAPEN SIGTIT PSS LMNNLPAHDM 480

ELASRVQFNF FETPA FQDP S ENLSLISY VISSSVAN T VRNLTRNVTV T KHINPSQD 540

E TVRCVFWD GRNGGRGGW SDNGCSVKDR R NETICTCS H TSFGVL D SRTSV PAQ 600

MMALTFITYI GCGLSSIF S VT VTYIAFE KIRRDYPSKI LIQLCAAL NL FL DSW 660

IALYKMQGLC ISVAVFLHYF LLVSFTWMG EAFHMYLALV KVFNTYIRKY I KFCIVGWG 720

VPAWVTII TISPDNYG G SYGKFPNGSP DDFCWINNNA VFYITWGYF CVIF NVSM 780

FIWLVQLCR IKKKKQLGAQ RKTSIQDLRS IAGITF LGI TWGFAFFAWG PVNVTFMY F 840

AIFNT QGFF IFIFYCVAKE NVRKQWRRYL CCGK RLAEN SDWSKTATNG KKQTVNQGV 900

SSSSNS QSS SNSTNSTTL VNNDCSVHAS GNGNASTERN GVSFSVQNGD VCLHDFTGKQ 960 HMFNEKEDSC NGKGRMA RR TSKRGS HFI EQM Seq ID NO: 15 DNA sequence Nucleic Acid Accession #: Eos sequence Coding sequence: 1..2904

1 11 21 31 41 51 _ .

I I I I I I

ATGGTTTTCT CTGTCAGGCA GTGTGGCCAT GTTGGCAGAA CTGAAGAAGT TTTACTGACG 60

TTCAAGATAT TCCTTGTCAT CATTTGTCTT CATGTCGTTC TGGTAACATC CCTGGAAGAA 120

GATACTGATA ATTCCAGTTT GTCACCACCA CCTGATGTTA CTTTAAGCTT ACTCCCTTCA 180

AACGAAACAG AAAAAACTAA AATCACTATA GTAAAAACCT TCAATGCTTC AGGCGTCAAA 240

CCCCAGΛGAA ATATCTGCAA TTTGTCATCT ATTTGCAATG ACTCAGCATT TTTTAGAGGT 300

GAGATCATGT TTCAATATGA TAAAGAAAGC ACTGTTCCCC AGAATCAACA TATAACGAAT 360

GGCACCTTAA CTGGAGTCCT GTCTCTAAGT GAATTAAACA CATTAAATTG TACATTCACA 420

ATAAAACTGA ATAATACAAT GAATGCATGT GCTGTAATAG CTGCTTTGGA AAGAGTAAAG 480

ATTCGACCAA TGGAACACTG CTGCTGTTCT GTCAGGATAC CCTGCCCTTC CTCCCCAGAA 540

GAGTTGGAAA AGCTTCAGTG TGACCTGCAG GATCCCATTG TCTGTCTTGC TGACCATCCA 600

CGTGGCCCAC CATTTTCTTC CAGCCAATCC ATCCCAGTGG TGCCTCGGGC CACTGTGCTT 660

TCCCAGGTCC CCAAAGCTAC CTCTTTTGCT GAGCCTCCAG ATTATTCACC TGTGACCCAC 720

AATGTTCCCT CTCCAATAGG GGAGATTCAA CCCCTTTCAC CCCAGCCTTC AGCTCCCATA 780

GCTTCCAGCC CTGCCATTGA CATGCCCCCA CAGTCTGAAA CGATCTCTTC CCCTATGCCC 840

CAAACCCATG TCTCCGGCAC CCCACCTCCT GTGAAAGCCT CATTTTCCTC TCCCACCGTG 900

TCTGCCCCTG CGAATGTCAA CACTACCAGC GCACCTCCTG TCCAGACAGA CATCGTCAAC 960

ACCAGCAGTA TTTCTGATCT TGAGAACCAA GTGTTGCAGA TGGAGAAGGC TCTGTCCTTG 1020

GGCAGCCTGG AGCCTAACCT CGCAGGAGAA ATGATCAACC AAGTCAGCAG ACTCCTTCAT 1080

TCCCCGCCTG ACATGCTGGC CCCTCTGGCT CAAAGATTGC TGAAAGTAGT GGATGACATT 1140

GGCCTACAGC TGAACTTTTC AAACACGACT ATAAGTCTAA CCTCCCCTTC TTTGGCTCTG 1200

GCTGTGATCA GAGTGAATGC CAGTAGTTTC AACACAACTA CCTTTGTGGC CCAAGACCCT 1260

GCAAATCTTC AGGTTTCTCT GGAAACCCAA GCTCCTGAGA ACAGTATTGG CACAATTACT 1320

CTTCCTTCAT CGCTGATGAA TAATTTACCA GCTCATGACA TGGAGCTAGC TTCCAGGGTT 1380

CAGTTCAATT TTTTTGAAAC ACCTGCTTTG TTTCAGGATC CTTCCCTGGA GAACCTCTCT 1440

CTGATCAGCT ACGTCATATC ATCGAGTGTT GCAAACCTGA CCGTCAGGAA CTTGACAAGA 1500

AACGTGACAG TCACATTAAA GCACATCAAC CCGAGCCAGG ATGAGTTAAC AGTGAGATGT 1560

GTATTTTGGG ACTTGGGCAG AAATGGTGGC AGAGGAGGCT GGTCAGACAA TGGCTGCTCT 1620

GTCAAAGACA GGAGATTGAA TGAAACCATC TGTACCTGTA GCCATCTAAC AAGCTTCGGC 1680

GTTCTGCTGG ACCTATCTAG GACATCTGTG CTGCCTGCTC AAATGATGGC TCTGACGTTC 1740

ATTACATATA TTGGTTGTGG GCTTTCATCA ATTTTTCTGT CAGTGACTCT TGTAACCTAC 1800

ATAGCTTTTG AAAAGATCCG GAGGGATTAC CCTTCCAAAA TCCTCATCCA GCTGTGTGCT 1860

GCTCTGCTTC TGCTGAACCT GGTCTTCCTC CTGGACTCGT GGATTGCTCT GTATAAGATG 1920

CAAGGCCTCT GCATCTCAGT GGCTGTATTT CTTCATTATT TTCTCTTGGT CTCATTCACA 1980

TGGATGGGCC TAGAAGCATT CCATATGTAC CTGGCCCTTG TCAAAGTATT TAATACTTAC 2040

ATCCGAAAAT ACATCCTTAA ATTCTGCATT GTCGGTTGGG GGGTACCAGC TGTGGTTGTG 2100

ACCATCATCC TGACTATATC CCCAGATAAC TATGGGCTTG GATCCTATGG GAAATTCCCC 2160

AATGGTTCAC CGGATGACTT CTGCTGGATC AACAACAATG CAGTATTCTA CATTACGGTG 2220

GTGGGATATT TCTGTGTGAT ATTTTTGCTG AACGTCAGCA TGTTCATTGT GGTCCTGGTT 2280

CAGCTCTGTC GAATTAAAAA GAAGAAGCAA CTGGGAGCCC AGCGAAAAAC CAGTATTCAA 2340

GACCTCAGGA GTATCGCTGG CCTTACATTT TTACTGGGAA TAACTTGGGG CTTTGCCTTC 2400

TTTGCCTGGG GACCAGTTAA CGTGACCTTC ATGTATCTGT TTGCCATCTT TAATACCTTA 2460

CAAGGATTTT TCATATTCAT CTTTTACTGT GTGGCCAAAG AAAATGTCAG GAAGCAATGG 2520

AGGCGGTATC TTTGTTGTGG AAAGTTACGG CTGGCTGAAA ATTCTGACTG GAGTAAAACT 2580

GCTACTAATG GTTTAAAGAA GCAGACTGTA AACCAAGGAG TGTCCAGCTC TTCAAATTCC 2640

TTACAGTCAA GCAGTAACTC CACTAACTCC ACCACACTGC TAGTGAATAA TGATTGCTCA 2700

GTACACGCAA GCGGGAATGG AAATGCTTCT ACAGAGAGGA ATGGGGTCTC TTTTAGTGTT 2760

CAGAATGGAG ATGTGTGCCT TCACGATTTC ACTGGAAAAC AGCACATGTT TAACGAGAAG 2820

GAAGATTCCT GCAATGGGAA AGGCCGTATG GCTCTCAGAA GGACTTCAAA GCGGGGAAGC 2880 TTACACTTTA TTGAGCAAAT GTGA Seq ID NO: 16 Protein sequence

Protein Accession #: Eos sequence

1 11 21 31 41 51

I I I I I I

MVFSVRQCGH VGRTEEVL T FKIFLVIICL, HWLVTS EE DTDNSS SPP PDVT SLLPS 60 NETEKTKITI VKTFNASGVK PQRNICNLSS ICNDSAFFRG EIMFQYDKES TVPQNQHITN 120

GTLTGVLS S E NTLNCTFT IKLNNTMNAC AVIAA ERVK IRPMEHCCCS VRIPCPSSPE 180

E EK QCD Q DPIVC ADHP RGPPFSSSQS IPWPRATV SQVPKATSFA EPPDYSPVTH 240

NVPSPIGEIQ P SPQPSAPI ASSPAIDMPP QSETISSPMP QTHVSGTPPP VKASFSSPTV 300

SAPANVNTTS APPVQTDIVN TSSISDLENQ V QMEKALSL GS EPNLAGE MINQVSRL H 360 SPPDMAPLA QRLLKWDDI GLQLNFSNTT IS TSPSLAL AVIRVNASSF NTTTFVAQDP 420

AN QVSLETQ APENSIGTIT LPSSLMNN P AHDMELASRV QFNFFETPA FODPSLEN S 480 ISYVISSSV ANLTVRNLTR NVTVT KHIN PSQDE TVRC VFWDLGRNGG RGG SDNGCS 540

VKDRRLNETI CTCSHLTSFG V LDLSRTSV LPAQMMALTF ITYIGCG SS IFLSVT VTY 600

IAFEKIRRDY PSKI IQLCA AL NLVFL DSWIALYKM QG CISVAVF LHYFLLVSFT 660 WMG EAFHMY LALVKVFNTY IRKYILKFCI VGWGVPAVW TIILTISPDN YG GSYGKFP 720

NGSPDDFCWI NNNAVFYITV VGYFCVIFLL NVSMFIWLV QLCRIKKKKQ LGAQRKTSIQ 780

DLRSIAGLTF L GIT GFAF FAWGPVNVTF MY FAIFNTL QGFFIFIFYC VAKENVRKQW 840

RRY CCGKLR AENSDWSKT ATNG KKQTV NQGVSSSSNS LQSSSNSTNS TTLL.VNNDCS 900

VHASGNGNAS TERNGVSFSV ONGDVCLHDF TGKQHMFNEK EDSCNGKGRM ALRRTSKRGS 960 HFIEQM

Seq ID NO: 17 DNA sequence

Nucleic Acid Accession #: Eos sequence

Coding sequence: 1..2811

1 11 21 31 41 51

I I I I I I

ATGGTTTTCT CTGTCAGGCA GTGTGGCCAT GTTGGCAGAA CTGAAGAAGT TTTACTGACG 60

TTCAAGATAT TCCTTGTCAT CATTTGTCTT CATGTCGTTC TGGTAACATC CCTGGAAGAA 120

GATACTGATA ATTCCAGTTT GTCACCACCA CCTGAGGTTG AAACAACAAG CCTCAATGAT 180

GTTACTTTAA GCTTACTCCC TTCAAACGAA ACAGGCGTCA AACCCCAGAG AAATATCTGC 240 AATTTGTCAT CTATTTGCAA TGACTCAGCA TTTTTTAGAG GTGAGATCAT GTTTCAATAT 300

GATAAAGAAA GCACTGTTCC CCAGAATCAA CATATAACGA ATGGCACCTT AACTGGAGTC 360

CTGTCTCTAA GTGAATTAAA ACGCTCAGAG CTCAACAAAA CCCTGCAAAC CCTAAGTGAG 420

ACTTACTTTA TAATGTGTGC TACAGCAGAG GCCCAAAGCA CATTAAATTG TACATTCACA 480

ATAAAACTGA ATAATACAAT GAATGCATGT GCTGTAATAG CTGCTTTGGA AAGAGTAAAG 540

ATTCGACCAA TGGAACACTG CTGCTGTTCT GTCAGGATAC CCTGCCCTTC CTCCCCAGAA 600

GAGTTGGAAA AGCTTCAGTG TGACCTGCAG GATCCCATTG TCTGTCTTGC TGACCATCCA 660

CGTGGCCCAC CATTTTCTTC CAGCCAATCC ATCCCAGTGG TGCCTCGGGC CACTGTGCTT 720

TCCCAGGTCC CCAAAGCTAC CTCTTTTGCT GAGCCTCCAG ATTATTCACC TGTGACCCAC 780

AATGTTCCCT CTCCAATAGG GGAGATTCAA CCCCTTTCAC CCCAGCCTTC AGCTCCCATA 840

GCTTCCAGCC CTGCCATTGA CATGCCCCCA CAGTCTGAAA CGATCTCTTC CCCTATGCCC 900

CAAACCCATG TCTCCGGCAC CCCACCTCCT GTGAAAGCCT CATTTTCCTC TCCCACCGTG 960

TCTGCCCCTG CGAATGTCAA CACTACCAGC GCACCTCCTG TCCAGACAGA CATCGTCAAC 1020

ACCAGCAGTA TTTCTGATCT TGAGAACCAA GTGTTGCAGA TGGAGAAGGC TCTGTCCTTG 1080

GGCAGCCTGG AGCCTAACCT CGCAGGAGAA ATGATCAACC AAGTCAGCAG ACTCCTTCAT 1140

TCCCCGCCTG ACATGCTGGC CCCTCTGGCT CAAAGATTGC TGAAAGTAGT GGATGACATT 1200

GGCCTACAGC TGAACTTTTC AAACACGACT ATAAGTCTAA CCTCCCCTTC TTTGGCTCTG 1260

GCTGTGATCA GAGTGAATGC CAGTAGTTTC AACACAACTA CCTTTGTGGC CCAAGACCCT 1320

GCAAATCTTC AGGTTTCTCT GGAAACCCAA GCTCCTGAGA ACAGTATTGG CACAATTACT 1380

CTTCCTTCAT CGCTGATGAA TAATTTACCA GCTCATGACA TGGAGCTAGC TTCCAGGGTT 1440

CAGTTCAATT TTTTTGAAAC ACCTGCTTTG TTTCAGGATC CTTCCCTGGA GAACCTCTCT 1500

CTGATCAGCT ACGTCATATC ATCGAGTGTT GCAAACCTGA CCGTCAGGAA CTTGACAAGA 1560

AACGTGACAG TCACATTAAA GCACATCAAC CCGAGCCAGG ATGAGTTAAC AGTGAGATGT 1620

GTATTTTGGG ACTTGGGCAG AAATGGTGGC AGAGGAGGCT GGTCAGACAA TGGCTGCTCT 1680

GTCAAAGACA GGAGATTGAA TGAAACCATC TGTACCTGTA GCCATCTAAC AAGCTTCGGC 1740

GTTCTGCTGG ACCTATCTAG GACATCTGTG CTGCCTGCTC AAATGATGGC TCTGACGTTC 1800

ATTACATATA TTGGTTGTGG GCTTTCATCA ATTTTTCTGT CAGTGACTCT TGTAACCTAC 1860

ATAGCTTTTG AAAAGATCCG GAGGGATTAC CCTTCCAAAA TCCTCATCCA GCTGTGTGCT 1920

GCTCTGCTTC TGCTGAACCT GGTCTTCCTC CTGGACTCGT GGATTGCTCT GTATAAGATG 1980

CAAGGCCTCT GCATCTCAGT GGCTGTATTT CTTCATTATT TTCTCTTGGT CTCATTCACA 2040

TGGATGGGCC TAGAAGCATT CCATATGTAC CTGGCCCTTG TCAAAGTATT TAATACTTAC 2100

ATCCGAAAAT ACATCCTTAA ATTCTGCATT GTCGGTTGGG GGGTACCAGC TGTGGTTGTG 2160

ACCATCATCC TGACTATATC CCCAGATAAC TATGGGCTTG GATCCTATGG GAAATTCCCC 2220

AATGGTTCAC CGGATGACTT CTGCTGGATC AACAACAATG CAGTATTCTA CATTACGGTG 2280

GTGGGATATT TCTGTGTGAT ATTTTTGCTG AACGTCAGCA TGTTCATTGT GGTCCTGGTT 2340

CAGCTCTGTC GAATTAAAAA GAAGAAGCAA CTGGGAGCCC AGCGAAAAAC CAGTATTCAA 2400

GACCTCAGGA GTATCGCTGG CCTTACATTT TTACTGGGAA TAACTTGGGG CTTTGCCTTC 2460

TTTGCCTGGG GACCAGTTAA CGTGACCTTC ATGTATCTGT TTGCCATCTT TAATACCTTA 2520

CAAGGATTTT TCATATTCAT CTTTTACTGT GTGGCCAAAG AAAATGTCAG GAAGCAATGG 2580

AGGCGGTATC TTTGTTGTGG AAAGTTACGG CTGGCTGAAA ATTCTGGAAA TGCTTCTACA 2640

GAGAGGAATG GGGTCTCTTT TAGTGTTCAG AATGGAGATG TGTGCCTTCA CGATTTCACT 2700

GGAAAACAGC ACATGTTTAA CGAGAAGGAA GATTCCTGCA ATGGGAAAGG CCGTATGGCT 2760

CTCAGAAGGA CTTCAAAGCG GGGAAGCTTA CACTTTATTG AGCAAATGTG A

Seq ID NO: 18 Protein sequence Protein Accession #: Eos sequence 1 11 21 31

MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HWLVTSLEE DTDNSSLSPP PEVETTSLND 60

VT S LPSNE TGVKPQRNIC N SSICNDSA FFRGEIMFQY DKESTVPQNQ HITNGTLTGV 120 S SE KRSE LNKTLQTLSE TYFIMCATAE AQSTLNCTFT IKLNNTMNAC AVIAALERVK 180

IRPMEHCCCS VRIPCPSSPE ELEKLQCDLQ DPIVCLADHP RGPPFSSSQS IPWPRATVL 240

SQVPKATSFA EPPDYSPVTH NVPSPIGEIQ PLSPQPSAPI ASSPAIDMPP QSETISSPMP 300

QTHVSGTPPP VKASFSSPTV SAPANVNTTS APPVQTDIVN TSSISDLENQ VLQMEKALSL 360

GSLEPN AGE MINQVSRLLH SPPDMLAPLA QRLLKWDDI GLQLNFSNTT ISLTSPSLAL 420

AVIRVNASSF NTTTFVAQDP ANLQVSLETQ APENSIGTIT LPSSLMNNLP AHDMELASRV 480

QFNFFETPA FQDPSLENLS LISYVISSSV ANLTVRNLTR NVTVTLKHIN PSQDELTVRC 540

VFWD GRNGG RGGWSDNGCS VKDRRLNETI CTCSHLTSFG VLLDLSRTSV LPAQMMALTF 600

ITYIGCG SS IFLSVTLVTY IAFEKIRRDY PSKILIQLCA ALLLLNLVFL LDSWIALYKM 660

QGLCISVAVF LHYFLLVSFT WMGLEAFHMY LALVKVFNTY IRKYILKFCI VGWGVPA W 720

TIILTISPDN YGLGSYGKFP NGSPDDFCWI NNNAVFYITV VGYFCVIFLL NVSMFIWLV 780

QLCRIKKKKQ LGAQRKTSIQ DLRSIAGLTF LLGITWGFAF FA GPVNVTF MYLFAIFNTL 840

QGFFIFIFYC VAKENVRKQW RRYLCCGKLR LAENSGNAST ERNGVSFSVQ NGDVCLHDFT 900

GKQHMFNEKE DSCNGKGRMA LRRTSKRGSL HFIEQM

Seq ID NO: 19 DNA sequence

Nucleic Acid Accession #: Eos sequence

Coding sequence: 1..3045

1 11 21 31

I I I I 1

ATGGTTTTCT CTGTCAGGCA GTGTGGCCAT GTTGGCAGAA 1

CTGAAGAAGT TTTACTGACG 60 TTCAAGATAT TCCTTGTCAT CATTTGTCTT CATGTCGTTC TGGTAACATC CCTGGAAGAA 120 GATACTGATA ATTCCAGTTT GTCACCACCA CCTGCTAAAT TATCTGTTGT CAGTTTTGCC 180 CCCTCCTCCA ATGAGGTTGA AACAACAAGC CTCAATGATG TTACTTTAAG CTTACTCCCT 240 TCAAACGAAA CAGAAAAAAC TAAAATCACT ATAGTAAAAA CCTTCAATGC TTCAGGCGTC 300 AAACCCCAGA GAAATATCTG CAATTTGTCA TCTATTTGCA ATGACTCAGC ATTTTTTAGA 360 GGTGAGATCA TGTTTCAATA TGATAAAGAA AGCACTGTTC CCCAGAATCA ACATATAACG 420 AATGGCACCT TAACTGGAGT CCTGTCTCTA AGTGAATTAA AACGCTCAGA GCTCAACAAA 480 ACCCTGCAAA CCCTAAGTGA GACTTACTTT ATAATGTGTG CTACAGCAGA GGCCCAAAGC 540 ACATTAAATT GTACATTCAC AATAAAACTG AATAATACAA TGAATGCATG TGCTGCAATA 600 GCCGCTTTGG AAAGAGTAAA GATTCGACCA ATGGAACACT GCTGCTGTTC TGTCAGGATA 660 CCCTGCCCTT CCTCCCCAGA AGAGTTGGGA AAGCTTCAGT GTGACCTGCA GGATCCCATT 720 GTCTGTCTTG CTGACCATCC ACGTGGCCCA CCATTTTCTT CCAGCCAATC CATCCCAGTG 780 GTGCCTCGGG CCACTGTGCT TTCCCAGGTC CCCAAAGCTA CCTCTTTTGC TGAGCCTCCA 840 GATTATTCAC CTGTGACCCA CAATGTTCCC TCTCCAATAG GGGAGATTCA ACCCCTTTCA 900 CCCCAGCCTT CAGCTCCCAT AGCTTCCAGC CCTGCCATTG ACATGCCCCC ACAGTCTGAA 960

ACGATCTCTT CCCCTATGCC CCAAACCCAT GTCTCCGGCA CCCCACCTCC TGTGAAAGCC 1020

TCATTTTCCT CTCCCACCGT GTCTGCCCCT GCGAATGTCA ACACTACCAG CGCACCTCCT 1080

GTCCAGACAG ACATCGTCAA CACCAGCAGT ATTTCTGATC TTGAGAACCA AGTGTTGCAG 1140

5 ATGGAGAAGG CTCTGTCCTT GGGCAGCCTG GAGCCTAACC TCGCAGGAGA AATGATCAAC 1200

CAAGTCAGCA GACTCCTTCA TTCCCCGCCT GACATGCTGG CCCCTCTGGC TCAAAGATTG 1260

CTGAAAGTAG TGGATGACAT TGGCCTACAG CTGAACTTTT CAAACACGAC TATAAGTCTA 1320

ACCTCCCCTT CTTTGGCTCT GGCTGTGATC AGAGTGAATG CCAGTAGTTT CAACACAACT 1380

ACCTTTGTGG CCCAAGACCC TGCAAATCTT CAGGTTTCTC TGGAAACCCA AGCTCCTGAG 1440

10 AACAGTATTG GCACAATTAC TCTTCCTTCA TCGCTGATGA ATAATTTACC AGCTCATGAC 1500

ATGGAGCTAG CTTCCAGGGT TCAGTTCAAT TTTTTTGAAA CACCTGCTTT GTTTCAGGAT 1560

CCTTCCCTGG AGAACCTCTC TCTGATCAGC TACGTCATAT CATCGAGTGT TGCAAACCTG 1620

ACCGTCAGGA ACTTGACAAG AAACGTGACA GTCACATTAA AGCACATCAA CCCGAGCCAG 1680

GATGAGTTAA CAGTGAGATG TGTATTTTGG GACTTGGGCA GAAATGGTGG CAGAGGAGGC 1740

15 TGGTCAGACA ATGGCTGCTC TGTCAAAGAC AGGAGATTGA ATGAAACCAT CTGTACCTGT 1800

AGCCATCTAA CAAGCTTCGG CGTTCTGCTG GACCTATCTA GGACATCTGT GCTGCCTGCT 1860

CAAATGATGG CTCTGACGTT CATTACATAT ATTGGTTGTG GGCTTTCATC AATTTTTCTG 1920

TCAGTGACTC TTGTAACCTA CATAGCTTTT GAAAAGATCC GGAGGGATTA CCCTTCCAAA 1980

ATCCTCATCC AGCTGTGTGC TGCTCTGCTT CTGCTGAACC TGGTCTTCCT CCTGGACTCG 2040

20 TGGATTGCTC TGTATAAGAT GCAAGGCCTC TGCATCTCAG TGGCTGTATT TCTTCATTAT 2100

TTTCTCTTGG TCTCATTCAC ATGGATGGGC CTAGAAGCAT TCCATATGTA CCTGGCCCTT 2160

GTCAAAGTAT TTAATACTTA CATCCGAAAA TACATCCTTA AATTCTGCAT TGTCGGTTGG 2220

GGGGTACCAG CTGTGGTTGT GACCATCATC CTGACTATAT CCCCAGATAA CTATGGGCTT 2280

GGATCCTATG GGAAATTCCC CAATGGTTCA CCGGATGACT TCTGCTGGAT CAACAACAAT 2340

25 GCAGTATTCT ACATTACGGT GGTGGGATAT TTCTGTGTGA TATTTTTGCT GAACGTCAGC 2400

ATGTTCATTG TGGTCCTGGT TCAGCTCTGT CGAATTAAAA AGAAGAAGCA ACTGGGAGCC 2460

CAGCGAAAAA CCAGTATTCA AGACCTCAGG AGTATCGCTG GCCTTACATT TTTACTGGGA 2520

ATAACTTGGG GCTTTGCCTT CTTTGCCTGG GGACCAGTTA ACGTGACCTT CATGTATCTG 2580

TTTGCCATCT TTAATACCTT ACAAGGATTT TTCATATTCA TCTTTTACTG TGTGGCCAAA 2640

30 GAAAATGTCA GGAAGCAATG GAGGCGGTAT CTTTGTTGTG GAAAGTTACG GCTGGCTGAA 2700

AATTCTGACT GGAGTAAAAC TGCTACTAAT GGTTTAAAGA AGCAGACTGT AAACCAAGGA 2760

GTGTCCAGCT CTTCAAATTC CTTACAGTCA AGCAGTAACT CCACTAACTC CACCACACTG 2820

CTAGTGAATA ATGATTGCTC AGTACACGCA AGCGGGAATG GAAATGCTTC TACAGAGAGG 2880

AATGGGGTCT CTTTTAGTGT TCAGAATGGA GATGTGTGCC TTCACGATTT CACTGGAAAA 2940

35 CAGCACATGT TTAACGAGAA GGAAGATTCC TGCAATGGGA AAGGCCGTAT GGCTCTCAGA 3000

AGGACTTCAA AGCGGGGAAG CTTACACTTT ATTGAGCAAA TGTGA

Seq ID NO: 20 Protein sequence:

Protein Accession #: Eos sequence

40 1 11 21 31 41 51

I I I I I I

MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HWLVTSLEE DTDNSSLSPP PAKLSWSFA 60

PSSNEVETTS LNDVTLSLLP SNETEKTKIT IVKTFNASGV KPQRNICNLS SICNDSAFFR 120

GEIMFQYDKE STVPQNQHIT NGTLTGVLSL SELKRSELNK TLQTLSETYF IMCATAEAQS 180

45 TLNCTFTIKL NNTMNACAAI AALERVKIRP MEHCCCSVRI PCPSSPEELG KLQCDLQDPI 240

VCLADHPRGP PFSSSQSIPV VPRATVLSQV PKATSFAEPP DYSPVTHNVP SPIGEIQPLS 300

PQPSAPIASS PAIDMPPQSE TISSPMPQTH VSGTPPPVKA SFSSPTVSAP ANVNTTSAPP 360

VQTDIVNTSS ISDLENQVLQ MEKALSLGSL EPNLAGEMIN QVSRLLHSPP DMLAPLAQRL 420

LKWDDIGLQ LNFSNTTISL TSPSLALAVI RVNASSFNTT TFVAQDPANL QVSLETQAPE 480

50 NSIGTITLPS SLMNNLPAHD MELASRVQFN FFETPALFQD PSLENLSLIS YVIΞSSVANL 540

TVRNLTRNVT VTLKHINPSQ DELTVRCVFW DLGRNGGRGG WSDNGCSVKD RRLNETICTC 600

SHLTSFGVLL DLSRTSVLPA QMMALTFITY IGCGLSSIFL SVTLVTYIAF EKIRRDYPSK 660

ILIQLCAALL LLNLVFLLDS WIALYKMQGL CISVAVFLHY FLLVSFT MG LEAFHMYLAL 720

VKVFNTYIRK YILKFCIVG GVPAVWTII LTISPDNYGL GSYGKFPNGS PDDFC INNN 780

55 AVFYITWGY FCVIFLLNVS MFIWLVQLC RIKKKKQLGA QRKTSIQDLR SIAGLTFLLG 840

ITWGFAFFAW GPVNVTFMYL FAIFNTLQGF FIFIFYCVAK ENVRKQ RRY LCCGKLRLAE 900

NSDWSKTATN GLKKQTVNQG VSSSSNSLQS SSNSTNSTTL LVNNDCSVHA SGNGNASTER 960 NGVSFSVQNG DVCLHDFTGK QHMFNEKEDS CNGKGRMALR RTSKRGSLHF IEQM

60 Seq ID NO: 21 DNA sequence

Nucleic Acid Accession #: NM_005756.1

Coding sequence: 37..3117

1 11 21 31 41 51

O «D A'GCCAGCCCG A IGGACGCGAG C'GGCAGGTGT G ICACAGAGGT T'CTCCACTTT G ITTTTCTGAA 60

CTCGCGGTCA GGATGGTTTT CTCTGTCAGG CAGTGTGGCC ATGTTGGCAG AACTGAAGAA 120

GTTTTACTGA CGTTCAAGAT ATTCCTTGTC ATCATTTGTC TTCATGTCGT TCTGGTAACA 180

TCCCTGGAAG AAGATACTGA TAATTCCAGT TTGTCACCAC CACCTGCTAA ATTATCTGTT 240

GTCAGTTTTG CCCCCTCCTC CAATGAGGTT GAAACAACAA GCCTCAATGA TGTTACTTTA 300

70 AGCTTACTCC CTTCAAACGA AACAGAAAAA ACTAAAATCA CTATAGTAAA AACCTTCAAT 360

GCTTCAGGCG TCAAACCCCA GAGAAATATC TGCAATTTGT CATCTATTTG CAATGACTCA 420

GCATTTTTTA GAGGTGAGAT CATGTTTCAA TATGATAAAG AAAGCACTGT TCCCCAGAAT 480

CAACATATAA CGAATGGCAC CTTAACTGGA GTCCTGTCTC TAAGTGAATT AAAACGCTCA 540

GAGCTCAACA AAACCCTGCA AACCCTAAGT GAGACTTACT TTATAATGTG TGCTACAGCA 600

75 GAGGCCCAAA GCACATTAAA TTGTACATTC ACAATAAAAC TGAATAATAC AATGAATGCA 660

TGTGCTGCAA TAGCCGCTTT GGAAAGAGTA AAGATTCGAC CAATGGAACA CTGCTGCTGT 720

TCTGTCAGGA TACCCTGCCC TTCCTCCCCA GAAGAGTTGG GAAAGCTTCA GTGTGACCTG 780

CAGGATCCCA TTGTCTGTCT TGCTGACCAT CCACGTGGCC CACCATTTTC TTCCAGCCAA 840

TCCATCCCAG TGGTGCCTCG GGCCACTGTG CTTTCCCAGG TCCCCAAAGC TACCTCTTTT 900

80 GCTGAGCCTC CAGATTATTC ACCTGTGACC CACAATGTTC CCTCTCCAAT AGGGGAGATT 960

CAACCCCTTT CACCCCAGCC TTCAGCTCCC ATAGCTTCCA GCCCTGCCAT TGACATGCCC 1020

CCACAGTCTG AAACGATCTC TTCCCCTATG CCCCAAACCC ATGTCTCCGG CACCCCACCT 1080

CCTGTGAAAG CCTCATTTTC CTCTCCCACC GTGTCTGCCC CTGCGAATGT CAACACTACC 1140

AGCGCACCTC CTGTCCAGAC AGACATCGTC AACACCAGCA GTATTTCTGA TCTTGAGAAC 1200

85 CAAGTGTTGC AGATGGAGAA GGCTCTGTCC TTGGGCAGCC TGGAGCCTAA CCTCGCAGGA 1260 GAAATGATCA ACCAAGTCAG CAGACTCCTT CATTCCCCGC CTGACATGCT GGCCCCTCTG 1320 GCTCAAAGAT TGCTGAAAGT AGTGGATGAC ATTGGCCTAC AGCTGAACTT TTCAAACACG 1380 ACTATAAGTC TAACCTCCCC TTCTTTGGCT CTGGCTGTGA TCAGAGTGAA TGCCAGTAGT 1440 TTCAACACAA CTACCTTTGT GGCCCAAGAC CCTGCAAATC TTCAGGTTTC TCTGGAAACC 1500 CAAGCTCCTG AGAACAGTAT TGGCACAATT ACTCTTCCTT CATCGCTGAT GAATAATTTA 1560 CCAGCTCATG ACATGGAGCT AGCTTCCAGG GTTCAGTTCA ATTTTTTTGA AACACCTGCT 1620 TTGTTTCAGG ATCCTTCCCT GGAGAACCTC TCTCTGATCA GCTACGTCAT ATCATCGAGT 1680 GTTGCAAACC TGACCGTCAG GAACTTGACA AGAAACGTGA CAGTCACATT AAAGCACATC 1740 AACCCGAGCC AGGATGAGTT AACAGTGAGA TGTGTATTTT GGGACTTGGG CAGAAATGGT 1800 GGCAGAGGAG GCTGGTCAGA CAATGGCTGC TCTGTCAAAG ACAGGAGATT GAATGAAACC 1860 ATCTGTACCT GTAGCCATCT AACAAGCTTC GGCGTTCTGC TGGACCTATC TAGGACATCT 1920 GTGCTGCCTG CTCAAATGAT GGCTCTGACG TTCATTACAT ATATTGGTTG TGGGCTTTCA 1980 TCAATTTTTC TGTCAGTGAC TCTTGTAACC TACATAGCTT TTGAAAAGAT CCGGAGGGAT 2040 TACCCTTCCA AAATCCTCAT CCAGCTGTGT GCTGCTCTGC TTCTGCTGAA CCTGGTCTTC 2100 CTCCTGGACT CGTGGATTGC TCTGTATAAG ATGCAAGGCC TCTGCATCTC AGTGGCTGTA 2160 TTTCTTCATT ATTTTCTCTT GGTCTCATTC ACATGGATGG GCCTAGAAGC ATTCCATATG 2220 TACCTGGCCC TTGTCAAAGT ATTTAATACT TACATCCGAA AATACATCCT TAAATTCTGC 2280 ATTGTCGGTT GGGGGGTACC AGCTGTGGTT GTGACCATCA TCCTGACTAT ATCCCCAGAT 2340 .AACTATGGGC TTGGATCCTA TGGGAAATTC CCCAATGGTT CACCGGATGA CTTCTGCTGG 2400 ATCAACAACA ATGCAGTATT CTACATTACG GTGGTGGGAT ATTTCTGTGT GATATTTTTG 2460 CTGAACGTCA GCATGTTCAT TGTGGTCCTG GTTCAGCTCT GTCGAATTAA AAAGAAGAAG 2520 CAACTGGGAG CCCAGCGAAA AACCAGTATT CAAGACCTCA GGAGTATCGC TGGCCTTACA 2580 TTTTTACTGG GAATAACTTG GGGCTTTGCC TTCTTTGCCT GGGGACCAGT TAACGTGACC 2640 TTCATGTATC TGTTTGCCAT CTTTAATACC TTACAAGGAT TTTTCATATT CATCTTTTAC 2700 TGTGTGGCCA AAGAAAATGT CAGGAAGCAA TGGAGGCGGT ATCTTTGTTG TGGAAAGTTA 2760 CGGCTGGCTG AAAATTCTGA CTGGAGTAAA ACTGCTACTA ATGGTTTAAA GAAGCAGACT 2820 GTAAACCAAG GAGTGTCCAG CTCTTCAAAT TCCTTACAGT CAAGCAGTAA CTCCACTAAC 2880 TCCACCACAC TGCTAGTGAA TAATGATTGC TCAGTACACG CAAGCGGGAA TGGAAATGCT 2940 TCTACAGAGA GGAATGGGGT CTCTTTTAGT GTTCAGAATG GAGATGTGTG CCTTCACGAT 3000 TTCACTGGAA AACAGCACAT GTTTAACGAG AAGGAAGATT CCTGCAATGG GAAAGGCCGT 3060 ATGGCTCTCA GAAGGACTTC AAAGCGGGGA AGCTTACACT TTATTGAGCA AATGTGATTC 3120 CTTTCTTCTA AAATCAAAGC ATGATGCTTG ACAGTGTGAA ATGTCCAATT TTACCTTTTA 3180 CACAATGTGA GATGTATGAA AATCAACTCA TTTTATTCTC GGCAACATCT GGAGAAGCAT 3240 AAGCTAATTA AGGGCGATGA TTATTATTAC AAGAAGAAAC CAAGACATTA CACCATGGTT 3300 TTTAGACATT TCTGATTTGG TTTCTTATCT TTCATTTTAT AAGAAGGTTG GTTTTAAACA 3360 ATACACTAAG AATGACTCCT ATAAAGAAAA CAAAAAAAGG TAGTGAACTT TCAGCTACCT 3420 TTTAAAGAGG CTAAGTTATC TTTGATAACA TCATATAAAG CAACTGTTGA CTTCAGCCTG 3480 TTGGTGAGTT TAGTTGTGCA TGCCTTTGTT GTATATAAGC TAAATTCTAG TGACCCATGT 3540 GTCAAAAATC TTACTTCTAC ATTTTTTTGT ATTTATTTTC TACTGTGTAA ATGTATTCCT 3600 TTGTAGAATC ATGGTTGTTT TGTCTCACGT GATAATTCAG AAAATCCTTG CTCGTTCCGC 3660 AAATCCTAAA GCTCCTTTTG GAGATGATAT AGGATGTGAA ATACAGAAAC CTCAGTGAAA 3720 TCAAGAAATA ATGATCCCAG CCAGACTGAG AAAATGTAAG CAGACAGTGC CACAGTTAGC 3780 TCATACAGTG CCTTTGAGCA AGTTAGGAAA AGATGCCCCC ACTGGGCAGA CACAGCCCTA 3840 TGGGTCATGG TTTGACAAAC AGAGTGAGAG ACCATATTTT AGCCCCACTC ACCCTCTTGG 3900 GTGCACGACC TGTACAGCCA AACACAGCAT CCAATATGAA TACCCATCCC CTGACCGCAT 3960 CCCCAGTAGT CAGATTATAG AATCTGCACC AAGATGTTTA GCTTTATACC TTGGCCACAG 4020 AGAGGGATGA ACTGTCATCC AGACCATGTG TCAGGAAAAT TGTGAACGTA GATGAGGTAC 4080 ATACACTGCC GCTTCTCAAA TCCCCAGAGC CTTTAGGAAC AGGAGAGTAG ACTAGGATTC 4140 CTTCTCTTAA AAAGGTACAT ATATATGGAA AAAAATCATA TTGCCGTTCT TTAAAAGGCA 4200 ACTGCATGGT ACATTGTTGA TTGTTATGAC TGGTACACTC TGGCCCAGCC AGAGCTATAA 4260 TTGTTTTTTA AATGTGTCTT GAAGAATGCA CAGTGACAAG GGGAGTAGCT ATTGGGAACA 4320 GGGAACTGTC CTACACTGCT ATTGTTGCTA CATGTATCGA GCCTTGATTG CTCCTAGTTA 4380 TATACAGGGT CTATCTTGCT TCCTACCTAC ATCTGCTTGA GCAGTGCCTC AAGTACATCC 4440 TTATTAGGAA CATTTCAAAC CCCTTTTAGT TAAGTCTTTC ACTAAGGTTC TCTTGCATAT 4500 ATTTCAAGTG AATGTTGGAT CTCAGACTAA CCATAGTAAT AATACACATT TCTGTGAGTG 4560 CTGACTTGTC TTTGCAATAT TTCTTTTCTG ATTTATTTAA TTTTCTTGTA TTTATATGTT 4620 AAAATCAAAA ATGTTAAAAT CAATGAAATA AATTTGCAGT TAAGA

Seq ID NO: 22 Protein sequence

Protein Accession #: NP_005747.1

1 11 21 31 41 51

M rVFSVRQCGH V iGRTEEVLLT F iKIFLVIICL H iWLVTSLEE D iTDNSSLSPP P iAKLSWSFA 60

PSSNEVETTS LNDVTLSLLP SNETGVKPQR NICNLSSICN DSAFFRGEIM FQYDKESTVP 120

QNQHITNGTL TGVLSLSELK RSELNKTLQT LSETYFIMCA TAEAQSTLNC TFTIKLNNTM 180

NACAVIAALE RVKIRPMEHC CCSVRIPCPS SPEELEKLQC DLQDPIVCLA DHPRGPPFSS 240

SQSIPWPRA TVLSQVPKAT SFAEPPDYSP VTHNVPSPIG EIQPLSPQPS APIASSPAID 300

MPPQSETISS PMPQTHVSGT PPPVKASFSS PTVSAPANVN TTSAPPVQTD IVNTSSISDL 360

ENQVLQMEKA LSLGSLEPNL AGEMINQVSR LLHSPPDMLA PLAQRLLKW DDIGLQLNFS 420

NTTISLTSPS LALAVIRVNA SSFNTTTFVA QDPANLQVSL ETQAPENSIG TITLPSSLMN 480

NLPAHDMELA SRVQFNFFET PALFQDPSLE NLSLISYVIS SSVANLTVRN LTRNVTVTLK 540

HINPSQDELT VRCVFWDLGR NGGRGGWSDN GCSVKDRRLN ETICTCSHLT SFGVLLDLSR 600

TSVLPAQMMA LTFITYIGCG LSSIFLSVTL VTYIAFEKIR RDYPSKILIQ LCAALLLLNL 660

VFLLDSWIAL YKMQGLCISV AVFLHYFLLV SFTWMGLEAF HMYLALVKVF NTYIRKYILK 720

FCIVGWGVPA VWTIILTIS PDNYGLGSYG KFPNGSPDDF CWINNNAVFY ITWGYFCVI 780

FLLNVSMFIV VLVQLCRIKK KKQLGAQRKT SIQDLRSIAG LTFLLGITWG FAFFAWGPVN 840

VTFMYLFAIF NTLQGFFIFI FYCVAKENVR KQWRRYLCCG KLRLAENSDW SKTATNGLKK 900

QTVNQGVSSS SNSLQSSSNS TNSTTLLVNN DCSVHASGNG NASTERNGVS FSVQNGDVCL 960 HDFTGKQHMF NEKEDSCNGK GRMALRRTSK RGSLHFIEQM

Seq ID NO: 23 DNA sequence

Nucleic Acid Accession #: NM_001565.1

Coding sequence: 67..363

1 11 21 31 41

I I I I GAGACATTCC TCAATTGCTT AGACATATTC TGAGCCTACA GCAGAGGAAC CTCCAGTCTC 60

AGCACCATGA ATCAAACTGC GATTCTGATT TGCTGCCTTA TCTTTCTGAC TCTAAGTGGC 120

ATTCAAGGAG TACCTCTCTC TAGAACCGTA CGCTGTACCT GCATCAGCAT TAGTAATCAA 180

CCTGTTAATC CAAGGTCTTT AGAAAAACTT GAAATTATTC CTGCAAGCCA ATTTTGTCCA 240

5 CGTGTTGAGA TCATTGCTAC AATGAAAAAG AAGGGTGAGA AGAGATGTCT GAATCCAGAA 300

TCGAAGGCCA TCAAGAATTT ACTGAAAGCA GTTAGCAAGG AAATGTCTAA AAGATCTCCT 360

TAAAACCAGA GGGGAGCAAA ATCGATGCAG TGCTTCCAAG GATGGACCAC ACAGAGGCTG 420

CCTCTCCCAT CACTTCCCTA CATGGAGTAT ATGTCAAGCC ATAATTGTTC TTAGTTTGCA 480

GTTACACTAA AAGGTGACCA ATGATGGTCA CCAAATCAGC TGCTACTACT CCTGTAGOAA 540

10 GGTTAATGTT CATCATCCTA AGCTATTCAG TAATAACTCT ACCCTGGCAC TATAATGTAA 600

GCTCTACTGA GGTGCTATGT TCTTAGTGGA TGTTCTGACC CTGCTTCAAA TATTTCCCTC 660

ACCTTTCCCA TCTTCCAAGG GTACTAAGGA ATCTTTCTGC TTTGGGGTTT ATCAGAATTC 720

TCAGAATCTC AAATAACTAA AAGGTATGCA ATCAAATCTG CTTTTTAAAG AATGCTCTTT 780

ACTTCATGGA CTTCCACTGC CATCCTCCCA AGGGGCCCAA ATTCTTTCAG TGGCTACCTA 840

15 CATACAATTC CAAACACATA CAGGAAGGTA GAAATATCTG AAAATGTATG TGTAAGTATT 900

CTTATTTAAT GAAAGACTGT ACAAAGTATA AGTCTTAGAT GTATATATTT CCTATATTGT 960

TTTCAGTGTA CATGGAATAA CATGTAATTA AGTACTATGT ATCAATGAGT AACAGGAAAA 1020

TTTTAAAAAT ACAGATAGAT ATATGCTCTG CATGTTACAT AAGATAAATG TGCTGAATGG 1080 TTTTCAAATA AAAATGAGGT ACTCTCCTGG AAATATTAAG

20

Seq ID NO: 24 Protein sequence

Protein Accession #: NP_001556.1

1 11 21 31 41 51 I I I I I I

ZD MNQTAILICC LIFLTLSGIQ GVPLSRTVRC TCISISNQPV NPRSLEKLEI IPASQFCPRV 60 EIIATMKKKG EKRCLNPESK AIKNLLKAVS KEMSKRSP

Seq ID NO: 25 DNA sequence Nucleic Acid Accession #: XM_030559 J\) Coding sequence: 1..1119

1 11 21 31 41 SI

ATGAACCGCA GCCACCGGCA CGGGGCGGGC AGCGGCTGCC TGGGCACTAT GGAGGTGAAG 60

AGCAAGTTTG GAGCTGAATT TCGTCGGTTT TCGCTGGAAA GATCAAAACC TGGAAAATTT 120

35 GAGGAGTTTT ATGGATTACT ACAACATGTT CATAAGATCC CCAATGTTGA CGTTTTGGTA 180

GGCTATGCAG ACATCCATGG AGACTTACTA CCTATAAATA ATGATGATAA TTATCACAAA 240

GCTGTTTCAA CGGCCAATCC ACTGCTTAGG ATATTTATAC AAAAGAAGGA AGAAGCAGAC 300

TACAGTGCCT TTGGTACAGA CACGCTAATA AAGAAGAAGA ATGTTTTAAC CAACGTATTG 360

CGTCCTGACA ACCATAGAAA AAAGCCACAT ATAGTCATTA GTATGCCCCA AGACTTTAGA 420

40 CCTGTGTCTT CTATTATAGA CGTGGATATT CTCCCAGAAA CGCATCGTAG GGTACGTCTT 480

TACAAATACG GCACGGAGAA ACCCCTAGGA TTCTACATCC GGGATGGCTC CAGTGTCAGG 540

GTAACACCAC ATGGCTTAGA AAAGGTTCCA GGGATCTTTA TATCCAGGCT TGTCCCAGGA 600

GGTCTGGCTC AAAGTACAGG ACTATTAGCT GTTAATGATG AAGTTTTAGA AGTTAATGGC 660

ATAGAAGTTT CAGGGAAGAG CCTTGATCAA GTAACAGACA TGATGATTGC AAATAGCCGT 720

45 AACCTCATCA TAACAGTGAG ACCGGCAAAC CAGAGGAATA ATGTTGTGAG GAACAGTCGG 780

ACTTCTGGCA GTTCCGGTCA GTCTACTGAT AACAGCCTTC TTGGCTACCC ACAGCAGATT 840

GAACCAAGCT TTGAGCCAGA GGATGAAGAC AGCGAAGAAG ATGACATTAT CATTGAAGAC 900

AATGGAGTGC CACAGCAGAT TCCAAAAGCT GTTCCTAATA CTGAGAGCCT GGAGTCATTA 960

ACACAGATAG AGCTAAGCTT TGAGTCTGGA CAGAATGGCT TTATTCCCTC TAATGAAGTG 1020

50 AGCTTAGCAG CCATAGCAAG CAGCTCAAAC ACGGAATTTG AAACACATGC TCCAGATCAA 1080 AAACTCTTAG AAGAAGATGG AACAATCATA ACATTATGA

Seq ID NO: 26 Protein sequence Protein Accession #: XP_030559

55 1 11 21 31 41 51

I I I I I I

MNRSHRHGAG SGCLGTMEVK SKFGAEFRRF SLERSKPGKF EEFYGLLQHV HKIPNVDVLV 60

GYADIHGDLL PINNDDNYHK AVSTANPLLR IFIQKKEEAD YSAFGTDTLI KKKNVLTNVL 120

RPDNHRKKPH IVISMPQDFR PVSSIIDVDI LPETHRRVRL YKYGTEKPLG FYIRDGSSVR 180

60 VTPHGLEKVP GIFISRLVPG GLAQSTGLLA VNDEVLEVNG IEVSGKSLDQ VTDMMIANSR 240

NLIITVRPAN QRNNWRNSR TSGSSGQSTD NSLLGYPQQI EPSFEPEDED SEEDDIIIED 300

NGVPQQIPKA VPNTESLESL TQIELSFESG QNGFIPSNEV SLAAIASSSN TEFETHAPDQ 360 KLLEEDGTII TL

65 Seq ID NO: 27 DNA sequence

Nucleic Acid Accession #: NM_003667.1

Coding sequence: 1..2651

1 11 21 31 41 51

™ /U A ITGGACACCT C ICCGGCTCGG T IGTGCTCCTG T ICCTTGCCTG T IGCTGCTGCA G ICTGGCGACC 60

GGGGGCAGCT CTCCCAGGTC TGGTGTGTTG CTGAGGGGCT GCCCCACACA CTGTCATTGC 120

GAGCCCGACG GCAGGATGTT GCTCAGGGTG GACTGCTCCG ACCTGGGGCT CTCGGAGCTG 180

CCTTCCAACC TCAGCGTCTT CACCTCCTAC CTAGACCTCA GTATGAACAA CATCAGTCAG 240

CTGCTCCCGA ATCCCCTGCC CAGTCTCCGC TTCCTGGAGG AGTTACGTCT TGCGGGAAAC 300

75 GCTCTGACAT ACATTCCCAA GGGAGCATTC ACTGGCCTTT ACAGTCTTAA AGTTCTTATG 360

CTGCAGAATA ATCAGCTAAG ACACGTACCC ACAGAAGCTC TGCAGAATTT GCGAAGCCTT 420

CAATCCCTGC GTCTGGATGC TAACCACATC AGCTATGTGC CCCCAAGCTG TTTCAGTGGC 480

CTGCATTCCC TGAGGCACCT GTGGCTGGAT GACAATGCGT TAACAGAAAT CCCCGTCCAG 540

GCTTTTAGAA GTTTATCGGC ATTGCAAGCC ATGACCTTGG CCCTGAACAA AATACACCAC 600

80 ATACCAGACT ATGCCTTTGG AAACCTCTCC AGCTTGGTAG TTCTACATCT CCATAACAAT 660

AGAATCCACT CCCTGGGAAA GAAATGCTTT GATGGGCTCC ACAGCCTAGA GACTTTAGAT 720

TTAAATTACA ATAACCTTGA TGAATTCCCC ACTGCAATTA GGACACTCTC CAACCTTAAA 780

GAACTACATT TCTATGACAA TCCCATCCAA TTTGTTGGGA GATCTGCTTT TCAACATTTA 840

CCTGAACTAA GAACACTGAC TCTGAATGGT GCCTCACAAA TAACTGAATT TCCTGATTTA 900

85 ACTGGAACTG CAAACCTGGA GAGTCTGACT TTAACTGGAG CACAGATCTC ATCTCTTCCT 960 CAAACCGTCT GCAATCAGTT ACCTAATCTC CAAGTGCTAG ATCTGTCTTA CAACCTATTA 1020 GAAGATTTAC CCAGTTTTTC AGTCTGCCAA AAGCTTCAGA AAATTGACCT AAGACATAAT 1080 GAAATCTACG AAATTAAAGT TGACACTTTC CAGCAGTTGC TTAGCCTCCG ATCGCTGAAT 1140 TTGGCTTGGA ACAAAATTGC TATTATTCAC CCCAATGCAT TTTCCACTTT GCCATCCCTA 1200 ATAAAGCTGG ACCTATCGTC CAACCTCCTG TCGTCTTTTC CTATAACTGG GTTACATGGT 1260 TTAACTCACT TAAAATTAAC AGGAAATCAT GCCTTACAGA GCTTGATATC ATCTGAAAAC 1320 TTTCCAGAAC TCAAGGTTAT AGAAATGCCT TATGCTTACC AGTGCTGTGC ATTTGGAGTG 1380 TGTGAGAATG CCTATAAGAT TTCTAATCAA TGGAATAAAG GTGACAACAG CAGTATGGAC 1440 GACCTTCATA AGAAAGATGC TGGAATGTTT CAGGCTCAAG ATGAACGTGA CCTTGAAGAT 1500 TTCCTGCTTG ACTTTGAGGA AGACCTGAAA GCCCTTCATT CAGTGCAGTG TTCACCTTCC 1560 CCAGGCCCCT TCAAACCCTG TGAACACCTG CTTGATGGCT GGCTGATCAG AATTGGAGTG 1620 TGGACCATAG CAGTTCTGGC ACTTACTTGT AATGCTTTGG TGACTTCAAC AGTTTTCAGA 1680 TCCCCTCTGT ACATTTCCCC CATTAAACTG TTAATTGGGG TCATCGCAGC AGTGAACATG 1740 CTCACGGGAG TCTCCAGTGC CGTGCTGGCT GGTGTGGATG CGTTCACTTT TGGCAGCTTT 1800 GCACGACATG GTGCCTGGTG GGAGAATGGG GTTGGTTGCC ATGTCATTGG TTTTTTGTCC 1860 ATTTTTGCTT CAGAATCATC TGTTTTCCTG CTTACTCTGG CAGCCCTGGA GCGTGGGTTC 1920 TCTGTGAAAT ATTCTGCAAA ATTTGAAACG AAAGCTCCAT TTTCTAGCCT GAAAQTAATC 1980 ATTTTGCTCT GTGCCCTGCT GGCCTTGACC ATGGCCGCAG TTCCCCTGCT GGGTGGCAGC 2040 AAGTATGGCG CCTCCCCTCT CTGCCTGCCT TTGCCTTTTG GGGAGCCCAG CACCATGGGC 2100 TACATGGTCG CTCTCATCTT GCTCAATTCC CTTTGCTTCC TCATGATGAC CATTGCCTAC 2160 ACCAAGCTCT ACTGCAATTT GGACAAGGGA GACCTGGAGA ATATTTGGGA CTGCTCTATG 2220 GTAAAACACA TTGCCCTGTT GCTCTTCACC AACTGCATCC TAAACTGCCC TGTGGCTTTC 2280 TTGTCCTTCT CCTCTTTAAT AAACCTTACA TTTATCAGTC CTGAAGTAAT TAAGTTTATC 2340 CTTCTGGTGG TAGTCCCACT TCCTGCATGT CTCAATCCCC TTCTCTACAT CTTGTTCAAT 2400 CCTCACTTTA AGGAGGATCT GGTGAGCCTG AGAAAGCAAA CCTACGTCTG GACAAGATCA 2460 AAACACCCAA GCTTGATGTC AATTAACTCT GATGATGTCG AAAAACAGTC CTGTGACTCA 2520 ACTCAAGCCT TGGTAACCTT TACCAGCTCC AGCATCACTT ATGACCTGCC TCCCAGTTCC 2580 GTGCCATCAC CAGCTTATCC AGTGACTGAG AGCTGCCATC TTTCCTCTGT GGCATTTGTC 2640 CCATGTCTTA A

Seq ID NO: 28 Protein sequence Protein Accession #: NP_003658.1 1 11 21 31 41 51

I I I 1 1 I 1 I 1

MDTSRLGVLL SLPVLLQLAT GGSSPRSGVL LRGCPTHCHC EPDGRMLLRV DCSDLGLSEL 60 PSNLSVFTSY LDLSMNNISQ LLPNPLPSLR FLEELRLAGN ALTYIPKGAF TGLYSLKVLM 120 LQNNQLRHVP TEALQNLRSL QSLRLDANHI SYVPPSCFSG LHSLRHL LD DNALTEIPVQ 180 AFRSLΞΛLQA MTLALNKIHH IPDYAFGNLS SLWLHLHNN RIHSLGKKCF DGLHSLETLD 240 LNYNNLDEFP TAIRTLSNLK ELHFYDNPIQ FVGRSAFQHL PELRTLTLNG ASQITEFPDL 300 TGTANLESLT LTGAQISSLP QTVCNQLPNL QVLDLSYNLL EDLPSFSVCQ KLQKIDLRHN 360 EIYEIKVDTF QQLLSLRSLN LAWNKIAIIH PNAFSTLPSL IKLDLSSNLL SSFPITGLHG 420 LTHLKLTGNH ALQSLISSEN FPELKVIEMP YAYQCCAFGV CENAYKISNQ NKGDNSSMD 480 DLHKKDAGMF QAQDERDLED FLLDFEEDLK ALHΞVQCSPS PGPFKPCEHL LDGWLIRIGV 540 TIAVLALTC NALVTSTVFR SPLYISPIKL LIGVIAAVNM LTGVSSAVLA GVDAFTFGSF 600 ARHGA WENG VGCHVIGFLS IFASESSVFL LTLAALERGF SVKYSAKFET KAPFSSLKVI 660 ILLCALLALT MAAVPLLGGS KYGASPLCLP LPFGEPSTMG YMVALILLNS LCFLMMTIAY 720 TKLYCNLDKG DLENIWDCΞM VKHIALLLFT NCILNCPVAF LSFSSLINLT FISPEVIKFI 780 LLVWPLPAC LNPLLYILFN PHFKEDLVSL RKQTYVWTRS KHPSLMSINS DDVEKQSCDS 840 TQALVTFTSS SITYDLPPSS VPSPAYPVTE SCHLSSVAFV PCL

60

120 GCGACTGGCC GGCCATGCCT TCCCGGGCTG AGGACTATGA AGTGTTGTAC ACCATTGGCA 180 CAGGCTCCTA CGGCCGCTGC CAGAAGATCC GGAGGAAGAG TGATGGCAAG ATATTAGTTT 240 GGAAAGAACT TGACTATGGC TCCATGACAG AAGCTGAGAA ACAGATGCTT GTTTCTGAAG 300 TGAATTTGCT TCGTGAACTG AAACATCCAA ACATCGTTCG TTACTATGAT CGGATTATTG 360 ACCGGACCAA TACAACACTG TACATTGTAA TGGAATATTG TGAAGGAGGG GATCTGGCTA 420 GTGTAATTAC AAAGGGAACC AAGGAAAGGC AATACTTAGA TGAAGAGTTT GTTCTTCGAG 480 TGATGACTCA GTTGACTCTG GCCCTGAAGG AATGCCACAG ACGAAGTGAT GGTGGTCATA 540 CCGTATTGCA TCGGGATCTT AAACCAGCCA ATGTTTTCCT GGATGGCAAG CAAAACGTCA 600 AGCTTGGAGA CTTTGGGCTA GCTAGAATAT TAAACCATGA CACGAGTTTT GCAAAAACAT 660 TTGTTGGCAC ACCTTATTAC ATGTCTCCTG AACAAATGAA TCGCATGTCC TACAATGAGA 720 AATCAGATAT CTGGTCATTG GGCTGCTTGC TGTATGAGTT ATGTGCATTA ATGCCTCCAT 780 TTACAGCTTT TAGCCAGAAA GAACTCGCTG GGAAAATCAG AGAAGGCAAA TTCAGGCGAA 840 TTCCATACCG TTACTCTGAT GAATTGAATG AAATTATTAC GAGGATGTTA AACTTAAAGG 900 ATTACCATCG ACCTTCTGTT GAAGAAATTC TTGAGAACCC TTTAATAGCA GATTTGGTTG 960 CAGACGΛGCA AAGAAGAAAT CTTGAGAGAA GAGGGCGACA ATTAGGAGAG CCAGAAAAAT 1020 CGCAGGATTC CAGCCCTGTA TTGAGTGAGC TGAAACTGAA GGAAATTCAG TTACAGGAGC 1080 GAGAGCGAGC TCTCAAAGCA AGAGAAGAAA GATTGGAGCA GAAAGAACAG GAGCTTTGTG 1140 TTCGTGAGAG ACTAGCAGAG GACAAACTGG CTAGAGCAGA AAATCTGTTG AAGAACTACA 1200 GCTTGCTAAA GGAACGGAAG TTCCTGTCTC TGGCAAGTAA TCCAGAACTT CTTAATCTTC 1260 CATCCTCAGT AATTAAGAAG AAAGTTCATT TCAGTGGGGA AAGTAAAGAG AACATCATGA 1320 GGAGTGAGAA TTCTGAGAGT CAGCTCACAT CTAAGTCCAA GTGCAAGGAC CTGAAGAAAA 1380 GGCTTCACGC TGCCCAGCTG CGGGCTCAAG CCCTGTCAGA TATTGAGAAA AATTACCAAC 1440 TGAAAAGCAG ACAGATCCTG GGCATGCGCT AGCCAGGTAG AGAGACACAG AGCTGTGTAC 1500 AGGATGTAAT ATTACCAACC TTTAAAGACT GATATTCAAA TGCTGTAGTG TTGAATACTT 1560 GGCCCCATGA GCCATGCCTT TCTGTATAGT ACACATGATA TTTCGGAATT GGTTTTACTG 1620 TTCTTCAGCA ACTATTGTAC AAAATGTTCA CATTTAATTT TTCTTTCTTC TTTTAAGAAC 1680 ATATTATAAA AAGAATACTT TCTTGGTTGG GCTTTTAATC CTGTGTGTGA TTACTAGTAG 1740 GAACATGAGA TGTGACATTC TAAATCTTGG GAGAAAAAAT AATATTAGGA AAAAAATATT 1800 TATGCAGGAA GAGTAGCACT CACTGAATAG TTTTAAATGA CTGAGTGGTA TGCTTACAAT 1860 TGTCATGTCT AGATTTAAAT TTTAAGTCTG AGATTTTAAA TGTTTTTGAβ CTTAGAAAAC 1920 CCAGTTAGAT GCAATTTGGT CATTAATACC ATGACATCTT GCTTATAAAT ATTCCATTGC 1980 TCTGTAGTTC AAATCTGTTA GCTTTGTGAA AATTCATCAC TGTGATGTTT GTATTCTTTT 2040 TTTTTTTCTG TTTAACAGAA TATGAGCTGT CTGTCATTTA CCTACTTCTT TCCCACTAAA 2100 TAAAAGAATT CTTCAGTTA

Seq ID NO: 30 Protein sequence Protein Accession #: NP_002488.1 1 11 21

I I I

MPSRAEDYEV LYTIGTGSYG RCQKIRRKSD GKILV KELD YGSMTEAEKQ MLVSEVNLLR 60 ELKHPNIVRY YDRIIDRTNT TLYIVMEYCE GGDLASVITK GTKERQYLDE EFVLRVMTQL 120 TLALKECHRR SDGGHTVLHR DLKPANVFLD GKQNVKLGDF GLARILNHDT SFAKTFVGTP 180 YYMSPEQMNR MSYNEKSDIW SLGCLLYELC ALMPPFTAFS QKELAGKIRE GKFRRIPYRY 240 SDELNEΪITR MLNLKDYHRP SVEEILENPL IADLVADEQR RNLERRGRQL GEPEKSQDSS 300 PVLSELKLKE IQLQERERAL KAREERLEQK EQELCVRERL AEDKLARAEN LLKNYSLLKE 360 RKFLSLASNP ELLNLPSSVI KKKVHFSGES KENIMRSENS ESQLTSKSKC KDLKKRLHAA 420 QLRAQALSDI EKNYQLKSRQ ILGMR

Seq ID NO: 31 DNA sequence

Nucleic Acid Accession ft: NM_020242

Coding sequence: 72.. 240

1 11 21 31 51

I I I ^' I

CAGTCGCGCG CGGTGCAGTC GGGAGGTGGA GGCACCGGCT GCATTGTTTT CGGGATCGAG 60 GGGTGAGGGC GCTATGGCAC CCGGCTGCAA AACTGAGTTA CGCAGCGTGA CAAATGGTCA 120 GTCTAACCAA CCAAGTAATG AAGGTGATGC CATCAAAGTT TTTGTGCGAA TTCGTCCTCC 180 TGCAGAAAGA TCTGGGTCAG CTGATGGAGA GCAGAACTTA TGCTTATCTG TGCTGTCCTC 240 CACGAGTCTC CGGCTGCACT CCAACCCTGA GCCCAAGACC TTCACGTTTG ATCATGTTGC 300 AGATGTGGAT ACCACTCAGG AATCTGTATT TGCAACTGTG GCTAAAAGCA TTGTGGAGTC 360 TTGCATGAGC GGTTATAATG GTACCATCTT TGCATATGGA CAGACTGGCT CAGGGAAGAC 420 ATTTACTATG ATGGGACCAT CTGAATCTGA TAATTTTTCT CATAACCTGA GAGGAGTAAT 480 CCCACGAAGT TTTGAATATT TGTTTTCCTT AATTGATCGT GAAAAAGAAA AGGCTGGAGC 540 TGGAAAGAGT TTCCTTTGTA AGTGTTCCTT TATTGAAATC TACAACGAGC AGATATATGA 600 TCTACTGGAC TCTGCATCGG CTGGACTGTA CTTAAGGGAG CATATCAAGA AGGGAGTCTT 660 TGTTGTTGGT GCGGTGGAGC AGGTGGTAAC CTCAGCTGCT GAAGCCTATC AGGTGCTGTC 720 TGGAGGATGG AGGAATAGAC GTGTGGCATC AACATCAATG AACAGAGAAT CGTCTAGGTC 780 TCATGCCGTC TTTACAATTA CAATAGAGTC AATGGAGAAA AGTAATGAGA TTGTGAATAT 840 ACGGACCTCC CTACTCAACC TGGTGGATTT AGCAGGATCT GAAAGGCAAA AAGATACCCA 900 TGCAGAAGGG ATGAGATTGA AGGAAGCAGG TAACATAAAT CGATCATTGA GCTGCCTGGG 960 CCAAGTGATT ACAGCACTTG TCGACGTGGG TAATGGAAAA CAGAGACATG TTTGCTACAG 1020 AGACTCCAAA CTTACCTTCT TACTACGGGA TTCCCTTGGA GGTAATGCCA AAACAGCCAT 1080 AATTGCAAAT GTTCATCCTG GATCCAGGTG TTTTGGGGAA ACCCTATCAA CACTTAACTT 1140 TGCTCAAAGA GCCAAGCTGA TTAAAAACAA GGCAGTAGTA AATGAAGACA CCCAAGGAAA 1200 TGTGAGCCAG CTCCAAGCTG AAGTGAAGAG GCTCAAAGAA CAACTGGCGG AGCTTGCTTC 1260 AGGACAGACA CCACCAGAAA GCTTCCTGAC CAGAGACAAA AAGAAGACTA ACTATATGGA 1320 GTATTTCCAG GAAGCAATGT TATTCTTTAA GAAATCTGAA CAGGAAAAGA AGTCTCTGAT 1380 AGAAAAAGTT ACCCAATTAG AAGACCTCAC CCTCAAAAAG GAAAAATTTA TTCAATCTAA 1440 TAAAATGATT GTGAAATTCC GAGAGGATCA AATAATACGC TTGGAAAAGC TCCACAAGGA 1500 ATCCCGGGGA GGTTTTCTGC CTGAGGAGCA GGATCGTTTG CTCTCAGAAT TAAGGAATGA 1560 GATTCAAACT CTGCGAGAAC AAATAGAGCA CCACCCCAGA GTTGCAAAGT ATGCTATGGA 1620 AAATCATTCC CTCAGGGAGG AGAATAGAAG ACTGAGATTA TTAGAGCCTG TGAAAAGAGC 1680 TCAAGAAATG GATGCCCAGA CCATTGCAAA ACTAGAAAAA GCTTTCTCTG AAATAAGTGG 1740 CATGGAGAAA AGTGACAAAA ATCAGCAAGG ATTTTCACCT AAAGCTCAGA AAGAGCCATG 1800 TTTGTTTGCA AACAGTGAGA AGTTAAAAGC ACAACTCCTG CAAATTCAGA CAGAGCTGAA 1860 TAATTCAAAG CAAGAATATG AAGAATTCAA AGAACTTACT AGGAAAAGGC AGCTAGAATT 1920 GGAATCAGAG CTTCAGTCTT TGCAAAAAGC GAACCTTAAT CTTGAAAACC TTTTGGAAGC 1980 AACAAAAGCC TGCAAGCGGC AAGAAGTTTC TCAGCTGAAT AAAATTCATG CTGAAACACT 2040 TAAGATTATA ACTACACCAA CCAAGGCCTA CCAACTTCAT TCCCGACCAG TACCAAAATT 2100 AAGCCCTGAA ATGGGAAGCT TTGGCTCTCT ATACACTCAG AATTCTAGCA TATTAGATAA 2160 TGATATATTA AATGAGCCAG TTCCTCCTGA GATGAATGAA CAAGCTTTTG AGGCCATTTC 2220 TGAAGAGCTT AGAACAGTGC AGGAACAAAT GAGTGCTCTT CAAGCCAAAC TGGATGAAGA 2280 AGAGCATAAA AACCTAAAGC TTCAGCAGCA TGTTGACAAA CTGGAACATC ATTCTACCCA 2340 AATGCAGGAG CTTTTCTCAT CAGAAAGAAT TGATTGGACC AAACAGCAGG AAGAGCTTCT 2400 CTCACAGTTG AATGTCCTTG AAAAGCAGCT TCAAGAGACT CAAACTAAAA ATGACTTTTT 2460 GAAAAGTGAG GTACATGACC TGCGAGTAGT CCTTCATTCT GCTGACAAGG AGCTTTCTTC 2520 AGTGAAATTG GAATATAGTT CATTCAAAAC GAATCAGGAG AAAGAATTCA ACAAACTTTC 2580 TGAAAGACAC ATGCATGTAC AGCTTCAATT AGATAATCTC AGGTTAGAAA ACGAAAAGCT 2640 GCTTGAGAGC AAAGCCTGCC TACAGGATTC CTATGACAAC TTACAAGAAA TAATGAAATT 2700 TGAGATTGAC CAACTTTCAA GAAACCTCCA AAACTTCAAA AAAGAAAATG AAACTCTGAA 2760 ATCTGATCTG AATAATTTGA TGGAGCTTCT TGAGGCAGAA AAAGAACGCA ATAACAAATT 2820 ATCATTACAG TTTGAAGAAG ATAAAGAAAA CAGTTCTAAA GAAATCTTAA AAGTTCTTGA 2880 GGCTGTACGT CAGGAGAAAC AGAAAGAGAC GGCCAAGTGT GAGCAGCAGA TGGCAAAAGT 2940 ACAGAAACTA GAAGAGAGCT TGCTTGCTAC TGAAAAAGTG ATCAGTTCCC TGGAAAAGTC 3000 TAGAGATTCT GATAAGAAAG TTGTAGCTGA CCTCATGAAC CAGATCCAGG AGCTAAGAAC 3060 ATCGGTCTGT GAGAAAACAG AAACTATAGA CACCCTGAAA CAAGAACTGA AGGACATAAA 3120 TTGCAAATAC AACTCTGCTT TGGTTGACAG AGAAGAGAGC AGAGTGTTGA TCAAGAAGCA 3180 GGAAGTGGAT ATTCTGGATC TGAAAGAAAC CCTTAGGCTG AGAATACTTT CTGAGGACAT 3240 AGAGAGGGAT ATGCTCTGTG AGGACCTGGC TCATGCCACT GAGCAGCTGA ACATGCTCAC 3300 AGAGGCCTCA AAAAAACACT CGGGGCTGCT GCAGTCTGCC CAGGAAGAAC TGACCAAGAA 3360 GGAAGCCCTG ATTCAGGAAC TTCAGCACAA GCTAAACCAA AAGAAAGAGG AAGTAGAACA 3420 GAAGAAGAAT GAATATAACT TCAAAATGAG GCAACTAGAA CATGTGATGG ATTCTGCTGC 3480 TGAGGATCCC CAGAGTCCTA AGACACCACC TCACTTTCAA ACACATTTGG CAAAACTCCT 3540 GGAAACACAA GAACAAGAGA TAGAAGATGG AAGAGCCTCT AAGACTTCTT TGGAACACCT 3600 TGTAACAAAG CTAAATGAAG ACAGAGAAGT CAAAAATGCT GAAATCCTCA GAATGAAGGA 3660 GCAGTTGCGT GAAATGGAAA ACCTACGCCT GGAAAGTCAG CAGTTAATAG AGAAAAACTG 3720 GCTCCTGCAA GGTCAGCTGG ATGATATTAA AAGACAAAAG GAAAACAGTG ATCAGAATCA 3780 TCCAGATAAT CAACAGCTGA AGAATGAACA AGAAGAAAGT ATCAAAGAAA GACTTGCAAA 3840 AAGTAAAATA GTTGAAGAAA TGCTGAAAAT GAAAGCAGAC CTAGAAGAAG TCCAAAGTGC 3900 CCTTTACAAC AAAGAGATGG AATGCCTTAG AATGACTGAT GAAGTCGAAC GAACCCAAAC 3960 TTTGGAGTCT AAAGCATTCC AGGAAAAAGA ACAACTGAGA TCAAAGCTGG AAGAAATGTA 4020 TGAAGAAAGA GAGAGAACAT CCCAGGAGAT GGAAATGTTA AGGAAGCAGG TGGAGTGTCT 4080 TGCTGAGGAA AATGGAAAGT TGGTAGGTCA CCAAAATTTG CATCAGAAGA TTCAGTACGT 4140 AGTGCGACTA AAGAAGGAAA ATGTCAGGCT TGCTGAGGAG ACAGAAAAGT TGCGTGCCGA 4200 AAATGTATTT TTAAAAGAAA AGAAAAGAAG TGAATCTTGA GGATTCCGGT CAGCTACCTA 4260 GGCATCACCT TGTTTGAAGA TGTTTCTTCT CTTTTACAAG TAAGACCTAC TCCTGGCCAC 4320 TTAGGAGAGC TGAATTTATG GACCTTAATT ATTAAATGTT TATAAGGTGG TGGTAACCAC 4380 CTCAAGTTTC TGATGAACAT TCTGCATCCA TATACACCCT GTGACAGTCA GCAGTCTGCT 4440 ATTAAGTGGC CTACTTCAAG GCTTTGAATC AACTTAAGGG AAAACCTTTT GTCTTTGTAA 4500 AAATAAAAGC CTGTAGCTAA GGTTTACAGT GGACATTAGC CAGATCATTT TCTTCTTAGA 4560 TTATGCCATA ATCTCCTTTG ATTCTTATGG AAGTTCTAAC AATATATGGT GGTTCCAACA 4620 CCTGCAGTGA GTTTAATGAC TGACTTAGTA GCAGGTACAA GAAGCAAACT TGTTAATATA 4680 GATTATTTTT GTATTCTTAC TTTAGGTATT TTACTTGAGC ATTTTCCATG ACTGTAAATA 4740 AAGCCATTTT TTAAGATAAA AAAAAAAAAA AAAAA

Seq ID NO : 32 Protein sequence Protein Accession ft: NP_064627 1 11 21 31 41 51

I I

MAPGCKTELR SVTNGQSNQP SNEGDAIKVF VRIRPPAERS GSADGEQNLC LSVLSSTSLR 60 LHSNPEPKTF TFDHVADVDT TQESVFATVA KSIVESCMSG YNGTIFAYGQ TGSGKTFTMM 120 GPSESDNFSH NLRGVIPRSF EYLFSLIDRE KEKAGAGKSF LCKCSFIEIY NEQIYDLLDS 180 ASAGLYLREH IKKGVFWGA VEQWTSAAE AYQVLSGGWR NRRVASTSMN RESSRSHAVF 240 TITIESMEKS NEIVNIRTSL LNLVDLAGSE RQKDTHAEGM RLKEAGNINR SLSCLGQVIT 300 ALVDVGNGKQ RHVCYRDSKL TFLLRDSLGG NAKTAIIANV HPGSRCFGET LSTLNFAQRA 360 KLIKNKAWN EDTQGNVSQL QAEVKRLKEQ LAELASGQTP PESFLTRDKK KTNYMEYFQE 420 AMLFFKKSEQ EKKSLIEKVT QLEDLTLKKE KFIQSNKMIV KFREDQIIRL EKLHKESRGG 480 FLPEEQDRLL SELRNEIQTL REQIEHHPRV AKYAMENHSL REENRRLRLL EPVKRAQEMD 540 AQTIAKLEKA FSEISGMEKS DKNQQGFSPK AQKEPCLFAN TEKLKAQLLQ IQTELNNSKQ 600 EYEEFKELTR KRQLELESEL QSLQKANLNL ENLLEATKAC KRQEVSQLNK IHAETLKIIT 660 TPTKAYQLHS RPVPKLSPEM GSFGSLYTQN SSILDNDILN EPVPPEMNEQ AFEAIΞEELR 720 TVQEQMSALQ AKLDEEEHKN LKLQQHVDKL EHHSTQMQEL FSSERID TK QQEELLSQLN 780 VLEKQLQETQ TKNDFLKSEV HDLRWLHSA DKELSSVKLE YSSFKTNQEK EFNKLSERHM 840 HVQLQLDNLR LENEKLLESK ACLQDSYDNL QEIMKFEIDQ LSRNLQNFKK ENETLKSDLN 900 NLMELLEAEK ERNNKLSLQF EEDKENSSKE I KVLEAVRQ EKQKETAKCE QQMAKVQKLE 960 ESLLATEKVI SSLEKSRDSD KKWADLMNQ IQELRTSVCE KTETIDTLKQ ELKDINCKYN 1020 SALVDREESR VLIKKQEVDI LDLKETLRLR ILSEDIERDM LCEDLAHATE QLNMLTEASK 1080 KHSGLLQSAQ EELTKKEALI QELQHKLNQK KEEVEQKKNE YNFKMRQLEH VMDSAAEDPQ 1140 SPKTPPHFQT HLAKLLETQE QEIEDGRASK TSLEHLVTKL NEDREVKNAE ILRMKEQLRE 1200 MENLRLESQQ LIEKNWLLQG QLDDIKRQKE NSDQNHPDNQ QLKNEQEESI KERLAKSKIV 1260 EEMLKMKADL EEVQSALYNK EMECLRMTDE VERTQTLESK AFQEKEQLRS KLEEMYEERE 1320 RTSQEMEMLR KQVECLAEEN GKLVGHQNLH QKIQYWRLK KENVRLAEET EKLRAENVFL 1380 KEKKRSES

Seq ID NO: 33 DNA sequence

Nucleic Acid Accession ft: BC000633.1

Coding sequence: 1..2574

1 11 21 31 41 51

I I

ATGGAATCCG AGGATTTAAG TGGCAGAGAA TTGACAATTG ATTCCATAAT GAACAAAGTG 60 AGAGACATTA AAAATAAGTT TAAAAATGAA GACCTTACTG ATGAACTAAG CTTGAATAAA 120 ATTTCTGCTG ATACTACAGA TAACTCGGGA ACTGTTAACC AAATTATGAT GATGGCAAAC 180 AACCCAGAGG ACTGGTTGAG TTTGTTGCTC AAACTAGAGA AAAACAGTGT TCCGCTAAGT 240 GATGCTCTTT TAAATAAATT GATTGGTCGT TACAGTCAAG CAATTGAAGC GCTTCCCCCA 300 GATAAATATG GCCAAAATGA GAGTTTTGCT AGAATTCAAG TGAGATTTGC TGAATTAAAA 360 GCTATTCAAG AGCCAGATGA TGCACGTGAC TACTTTCAAA TGGCCAGAGC AAACTGCAAG 420 AAATTTGCTT TTGTTCATAT ATCTTTTGCA CAATTTGAAC TGTCACAAGG TAATGTCAAA 480 AAAAGTAAAC AACTTCTTCA AAAAGCTGTA GAACGTGGAG CAGTACCACT AGAAATGCTG 540 GAAATTGCCC TGCGGAATTT AAACCTCCAA AAAAAGCAGC TGCTTTCAGA GGAGGAAAAG 600 AAGAATTTAT CAGCATCTAC GGTATTAACT GCCCAAGAAT CATTTTCCGG TTCACTTGGG 660 CATTTACAGA ATAGGAACAA CAGTTGTGAT TCCAGAGGAC AGACTACTAA AGCCAGGTTT 720 TTATATGGAG AGAACATGCC ACCACAAGAT GCAGAAATAG GTTACCGGAA TTCATTGAGA 780 CAAACTAACA AAACTAAACA GTCATGCCCA TTTGGAAGAG TCCCAGTTAA CCTTCTAAAT 840 AGCCCAGATT GTGATGTGAA GACAGATGAT TCAGTTGTAC CTTGTTTTAT GAAAAGACAA 900 ACCTCTAGAT CAGAATGCCG AGATTTGGTT GTGCCTGGAT CTAAACCAAG TGGAAATGAT 960 TCCTGTGAAT TAAGAAATTT AAAGTCTGTT CAAAATAGTC ATTTCAAGGA ACCTCTGGTG 1020 TCAGATGAAA AGAGTTCTGA ACTTATTATT ACTGATTCAA TAACCCTGAA GAATAAAACG 1080 GAATCAAGTC TTCTAGCTAA ATTAGAAGAA ACTAAAGAGT ATCAAGAACC AGAGGTTCCA 1140 GAGAGTAACC AGAAACAGTG GCAATCΓAAG AGAAAGTCAG AGTGTATTAA CCAGAATCCT 1200 GCTGCATCTT CAAATCACTG GCAGATTCCG GAGTTAGCCC GAAAAGTTAA TACAGAGCAG 1260 AAACATACCA CTTTTGAGCA ACCTGTCTTT TCAGTTTCAA AACAGTCACC ACCAATATCA 1320 ACATCTAAAT GGTTTGACCC AAAATCTATT TGTAAGACAC CAAGCAGCAA TACCTTGGAT 1380 GATTACATGA GCTGTTTTAG AACTCCAGTT GTAAAGAATG ACTTTCCACC TGCTTGTCAG 1440 TTGTCAACAC CTTATGGCCA ACCTGCCTGT TTCCAGCAGC AACAGCATCA AATACTTGCC 1500 ACTCCACTTC AAAATTTACA GGTTTTAGCA TCTTCTTCAG CAAATGAATG CATTTCGGTT 1560 AAAGGAAGAA TTTATTCCAT TTTAAAGCAG ATAGGAAGTG GAGGTTCAAG CAAGGTATTT 1620 CAGGTGTTAA ATGAAAAGAA ACAGATATAT GCTATAAAAT ATGTGAACTT AGAAGAAGCA 1680 GATAACCAAA CTCTTGATAG TTACCGGAAC GAAATAGCTT ATTTGAATAA ACTACAACAA 1740 CACAGTGATA AGATCATCCG ACTTTATGAT TATGAAATCA CGGACCAGTA CATCTACATG 1800 GTAATGGAGT GTGGAAATAT TGATCTTAAT AGTTGGCTTA AAAAGAAAAA ATCCATTGAT 1860 CCATGGGAAC GCAAGAGTTA CTGGAAAAAT ATGTTAGAGG CAGTTCACAC AATCCATCAA 1920 CATGGCATTG TTCACAGTGA TCTTAAACCA GCTAACTTTC TGATAGTTGA TGGAATGCTA 1980 AAGCTAATTG ATTTTGGGAT TGCAAACCAA ATGCAACCAG ATACAACAAG TGTTGTTAAA 2040 GATTCTCAGG TTGGCACAGT TAATTATATG CCACCAGAAG CAATCAAAGA TATGTCTTCC 2100 TCCAGAGAGA ATGGGAAATC TAAGTCAAAG ATAAGCCCCA AAAGTGATGT TTGGTCCTTA 2160 GGATGTATTT TGTACTATAT GACTTACGGG AAAACACCAT TTCAGCAGAT AATTAATCAG 2220 ATTTCTAAAT TACATGCCAT AATTGATCCT AATCATGAAA TTGAATTTCC CGATATTCCA 2280 GAGAAAGATC TTCAAGATGT GTTAAAGTGT TGTTTAAAAA GGGACCCAAA ACAGAGGATA 2340 TCCATTCCTG AGCTCCTGGC TCATCCCTAT GTTCAAATTC AAACTCATCC AGTTAACCAA 2400 ATGGCCAAGG GAACCACTGA AGAAATGAAA TATGTTCTGG GCCAACTTGT TGGTCTGAAT 2460 TCTCCTAACT CCATTTTGAA AGCTGCTAAA ACTTTATATG AACACTATAG TGGTGGTGAA 2520 AGTCATAATT CTTCATCCTC- CAAGACTTTT GAAAAAAAAA GGGGAAAAAA ATGA

Seq ID NO: 34 Protein sequence: Protein Accession ft: AAH00633.1 1 11 21 31

I I I

MESEDLSGRE LTIDSIMNKV RDIKNKFKNE DLTDELSLNK ISADTTDNΞG TVNQIMMMAN 60 NPEDWLSLLL KLEKNSVPLS DALLNKLIGR YSQAIEALPP DKYGQNESFA RIQVRFAELK 120 AIQEPDDARD YFQMARANCK KFAFVHISFA QFELSQGNVK KSKQLLQKAV ERGAVPLEML 180 EIALRNLNLQ KKQLLSEEEK KNLSASTVLT AQESFSGSLG HLQNRNNSCD SRGQTTKARF 240 LYGENMPPQD AEIGYRNSLR QTNKTKQSCP FGRVPVNLLN SPDCDVKTDD SWPCFMKRQ 300 TSRSECRDLV VPGSKPSGND SCELRNLKSV QNSHFKEPLV SDEKSSELII TDSITLKNKT 360 ESSLLAKLEE TKEYQEPEVP ESNQKQ QSK RKSECINQNP AASSNHWQIP ELARKVNTEQ 420 KHTTFEQPVF SVSKQSPPIS TSKWFDPKSI C^"KTPSSNTLD DYMSCFRTPV VKNDFPPACQ 480 LSTPYGQPAC FQQQQHQILA TPLQNLQVLA SSSANECISV KGRIYSILKQ IGSGGSSKVF 540 QVLNEKKQIY AIKYVNLEEA DNQTLDSYRN EIAYLNKLQQ HSDKIIRLYD YEITDQYIYM 600 VMECGNIDLN S LKKKKSID PWERKSY KN MLEAVHTIHQ HGIVHSDLKP ANFLIVDGML 660 KLIDFGIANQ MQPDTTSWK DSQVGTVNYM PPEAIKDMSS SRENGKSKSK ISPKSDVWSL 720 GCILYYMTYG KTPFQQIINQ ISKLHAIIDP NHEIEFPDIP EKDLQDVLKC CLKRDPKQRI 780 SIPELLAHPY VQIQTHPVNQ MAKGTTEEMK YVLGQLVGLN SPNSILKAAK TLYEHYSGGE 840 SHNSSSSKTF EKKRGKK

Seq ID NO: 35 DNA sequence

Nucleic Acid Accession #: NM_005823.2

Coding sequence: 85..1953

1 11 ' 21 31 41 51

I I I I

TGGCCACTCC CGTCTGCTGT GACGCGCGGA CAGAGAGCTA CCGGTGGACC CACGGTGCCT 60 CCCTCCCTGG GATCTACACA GACCATGGCC TTGCCAACGG CTCGACCCCT GTTGGGGTCC 120 TGTGGGACCC CCGCCCTCGG CAGCCTCCTG TTCCTGCTCT TCAGCCTCGG ATGGGTGCAG 180 CCCTCGAGGA CCCTGGCTGG AGAGACAGGG CAGGAGGCTG CACCCCTGGA CGGAGTCCTG 240 GCCAACCCAC CTAACATTTC CAGCCTCTCC CCTCGCCAAC TCCTTGGCTT CCCGTGTGCG 300 GAGGTGTCCG GCCTGAGCAC GGAGCGTGTC CGGGAGCTGG CTGTGGCCTT GGCACAGAAG 360 AATGTCAAGC TCTCAACAGA GCAGCTGCGC TGTCTGGCTC ACCGGCTCTC TGAGCCCCCC 420 GAGGACCTGG ACGCCCTCCC ATTGGACCTG CTGCTATTCC TCAACCCAGA TGCGTTCTCG 480 GGGCCCCAGG CCTGCACCCG TTTCTTCTCC CGCATCACGA AGGCCAATGT GGACCTGCTC 540 CCGAGGGGGG CTCCCGAGCG ACAGCGGCTG CTGCCTGCGG CTCTGGCCTG CTGGGGTGTG 600 CGGGGGTCTC TGCTGAGCGA GGCTGATGTG CGGGCTCTGG GAGGCCTGGC TTGCGACCTG 660 CCTGGGCGCT TTGTGGCCGA GTCGGCCGAA GTGCTGCTAC CCCGGCTGGT GAGCTGCCCG 720 GGACCCCTGG ACCAGGACCA GCAGGAGGCA GCCAGGGCGG CTCTGCAGGG CGGGGGACCC 780 CCCTACGGCC CCCCGTCGAC ATGGTCTGTC TCCACGATGG ACGCTCTGCG GGGCCTGCTG 840 CCCGTGCTGG GCCAGCCCAT CATCCGCAGC ATCCCGCAGG GCATCGTGGC CGCGTGGCGG 900 CAACGCTCCT CTCGGGACCC ATCCTGGCGG CAGCCTGAAC GGACCATCCT CCGGCCGCGG 960 TTCCGGCGGG AAGTGGAGAA GACAGCCTGT CCTTCAGGCA AGAAGGCCCG CGAGATAGAC 1020 GAGAGCCTCA TCTTCTACAA GAAGTGGGAG CTGGAAGCCT GCGTGGATGC GGCCCTGCTG ^' 1080 GCCACCCAGA TGGACCGCGT GAACGCCATC CCCTTCACCT ACGAGCAGCT GGACGTCCTA 1140 AAGCATAAAC TGGATGAGCT CTACCCACAA GGTTACCCCG AGTCTGTGAT CCAGCACCTG 1200 GGCTACCTCT TCCTCAAGAT GAGCCCTGAG GACATTCGCA AGTGGAATGT GACGTCCCTG 1260 GAGACCCTGA AGGCTTTGCT TGAAGTCAAC AAAGGGCACG AAATGAGTCC TCAGGTGGCC 1320 ACCCTGATCG ACCGCTTTGT GAAGGGAAGG GGCCAGCTAG ACAAAGACAC CCTAGACACC 1380 CTGACCGCCT TCTACCCTGG GTACCTGTGC TCCCTCAGCC CCGAGGAGCT GAGCTCCGTG 1440 CCCCCCAGCA GCATCTGGGC GGTCAGGCCC CAGGACCTGG ACACGTGTGA CCCAAGGCAG 1500 CTGGACGTCC TCTATCCCAA GGCCCGCCTT GCTTTCCAGA ACATGAACGG GTCCGAATAC 1560 TTCGTGAAGA TCCAGTCCTT CCTGGGTGGG GCCCCCACGG AGGATTTGAA GGCGCTCAGT 1620 CAGCAGAATG TGAGCATGGA CTTGGCCACG TTCATGAAGC TGCGGACGGA TGCGGTGCTG 1680 CCGTTGACTG TGGCTGAGGT GCAGAAACTT CTGGGACCCC ACGTGGAGGG CCTGAAGGCG 1740 GAGGAGCGGC ACCGCCCGGT GCGGGACTGG ATCCTACGGC AGCGGCAGGA CGACCTGGAC 1800 ACGCTGGGGC TGGGGCTACA GGGCGGCATC CCCAACGGCT ACCTGGTCCT AGACCTCAGC 1860 GTGCAAGAGG CCCTCTCGGG GACGCCCTGC CTCCTAGGAC CTGGACCTGT TCTCACCGTC 1920 CTGGCACTGC TCCTAGCCTC CACCCTGGCC TGAGGGCCCC ACTCCCTTGC TGGCCCCAGC 1980 CCTGCTGGGG ATCCCCGCCT GGCCAGGAGC AGGCACGGGT GATCCCCGTT CCACCCCAAG 2040 GAACTCGCG CTCAGTAAAC GGGAACATGC CCCCTGCAGA CACGT

Seq ID NO: 36 Protein sequence Protein Accession ft: NP_005814.1 1 11 21 31 41 51

I 1 I 1 1 11 11

MALPTARPLL GSCGTPALGS LLFLLFSLGW VQPSRTLAGE TGQEAAPLDG VLANPPNISS 60 LSPRQLLGFP CAEVSGLSTE RVRELAVALA QKNVKLSTEQ LRCLAHRLSE PPEDLDALPL 120 DLLLFLNPDA FSGPQACTRF FSRITKANVD LLPRGAPERQ RLLPAALAC GVRGSLLSEA 180 DVRALGGLAC DLPGRFVAES AEVLLPRLVS CPGPLDQDQQ EAARAALQGG GPPYGPPSTW 240 SVSTMDALRG LLPVLGQPII RSIPQGIVAA WRQRSSRDPS WRQPERTILR PRFRREVEKT 300 ACPSGKKARE IDESLIFYKK WELEACVDAA LLATQMDRVN AIPFTYEQLD VLKHKLDELY 360 PQGYPESVIQ HLGYLFLKMS PEDIRKWNVT SLETLKALLE VNKGHEMSPQ VATLIDRFVK 420

GRGQLDKDTL DTLTAFYPGY LCSLSPEELS SVPPSSIWAV RPQDLDTCDP RQLDVLYPKA 480

RLAFQNMNGS EYFVK1QSFL GGAPTEDLKA LSQQNVSMDL ATFMKLRTDA VLPLTVAEVQ 540

KLLGPHVEGL KAEERHRPVR DWILRQRQDD LDTLGLGLQG GIPNGYLVLD LSVQEALSGT 600 PCLLGPGPVL TVLALLLAST LA

Seq ID NO: 37 DNA sequence Nucleic Acid Accession ft: NM_013404.1 Coding sequence: 89..1975 1 11 21 31 41 51

I I I I I I

TGGCCGGCCA CTCCCGTCTG CTGTGACGCG CGGACAGAGA GCTACCGGTG GACCCACGGT 60

GCCTCCCTCC CTGGGATCTA CACAGACCAT GGCCTTGCAA CGGCTCGACC CCTGTTGGTC 120

CTGTGGGGAC CGCCCTGGCA GCCTCCTGTT CCTGCTCTTC AGCCTCGGAT GGGTGCATCC 180 CGCGAGGACC CTGGCTGGAG AGACAGGGAC GGAGTCTGCC CCCCTGGGGG GAGTCCTGAC 240

AACCCCCCAT AACATTTCCA GCCTCTCCCC TCGCCAACTC CTTGGCTTCC CGTGTGCGGA 300

GGTGTCCGGC CTGAGCACGG AGCGTGTCCG GGAGCTGGCT GTGGCCTTGG CACAGAAGAA 360

TGTCAAGCTC TCAACAGAGC AGCTGCGCTG TCTGGCTCAC CGGCTCTCTG AGCCCCCCGA 420

GGACCTGGAC GCCCTCCCAT TGGACCTGCT GCTATTCCTC AACCCAGATG CGTTCTCGGG 480 GCCCCAGGCC TGCACCCGTT TCTTCTCCCG CATCACGAAG GCCAATGTGG ACCTGCTCCC 540

GAGGGGGGCT CCCGAGCGAC AGCGGCTGCT GCCTGCGGCT CTGGCCTGCT GGGGTGTGCG 600

GGGGTCTCTG CTGAGCGAGG CTGATGTGCG GGCTCTGGGA GGCCTGGCTT GCGACCTGCC 660

TGGGCGCTTT GTGGCCGAGT CGGCCGAAGT GCTGCTACCC CGGCTGGTGA GCTGCCCGGG 720

ACCCCTGGAC CAGGACCAGC AGGAGGCAGC CAGGGCGGCT CTGCAGGGCG GGGGACCCCC 780 CTACGGCCCC CCGTCGACAT GGTCTGTCTC CACGATGGAC GCTCTGCGGG GCCTGCTGCC 840

CGTGCTGGGC CAGCCCATCA TCCGCAGCAT CCtGCAGGGC ATCGTGGCCG CGTGGCGGCA 900

ACGCTCCTCT CGGGACCCAT CCTGGCGGCA GCCTGAACGG ACCATCCTCC GGCCGCGGTT 960

CCGGCGGGAA GTGGAGAAGA CAGCCTGTCC TTCAGGCAAG AAGGCCCGCG AGATAGACGA 1020

GAGCCTCATC TTCTACAAGA AGTGGGAGCT GGAAGCCTGC GTGGATGCGG CCCTGCTGGC 1080 CACCCAGATG GACCGCGTGA ACGCCATCCC CTTCACCTAC GAGCAGCTGG ACGTCCTAAA 1140

GCATAAACTG GATGAGCTCT ACCCACAAGG TTACCCCGAG TCTGTGATCC AGCACCTGGG 1200

CTACCTCTTC CTCAAGATGA GCCCTGAGGA CATTCGCAAG TGGAATGTGA CGTCCCTGGA 1260

GACCCTGAAG GCTTTGCTTG AAGTCGACAA AGGGCACGAA ATGAGTCCTC AGGCTCCTCG 1320

GCGGCCCCTC CCACAGGTGG CCACCCTGAT CGACCGCTTT GTGAAGGGAA GGGGCCAGCT 1380 AGACAAAGAC ACCCTAGACA CCCTGACCGC CTTCTACCCT GGGTACCTGT GCTCCCTCAG 1440

CCCCGAGGAG CTGAGCTCCG TGCCCCCCAG CAGCATCTGG GCGGTCAGGC CCCAGGACCT 1500

GGACACGTGT GACCCAAGGC AGCTGGACGT CCTCTATCCC AAGGCCCGCC TTGCTTTCCA 1560

GAACATGAAC GGGTCCGAAT ACTTCGTGAA GATCCAGTCC TTCCTGGGTG GGGCCCCCAC 1620

GGAGGATTTG AAGGCGCTCA GTCAGCAGAA TGTGAGCATG GACTTGGCCA CGTTCATGAA 1680 GCTGCGGACG GATGCGGTGC TGCCGTTGAC TGTGGCTGAG GTGCAGAAAC TTCTGGGACC 1740

CCACGTGGAG GGCCTGAAGG CGGAGGAGCG GCACCGCCCG GTGCGGGACT GGATCCTACG 1800

GCAGCGGCAG GACGACCTGG ACACGCTGGG GCTGGGGCTA CAGGGCGGCA TCCCCAACGG 1860

CTACCTGGTC CTAGACCTCA GCGTGCAAGA GACCCTCTCG GGGACGCCCT GCCTCCTAGG 1920

ACCTGGACCT GTTCTCACCG TCCTGGCACT GCTCCTAGCC TCCACCCTGG CCTGAGGGCC 1980 CCACTCCCTT GCTGGCCCCA GCCCTGCTGG GGATCCCCGC CTGGCCAGGA GCAGGCACGG 2040

GTGATCCCCG TTCCACCCCA AGAGAACTCG CGCTCAGTAA ACGGGAACAT GCCCCCTGCA 2100 GACACGT

Seq ID NO: 38 Protein sequence Protein Accession ft: NP_037S36.1

1 11 21 31 41 51

I I I I I I

MALQRLDPC SCGDRPGSLL FLLFSLG VH PARTLAGETG TESAPLGGVL TTPHNISSLS 60

PRQLLGFPCA EVSGLSTERV RELAVALAQK NVKLSTEQLR CLAHRLSEPP EDLDALPLDL 120 LLFLNPDAFS GPQACTRFFS RITKANVDLL PRGAPERQRL LPAALACWGV RGSLLSEADV 180

RALGGLACDL PGRFVAESAE VLLPRLVSCP GPLDQDQQEA ARAALQGGGP PYGPPSTWSV 240

STMDALRGLL PVLGQPIIRS IPQGIVAA R QRSSRDPSWR QPERTILRPR FRREVEKTAC 300

PSGKKAREID ESLIFYKKWE LEACVDAALL ATQMDRVNAI PFTYEQLDVL KHKLDELYPQ 360

GYPESVIQHL GYLFLKMSPE DIRKWNVTSL ETLKALLEVD KGHEMSPQAP RRPLPQVATL 420 IDRFVKGRGQ LDKDTLDTLT AFYPGYLCSL SPEELSSVPP SSIWAVRPQD LDTCDPRQLD 480

VLYPKARLAF QNMNGSEYFV KIQSFLGGAP TEDLKALSQQ NVSMDLATFM KLRTDAVLPL 540

TVAEVQKLLG PHVEGLKAEE RHRPVRDWIL RQRQDDLDTL GLGLQGGIPN GYLVLDLSVQ 600 ETLSGTPCLL GPGPVLTVLA LLLASTLA Seq ID NO: 39 DNA sequence

Nucleic Acid Accession ft: NM_001508.1

Coding sequence: 1..1362

1 11 21 31 41 51

I I I I I I

ATGGCTTCAC CCAGCCTCCC GGGCAGTGAC TGCTCCCAAA TCATTGATCA CAGTCATGTC 60

CCCGAGTTTG AGGTGGCCAC CTGGATCAAA ATCACCCTTA TTCTGGTGTA CCTGATCATC 120

TTCGTGATGG GCCTTCTGGG GAACAGCGTC ACCATTCGGG TCACCCAGGT GCTGCAGAAG 180

AAAGGATACT TGCAGAAGGA GGTGACAGAC CACATGGTGA GTTTGGCTTG CTCGGACATC 240

TTGGTGTTCC TCATCGGCAT GCCCATGGAG TTCTACAGCA TCATCTGGAA TCCCCTGACC 300 ACGTCCAGCT ACACCCTGTC CTGCAAGCTG CACACTTTCC TCTTCGAGGC CTGCAGCTAC 360

GCTACGCTGC TGCACGTGCT GACGCTCAGC TTTGAGCGCT ACATCGCCAT CTGTCACCCC 420

TTCAGGTACA AGGCTGTGTC GGGACCTTGC CAGGTGAAGC TGCTGATTGG CTTCGTCTGG 480

GTCACCTCCG CCCTGGTGGC ACTGCCCTTG CTGTTTGCCA TGGGTACTGA GTACCCCCTG 540

GTGAACGTGC CCAGCCACCG GGGTCTCACT TGCAACCGCT CCAGCACCCG CCACCACGAG 600

CAGCCCGAGA CCTCCAATAT GTCCATCTGT ACCAACCTCT CCAGCCGCTG GACCGTGTTC 660

CAGTCCAGCA TCTTCGGCGC CTTCGTGGTC TACCTCGTGG TCCTGCTCTC CGTAGCCTTC 720

ATGTGCTGGA ACATGATGCA GGTGCTCATG AAAAGCCAGA AGGGCTCGCT GGCCGGGGGC 780

ACGCGGCCTC CGCAGCTGAG GAAGTCCGAG AGCGAAGAGA GCAGGACCGC CAGGAGGCAG 840

ACCATCATCT TCCTGAGGCT GATTGTTGTG ACATTGGCCG TATGCTGGAT GCCCAACCAG 900

ATTCGGAGGA TCATGGCTGC GGCCAAACCC AAGCACGACT GGACGAGGTC CTACTTCCGG 960 GCGTACATGA TCCTCCTCCC CTTCTCGGAG ACGTTTTTCT ACCTCAGCTC GGTCATCAAC 1020 CCGCTCCTGT ACACGGTQTC CTCGCAGCAG TTTCGGCGGG TGTTCGTGCA GGTGCTGTGC 1080 TGCCGCCTGT CGCTGCAGCA CGCCAACCAC GAGAAGCGCC TGCGCGTACA TGCGCACTCC 1140 ACCACCGACA GCGCCCGCTT TGTGCAGCGC CCGTTGCTCT TCGCGTCCCG GCGCCAGTCC 1200 TCTGCAAGGA GAACTGAGAA GATTTTCTTA AGCACTTTTC AGAGCGAGGC CGAGCCCCAG 1260 TCTAAGTCCC AGTCATTGAG TCTCGAGTCA CTAGAGCCCA ACTCAGGCGC GAAACCAGCC 1320 AATTCTGCTG CAGAGAATGG TTTTCAGGAG CATGAAGTTT GA

60

120

ATLLHVLTLS FERYIAICHP FRYKAVSGPC QVKLLIGFVW VTSALVALPL LFAMGTEYPL 180

VNVPSHRGLT CNRSSTRHHE QPETSNMSIC TNLSSRWTVF QSSIFGAFW YLWLLSVAF 240

MCNMMQVLM KSQKGSLAGG TRPPQLRKSE SEESRTARRQ TIIFLRLIW TLAVCMPNQ 300

IRRIMAAAKP KHDWTRSYFR AYMILLPFSE TFFYLSSVIN PLLYTVSSQQ FRRVFVQVLC 360

CRLSLQHANH EKRLRVHAHS TTDSARFVQR PLLFASRRQS SARRTEKIFL STFQSEAEPQ 420

SKSQSLSLES LEPNSGAKPA NSAAENGFQE HEV

Seq ID NO: 41 DNA sequence

Nucleic Acid Accession ft : NM_022358

Coding sequence : 65. .10S7

1 11 21 31 51 i i i

GGAGCGCGCG GTCCGGGCAC ACGGAGCAGG TTGGGACCGC GGCGGGTACC GGGGCCGGGG 60 CGCCATGCGG AGGCCGAGCG TGCGCGCGGC CGGGCTGGTC CTGTGCACCC TGTGTTACCT 120 GCTGGTGGGC GCTGCTGTCT TCGACGCGCT CGAGTCCGAG GCGGAAAGCG GCCGCCAGCG 180 ACTGCTGGTC CAGAAGCGGG GCGCTCTCCG GAGGAAGTTC GGCTTCTCGG CCGAGGACTA 240 CCGCGAGCTG GAGCGCCTGG CGCTCCAGGC TGAGCCCCAC CGCGCCGGCC GCCAGTGGAA 300 GTTCCCCGGC TCCTTCTACT TCGCCATCAC CGTCATCACT ACCATCGGGT ACGGCCACGC 360 CGCGCCGGGT ACGGACTCCG GCAAGGTCTT CTGCATGTTC TACGCGCTCC TGGGCATCCC 420 GCTGACGCTG GTCACTTTCC AGAGCCTGGG CGAACGGCTG AACGCGGTGG TGCGGCGCCT 480 CCTGTTGGCG GCCAAGTGCT GCCTGGGCCT GCGGTGGACG TGCGTGTCCA CGGAGAACCT 540 GGTGGTGGCC GGGCTGCTGG CGTGTGCCGC CACCCTGGCC CTCGGGGCCG TCGCCTTCTC 600 GCACTTCGAG GGCTGGACCT TCTTCCACGC CTACTACTAC TGCTTCATCA CCCTCACCAC 660 CATCGGCTTC GGCGACTTCG TGGCACTGCA GAGCGGCGAG GCGCTGCAGA GGAAGCTCCC 720 CTACGTGGCC TTCAGCTTCC TCTACATCCT CCTGGGGCTC ACGGTCATTG GCGCCTTCCT 780 CAACCTGGTG GTCCTGCGCT TCCTCGTTGC CAGCGCCGAC TGGCCCGAGC GCGCTGCCCG 840 CCCCCCCAGC CCGCGCCCCC CGGGGGCGCC CGAGAGCCGT GGCCTCTGGC TGCCCCGCCG 900 CCCGGCCCGC TCCGTGGGCT CCGCCTCTGT CTTCTGCCAC GTGCACAAGC TGGAGAGGTG 960 CGCCCGCGAC AACCTGGGCT TTTCGCCCCC CTCGAGCCCG GGGGTCGTGC GTGGCGGGCA 1020 GGCTCCCAGG CCTGGGGCCC GGTGGAAGTC CATCTGACAA CCCCACCCAG GCCAGGGTCG 1080 AATCTGGAAT GGGAGGGTCT GGCTTCAGCT ATCAGGGCAC CCTCCCCAGG GATTGGAAAC 1140 GGATGACGGG CCTCTAGGCG GTCTTCTGCC ACGAGCAGTT TCTCATTACT GTCTGTGGCT 1200 AAGTCCCCTC CCTCCTTTCC AAAAATATAT TACAGTCACA CCATAAAAAA AAAAAAAAAA 1260 AAAAAAAAAA AAAAAAAAAA AAAAAA

Seq ID NO: 42 Protein sequence Protein Accession ft: NP_071753 1 11 21 31 41 51

I I I I I I

MRRPSVRAAG LVLCTLCYLL VGAAVFDALE SEAESGRQRL LVQKRGALRR KFGFSAEDYR 60

ELERLALQAE PHRAGRQ KF PGSFYFAITV ITTIGYGHAA PGTDSGKVFC MFYALLGIPL 120

TLVTFQSLGE RLNAWRRLL LAAKCCLGLR WTCVSTENLV VAGLLACAAT LALGAVAFSH 180

FEGWTFFHAY YYCFITLTTI GFGDFVALQS GEALQRKLPY VAFSFLYILL GLTVIGAFLN 240

LWLRFLVAS AD PERAARP PSPRPPGAPE SRGLWLPRRP ARSVGSASVF CHVHKLERCA 300 RDNLGFSPPS SPGWRGGQA PRPGARWKSI

Seq ID NO: 43 DNA sequence

Nucleic Acid Accession ft: NM_000869.1

Coding sequence: 220..1656

1 11 21 31 41 51

I I

GGAAACATGA TCCAGCTGAA GGACTGATTG CAGGAAAACT TGGCAGCTCC CCAACCTTGG 60 TGGCCCAGGG AGTGTGAGGC TGCAGCCTCA GAAGGTGTGA GCAGTGGCCA CGAGAGGCAG 120 GCTGGCTGGG ACATGAGGTT GGCAGAGGGC AGGCAAGCTG GCCCTTGGTG GGCCTCGCCC 180 TGAGCACTCG GAGGCACTCC TATGCTTGGA AAGCTCGCTA TGCTGCTGTG GGTCCAGCAG 240 GCGCTGCTCG CCTTGCTCCT CCCCACACTC CTGGCACAGG GAGAAGCCAG GAGGAGCCGA 300 AACACCACCA GGCCCGCTCT GCTGAGGCTG TCGGATTACC TTTTGACCAA CTACAGGAAG 360 GGTGTGCGCC CCGTGAGGGA CTGGAGGAAG CCAACCACCG TATCCATTGA CGTCATTGTC 420 TATGCCATCC TCAACGTGGA TGAGAAGAAT CAGGTGCTGA CCACCTACAT CTGGTACCGG 480 CAGTACTGGA CTGATGAGTT TCTCCAGTGG AACCCTGAGG ACTTTGACAA CATCACCAAG 540 TTGTCCATCC CCACGGACAG CATCTGGGTC CCGGACATTC TCATCAATGA GTTCGTGGAT 600 GTGGGGAAGT CTCCAAATAT CCCGTACGTG TATATTCGGC ATCAAGGCGA AGTTCAGAAC 660 TACAAGCCCC TTCAGGTGGT GACTGCCTGT AGCCTCGACA TCTACAACTT CCCCTTCGAT 720 GTCCAGAACT GCTCGCTGAC CTTCACCAGT TGGCTGCACA CCATCCAGGA CATCAACATC 780 TCTTTGTGGC GCTTGCCAGA AAAGGTGAAA TCCGACAGGA GTGTCTTCAT GAACCAGGGA 840 GAGTGGGAGT TGCTGGGGGT GCTGCCCTAC TTTCGGGAGT TCAGCATGGA AAGCAGTAAC 900 TACTATGCAG AAATGAAGTT CTATGTGGTC ATCCGCCGGC GGCCCCTCTT CTATGTGGTC 960 AGCCTGCTAC TGCCCAGCAT CTTCCTCATG GTCATGGACA TCGTGGGCTT CTACCTGCCC 1020 CCCAACAGTG GCGAGAGGGT CTCTTTCAAG ATTACACTCC TCCTGGGCTA CTCGGTCTTC 1080 CTGATCATCG TTTCTGACAC GCTGCCGGCC ACTGCCATCG GCACTCCTCT CATTGGTGTC 1140 TACTTTGTGG TGTGCATGGC TCTGCTGGTG ATAAGTTTGG CCGAGACCAT CTTCATTGTG 1200 CGGCTGGTGC ACAAGCAAGA CCTGCAGCAG CCCGTGCCTG CTTGGCTGCG TCACCTGGTT 1260 CTGGAGAGAA TCGCCTGGCT ACTTTGCCTG AGGGAGCAGT CAACTTCCCA GAGGCCCCCA 1320 GCCACCTCCC AAGCCACCAA GACTGATGAC TGCTCAGCCA TGGGAAACCA CTGCAGCCAC 1380 ATGGGAGGAC CCCAGGACTT CGAGAAGAGC CCGAGGGACA GATGTAGCCC TCCCCCACCA 1440 CCTCGGGAGG CCTCGCTGGC GGTGTGTGGG CTGCTGCAGG AGCTGTCCTC CATCCGGCAA 1500 TTCCTGGAAA AGCGGGATGA GATCCGAGAG GTGGCCCGAG ACTGGCTGCG CGTGGGCTCC 1560 GTGCTGGACA AGCTGCTATT CCACATTTAC CTGCTAGCGG TGCTGGCCTA CAGCATCACC 1620 CTGGTTATGC TCTGGTCCAT CTGGCAGTAC GCTTGAGTGG GTACAGCCCA GTGGAGGAGG 1680 GGGTACAGTC CTGGTTAGGT GGGGACAGAG GATTTCTGCT TAGGCCCCTC AGGACCCAGG 1740 GAATGCCAGG GACATTTTCA AGACACAGAC AAAGTCCCGT GCCCTGTTTC CAATGCCAAT 1800 TCATCTCAGC AATCACAAGC CAAGGTCTGA ACCCTTCCAC CAAAAACTGG GTGTTCAAGG 1860 CCCTTACACC CTTGTCCCAC CCCCAGCAGC TCACCATGGC TTTAAAACAT GCTCTCTTAG 1920 ATCAGGAGAA ACTCGGGCAC TCCCTAAGTC CACTCTAGTT GTGGACTTTT CCCCATTGAC 1980 CCTCACCTGA ATAAGGGACT TTGGAATTCT GCTTCTCTTT CACAACTTTG CTTTTAGGTT 2040 GAAGGCAAAA CCAACTCTCT ACTACACAGG CCTGATAACT CTGTACGAGG CTTCTCTAAC 2100 CCCTAGTGTC TTTTTTTTCT TCACCTCACT TGTGGCAGCT TCCCTGAACA CTCATCCCCC 2160 ATCAGATGAT GGGAGTGGGA AGAATAAAAT GCAGTGAAAC CC

Seq ID NO: 44 Protein sequence Protein Accession ft: NP_000860.1

1 11 21 31 41 51

MLLWVQQALL ALLLPTLLAQ GEARRSRNTT RPALLRLSDY LLTNYRKGVR PVRDWRKPTT 60 VSIDVIVYAI LNVDEKNQVL TTYIHYRQYW TDEFLQWNPE DFDNITKLSI PTDSIWVPDI 120 LINEFVDVGK SPNIPYVYIR HQGEVQNYKP LQWTACSLD IYNFPFDVQN CSLTFTSWLH 180 TIQDINISLW RLPEKVKSDR SVFMNQGEWE L.GVLPYFRE FSMESSNYYA EMKFYWIRR 240 RPLFYWSLL LPSIFLMVMD IVGFYLPPNS GERVSFKITL LLGYSVFLII VSDTLPATAI 300 GTPLIGVYFV VCMALLVISL AETIFIVRLV HKQDLQQPVP AWLRHLVLER IAWLLCLREQ 360 STSQRPPATS QATKTDDCSA MGNHCSHMGG PQDFEKSPRD RCSPPPPPRE ASLAVCGLLQ 420 ELSSIRQFLE KRDEIREVAR D LRVGSVLD KLLFHIYLLA VLAYSITLVM LWSIWQYA

Seq ID NO: 45 DNA sequence

Nucleic Acid Accession ft: NM_015507

Coding sequence: 241..1902

1 11 21 31 51

I I I I

CCGCAGAGGA GCCTCGGCCA GGCTAGCCAG GGCGCCCCCA GCCCCTCCCC AGGCCGCGAG 60 CGCCCCTGCC GCGGTGCCTG GCCTCCCCTC CCAGACTGCA GGGACAGCAC CCGGTAACTG 120 CGAGTGGAGC GGAGGACCCG AGCGGCTGAG GAGAGAGGAG GCGGCGGCTT AGCTGCTACG 180 GGGTCCGGCC GGCGCCCTCC CGAGGGGGGC TCAGGAGGAG GAAGGAGGAC CCGTGCGAGA 240 ATGCCTCTGC CCTGGAGCCT TGCGCTCCCG CTGCTGCTCT CCTGGGTGGC AGGTGGTTTC 300 GGGAACGCGG CCAGTGCAAG GCATCACGGG TTGTTAGCAT CGGCACGTCA GCCTGGGGTC 360 TGTCACTATG GAACTAAACT GGCCTGCTGC TACGGCTGGA GAAGAAACAG CAAGGGAGTC 420 TGTGAAGCTA CATGCGAACC TGGATGTAAG TTTGGTGAGT GCGTGGGACC AAACAAATGC 480 AGATGCTTTC CAGGATACAC CGGGAAAACC TGCAGTCAAG ATGTGAATGA GTGTGGAATG 540 AAACCCCGGC CATGCCAACA CAGATGTGTG AATACACACG GAAGCTACAA GTGCTTTTGC 600 CTCAGTGGCC ACATGCTCAT GCCAGATGCT ACGTGTGTGA ACTCTAGGAC ATGTGCCATG 660 ATAAACTGTC AGTACAGCTG TGAAGACACA GAAGAAGGGC CACAGTGCCT GTGTCCATCC 720 TCAGGACTCC GCCTGGCCCC AAATGGAAGA GACTGTCTAG ATATTGATGA ATGTGCCTCT 780 GGTAAAGTCA TCTGTCCCTA CAATCGAAGA TGTGTGAACA CATTTGGAAG CTACTACTGC 840 AAATGTCACA TTGGTTTCGA ACTGCAATAT ATCAGTGGAC GATATGACTG TATAGATATA 900 AATGAATGTA CTATGGATAG CCATACGTGC AGCCACCATG CCAATTGCTT CAATACCCAA 960 GGGTCCTTCA AGTGTAAATG CAAGCAGGGA TATAAAGGCA ATGGACTTCG GTGTTCTGCT 1020 ATCCCTGAAA ATTCTGTGAA GGAAGTCCTC AGAGCACCTG GTACCATCAA AGACAGAATC 1080 AAGAAGTTGC TTGCTCACAA AAACAGCATG AAAAAGAAGG CAAAAATTAA AAATGTTACC 1140 CCAGAACCCA CCAGGACTCC TACCCCTAAG GTGAACTTGC AGCCCTTCAA CTATGAAGAG 1200 ATAGTTTCCA GAGGCGGGAA CTCTCATGGA GGTAAAAAAG GGAATGAAGA GAAAATGAAA 1260 GAGGGGCTTG AGGATGAGAA AAGAGAAGAG AAAGCCCTGA AGAATGACAT AGAGGAGCGA 1320 AGCCTGCGAG GAGATGTGTT TTTCCCTAAG GTGAATGAAG CAGGTGAATT CGGCCTGATT 1380 CTGGTCCAAA GGAAAGCGCT AACTTCCAAA CTGGAACATA AAGATTTAAA TATCTCGGTT 1440 GACTGCAGCT TCAATCATGG GATCTGTGAC TGGAAACAGG ATAGAGAAGA TGATTTTGAC 1500 TGGAATCCTG CTGATCGAGA TAATGCTATT GGCTTCTATA TGGCAGTTCC GGCCTTGGCA 1560 GGTCACAAGA AAGACATTGG CCGATTGAAA CTTCTCCTAC CTGACCTGCA ACCCCAAAGC 1620 AACTTCTGTT TGCTCTTTGA TTACCGGCTG GCCGGAGACA AAGTCGGGAA ACTTCGAGTG 1680 TTTGTGAAAA ACAGTAACAA TGCCCTGGCA TGGGAGAAGA CCACGAGTGA GGATGAAAAG 1740 TGGAAGACAG GGAAAATTCA GTTGTATCAA GGAACTGATG CTACCAAAAG CATCATTTTT 1800 GAAGCAGAAC GTGGCAAGGG CAAAACCGGC GAAATCGCAG TGGATGGCGT CTTGCTTGTT 1860 TCAGGCTTAT GTCCAGATAG CCTTTTATCT GTGGATGACT GAATGTTACT ATCTTTATAT 1920 TTGACTTTGT ATGTCAGTTC CCTGGTTTTT TTGATATTGC ATCATAGGAC CTCTGGCATT 1980 TTAGAATTAC TAGCTGAAAA ATTGTAATGT ACCAACAGAA ATATTATTGT AAGATGCCTT 2040 TCTTGTATAA GATATGCCAA TATTTGCTTT AAATATCATA TCACTGTATC TTCTCAGTCA 2100 TTTCTGAATC TTTCCACATT ATATTATAAA ATATGGAAAT GTCAGTTTAT CTCCCCTCCT 2160 CAGTATATCT GATTTGTATA AGTAAGTTGA TGAGCTTCTC TCTACAACAT TTCTAGAAAA 2220 TAGAAAAAAA AGCACAGAGA AATGTTTAAC TGTTTGACTC TTATGATACT TCTTGGAAAC 2280 TATGACATCA AAGATAGACT TTTGCCTAAG TGGCTTAGCT GGGTCTTTCA TAGCCAAACT 2340 TGTATATTTA AATTCTTTGT AATAATAATA TCCAAATCAT CAAAAAAAAA AAAAAAAA

Seq ID NO: 46 Protein sequence Protein Accession #: NP_056322 1 11 21 31 41 51

I I I I I I

MPLPWSLALP LLLSWVAGGF GNAASARHHG LLASARQPGV CHYGTKLACC YGWRRNSKGV 60

CEATCEPGCK FGECVGPNKC RCFPGYTGKT CSQDVNECGM KPRPCQHRCV NTHGSYKCFC 120

LSGHMLMPDA TCVNSRTCAM INCQYSCEDT EEGPQCLCPS SGLRLAPNGR DCLDIDECAS 180

GKVICPYNRR CVNTFGSYYC KCHIGFELQY ISGRYDCIDI NECTMDSHTC SHHANCFNTQ 240 GSFKCKCKQG YKGNGLRCSA IPENSVKEVL RAPGTIKDRI KKLLAHKNSM KKKAKIKNVT 300

PEPTRTPTPK VNLQPFNYEE IVSRGGNSHG GKKGNEEKMK EGLEDEKREE KALKNDIEER 360

SLRGDVFFPK VNEAGEFGLI LVQRKALTSK LEHKDLNISV DCSFNHGICD WKQDREDDFD 420

HNPADRDNAI GFYMAVPALA GHKKDIGRLK LLLPDLQPQS NFCLLFDYRL AGDKVGKLRV 480 FVKNSNNALA WEKTTSEDEK WKTGKIQLYQ GTDATKSIIF EAERGKGKTG EIAVDGVLLV 540 SGLCPDSLLS VDD

Seq ID NO: 47 DNA sequence Nucleic Acid Accession ft: NM_005046 Coding sequence: 16..777

1 11 21 31 41 51

GGATTTCCGG GCTCCATGGC AAGATCCCTT CTCCTGCCCC TGCAGATCCT ACTGCTATCC 60

TTAGCCTTGG AAACTGCAGG AGAAGAAGCC CAGGGTGACA AGATTATTGA TGGCGCCCCA 120

TGTGCAAGAG GCTCCCACCC ATGGCAGGTG GCCCTGCTCA GTGGCAATCA GCTCCACTGC 180

GGAGGCGTCC TGGTCAATGA GCGCTGGGTG CTCACTGCCG CCCACTGCAA GATGAATGAG 240

TACACCGTGC ACCTGGGCAG TGATACGCTG GGCGACAGGA GAGCTCAGAG GATCAAGGCC 300

TCGAAGTCAT TCCGCCACCC CGGCTACTCC ACACAGACCC ATGTTAATGA CCTCATGCTC 360

GTGAAGCTCA ATAGCCAGGC CAGGCTGTCA TCCATGGTGA AGAAAGTCAG GCTGCCCTCC 420

CGCTGCGAAC CCCCTGGAAC CACCTGTACT GTCTCCGGCT GGGGCACTAC CACGAGCCCA 480

GATGTGACCT TTCCCTCTGA CCTCATGTGC GTGGATGTCA AGCTCATCTC CCCCCAGGAC 540

TGCACGAAGG TTTACAAGGA CTTACTGGAA AATTCCATGC TGTGCGCTGG CATCCCCGAC 600

TCCAAGAAAA ACGCCTGCAA TGGTGACTCA GGGGGACCGT TGGTGTGCAG AGGTACCCTG 660

CAAGGTCTGG TGTCCTGGGG AACTTTCCCT TGCGGCCAAC CCAATGACCC AGGAGTCTAC 720

ACTCAAGTGT GCAAGTTCAC CAAGTGGATA AATGACACCA TGAAAAAGCA TCGCTAACGC 780

CACACTGAGT TAATTAACTG TGTGCTTCCA A.AGAAAATG CACAGGAGTG AGGACGCCGA 840

TGACCTATGA AGTCAAATTT GACTTTACCT TTCCTCAAAG ATATATTTAA ACCTCATGCC 900

CTGTTGATAA ACCAATCAAA TTGGTAAAGA CCTAAAACCA AAACAAATAA AGAAACACAA 960 AACCCTCAA

Seq ID NO: 48 Protein sequence Protein Accession #: NP_005037 1 11 21 31 41 51

I I I I I I

MARSLLLPLQ ILLLSLALET AGEEAQGDKI IDGAPCARGS HPWQVALLSG NQLHCGGVLV 60

NERWVLTAAH CKMNEYTVHL GSDTLGDRRA QRIKASKSFR HPGYSTQTHV NDLMLVKLNS 120

QARLSS VKK VRLPSRCEPP GTTCTVSGWG TTTSPDVTFP SDLMCVDVKL ISPQDCTKVY 180

KDLLENSMLC AGIPDSKKNA CNGDSGGPLV CRGTLQGLVS GTFPCGQPN DPGVYTQVCK 240 FTKWINDTMK KHR

Seq ID NO: 49 DNA sequence

Nucleic Acid Accession ft: NM_003466.1

Coding sequence: 11..1363

1 11 21 31 41 51

I I I I I I

GAATTCGGCG ATGCCTCACA ACTCCATCAG ATCTGGCCAT GGAGGGCTGA ACCAGCTGGG 60

AGGGGCCTTT GTGAATGGCA GACCTCTGCC GGAAGTGGTC CGCCAGCGCA TCGTAGACCT 120

GGCCCACCAG GGTGTAAGGC CCTGCGACAT CTCTCGCCAG CTCCGCGTCA GCCATGGTTG 180

CGTCAGCAAG ATCCTTGGCA GGTACTACGA GACTGGCAGC ATCCGGCCTG GAGTGATAGG 240

GGGCTCCAAG CCCAAGGTGG CCACCCCCAA GGTGGTGGAG AAGATTGGGG ACTACAAACG 300

CCAGAACCCT ACCATGTTTG CCTGGGAGAT CCGAGACCGG CTCCTGGCTG AGGGCGTCTG 360

TGACAATGAC ACTGTGCCCA GTGTCAGCTC CATTAATAGA ATCATCCGGA CCAAAGTGCA 420

GCAACCATTC AACCTCCCTA TGGACAGCTG CGTGGCCACC AAGTCCCTGA GTCCCGGACA 480

CACGCTGATC CCCAGCTCAG CTGTAACTCC CCCGGAGTCA CCCCAGTCGG ATTCCCTGGG 540

CTCCACCTAC TCCATCAATG GGCTCCTGGG CATCGCTCAG CCTGGCAGCG ACAAGAGGAA 600

AATGGATGAC AGTGATCAGG ATAGCTGCCG ACTAAGCATT GACTCACAGA GCAGCAGCAG 660

CGGACCCCGA AAGCACCTTC GCACGGATGC CTTCAGCCAG CACCACCTCG AGCCGCTCGA 720

GTGCCCATTT GAGCGGCAGC ACTACCCAGA GGCCTATGCC TCCCCCAGCC ACACCAAAGG 780

CGAGCAGGGC CTCTACCCGC TGCCCTTGCT CAACAGCACC CTGGACGACG GGAAGGCCAC 840

CCTGACCCCT TCCAACACGC CACTGGGGCG CAACCTCTCG ACTCACCAGA CCTACCCCGT 900

GGTGGCAGAT CCTCACTCAC CCTTCGCCAT AAAGCAGGAA ACCCCCGAGG TGTCCAGTTC 960

TAGCTCCACC CCTTCCTCTT TATCTAGCTC CGCCTTTTTG GATCTGCAGC AAGTCGGCTC 1020

CGGGGTCCCG CCCTTCAATG CCTTTCCCCA TGCTGCCTCC GTGTACGGGC AGTTCACGGG 1080

CCAGGCCCTC CTCTCAGGGC GAGAGATGGT GGGGCCCACG CTGCCCGGAT ACCCACCCCA 1140

CATCCCCACC AGCGGACAGG GCAGCTATGC CTCCTCTGCC ATCGCAGGCA TGGTGGCAGG 1200

AAGTGAATAC TCTGGCAATG CCTATGGCCA CACCCCCTAC TCCTCCTACA GCGAGGCCTG 1260

GCGCTTCCCC AACTCCAGCT TGCTGAGTTC CCCATATTAT TACAGTTCCA CATCAAGGCC 1320 GAGTGCACCG CCCACCACTG CCACGGCCTT TGACCATCTG TAGTTGAAGC TT

Seq ID NO: SO Protein sequence Protein Accession ft: NP_003457 1 11 21 31 41 51

I I I I I I

MPHNSIRSGH GGLNQLGGAF VNGRPLPEW RQRIVDLAHQ GVRPCDISRQ LRVSHGCVSK 60

ILGRYYETGS 1RPGVIGGSK PKVATPKWE KIGDYKRQNP TMFAWEIRDR LLAEGVCDND 120

TVPSVSSINR IIRTKVQQPF NLPMDSCVAT KSLSPGHTLI PSSAVTPPES PQSDSLGSTY 180

SINGLLGIAQ PGSDKRKMDD SDQDSCRLSI DSQSSSSGPR KHLRTDAFSQ HHLEPLECPF 240

ERQHYPEAYA SPSHTKGEQG LYPLPLLNST LDDGKATLTP SNTPLGRNLS THQTYPWAD 300

PHSPFAIKQE TPEVSSSSST PSSLSSSAFL DLQQVGSGVP PFNAFPHAAS VYGQFTGQAL 360

LSGREMVGPT LPGYPPHIPT SGQGSYASSA IAGMVAGSEY SGNAYGHTPY SSYSEAWRFP 420 NSSLLSSPYY YSSTSRPSAP PTTATAFDHL

Seq ID NO: 51 DNA sequence

Nucleic Acid Accession ft: NM_013952

Coding sequence: 161..1357. 11 21 31 41 51

I I I

TTCAGAAGGA I

GGAGAGACAC CGGGCCCAGG GCACCCTCGC GGGCGGGCGG ACCCAAGCAG 60 TGAGGGCCTG CAGCCGGCCG GCCAGGGCAG CGGCAGGCGC GGCCCGGACC TACGGGAGGA 120 AGCCCCGAGC CCTCGGCGGG CTGCGAGCGA CTCCCCGGCG ATGCCTCACA ACTCCATCAG 180 ATCTGGCCAT GGAGGGCTGA ACCAGCTGGG AGGGGCCTTT GTGAATGGCA GACCTCTGCC 240 GGAAGTGGTC CGCCAGCGCA TCGTAGACCT GGCCCACCAG GGTGTAAGGC CCTGCGACAT 300 CTCTCGCCAG CTCCGCGTCA GCCATGGCTG CGTCAGCAAG ATCCTTGGCA GGTACTACGA 360 GACTGGCAGC ATCCGGCCTG GAGTGATAGG GGGCTCCAAG CCCAAGGTGG CCACCCCCAA 420 GGTGGTGGAG AAGATTGGGG ACTACAAACG CCAGAACCCT ACCATGTTTG CCTGGGAGAT 480 CCGAGACCGG CTCCTGGCTG AGGGCGTCTG TGACAATGAC ACTGTGCCCA GTGTCAGCTC 540 CATTAATAGA ATCATCCGGA CCAAAGTGCA GCAACCATTC AACCTCCCTA TGGACAGCTG 600 CGTGGCCACC AAGTCCCTGA GTCCCGGACA CACGCTGATC CCCAGCTCAG CTGTAACTCC 660 CCCGGAGTCA CCCCAGTCGG ATTCCCTGGG CTCCACCTAC TCCATCAATG GGCTCCTGGG 720 CATCGCTCAG CCTGGCAGCG ACAAGAGGAA AATGGATGAC AGTGATCAGG ATAGCTGCCG 780 ACTAAGCATT GACTCACAGA GCAGCAGCAG CGGACCCCGA AAGCACCTTC GCACGGATGC 840 CTTCAGCCAG CACCACCTCG AGCCGCTCGA GTGCCCATTT GAGCGGCAGC ACTACCCAGA 900 GGCCTATGCC TCCCCCAGCC ACACCAAAGG CGAGCAGGGC CTCTACCCGC TGCCCTTGCT 960 CAACAGCACC CTGGACGACG GGAAGGCCAC CCTGACCCCT TCCAACACGC CACTGGGGCG 1020 CAACCTCTCG ACTCACCAGA CCTACCCCGT GGTGGCAGCT CCGCCCTTTT GGATCTGCAG 1080 CAAGTCGGCT CCGGGGTCCC GCCCTTCAAT GCCTTTCCCC ATGCTGCCTC CGTGTACGGG 1140 CAGTTCACGG GCCAGGCCCT CCTCTCAGGG CGAGAGATGG TGGGGCCCAC GCTGCCCGGA 1200 TACCCACCCC ACATCCCCAC CAGCGGACAG GGCAGCTATG CCTCCTCTGC CATCGCAGGC 1260 ATGGTGGCAG GAAGTGAATA CTCTGGCAAT GCCTATGGCC ACACCCCCTA CTCCTCCTAC 1320 AGCGAGGCCT GGGGCTTCCC CAACTCCAGC TTGCTGAGTT CCCCATATTA TTACAGTTCC 1380 ACATCAAGGC CGAGTGCACC GCCCACCACT G.CACGGCCT TTGACCATCT GTAGTTGCCA 1440 TGGGGACAGT G

Seq ID NO: 52 Protein sequence Protein Accession ft: NP_039246

1 11 21 31 41 51

I I I I I I

MPHNSIRSGH GGLNQLGGAF VNGRPLPEW RQRIVDLAHQ GVRPCDISRQ LRVSHGCVSK 60 ILGRYYETGS IRPGVIGGSK PKVATPKWE KIGDYKRQNP TMFA EIRDR LLAEGVCDND 120 TVPSVSSINR IIRTKVQQPF NLPMDSCVAT KSLSPGHTLI PSSAVTPPES PQSDSLGSTY 180 SINGLLGIAQ PGSDKRKMDD SDQDSCRLSI DSQSSSSGPR KHLRTDAFSQ HHLEPLECPF 240 ERQHYPEAYA SPSHTKGEQG LYPLPLLNST LDDGKATLTP SNTPLGRNLS THQTYPWAA 300 PPF ICSKSA PGSRPSMPFP MLPPCTGSSR ARPSSQGER WGPRCPDTHP TSPPADRAAM 360 PPLPSQAWWQ EVNTLAMPMA TPPTPPTARP GASPTPAC

Seq ID NO: 53 DNA sequence

Nucleic Acid Accession ft: NM_012427

Coding sequence: 43..9 4

1 11 21 31

I I I I

CTTGTGGTTC CTCTCTACTT GGGGAAATCA GGTGCAGCGG CCATGGCTAC AGCAAGACCC 60 CCCTGGATGT GGGTGCTCTG TGCTCTGATC ACAGCCTTGC TTCTGGGGGT CACAGAGCAT 120 GTTCTCGCCA ACAATGATGT TTCCTGTGAC CACCCCTCTA ACACCGTGCC CTCTGGGAGC 180 AACCAGGACC TGGGAGCTGG GGCCGGGGAA GACGCCCGGT CGGATGACAG CAGCAGCCGC 240 ATCATCAATG GATCCGACTG CGATATGCAC ACCCAGCCGT GGCAGGCCGC GCTGTTGCTA 300 AGGCCCAACC AGCTCTACTG CGGGGCGGTG TTGGTGCATC CACAGTGGCT GCTCACGGCC 360 GCCCACTGCA GGAAGAAAGT TTTCAGAGTC CGTCTCGGCC ACTACTCCCT GTCACCAGTT 420 TATGAATCTG GGCAGCAGAT GTTCCAGGGG GTCAAATCCA TCCCCCACCC TGGCTACTCC 480 CACCCTGGCC ACTCTAACGA CCTCATGCTC ATCAAACTGA ACAGAAGAAT TCGTCCCACT 540 AAAGATGTCA GACCCATCAA CGTCTCCTCT CATTGTCCCT CTGCTGGGAC AAAGTGCTTG 600 GTGTCTGGCT GGGGGACAAC CAAGAGCCCC CAAGTGCACT TCCCTAAGGT CCTCCAGTGC 660 TTGAATATCA GCGTGCTAAG TCAGAAAAGG TGCGAGGATG CTTACCCGAG ACAGATAGAT 720 GACACCATGT TCTGCGCCGG TGACAAAGCA GGTAGAGACT CCTGCCAGGG TGATTCTGGG 780 GGGCCTGTGG TCTGCAATGG CTCCCTGCAG GGACTCGTGT CCTGGGGAGA TTACCCTTGT 840 GCCCGGCCCA ACAGACCGGG TGTCTACACG AACCTCTGCA AGTTCACCAA GTGGATCCAG 900 GAAACCATCC AGGCCAACTC CTGAGTCATC CCAGGACTCA GCACACCGGC ATCCCCACCT 960 GCTGCAGGGA CAGCCCTGAC ACTCCTTTCA GACCCTCATT CCTTCCCAGA GATGTTGAGA 1020 ATGTTCATCT CTCCAGCCCC TGACCCCATG TCTCCTGGAC TCAGGGTCTG CTTCCCCCAC 1080 ATTGGGCTGA CCGTGTCTCT CTAGTTGAAC CCTGGGAACA ATTTCCAAAA CTGTCCAGGG 1140 CGGGGGTTGC GTCTCAATCT CCCTGGGGCA CTTTCATCCT CAAGCTCAGG GCCCATCCCT 1200 TCTCTGCAGC TCTGACCCAA ATTTAGTCCC AGAAATAAAC TGAGAAGTGG AAAAAAAAAA

Seq ID NO: 54 Protein sequence Protein Accession #: NP_036S59

1 11 21 31 41 51

I I I I

MATARPPWMW VLCALITALL LGVTEHVLAN NDVSCDHPSN TVPSGSNQDL GAGAGEDARS 60

DDSSSRIING SDCDMHTQPW QAALLLRPNQ LYCGAVLVHP QWLLTAAHCR KKVFRVRLGH 120

YSLSPVYESG QQMFQGVKSI PHPGYSHPGH SNDLMLIKLN RRIRPTKDVR PINVSSHCPS 180

AGTKCLVSGW GTTKSPQVHF PKVLQCLNIS VLSQKRCEDA YPRQIDDTMF CAGDKAGRDS 240

CQGDSGGPW CNGSLQGLVS WGDYPCARPN RPGVYTNLCK FTKWIQETIQ ANS

Seq ID NO: 55 DNA sequence

Nucleic Acid Accession #: NM_002214

Coding sequence: 681..2990

1 11 21 31 41 51

I I I I I I

CCCAGAGCCG CCTCCCCCTG TTGCTGGCAT CCCGAGCTTC CTCCCTTGCC AGCCAGGACG 60 CTGCCGACTT GTCTTTGCCC GCTGCTCCGC AGACGGGGCT GCAAAGCTGC AACTAATGGT 120 GTTGGCCTCC CTGCCCACCT GTGGAAGCAA CTGCGCTGAT TGATGCGCCA CAGACTTTTT 180 TCCCCTCGAC CTCGCCGGCG TACCCTCCCA CAGATCCAGC ATCACCCAGT GAATGTACAT 240 TAGGGTGGTT TCCCCCCCAG CTTCGGGCTT TGTTTGGGTT TGATTGTGTT TGGCTCTTCG 300 CTAAGCTGAT TTATGCAGCA GAAGCCCCAC CGGCTGGAGA GAAACAAAAG CTCTTTTCTT 360 TGTCCCGGAG CAGGCTGCGG AGCCCTTGCA GAGCCCTCTC TCCAGTCGCC GCCGGGCCCT 420 TGGCCGTCGA AGGAGGTGCT TCTCGCGGAG ACCGCGGGAC CCGCCGTGCC GAGCCGGGAG 480 GGCCGTAGGG GCCCTGAGAT GCCGAGCGGT GCCCGGGCCC GCTTACCTGC ACCGCTTGCT 540 CCGAGCCGCG GGGTCCGCCT GCTAGGCCTG CGGAAAACGT CCTAGCGACA CTCGCCCGCG 600 GGCCCCGAGG TCGCCCGGGA GGCCGAGCCC GCGTCCGGAA GGCAGCCAGG CGGCGGGCGC 660 GGGGCGGGCT GTTTTGCATT ATGTGCGGCT CGGCCCTGGC TTTTTTTACC GCTGCATTTG 720 TCTGCCTGCA AAACGACCGG CGAGGTCCCG CCTCGTTCCT CTGGGCAGCC TGGGTGTTTT 780 CACTTGTTCT TGGACTGGGC CAAGGTGAAG ACAATAGATG TGCATCTTCA AATGCAGCAT 840 CCTGTGCCAG GTGCCTTGCG CTGGGTCCAG AATGTGGATG GTGTGTTCAA GAGGATTTCA 900 TTTCAGGTGG ATCAAGAAGT GAACGTTGTG ATATTGTTTC CAATTTAATA AGCAAAGGCT 960 GCTCAGTTGA TTCAATAGAA TACCCATCTG TGCATGTTAT AATACCCACT GAAAATGAAA 1020 TTAATACCCA GGTGACACCA GGAGAAGTGT CTATCCAGCT GCGTCCAGGA GCCGAAGCTA 1080 ATTTTATGCT GAAAGTTCAT CCTCTGAAGA AATATCCTGT GGATCTTTAT TATCTTGTTG 1140 ATGTCTCAGC ATCAATGCAC AATAATATAG AAAAATTAAA TTCCGTTGGA AACGATTTAT 1200 CTAGAAAAAT GGCATTTTTC TCCCGTGACT TTCGTCTTGG ATTTGGCTCA TACGTTGATA 1260 AAACAGTTTC ACCATACATT AGCATCCACC CCGAAAGGAT TCATAATCAA TGCAGTGACT 1320 ACAATTTAGA CTGCATGCCT CCCCATGGAT ACATCCATGT GCTGTCTTTG ACAGAGAACA 1380 TCACTGAGTT TGAGAAAGCA GTTCATAGAC AGAAGATCTC TGGAAACATA GATACACCAG 1440 AAGGAGGTTT TGACGCCATG CTTCAGGCAG CTGTCTGTGA AAGTCATATC GGATGGCGAA 1500 AAGAGGCTAA AAGATTGCTG CTGGTGATGA CAGATCAGAC GTCTCATCTC GCTCTTGATA 1560 GCAAATTGGC AGGCATAGTG GTGCCCAATG ACGGAAACTG TCATCTGAAA AACAACGTCT 1620 ACGTCAAATC GACAACCATG GAACACCCCT CACTAGGCCA ACTTTCAGAG AAATTAATAG 1680 ACAACAACAT TAATGTCATC TTTGCAGTTC A GGAAAACA ATTTCATTGG TATAAGGATC 1740 TTCTACCCCT CTTGCCAGGC ACCATTGCTG GTGAAATAGA ATCAAAGGCT GCAAACCTCA 1800 ATAATTTGGT AGTGGAAGCC TATCAGAAGC TCATTTCAGA AGTGAAAGTT CAGGTGGAAA 1860 ACCAGGTACA AGGCATCTAT TTTAACATTA CCGCCATCTG TCCAGATGGG TCCAGAAAGC 1920 CAGGCATGGA AGGATGCAGA AACGTGACGA GCAATGATGA AGTTCTTTTC AATGTAACAG 1980 TTACAATGAA AAAATGTGAT GTCACAGGAG GAAAAAACTA TGCAATAATC AAACCTATTG 2040 GTTTTAATGA AACCGCTAAA ATTCATATAC ACAGAAACTG CAGCTGTCAG TGTGAGGACA 2100 ACAGAGGACC TAAAGGAAAG TGTGTAGATG AAACTTTTCT AGATTCCAAG TGTTTCCAGT 2160 GTGATGAGAA TAAATGTCAT TTTGATGAAG ATCAGTTTTC TTCTGAGAGT TGCAAGTCAC 2220 ACAAGGATCA GCCTGTTTGC AGTGGTCGAG GAGTTTGTGT TTGTGGGAAA TGTTCATGTC 2280 ACAAAATTAA GCTTGGAAAA GTGTATGGAA AATACTGTGA AAAGGATGAC TTTTCTTGTC 2340 CATATCACCA TGGAAATCTG TGTGCTGGGC ATGGAGAGTG TGAAGCAGGC AGATGCCAAT 2400 GCTTCAGTGG CTGGGAAGGT GATCGATGCC AGTGCCCTTC AGCAGCAGCC CAGCACTGTG 2460 TCAATTCAAA GGGCCAAGTG TGCAGTGGAA GAGGCACGTG TGTGTGTGGA AGGTGTGAGT 2520 GCACCGATCC CAGGAGCATC GGCCGCTTCT GTGAACACTG CCCCACCTGT TATACAGCCT 2580 GCAAGGAAAA CTGGAATTGT ATGCAATGCC TTCACCCTCA CAATTTGTCT CAGGCTATAC 2640 TTGATCAGTG CAAAACCTCA TGTGCTCTCA TGGAACAACA GCATTATGTC GACCAAACTT 2700 CAGAATGTTT CTCCAGCCCA AGCTACTTGA GAATATTTTT CATCATTTTC ATAGTTACAT 2760 TCTTGATTGG GTTGCTTAAA GTCCTGATCA TTAGACAGGT GATACTACAA TGGAATAGTA 2820 ATAAAATTAA GTCCTCATCA GATTACAGAG TGTCAGCCTC AAAAAAGGAT AAGTTGATTC 2880 TGCAAAGTGT TTGCACAAGA GCAGTCACCT ACCGACGTGA GAAGCCTGAA GAAATAAAAA 2940 TGGATATCAG CAAATTAAAT GCTCATGAAA CTTTCAGGTG CAACTTCTAA AAAAAGATTT 3000 TTAAACACTT AATGGGAAAC TGGAATTGTT AATAATTGCT CCTAAAGATT ATAATTTTAA 3060 AAGTCACAGG AGGAGACAAA TTGCTCACGG TCATGCCAGT TGCTGGTTGT ACACTCGAAC 3120 GAAGACTGAC AAGTATCCTC ATCATGATGT GACTCACATA GCTGCTGACT TTTTCAGAGA 3180 AAAATGTGTC TTACTACTGT TTGAGACTAG TGTCGTTGTA GCACTTTACT GTAATATATA 3240 ACTTATTTAG ATCAGCATAG AATGTAGATC CTCTGAAGAG CACTGATTAC ACTTTACAGG 3300 TACCTGTTAT CCCTACGCTT CCCAGAGAGA ACAATGCTGT GAGAGAGTTT AGCATTGTGT 3360 CACTACAAGG GTACAGTAAT CCCTGCACTG GACATGTGAG GAAAAAAATA ATCTGGCAAG 3420 TATATTCTAA GGTTGCCAAA CACTTCAACA GTTGGTGGTT GAATAGACAA GAACAGCTAG 3480 ATGAATAAAT GATTCGTGTT TCACTCTTTC AAGAGGTGAA CAGATACAAC CTTAATCTTA 3540 AAAGATTATT GCTTTTTAAA GTGTGTAGTT TTATGCATGT GTGTTTATGG TTTGCTTATT 3600 TTTGCAAGAT GGATACTAAT TCCAGCATTC TCTCCTCTTT GCCTTTATGT TTTGTTTTCT 3660 TTTTTACAGG ATAAGTTTAT GTATGTCACA GATGACTGGA TTAATTAAGT GCTAAGTTAC 3720 TACTGCCATA AAAAACTAAT AATACAATGT CACTTTATCA GAATACTAGT TTTAAAAGCT 3780 GAATGTTAA

SCARCLA 60 INTQVTP 120

SRKMAFF 180 SRDFRLGFGS YVDKTVSPYI SIHPERIHNQ CSDYNLDCMP PHGYIHVLSL TENITEFEKA 240 VHRQKISGNI DTPEGGFDAM LQAAVCESHI GWRKEAKRLL LVMTDQTSHL ALDSKLAGIV 300 VPNDGNCHLK NNVYVKSTTM EHPSLGQLSE KLIDNNINVI FAVQGKQFHW YKDLLPLLPG 360 TIAGEIESKA ANLNNLWEA YQKLISEVKV QVENQVQGIY FNITAICPDG SRKPGMEGCR 420 NVTSNDEVLF NVTVTMKKCD VTGGKNYAII KPIGFNETAK IHIHRNCSCQ CEDNRGPKGK 480 CVDETFLDSK CFQCDENKCH FDEDQFSSES CKSHKDQPVC SGRGVCVCGK CSCHKIKLGK 540 VYGKYCEKDD FSCPYHHGNL CAGHGECEAG RCQCFSG EG DRCQCPSAAA QHCVNSKGQV 600 CSGRGTCVCG RCECTDPRSI GRFCEHCPTC YTACKENWNC MQCLHPHNLS QAILDQCKTS 660 CALMEQQHYV DQTSECFSSP SYLRIFFIIF IVTFLIGLLK VLIIRQVILQ NSNKI SSS 720 DYRVSASKKD KLILQSVCTR AVTYRREKPE EIKMDISKLN AHETFRCNF

Seq ID NO: 57 DNA sequence

Nucleic Acid Accession ft: NM_001719

Coding sequence: 123..1418

1 11 21 31 41 51

I GGGCGCAGCG GGGCCCGTCT GCAGCAAGTG ACCGACGGCC GGGACGGCCG CCTGCCCCCT 60

CTGCCACCTG GGGCGGTGCG GGCCCGGAGC CCGGAGCCCG GGTAGCGCGT AGAGCCGGCG 120

CGATGCACGT GCGCTCACTG CGAGCTGCGG CGCCGCACAG CTTCGTGGCG CTCTGGGCAC 180

CCCTGTTCCT GCTGCGCTCC GCCCTGGCCG ACTTCAGCCT GGACAACGAG GTGCACTCGA 240

GCTTCATCCA CCGGCGCCTC CGCAGCCAGG AGCGGCGGGA GATGCAGCGC GAGATCCTCT 300

CCATTTTGGG CTTGCCCCAC CGCCCGCGCC CGCACCTCCA GGGCAAGCAC AACTCGGCAC 360

CCATGTTCAT GCTGGACCTG TACAACGCCA TGGCGGTGGA GGAGGGCGGC GGGCCCGGCG 420

GCCAGGGCTT CTCCTACCCC TACAAGGCCG TCTTCAGTAC CCAGGGCCCC CCTCTGGCCA 480

GCCTGCAAGA TAGCCATTTC CTCACCGACβ CCGACATGGT CATGAGCTTC GTCAACCTCG 540

TGGAACATGA CAAGGAATTC TTCCACCCAC GCTACCACCA TCGAGAGTTC CGGTTTGATC 600

TTTCCAAGAT CCCAGAAGGG GAAGCTGTCA CGGCAGCCGA ATTCCGGATC TACAAGGACT 660

ACATCCGGGA ACGCTTCGAC AATGAGACGT TCCGGATCAG CGTTTATCAG GTGCTCCAGG 720

AGCACTTGGG CAGGGAATCG GATCTCTTCC TGCTCGACAG CCGTACCCTC TGGGCCTCGG 780

AGGAGGGCTG GCTGGTGTTT GACATCACAG CCACCAGCAA CCACTGGGTG GTCAATCCGC 840

GGCACAACCT GGGCCTGCAG CTCTCGGTGG AGACGCTGGA TGGGCAGAGC ATCAACCCCA 900

AGTTGGCGGG CCTGATTGGG CGGCACGGGC CCCAGAACAA GCAGCCCTTC ATGGTGGCTT 960

TCTTCAAGGC CACGGAGGTC CACTTCCGCA GCATCCGGTC CACGGGGAGC AAACAGCGCA 1020

GCCAGAACCG CTCCAAGACG CCCAAGAACC AGGAAGCCCT GCGGATGGCC AACGTGGCAG 1080

AGAACAGCAG CAGCGACCAG AGGCAGGCCT GTAAGAAGCA CGAGCTGTAT GTCAGCTTCC 1140

GAGACCTGGG CTGGCAGGAC TGGATCATCG CGCCTGAAGG CTACGCCGCC TACTACTGTG 1200

AGGGGGAGTG TGCCTTCCCT CTGAACTCCT ACATGAACGC CACCAACCAC GCCATCGTGC 1260

AGACGCTGGT CCACTTCATC AACCCGGAAA CGGTGCCCAA GCCCTGCTGT GCGCCCACGC 1320

AGCTCAATGC CATCTCCGTC CTCTACTTCG ATGACAGCTC CAACGTCATC CTGAAGAAAT 1380

ACAGAAACAT GGTGGTCCGG GCCTGTGGCT GCCACTAGCT CCTCCGAGAA TTCAGACCCT 1440

TTGGGGCCAA GTTTTTCTGG ATCCTCCATT GCTCGCCTTG GCCAGGAACC AGCAGACCAA 1500

CTGCCTTTTG TGAGACCTTC CCCTCCCTAT CCCCAACTTT AAAGGTGTGA GAGTATTAGG 1560

AAACATGAGC AGCATATGGC TTTTGATCAG TTTTTCAGTG GCAGCATCCA ATGAACAAGA 1620

TCCTACAAGC TGTGCAGGCA AAACCTAGCA GGAAAAAAAA ACAACGCATA AAGAAAAATG 1680

GCCGGGCCAG GTCATTGGCT GGGAAGTCTC AGCCATGCAC GGACTCGTTT CCAGAGGTAA 1740

TTATGAGCGC CTACCAGCCA GGCCACCCAG CCGTGGGAGG AAGGGGGCGT GGCAAGGGGT 1800

GGGCACATTG GTGTCTGTGC GAAAGGAAAA TTGACCCGGA AGTTCCTGTA ATAAATGTCA 1860 CAATAAAACG AATGAATG

Seq ID NO: 58 Protein sequence Protein Accession ft: NP_001710 1 11 21 31 41 51

I I I I I I

MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS 60

ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG QGFSYPYKAV FSTQGPPLAS 120

LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR YHHREFRFDL SKIPEGEAVT AAEFRIYKDY 180

IRERFDNETF RISVYQVLQE HLGRESDLFL LDSRTLWASE EG LVFDITA TSNHWWNPR 240

HNLGLQLSVE TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS 300

QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQD IIA PEGYAAYYCE 360

GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ LNAISVLYFD DSSNVILKKY 420 RNMWRACGC H

Seq ID NO: 59 DNA sequence

Nucleic Acid Accession #: NM_002821

Coding sequence: 150..3362

1 11 21 31 41 51

I I I I I I

AACTCCCGCC TCGGGACGCC TCGGGGTCGG GCTCCGβCTG CGGCTGCTGC TGCGGCGCCC 60

GCGCTCCGGT GCGTCCGCCT CCTGTGCCCG CCGCGGAGCA GTCTGCGGCC CGCCGTGCGC 120

CCTCAGCTCC TTTTCCTGAG CCCGCCGCGA TGGGAGCTGC GCGGGGATCC CCGGCCAGAC 180

CCCGCCGGTT GCCTCTGCTC AGCGTCCTGC TGCTGCCGCT GCTGGGCGGT ACCCAGACAG 240

CCATTGTCTT CATCAAGCAG CCGTCCTCCC AGGATGCACT GCAGGGGCGC CGGGCGCTGC 300

TTCGCTGTGA GGTTGAGGCT CCGGGCCCGG TACATGTGTA CTGGCTGCTC GATGGGGCCC 360

CTGTCCAGGA CACGGAGCGG CGTTTCGCCC AGGGCAGCAG CCTGAGCTTT GCAGCTGTGG 420

ACCGGCTGCA GGACTCTGGC ACCTTCCAGT GTGTGGCTCG GGATGATGTC ACTGGAGAAG 480

AAGCCCGCAG TGCCAACGCC TCCTTCAACA TCAAATGGAT TGAGGCAGGT CCTGTGGTCC 540

TGAAGCATCC AGCCTCGGAA GCTGAGATCC AGCCACAGAC CCAGGTCACA CTTCGTTGCC 600

ACATTGATGG GCACCCTCGG CCCACCTACC AATGGTTCCG AGATGGGACC CCCCTTTCTG 660

ATGGTCAGAG CAACCACACA GTCAGCAGCA AGGAGCGGAA CCTGACGCTC CGGCCAGCTG 720

GTCCTGAGCA TAGTGGGCTG TATTCCTGCT GCGCCCACAG TGCTTTTGGC CAGGCTTGCA 780

GCAGCCAGAA CTTCACCTTG AGCATTGCTG ATGAAAGCTT TGCCAGGGTG GTGCTGGCAC 840

CCCAGGACGT GGTAGTAGCG AGGTATGAGG AGGCCATGTT CCATTGCCAG TTCTCAGCCC 900

AGCCACCCCC GAGCCTGCAG TGGCTCTTTG AGGATGAGAC TCCCATCACT AACCGCAGTC 960

GCCCCCCACA CCTCCGCAGA GCCACAGTGT TTGCCAACGG GTCTCTGCTG CTGACCCAGG 1020

TCCGGCCACG CAATGCAGGG ATCTACCGCT GCATTGGCCA GGGGCAGAGG GGCCCACCCA 1080

TCATCCTGGA AGCCACACTT CACCTAGCAG AGATTGAAGA CATGCCGCTA TTTGAGCCAC 1140

GGGTGTTTAC AGCTGGCAGC GAGGAGCGTG TGACCTGCCT TCCCCCCAAG GGTCTGCCAG 1200

AGCCCAGCGT GTGGTGGGAG CACGCGGGAG TCCGGCTGCC CACCCATGGC AGGGTCTACC 1260

AGAAGGGCCA CGAGCTGGTG TTGGCCAATA TTGCTGAAAG TGATGCTGGT GTCTACACCT 1320

GCCACGCGGC CAACCTGGCT GGTCAGCGGA GACAGGATGT CAACATCACT GTGGCCACTG 1380

TGCCCTCCTG GCTGAAGAAG CCCCAAGACA GCCAGCTGGA GGAGGGCAAA CCCGGCTACT 1440

TGGATTGCCT GACCCAGGCC ACACCAAAAC CTACAGTTGT CTGGTACAGA AACCAGATGC 1500

TCATCTCAGA GGACTCACGG TTCGAGGTCT TCAAGAATGG GACCTTGCGC ATCAACAGCG 1S60

TGGAGGTGTA TGATGGGACA TGGTACCGTT GTATGAGCAG CACCCCAGCC GGCAGCATCG 1620

AGGCGCAAGC CCGTGTCCAA GTGCTGGAAA AGCTCAAGTT CACACCACCA CCCCAGCCAC 1680

AGCAGTGCAT GGAGTTTGAC AAGGAGGCCA CGGTGCCCTG TTCAGCCACA GGCCGAGAGA 1740

AGCCCACTAT TAAGTGGGAA CGGGCAGATG GGAGCAGCCT CCCAGAGTGG GTGACAGACA 1800

ACGCTGGGAC CCTGCATTTT GCCCGGGTGA CTCGAGATGA CGCTGGCAAC TACACTTGCA 1860

TTGCCTCCAA CGGGCCGCAG GGCCAGATTC GTGCCCATGT CCAGCTCACT GTGGCAGTTT 1920

TTATCACCTT CAAAGTGGAA CCAGAGCGTA CGACTGTGTA CCAGGGCCAC ACAGCCCTAC 1980

TGCAGTGCGA GGCCCAGGGG GACCCCAAGC CGCTGATTCA GTGGAAAGGC AAGGACCGCA 2040 TCCTGGACCC CACCAAGCTG GGACCCAGGA TGCACATCTT CCAGAATGGC TCCCTGGTGA 2100

TCCATGACGT GGCCCCTGAG GACTCAGGCC GCTACACCTG CATTGCAGGC AACAGCTGCA 2160

ACATCAAGCA CACGGAGGCC CCCCTCTATG TCGTGGACAA GCCTGTGCCG GAGGAGTCGG 2220

AGGGCCCTGG CAGCCCTCCC CCCTACAAGA TGATCCAGAC CATTGGGTTG TCGGTGGGTG 2280

CCGCTGTGGC CTACATCATT GCCGTGCTGG GCCTCATGTT CTACTGCAAG AAGCGCTGCA 2340

AAGCCAAGCG GCTGCAGAAG CAGCCCGAGG GCGAGGAGCC AGAGATGGAA TGCCTCAACG 2400

GAGGGCCTTT GCAGAACGGG CAGCCCTCAG CAGAGATCCA AGAAGAAGTG GCCTTGACCA 2460

GCTTGGGCTC CGGCCCCGCG GCCACCAACA AACGCCACAG CACAAGTGAT AAGATGCACT 2520

TCCCACGGTC TAGCCTGCAG CCCATCACCA CGCTGGGGAA GAGTGAGTTT GGGGAGGTGT 2580 0 TCCTGGCAAA GGCTCAGGGC TTGGAGGAGG GAGTGGCAGA GACCCTGGTA CTTGTGAAGA 2640

GCCTGCAGAC GAAGGATGAG CAGCAGCAGC TGGACTTCCG GAGGGAGTTG GAGATGTTTG 2700

GGAAGCTGAA CCACGCCAAC GTGGTGCGGC TCCTGGGGCT GTGCCGGGAG GCTGAGCCCC 2760

ACTACATGGT GCTGGAATAT GTGGATCTGG GAGACCTCAA GCAGTTCCTG AGGATTTCCA 2820

AGAGCAAGGA TGAAAAATTG AAGTCACAGC CCCTCAGCAC CAAGCAGAAG GTGGCCCTAT 2880 5 GCACCCAGGT AGCCCTGGGC ATGGAGCACC TGTCCAACAA CCGCTTTGTG CATAAGGACT 2940

TGGCTGCGCG TAACTGCCTG GTCAGTGCCC AGAGACAAGT GAAGGTGTCT GCCCTGGGCC 3000

TCAGCAAGGA TGTGTACAAC AGTGAGTACT ACCACTTCCG CCAGGCCTGG GTGCCGCTGC 3060

GCTGGATGTC CCCCGAGGCC ATCCTGGAGG GTGACTTCTC TACCAAGTCT GATGTCTGGG 3120

CCTTCGGTGT GCTGATGTGG GAAGTGTTTA CACATGGAGA GATGCCCCAT GGTGGGCAGG 3180 0 CAGATGATGA AGTACTGGCA GATTTGCAGG CTGGGAAGGC TAGACTTCCT CAGCCCGAGG 3240

GCTGCCCTTC CAAACTCTAT CGGCTGATGC AGCGCTGCTG GGCCCTCAGC CCCAAGGACC 3300

GGCCCTCCTT CAGTGAGATT GCCAGCGCCC TGGGAGACAG CACCGTGGAC AGCAAGCCGT 3360

GAGGAGGGAG CCCGCTCAGG ATGGCCTGGG CAGGGGAGGA CATCTCTAGA GGGAAGCTCA 3420

CAGCATGATG GGCAAGATCC CTGTCCTCCT GGGCCCTGAG GTGCCCTAGT GCAACAGGCA 3480 5 TTGCTGAGGT CTGAGCAGGG CCTGGCCTTT CCTCCTCTTC CTCACCCTCA TCCTTTGGGA 3540

GGCTGACTTG GACCCAAACT GGGCGACTAG GGCTTTGAGC TGGGCAGTTT CCCCTGCCAC 3600

CTCTTCCTCT ATCAGGGACA GTGTGGGTGC CACAGGTAAC CCCAATTTCT GGCCTTCAAC 3660

TTCTCCCCTT GACCGGGTCC AACTCTGCCA CTCATCTGCC AACTTTGCCT GGGGAGGGCT 3720

AGGCTTGGGA TGAGCTGGGT TTGTGGGGAG TTCCTTAATA TTCTCAAGTT CTGGGCACAC 3780 0 AGGGTTAATG AGTCTCTTGC CCACTGGTCC ACTTGGGGGT CTAGACCAGG ATTATAGAGG 3840

ACACAGCAAG TGAGTCCTCC CCACTCTGGG CTTGTGCACA CTGACCCAGA CCCACGTCTT 3900

CCCCACCCTT CTCTCCTTTC CTCATCCTAA GTGCCTGGCA GATGAAGGAG TTTTCAGGAG 3960

CTTTTGACAC TATATAAACC GCCCTTTTTG TATGCACCAC GGGCGGCTTT TATATGTAAT 4020

TGCAGCGTGG GGTGGGTGGG CATGGGAGGT AGGGGTGGGC CCTGGAGATG AGGAGGGTGG 4080 5 GCCATCCTTA CCCCACACTT TTATTGTTGT CGTTTTTTGT TTGTTTTGTT TTTTTGTTTT 4140 TGTTTTTGTT TTTACACTCG CTGCTCTCAA TAAATAAGCC TTTTTTA

Seq ID NO: 60 Protein sequence Protein Accession ft: NP_002812 0 1 11 21 31 41 51

I I I I I I

MGAARGSPAR PRRLPLLSVL LLPLLGGTQT AIVFIKQPSS QDALQGRRAL LRCEVEAPGP 60

VHVYWLLDGA PVQDTERRFA QGSSLSFAAV DRLQDSGTFQ CVARDDVTGE EARSANASFN 120

IKWIEAGPW LKHPASEAEI QPQTQVTLRC HIDGHPRPTY Q FRDGTPLS DGQSNHTVSS 180 5 KERNLTLRPA GPEHSGLYSC CAHSAFGQAC SSQNFTLSIA DESFARWLA PQDVWARYE 240

EAMFHCQFSA QPPPSLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGIYR 300

CIGQGQRGPP IILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP EPS KWEHAG 360

VRLPTHGRVY QKGHELVLAN IAESDAGVYT CHAANLAGQR RQDVNITVAT VPS LKKPQD 420

SQLEEGKPGY LDCLTQATPK PTWWYRNQM LISEDSRFEV FKNGTLRINS VEVYDGTWYR 480 0 CMSSTPAGSI EAQARVQVLE KLKFTPPPQP QQCMEFDKEA TVPCSATGRE KPTIKWERAD 540

GSSLPEWVTD NAGTLHFARV TRDDAGNYTC IASNGPQGQI RAHVQLTVAV FITFKVEPER 600

TTVYQGHTAL LQCEAQGDPK PLIQ KGKDR ILDPTKLGPR MHIFQNGSLV IHDVAPEDSG 660

RYTCIAGNSC NIKHTEAPLY WDKPVPEES EGPGSPPPYK MIQTIGLSVG AAVAYIIAVL 720

GLMFYCKKRC KAKRLQKQPE GEEPEMECLN GGPLQNGQPS AEIQEEVALT SLGSGPAATN 780 5 KRHSTSDKMH FPRSSLQPIT TLGKSEFGEV FLAKAQGLEE GVAETLVLVK SLQTKDEQQQ 840

LDFRRELEMF GKLNHANWR LLGLCREAEP HYMVLEYVDL GDLKQFLRIS KSKDEKLKSQ 900

PLSTKQKVAL CTQVALGMEH LSNNRFVHKD LAARNCLVSA QRQVKVSALG LSKDVYNSEY 960

YHFRQA VPL R MSPEAILE GDFSTKSDVW AFGVLM EVF THGEMPHGGQ ADDEVLADLQ 1020 AGKARLPQPE GCPSKLYRLM QRC ALSPKD RPSFSEIASA LGDSTVDSKP

60

Seq ID NO: 61 DNA sequence Nucleic Acid Accession ft: NM_006103 Coding sequence: 29..406 ,._ 1 11 21 31 41 51

65 i i i i i i

CACCTGCACC CCGCCCGGGC ATAGCACCAT GCCTGCTTGT CGCCTAGGCC CGCTAGCCGC 60

CGCCCTCCTC CTCAGCCTGC TGCTGTTCGG CTTCACCCTA GTCTCAGGCA CAGGAGCAGA 120

GAAGACTGGC GTGTGCCCCG AGCTCCAGGC TGACCAGAAC TGCACGCAAG AGTGCGTCTC 180

GGACAGCGAA TGCGCCGACA ACCTCAAGTG CTGCAGCGCG GGCTGTGCCA CCTTCTGCCT 240

70 TCTCTGCCCA AATGATAAGG AGGGTTCCTG CCCCCAGGTG AACATTAACT TTCCCCAGCT 300

CGGCCTCTGT CGGGACCAGT GCCAGGTGGA CAGCCAGTGT CCTGGCCAGA TGAAATGCTG 360

CCGCAATGGC TGTGGGAAGG TGTCCTGTGT CACTCCCAAT TTCTGAGGTC CAGCCACCAC 420

CAGGCTGAGC AGTGAGGAGA GAAAGTTTCT GCCTGGCCCT GCATCTGGTT CCAGCCCACC 480

TGCCCTCCCC TTTTTCGGGA CTCTGTATTC CCTCTTGGGC TGACCACAGC TTCTCCCTTT 540

75 CCCAACCAAT AAAGTAACCA CTTTCAGCAA AAAAAAAAAA AAAA

Seq ID NO: 62 Protein sequence Protein Accession ft: NP_006094 _-. 1 11 21 31 41 51

80 i i i i i i

MPACRLGPLA AALLLSLLLF GFTLVSGTGA EKTGVCPELQ ADQNCTQECV SDSECADNLK 60 CCSAGCATFC LLCPNDKEGS CPQVNINFPQ LGLCRDQCQV DSQCPGQMKC CRNGCGKVSC 120 VTPNF

85 Seq ID NO: 63 DNA sequence Nucleic Acid Accession ft: NM_0012 Coding sequence: 274..1782 1 11 21 31 41 51

I I I 1 1 I 1

CGCGGGGCGC GGAGTCGGCG GGGCCTCGCG GGACGCGGGC AGTGCGGAGA CCGCGGCGCT 60 GAGGACGCGG GAGCCGGGAG CGCACGCGCG GGGTGGAGTT CAGCCTACTC TTTCTTAGAT 120 GTGAAAGGAA AGGAAGATCA TTTCATGCCT TGTTGATAAA GGTTCAGACT TCTGCTGATT 180 CATAACCATT TGGCTCTGAG CTATGACAAG AGAGGAAACA AAAAGTTAAA CTTACAAGCC 240 TGCCATAAGT GAGAAGCAAA CTTCCTTGAT AACATGCTTT TGCGAAGTGC AGGAAAATTA 300 AATGTGGGCA CCAAGAAAGA GGATGGTGAG AGTACAGCCC CCACCCCCCG TCCAAAGGTC 360 TTGCGTTGTA AATGCCACCA CCATTGTCCA GAAGACTCAG TCAACAATAT TTGCAGCACA 420 GACGGATATT GTTTCACGAT GATAGAAGAG GATGACTCTG GGTTGCCTGT GGTCACTTCT 480 GGTTGCCTAG GACTAGAAGG CTCAGATTTT CAGTGTCGGG ACACTCCCAT TCCTCATCAA 540 AGAAGATCAA TTGAATGCTG CACAGAAAGG AACGAATGTA ATAAAGACCT ACACCCTACA 600 CTGCCTCCAT TGAAAAACAG AGATTTTGTT GATGGACCTA TACACCACAG GGCTTTACTT 660 ATATCTGTGA CTGTCTGTAG TTTGCTCTTG GTCCTTATCA TATTATTTTG TTACTTCCGG 720 TATAAAAGAC AAGAAACCAG ACCTCGATAC AGCATTGGGT TAGAACAGGA TGAAACTTAC 780 ATTCCTCCTG GAGAATCCCT GAGAGACTTA ATTGAGCAGT CTCAGAGCTC AGGAAGTGGA 840 TCAGGCCTCC CTCTGCTGGT CCAAAGGACT ATAGCTAAGC AGATTCAGAT GGTGAAACAG 900 ATTGGAAAAG GTCGCTATGG GGAAGTTTGG ATGGGAAAGT GGCGTGGCGA AAAGGTAGCT 960 GTGAAAGTGT TCTTCACCAC AGAGGAAGCC AGCTGGTTCA GAGAGACAGA AATATATCAG 1020 ACAGTGTTGA TGAGGCATGA AAACATTTTG GGTTTCATTG CTGCAGATAT CAAAGGGACA 1080 GGGTCCTGGA CCCAGTTGTA CCTAATCACA GACTATCATG AAAATGGTTC CCTTTATGAT 1140 TATCTGAAGT CCACCACCCT AGACGCTAAA TCAATGCTGA AGTTAGCCTA CTCTTCTGTC 1200 AGTGGCTTAT GTCATTTACA CACAGAAATC TTTAGTACTC AAGGCAAACC AGCAATTGCC 1260 CATCGAGATC TGAAAAGTAA AAACATTCTG GTGAAGAAAA ATGGAACTTG CTGTATTGCT 1320 GACCTGGGCC TGGCTGTTAA ATTTATTAGT GATACAAATG AAGTTGACAT ACCACCTAAC 1380 ACTCGAGTTG GCACCAAACG CTATATGCCT CCAGAAGTGT TGGACGAGAG CTTGAACAGA 1440 AATCACTTCC AGTCTTACAT CATGGCTGAC ATGTATAGTT TTGGCCTCAT CCTTTGGGAG 1500 GTTGCTAGGA GATGTGTATC AGGAGGTATA GTGGAAGAAT ACCAGCTTCC TTATCATGAC 1560 CTAGTGCCCA GTGACCCCTC TTATGAGGAC ATGAGGGAGA TTGTGTGCAT CAAGAAGTTA 1620 CGCCCCTCAT TCCCAAACCG GTGGAGCAGT GATGAGTGTC TAAGGCAGAT GGGAAAACTC 1680 ATGACAGAAT GCTGGGCTCA CAATCCTGCA TCAAGGCTGA CAGCCCTGCG GGTTAAGAAA 1740 ACACTTGCCA AAATGTCAGA GTCCCAGGAC ATTAAACTCT GATAGGAGAG GAAAAGTAAG 1800 CATCTCTGCA GAAAGCCAAC AGGTACTCTT CTGTTTGTGG GCAGAGCAAA AGACATCAAA 1860 TAAGCATCCA CAGTACAAGC CTTGAACATC GTCCTGCTTC CCAGTGGGTT CAGACCTCAC 1920 CTTTCAGGGA GCGACCTGGG CAAAGACAGA GAAGCTCCCA GAAGGAGAGA TTGATCCGTG 1980 TCTGTTTGTA GGCGGAGAAA CCGTTGGGTA ACTTGTTCAA GATATGATGC AT

Seq ID NO: 64 Protein sequence Protein Accession ft: NP_001194 1 11 21 31 51

I I I I

MLLRSAGKLN VGTKKEDGES TAPTPRPKVL RCKCHHHCPE DSVNNICSTD GYCFTMIEED 60 DSGLPWTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD 120 GPIHHRALLI SVTVCSLLLV LIILFCYFRY KRQETRPRYS IGLEQDETYI PPGESLRDLI 180 EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 240 WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLY ITD YHENGSLYDY LKSTTLDAKS 300 MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 360 TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEV ARRCVSGGIV 420 EEYQLPYHDL VPSDPΞYEDM REIVCIKKLR PSFPNR SSD ECLRQMGKLM TEC AHNPAS 480 RLTALRVKKT LAKMSESQDI KL

Seq ID NO: 65 DNA sequence

Nucleic Acid Accession ft: NM_006475.1

Coding sequence: 28..2538

1 11 21 31 AtACAGAACTG CiAACGGAGAG AlCTCAAGATG AlTTCCCTTTT TACCCATGTT TTCTCTACTA 60 TTGCTGCTTA TTGTTAACCC TATAAACGCC AACAATCATT ATGACAAGAT CTTGGCTCAT 120 AGTCGTATCA GGGGTCGGGA CCAAGGCCCA AATGTCTGTG CCCTTCAACA GATTTTGGGC 180 ACCAAAAAGA AATACTTCAG CACTTGTAAG AACTGGTATA AAAAGTCCAT CTGTGGACAG 240 AAAACGACTG TTTTATATGA ATGTTGCCCT GGTTATATGA GAATGGAAGG AATGAAAGGC 300 TGCCCAGCAG TTTTGCCCAT TGACCATGTT TATGGCACTC TGGGCATCGT GGGAGCCACC 360 ACAACGCAGC GCTATTCTGA CGCCTCAAAA CTGAGGGAGG AGATCGAGGG AAAGGGATCC 420 TTCACTTACT TTGCACCGAG TAATGAGGCT TGGGACAACT TGGATTCTGA TATCCGTAGA 480 GGTTTGGAGA GCAACGTGAA TGTTGAATTA CTGAATGCTT TACATAGTCA CATGATTAAT 540 AAGAGAATGT TGACCAAGGA CTTAAAAAAT GGCATGATTA TTCCTTCAAT GTATAACAAT 600 TTGGGGCTTT TCATTAACCA TTATCCTAAT GGGGTTGTCA CTGTTAATTG TGCTCGAATC 660 ATCCATGGGA ACCAGATTGC AACAAATGGT GTTGTCCATG TCATTGACCG TGTGCTTACA 720 CAAATTGGTA CCTCAATTCA AGACTTCATT GAAGCAGAAG ATGACCTTTC ATCTTTTAGA 780 GCAGCTGCCA TCACATCGGA CATATTGGAG GCCCTTGGAA GAGACGGTCA CTTCACACTC 840 TTTGCTCCCA CCAATGAGGC TTTTGAGAAA CTTCCACGAG GTGTCCTAGA AAGGTTCATG 900 GGAGACAAAG TGGCTTCCGA AGCTCTTATG AAGTACCACA TCTTAAATAC TCTCCAGTGT 960 TCTGAGTCTA TTATGGGAGG AGCAGTCTTT GAGACGCTGG AAGGAAATAC AATTGAGATA 1020 GGATGTGACG GTGACAGTAT AACAGTAAAT GGAATCAAAA TGGTGAACAA AAAGGATATT 1080 GTGACAAATA ATGGTGTGAT CCATTTGATT GATCAGGTCC TAATTCCTGA TTCTGCCAAA 1140 CAAGTTATTG AGCTGGCTGG AAAACAGCAA ACCACCTTCA CGGATCTTGT GGCCCAATTA 1200 GGCTTGGCAT CTGCTCTGAG GCCAGATGGA GAATACACTT TGCTGGCACC TGTGAATAAT 1260 GCATTTTCTG ATGATACTCT CAGCATGGTT CAGCGCCTCC TTAAATTAAT TCTGCAGAAT 1320 CACATATTGA AAGTAAAAGT TGGCCTTAAT GAGCTTTACA ACGGGCAAAT ACTGGAAACC 1380 ATCGGAGGCA AACAGCTCAG AGTCTTCGTA TATCGTACAG CTGTCTGCAT TGAAAATTCA 1440 TGCATGGAGA AAGGGAGTAA GCAAGGGAGA AACGGTGCGA TTCACATATT CCGCGAGATC 1500 ATCAAGCCAG CAGAGAAATC CCTCCATGAA AAGTTAAAAC AAGATAAGCG CTTTAGCACC 1560 TTCCTCAGCC TACTTGAAGC TGCAGACTTG AAAGAGCTCC TGACACAACC TGGAGACTGG 1620 ACATTATTTG TGCCAACCAA TGATGCTTTT AAGGGAATGA CTAGTGAAGA AAAAGAAATT 1680 CTGATACGGG ACAAAAATGC TCTTCAAAAC ATCATTCTTT ATCACCTGAC ACCAGGAGTT 1740 TTCATTGGAA AAGGATTTGA ACCTGGTGTT ACTAACATTT TAAAGACCAC ACAAGGAAGC 1800 AAAATCTTTC TGAAAGAAGT AAATGATACA CTTCTGGTGA ATGAATTGAA ATCAAAAGAA 1860 TCTGACATCA TGACAACAAA TGGTGTAATT CATGTTGTAG ATAAACTCCT CTATCCAGCA 1920 GACACACCTG TTGGAAATGA TCAACTGCTG GAAATACTTA ATAAATTAAT CAAATACATC 1980 CAAATTAAGT TTGTTCGTGG TAGCACCTTC AAAGAAATCC CCGTGACTGT CTATACAACT 2040 AAAATTATAA CCAAAGTTGT GGAACCAAAA ATTAAAGTGA TTGAAGGCAG TCTTCAGCCT 2100 ATTATCAAAA CTGAAGGACC CACACTAACA AAAGTCAAAA TTGAAGGTGA ACCTGAATTC 2160 AGACTGATTA AAGAAGGTGA AACAATAACT GAAGTGATCC ATGGAGAGCC AATTATTAAA 2220 AAATACACCA AAATCATTGA TGGAGTGCCT GTGGAAATAA CTGAAAAAGA GACACGAGAA 2280 GAACGAATCA TTACAGGTCC TGAAATAAAA TACACTAGGA TTTCTACTGG AGGTGGAGAA 2340 ACAGAAGAAA CTCTGAAGAA ATTGTTACAA GAAGAGGTCA CCAAGGTCAC CAAATTCATT 2400 GAAGGTGGTG ATGGTCATTT ATTTGAAGAT GAAGAAATTA AAAGACTGCT TCAGGGAGAC 2460 ACACCCGTGA GGAAGTTGCA AGCCAACAAA AAAGTTCAAG GTTCTAGAAG ACGATTAAGG 2520 GAAGGTCGTT CTCAGTGAAA ATCCAAAAAC CAGAAAAAAA TGTTTATACA ACCCTAAGTC 2580 AATAACCTGA CCTTAGAAAA TTGTGAGAGC CAAGTTGACT TCAGGAACTG AAACATCAGC 2640 ACAAAGAAGC AATCATCAAA TAATTCTGAA CACAAATTTA ATATTTTTTT TTCTGAATGA 2700 GAAACATGAG GGAAATTGTG GAGTTAGCCT CCTGTGGTAA AGGAATTGAA GAAAATATAA 2760 CACCTTACAC CCTTTTTCAT CTTGACATTA AAAGTTCTGG CTAACTTTGG AATCCATTAG 2820 AGAAAAATCC TTGTCACCAG ATTCATTACA ATTCAAATCG AAGAGTTGTG AACTGTTATC 2880 CCATTGAAAA GACCGAGCCT TGTATGTATG TTATGGATAC ATAAAATGCA CGCAAGCCAT 2940 TATCTCTCCA TGGGAAGCTA AGTTATAAAA ATAGGTGCTT GGTGTACAAA ACTTTTTATA 3000 TCAAAAGGCT TTGCACATTT CTATATGAGT GGGTTTACTG GTAAATTATG TTATTTTTTA 3060 CAACTAATTT TGTACTCTCA GAATGTTTGT CATATGCTTC TTGCAATGCA TATTTTTTAA 3120 TCTCAAACGT TTCAATAAAA CCATTTTTCA GATATAAAGA GAATTACTTC AAATTGAGTA 3180 ATTCAGAAAA ACTCAAGATT TAAGTTAAAA AGTGGTTTGG ACTTGGGAA

Seq ID NO: 66 protein sequence Protein Accession ft: NP_006466.1 1 11 21 31 41 51

I I I

MIPFLPMFSL LLLLIVN IN ANNHYDKILA HSRIRGRDQG PNVCALQQIL GTKKKYFSTC 60 KNWYKKSICG QKTTVLYECC PGYMRMEGMK GCPAVLPIDH VYGTLGIVGA TTTQRYSDAS 120 KLREEIEGKG SFTYFAPSNE AWDNLDSDIR RGLESNVNVE LLNALHSHMI NKRMLTKDLK 180 NGMIIPSMYN NLGLFINHYP NGWTVNCAR IIHGNQIATN GWHVIDRVL TQIGTSIQDF 240 IEAEDDLSSF RAAAITSDIL EALGRDGHFT LFAPTNEAFE KLPRGVLERF MGDKVASEAL 300 MKYHILNTLQ CSESIMGGAV FETLEGNTIE IGCDGDSITV NGIKMVNKKD IVTNNGVIHL 360 IDQVLIPDSA KQVIELAGKQ QTTFTDLVAQ LGLASALRPD GEYTLLAPVN NAFSDDTLSM 420 VQRLLKLILQ NHILKVKVGL NELYNGQILE TIGGKQLRVF VYRTAVCIEN SCMEKGSKQG 480 RNGAIHIFRE IIKPAEKSLH EKLKQDKRFS TFLSLLEAAD LKELLTQPGD WTLFVPTNDA 540 FKGMTSEEKE ILIRDKNALQ NIILYHLTPG VFIGKGFEPG VTNILKTTQG SKIFLKEVND 600 TLLVNELKSK ESDIMTTNGV IHWDKLLYP ADTPVGNDQL LEILNKLIKY IQIKFVRGST 660 FKEIPVTVYT TKIITKWEP KIKVIEGSLQ PI1KTEGPTL TKVKIEGEPE FRLIKEGETI 720 TEVIHGEPII KKYTKIIDGV PVEITEKETR EERIITGPEI KYTRISTGGG ETEETLKKLL 780 QEEVTKVTKF IEGGDGHLFE DEEIKRLLQG DTPVRKLQAN KKVQGSRRRL REGRSQ

Seq ID NO: 67 DNA sequence

Nucleic Acid Accession ft: EOS sequence

Coding sequence: 1-927

1 11 21 31 SI AtTGCCTGGGG GiGTGCTCCCG GlGGCCCCGCC GlCCGGGGACG GGCGTCTGCG GCTGGCGCGA 60 CTAGCGCTGG TACTCCTGGG CTGGGTCTCC TCGTCTTCTC CCACCTCCTC GGCATCCTCC 120 TTCTCCTCCT CGGCGCCGTT CCTGGCTTCC GCCGTGTCCG CCCAGCCCCC GCTGCCGGAC 180 CAGTGCCCCG CGCTGTGCGA GTGCTCCGAG GCAGCGCGCA CAGTCAAGTG CGTTAACCGC 240 AATCTGACCG AGGTGCCCAC GGACCTGCCC GCCTACGTGC GCAACCTCTT CCTTACCGGC 300 AACCAGCTGG CCAGCAACCA CTTCCTTTAC CTGCCGCGGG ATGTGCTGGC CCAACTGCCC 360 AGCCTCAGGC ACCTGGACTT AAGTAATAAT TCGCTGGTGA GCCTGACCTA CGTGTCCTTC 420 CGCAACCTGA CACATCTAGA AAGCCTCCAC CTGGAGGACA ATGCCCTCAA GGTCCTTCAC 480 AATGGCACCC TGGCTGAGTT GCAAGGTCTA CCCCACATTA GGGTTTTCCT GGACAACAAT 540 CCCTGGGTCT GCGACTGCCA CATGGCAGAC ATGGTGACCT GGCTCAAGGA AACAGAGGTA 600 GTGCAGGGCA AAGACCGGCT CACCTGTGCA TATCCGGAAA AAATGAGGAA TCGGGTCCTC 660 TTGGAACTCA ACAGTGCTGA CCTGGACTGT GACCCGATTC TTCCCCCATC CCTGCAAACC 720 TCTTATGTCT TCCTGGGTAT TGTTTTAGCC CTGATAGGCG CTATTTTCCT CCTGGTTTTG 780 TATTTGAACC GCAAGGGGAT AAAAAAGTGG ATGCATAACA TCAGAGATGC CTGCAGGGAT 840 CACATGGAAG GGTATCATTA CAGATATGAA ATCAATGCGG ACCCCAGATT AACAAACCTC 900 AGTTCTAACT CGGATGTCCT CGAGTGA

Seq ID NO: 68 Protein sequence Protein Accession ft: EOS sequence 1 11 21 31 41 51

I 1 I I 1 1 | 1

MPGGCSRGPA AGDGRLRLAR LALVLLGWVS SSSPTSSASS FSSSAPFLAS AVSAQPPLPD 60 QCPALCECSE AARTVKCVNR NLTEVPTDLP AYVRNLFLTG NQLASNHFLY LPRDVLAQLP 120 SLRHLDLSNN SLVSLTYVSF RNLTHLESLH LEDNALKVLH NGTLAELQGL PHIRVFLDNN 180 PWVCDCHMAD MVT LKETEV VQGKDRLTCA YPEKMRNRVL LELNSADLDC DPILPPSLQT 240 SYVFLGI LA LIGAIFLLVL YLNRKGIKKW MHNIRDACRD HMEGYHYRYE INADPRLTNL 300 SSNSDVLE

Seq ID NO: 69 DNA sequence

Nucleic Acid Accession ft: NM_000095.1

Coding sequence: 26.-2299

1 11 21 31 51

I I I I CAGCACCCAG CTCCCCGCCA CCGCCATGGT CCCCGACACC GCCTGCGTTC TTCTGCTCAC 60 CCTGGCTGCC CTCGGCGCGT CCGGACAGGG CCAGAGCCCG TTGGGCTCAG ACCTGGGCCC 120 GCAGATGCTT CGGGAACTGC AGGAAACCAA CGCGGCGCTG CAGGACGTGC GGGACTGGCT 180 GCGGCAGCAG GTCAGGGAGA TCACGTTCCT GAAAAACACG GTGATGGAGT GTGACGCGTG 240 CGGGATGCAG CAGTCAGTAC GCACCGGCCT ACCCAGCGTG CGGCCCCTGC TCCACTGCGC 300 GCCCGGCTTC TGCTTCCCCG GCGTGGCCTG CATCCAGACG GAGAGCGGCG GCCGCTGCGG 360 CCCCTGCCCC GCGGGCTTCA CGGGCAACGG CTCGCACTGC ACCGACGTCA ACGAGTGCAA 420 CGCCCACCCC TGCTTCCCCC GAGTCCGCTG TATCAACACC AGCCCGGGGT TCCGCTGCGA 480 GGCTTGCCCG CCGGGGTACA GCGGCCCCAC CCACCAGGGC GTGGGGCTGG CTTTCGCCAA 540 GGCCAACAAG CAGGTTTGCA CGGACATCAA CGAGTGTGAG ACCGGGCAAC ATAACTGCGT 600 CCCCAACTCC GTGTGCATCA ACACCCGGGG CTCCTTCCAG TGCGGCCCGT GCCAGCCCGG 660 CTTCGTGGGC GACCAGGCGT CCGGCTGCCA GCGCGGCGCA CAGCGCTTCT GCCCCGACGG 720 CTCGCCCAGC GAGTGCCACG AGCATGCAGA CTGCGTCCTA GAGCGCGATG GCTCGCGGTC 780 GTGCGTGTGT CGCGTTGGCT GGGCCGGCAA CGGGATCCTC TGTGGTCGCG ACACTGACCT 840 AGACGGCTTC CCGGACGAGA AGCTGCGCTG CCCGGAGCCG CAGTGCCGTA AGGACAACTG 900 CGTGACTGTG CCCAACTCAG GGCAGGAGGA TGTGGACCGC GATGGCATCG GAGACGCCTG 960 CGATCCGGAT GCCGACGGGG ACGGGGTCCC CAATGAAAAG GACAACTGCC CGCTGGTGCG 1020 GAACCCAGAC CAGCGCAACA CGGACGAGGA CAAGTGGGGC GATGCGTGCG ACAACTGCCG 1080 GTCCCAGAAG AACGACGACC AAAAGGACAC AGACCAGGAC GGCCGGGGCG ATGCGTGCGA 1140 CGACGACATC GACGGCGACC GGATCCGCAA CCAGGCCGAC AACTGCCCTA GGGTACCCAA 1200 CTCAGACCAG AAGGACAGTG ATGGCGATGG TATAGGGGAT GCCTGTGACA ACTGTCCCCA 1260 GAAGAGCAAC CCGGATCAGG CGGATGTGGA CCACGACTTT GTGGGAGATG CTTGTGACAG 1320 CGATCAAGAC CAGGATGGAG ACGGACATCA GGACTCTCGG GACAACTGTC CCACGGTGCC 1380 TAACAGTGCC CAGGAGGACT CAGACCACGA TGGCCAGGGT GATGCCTGCG ACGACGACGA 1440 CGACAATGAC GGAGTCCCTG ACAGTCGGGA CAACTGCCGC CTGGTGCCTA ACCCCGGCCA 1500 GGAGGACGCG GACAGGGACG GCGTGGGCGA CGTGTGCCAG GACGACTTTG ATGCAGACAA 1560 GGTGGTAGAC AAGATCGACG TGTGTCCGGA GAACGCTGAA GTCACGCTCA CCGACTTCAG 1620 GGCCTTCCAG ACAGTCGTGC TGGACCCGGA GGGTGACGCG CAGATTGACC CCAACTGGGT 1680 GGTGCTCAAC CAGGGAAGGG AGATCGTGCA GACAATGAAC AGCGACCCAG GCCTGGCTGT 1740 GGGTTACACT GCCTTCAATG GCGTGGACTT CGAGGGCACG TTCCATGTGA ACACGGTCAC 1800 GGATGACGAC TATGCGGGCT TCATCTTTGG CTACCAGGAC AGCTCCAGCT TCTACGTGGT 1860 CATGTGGAAG CAGATGGAGC AAACGTATTG GCAGGCGAAC CCCTTCCGTG CTGTGGCCGA 1920 GCCTGGCATC CAACTCAAGG CTGTGAAGTC TTCCACAGGC CCCGGGGAAC AGCTGCGGAA 1980 CGCTCTGTGG CATACAGGAG ACACAGAGTC CCAGGTGCGG CTGCTGTGGA AGGACCCGCG 2040 AAACGTGGGT TGGAAGGACA AGAAGTCCTA TCGTTGGTTC CTGCAGCACC GGCCCCAAGT 2100 GGGCTACATC AGGGTGCGAT TCTATGAGGG CCCTGAGCTG GTGGCCGACA GCAACGTGGT 2160 CTTGGACACA ACCATGCGGG GTGGCCGCCT GGGGGTCTTC TGCTTCTCCC AGGAGAACAT 2220 CATCTGGGCC AACCTGCGTT ACCGCTGCAA TGACACCATC CCAGAGGACT ATGAGACCCA 2280 TCAGCTGCGG CAAGCCTAGG GACCAGGGTG AGGACCCGCC GGATGACAGC CACCCTCACC 2340 GCGGCTGGAT GGGGGCTCTG CACCCAGCCC AAGGGGTGGC CGTCCTGAGG GGGAAGTGAG 2400 AAGGGCTCAG AGAGGACAAA ATAAAGTGTG TGTGCAGGG

Seq ID NO: 70 Protein sequence

Protein Accession ft: NP_000086.1

1 11 21 31 41 51

M IVPDTACVLL LITLAALGASG QIGQSPLGSDL GIPQMLRELQE TINAALQDVRD WILRQQVREIT 60

FLKNTVMECD ACGMQQSVRT GLPSVRPLLH CAPGFCFPGV ACIQTESGGR CGPCPAGFTG 120

NGSHCTDVNE CNAHPCPPRV RCINTSPGFR CEACPPGYSG PTHQGVGLAF AKANKQVCTD 180

INECETGQHN CVPNSVCINT RGSFQCGPCQ PGFVGDQASG CQRGAQRFCP DGSPSECHEH 240

ADCVLERDGS RSCVCRVG A GNGILCGRDT DLDGFPDEKL RCPEPQCRKD NCVTVPNSGQ 300

EDVDRDGIGD ACDPDADGDG VPNEKDNCPL VRNPDQRNTD EDKWGDACDN CRSQKNDDQK 360

DTDQDGRGDA CDDDIDGDRI RNQADNCPRV PNSDQKDSDG DGIGDACDNC PQKSNPDQAD 420

VDHDFVGDAC DSDQDQDGDG HQDSRDNCPT VPNSAQEDSD HDGQGDACDD DDDNDGVPDS 480

RDNCRLVPNP GQEDADRDGV GDVCQDDFDA DKWDKIDVC PENAEVTLTD FRAFQTWLD 540

PEGDAQIDPN WWLNQGREI VQTMNSDPGL AVGYTAFNGV DFEGTFHVNT VTDDDYAGFI 600

FGYQDSSSFY WMWKQMEQT YWQANPFRAV AEPGIQLKAV KSSTGPGEQL RNALWHTGDT 660

ESQVRLLWKD PRNVGWKDKK SYRWFLQHRP QVGYIRVRFY EGPELVADSN WLDTTMRGG 720 RLGVFCFSQE NIIWANLRYR CNDTIPEDYE THQLRQA

Seq ID NO : 71 DNA sequence

Nucleic Acid Accession ft : NM_024626

Coding sequence : 71. . 919

1 11 21 31 41 51

I T I I I I

GAGTCACCAA GGAAGGCAGC GGCAGCTCCA CTCAGCCAGT ACCCAGATAC GCTGGGAACC 60 TTCCCCAGCC ATGGCTTCCC TGGGGCAGAT CCTCTTCTGG AGCATAATTA GCATCATCAT 120 TATTCTGGCT GGAGCAATTG CACTCATCAT TGGCTTTGGT ATTTCAGGGA GACACTCCAT 180 CACAGTCACT ACTGTCGCCT CAGCTGGGAA CATTGGGGAG GATGGAATCC TGAGCTGCAC 240 TTTTGAACCT GACATCAAAC TTTCTGATAT CGTGATACAA TGGCTGAAGG AAGGTGTTTT 300 AGGCTTGGTC CATGAGTTCA AAGAAGGCAA AGATGAGCTG TCGGAGCAGG ATGAAATGTT 360 CAGAGGCCGG ACAGCAGTGT TTGCTGATCA AGTGATAGTT GGCAATGCCT CTTTGCGGCT 420 GAAAAACGTG CAACTCACAG ATGCTGGCAC CTACAAATGT TATATCATCA CTTCTAAAGG 480 CAAGGGGAAT GCTAACCTTG AGTATAAAAC TGGAGCCTTC AGCATGCCGG AAGTGAATGT S40 GGACTATAAT GCCAGCTCAG AGACCTTGCG GTGTGAGGCT CCCCGATGGT TCCCCCAGCC 600 CACAGTGGTC TGGGCATCCC AAGTTGACCA GGGAGCCAAC TTCTCGGAAG TCTCCAATAC 660 CAGCTTTGAG CTGAACTCTG AGAATGTGAC CATGAAGGTT GTGTCTGTGC TCTACAATGT 720 TACGATCAAC AACACATACT CCTGTATGAT TGAAAATGAC ATTGCCAAAG CAACAGGGGA 780 TATCAAAGTG ACAGAATCGG AGATCAAAAG GCGGAGTCAC CTACAGCTGC TAAACTCAAA 840 GGCTTCTCTG TGTGTCTCTT CTTTCTTTGC CATCAGCTGG GCACTTCTGC CTCTCAGCCC 900 TTACCTGATG CTAAAATAAT GTGCCTCGGC CACAAAAAAG CATGCAAAGT CATTGTTACA 960 ACAGGGATCT ACAGAACTAT TTCACCACCA GATATGACCT AGTTTTATAT TTCTGGGAGG 1020 AAATGAATTC ATATCTAGAA GTCTGGAGTG AGCAAACAAG AGCAAGAAAC AAAAAGAAGC 1080 CAAAAGCAGA AGGCTCCAAT ATGAACAAGA TAAATCTATC TTCAAAGACA TATTAGAAGΓ 1140 TGGGAAAATA ATTCATGTGA ACTAGAGTCA ACTGTGTCAG GGCTAAGAAA CCCTGGTTTT 1200 GAGTAGAAAA GGGCCTGGAA AGAGGGGAGC CAACAAATCT GTCTGCTTCC TCACATTAGT 1260

CATTGGCAAA TAAGCATTCT GTCTCTTTGG CTGCTGCCTC AGCACAGAGA GCCAGAACTC 1320

TATCGGGCAC CAGGATAACA TCTCTCAGTG AACAGAGTTG ACAAGGCCTA TGGGAAATGC 1380

CTGATGGGAT TATCTTCAGC TTGTTGAGCT TCTAAGTTTC TTTCCCTTCA TTCTACCCTG 1440

5 CAAGCCAAGT TCTGTAAGAG AAATGCCTGA GTTCTAGCTC AGGTTTTCTT ACTCTGAATT 1500

TAGATCTCCA GACCCTGCCT GGCCACAATT CAAATTAAGG CAACAAACAT ATACCTTCCA 1560

TGAAGCACAC ACAGACTTTT GAAAGCAAGG ACAATGACTG CTTGAATTGA GGCCTTGAGG 1620

AATGAAGCTT TGAAGGAAAA GAATACTTTG TTTCCAGCCC CCTTCCCACA CTCTTCATGT 1680

GTTAACCACT GCCTTCCTGG ACCTTGGAGC CACGGTGACT GTATTACATG TTGTTATAGA 1740

10 AAACTGATTT TAGAGTTCTG ATCGTTCAAG AGAATGATTA AATATACATT TCCTAAAAAA 1800 AAAAAAAAAA A

Seq ID NO: 72 Protein sequence protein Accession ft: NP_078902 15 1 11 21 31 41 SI

I I I I I I

MASLGQILF SIISIIIILA GAIALIIGFG ISGRHSITVT TVASAGNIGE DGILSCTFEP 60

DIKLSDIVIQ WLKEGVLGLV HEFKEGKDEL SEQDEMFRGR TAVFADQVIV GNASLRLKNV 120

QLTDAGTYKC YIITSKGKGN ANLEYKTGAF SMPEVNVDYN ASSETLRCEA PRWFPQPTW 180

20 ASQVDQGAN FSEVSNTSFE LNSENVTMKV VSVLYNVTIN NTYSCMIEND IAKATGDIKV 240 TESEI RRSH LQLLNSKASL CVSSFFAISW ALLPLSPYLM LK

Seq ID NO: 73 DNA sequence Nucleic Acid Accession ft: XM_057014 D Coding sequence: 143..874

1 11 21 3Ϊ 41 51

I I I I I I

GGGAGGGAGA GAGGCGCGCG GGTGAAAGGC GCATTGATGC AGCCTGCGGC GGCCTCGGAG 60

CGCGGCGGAG CCAGACGCTG ACCACGTTCC TCTCCTCGGT CTCCTCCGCC TCCAGCTCCG 120

30 CGCTGCCCGG CAGCCGGGAG CCATGCGACC CCAGGGCCCC GCCGCCTCCC CGCAGCGGCT 180

CCGCGGCCTC CTGCTGCTCC TGCTGCTGCA GCTGCCCGCG CCGTCGAGCG CCTCTGAGAT 240

CCCCAAGGGG AAGCAAAAGG CGCAGCTCCG GCAGAGGGAG GTGGTGGACC TGTATAATGG 300

AATGTGCTTA CAAGGGCCAG CAGGAGTGCC TGGTCGAGAC GGGAGCCCTG GGGCCAATGG 360

CATTCCGGGT ACACCTGGGA TCCCAGGTCG GGATGGATTC AAAGGAGAAA AGGGGGAATG 420

35 TCTGAGGGAA AGCTTTGAGG AGTCCTGGAC ACCCAACTAC AAGCAGTGTT CATGGAGTTC 480

ATTGAATTAT GGCATAGATC TTGGGAAAAT TGCGGAGTGT ACATTTACAA AGATGCGTTC 540

AAATAGTGCT CTAAGAGTTT TGTTCAGTGG CTCACTTCGG CTAAAATGCA GAAATGCATG 600

CTGTCAGCGT TGGTATTTCA CATTCAATGG AGCTGAATGT TCAGGACCTC TTCCCATTGA 660

AGCTATAATT TATTTGGACC AAGGAAGCCC TGAAATGAAT TCAACAATTA ATATTCATCG 720

40 CACTTCTTCT GTGGAAGGAC TTTGTGAAGG AATTGGTGCT GGATTAGTGG ATGTTGCTAT 780

CTGGGTTGGC ACTTGTTCAG ATTACCCAAA AGGAGATGCT TCTACTGGAT GGAATTCAGT 840

TTCTCGCATC ATTATTGAAG AACTACCAAA ATAAATGCTT TAATTTTCAT TTGCTACCTC 900

TTTTTTTATT ATGCCTTGGA ATGGTTCACT TAAATGACAT TTTAAATAAG TTTATGTATA 960

CATCTGAATG AAAAGCAAAG CTAAATATGT TTACAGACCA AAGTGTGATT TCACACTGTT 1020

45 TTTAAATCTA GCATTATTCA TTTTGCTTCA ATCAAAAGTG GTTTCAATAT TTTTTTTAGT 1080

TGGTTAGAAT ACTTTCTTCA TAGTCACATT CTCTCAACCT ATAATTTGGA ATATTGTTGT 1140

GGTCTTTTGT TTTTTCTCTT AGTATAGCAT TTTTAAAAAA ATATAAAAGC TACCAATCTT 1200

TGTACAATTT GTAAATGTTA AGAATTTTTT TTATATCTGT TAAATAAAAA TTATTTCCAA 1260 CAACCTTAAA AAAAAAAAAA AAAA

Seq ID NO: 74 Protein sequence Protein Accession ft: XP_057014 1 11 21 31 41 51

« JJ M 1RPQGPAASP Q IRLRGLLLLL L ILQLPAPSSA S 1EIPKGKQKA Q ILRQREWDL Y INGMCLQGPA 60

GVPGRDGSPG ANGIPGTPGI PGRDGFKGEK GECLRESFEE SWTPNYKQCS WSSLNYGIDL 120

GKIAECTFTK MRSNSALRVL FSGSLRLKCR NACCQRWYFT FNGAECSGPL PIEAIIYLDQ 180

GSPEMNSTIN IHRTSSVEGL CEGIGAGLVD VAIWVGTCSD YPKGDASTGW NSVSRIIIEE 240

60 ^LPK

Seq ID NO: 75 DNA sequence Nucleic Acid Accession #: BC010423 Coding sequence: 248..1780 ,. 1 11 21 31 41 51

65 I I I I I I

CACAGCGTGG GAAGCAGCTC TGGGGGAGCT CGGAGCTCCC GATCACGGCT TCTTGGGGGT 60

AGCTACGGCT GGGTGTGTAG AACGGGGCCG GGGCTGGGGC TGGGTCCCCT AGTGGAGACC 120

CAAGTGCGAG AGGCAAGAAC TCTGCAGCTT CCTGCCTTCT GGGTCAGTTC CTTATTCAAG 180

TCTGCAGCCG GCTCCCAGGG AGATCTCGGT GGAACTTCAG AAACGCTGGG CAGTCTGCCT 240

70 TTCAACCATG CCCCTGTCCC TGGGAGCCGA GATGTGGGGG CCTGAGGCCT GGCTGCTGCT 300

GCTGCTACTG CTGGCATCAT TTACAGGCCG GTGCCCCGCG GGTGAGCTGG AGACCTCAGA 360

CGTGGTAACT GTGGTGCTGG GCCAGGACGC AAAACTGCCC TGCTTCTACC GAGGGGACTC 420

CGGCGAGCAA GTGGGGCAAG TGGCATGGGC TCGGGTGGAC GCGGGCGAAG GCGCCCAGGA 480

ACTAGCGCTA CTGCACTCCA AATACGGGCT TCATGTGAGC CCGGCTTACG AGGGCCGCGT 540

75 GGAGCAGCCG CCGCCCCCAC GCAACCCCCT GGACGGCTCA GTGCTCCTGC GCAACGCAGT 600

GCAGGCGGAT GAGGGCGAGT ACGAGTGCCG GGTCAGCACC TTCCCCGCCG GCAGCTTCCA 660

GGCGCGGCTG CGGCTCCGAG TGCTGGTGCC TCCCCTGCCC TCACTGAATC CTGGTCCAGC 720

ACTAGAAGAG GGCCAGGGCC TGACCCTGGC AGCCTCCTGC ACAGCTGAGG GCAGCCCAGC 780

CCCCAGCGTG ACCTGGGACA CGGAGGTCAA AGGCACAACG TCCAGCCGTT CCTTCAAGCA 840

80 CTCCCGCTCT GCTGCCGTCA CCTCAGAGTT CCACTTGGTG CCTAGCCGCA GCATGAATGG 900

GCAGCCACTG ACTTGTGTGG TGTCCCATCC TGGCCTGCTC CAGGACCAAA GGATCACCCA 960

CATCCTCCAC GTGTCCTTCC TTGCTGAGGC CTCTGTGAGG GGCCTTGAAG ACCAAAATCT 1020

GTGGCACATT GGCAGAGAAG GAGCTATGCT CAAGTGCCTG AGTGAAGGGC AGCCCCCTCC 1080

CTCATACAAC TGGACACGGC TGGATGGGCC TCTGCCCAGT GGGGTACGAG TGGATGGGGA 1140

85 CACTTTGGGC TTTCCCCCAC TGACCACTGA GCACAGCGGC ATCTACGTCT GCCATGTCAG 1200 CAATGAGTTC TCCTCAAGGG ATTCTCAGGT CACTGTGGAT GTTCTTGACC CCCAGGAAGA 1260 CTCTGGGAAG CAGGTGGACC TAGTGTCAGC CTCGGTGGTG GTGGTGGGTG TGATCGCCGC 1320 ACTCTTGTTC TGCCTTCTGG TGGTGGTGGT GGTGCTCATG TCCCGATACC ATCGGCGCAA 1380 GGCCCAGCAG ATGACCCAGA AATATGAGGA GGAGCTGACC CTGACCAGGG AGAACTCCAT 1440 CCGGAGGCTG CATTCCCATC ACACGGACCC CAGGAGCCAG CCGGAGGAGA GTGTAGGGCT 1500 GAGAGCCGAG GGCCACCCTG ATAGTCTCAA GGACAACAGT AGCTGCTCTG TGATGAGTGA 1560 AGAGCCCGAG GGCCGCAGTT ACTCCACGCT GACCACGGTG AGGGAGATAG AAACACAGAC 1620 TGAACTGCTG TCTCCAGGCT CTGGGCGGGC CGAGGAGGAG GAAGATCAGG ATGAAGGCAT 1680 CAAACAGGCC ATGAACCATT TTGTTCAGGA GAATGGGACC CTACGGGCCA AGCCCACGGG 1740 CAATGGCATC TACATCAATG GGCGGGGACA CCTGGTCTGA CCCAGGCCTG CCTCCCTTCC 1800 CTAGGCCTGG CTCCTTCTGT TGACATGGGA GATTTTAGCT CATCTTGGGG GCCTCCTTAA 1860 ACACCCCCAT TTCTTGCGGA AGATGCTCCC CATCCCACTG ACTGCTTGAC CTTTACCTCC 1920 AACCCTTCTG TTCATCGGGA GGGCTCCACC AATTGAGTCT CTCCCACCAT GCATGCAGGT 1980 CACTGTGTGT GTGCATGTGT GCCTGTGTGA GTGTTGACTG ACTGTGTGTG TGTGGAGGGG 2040 TGACTGTCCG TGGAGGGGTG ACTGTGTCCG TGGTGTGTAT TATGCTGTCA TATCAGAGTC 2100 AAGTGAACTG TGGTGTATGT GCCACGGGAT TTGAGTGGTT GCGTGGGCAA CACTGTCAGG 2160 GTTTGGCGTG TGTGTCATGT GGCTGTGTGT GACCTCTGCC TGAAAAAGCA GGTATTTTCT 2220 CAGACCCCAG AGCAGTATTA ATGATGCAGA GGTTGGAGGA GAGAGGTGGA GACTGTGGCT 2280 CAGACCCAGG TGTGCGGGCA TAGCTGGAGC TGGAATCTGC CTCCGGTGTG AGGGAACCTG 2340 TCTCCTACCA CTTCGGAGCC ATGGGGGCAA GTGTGAAGCA GCCAGTCCCT GGGTCAGCCA 2400 GAGGCTTGAA CTGTTACAGA AGCCCTCTGC CCTCTGGTGG CCTCTGGGCC TGCTGCATGT 2460 ACATATTTTC TGTAAATATA CATGCGCCGG GAGCTTCTTG CAGGAATACT GCTCCGAATC 2S20 ACTTTTAATT TTTTTCTTTT TTTTTTCTTG CCCTTTCCAT TAGTTGTATT TTTTATTTAT 2580 TTTTATTTTT ATTTTTTTTT AGAGTTTGAG TCCAGCCTGG ACGATATAGC CAGACCCTGT 2640 CTGTAAAAAA ACCAAAACCC AAAAAAAAAA AAAAAAAAAA

Seq ID NO: 76 Protein sequence

Protein Accession ft: AAH10423

1 11 21 31 41 51

I

MlPLSLGAEM GlPEAWLLLLL LlLASFTGRCP AlGELETSDW TlWLGQDAKL PCFYRGDSGE 60

QVGQVAWARV DAGEGAQELA LLHSKYGLHV SPAYEGRVEQ PPPPRNPLDG SVLLRNAVQA 120

DEGEYECRVS TFPAGSFQAR LRLRVLVPPL PSLNPGPALE EGQGLTLAAS CTAEGSPAPS 180

VTWDTEVKGT TSSRSFKHSR SAAVTSEFHL VPSRSMNGQP LTCWSHPGL LQDQRITHIL 240

HVSFLAEASV RGLEDQNLWH IGREGAMLKC LSEGQPPPSY NWTRLDGPLP SGVRVDGDTL 300

GFPPLTTEHS GIYVCHVSNE FSSRDSQVTV DVLDPQEDSG KQVDLVSASV VWGVIAALL 360

FCLLVWWL MSRYHRRKAQ QMTQKYEEEL TLTRENSIRR LHSHHTDPRS QPEESVGLRA 420

EGHPDSLKDN SSCSVMSEEP EGRSYSTLTT VREIETQTEL LSPGSGRAEE EEDQDEGIKQ 480 AMNHFVQENG TLRAKPTGNG IYINGRGHLV

Seq ID NO: 77 DNA sequence

Nucleic Acid Accession ft: NM_003474.2

Coding sequence: 37..3036

1 11 21 31 41 51

I I I

CACTAACGCT CTTCCTAGTC CCCGGGCCAA CTCGGACAGT TTGCTCATTT ATTGCAACGG 60 TCAAGGCTGG CTTGTGCCAG AACGGCGCGC GCGCGACGCA CGCACACACA CGGGGGGAAA 120 CTTTTTTAAA AATGAAAGGC TAGAAGAGCT CAGCGGCGGC GCGGGCCGTG CGCGAGGGCT 180 CCGGAGCTGA CTCGCCGAGG CAGGAAATCC CTCCGGTCGC GACGCCCGGC CCCGCTCGGC 240 GCCCGCGTGG GATGGTGCAG CGCTCGCCGC CGGGCCCGAG AGCTGCTGCA CTGAAGGCCG 300 GCGACGATGG CAGCGCGCCC GCTGCCCGTG TCCCCCGCCC GCGCCCTCCT GCTCGCCCTG 360 GCCGGTGCTC TGCTCGCGCC CTGCGAGGCC CGAGGGGTGA GCTTATGGAA CGAAGGAAGA 420 GCTGATGAAG TTGTCAGTGC CTCTGTTCGG AGTGGGGACC TCTGGATCCC AGTGAAGAGC 480 TTCGACTCCA AGAATCATCC AGAAGTGCTG AATATTCGAC TACAACGGGA AAGCAAAGAA 540 CTGATCATAA ATCTGGAAAG AAATGAAGGT CTCATTGCCA GCAGTTTCAC GGAAACCCAC 600 TATCTGCAAG ACGGTACTGA TGTCTCCCTC GCTCGAAATT ACACGGTAAT TCTGGGTCAC 660 TGTTACTACC ATGGACATGT ACGGGGATAT TCTGATTCAG CAGTCAGTCT CAGCACGTGT 720 TCTGGTCTCA GGGGACTTAT TGTGTTTGAA AATGAAAGCT ATGTCTTAGA ACCAATGAAA 780 AGTGCAACCA ACAGATACAA ACTCTTCCCA GCGAAGAAGC TGAAAAGCGT CCGGGGATCA 840 TGTGGATCAC ATCACAACAC ACCAAACCTC GCTGCAAAGA ATGTGTTTCC ACCACCCTCT 900 CAGACATGGG CAAGAAGGCA TAAAAGAGAG ACCCTCAAGG CAACTAAGTA TGTGGAGCTG 960 GTGATCGTGG CAGACAACCG AGAGTTTGAG AGGCAAGGAA AAGATCTGGA AAAAGTTAAG 1020 CAGCGATTAA TAGAGATTGC TAATCACGTT GACAAGTTTT ACAGACCACT GAACATTCGG 1080 ATCGTGTTGG TAGGCGTGGA AGTGTGGAAT GACATGGACA AATGCTCTGT AAGTCAGGAC 1140 CCATTCACCA GCCTCCATGA ATTTCTGGAC TGGAGGAAGA TGAAGCTTCT ACCTCGCAAA 1200 TCCCATGACA ATGCGCAGCT TGTCAGTGGG GTTTATTTCC AAGGGACCAC CATCGGCATG 1260 GCCCCAATCA TGAGCATGTG CACGGCAGAC CAGTCTGGGG GAATTGTCAT GGACCATTCA 1320 GACAATCCCC TTGGTGCAGC CGTGACCCTG GCACATGAGC TGGGCCACAA TTTCGGGATG 1380 AATCATGACA CACTGGACAG GGGCTGTAGC TGTCAAATGG CGGTTGAGAA AGGAGGCTGC 1440 ATCATGAACG CTTCCACCGG GTACCCATTT CCCATGGTGT TCAGCAGTTG CAGCAGGAAG 1500 GACTTGGAGA CCAGCCTGGA GAAAGGAATG GGGGTGTGCC TGTTTAACCT GCCGGAAGTC 1560 AGGGAGTCTT TCGGGGGCCA GAAGTGTGGG AACAGATTTG TGGAAGAAGG AGAGGAGTGT 1620 GACTGTGGGG AGCCAGAGGA ATGTATGAAT CGCTGCTGCA ATGCCACCAC CTGTACCCTG 1680 AAGCCGGACG CTGTGTGCGC ACATGGGCTG TGCTGTGAAG ACTGCCAGCT GAAGCCTGCA 1740 GGAACAGCGT GCAGGGACTC CAGCAACTCC TGTGACCTCC CAGAGTTCTG CACAGGGGCC 1800 AGCCCTCACT GCCCAGCCAA CGTGTACCTG CACGATGGGC ACTCATGTCA GGATGTGGAC 1860 GGCTACTGCT ACAATGGCAT CTGCCAGACT CACGAGCAGC AGTGTGTCAC ACTCTGGGGA 1920 CCAGGTGCTA AACCTGCCCC TGGGATCTGC TTTGAGAGAG TCAATTCTGC AGGTGATCCT 1980 TATGGCAACT GTGGCAAAGT CTCGAAGAGT TCCTTTGCCA AATGCGAGAT GAGAGATGCT 2040 AAATGTGGAA AAATCCAGTG TCAAGGAGGT GCCAGCCGGC CAGTCATTGG TACCAATGCC 2100 GTTTCCATAG AAACAAACAT CCCCCTGCAG CAAGGAGGCC GGATTCTGTG CCGGGGGACC 2160 CACGTGTACT TGGGCGATGA CATGCCGGAC CCAGGGCTTG TGCTTGCAGG CACAAAGTGT 2220 GCAGATGGAA AAATCTGCCT GAATCGTCAA TGTCAAAATA TTAGTGTCTT TGGGGTTCAC 2280 GAGTGTGCAA TGCAGTGCCA CGGCAGAGGG GTGTGCAACA ACAGGAAGAA CTGCCACTGC 2340 GAGGCCCACT GGGCACCTCC CTTCTGTGAC AAGTTTGGCT TTGGAGGAAG CACAGACAGC 2400 GGCCCCATCC GGCAAGCAGA TAACCAAGGT TTAACCATAG GAATTCTGGT GACCATCCTG 2460

TGTCTTCTTG CTGCCGGATT TGTGGTTTAT CTCAAAAGGA AGACCTTGAT ACGACTGCTG 2520

TTTACAAATA AGAAGACCAC CATTGAAAAA CTAAGGTGTG TGCGCCCTTC CCGGCCACCC 2580

CGTGGCTTCC AACCCTGTCA GGCTCACCTC GGCCACCTTG GAAAAGGCCT GATGAGGAAG 2640

5 CCGCCAGATT CCTACCCACC GAAGGACAAT CCCAGGAGAT TGCTGCAGTG TCAGAATGTT 2700

GACATCAGCA GACCCCTCAA CGGCCTGAAT GTCCCTCAGC CCCAGTCAAC TCAGCGAGTG 2760

CTTCCTCCCC TCCACCGGGC CCCACGTGCA CCTAGCGTCC CTGCCAGACC CCTGCCAGCC 2820

AAGCCTGCAC TTAGGCAGGC CCAGGGGACC TGTAAGCCAA ACCCCCCTCA GAAGCCTCTG 2880

CCTGCAGATC CTCTGGCCAG AACAACTCGG CTCACTCATG CCTTGGCCAG GACCCCAGGA 2940 0 CAATGGGAGA CTGGGCTCCG CCTGGCACCC CTCAGACCTG CTCCACAATA TCCACACCAA 3000

GTGCCCAGAT CCACCCACAC CGCCTATATT AAGTGAGAAG CCGACACCTT TTTTCAACAG 3060

TGAAGACAGA AGTTTGCACT ATCTTTCAGC TCCAGTTGGA GTTTTTTGTA CCAACTTTTA 3120

GGATTTTTTT TAATGTTTAA AACATCATTA CTATAAGAAC TTTGAGCTAC TGCCGTCAGT 3180

GCTGTGCTGT GCTATGGTGC TCTGTCTACT TGCACAGGTA CTTGTAAATT ATTAATTTAT 3240

15 GCAGAATGTT GATTACAGTG CAGTGCGCTG TAGTAGGCAT TTTTACCATC ACTGAGTTTT 3300

CCATGGCAGG AAGGCTTGTT GTGCTTTTAG TATTTTAGTG AACTTGAAAT ATCCTGCTTG 3360

ATGGGATTCT GGACAGGATG TGTTTGCTTT CTGATCAAGG CCTTATTGGA AAGCAGTCCC 3420

CCAACTACCC CCAGCTGTGC TTATGGTACC AGATGCAGCT CAAGAGATCC CAAGTAGAAT 3480

CTCAGTTGAT TTTCTGGATT CCCCATCTCA GGCCAGAGCC AAGGGGCTTC AGGTCCAGGC 3540 0 TGTGTTTGGC TTTCAGGGAG GCCCTGTGCC CCTTGACAAC TGGCAGGCAG GCTCCCAGGG 3600

ACACCTGGGA GAAATCTGGC TTCTGGCCAG GAAGCTTTGG TGAGAACCTG GGTTGCAGAC 3660

AGGAATCTTA AGGTGTAGCC ACACCAGGAT AGAGACTGGA ACACTAGACA AGCCAGAACT 3720

TGACCCTGAG CTGACCAGCC GTGAGCATGT TTGGAAGGGG TCTGTAGTGT CACTCAAGGC 3780

GGTGCTTGAT AGAAATGCCA AGCACTTCTT TTTCTCGCTG TCCTTTCTAG AGCACTGCCA 3840 5 CCAGTAGGTT ATTTAGCTTG GGAAAGGTGG TGTTTCTGTA AGAAACCTAC TGCCCAGGCA 3900

CTGCAAACCG CCACCTCCCT ATACTGCTTG .AGCTGAGCA AATCACCACA AACTGTAATA 3960

CAATGATCCT GTATTCAGAC AGATGAGGAC TTTCCATGGG ACCACAACTA TTTTCAGATG 4020

TGAACCATTA ACCAGATCTA GTCAATCAAG TCTGTTTACT GCAAGGTTCA ACTTATTAAC 4080

AATTAGGCAG ACTCTTTATG CTTGCAAAAA CTACAACCAA TGGAATGTGA TGTTCATGGG 4140 0 TATAGTTCAT GTCTGCTATC ATTATTCGTA GATATTGGAC AAAGAACCTT CTCTATGGGG 4200

CATCCTCTTT TTCCAACTTG GCTGCAGGAA TCTTTAAAAG ATGCTTTTAA CAGAGTCTGA 4260

ACCTATTTCT TAAACACTTG CAACCTACCT GTTGAGCATC ACAGAATGTG ATAAGGAAAT 4320

CAACTTGCTT ATCAACTTCC TAAATATTAT GAGATGTGGC TTGGGCAGCA TCCCCTTGAA 4380

CTCTTCACTC TTCAAATGCC TGACTAGGGA GCCATGTTTC ACAAGGTCTT TAAAGTGACT 4440 5 AATGGCATGA GAAATACAAA AATACTCAGA TAAGGTAAAA TGCCATGATG CCTCTGTCTT 4500

CTGGACTGGT TTTCACATTA GAAGACAATT GACAACAGTT ACATAATTCA CTCTGAGTGT 4560

TTTATGAGAA AGCCTTCTTT TGGGGTCAAC AGTTTTCCTA TGCTTTGAAA CAGAAAAATA 4620

TGTACCAAGA ATCTTGGTTT GCCTTCCAGA AAACAAAACT GCATTTCACT TTCCCGGTGT 4680

TCCCCACTGT ATCTAGGCAA CA AGTATTC ATGACTATGG ATAAACTAAA CACGTGACAC 4740 0 AAACACACAC AAAAGGGAAC CCAGCTCTAA TACATTCCAA CTCGTATAGC ATGCATCTGT 4800

TTATTCTATA GTTATTAAGT TCTTTAAAAT GTAAAGCCAT GCTGGAAAAT AATACTGCTG 4860

AGATACATAC AGAATTACTG TAACTGATTA CACTTGGTAA TTGTACTAAA GCCAAACATA 4920

TATATACTAT TAAAAAGGTT TACAGAATTT TATGGTGCAT TACGTGGGCA TTGTCTTTTT 4980

AGATGCCCAA ATCCTTAGAT CTGGCATGTT AGCCCTTCCT CCAATTATAA GAGGATATGA 5040 5 ACCAAAAAAA AAAAAAAAAA AA

Seq ID NO: 78 Protein sequence Protein Accession ft: NP_003465 1 11 21 31 41 51 0 i i i i I i

MAARPLPVSP ARALLLALAG ALLAPCEARG VSL NEGRAD EWSASVRSG DLWIPVKSFD 60

SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL QDGTDVSLAR NYTVILGHCY 120

YHGHVRGYSD SAVSLSTCSG LRGLIVFENE SYVLEPMKSA TNRYKLFPAK KLKSVRGSCG 180

SHHNTPNLAA KNVFPPPSQT WARRHKRETL KATKYVELVI VADNREFQRQ GKDLEKVKQR 240 5 LIEIANHVDK FYRPLNIRIV LVGVEWJNDM DKCSVSQDPF TSLHEFLDWR KMKLLPRKSH 300

DNAQLVSGVY FQGTTIGMAP IMSMCTADQS GGIVMDHSDN P GAAVTLAH ELGHNFGMNH 360

DTLDRGCSCQ MAVEKGGCIM NASTGYPFPM VFSSCSRKDL ETSLEKGMGV CLFNLPEVRE 420

SFGGQKCGNR FVEEGEECDC GEPEECMNRC CNATTCTLKP DAVCAHGLCC EDCQLKPAGT 480

ACRDSSNSCD LPEFCTGASP HCPANVYLHD GHSCQDVDGY CYNGICQTHE QQCVTLWGPG 540 0 AKPAPGICFE RVNSAGDPYG NCGKVSKSSF AKCEMRDAKC GKIQCQGGAS RPVIGTNAVS 600

IETNIPLQQG GRILCRGTHV YLGDDMPDPG LVLAGTKCAD GKICLNRQCQ NISVFGVHEC 660

AMQCHGRGVC NNRKNCHCEA H APPFCDKF GFGGSTDSGP IRQADNQGLT IGILVTILCL 720

LAAGFWYLK RKTLIRLLFT NKKTTIEKLR CVRPSRPPRG FQPCQAHLGH LGKGLMRKPP 780

DSYPPKDNPR RLLQCQNVDI SRPLNGLNVP QPQSTQRVLP PLHRAPRAPS VPARPLPAKP 840 5 ALRQAQGTCK PNPPQKPLPA DPLARTTRLT HALARTPGQW ETGLRLAPLR PAPQYPHQVP 900 RSTHTAYIK

Seq ID NO: 79 DNA sequence Nucleic Acid Accession ft: NM_003714 /U Coding sequence: 135..1043

1 11 21 31 41 51

I I I I I I

GAGGAGGAGG GAAAAGGCGA GCAAAAAGGA AGAGTGGGAG GAGGAGGGGA AGCGGCGAAG 60

GAGGAAGAGG AGGAGGAGGA AGAGGGGAGC ACAAAGGATC CAGGTCTCCC GACGGGAGGT 120

75 TAATACCAAG AACCATGTGT GCCGAGCGGC TGGGCCAGTT CATGACCCTG GCTTTGGTGT 180

TGGCCACCTT TGACCCGGCG CGGGGGACCG ACGCCACCAA CCCACCCGAG GGTCCCCAAG 240'

ACAGGAGCTC CCAGCAGAAA GGCCGCCTGT CCCTGCAGAA TACAGCGGAG ATCCAGCACT 300

GTTTGGTCAA CGCTGGCGAT GTGGGGTGTG GCGTGTTTGA ATGTTTCGAG AACAACTCTT 360

__A GTGAGATTCG GGGCTTACAT GGGATTTGCA TGACTTTTCT GCACAACGCT GGAAAATTTG 420

80 ATGCCCAGGG CAAGTCATTC ATCAAAGACG CCTTGAAATG TAAGGCCCAC GCTCTGCGGC 480

ACAGGTTCGG CTGCATAAGC CGGAAGTGCC CGGCCATCAG GGAAATGGTG TCCCAGTTGC 540

AGCGGGAATG CTACCTCAAG CACGACCTGT GCGCGGCTGC CCAGGAGAAC ACCCGGGTGA 600

TAQTGGAGAT GATCCATTTC AAGGACTTGC TGCTGCACGA ACCCTACGTG GACCTCGTGA 660

ACTTGCTGCT GACCTGTGGG GAGGAGGTGA AGGAGGCCAT CACCCACAGC GTGCAGGTTC 720

85 AGTGTGAGCA GAACTGGGGA AGCCTGTGCT CCATCTTGAG CTTCTGCACC TCGGCCATCC 780 AGAAGCCTCC CACGGCGCCC CCCGAGCGCC AGCCCCAGGT GGACAGAACC AAGCTCTCCA 840 GGGCCCACCA CGGGGAAGCA GGACATCACC TCCCAGAGCC CAGCAGTAGG GAGACTGGCC 900 GAGGTGCCAA GGGTGAGCGA GGTAGCAAGA GCCACCCAAA CGCCCATGCC CGAGGCAGAG 960 TCGGGGGCCT TGGGGCTCAG GGACCTTCCG GAAGCAGCGA GTGGGAAGAC GAACAGTCTG 1020 AGTATTCTGA TATCCGGAGG TGAAATGAAA GGCCTGGCCA CGAAATCTTT CCTCCACGCC 1080 GTCCATTTTC TTATCTATGG ACATTCCAAA ACATTTACCA TTAGAGAGGG GGGATGTCAC 1140 ACGCAGGATT CTGTGGGGAC TGTGGACTTC ATCGAGGTGT GTGTTCGCGG AACGGACAGG 1200 TGAGATGGAG ACCCCTGGGG CCGTGGGGTC TCAGGGGTGC CTGGTGAATT CTGCACTTAC 1260 ACGTACTCAA GGGAGCGCGC CCGCGTTATC CTCGTACCTT TGTCTTCTTT CCATCTGTGG 1320 AGTCAGTGGG TGTCGGCCGC TCTGTTGTGG GGGAGGTGAA CCAGGGAGGG GCAGGGCAAG 1380 GCAGGGCCCC CAGAGCTGGG CCACACAGTG GGTGCTGGGC CTCGCCCCGA AGCTTCTGGT 1440 GCAGCAGCCT CTGGTGCTGT CTCCGCGGAA GTCAGGGCGG CTGGATTCCA GGACAGGAGT 1500 GAATGTAAAA ATAAATATCG CTTAGAATGC AGGAGAAGGG TGGAGAGGAG GCAGGGGCCG 1560 AGGGGGTGCT TGGTGCCAAA CTGAAATTCA GTTTCTTGTG TGGGGCCTTG CGGTTCAGAG 1620 CTCTTGGCGA GGGTGGAGGG AGGAGTGTCA TTTCTATGTG TAATTTCTGA GCCATTGTAC 1680 TGTCTGGGCT GGGGGGGACA CTGTCCAAGG GAGTGGCCCC TATGAGTTTA TATTTTAACC 1740 ACTGCTTCAA ATCTCGATTT CACTTTTTTT ATTTATCCAG TTATATCTAC ATATCTGTCA 1800 TCTAAATAAA TGGCTTTCAA ACAAAGCAAC TGGGTCATTA AAACCAGCTC AAAGGGGGTT 1860 TAAAAAAAAA AAAACCAGCC CATCCTTTGA GGCTGATTTT TCTTTTTTTT AAGTTCTATT 1920 TTAAAAGCTA TCAAACAGCG ACATAGCCAT ACATCTGACT GCCTGACATG GACTCCTGCC 1980 CACTTGGGGG AAACCTTATA CCCAGAGGAA AATACACACC TGGGGAGTAC ATTTGACAAA 2040 TTTCCCTTAG GATTTCGTTA TCTCACCTTG ACCCTCAGCC AAGATTGGTA AAGCTGCGTC 2100 CTGGCGATTC CAGGAGACCC AGCTGGAAAC CTGGCTTCTC CATGTGAGGG GATGGGAAAG 2160 GAAAGAAGAG AATGAAGACT ACTTAGTAAT TCCCATCAGG AAATGCTGAC CTTTTACATA 2220 AAATCAAGGA GACTGCTGAA AATCTCTAAG GGACAGGATT TTCCAGATCC TAATTGGAAA 2280 TTTAGCAATA AGGAGAGGAG TCCAAGGGGA CAAATAAAGG CAGAGAGAGA GAGAGAGAGA 2340 GGGAGAGGAA GAAAAGAGAG AGAGAAAAGA GCCTCGTGCC

Seq ID NO: 80 Protein sequence Protein Accession ft: NP_003705

1 11 21 31 41 51

I I I I I I

MCAERLGQFM TLALVLATFD PARGTDATNP PEGPQDRSSQ QKGRLSLQNT AEIQHCLVNA 60

GDVGCGVFEC FENNSCEIRG LHGICMTFLH NAGKFDAQGK SFIKDALKCK AHALRHRFGC 120

ISRKCPAIRE MVSQLQRECY LKHDLCAAAQ ENTRVIVEMI HFKDLLLHEP YVDLVNLLLT 180

CGEEVKEAIT HSVQVQCEQN GSLCSILSF CTSAIQKPPT APPERQPQVD RTKLSRAHHG 240

EAGHHLPEPS SRETGRGAKG ERGSKSHPNA HARGRVGGLG AQGPSGSSEW EDEQSEYSDI 300 RR

Seq ID NO: 81 DNA sequence

Nucleic Acid Accession ft: CAT cluster

1 11 21 31 51

I I I I

AATCATGTTT TTGGAATAAA AATGGTAAAT GTTTTTTTTT TTTTTTTTTT GTTAGTAATG 60 GAAGTATTCT ATTATTTTTA ATTTTATGTA TGTACAGACA AGAGCTATAT GGGAAAGTAG 120 CTATTACAGA CCCATTATAG TTTCATCATT TATAACCAGG GTTGGTAGTA AAGCAACAGA 180 AATACATCTT CAATGCAGAC TTGCTCCCAG CATCTCTTTC CTTTCATCCT TGACCATATT 240 GCATCCTGGA CAGGAAGAAG ACATCCTCAG CCCACCACCC CTTCCCCTCC AATGTGGACT 300 GAGTGTTGGG TCAACTGATA AGCAGTGCAG ACTCTTCATT TTGCTTTGTT GGTGCCTTGG 360^' AGGCATGTGA GGGCACAGCC TCAAATTCCA GAGACCTTGC CTTCAGGATT TGAGGTGGGC 420 AAAGATGTGA AAGAAGACCT TTAGCCACTC AGTGTTATCA AAAGCAATCA CCAAAGAAGT 480 TTTTGCATCT GGCATTGTGT TGGGACGTCC ATCAGCAGTA CCGTACGGTC TCTTTACTGG 540 ACAAGTATTT ACACCTTGTT AACAGCAGTG TACACCCGGT GGAAAACTCC TATCTAATGG 600 CATGGCAGAA TTGTAAACAT TTCCTCCTTC ACCAAATTTG TGGATGGAAT AAACATGTAG 660 CCTTAAACTT TATTGGCTTC TCCGGTCTTG CCACTGCGGG GCCCAAAAAC TTTCAGAAGT 720 AGGAATCCTG TGGCATCTGC TAATGGTGAT TGGAAGAAAG AGTAGAGGTG ACAGTATCTA 780 TGGGTGCAGT ACCAGAACTA TTACGAAATG TTCCAGCTGC GATTTCAGAG GAATCCCCCC 840 TGACCCCTGG ACGTGGTTCT CCTATTTCAG TCACCCTGTG CCG

Seq ID NO: 82 DNA sequence Nucleic Acid Accession ft: XM_0610 91.1 Coding sequence: 1..2481 1 11 21 31 41 51

I I 1

ATGCCAAATA CTTCAGGAAC AACCAGGATT GAAATTTGGC TTCTCCAAGA GCCGCCCGGG 60 CACCGAGCGC TGGTCGCCGC TCTCCTTCCG GTGAGTCCCA GCCCCGAGTT GGCTCTGGCG 120 CCCGGGTACC CGCCAGTGCC GGCTGCCGAT GACCGATTCA CGCTCCCGAT GATTGGAGGT 180 CAGATGCATG GTGAGAAGGT AGATCTCTGG AGCCTTGGTG TTCTTTGCTA TGAATTTTTA 240 GTTGGGAAGC CTCCTTTTGA GGCAAACGAA GTCCATGTAA GCAAAGAAAC CATCGGGAAG 300 ATTTCAGCTG CCAGCAAAAT GATGTGGTGC TCGGCTGCAG TGGACATCAT GTTTCTGTTA 360 GATGGGTCTA ACAGCGTCGG GAAAGGGAGC TTTGAAAGGT CCAAGCACTT TGCCATCACA 420 GTCTGTGACG GTCTGGACAT CAGCCCCGAG AGGGTCAGAG TGGGAGCATT CCAGTTCAGT 480 TCCACTCCTC ATCTGGAATT CCCCTTGGAT TCATTTTCAA CCCAACAGGA AGTGAAGGCA 540 AGAATCAAGA GGATGGTTTT CAAAGGAGGG CGCACGGAGA CGGAACTTGC TCTGAAATAC 600 CTTCTGCACA GAGGGTTGCC TGGAGGCAGA AATGCTTCTG TGCCCCAGAT CCTCATCATC 660 GTCACTGATG GGAAGTCCCA GGGGGATGTG GCACTGCCAT CCAAGCAGCT GAAGGAAAGG 720 GGTGTCACTG TGTTTGCTGT GGGGGTCAGG TTTCCCAGGT GGGAGGAGCT GCATGCACTG 780 GCCAGCGAGC CTAGAGGGCA GCACGTGCTG TTGGCTGAGC AGGTGGAGGA TGCCACCAAC 840 GGCCTCTTCA GCACCCTCAG CAGCTCGGCC ATCTGCTCCA GCGCCACGCC AGCTGGGAGC 900 CCCGAGCTTG TCTTCATGGA GCGGTTAATG GGCATCTCTC TGATAGGCCC CTGTGACTCG 960 CAGCCCTGCC AGAATGGAGG CACATGTGTT CCAGAAGGAC TGGACGGCTA CCAGTGCCTC 1020 TGCCCGCTGG CCTTTGGAGG GGAGGCTAAC TGTGCCCTGA AGCTGAGCCT GGAATGCAGG 1080 GTCGACCTCC TCTTCCTGCT GGACAGCTCT GCGGGCACCA CTCTGGACGG CTTCCTGCGG 1140 GCCAAAGTCT TCGTGAAGCG GTTTGTGCGG GCCGTGCTGA GCGAGGACTC TCGGGCCCGA 1200 GTGGGTGTGG CCACATACAG CAGGGAGCTG CTGGTGGCGG TGCCTGTGGG GGAGTACCAG 1260 GATGTGCCTG ACCTGGTCTG GAGCCTCGAT GGCATTCCCT TCCGTGGTGG CCCCACCCTG 1320 ACGGGCAGTG CCTTGCGGCA GGCGGCAGAG CGTGGCTTCG GGAGCGCCAC CAGGACAGGC 1380 CAGGACCGGC CACGTAGAGT GGTGGTTTTG CTCACTGAGT CACACTCCGA GGATGAGGTT 1440 GCGGGCCCAG CGCGTCACGC AAGGGCGCGA GAGCTGCTCC TGCTGGGTGT AGGCAGTGAG 1500 GCCGTGCGGG CAGAGCTGGA GGAGATCACA GGCAGCCCAA AGCATGTGAT GGTCTACTCG 1S60 GATCCTCAGG ATCTGTTCAA CCAAATCCCT GAGCTGCAGG GGAAGCTGTβ CAGCCGGCAG 1620 CGGCCAGGGT GCCGGACACA AGCCCTGGAC CTCGTCTTCA TGTTGGACAC CTCTGCCTCA 1680 GTAGGGCCCG AGAATTTTGC TCAGATGCAG AGCTTTGTGA GAAGCTGTGC CCTCCAGTTT 1740 GAGGTGAACC CTGACGTGAC ACAGGTCGGC CTGGTGGTGT ATGGCAGCCA GGTGCAGACT 1800 GCCTTCGGGC TGGACACCAA ACCCACCCGG GCTGCGATGC TGCGGGCCAT TAGCCAGGCC 1860 CCCTACCTAG GTGGGGTGGG CTCAGCCGGC ACCGCCCTGC TGCACATCTA TGACAAAGTG 1920 ATGACCGTCC AGAGGGGTGC CCGGCCTGGT GTCCCCAAAG CTGTGGTGGT GCTCACAGGC 1980 GGGAGAGGCG CAGAGGATGC AGCCGTTCCT GCCCAGAAGC TGAGGAACAA TGGCATCTCT 2040 GTCTTGGTCG TGGGCGTGGG GCCTGTCCTA AGTGAGGGTC TGCGGAGGCT TGCAGGTCCC 2100 CGGGATTCCC TGATCCACGT GGCAGCTTAC GCCGACCTGC GGTACCACCA GGACGTGCTC 2160 ATTGAGTGGC TGTGTGGAGA AGCCAAGCAG CCAGTCAACC TCTGCAAACC CAGCCCGTGC 2220 ATGAATGAGG GCAGCTGCGT CCTGCAGAAT GGGAGCTACC GCTGCAAGTG TCGGGATGGC 2280 TGGGAGGGCC CCCACTGCGA GAACCGTGAG TGGAGCTCTT GCTCTGTATG TGTGAGCCAG 2340 GGATGGATTC TTGAGACGCC CCTGAGGCAC ATGGCTCCCG TGCAGGAGGG CAGCAGCCGT 2400 ACCCCTCCCA GCAACTACAG AGAAGGCCTG GGCACTGAAA TGGTGCCTAC CTTCTGGAAT 2460 GTCTGTGCCC CAGGTCCTTA G

Seq ID NO : 83 Protein sequence Protein Accession ft : XP_061091.1

1 11 21 31 SI

I I I

MPNTSGTTRI EI LLQEPPG HRALVAALLP VSPSPELALA PGYPPVPAAD DRFTLPMIGG 60

QMHGEKVDL SLGVLCYEFL VGKPPFEANE VHVSKETIGK ISAASKMMWC SAAVDIMFLL 120

DGSNSVGKGS FERSKHFAIT VCDGLDISPE RVRVGAFQFS STPHLEFPLD SFSTQQEVKA 180

RIKRMVFKGG RTETELALKY LLHRGLPGGR NASVPQILII VTDGKSQGDV ALPSKQLKER 240

GVTVFAVGVR FPRWEELHAL ASEPRGQHVL LAEQVEDATN GLFSTLSSSA ICSSATPAGS 300

PELVFMERLM GISLIGPCDS QPCQNGGTCV PEGLDGYQCL CPLAFGGEAN CALKLSLECR 360

VDLLFLLDSS AGTTLDGFLR AKVFVKREVR AVLSEDSRAR VGVATYSREL LVAVPVGEYQ 420

DVPDLVWSLD GIPFRGGPTL TGSALRQAAE RGFGSATRTG QDRPRRVWL LTESHSEDEV 480

AGPARHARAR ELLLLGVGSE AVRAELEEIT GSPKHVMVYS DPQDLFNQIP ELQGKLCSRQ 540

RPGCRTQALD LVFMLDTSAS VGPENFAQMQ SFVRSCALQF EVNPDVTQVG LWYGSQVQT 600

AFGLDTKPTR AAMLRAISQA PYLGGVGSAG TALLHIYDKV MTVQRGARPG VPKAVWLTG 660

GRGAEDAAVP AQKLRNNGIS VLWGVGPVL SEGLRRLAGP RDSLIHVAAY ADLRYHQDVL 720

IEWLCGEAKQ PVNLCKPSPC MNEGSCVLQN GSYRCKCRDG EGPHCENRE WSSCSVCVSQ 780

G ILETPLRH MAPVQEGSSR TPPSNYREGL GTEMVPTF N VCAPGP

Seq ID NO : 84 DNA sequence

Nucleic Acid Accession ft : Eos sequence

Coding sequence : 1. .2424

1 11 21 31

I I 1 I

ATGCCCCCTT TCCTGTTGCT GGAGGCCGTC TGTGTTTTCC TGTTTTCCAG AGTGCCCCCA 60 TCTCTCCCTC TCCAGGAAGT CCATGTAAGC AAAGAAACCA TCGGGAAGAT TTCAGCTGCC 120 AGCAAAATGA TGTGGTGCTC GGCTGCAGTG GACATCATGT TTCTGTTAGA TGGGTCTAAC 180 AGCGTCGGGA AAGGGAGCTT TGAAAGGTCC AAGCACTTTG CCATCACAGT CTGTGACGGT 240 CTGGACATCA GCCCCGAGAG GGTCAGAGTG GGAGCATTCC AGTTCAGTTC CACTCCTCAT 300 CTGGAATTCC CCTTGGATTC ATTTTCAACC CAACAGGAAG TGAAGGCAAG AATCAAGAGG 360 ATGGTTTTCA AAGGAGGGCG CACGGAGACG GAACTTGCTC TGAAATACCT TCTGCACAGA 420 GGGTTGCCTG GAGGCAGAAA TGCTTCTGTG CCCCAGATCC TCATCATCGT CACTGATGGG 480 AAGTCCCAGG GGGATGTGGC ACTGCCATCC AAGCAGCTGA AGGAAAGGGG TGTCACTGTG 540 TTTGCTGTGG GGGTCAGGTT TCCCAGGTGG GAGGAGCTGC ATGCACTGGC CAGCGAGCCT 600 AGAGGGCAGC ACGTGCTGTT GGCTGAGCAG GTGGAGGATG CCACCAACGG CCTCTTCAGC 660 ACCCTCAGCA GCTCGGCCAT CTGCTCCAGC GCCACGCCAG ACTGCAGGGT CGAGGCTCAC 720 CCCTGTGAGC ACAGGACGCT GGAGATGGTC CGGGAGTTCG CTGGCAATGC CCCATGCTGG 780 AGAGGATCGC GGCGGACCCT TGCGGTGCTG GCTGCACACT GTCCCTTCTA CAGCTGGAAG 840 AGAGTGTTCC TAACCCACCC TGCCACCTGC TACAGGACCA CCTGCCCAGG CCCCTGTGAC 900 TCGCAGCCCT GCCAGAATGG AGGCACATGT GTTCCAGAAG GACTGGACGG CTACCAGTGC 960 CTCTGCCCGC TGGCCTTTGG AGGGGAGGCT AACTGTGCCC TGAAGCTGAG CCTGGAATGC 1020 AGGGTCGACC TCCTCTTCCT GCTGGACAGC TCTGCGGGCA CCACTCTGGA CGGCTTCCTG 1080 CGGGCCAAAG TCTTCGTGAA GCGGTTTGTG CGGGCCGTGC TGAGCGAGGA CTCTCGGGCC 1140 CGAGTGGGTG TGGCCACATA CAGCAGGGAG CTGCTGGTGG CGGTGCCTGT GGGGGAGTAC 1200 CAGGATGTGC CTGACCTGGT CTGGAGCCTC GATGGCATTC CCTTCCGTGG TGGCCCCACC 1260 CTGACGGGCA GTGCCTTGCG GCAGGCGGCA GAGCGTGGCT TCGGGAGCGC CACCAGGACA 1320 GGCCAGGACC GGCCACGTAG AGTGGTGGTT TTGCTCACTG AGTCACACTC CGAGGATGAG 1380 GTTGCGGGCC CAGCGCGTCA CGCAAGGGCG CGAGAGCTGC TCCTGCTGGG TGTAGGCAGT 1440 GAGGCCGTGC GGGCAGAGCT GGAGGAGATC ACAGGCAGCC CAAAGCATGT GATGGTCTAC 1500 TCGGATCCTC AGGATCTGTT CAACCAAATC CCTGAGCTGC AGGGGAAGCT GTGCAGCCGG 1560 CAGCGGCCAG GGTGCCGGAC ACAAGCCCTG GACCTCGTCT TCATGTTGGA CACCTCTGCC 1620 TCAGTAGGGC CCGAGAATTT TGCTCAGATG CAGAGCTTTG TGAGAAGCTG TGCCCTCCAG 1680 TTTGAGGTGA ACCCTGACGT GACACAGGTC GGCCTGGTGG TGTATGGCAG CCAGGTGCAG 1740 ACTGCCTTCG GGCTGGACAC CAAACCCACC CGGGCTGCGA TGCTGCGGGC CATTAGCCAG 1800 GCCCCCTACC TAGGTGGGGT GGGCTCAGCC GGCACCGCCC TGCTGCACAT CTATGACAAA 1860 GTGATGACCG TCCAGAGGGG TGCCCGGCCT GGTGTCCCCA AAGCTGTGGT GGTGCTCACA 1920 GGCGGGAGAG GCGCAGAGGA TGCAGCCGTT CCTGCCCAGA AGCTGAGGAA CAATGGCATC 1980 TCTGTCTTGG TCGTGGGCGT GGGGCCTGTC CTAAGTGAGG GTCTGCGGAG GCTTGCAGGT 2040 CCCCGGGATT CCCTGATCCA CGTGGCAGCT TACGCCGACC TGCGGTACCA CCAGGACGTG 2100 CTCATTGAGT GGCTGTGTGG AGAAGCCAAG CAGCCAGTCA ACCTCTGCAA ACCCAGCCCG 2160 TGCATGAATG AGGGCAGCTG CGTCCTGCAG AATGGGAGCT ACCGCTGCAA GTGTCGGGAT 2220 GGCTGGGAGG GCCCCCACTG CGAGAACCGT GAGTGGAGCT CTTGCTCTGT ATGTGTGAGC 2280 CAGGGATGGA TTCTTGAGAC GCCCCTGAGG CACATGGCTC CCGTGCAGGA GGGCAGCAGC 2340 CGTACCCCTC CCAGCAACTA CAGAGAAGGC CTGGGCACTG AAATGGTGCC TACCTTCTGG AATGTCTGTG CCCCAGGTCC TTAG

Seq ID NO : 85 Protein sequence Protein Accession ft : Eos sequence

1 11 21 31 SI

1 1 1 1

MPPFLLLEAV CVFLFSRVPP SLPLQEVHVS KETIGKISAA SKMMWCSAAV DIMFLLDGSN 60 SVGKGSFERS KHFAITVCDG LDISPERVRV GAFQFSSTPH LEFPLDSFST QQEVKARIKR 120 MVFKGGRTET ELALKYLLHR GLPGGRNASV PQILI IVTDG KSQGDVALPS KQLKERGVTV 180

FAVGVRFPRW EELHALASEP RGQHVLLAEQ VEDATNGLFS TLSΞSAICSS ATPDCRVEAH 240 PCEHRTLEMV REFAGNAPCW RGSRRTLAVL AAHCPFYS K RVFLTHPATC YRTTCPGPCD 300 SQPCQNGGTC VPEGLDGYQC LCPLAFGGEA NCALKLSLEC RVDLLFLLDS SAGTTLDGFL 360 RAKVFVKRFV RAVLSEDSRA RVGVATYSRE LLVAVPVGEY QDVPDLVWSL DGIPFRGGPT 420 LTGSALRQAA ERGFGSATRT GQDRPRRWV LLTESHSEDE VAGPARHARA RELLLLGVGS 480

EAVRAELEEI TGSPKHVMVY SDPQDLFNQI PELQGKLCSR QRPGCRTQAL DLVFMLDTSA 540 SVGPENFAQM QSFVRSCALQ FEVNPDVTQV GLWYGSQVQ TAFGLDTKPT RAAMLRAISQ 600 APYLGGVGSA GTALLHIYDK VMTVQRGARP GVPKA WLT GGRGAEDAAV PAQKLRNNGI 660 SVLWGVGPV LSEGLRRLAG PRDSLIHVAA YADLRYHQDV LIEWLCGEAK QPVNLCKPSP 720 CMNEGSCVLQ NGSYRCKCRD GWEGPHCENR EWSSCSVCVS QG ILETPLR HMAPVQEGSS 780

RTPPSNYREG LGTEMVPTFW NVCAPGP

Seq ID NO: 86 DNA sequence

Nucleic Acid Accession ft: Eos sequence

Coding sequence: 89..2356

1 11 21 31

I I I I

GCCCCCTGGC CCGAGCCGCG CCCGGGTCTG TGAGTAGAGC CGCCCGGGCA CCGAGCGCTG 60 GTCGCCGCTC TCCTTCCGTT ATATCAACAT GCCCCCTTTC CTGTTGCTGG AAGCCGTCTG 120 TGTTTTCCTG TTTTCCAGAG TGCCCCCATC TCTCCCTCTC CAGGAAGTCC ATGTAAGCAA 180 AGAAACCATC GGGAAGATTT CAGCTGCCAG CAAAATGATG TGGTGCTCGG CTGCAGTGGA 240 CATCATGTTT CTGTTAGATG GGTCTAACAG CGTCGGGAAA GGGAGCTTTG AAAGGTCCAA 300 GCACTTTGCC ATCACAGTCT GTGACGGTCT GGACATCAGC CCCGAGAGGG TCAGAGTGGG 360 AGCATTCCAG TTCAGTTCCA CTCCTCATCT GGAATTCCCC TTGGATTCAT TTTCAACCCA 420 ACAGGAAGTG AAGGCAAGAA TCAAGAGGAT GGTTTTCAAA GGAGGGCGCA CGGAGACGGA 480 ACTTGCTCTG AAATACCTTC TGCACAGAGG GTTGCCTGGA GGCAGAAATG CTTCTGTGCC 540 CCAGATCCTC ATCATCGTCA CTGATGGGAA GTCCCAGGGG GATGTGGCAC TGCCATCCAA 600 GCAGCTGAAG GAAAGGGGTG TCACTGTGTT TGCTGTGGGG GTCAGGTTTC CCAGGTGGGA 660 GGAGCTGCAT GCACTGGCCA GCGAGCCTAG AGGGCAGCAC GTGCTGTTGG CTGAGCAGGT 720 GGAGGATGCC ACCAACGGCC TCTTCAGCAC CCTCAGCAGC TCGGCCATCT GCTCCAGCGC 780 CACGCCAGAC TGCAGGGTCG AGGCTCACCC CTGTGAGCAC AGGACGCTGG AGATGGTCCG 840 GGAGTTCGCT GGCAATGCCC CATGCTGGAG AGGATCGCGG CGGACCCTTG CGGTGCTGGC 900 TGCACACTGT CCCTTCTACA GCTGGAAGAG AGTGTTCCTA ACCCACCCTG CCACCTGCTA 960 CAGGACCACC TGCCCAGGCC CCTGTGACTC GCAGCCCTGC CAGAATGGAG GCACATGTGT 1020 TCCAGAAGGA CTGGACGGCT ACCAGTGCCT CTGCCCGCTG GCCTTTGGAG GGGAGGCTAA 1080 CTGTGCCCTG AAGCTGAGCC TGGAATGCAG GGTCGACCTC CTCTTCCTGC TGGACAGCTC 1140 TGCGGGCACC ACTCTGGACG GCTTCCTGCG GGCCAAAGTC TTCGTGAAGC GGTTTGTGCG 1200 GGCCGTGCTG AGCGAGGACT CTCGGGCCCG AGTGGGTGTG GCCACATACA GCAGGGAGCT 1260 GCTGGTGGCG GTGCCTGTGG GGGAGTACCA GGATGTGCCT GACCTGGTCT GGAGCCTCGA 1320 TGGCATTCCC TTCCGTGGTG GCCCCACCCT GACGGGCAGT GCCTTGCGGC AGGCGGCAGA 1380 GCGTGGCTTC GGGAGCGCCA CCAGGACAGG CCAGGACCGG CCACGTAGAG TGGTGGTTTT 1440 GCTCACTGAG TCACACTCCG AGGATGAGGT TGCGGGCCCA GCGCGTCACG CAAGGGCGCG 1500 AGAGCTGCTC CTGCTGGGTG TAGGCAGTGA GGCCGTGCGG GCAGAGCTGG AGGAGATCAC 1560 AGGCAGCCCA AAGCATGTGA TGGTCTACTC GGATCCTCAG GATCTGTTCA ACCAAATCCC 1620 TGAGCTGCAG GGGAAGCTGT GCAGCCGGCA GCGGCCAGGG TGCCGGACAC AAGCCCTGGA 1680 CCTCGTCTTC ATGTTGGACA CCTCTGCCTC AGTAGGGCCC GAGAATTTTG CTCAGATGCA 1740 GAGCTTTGTG AGAAGCTGTG CCCTCCAGTT TGAGGTGAAC CCTGACGTGA CACAGGTCGG 1800 CCTGGTGGTG TATGGCAGCC AGGTGCAGAC TGCCTTCGGG CTGGACACCA AACCCACCCG 1860 GGCTGCGATG CTGCGGGCCA TTAGCCAGGC CCCCTACCTA GGTGGGGTGG GCTCAGCCGG 1920 CACCGCCCTG CTGCACATCT ATGACAAAGT GATGACCGTC CAGAGGGGTG CCCGGCCTGG 1980 TGTCCCCAAA GCTGTGGTGG TGCTCACAGG CGGGAGAGGC GCAGAGGATG CAGCCGTTCC 2040 TGCCCAGAAG CTGAGGAACA ATGGCATCTC TGTCTTGGTC GTGGGCGTGG GGCCTGTCCT 2100 AAGTGAGGGT CTGCGGAGGC TTGCAGGTCC CCGGGATTCC CTGATCCACG TGGCAGCTTA 2160 CGCCGACCTG CGGTACCACC AGGACGTGCT CATTGAGTGG CTGTGTGGAG AAGCCAAGCA 2220 GCCAGTCAAC CTCTGCAAAC CCAGCCCGTG CATGAATGAG GGCAGCTGCG TCCTGCAGAA 2280 TGGGAGCTAC CGCTGCAAGT GTCGGGATGG CTGGGAGGGC CCCCACTGCG AGAACCGATT 2340 CTTGAGACGC CCCTGAGGCA CATGGCTCCC GTGCAGGAGG GCAGCAGCCG TACCCCTCCC 2400 AGCAACTACA GAGAAGGCCT GGGCACTGAA ATGGTGCCTA CCTTCTGGAA TGTCTGTGCC 2460 CCAGGTCCTT AGAATGTCTG CTTCCCGCCG TGGCCAGGAC CACTATTCTC ACTGAGGGAG 2520 GAGGATGTCC CAACTGCAGC CATGCTGCTT AGAGACAAGA AAGCAGCTGA TGTCACCCAC 2580 AAACGATGTT GTTGAAAAGT TTTGATGTGT AAGTAAATAC CCACTTTCTG TACCTGCTGT 2640 GCCTTGTTGA GGCTATGTCA TCTGCCACCT TTCCCTTGAG GATAAACAAG GGGTCCTGAA 2700 GACTTAAATT TAGCGGCCTG ACGTTCCTTT GCACACAATC AATGCTCGCC AGAATGTTGT 2760 TGACACAGTA ATGCCCAGCA GAGGCCTTTA CTAGAGCATC CTTTGGACGG

Seq ID NO: 87 Protein sequence Protein Accession ft: Eos sequence 1 11 21 31

I I 1 I

MPPFLLLEAV CVFLFSRVPP SLPLQEVHVS KETIGKISAA SKMMWCSAAV DIMFLLDGSN 60 SVGKGSFERS KHFAITVCDG LDISPERVRV GAFQFSSTPH LEFPLDSFST QQEVKARIKR 120 MVFKGGRTET ELALKYLLHR GLPGGRNASV PQILIIVTDG KSQGDVALPS KQLKERGVTV 180 FAVGVRFPRW EELHALASEP RGQHVLLAEQ VEDATNGLFS TLSSSAICSS ATPDCRVEAH 240 PCEHRTLEMV REFAGNAPCW RGSRRTLAVL AAHCPFYSWK RVFLTHPATC YRTTCPGPCD 300 SQPCQNGGTC VPEGLDGYQC LCPLAFGGEA NCALKLSLEC RVDLLFLLDS SAGTTLDGFL 360 RAKVFVKRFV RAVLSEDSRA RVGVATYSRE LLVAVPVGEY QDVPDLVWSL DGIPFRGGPT 420

LTGSALRQAA ERGFGSATRT GQDRPRRVW LLTESHSEDE VAGPARHARA RELLLLGVGS 480

EAVRAELEEI TGSPKHVMVY SDPQDLFNQI PELQGKLCSR QRPGCRTQAL DLVFMLDTSA 540

SVGPENFAQM QSFVRSCALQ FEVNPDVTQV GLWYGSQVQ TAFGLDTKPT RAAMLRAISQ 600

APYLGGVGSA GTALLHIYDK VMTVQRGARP GVPKAVWLT GGRGAEDAAV PAQKLRNNGI 660

SVLWGVGPV LSEGLRRLAG PRDSLIHVAA YADLRYHQDV LIEWLCGEAK QPVNLCKPSP 720 CMNEGSCVLQ NGSYRCKCRD GWEGPHCENR FLRRP

Seq ID NO: 88 DNA sequence 0 Nucleic Acid Accession ft: NM_019894

Coding sequence: 1..1314

1 11 21 31 41 51

I I I I I I

ATGTTACAGG ATCCTGACAG TGATCAACCT CTGAACAGCC TCGATGTCAA ACCCCTGCGC 60

15 AAACCCCGTA TCCCCATGGA GACCTTCAGA AAGGTGGGGA TCCCCATCAT CATAGCACTA 120

CTGAGCCTGG CGAGTATCAT CATTGTGGTT GTCCTCATCA AGGTGATTCT GGATAAATAC 180

TACTTCCTCT GCGGGCAGCC TCTCCACTTC ATCCCGAGGA AGCAGCTGTG TGACGGAGAG 240

CTGGACTGTC CCTTGGGGGA GGACGAGGAG CACTGTGTCA AGAGCTTCCC CGAAGGGCCT 300

GCAGTGGCAG TCCGCCTCTC CAAGGACCGA TCCACACTGC AGGTGCTGGA CTCGGCCACA 60 0 GGGAACTGGT TCTCTGCCTG TTTCGACAAC TTCACAGAAG CTCTCGCTGA GACAGCCTGT 420

AGGCAGATGG GCTACAGCAG CAAACCCACT TTCAGAGCTG TGGAGATTGG CCCAGACCAG 480

GATCTGGATG TTGTTGAAAT CACAGAAAAC AGCCAGGAGC TTCGCATGCG GAACTCAAGT 540

GGGCCCTGTC TCTCAGGCTC CCTGGTCTCC CTGCACTGTC TTGCCTGTGG GAAGAGCCTG 600

AAGACCCCCC GTGTGGTGGG TGGGGAGGAG GCCTCTGTGG ATTCTTGGCC TTGGCAGGTC 660 5 AGCATCCAGT ACGACAAACA GCACGTCTGT GGAGGGAGCA TCCTGGACCC CCACTGGGTC 720

CTCACGGCAG CCCACTGCTT CAGGAAACAT

TCAACTGGAA GGTGCGGGCA 780

GGCTCAGACA AACTGGGCAG CTTCCCATCC CTGGCTGTGG CCAAGATCAT CATCATTGAA 840

TTCAACCCCA TGTACCCCAA AGACAATGAC ATCGCCCTCA TGAAGCTGCA GTTCCCACTC 900

ACTTTCTCAG GCACAGTCAG GCCCATCTGT CTGCCCTTCT TTGATGAGGA GCTCACTCCA 960 0 GCCACCCCAC TCTGGATCAT TGGATGGGGC TTTACGAAGC AGAATGGAGG GAAGATGTCT 1020

GACATACTGC TGCAGGCGTC AGTCCAGGTC ATTGACAGCA CACGGTGCAA TGCAGACGAT 1080

GCGTACCAGG GGGAAGTCAC CGAGAAGATG ATGTGTGCAG GCATCCCGGA AGGGGGTGTG 1140

GACACCTGCC AGGGTGACAG TGGTGGGCCC CTGATGTACC AATCTGACCA GTGGCATGTG 1200

GTGGGCATCG TTAGCTGGGG CTATGGCTGC GGGGGCCCGA GCACCCCAGG AGTATACACC 1260 5 AAGGTCTCAG CCTATCTCAA CTGGATCTAC AATGTCTGGA AGGCTGAGCT GTAA

Seq ID NO: 89 Protein sequence:

Protein Accession ft: NP_063947.1

1 11 21 31 41 51 0 I I I I I I

MLQDPDSDQP LNSLDVKPLR KPRIPMETFR KVGIPIIIAL LSLASIIIW VLIKVILDKY 60

YFLCGQPLHF IPRKQLCDGE LDCPLGEDEE HCVKSFPEGP AVAVRLSKDR STLQVLDSAT 120

GNWFSACFDN FTEALAETAC RQMGYSSKPT FRAVEIGPDQ DLDWEITEN SQELRMRNSS 180

GPCLSGSLVS LHCLACGKSL KTPRWGGEE ASVDSWPWQV SIQYDKQHVC GGSILDPHWV 240 5 LTAAHCFRKH TDVFNWKVRA GSDKLGSFPS LAVAKIIIIE FNPMYPKDND IALMKLQFPL 300

TFSGTVRPIC LPFFDEELTP ATPLWIIGWG FTKQNGGKMS DILLQASVQV IDSTRCNADD 360

AYQGEVTEKM MCAGIPEGGV DTCQGDSGGP LMYQSDQWHV VGIVSWGYGC GGPSTPGVYT 420 KVSAYLNWIY NVWKAEL 0 Seq ID NO: 90 DNA sequence

Nucleic Acid Accession ft: NM_002776.1

Coding sequence: 82..912

1 11 21 31 41 51

I I I I I I 5 ACCAGCGGCA GACCACAGGC AGGGCAGAGG CACGTCTGGG TCCCCTCCCT CCTTCCTATC 60

GGCGACTCCC AGATCCTGGC CATGAGAGCT CCGCACCTCC ACCTCTCCGC CGCCTCTGGC 120

GCCCGGGCTC TGGCGAAGCT GCTGCCGCTG CTGATGGCGC AACTCTGGGC CGCAGAGGCG 180

GCGCTGCTCC CCCAAAACGA CACGCGCTTG GACCCCGAAG CCTATGGCGC CCCGTGCGCG 240

CGCGGCTCGC AGCCCTGGCA GGTCTCGCTC TTCAACGGCC TCTCGTTCCA CTGCGCGGGT 300 0 GTCCTGGTGG ACCAGAGTTG GGTGCTGACG GCCGCGCACT GCGGAAACAA GCCACTGTGG 360

GCTCGAGTAG GGGATGATCA CCTGCTGCTT CTTCAGGGCG AGCAGCTCCG CCGGACGACT 420

CGCTCTGTTG TCCATCCCAA GTACCACCAG GGCTCAGGCC CCATCCTGCC AAGGCGAACG 480

GATGAGCACG ATCTCATGTT GCTAAAGCTG GCCAGGCCCG TAGTGCCGGG GCCCCGCGTC 540

CGGGCCCTGC AGCTTCCCTA CCGCTGTGCT CAGCCCGGAG ACCAGTGCCA GGTTGCTGGC 600 5 TGGGGCACCA CGGCCGCCCG GAGAGTGAAG TACAACAAGG GCCTGACCTG CTCCAGCATC 660

ACTATCCTGA GCCCTAAAGA GTGTGAGGTC TTCTACCCTG GCGTGGTCAC CAACAACATG 720

ATATGTGCTG GACTGGACCG GGGCCAGGAC CCTTGCCAGA GTGACTCTGG AGGCCCCCTG 780

GTCTGTGACG AGACCCTCCA AGGCATCCTC TCGTGGGGTG TTTACCCCTG TGGCTCTGCC 840

CAGCATCCAG CTGTCTACAC CCAGATCTGC AAATACATGT CCTGGATCAA TAAAGTCATA 900

70 CGCTCCAACT GATCCAGATG CTACGCTCCA GCTGATCCAG ATGTTATGCT CCTGCTGATC 960

CAGATGCCCA GAGGCTCCAT CGTCCATCCT CTTCCTCCCC AGTCGGCTGA ACTCTCCCCT 1020

TGTCTGCACT GTTCAAACCT CTGCCGCCCT CCACACCTCT AAACATCTCC CCTCTCACCT 1080

CATTCCCCCA CCTATCCCCA TTCTCTGCCT GTACTGAAGC TGAAATGCAG GAAGTGGTGG 1140

CAAAGGTTTA TTCCAGAGAA GCCAGGAAGC CGGTCATCAC CCAGCCTCTG AGAGCAGTTA 1200

75 CTGGGGTCAC CCAACCTGAC TTCCTCTGCC ACTCCCCGCT GTGTGACTTT GGGCAAGCCA 1260

AGTGCCCTCT CTGAACCTCA GTTTCCTCAT CTGCAAAATG GGAACAATGA CGTGCCTACC 1320

TCTTAGACAT GTTGTGAGGA GACTATGATA TAACATGTGT ATGTAAATCT TCATGTGATT 1380

GTCATGTAAG GCTTAACACA GTGGGTGGTG AGTTCTGACT AAAGGTTACC TGTTGTCGTG 1440 AAAAAAAAAA AAAA

80

Seq ID NO: 91 Protein sequence

Protein Accession ft: NP_002767.l

1 11 21 31 41 51 _β - I I I I I I

OJ MRAPHLHLSA ASGARALAKL LPLLMAQLWA AEAALLPQND TRLDPEAYGA PCARGSQPWQ VSLFNGLSFH CAGVLVDQSW VLTAAHCGNK PLWARVGDDH LLLLQGEQLR RTTRSWHPK 120

YHQGSGPILP RRTDEHDLML LKLARPWPG PRVRALQLPY RCAQPGDQCQ VAGWGTTAAR 180

RVKYNKGLTC SSITILSPKE CEVFYPGWT NNMICAGLDR GQDPCQSDSG GPLVCDETLQ 240 GILSWGVYPC GSAQHPAVYT QICKYMSKIN KVIRSN

Seq ID NO: 92 DNA sequence Nucleic Acid Accession ft: NM_032044.1 Coding sequence: 182-658 , . 1 11 21 31 41 51

10 i i i i i i

AAGATATAAA AGCTCCAGAA ACGTTGACTG GGACCACTGG AGACACTGAA GAAGGCAGGG 60

GCCCTTAGAG TCTTGGTTGC CAAACAGATT TGCAGATCAA GGAGAACCCA GGAGTTTCAA 120

AGAAGCGCTA GTAAGGTCTC TGAGATCCTT GCACTAGCTA CATCCTCAGG GTAGGAGGAA 180

GATGGCTTCC AGAAGCATGC GGCTGCTCCT ATTGCTGAGC TGCCTGGCCA AAACAGGAGT 240

15 CCTGGGTGAT ATCATCATGA GACCCAGCTG TGCTCCTGGA TGGTTTTACC ACAAGTCCAA 300

TTGCTATGGT TACTTCAGGA AGCTGAGGAA CTGGTCTGAT GCCGAGCTCG AGTGTCAGTC 360

TTACGGAAAC GGAGCCCACC TGGCATCTAT CCTGAGTTTA AAGGAAGCCA GCACCATAGC 420

AGAGTACATA AGTGGCTATC AGAGAAGCCA GCCGATATGG ATTGGCCTGC ACGACCCACA 480

GAAGAGGCAG CAGTGGCAGT GGATTGATGG GGCCATGTAT CTGTACAGAT CCTGGTCTGG 540

20 CAAGTCCATG GGTGGGAACA AGCACTGTGC TGAGATGAGC TCCAATAACA ACTTTTTAAC 600

TTGGAGCAGC AACGAATGCA ACAAGCGCCA ACACTTCCTG TGCAAGTACC GACCATAGAG 660

CAAGAATCAA GATTCTGCTA ACTCCTGCAC AGCCCCGTCC TCTTCCTTTC TGCTAGCCTG 720

GCTAAATCTG CTCATTATTT CAGAGGGGAA ACCTAGCAAA CTAAGAGTGA TAAGGGCCCT 780

ACTACACTGG CTTTTTTAGG CTTAGAGACA GAAACTTTAG CATTGGCCCA GTAGTGGCTT 840

25 CTAGCTCTAA ATGTTTGCCC CGCCATCCCT TTCCACAGTA TCCTTCTTCC CTCCTCCCCT 900

GTCTCTGGCT GTCTCGAGCA GTCTAGAAGA GTGCATCTCC AGCCTATGAA ACAGCTGGGT 960

CTTTGGCCAT AAGAAGTAAA GATTTGAAGA CAGAAGGAAG AAACTCAGGA GTAAGCTTCT 1020

AGACCCCTTC AGCTTCTACA CCCTTCTGCC CTCTCTCCAT TGCCTGCACC CCACCCCAGC 1080

CACTCAACTC CTGCTTGTTT TTCCTTTGGC CATAGGAAGG TTTACCAGTA GAATCCTTGC 1140

30 TAGGTTGATG TGGGCCATAC ATTCCTTTAA TAAACCATTG TGTACATAAG AAAAAAAAAA

Seq ID NO: 93 Protein sequence Protein Accession #: NP_114433.1 „_ 1 11 21 31 41 51

35 i i i i i i

MASRSMRLLL LLSCLAKTGV LGDIIMRPSC APGWFYHKSN CYGYFRKLRN WSDAELECQS 60

YGNGAHLASI LSLKEASTIA EYISGYQRSQ PIWIGLHDPQ KRQQWQWIDG AMYLYRSWSG 120 KSMGGNKHCA EMSSNNNFLT WSSNECNKRQ HFLCKYRP

40

Seq ID NO: 94 DNA sequence Nucleic Acid Accession ft: XM_051860 Coding sequence: 1..4086 . _ 1 11 21 31 41 51

45 i i i i i i

GAGCTAGCGC TCAAGCAGAG CCCAGCGCGG TGCTATCGGA CAGAGCCTGG CGAGCGCAAG 60

CGGCGCGGGG AGCCAGCGGG GCTGAGCGCG GCCAGGGTCT GAACCCAGAT TTCCCAGACT 120

AGCTACCACT CCGCTTGCCC ACGCCCCGGG AGCTCGCGGC GCCTGGCGGT CAGCGACCAG 180

ACGTCCGGGG CCGCTGCGCT CCTGGCCCGC GAGGCGTGAC ACTGTCTCGG CTACAGACCC 240

50 AGAGGGAGCA CACTGCCAGG ATGGGAGCTG CTGGGAGGCA GGACTTCCTC TTCAAGGCCA 300

TGCTGACCAT CAGCTGGCTC ACTCTGACCT GCTTCCCTGG GGCCACATCC ACAGTGGCTG 360

CTGGGTGCCC TGACCAGAGC CCTGAGTTGC AACCCTGGAA CCCTGGCCAT GACCAAGACC 420

ACCATGTGCA TATCGGCCAG GGCAAGACAC TGCTGCTCAC CTCTTCTGCC ACGGTCTATT 480

CCATCCACAT CTCAGAGGGA GGCAAGCTGG TCATTAAAGA CCACGACGAG CCGATTGTTT 540

55 TGCGAACCCG GCACATCCTG ATTGACAACG GAGGAGAGCT GCATGCTGGG AGTGCCCTCT 600

GCCCTTTCCA GGGCAATTTC ACCATCATTT TGTATGGAAG GGCTGATGAA GGTATTCAGC 660

CGGATCCTTA CTATGGTCTG AAGTACATTG GGGTTGGTAA AGGAGGCGCT CTTGAGTTGC 720

ATGGACAGAA AAAGCTCTCC TGGACATTTC TGAACAAGAC CCTTCACCCA GGTGGCATGG 780

CAGAAGGAGG CTATTTTTTT GAAAGGAGCT GGGGCCACCG TGGAGTTATT GTTCATGTCA 840

60 TCGACCCCAA ATCAGGCACA GTCATCCATT CTGACCGGTT TGACACCTAT AGATCCAAGA 900

AAGAGAGTGA ACGTCTGGTC CAGTATTTGA ACGCGGTGCC CGATGGCAGG ATCCTTTCTG 960

TTGCAGTGAA TGATGAAGGT TCTCGAAATC TGGATGACAT GGCCAGGAAG GCGATGACCA 1020

AATTGGGAAG CAAACACTTC CTGCACCTTG GATTTAGACA CCCTTGGAGT TTTCTAACTG 1080

TGAAAGGAAA TCCATCATCT TCAGTGGAAG ACCATATTGA ATATCATGGA CATCGAGGCT 1140

65 CTGCTGCTGC CCGGGTATTC AAATTGTTCC AGACAGAGCA TGGCGAATAT TTCAATGTTT 1200

CTTTGTCCAG TGAGTGGGTT CAAGACGTGG AGTGGACGGA GTGGTTCGAT CATGATAAAG 1260

TATCTCAGAC TAAAGGTGGG GAGAAAATTT CAGACCTCTG GAAAGCTCAC CCAGGAAAAA 1320

TATGCAATCG TCCCATTGAT ATACAGGCCA CTACAATGGA TGGAGTTAAC CTCAGCACCG 1380

AGGTTGTCTA CAAAAAAGGC CAGGATTATA GGTTTGCTTG CTACGACCGG GGCAGAGCCT 1440

70 GCCGGAGCTA CCGTGTACGG TTCCTCTGTG GGAAGCCTGT GAGGCCCAAA CTCACAGTCA 1500

CCATTGACAC CAATGTGAAC AGCACCATTC TGAACTTGGA GGATAATGTA CAGTCATGGA 1S60

AACCTGGAGA TACCCTGGTC ATTGCCAGTA CTGATTACTC CATGTACCAG GCAGAAGAGT 1620

TCCAGGTGCT TCCCTGCAGA TCCTGCGCCC CCAACCAGGT CAAAGTGGCA GGGAAACCAA 1680

TGTACCTGCA CATCGGGGAG GAGATAGACG GCGTGGACAT GCGGGCGGAG GTTGGGCTTC 1740

75 TGAGCCGGAA CATCATAGTG ATGGGGGAGA TGGAGGACAA ATGCTACCCC TACAGAAACC 1800

ACATCTGCAA TTTCTTTGAC TTCGATACCT TTGGGGGCCA CATCAAGTTT GCTCTGGGAT 1860

TTAAGGCAGC ACACTTGGAG GGCACGGAGC TGAAGCATAT GGGACAGCAG CTGGTGGGTC 1920

AGTACCCGAT TCACTTCCAC CTGGCCGGTG ATGTAGACGA AAGGGGAGGT TATGACCCAC 1980

CCACATACAT CAGGGACCTC TCCATCCATC ATACATTCTC TCGCTGCGTC ACAGTCCATG 2040

80 GCTCCAATGG CTTGTTGATC AAGGACGTTG TGGGCTATAA CTCTTTGGGC CACTGCTTCT 2100

TCACGGAAGA TGGGCCGGAG GAACGCAACA CTTTTGACCA CTGTCTTGGC CTCCTTGTCA 2160

AGTCTGGAAC CCTCCTCCCC TCGGACCGTG ACAGCAAGAT GTGCAAGATG ATCACAGAGG 2220

ACTCCTACCC GGGGTACATC CCCAAGCCCA GGCAAGACTG CAATGCTGTG TCCACCTTCT 2280

GGATGGCCAA TCCCAACAAC AACCTCATCA ACTGTGCCGC TGCAGGATCT GAGGAAACTG 2340

85 GATTTTGGTT TATTTTTCAC CACGTACCAA CGGGCCCCTC CGTGGGAATG TACTCCCCAG 2400 GTTATTCAGA GCACATTCCA CTGGGAAAAT TCTATAACAA CCGAGCACAT TCCAACTACC 2460

GGGCTGGCAT GATCATAGAC AACGGAGTCA AAACCACCGA GGCCTCTGCC AAGGACAAGC 2520

GGCCGTTCCT CTCAATCATC TCTGCCAGAT ACAGCCCTCA CCAGGACGCC GACCCGCTGA 2580

AGCCCCGGGA GCCGGCCATC ATCAGACACT TCATTGCCTA CAAGAACCAG GACCACGGGG 2640 CCTGGCTGCG CGGCGGGGAT GTGTGGCTGG ACAGCTGCCG GTTTGCTGAC AATGGCATTG 2700

GCCTGACCCT GGCCAGTGGT GGAACCTTCC CGTATGACGA CGGCTCCAAG CAAGAGATAA 2760

AGAACAGCTT GTTTGTTGGC GAGAGTGGCA ACGTGGGGAC GGAAATGATG GACAATAGGA 2820

TCTGGGGCCC TGGCGGCTTG GACCATAGCG GAAGGACCCT CCCTATAGGC CAGAATTTTC 2880

CAATTAGAGG AATTCAGTTA TATGATGGCC CCATCAACAT CCAAAACTGC ACTTTCCGAA 2940 AGTTTGTGGC CCTGGAGGGC CGGCACACCA GCGCCCTGGC CTTCCGCCTG AATAATGCCT 000

GGCAGAGCTG CCCCCATAAC AACGTGACCG GCATTGCCTT TGAGGACGTT CCGATTACTT 3060

CCAGAGTGTT CTTCGGAGAG CCTGGGCCCT GGTTCAACCA GCTGGACATG GATGGGGATA 3120

AGACATCTGT GTTCCATGAC GTCGACGGCT CCGTGTCCGA GTACCCTGGC TCCTACCTCA 3180

CGAAGAATGA CAACTGGCTG GTCCGGCACC CAGACTGCAT CAATGTTCCC GACTGGAGAG 3240 GGGCCATTTG CAGTGGGTGC TATGCACAGA TGTACATTCA AGCCTACAAG ACCAGTAACC 3300

TGCGAATGAA GATCATCAAG AATGACTTCC CCAGCCACCC TCTTTACCTG GAGGGGGCGC 3360

TCACCAGGAG CACCCATTAC CAGCAATACC AACCGGTTGT CACCCTGCAG AAGGGCTACA 3420

CCATCCACTG GGACCAGACG GCCCCCGCCG AACTCGCCAT CTGGCTCATC AACTTCAACA 3480

AGGGCGACTG GATCCGAGTG GGGCTCTGCT ACCCGCGAGG CACCACATTC TCCATCCTCT 3S40 CGGATGTTCA CAATCGCCTG CTGAAGCAAA CGTCCAAGAC GGGCGTCTTC GTGAGGACCT 3600

TGCAGATGGA CAAAGTGGAG CAGAGCTACC CTGGCAGGAG CCACTACTAC TGGGACGAGG 3660

ACTCAGGGCT GTTGTTCCTG AAGCTGAAAG CTCAGAACGA GAGAGAGAAG TTTGCTTTCT 3720

GCTCCATGAA AGGCTGTGAG AGGATAAAGA TTAAAGCTCT GATTCCAAAG AACGCAGGCG 3780

TCAGTGACTG CACAGCCACA GCTTACCCCA AGTTCACCGA GAGGGCTGTC GTAGACGTGC 3840 CGATGCCCAA GAAGCTCTTT GGTTCTCAGC TGAAAACAAA GGACCATTTC TTGGAGGTGA 3900

AGATGGAGAG TTCCAAGCAG CACTTCTTCC ACCTCTGGAA CGACTTCGCT TACATTGAAG 3960

TGGATGGGAA GAAGTACCCC AGTTCGGAGG ATGGCATCCA GGTGGTGGTG ATTGACGGGA 4020

ACCAAGGGCG CGTGGTGAGC CACACGAGCT TCAGGAACTC CATTCTGCAA GGCATACCAT 4080

GGCAGCTTTT CAACTATGTG GCGACCATCC CTGACAATTC CATAGTGCTT ATGGCATCAA 4140 AGGGAAGATA CGTCTCCAGA GGCCCATGGA CCAGAGTGCT GGAAAAGCTT GGGGCAGACA 4200

GGGGTCTCAA GTTGAAAGAG CAAATGGCAT TCGTTGGCTT CAAAGGCAGC TTCCGGCCCA 4260

TCTGGGTGAC ACTGGACACT GAGGATCACA AAGCCAAAAT CTTCCAAGTT GTGCCCATCC 4320

CTGTGGTGAA GAAGAAGAAG TTGTGAGGAC AGCTGCCGCC CGGTGCCACC TCGTGGTAGA 4380

CTATGACGGT GACTCTTGGC AGCAGACCAG TGGGGGATGG CTGGGTCCCC CAGCCCCTGC 4440 CAGCAGCTGC CTGGGAAGGC CGTGTTTCAG CCCTGATGGG CCAAGGGAAG GCTATCAGAG 4500

ACCCTGGTGC TGCCACCTGC CCCTACTCAA GTGTCTACCT GGAGCCCCTG GGGCGGTGCT 4560

GGCCAATGCT GGAAACATTC ACTTTCCTGC AGCCTCTTGG GTGCTTCTCT CCTATCTGTG 4620

CCTCTTCAGT GGGGGTTTGG GGACCATATC AGGAGACCTG GGTTGTGCTG ACAGCAAAGA 4680

TCCACTTTGG CAGGAGCCCT GACCCAGCTA GGAGGTAGTC TGGAGGGCTG GTCATTCACA 4740 GATCCCCATG GTCTTCAGCA GACAAGTGAG GGTGGTAAAT GTAGGAGAAA GAGCCTTGGC 4800

CTTAAGGAAA TCTTTACTCC TGTAAGCAAG AGCCAACCTC ACAGGATTAG GAGCTGGGGT 4860

AGAACTGGCT ATCCTTGGGG AAGAGGCAAG CCCTGCCTCT GGCCGTGTCC ACCTTTCAGG 4920

AGAGTTTGAG TGGCAGGTTT GGACTTGGAC TAGATGACTC TCAAAGGCCC TTTTAGTTCT 4980

GAGATTCCAG AAATCTGCTG CATTTCACAT GGTACCTGGA ACCCAACAGT TCATGGATAT 5040 CCACTGATAT CCATGATGCT GGGTGCCCCA GCGCACACGG GATGGAGAGG TGAGAACTAA 5100

TGCCTAGCTT GAGGGGTCTG CAGTCCAGTA GGGCAGGCAG TCAGGTCCAT GTGCACTGCA 5160

ATGCCAGGTG GAGAAATCAC AGAGAGGTAA AATGGAGGCC AGTGCCATTT CAGAGGGGAG 5220

GCTCAGGAAG GCTTCTTGCT TACAGGAATG AAGGCTGGGG GCATTTTGCT GGGGGGAGAT 5280

GAGGCAGCCT CTGGAATGGC TCAGGGATTC AGCCCTCCCT GCCGCTGCCT GCTGAAGCTG 5340 GTGACTACGG GGTCGCCCTT TGCTCACGTC TCTCTGGCCC ACTCATGATG GAGAAGTGTG 5400

GTCAGAGGGG AGCAATGGGC TTTGCTGCTT ATGAGCACAG AGGAATTCAG TCCCCAGGCA 5460

GCCCTGCCTC TGACTCCAAG AGGGTGAAGT CCACAGAAGT GAGCTCCTGC CTTAGGGCCT 5520

CATTTGCTCT TCATCCAGGG AACTGAGCAC AGGGGGCCTC CAGGAGACCC TAGATGTGCT 5580

CGTACTCCCT CGGCCTGGGA TTTCAGAGCT GGAAATATAG AAAATATCTA GCCCAAAGCC 5640 TTCATTTTAA CAGATGGGGA AAGTGAGCCC CCAAGATGGG AAAGAACCAC ACAGCTAAGG 5700

GAGGGCCTGG GGAGCGCCAC CCTAGCCCTT GCTGCCACAC CACATTGCCT CAACAACCGG 5760

CCCCAGAGTG CCCAGGCACT CCTGAGGTAG CTTCTGGAAA TGGGGACAAG TCCCCTCGAA 5820

GGAAAGGAAA TGACTAGAGT AGAATGACAG CTAGCAGATC TCTTCCCTCC TGCTCCCAGC 5880

GCACACAAAC CCGCCCTCCC CTTGGTGTTG GCGGTCCCTG TGGCCTTCAC TTTGTTCACT 5940 ACCTGTCAGC CCAGCCTGGG TGCACAGTAG CTGCAACTCC CCATTGGTGC TACCTGGCTC 6000

TCCTGTCTCT GCAGCTCTAC AGGTGAGGCC CAGCAGAGGG AGTAGGGCTC GCCATGTTTC 6060

TGGTGAGCCA ATTTGGCTGA TCTTGGGTGT CTGAACAGCT ATTGGGTCCA CCCCAGTCCC 6120

TTTCAGCTGC TGCTTAATGC CCTGCTCTCT CCCTGGCCCA CCTTATAGAG AGCCCAAAGA 6180

GCTCCTGTAA GAGGGAGAAC TCTATCTGTG GTTTATAATC TTGCACGAGG CACCAGAGTC 6240 TCCCTGGGTC TTGTGATGAA CTACATTTAT CCCCTTTCCT GCCCCAACCA CAAACTCTTT 6300

CCTTCAAAGA GGGCCTGCCT GGCTCCCTCC ACCCAACTGC ACCCATGAGA CTCGGTCCAA 6360

GAGTCCATTC CCCAGGTGGG AGCCAACTGT CAGGGAGGTC TTTCCCACCA AACATCTTTC 6420

AGCTGCTGGG AGGTGACCAT AGGGCTCTGC TTTTAAAGAT ATGGCTGCTT CAAAGGCCAG 6480

AGTCACAGGA AGGACTTCTT CCAGGGAGAT TAGTGGTGAT GGAGAGGAGA GTTAAAATGA 6540 CCTCATGTCC TTCTTGTCCA CGGTTTTGTT GAGTTTTCAC TCTTCTAATG CAAGGGTCTC 6600

ACACTGTGAA CCACTTAGGA TGTGATCACT TTCAGGTGGC CAGGAATGTT GAATGTCTTT 6660

GGCTCAGTTC ATTTAAAAAA GATATCTATT TGAAAGTTCT CAGAGTTGTA CATATGTTTC 6720

ACAGTACAGG ATCTGTACAT AAAAGTTTCT TTCCTAAACC ATTCACCAAG AGCCAATATC 6780

TAGGCATTTT CTTGGTAGCA CAAATTTTCT TATTGCTTAG AAAATTGTCC TCCTTGTTAT 6840 TTCTGTTTGT AAGACTTAAG TGAGTTAGGT CTTTAAGGAA AGCAACGCTC CTCTGAAATG 6900

CTTGTCTTTT TTCTGTTGCC GAAATAGCTG GTCCTTTTTC GGGAGTTAGA TGTATAGAGT 6960

GTTTGTATGT AAACATTTCT TGTAGGCATC ACCATGAACA AAGATATATT TTCTATTTAT 7020 TTATTATATG TGCACTTCAA GAAGTCACTG TCAGAGAAAT AAAGAATTGT CTTAAATGTC Seq ID NO: 95 Protein sequence

Protein Accession ft: XP_0S1860.2

1 11 21 31 41 51

I I I I I I

MGAAGRQDFL FKAMLTISWL TLTCFPGATS TVAAGCPDQS PELQPWNPGH DQDHHVHIGQ 60 GKTLLLTSSA TVYSIHISEG GKLVIKDHDE PIVLRTRHIL IDNGGELHAG SALCPFQGNF 120 TIILYGRADE GIQPDPYYGL KYIGVGKGGA LELHGQKKLS WTFLNKTLHP GGMAEGGYFF 180 ERSWGHRGVI VHVIDPKSGT VIHSDRFDTY RSKKESERLV QYLNAVPDGR ILSVAVNDEG 240 SRNLDDMARK AMTKLGSKHF LHLGFRHPWS FLTVKGNPSS SVEDHIEYHG HRGSAAARVF 300 KLFQTEHGEY FNVSLSSEWV QDVEWTEWFD HDKVSQTKGG EKISDLWKAH PGKICNRPID 360 IQATTMDGVN LSTEWYKKG QDYRFACYDR GRACRSYRVR FLCGKPVRPK LTVTIDTNVN 420 STI NLEDNV QSWKPGDTLV IASTDYSMYQ AEEFQVLPCR SCAPNQVKVA GKPMYLHIGE 480 EIDGVDMRAE VGLLSRNIIV MGEMEDKCYP YRNHICNFFD FDTFGGHIKF ALGFKAAHLE 540 GTELKHMGQQ LVGQYPIHFH LAGDVDERGG YDPPTYIRDL SIHHTFSRCV TVHGSNGLLI 600 KDWGYNSLG HCFFTEDGPE ERNTFDHCLG LLVKSGTLLP SDRDSKMCKM ITEDSYPGYI 660 PKPRQDCNAV STFWMANPNN NLINCAAAGS EETGFWFIFH HVPTGPSVGM YSPGYSEHIP 720 LGKFYNNRAH SNYRAGMIID NGVKTTEASA KDKRPFLSII SARYSPHQDA DPLKPREPAI 780 IRHFIAYKNQ DHGAWLRGGD VWLDSCRFAD NGIGLTLASG GTFPYDDGSK QEIKNSLFVG 840 ESGNVGTEMM DNRIWGPGGL DHSGRTLPIG QNFPIRGIQL YDGPINIQNC TFRKFVALEG 900 RHTSALAFRL NNAWQSCPHN NVTGIAFEDV PITSRVFFGE PGPWFNQLDM DGDKTSVFHD 960 VDGSVSEYPG SYLTKNDNWL VRHPDCINVP DWRGAICSGC YAQMYIQAYK TSNLRMKIIK 1020 NDFPSHPLYL EGALTRSTHY QQYQPWTLQ KGYTIHWDQT APAELAIWLI NFNKGDWIRV 1080 GLCYPRGTTF SILSDVHNRL LKQTSKTGVF VRTLQMDKVE QSYPGRSHYY WDEDSGLLFL 1140 KLKAQNEREK FAFCSMKGCE RIKIKALIPK NAGVSDCTAT AYPKFTERAV VDVPMPKKLF 1200 GSQLKTKDHF LEVKMESSKQ HFFHLWNDFA YIEVDGKKYP SSEDGIQVW IDGNQGRWS 1260 HTSFRNSILQ GIPWQLFNYV ATIPDNSIVL MASKGRYVSR GPWTRVLEKL GADRGLKLKE 1320 QMAFVGFKGS FRPIWVTLDT EDHKAKIFQV VPIPWKKKK L

60

120

180 CGGGGGAGCT GGGTGCTCCA GTGAACCACC CAGGGAATGA CGAGGTGGCG AGTGAGGATG 240 AAGCCACAGT AAAGCGGCTT CGTCGGGAGG AGACGCACGT CTGTGAGAAA TGCTGTGCGG 300 AGTTCTTCAG CATCTCTGAG TTCCTGGAAC ATAAGAAAAA TTGCACTAAA AATCCACCTG 360 TCCTCATCAT GAATGACAGC GAGGGGCCTG TGCCTTCAGA AGACTTCTCC GGAGCTGTAC 420 TGAGCCACCA GCCCACCAGT CCCGGCAGTA AGGACTGTCA CAGGGAGAAT GGCGGCAGCT 480 CAGAGGACAT GAAGGAGAAG CCGGATGCGG AGTCTGTGGT GTACCTAAAG ACAGAGACAG 540 CCCTGCCACC CACCCCCCAG GACATAAGCT ATTTAGCCAA AGGCAAAGTG GCCAACACTA 600 ATGTGACCTT GCAGGCACTA CGGGGCACCA AGGTGGCGGT GAATCAGCGG AGCGCGGATG 660 CACTCCCTGC CCCCGTGCCT GGTGCCAACA GCATCCCGTG GGTCCTCGAG CAGATCTTGT 720 GTCTGCAGCA GCAGCAGCTA CAGCAGATCC AGCTCACCGA GCAGATCCGC ATCCAGGTGA 780 ACATGTGGGC CTCCCACGCC CTCCACTCAA GCGGGGCAGG GGCCGACACT CTGAAGACCT 840 TGGGCAGCCA CATGTCTCAG CAGGTTTCTG CAGCTGTGGC TTTGCTCAGC CAGAAAGCTG 900 GAAGCCAAGG TCTGTCTCTG GATGCCTTGA AACAAGCCAA GCTACCTCAC GCCAACATCC 960 CTTCTGCCAC CAGCTCCCTG TCCCCAGGGC TGGCACCCTT CACTCTGAAG CCGGATGGGA 1020 CCCGGGTGCT CCCGAACGTC ATGTCCCGCC TCCCGAGCGC TTTGCTTCCT CAGGCCCCGG 1080 GCTCGGTGCT CTTCCAGAGC CCTTTCTCCA CTGTGGCGCT AGACACATCC AAGAAAGGGA 1140 AGGGGAAGCC ACCGAACATC TCCGCGGTGG ATGTCAAACC CAAAGACGAG GCGGCCCTCT 1200 ACAAGCACAA GTGTAAGTAC TGTAGCAAGG TTTTTGGGAC TGATAGCTCC TTGCAGATCC 1260 ACCTCCGCTC CCACACTGGA GAGAGACCCT TCGTGTGCTC TGTCTGTGGT CATCGCTTCA 1320 CCACCAAGGG CAACCTCAAG GTGCACTTTC ACCGACATCC CCAGGTGAAG GCAAACCCCC 1380 AGCTGTTTGC CGAGTTCCAG GACAAAGTGG CGGCCGGCAA TGGCATCCCC TATGCACTCT 1440 CTGTACCTGA CCCCATAGAT GAACCGAGTC TTTCTTTAGA CAGCAAACCT GTCCTTGTAA 1500 CCACCTCTGT AGGGCTACCT CAGAATCTTT CTTCGGGGAC TAATCCCAAG GACCTCACGG 1560 GTGGCTCCTT GCCCGGTGAC CTGCAGCCTG GGCCTTCTCC AGAAAGTGAG GGTGGACCCA 1620 CACTCCCTGG GGTGGGACCA AACTATAATT CCCCAAGGGC TGGTGGCTTC CAAGGGAGTG 1680 GGACCCCTGA GCCAGGGTCA GAGACCCTGA AATTGCAGCA GTTGGTGGAG AACATTGACA 1740 AGGCCACCAC TGATCCCAAC GAATGTCTCA TTTGCCACCG AGTCTTAAGC TGTCAGAGCT 1800 CCCTCAAGAT GCATTATCGC ACCCACACCG GGGAGAGACC GTTCCAGTGT AAGATCTGTG 1860 GCCGAGCCTT TTCTACCAAA GGTAACCTGA AGACACACCT TGGGGTTCAC CGAACCAACA 1920 CATCCATTAA GACGCAGCAT TCGTGCCCCA TCTGCCAGAA GAAGTTCACT AATGCCGTGA 1980 TGCTGCAGCA ACATATTCGG ATGCACATGG GCGGTCAGAT TCCCAACACG CCCCTGCCAG 2040 AGAATCCCTG TGACTTTACG GGTTCTGAGC CAATGACCGT GGGTGAGAAC GGCAGCACCG 2100 GCGCTATCTG CCATGATGAT GTCATCGAAA GCATCGATGT AGAGGAAGTC AGCTCCCAGG 2160 AGGCTCCCAG CAGCTCCTCC AAGGTCCCCA CGCCTCTTCC CAGCATCCAC TCGGCATCAC 2220 CCACGCTAGG GTTTGCCATG ATGGCTTCCT TAGATGCCCC AGGGAAAGTG GGTCCTGCCC 2280 CTTTTAACCT GCAGCGCCAG GGCAGCAGAG AAAACGGTTC CGTGGAGAGC GATGGCTTGA 2340 CCAACGACTC ATCCTCGCTG ATGGGAGACC AGGAGTATCA GAGCCGAAGC CCAGATATCC 2400 TGGAAACCAC ATCCTTCCAG GCACTCTCCC CGGCCAATAG TCAAGCCGAA AGCATCAAGT 2460 CAAAGTCTCC CGATGCTGGG AGCAAAGCAG AGAGCTCCGA GAACAGCCGC ACTGAGATGG 2520 AAGGTCGGAG CAGTCTCCCT TCCACGTTTA TCCGAGCCCC GCCGACCTAT GTCAAGGTTG 2580 AAGTTCCTGG CACATTTGTG GGACCCTCGA CATTGTCCCC AGGGATGACC CCTTTGTTAG 2640 CAGCCCAGCC ACGCCGACAG GCCAAGCAAC ATGGCTGCAC ACGGTGTGGG AAGAACTTCT 2700 CGTCTGCTAG CGCTCTTCAG ATCCACGAGC GGACTCACAC TGGAGAGAAG CCTTTTGTGT 2760 GCAACATTTG TGGGCGAGCT TTTACCACCA AAGGCAACTT AAAGGTTCAC TACATGACAC 2820 ACGGGGCGAA CAATAACTCA GCCCGCCGTG GAAGGAAGTT GGCCATCGAβ AACACCATGG 2880 CTCTGTTAGG TACGGACGGA AAAAGAGTCT CAGAAATCTT TCCCAAGGAA ATCCTGGCCC 2940 CTTCAGTGAA TGTGGACCCT GTTGTGTGGA ACCAGTACAC CAGCATGCTC AATGGCGGTC 3000 TGGCCGTGAA GACCAATGAG ATCTCTGTGA TCCAGAGTGG GGGGGTTCCT ACCCTCCCGG 3060 TTTCCTTGGG GGCCACCTCC GTTGTGAATA ACGCCACTGT CTCCAAGATG GATGGCTCCC 3120 AGTCGGGTAT CAGTGCAGAT GTGGAAAAAC CAAGTGCTAC TGACGGCGTT CCCAAACACC 3180 AGTTTCCTCA CTTCCTGGAA GAAAACAAGA TTGCGGTCAG CTAAGGGAGA ACTTGCGTGG 3240 AAGGAGCAAT GCAGACACAG TGAAATCTCT AGAATCTGCT TTGTTTTGTA AGAACTCATC 3300 TCCTCCTGTT TTCTTTTTCT TACTGATATG CAAATGATGT TTACTACGTT GGTTGTGACC 3360 ACAACCTCAG GCAAGTGCTA CAATCACGAT TGTTGCTATG CTGCTTTGCA AAAAGTTG Seq ID NO: 97 Protein sequence: Protein Accession ft: NP_065169.1 1 11 21 31 41 51

I I I I I I

MSRRKQAKPQ HINSEEDQGE QQPQQQTPEF ADAAPAAPAA GELGAPVNHP GNDEVASEDE 60

ATVKRLRREE THVCEKCCAE FFSISEFLEH KKNCTKNPPV LIMNDSEGPV PSEDFSGAVL 120

SHQPTSPGSK DCHRENGGSS EDMKEKPDAE SWYLKTETA LPPTPQDISY LAKGKVANTN 180

VTLQALRGTK VAVNQRSADA LPAPVPGANS IPWVLEQILC LQQQQLQQIQ LTEQIRIQVN 240

MWASHALHSS GAGADTLKTL GSHMSQQVSA AVALLSQKAG SQGLSLDALK QAKLPHANIP 300

SATSSLSPGL APFTLKPDGT RVLPNVMSRL PSALLPQAPG SVLFQSPFST VALDTSKKGK 360

GKPPNISAVD VKPKDEAALY KHKCKYCSKV FGTDSSLQIH LRSHTGERPF VCSVCGHRFT 420

TKGNLKVHFH RHPQVKANPQ LFAEFQDKVA AGNGIPYALS VPDPIDEPSL SLDSKPVLVT 480

TSVGLPQNLS SGTNPKDLTG GSLPGDLQPG PSPESEGGPT LPGVGPNYNS PRAGGFQGSG 540

TPEPGSETLK LQQLVENIDK ATTDPNECLI CHRVLSCQSS LKMHYRTHTG ERPFQCKICG 600

RAFSTKGNLK THLGVHRTNT SIKTQHSCPI CQKKFTNAVM LQQHIRMHMG GQIPNTPLPE 660

NPCDFTGSEP MTVGENGSTG AICHDDVIES IDVEEVSSQE APSSSSKVPT PLPSIHSASP 720

TLGFAMMASL DAPGKVGPAP FNLQRQGSRE NGSVESDGLT NDSSSLMGDQ EYQSRSPDIL 780

ETTSFQALSP ANSQAESIKS KSPDAGSKAE SSENSRTEME GRSSLPSTFI RAPPTYVKVE 840

VPGTFVGPST LSPGMTPLLA AQPRRQAKQH GCTRCGKNFS SASALQIHER THTGEKPFVC 900

NICGRAFTTK GNLKVHYMTH GANNNSARRG RKLAIENTMA LLGTDGKRVS EIFPKEILAP 960

SVNVDPWWN QYTSMLNGGL AVKTNEISVI QSGGVPTLPV SLGATSWNN ATVSKMDGSQ 1020 SGISADVEKP ΞATDGVPKHQ FPHFLEENKI AVS

Seq ID NO: 98 DNA sequence Nucleic Acid Accession ft: NM 000612.2

Coding sequence: 553..1095

1 11 21 31 41 SI

I I I I I I

TTCTCCCGCA ACCTTCCCTT CGCTCCCTCC CGTCCCCCCC AGCTCCTAGC CTCCGACTCC 60

CTCCCCCCCT CACGCCCGCC CTCTCGCCTT CGCCGAACCA AAGTGGATTA ATTACACGCT 120

TTCTGTTTCT CTCCGTGCTG TTCTCTCCCG CTGTGCGCCT GCCCGCCTCT CGCTGTCCTC 180

TCTCCCCCTC GCCCTCTCTT CGGCCCCCCC CTTTCACGTT CACTCTGTCT CTCCCACTAT 240

CTCTGCCCCC CTCTATCCTT GATACAACAG CTGACCTCAT TTCCCGATAC CTTTTCCCCC 300

CCGAAAAGTA CAACATCTGG CCCGCCCCAG CCCGAAGACA GCCCGTCCTC CCTGGACAAT 360

CAGACGAATT CTCCCCCCCC CCCCAAAAAA AAAAGCCATC CCCCCGCTCT GCCCCGTCGC 420

ACATTCGGCC CCCGCGACTC GGCCAGAGCG GCGCTGGCAG AGGAGTGTCC GGCAGGAGGG 480

CCAACGCCCG CTGTTCGGTT TGCGACACGC AGCAGGGAGG TGGGCGGCAG CGTCGCCGGC 540

TTCCAGACAC CAATGGGAAT CCCAATGGGG AAGTCGATGC TGGTGCTTCT CACCTTCTTG 600

GCCTTCGCCT CGTGCTGCAT TGCTGCTTAC CGCCCCAGTG AGACCCTGTG CGGCGGGGAG 660

CTGGTGGACA CCCTCCAGTT CGTCTGTGGG GACCGCGGCT TCTACTTCAG CAGGCCCGCA 720

AGCCGTGTGA GCCGTCGCAG CCGTGGCATC GTTGAGGAGT GCTGTTTCCG CAGCTGTGAC 780

CTGGCCCTCC TGGAGACGTA CTGTGCTACC CCCGCCAAGT CCGAGAGGGA CGTGTCGACC 840

CCTCCGACCG TGCTTCCGGA CAACTTCCCC AGATACCCCG TGGGCAAGTT CTTCCAATAT 900

GACACCTGGA AGCAGTCCAC CCAGCGCCTG CGCAGGGGCC TGCCTGCCCT CCTGCGTGCC 960

CGCCGGGGTC ACGTGCTCGC CAAGGAGCTC GAGGCGTTCA GGGAGGCCAA ACGTCACCGT 1020

CCCCTGATTG CTCTACCCAC CCAAGACCCC GCCCACGGGG GCGCCCCCCC AGAGATGGCC 1080

AGCAATCGGA AGTGAGCAAA ACTGCCGCAA GTCTGCAGCC CGGCGCCACC ATCCTGCAGC 1140

CTCCTCCTGA CCACGGACGT TTCCATCAGG TTCCATCCCG AAAATCTCTC GGTTCCACGT 1200

CCCCCTGGGG CTTCTCCTGA CCCAGTCCCC GTGCCCCGCC TCCCCGAAAC AGGCTACTCT 1260

CCTCGGCCCC CTCCATCGGG CTGAGGAAGC ACAGCAGCAT CTTCAAACAT GTACAAAATC 1320 GATTGGCTTT AAACACCCTT CACATACCCT CCCCCC

Seq ID NO: 99 Protein sequence

Protein Accession ft: NP_000603.1

1 11 21 31 41 51

I I I I I I

MGIPMGKSML VLLTFLAFAS CCIAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPASRVS 60

RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV LPDNFPRYPV GKFFQYDTWK 120 QSTQRLRRGL PALLRARRGH VLAKELEAFR EAKRHRPLIA LPTQDPAHGG APPEMASNRK

Seq ID NO: 100 DNA sequence

NUcleic Acid Accession ft: NM_004217.1

Coding sequence: 58..1092 1 11 21 31 41 51 i i I i i i

GGCCGGGAGA GTAGCAGTGC CTTGGACCCC AGCTCTCCTC CCCCTTTCTC TCTAAGGATG 60

GCCCAGAAGG AGAACTCCTA CCCCTGGCCC TACGGCCGAC AGACGGCTCC ATCTGGCCTG 120

AGCACCCTGC CCCAGCGAGT CCTCCGGAAA GAGCCTGTCA CCCCATCTGC ACTTGTCCTC 180

ATGAGCCGCT CCAATGTCCA GCCCACAGCT GCCCCTGGCC AGAAGGTGAT GGAGAATAGC 240

AGTGGGACAC CCGACATCTT AACGCGGCAC TTCACAATTG ATGACTTTGA GATTGGGCGT 300

CCTCTGGGCA AAGGCAAGTT TGGAAACGTG TACTTGGCTC GGGAGAAGAA AAGCCATTTC 360

ATCGTGGCGC TCAAGGTCCT CTTCAAGTCC CAGATAGAGA AGGAGGGCGT GGAGCATCAG 420

CTGCGCAGAG AGATCGAAAT CCAGGCCCAC CTGCACCATC CCAACATCCT GCGTCTCTAC 480

AACTATTTTT ATGACCGGAG GAGGATCTAC TTGATTCTAG AGTATGCCCC CCGCGGGGAG 540

CTCTACAAGG AGCTGCAGAA GAGCTGCACA TTTGACGAGC AGCGAACAGC CACGATCATG 600

GAGGAGTTGG CAGATGCTCT AATGTACTGC CATGGGAAGA AGGTGATTCA CAGAGACATA 660

AAGCCAGAAA ATCTGCTCTT AGGGCTCAAG GGAGAGCTGA AGATTGCTGA CTTCGGCTGG 720

TCTGTGCATG CGCCCTCCCT GAGGAGGAAG ACAATGTGTG GCACCCTGGA CTACCTGCCC 780

CCAGAGATGA TTGAGGGGCG CATGCACAAT GAGAAGGTGG ATCTGTGGTG CATTGGAGTG 840

CTTTGCTATG AGCTGCTGGT GGGGAACCCA CCCTTTGAGA GTGCATCACA CAACGAGACC 900

TATCGCCGCA TCGTCAAGGT GGACCTAAAG TTCCCCGCTT CTGTGCCCAC GGGAGCCCAG 960

GACCTCATCT CCAAACTGCT CAGGCATAAC CCCTCGGAAC GGCTGCCCCT GGCCCAGGTC 1020

TCAGCCCACC CTTGGGTCCG GGCCAACTCT CGGAGGGTGC TGCCTCCCTC TGCCCTTCAA 1080

TCTGTCGCCT GATGGTCCCT GTCATTCACT CGGGTGCGTG TGTTTGTATG TCTGTGTATG 1140

TATAGGGGAA AGAAGGGATC CCTAACTGTT CCCTTATCTG TTTTCTACCT CCTCCTTTGT 1200 TTAATAAAGG CTGAAGCTTT TTGT

Seq ID NO: 101 Protein sequence

Protein Accession ft: NP_004208

1 11 21 31 41 51

I I I I I I

MAQKENSYPW PYGRQTAPSG LSTLPQRVLR KEPVTPSALV LMSRSNVQPT AAPGQKVMEN 60

SSGTPDILTR HFTIDDFEIG RPLGKGKFGN VYLAREKKSH FIVALKVLFK SQIEKEGVEH 120

QLRREIEIQA HLHHPNILRL YNYFYDRRRI YLILEYAPRG ELYKELQKSC TFDEQRTATI 180

MEELADALMY CHGKKVIHRD IKPENLLLGL KGELKIADFG WSVHAPSLRR KTMCGTLDYL 240

PPEMIEGRMH NEKVDLWCIG VLCYELLVGN PPFESASHNE TYRRIVKVDL KFPASVPTGA 300 QDLISKLLRH NPSERLPLAQ VSAHPWVRAN SRRVLPPSAL QSVA

Seq ID NO: 102 DNA sequence Nucleic Acid Accession ft: AK025790

Coding sequence: 56..1642

1 11 21 31 41 51

I I I I I I

AGTATCCCAG GAGGAGCAAG TGGCACGTCT TCGGACCTAG GCTGCCCCTG CCGTCATGTC 60

GCAAGGGATC CTTTCTCCGC CAGCGGGCTT GCTGTCCGAT GACGATGTCG TAGTTTCTCC 120

CATGTTTGAG TCCACAGCTG CAGATTTGGG GTCTGTGGTA CGCAAGAACC TGCTATCAGA 180

CTGCTCTGTC GTCTCTACCT CCCTAGAGGA CAAGCAGCAG GTTCCATCTG AGGACAGTAT 240

GGAGAAGGTG AAAGTATACT TGAGGGTTAG GCCCTTGTTA CCTTCAGAGT TGGAACGACA 300

GGAAGATCAG GGTTGTGTCC GTATTGAGAA TGTGGAGACC CTTGTTCTAC AAGCACCCAA 360

GGACTCTTTT GCCCTGAAGA GCAATGAACG GGGAATTGGC CAAGCCACAC ACAGGTTCAC 420

CTTTTCCCAG ATCTTTGGGC CAGAAGTGGG ACAGGCATCC TTCTTCAACC TAACTGTGAA 480

GGAGATGGTA AAGGATGTAC TCAAAGGGCA GAACTGGCTC ATCTATACAT ATGGAGTCAC 540

TAACTCAGGG AAAACCCACA CGATTCAAGG TACCATCAAG GATGGAGGGA TTCTCCCCCG 600

GTCCCTGGCG CTGATCTTCA ATAGCCTCCA AGGCCAACTT CATCCAACAC CTGATCTGAA 660

GCCCTTGCTC TCCAATGAGG TAATCTGGCT AGACAGCAAG CAGATCCGAC AGGAGGAAAT 720

GAAGAAGCTG TCCCTGCTAA ATGGAGGCCT CCAAGAGGAG GAGCTGTCCA CTTCCTTGAA 780

GAGGAGTGTC TACATCGAAA GTCGGATAGG TACCAGCACC AGCTTCGACA GTGGCATTGC 840

TGGGCTCTCT TCTATCAGTC AGTGTACCAG CAGTAGCCAG CTGGATGAAA CAAGTCATCG 900

ATGGGCACAG CCAGACACTG CCCCACTACC TGTCCCGGCA AACATTCGCT TCTCCATCTG 960

GATCTCATTC TTTGAGATCT ACAACGAACT GCTTTATGAC CTATTAGAAC CGCCTAGCCA 1020

ACAGCGCAAG AGGCAGACTT TGCGGCTATG CGAGGATCAA AATGGCAATC CCTATGTGAA 1080

AGATCTCAAC TGGATTCATG TGCAAGATGC TGAGGAGGCC TGGAAGCTCC TAAAAGTGGG 1140

TCGTAAGAAC CAGAGCTTTG CCAGCACCCA CCTCAACCAG AACTCCAGCC GCAGTCACAG 1200

CATCTTCTCA ATCAGGATCC TACACCTTCA GGGGGAAGGA GATATAGTCC CCAAGATCAG 1260

CGAGCTGTCA CTCTGTGATC TGGCTGGCTC AGAGCGCTGC AAAGATCAGA AGAGTGGTGA 1320

ACGGTTGAAG GAAGCAGGAA ACATTAACAC CTCTCTACAC ACCCTGGGCC GCTGTATTGC 1380

TGCCCTTCGT CAAAACCAGC AGAACCGGTC AAAGCAGAAC CTGGTTCCCT TCCGTGACAG 1440

CAAGTTGACT CGAGTGTTCC AAGGTTTCTT CACAGGCCGA GGCCGTTCCT GCATGATTGT 1500

CAATGTGAAT CCCTGTGCAT CTACCTATGA TGAAACTCTT CATGTGGCCA AGTTCTCAGC 1560

CATTGCTAGC CAGGTGACTT GTGCATGCCC CACCTATGCA ACTGGGATTC CCATCCCTGC 1620

ACTCGTTCAT CAAGGAACAT AGTCTTCAGG TATCCCCCAG CTTAGAGAAA GGGGCTAAGG 1680

CAGACACAGG CCTTGATGAT GATATTGAAA ATGAAGCTGA CATCTCCATG TATGGCAAAG 1740

AGGAGCTCCT ACAAGTTGTG GAAGCCATGA AGACACTGCT TTTGAAGGAA CGACAGGAAA 1800

AGCTACAGCT GGAGATGCAT CTCCGAGATG AAATTTGCAA TGAGATGGTA GAACAGATGC 1860

AACAGCGGGA ACAGTGGTGC AGTGAACATT TGGACACCCA AAAGGAACTA TTGGAGGAAA 1920

TGTATGAAGA AAAACTAAAT ATCCTCAAGG AGTCACTGAC AAGTTTTTAC CAAGAAGAGA 1980

TTCAGGAGCG GGATGAAAAG ATTGAAGAGC TAGAAGCTCT CTTGCAGGAA GCCAGACAAC 2040

AGTCAGTGGC CCATCAGCAA TCAGGGTCTG AATTGGCCCT ACGGCGGTCA CAAAGGTTGG 2100

CAGCTTCTGC CTCCACCCAG CAGCTTCAGG AGGTTAAAGC TAAATTACAG CAGTGCAAAG 2160

CAGAGCTAAA CTCTACCACT GAAGAGTTGC ATAAGTATCA GAAAATGTTA GAACCACCAC 2220

CCTCAGCCAA GCCCTTCACC ATTGATGTGG ACAAGAAGTT AGAAGAGGGC CAGAAGAATA 2280

TAAGGCTGTT GCGGACAGAG CTTCAGAAAC TTGGTGAGTC TCTCCAATCA GCAGAGAGAG 2340

CTTGTTGCCA CAGCACTGGG GCAGGAAAAC TTCGTCAAGC CTTGACCACT TGTGATGACA 2400

TCTTAATCAA ACAGGACCAG ACTCTGGCTG AACTGCAGAA CAACATGGTG CTAGTGAAAC 2460

TGGACCTTCG GAAGAAGGCA GCATGTATTG CTGAGCAGTA TCATACTGTG TTGAAACTCC 2520

AAGGCCAGGT TTCTGCCAAA AAGCGCCTTG GTACCAACCA GGAAAATCAG CAACCAAACC 2580

AACAACCACC AGGGAAGAAA CCATTCCTTC GAAATTTACT TCCCCGAACA CCAACCTGCC 2640

AAAGCTCAAC AGACTGCAGC CCTTATGCCC GGATCCTACG CTCACGGCGT TCCCCTTTAC 2700

TCAAATCTGG GCCTTTTGGC AAAAAGTACT AAGGCTGTGG GGAAAGAGAA GAGCAGTCAT 2760

GGCCCTGAGG TGGGTCAGCT ACTCTCCTGA AGAAATAGGT CTCTTTTATG CTTTACCATA 2820

TATCAGGAAT TATATCCAGG ATGCAATACT CAGACACTAG CTTTTTTCTC ACTTTTGTAT 2880

TATAACCACC TATGTAATCT CATGTTGTTG TTTTTTTTTA TTTACTTATA TGATTTCTAT 2940

GCACACAAAA ACAGTTATAT TAAAGATATT ATTGTTCACA TTTTTTATTG AATTCCAAAT 3000 GTAGCAAAAT CATTAAAACA AATTATAAAA GGGACAGAAA AA

Seq ID NO: 103 Protein sequence

Protein Accession ft: NP_005724.1

1 11 21 31 41 51

I I I I I I

MSQGILSPPA GLLSDDDWV SPMFESTAAD LGSWRKNLL SDCSWSTSL EDKQQVPSED 60

SMEKVKVYLR VRPLLPSELE RQEDQGCVRI ENVETLVLQA PKDSFALKSN ERGIGQATHR 120

FTFSQIFGPE VGQASFFNLT VKEMVKDVLK GQNWLIYTYG VTNSGKTHTI QGTIKDGGIL 180

PRSLALIFNS LQGQLHPTPD LKPLLSNEVI WLDSKQIRQE EMKKLSLLNG GLQEEELSTS 240

LKRSVYIESR IGTSTSFDSG IAGLSSISQC TSSSQLDETS HRWAQPDTAP LPVPANIRFS 300

IWISFFEIYN ELLYDLLEPP SQQRKRQTLR LCEDQNGNPY VKDLNWIHVQ DAEEAWKLLK 360

VGRKNQSFAS THLNQNSSRS HSIFSIRILH LQGEGDIVPK ISELSLCDLA GSERCKDQKS 420

GERLKEAGNI NTSLHTLGRC IAALRQNQQN RSKQNLVPFR DSKLTRVFQG FFTGRGRSCM 480 IVNVNPCAST YDETLHVAKF SAIASQVTCA CPTYATGIPI PALVHQGT

Seq ID NO: 104 DNA sequence Nucleic Acid Accession ft: NM_006952.1

Coding sequence: 11..793

1 11 21 31 41 51

I I I I I I

AATCCCGACA ATGGCGAAAG ACAACTCAAC TGTTCGTTGC TTCCAGGGCC TGCTGATTTT 60

TGGAAATGTG ATTATTGGTT GTTGCGGCAT TGCCCTGACT GCGGAGTGCA TCTTCTTTGT 120

ATCTGACCAA CACAGCCTCT ACCCACTGCT TGAAGCCACC GACAACGATG ACATCTATGG 180

GGCTGCCTGG ATCGGCATAT TTGTGGGCAT CTGCCTCTTC TGCCTGTCTG TTCTAGGCAT 240

TGTAGGCATC ATGAAGTCCA GCAGGAAAAT TCTTCTGGCG TATTTCATTC TGATGTTTAT 300

10 AGTATATGCC TTTGAAGTGG CATCTTGTAT CACAGCAGCA ACACAACGAG ACTTTTTCAC 360

ACCCAACCTC TTCCTGAAGC AGATGCTAGA GAGGTACCAA AACAACAGCC CTCCAAACAA 420

TGATGACCAG TGGAAAAACA ATGGAGTCAC CAAAACCTGG GACAGGCTCA TGCTCCAGGA 480

CAATTGCTGT GGCGTAAATG GTCCATCAGA CTGGCAAAAA TACACATCTG CCTTCCGGAC S40

TGAGAATAAT GATGCTGACT ATCCCTGGCC TCGTCAATGC TGTGTTATGA ACAATCTTAA 600

15 AGAACCTCTC AACCTGGAGG CTTGTAAACT AGGCGTGCCT GGTTTTTATC ACAATCAGGG 660

CTGCTATGAA CTGATCTCTG GTCCAATGAA CCGACACGCC TGGGGGGTTG CCTGGTTTGG 720

ATTTGCCATT CTCTGCTGGA CTTTTTGGGT TCTCCTGGGT ACCATGTTCT ACTGGAGCAG 780 AATTGAATAT TAAGAA

20 Seq ID NO: 105 Protein sequence

Protein Accession ft: NP_008883.1

1 11 21 31 41 51

I I I I I I

MAKDNSTVRC FQGLLIFGNV IIGCCGIALT AECIFFVSDQ HSLYPLLEAT DNDDIYGAAW 60

25 IGIFVGICLF CLSVLGIVGI MKSSRKILLA YFILMFIVYA FEVASCITAA TQRDFFTPNL 120

FLKQMLERYQ NNSPPNNDDQ WKNNGVTKTW DRLMLQDNCC GVNGPSDWQK YTSAFRTENN 180

DADYPWPRQC CVMNNLKEPL NLEACKLGVP GFYHNQGCYE LISGPMNRHA WGVAWFGFAI 240 LCWTFWVLLG TMFYWSRIEY

30 Seq ID NO: 106 DNA sequence

Nucleic Acid Accession ft: NM_002740.1

Coding sequence: 178..1968

1 11 21 31 41 51

, - I I I I I I

_>J CCGCGGTTCC GGCTGCTCCG GCGAGGCGAC CCTTGGGTCG GCGCTGCGGG CGAGGTGGGC 60

AGGTAGGTGG GCGGACGGCC GCGGTTCTCC GGCAAGCGCA GGCGGCGGAG TCCCCCACGG 120

CGCCCGAAGC GCCCCCCGCA CCCCCGGCCT CCAGCGTTGA GGCGGGGGAG TGAGGAGATG 180

CCGACCCAGA GGGACAGCAG CACCATGTCC CACACGGTCG CAGGCGGCGG CAGCGGGGAC 240

CATTCCCACC AGGTCCGGGT GAAAGCCTAC TACCGCGGGG ATATCATGAT AACACATTTT 300

40 GAACCTTCCA TCTCCTTTGA GGGCCTTTGC AATGAGGTTC GAGACATGTG TTCTTTTGAC 360

AACGAACAGC TCTTCACCAT GAAATGGATA GATGAGGAAG GAGACCCGTG TACAGTATCA 420

TCTCAGTTGG AGTTAGAAGA AGCCTTTAGA CTTTATGAGC TAAACAAGGA TTCTGAACTC 480

TTGATTCATG TGTTCCCTTG TGTACCAGAA CGTCCTGGGA TGCCTTGTCC AGGAGAAGAT S40

AAATCCATCT ACCGTAGAGG TGCACGCCGC TGGAGAAAGC TTTATTGTGC CAATGGCCAC 600

45 ACTTTCCAAG CCAAGCGTTT CAACAGGCGT GCTCACTGTG CCATCTGCAC AGACCGAATA 660

TGGGGACTTG GACGCCAAGG ATATAAGTGC ATCAACTGCA AACTCTTGGT TCATAAGAAG 720

TGCCATAAAC TCGTCACAAT TGAATGTGGG CGGCATTCTT TGCCACAGGA ACCAGTGATG 780

CCCATGGATC AGTCATCCAT GCATTCTGAC CATGCACAGA CAGTAATTCC ATATAATCCT 840

TCAAGTCATG AGAGTTTGGA TCAAGTTGGT GAAGAAAAAG AGGCAATGAA CACCAGGGAA 900

50 AGTGGCAAAG CTTCATCCAG TCTAGGTCTT CAGGATTTTG ATTTGCTCCG GGTAATAGGA 960

AGAGGAAGTT ATGCCAAAGT ACTGTTGGTT CGATTAAAAA AAACAGATCG TATTTATGCA 1020

ATGAAAGTTG TGAAAAAAGA GCTTGTTAAT GATGATGAGG ATATTGATTG GGTACAGACA 1080

GAGAAGCATG TGTTTGAGCA GGCATCCAAT CATCCTTTCC TTGTTGGGCT GCATTCTTGC 1140

TTTCAGACAG AAAGCAGATT GTTCTTTGTT ATAGAGTATG TAAATGGAGG AGACCTAATG 1200

55 TTTCATATGC AGCGACAAAG AAAACTTCCT GAAGAACATG CCAGATTTTA CTCTGCAGAA 1260

ATCAGTCTAG CATTAAATTA TCTTCATGAG CGAGGGATAA TTTATAGAGA TTTGAAACTG 1320

GACAATGTAT TACTGGACTC TGAAGGCCAC ATTAAACTCA CTGACTACGG CATGTGTAAG 1380

GAAGGATTAC GGCCAGGAGA TACAACCAGC ACTTTCTGTG GTACTCCTAA TTACATTGCT 1440

CCTGAAATTT TAAGAGGAGA AGATTATGGT TTCAGTGTTG ACTGGTGGGC TCTTGGAGTG 1500

60 CTCATGTTTG AGATGATGGC AGGAAGGTCT CCATTTGATA TTGTTGGGAG CTCCGATAAC 1560

CCTGACCAGA ACACAGAGGA TTATCTCTTC CAAGTTATTT TGGAAAAACA AATTCGCATA 1620

CCACGTTCTC TGTCTGTAAA AGCTGCAAGT GTTCTGAAGA GTTTTCTTAA TAAGGACCCT 1680

AAGGAACGAT TGGGTTGTCA TCCTCAAACA GGATTTGCTG ATATTCAGGG ACACCCGTTC 1740

TTCCGAAATG TTGATTGGGA TATGATGGAG CAAAAACAGG TGGTACCTCC CTTTAAACCA 1800

65 AATATTTCTG GGGAATTTGG TTTGGACAAC TTTGATTCTC AGTTTACTAA TGAACCTGTC 1860

CAGCTCACTC CAGATGACGA TGACATTGTG AGGAAGATTG ATCAGTCTGA ATTTGAAGGT 1920

TTTGAGTATA TCAATCCTCT TTTGATGTCT GCAGAAGAAT GTGTCTGATC CTCATTTTTC 1980

AACCATGTAT TCTACTCATG TTGCCATTTA ATGCATGGAT AAACTTGCTG CAAGCCTGGA 2040

TACAATTAAC CATTTTATAT TTGCCACCTA CAAAAAAACA CCCAATATCT TCTCTTGTAG 2100

70 ACTATATGAA TCAATTATTA CATCTGTTTT ACTATGAAAA AAAAATTAAT ACTACTAGCT 2160

TCCAGACAAT CATGTCAAAA TTTAGTTGAA CTGGTTTTTC AGTTTTTAAA AGGCCTACAG 2220 ATGAGTAATG AAGTTACCTT TTTTGTTTAA AAAAAAAAAA G

Seq ID NO: 107 Protein sequence 75 Protein Accession ft: NP_002731.1

1 11 21 31 41 51

I I 1 I I I

MSHTVAGGGS GDHSHQVRVK AYYRGDIMIT HFEPSISFEG LCNEVRDMCS FDNEQLFTMK 60

WIDEEGDPCT VSSQLELEEA FRLYELNKDS ELLIHVFPCV PERPGMPCPG EDKSIYRRGA 120

80 RRWRKLYCAN GHTFQAKRFN RRAHCAICTD RIWGLGRQGY KCINCKLLVH KKCHKLVTIE 180

CGRHSLPQEP VMPMDQSSMH SDHAQTVIPY NPSSHESLDQ VGEEKEAMNT RESGKASSSL 240

GLQDFDLLRV IGRGSYAKVL LVRLKKTDRI YAMKWKKEL VNDDEDIDWV QTEKHVFEQA 300

SNHPFLVGLH SCFQTESRLF FVIEYVNGGD LMFHMQRQRK LPEEHARFYS AEISLALNYL 360

HERGIIYRDL KLDNVLLDSE GHIKLTDYGM CKEGLRPGDT TSTFCGTPNY IAPEILRGED 420

85 YGFSVDWWAL GVLMFEMMAG RSPEDIVGSS DNPDQNTEDY LFQVILEKQI RIPRSLSVKA 480 ASVLKSFLNK DPKERLGCHP QTGFADIQGH PFFRNVDWDM MEQKQWPPF KPNISGEFGL 540 DNFDSQFTNE PVQLTPDDDD IVRKIDQSEF EGFEYINPLL MSAEECV

Seq ID NO: 108 DNA sequence

Nucleic Acid Accession ft: NM_000349.1

Coding sequence: 127..984

1 11 21 31 41 51

I I I I I I

GGGACTCAGA GGCGAAGCTT GAGGGGCTCA GGAAGGACGA AGAACCACCC TTGAGAGAAG 60

AGGCAGCAGC AGCGGCGGCA GCAGCAGCGG CAGCGACCCC ACCACTGCCA CATTTGCCAG 120

GAAACAATGC TGCTAGCGAC ATTCAAGCTG TGCGCTGGGA^• GCTCCTACAG ACACATGCGC 180

AACATGAAGG GGCTGAGGCA ACAGGCTGTG ATGGCCATCA GCCAGGAGCT GAACCGGAGG 240

GCCCTGGGGG GCCCCACCCC TAGCACGTGG ATTAACCAGG TTCGGCGGCG GAGCTCTCTA 300

CTCGGTTCTC GGCTGGAAGA GACTCTCTAC AGTGACCAGG AGCTGGCCTA TCTCCAGCAG 360

GGGGAGGAGG CCATGCAGAA GGCCTTGGGC ATCCTTAGCA ACCAAGAGGG CTGGAAGAAG 420

GAGAGTCAGC AGGACAATGG GGACAAAGTG ATGAGTAAAG TGGTCCCAGA TGTGGGCAAG 480

GTGTTCCGGC TGGAGGTCGT GGTGGACCAG CCCATGGAGA GGCTCTATGA AGAGCTCGTG 540

GAGCGCATGG AAGCAATGGG GGAGTGGAAC CCCAATGTCA AGGAGATCAA GGTCCTGCAG 600

AAGATCGGAA AAGATACATT CATTACTCAC GAGCTGGCTG CCGAGGCAGC AGGAAACCTG 660

GTGGGGCCCC GTGACTTTGT GAGCGTGCGC TGTGCCAAGC GCCGAGGCTC CACCTGTGTG 720

CTGGCTGGCA TGGACACAGA CTTCGGGAAC ATGCCTGAGC AGAAGGGTGT CATCAGGGCG 780

GAGCACGGTC CCACTTGCAT GGTGCTTCAC CCGTTGGCTG GAAGTCCCTC TAAGACCAAA 840

CTTACGTGGC TACTCAGCAT CGACCTCAAG GGGTGGCTGC CCAAGAGCAT CATCAACCAG 900

GTCCTGTCCC AGACCCAGGT GGATTTTGCC AACCACCTGC GCAAGCGCCT GGAGTCCCAC 960

CCTGCCTCTG AAGCCAGGTG TTGAAGACCA GCCTGCTGTT CCCAACTGTG CCCAGCTGCA 1020

CTGGTACACA CGCTCATCAG GAGAATCCCT AeTGGAAGCC TGCAAGTCTA AGATCTCCAT 1080

CTGGTGACAG TGGGATGGGT GGGGTTCGTG TTTAGAGTAT GACACTAGGA TTCAGATTGG 1140

TGAAGTTTTT AGTACCAAGA AAACAGGGAT GAGGCTCTTG GATTAAAAGG TAACTTCATT 1200

CACTGATTAG CTATGACATG AGGGTTCAGG CCCCTAAAAT AATTGTAAAA CTTTTTTTCT 1260

GGGCCCTTAT GTACCCACCT AAAACCATCT TTAAAATGCT AGTGGCTGAT ATGGGTGTGG 1320

GGGATGCTAA CCACAGGGCC TGAGAAGTCT TGCTTTATGG GCTCAAGAAT GCCATGCGCT 1380

GGCAGTACAT GTGCACAAAG CAGAATCTCA GAGGGTCTCC TGCAGCCCTC TGCTCCTCCC 1440

GGCCGCTGCA CAGCAACACC ACAGAACAAG CAGCACCCCA CAGTGGGTGC CTTCCAGAAA 1500

TATAGTCCAA GCTTTCTCTG TGGAAAAAGA CAAAACTCAT TAGTAGACAT GTTTCCCTAT 1560 TGCTTTCATA GGCACCAGTC AGAATAAAGA ATCATAATTC ACACC

Seq ID NO: 109 Protein sequence

Protein Accession ft: NP_000340.1

1 11 21 31 41 51 i i i i i i

MLLATFKLCA GSSYRHMRNM KGLRQQAVMA ISQELNRRAL GGPTPSTWIN QVRRRSSLLG 60

SRLEETLYSD QELAYLQQGE EAMQKALGIL SNQEGWKKES QQDNGDKVMS KWPDVGKVF 120

RLEVWDQPM ERLYEELVER MEAMGEWNPN VKEIKVLQKI GKDTFITHEL AAEAAGNLVG 180

PRDFVSVRCA KRRGSTCVLA GMDTDFGNMP EQKGVIRAEH GPTCMVLHPL AGSPSKTKLT 240

WLLSIDLKGW LPKSIINQVL SQTQVDFANH LRKRLESHPA SEARC

Seq ID NO: 110 DNA sequence

Nucleic Acid Accession ft: EOS sequence

Coding sequence: 131-682

1 11 21 31 41 51

I I I I I I

GCTGGGAGCC TGGGCCGGGA GCCGGGTGAG GGCGCCGAGA GGCTCGGTGG GCGCGGGCGG 60

CGAGATATGC CACACTTCTG CCTGCTGTTG GCAACCCTCC TGGACTAGGC TGCTCTTGTT 120

AATCACATGG ATGTTATATA AGAGTTCGGA CCGCCCAGCA CACAAGGTCA GCATGCTGCT 180

CCTCTGTCAC GCTCTCGCTA TAGCTGTTGT CCAGATCGTT ATCTTCTCAG AAAGCTGGGC 240

ATTTGCCAAG AACATCAACT TCTATAATGT GAGGCCTCCT CTCGACCCTA CACCATTTCC 300

AAATAGCTTC AAGTGCTTTA CTTGTGAAAA CGCAGGGGAT AATTATAACT GCAATCGATG 360

GGCAGAAGAC AAATGGTGTC CACAAAATAC ACAGTACTGT TTGACAGTTC ATCACTTCAC 420

CAGCCACGGA AGAAGCACAT CCATCACCAA AAAGTGTGCC TCCAGAAGTG AATGTCATTT 480

TGTCGGTTGC CACCACAGCC GAGATTCTGA ACATACGGAG TGTAGGTCTT GCTGTGAAGG 540

AATGATCTGC AATGTAGAAT TACCCACCAA TCACACTAAT GCAGTGTTTG CCGTAATGCA 600

CGCTCAGAGA ACATCTGGCA GCAGTGCCCC CACACTCTAC CTACCAGTGC TTGCCTGGGT 660

CTTTGTGCTT CCATTGCTGT GATGCCACCA TTCCTAGGAG AGGCAGAGAC CAGCCTCTAA 720

AGCACAAGCC AAAAACTGTG TGAACGGTGA ACTTTGGAGT GAAGATCAAT CTTGCACTTG 780

GTGAAGAGTG CACATTGGAC CTCAAGGCGA AAGCCAGTGG TTTGCTTGGA TAAAATGTTC 840

CCGCATGAGG CCACAGGACT GAGGATGGGA ATTTGGCAGG GCCTGAGAAG ATGGTCTGAC 900

TTCCAGGCTT CCTGGTCAAA GAGAGCTACG TTTGGGCAGT TCTGCAGAGA GGATCCTGGC 960

AACTAGTCCC ACCTGACTAG GCCTTTAGCT GAAAGGATTT CTTGACCTCC TTGACTGCCT 1020

CAGAGGCTGC CAGGTCAAAC CCTCTTGTTT ATGTGATTAG CTCAGAGCAT CTCTATGAAA 1080

TCTAACCCTT CCCCTCATGA GAAAGCAGTT TTCCCCACCA ACAGCATAGT CAATGAGAAA 1140

GGCAACTGTA CGAAGAAAAC TTCCAGTGGA ACTAATATGA AATCTATTTG CAAATTATGG 1200 GGGGAAATAA AGCTTTTAAA TTATACAATG T

Seq ID NO: 111 Protein sequence Protein Accession ft: AAM20908.1

1 11 21 31 41 51

I I I I I I

MLYKSSDRPA HKVSMLLLCH ALAIAWQIV IFSESWAFAK NINFYNVRPP LDPTPFPNSF 60

KCFTCENAGD NYNCNRWAED KWCPQNTQYC LTVHHFTSHG RSTSITKKCA SRSECHFVGC 120

HHSRDSEHTE CRSCCEGMIC NVELPTNHTN AVFAVMHAQR TSGSSAPTLY LPVLAWVFVL 180 PLL

Seq ID NO: 112 DNA sequence Nucleic Acid Accession ft: Eos sequence Coding sequence: 228-884 60

120

180

GCCTGCTGTT GGCAACCCTC CTGGACTAGG CTGCTCTTGT TAATCACATG GATGTTGCTG 240

ATTACTCTGA GTGCAAACCT TTTCACTGTT CCAGAGAGGA GCCTGACAAC CACATTCTCC 300

TTCTCAAGGT GTGGTGCTTA CTGCGCAGGC TGACCAGATA TAAGAGTTCG GACCGCCCAG 360

CACACAAGGT CAGCATGCTG CTCCTCTGTC ACGCTCTCGC TATAGCTGTT GTCCAGATCG 420

TTATCTTCTC AGAAAGCTGG GCATTTGCCA AGAACATCAA CTTCTATAAT GTGAGGCCTC 480

CTCTCGACCC TACACCATTT CCAAATAGCT TCAAGTGCTT TACTTGTGAA AACGCAGGGG 540

ATAATTATAA CTGCAATCGA TGGGCAGAAG ACAAATGGTG TCCACAAAAT ACACAGTACT 600

GTTTGACAGT TCATCACTTC ACCAGCCACG GAAGAAGCAC ATCCATCACC AAAAAGTGTG 660

CCTCCAGAAG TGAATGTCAT TTTGTCGGTT GCCACCACAG CCGAGATTCT GAACATACGG 720

AGTGTAGGTC TTGCTGTGAA GGAATGATCT GCAATGTAGA ATTACCCACC AATCACACTA 780

ATGCAGTGTT TGCCGTAATG CACGCTCAGA GAACATCTGG CAGCAGTGCC CCCACACTCT 840

ACCTACCAGT GCTTGCCTGG GTCTTTGTGC TTCCATTGCT GTGATGCCAC CATTCCTAGG 900

AGAGGCAGAG ACCAGCCTCT AAAGCACAAG CCAAAAACTG TGTGAACGGT GAACTTTGGA 960

GTGAAGATCA ATCTTGCACT TGGTGAAGAG TGCACATTGG ACCTCAAGGC GAAAGCCAGT 1020

GGTTTGCTTG GATAAAATGT TCCCGCATGA GGCCACAGGA CTGAGGATGG GAATTTGGCA 1080

GGGCCTGAGA AGATGGTCTG ACTTCCAGGC TTCCTGGTCA AAGAGAGCTA CGTTTGGGCA 1140

GTTCTGCAGA GAGGATCCTG GCAACTAGTC CCACCTGACT AGGCCTTTAG CTGAAAGGAT 1200

TTCTTGACCT CCTTGACTGC CTCAGAGGCT GCCAGGTCAA ACCCTCTTGT TTATGTGATT 1260

AGCTCAGAGC ATCTCTATGA AATCTAACCC TTCCCCTCAT GAGAAAGCAG TTTTCCCCAC 1320

CAACAGCATA GTCAATGAGA AAGGCAACTG TACGAAGAAA ACTTCCAGTG GAACTAATAT 1380

GAAATCTATT TGCAAATTAT GGGGGGAAAT SAAGCTTTTA AATTATAAA

Seq ID NO:, 113 Protein sequence

Protein Accession ft: Eos sequence

1 11 21 31 41 51

I I I I I I

MDVADYSECK PFHCSREEPD NHILLLKVWC LLRRLTRYKS SDRPAHKVSM LLLCHALAIA 60 WQIVIFSES WAFAKNINFY NVRPPLDPTP FPNSFKCFTC ENAGDNYNCN RWAEDKWCPQ 120 NTQYCLTVHH FTSHGRSTSI TKKCASRSEC HFVGCHHSRD SEHTECRSCC EGMICNVELP 180 TNHTNAVFAV MHAQRTSGSS APTLYLPVLA WVFVLPLL

Seq ID NO: 114 DNA sequence

Nucleic Acid Accession ft: EOS sequence

Coding sequence: 402-1025

1 11 21 31

I I I I

ACTTCCTGAG CCGGGCTGGC TGGGTGGGAA CAGGCTCCTT GCCGCCTCCC CAGCGCTGGC 60 CACTACCACA CTGCCGCCCG CCTGGGCCTC CTTTCAACCT CGTGGTGGAG CCCTGCGGTT 120 TCCCAGCGGA GCCGGGCCCG GGGCTGCTCC CTCGCGGGCG AGGCTCACCT GTCCCGGCCC 180 GGCCCCCTCC CGCGCCCCAG GTGGTTCAGG GCAGGGAGGA GCCGCGCCCC GCCCCGCGCG 240 GTAGCAGCCA ACGCCGGCCC CAGGCGGGTG CGCTGGGAGC CTGGGCCGGG AGCCGGGTGA 300 GGGCGCCGAG AGGCTCGGTG GGCGCGGGCG GCGAGATATG CCACACTTCT GCCTGCTGTT 360 GGCAACCCTC CTGGACTAGG CTGCTCTTGT TAATCACATG GATGTTGCTG ATTACTCTGA 420 GTGCAAACCT TTTCACTGTT CCAGAGAGGA GCCTGACAAC CACATTCTCC TTCTCAAGAT 480 ATAAGAGTTC GGACCGCCCA GCACACAAGG TCAGCATGCT GCTCCTCTGT CACGCTCTCG 540 CTATAGCTGT TGTCCAGATC GTTATCTTCT CAGAAAGCTG GGCATTTGCC AAGAACATCA 600 ACTTCTATAA TGTGAGGCCT CCTCTCGACC CTACACCATT TCCAAATAGC TTCAAGTGCT 660 TTACTTGTGA AAACGCAGGG GATAATTATA ACTGCAATCG ATGGGCAGAA GACAAATGGT 720 GTCCACAAAA TACACAGTAC TGTTTGACAG TTCATCACTT CACCAGCCAC GGAAGAAGCA 780 CATCCATCAC CAAAAAGTGT GCCTCCAGAA GTGAATGTCA TTTTGTCGGT TGCCACCACA 840 GCCGAGATTC TGAACATACG GAGTGTAGGT CTTGCTGTGA AGGAATGATC TGCAATGTAG 900 AATTACCCAC CAATCACACT AATGCAGTGT TTGCCGTAAT GCACGCTCAG AGAACATCTG 960 GCAGCAGTGC CCCCACACTC TACCTACCAG TGCTTGCCTG GGTCTTTGTG CTTCCATTGC 1020 TGTGATGCCA CCATTCCTAG GAGAGGCAGA GACCAGCCTC TAAAGCACAA GCCAAAAACT 1080 GTGTGAACGG TGAACTTTGG AGTGAAGATC AATCTTGCAC TTGGTGAAGA GTGCACATTG 1140 GACCTCAAGG CGAAAGCCAG TGGTTTGCTT GGATAAAATG" TTCCCGCATG AGGCCACAGG 1200 ACTGAGGATG GGAATTTGGC AGGGCCTGAG AAGATGGTCT GACTTCCAGG CTTCCTGGTC 1260 AAAGAGAGCT ACGTTTGGGC AGTTCTGCAG AGAGGATCCT GGCAACTAGT CCCACCTGAC 1320 TAGGCCTTTA GCTGAAAGGA TTTCTTGACC TCCTTGACTG CCTCAGAGGC TGCCAGGTCA 1380 AACCCTCTTG TTTATGTGAT TAGCTCAGAG CATCTCTATG AAATCTAACC CTTCCCCTCA 1440 TGAGAAAGCA GTTTTCCCCA CCAACAGCAT AGTCAATGAG AAAGGCAACT GTACGAAGAA 1500 AACTTCCAGT GGAACTAATA TGAAATCTAT TTGCAAATTA TGGGGGGAAA TAAAGCTTTT 1560 AAATTATACA ATGT

Seq ID NO: 115 Protein sequence

Protein Accession ft: EOS sequence

1 11 21 31 41 51

I I I I I I

MLLITLSANL FTVPERSLTT TFSFSRYKSS DRPAHKVSML LLCHALAIAV VQIVIFSESW 60

AFAKNINFYN VRPPLDPTPF PNSFKCFTCE NAGDNYNCNR WAEDKWCPQN TQYCLTVHHF 120

TSHGRSTSIT KKCASRSECH FVGCHHSRDS EHTECRSCCE GMICNVELPT NHTNAVFAVM 180

HAQRTSGSSA PTLYLPVLAW VFVLP

Seq ID NO : 116 DNA sequence Nucleic Acid Accession ft : Eos sequence

Coding sequence : 1-1059 1 11 21 31 41 51

I I I I I I

ATGGTATGGC AGCAAGATTA TGGAACCAGG AGAGAGCACC ATGGCTGCCG TCTGGAATTC 60 TGCCGTGTAT CTGCAGGGTG CCCTTGCCTA AGCCCCTTGA CCTCTTTGGT TATAGTTTCC 120 TCATCTGCTG AGAGAGGTGA GGAAGCTGCA GAAGAAGACT TTGAAACTAG CAGAGGTGGG 180

TTCATGAGGA TGAAGGAAAG AAGCCATGCC CATAACATAA AAGTGCAAGG TGAAGCAGGA 240

GGTGCTGATG AAGAAGCTGC AGCAAGTGAT CCAGAAGATC TAGCTAAGAT CATTGATGAA 300

GATGTGAAAG GCATTGTACA GAAGAAGATG AGAATCACAG TAAACCAAAC AAAGGAAATG 360

CAGAAGAGAT ATTTTCAGCT GAATATTGGA AATGTAAAAT GCCACACGTT GGATGAGATG 420

ATTATCCGAG CTCAGACTTG GGAAATAGTC ATGCTTCTGG ACCAAGTGCC AGGTCCTGGC 480

CCTACACAAC AGGTAGATGG TTGGATATAT TTGGATAATG GAGCTTTCCA AACAGAAGCA 540

AAACACAAAC CCACTGATGT AAAATATAAA GAAACTGAAC CAGTGTGTCT TTTCACCATA 600

GATATAAGAG TTCGGACCGC CCAGCACACA AGAATAAAAC AGAAAGTCTC CATTACTTCT 660

ATGGCTACAC CATTTCCAAA TAGCTTCAAG TGCTTTACTT GTGAAAACGC AGGGGATAAT 720

TATAACTGCA ATCGATGGGC AGAAGACAAA TGGTGTCCAC AAAATACACA GTACTGTTTG 780

ACAGTTCATC ACTTCACCAG CCACGGAAGA AGCACATCCA TCACCAAAAA GTGTGCCTCC 840

AGAAGTGAAT GTCATTTTGT CGGTTGCCAC CACAGCCGAG ATTCTGAACA TACGGAGTGT 900

AGGTCTTGCT GTGAAGGAAT GATCTGCAAT GTAGAATTAC CCACCAATCA CACTAATGCA 960

GTGTTTGCCG TAATGCACGC TCAGAGAACA TCTGGCAGCA GTGCCCCCAC ACTCTACCTA 1020

CCAGTGCTTG CCTGGGTCTT TGTGCTTCCA TTGCTGTGAT GCCACCATTC CTAGGAGAGG 1080

CAGAGACCAG CCTCTAAAGC ACAAGCCAAA AACTGTGTGA ACGGTGAACT TTGGAGTGAA 1140

GATCAATCTT GCACTTGGTG AAGAGTGCAC ATTGGACCTC AAGGCGAAAG CCAGTGGTTT 1200

GCTTGGATAA AATGTTCCCG CATGAGGCCA CAGGACTGAG GATGGGAATT TGGCAGGGCC 1260

TGAGAAGATG GTCTGACTTC CAGGCTTCCT GGTCAAAGAG AGCTACGTTT GGGCAGTTCT 1320

GCAGAGAGGA TCCTGGCAAC TAGTCCCACC TGACTAGGCC TTTAGCTGAA AGGATTTCTT 1380

GACCTCCTTG ACTGCCTCAG AGGCTGCCAG GTCAAACCCT CTTGTTTATG TGATTAGCTC 1440

AGAGCATCTC TATGAAATCT AACCCTTCCC CTCATGAGAA AGCAGTTTTC CCCACCAACA 1500

GCATAGTCAA TGAGAAAGGC AACTGTACGA AGAAAACTTC CAGTGGAACT AATATGAAAT 1560 CTATTTGCAA ATTATGGGGG GAAATAAAGC TTTTAAATTA TACAATGTAA A

Seq ID NO: 117 Protein sequence Protein Accession ft: Eos sequence 1 11 21 31 41 51 i i i i i i

MVWQQDYGTR REHHGCRLEF CRVSAGCPCL SPLTSLVIVS SSAERGEEAA EEDFETSRGG 60

FMRMKERSHA HNIKVQGEAG GADEEAAASD PEDLAKIIDE DVKGIVQKKM RITVNQTKEM 120

QKRYFQLNIG NVKCHTLDEM IIRAQTWEIV MLLDQVPGPG PTQQVDGWIY LDNGAFQTEA 180

KHKPTDVKYK ETEPVCLFTI DIRVRTAQHT RIKQKVSITS MATPFPNSFK CFTCENAGDN 240

YNCNRWAEDK WCPQNTQYCL TVHHFTSHGR STSITKKCAS RSECHFVGCH HSRDSEHTEC 300 RSCCEGMICN VELPTNHTNA VFAVMHAQRT SGSSAPTLYL PVLAWVFVLP LL

Seq ID NO: 118 DNA sequence

Nucleic Acid Accession ft: XM_0386S9.6

Coding sequence: 528-1688

1 11 21 31 41 51

I I I I I I

AGTAGGGAGG TGGGCAGGAG CCAGTGATGA CGGAATGGCA ATCACATTTG ACCTCTGATC 60

TGTTTATTTC CTCCTCCTTG ACGTCTCCAT ATAAATGTTA CACGGGCATC CCCACACTCG 120

GATACGCACC CACAGTGGCT GATTCGGGGG TAACCGTGTC ATTTGCTTGC AACACTGGCA 180

CCTCTGCCCT GCACCCCGGG AGTGAGCAGT GAGTGAGGCT CGGGTCTGGG CGCTGGCTCC 240

GAATCTTCGG GCTGGGAGAG ACTCCACCAT CTGGGGGCGG CCTGGGGGAG CAGCCTTAGT 300

GTCTTCCTGC TGATGCAATC CGCTAGGTCG CGAGTCTCCG CCGCGAGAGG GCCGGTCTGC 360

AATCCAGCCC GCCACGTGTA CTCGCCGCCG CCTCGGGCAC TGCCCCAGGT CTTGCTGCAG 420

CCGGGACCGC GCTCTGCAGC CGCAGACCCG GTCCACACGG CCAGGGGCTA CGACCCTTGG 480

GATCTGCCCT CCGCTCAGCT CGAGCTTCCC TCGTGGCCGA CGGAACAATG AAGGATTGCA 540

GTAACGGATG CTCCGCAGAG TGTACCGGAG AAGGAGGATC AAAAGAGGTG GTGGGGACTT 600

TΓAAGGCΓAA AGACCTAAΓA GTCACACCAG CΓACCATTTT AAAGGAAAAA CCAGACCCCA 66O

ATAATCTGGT TTTTGGAACT GTGTTCACGG ATCATATGCT GACGGTGGAG TGGTCCTCAG 720

AGTTTGGATG GGAGAAACCT CATATCAAGC CTCTTCAGAA CCTGTCATTG CACCCTGGCT 780

CATCAGCTTT GCACTATGCA GTGGAATTAT TTGAAGGATT GAAGGCATTT CGAGGAGTAG 840

ATAATAAAAT TCGACTGTTT CAGCCAAACC TCAACATGGA TAGAATGTAT CGCTCTGCTG 900

TGAGGGCAAC TCTGCCGGTA TTTGACAAAG AAGAGCTCTT AGAGTGTATT CAACAGCTTG 960

TGAAATTGGA TCAAGAATGG GTCCCATATT CAACATCTGC TAGTCTGTAT ATTCGTCCTA 1020

CATTCATTGG AACTGAGCCT TCTCTTGGAG TCAAGAAGCC TACCAAAGCC CTGCTCTTTG 1080

TACTCTTGAG CCCAGTGGGA CCTTATTTTT CAAGTGGAAC CTTTAATCCA GTGTCCCTGT 1140

GGGCCAATCC CAAGTATGTA AGAGCCTGGA AAGGTGGAAC TGGGGACTGC AAGATGGGAG 1200

GGAATTACGG CTCATCTCTT TTTGCCCAAT GTGAAGCAGT AGATAATGGG TGTCAGCAGG 1260

TCCTGTGGCT CTATGGAGAG GACCATCAGA TCACTGAAGT GGGAACTATG AATCTTTTTC 1320

TTTACTGGAT AAATGAAGAT GGAGAAGAAG AACTGGCAAC TCCTCCACTA GATGGCATCA 1380

TTCTTCCAGG AGTGACAAGG CGGTGCATTC TGGACCTGGC ACATCAGTGG GGTGAATTTA 1440

AGGTGTCAGA GAGATACCTC ACCATGGATG ACTTGACAAC AGCCCTGGAG GGGAACAGAG IS00

TGAGAGAGAT GTTTGGCTCT GGTACAGCCT GTGTTGTTTG CCCAGTTTCT GATATACTGT 1560

ACAAAGGCGA GACAATACAC ATTCCAACTA TGGAGAATGG TCCTAAGCTG GCAAGCCGCA 1620

TCTTGAGCAA ATTAACTGAT ATCCAGTATG GAAGAGAAGA GAGCGACTGG ACAATTGTGC 1680

TATCCTGAAT GGAAAATAGA GGATACAATG GAAAATAGAG GATACCAACT GTATGCTACT 1740

GGGACAGACT GTTGCATTTG AATTGTGATA GATTTCTTTG GCTACCTGTG CATAATGTAG 1800

TTTGTAGTAT CAATGTGTTA CAAGAGTGAT TGTTTCTTCA TGCCAGAGAA AATGAATTGC 1860

AATCATCAAA TGGTGTTTCA^' TAACTTGGTA GTAGTAACTT ACCTTACCTT ACCTAGAAAA 1920

ACATTAATGT AAGCCATATA ACATGGGATT TTCCTCAATG ATTTTAGTGC CTCCTTTTGT 1980

ACTTCACTCA GATACTAAAT AGTAGTTTAT TCTTTAATAT AAGTTACATT CTGCTCCTCA 2040

AACAAATGCA ATTTTTTGTG TGTGTTTGAA AGCTAATTTG AGAAAATTTC ATAGGTTACA 2100

TTTCCTGCAG CCTATCTTTA TCCACAGAAA GTGTTTTCTT TTTTTTAAAT CAAGACTTTT 2160

AAAACTGGAT TTCCTCCCAT CACTGTTTTT TGAAGGTCCT CCAAGTCCGT GTTAAGGTAA 2220

ATATCTGTTT TCTTCCTGAT GTCACAGCCT GAGCATACTC TGTGCATTAG GAAGACCTGA 2280

GTGCATTTCC CACCATTGTC CTTTCCACAT TATGTTGTAG CTGGCTGGCT GTCAGGCGAC 2340

TACAAGACTG AGGGTCTTGT GCCTTATAGA TCTTTGTATC CCCCATGGCT GACATATAGT 2400

AGGTACTCAG TAAATGGTTT TATAATGAAT CAGTGAACAT TTTGCTTCTA TAGAAGTGTA 2460

CCTTCTTTGT TTCTATATTA TGAAACCTCT TTATTAGAAT TTGTGATTGA TTCTGACAGT 2520

GTATAGATTT ACCTTATATT GTCTTTATTT TCCATGAGCT ACTAAGTCAT TAGAGATACT 2580 CTGAAGCATA GTTAGTTTAG GAAATCACTT CATATTGATT GTATTAGAAT TATCTTGGAA 2640

TTGAAGATAT ATCCCTAGAG CAGGGGACCC CAACCCCCAG GCCATGGGCC ACACAGCAGG 2700

AAGAGGTGAG TGGTGGGCCA TTGAGGAGCT TCATCTGTAT TTATGGCTAC TTCCCATCAC 2760

TCGAATTACC ACCTGAACTC CACCTCTTGT CAGCTCAGTG GCAGCATTAG ATTCTCATAG 2820

GAGCACAAAT CCTATTGTGA ACTCTGCATG CAAGGGATCT AGGCTATGCG CTCCTTATGA 2880

GAATCTAATG CTTGATGACC TGAGGTGTAA CAGTTTCATC CTGAAACCAC CCTTCACCCT 2940

GCAGTCTGTG GAAAAATTGT CTTCCACAAA ACTGGTCCCT GGTGCCAAAA ATGTTGGGGA 3000

CCACTGCTCT AGAGAGAGGT CATGATATCA TACCAACCAA ATGGAAATGA CAAATGTTTT 3060

ATGTCAAGTG TTAATTGCAG AAATAAATCT TTTTTTTTTT TTTTTGGTAG AAAACAAAGA 3120

GGCATACTCT GATTTTTATA CTCTGTTTTT GCAGGTGCTC TTTTCTTTGA ATGGAGATTT 3180

GATGAGCAAG TGGTTAGGAT GCAGGGAGAG CTACTATGGG TGATATTTTC CTTGTTTAGG 3240

AGCTGTGAGT TAAAATTGTA TCCTTTGTGG TTTATCTAAG GAAAGTCAAA TCTTGACAGA 3300

AAACATTTTT CCTTGGAAGG TCAACTCTCA GACATTGTAT TTTGGTTTCC CTCAGTCCTC 3360

ATAACTTCCT TCTTGCTGAA CATATTTTAT TCTCTTTTCA GAGAAGGAAA ATAAAAAGGA 3420

TTCTAAAAGT TTGATGCATT GGAAAAATTT CCTTGAGGCA TTTAGCAACA CATAGAAAAT 3480

GGGCTTTGAT TCTTTTCCAA AACTTTTAGC CATAGGGTCT TTTATAGAGA GGGATAGTAA 3540

AATGAAAATT GAGAAATATA AGATGAAAAG GAATGATAAA AATATCTTTT AGGGGGCTTT 3600

TAATTGGTGA TCTGAAATCT TGGGAGAAGC TGTTCTTTTC AGGCCTGAGG TGCTCTTGAC 3660

TGTCGCCTGC GCACTGTGTA CCCCGAGCAA CATTCTAAGG GTGTGCTTTC GCCTTGGCTA 3720

ACTCCTTTGA CCTCATTCTT CATATAGTAG TCTAGGAAAA AGTTGCAGGT AATTTAAACT 3780

GTCTAGTGGT ACATAGTAAC TAAATTTCTA TTCCTATGAG AAATGAGAAT TATTTATTTG 3840

CCATCAACAC ATTTTATACT TTGCATCTCC AAATTTATTG TGGCGAGACT TGTCCATTGT 3900

GAAAGTTAGA GAACATTATG TTTGTATCAT TTCTTTCATA AAACCTCAAG AGCATTTTTA 3960

AGCCCTTTTC ATCAGACCCA GTGAAAACTA AGGATAGATG TTTAAAAACT GGAGGTCTCC 4020

TGATAAGGAG AACACAATCC ACCATTGTCA TTTAAGTAAT AAGACAGGAA ATTGACCTTG 4080

ACGCTTTCTT GTTAAATAGA TTTAACAGGA A^'CATCTGCAC ATCTTTTTTC CTTGTGCACT 4140

ATTTGTTTAA TTGCAGTGGA TTAATACAGC AAGAGTGCCA CATTATAACT AGGCAATTAT 4200

CCATTCTTCA AGACTTAGTT ATTGTCACAC TAATTGATCG TTTAAGGCAT AAGATGGTCT 4260

AGCATTAGGA ACATGTGAAG CTAATCTGCT CAAAAAGATC AACAAATTAA TATTGTTGCT 4320

GATATTTGCA TAATTGGCTG CAATTATTTA ATGTTTAATT GGGTTGATCA AATGAGATTC 4380

AGCAATTCAC AAGTGCATTA ATATAAACAG AACTGGTGGC ACTTAAAATG ATAATGATTA 4440

ACTTATATTG CATGTTCTCT TCCTTTCACT TTTTTCAGTT TCTACATTTC AGACCGAGCT 4500

TGTCAGCTTT TTTGAAAACA CATCAGTAGA AACCAAGATT TTAAAATGAA GTGTCAAGAC 4S60

AAAGGCAAAA CCTGAGCAGT TCCTAAAAAG ATTTGCTGTT AGAAATTTTC TTTGTGGCAG 4620

TCATTTATTA AGGATTCAAC TCGTGATACA CCAAAAGAAG AGTTGACTTC AGAGATGTGT 4680

TCCATGCTCT CTAGCACAGG AATGAATAAA TTTATAACAC CTGCTTTAGC CTTTGTTTTC 4740

AAAAGCACAA AGGAAAAGTG AAAGGGAAAG AGAAACAAGT GACTGAGAAG TCTTGTTAAG 4800

GAATCAGGTT TTTTCTACCT GGTAAACATT CTCTATTCTT TTCTCAAAAG ATTGCTGTAA 4860 GAAAAAATGT AAGAC

Seq ID NO: 119 Protein sequence

Protein Accession ft: XP_038659.2

1 11 21 31 41 51

1 I I I I I

MKDCSNGCSA ECTGEGGSKE WGTFKAKDL IVTPATI KE KPDPNNLVFG TVFTDHMLTV 60

EWSSEFGWEK PHIKPLQNLS LHPGSSALHY AVELFEGLKA FRGVDNKIRL FQPNLNMDRM 120

YRSAVRATLP VFDKEELLEC IQQLVKLDQE WVPYSTSASL YIRPTFIGTE PSLGVKKPTK 180

ALLFVLLSPV GPYFSSGTFN PVSLWANPKY VRAWKGGTGD CKMGGNYGSS LFAQCEAVDN 240

GCQQVLWLYG EDHQITEVGT MNLFLYWINE DGEEELATPP LDGIILPGVT RRCILDLAHQ 300

WGEFKVSERY LTMDDLTTAL EGNRVREMFG SGTACWCPV SDILYKGETI HIPTMENGPK 360 LASRILSKLT DIQYGREESD WTIVLS

Seq ID NO: 120 DNA sequence Nucleic Acid Accession ft: NM_005377 Coding sequence: 121..1194

1 11 21 31 41 51

A ICAGAGGGCG GIGTCGCGCGC TICGGTGGCCG TITGTGCGCGT GITGTGGAGTG CICCTGCTGCC 60

CCCAGCTGGA GGGGAACTAG TCTGCTCCAG GTGGCAAGCT GCGTGAGCAA GCAAGCCAAC 120

ATGGACCGCG ACTCGTACCA TCACTATTTC TACGACTATG ACGGCGGGGA GGATTTCTAC 180

CGCTCCACGA CGCCCAGCGA GGACATCTGG AAGAAATTCG AGTTGGTGCC GCCGCCCTGG 240

ACTTGGGTCC GCAGCCGGGA ACCCAGCCCT CAGCTTTGGT CTCCTGGAAC GTGGCCGGTA 300

GGGTGCGCTG GGGACGAGAC GGAATCCCAG GACTACTGGA AAGCTTGGGA CGCGAACTAC 360

GCCTCCCTCA TCCGCCGTGA CTGCATGTGG AGCGGCTTCT CCACCCAGGA GCCGCTGGAG 420

AGAGCGGTGA GTGACCTGCT TGCCGTTGGC GCGCCCTCGG GATACTCGCC CAAGGAGTTC 480

GCCACCCCCG ACTACACTCC CGAGCTCGAA GCCGGCAACC TAGCGCCCAT CTTCCCCTGT 540

TTGTTGGGCG AGCCCAAGAT CCAGGCCTGC TCCAGGTCTG AGAGCCCAAG CGACTCCGAG 600

GGTGAAGAAA TCGACGTGAC AGTAAAGAAG AGGCAGTCTT TGAGTACGCG GAAGCCAGTC 660

ATCATCGCGG TGCGTGCAGA CCTTCTGGAT CCCCGCATGA ATCTCTTCCA CATCTCCATC 720

CACCAGCAAC AGCACAACTA TGCTGCCCCT TTTCCTCCAG AAAGCTGCTT CCAAGAAGGG 780

GCTCCAAAGA GGATGCCCCC AAAAGAGGCT CTAGAGAGAG AAGCTCCAGG GGGAAAGGAT 840

GATAAGGAAG ATGAAGAGAT TGTGAGCCTC CCACCTGTAG AAAGTGAGGC TGCCCAGTCC 900

TGCCAGCCCA AACCCATCCA TTATGATACT GAGAATTGGA CCAAGAAGAA GTACCACAGC 960

TACCTGGAGC GCAAGAGACG GAATGATCAA CGTTCGCGGT TCTTGGCCCT GAGGGACGAG 1020

GTACCCGCCC TGGCCAGCTG CTCTAGGGTT TCCAAAGTAA TGATCCTAGT CAAGGCCACG 1080

GAATACTTAC ATGAACTGGC GGAAGCCGAG GAGAGGATGG CTACGGAGAA AAGGCAGCTC 1140

GAATGCCAGC GACGGCAATT GCAGAAAAGA ATTGAGTACC TCAGTAGCTA CTGACCAAAA 1200

AGCCTGACCA TTCTGTCTTA AAAAGACACA AGTTTTCTTT TTGATCTCCC TCTCCCCTTT 1260

AGTAACTTGT ACATTTTTGT TACAGCAGGA CACTCTGGAC AGTAGATTGC AGAATCGATT 1320

GCAGCCAGTG CACAAACAAT ATAAAGGCTT GCATTCTTGG AAACTTTGAA ACCCAGCTCT 1380

CTCTCTTCCC TGACTTATGG GAGTGCTTTG TGTTTTCTGG CACCTTTGGC TTCTCAGCAG 1440

GCAGCTGACT GAGGAGACTT GGGGTCTTCC TGGCTCACTA TCTCCAAAGA AAAGGCTGAC 1500

AGATGGTATG CAACAGGTGG TGGATGTTGT TGGGGGCTCC AGCCTGGAGG AAATCTCACA 1560

CTCTACATGA ACTTTAGGCT AGGAAAGGAT GTCTCTGGGG TGATGCAAGG ACAGCTGGGT 1620

GTGGACGCTC TCCTGCGGCT CCATTTTTTT CCAGGAGACA CACAAGCTGC CTTGGGTGAA 1680 AACAAGCTCA GAGACTTGAT CAACGTGGAC CATTACCTCA CTGTCAGACA CTACAGCTAG 1740 CTGAGGAGTT GGAAACCTTA CATATATGTA TATATATATG TATGTATATA TGTATATATG 1800 TATATATATA TGTATGTATA TATGTATATA TGTATATATA TATGTATGTA TATATGTATA 1860 TATGTATATA TATATGTATG TATATATGTA TATATTATGA TGTTGGCTGA CCCCCTTCCT 1920 CCCACTCTCA ATGCTGTGAC TCAGAACATT TAAGAGAACT TCGTCTGTAA GTAATTTGTC 1980 TTAAAGCCCT CTGGGCTCTC TTCTCTGAGT GAGGGAACTT TCTGTCTTCA CAAGGGACTT 2040 TGTCTCATTC TGCCTCTGTT ATGCAATGGG TTCTACAGCA CCCTTTCCCG CAGGTTAGAA 2100 ATATTTCCCT AAGACACAGG GAAATGGGTC TTAGCCTGGG GCCTGGGGAA AGTTCCCAAG 2160 CCCTGGCTCA TGAACTCAAT CCCTGCCCAG GTGTTTTCTG AGGGGCCCTT GAGGCCAATC 2220 TTTTCTCAAG ACAGTGTGAG GCACCTTAGA AGGGAGAACT GTAACACTTT CTCTTTCGCA 2280 CCTGCCTCTC ATCTCAATCC TTGACTGATG AATTTGAAGT TCTACTAGAA CCATGAAAAC 2340 TTGTTCCTTT CGTGCATCTC CAAGGAGCTT GCTGGCTCTG CAGCCACGCT TGGGCCCTCG 2400 CACCAGCCTG CAATGAATCA GATGTCTGTC ACAGAATCTG GGCCTCTCTG AAGTTTTCTG 2460 GAGAGCTGTT GGGACTCATC CAGTGCTCCA CAACGTGGAC TTGCCTCCTG GTGTGTTTTA 2520 AAGGATCCTC CAGGAGCTCT GCTTAGCCAA TCATCATGAT GGATTTTTTT 2580 GAGACGGAGT CTCAACTCTT GTCGCCCAGG CTGGAGGTTA ATGGCATGAT CTCGGCTCAC 2640 TGCAACCTCT GCCTCCCGGG TTCAAGCGAT TCTCCTGCCT GAGCCTTCCG AGTAGCTGGG 2700 ATCGCAGGCG CCTGCCACCA CGCCTAGCTA ATTTCTGTAT TTTTAGTAGA GATGGGGTTT 2760 CACCACATTG GCCAGGCTGG TCTTGACCTC CTGACCTAGG TGATCCACTG CCTCCATGAT 2820 AGATTTTGCC CCAGCTGGAC TCTGCAGCTC CACGTGGAAT CCAGGTGCCT GCCTCCAGTC 2880 TGGGAAAGTC ACCAACCCGC AGCTTGTCAT GTGGGTAACT TCTGAACCCT AAGCC

Seq ID NO: 121 Protein sequence

Protein Accession ft: NP_005368

1 11 21 31

MDRDSYHHYF YDYDGGEDFY RSTTPSEDIW KKFELVPPPW TWVRSREPSP QLWSPGTWPV 60

GCAGDETESQ DYWKAWDANY ASLIRRDCMW SGFSTQEPLE RAVSDLLAVG APSGYSPKEF 120

ATPDYTPELE AGNLAPIFPC LLGEPKIQAC SRSESPSDSE GEEIDVTVKK RQSLSTRKPV 180

IIAVRADLLD PRMNLFHISI HQQQHNYAAP FPPESCFQEG APKRMPPKEA LEREAPGGKD 240

DKEDEEIVSL PPVESEAAQS CQPKPIHYDT ENWTKKKYHS YLERKRRNDQ RSRFLALRDE 300

VPALASCSRV SKVMILVKAT EYLHELAEAE ERMATEKRQL ECQRRQLQKR IEYLSSY

Seq ID NO: 122 DNA sequence

Nucleic Acid Accession ft: AB006625.2

Coding sequence: 3S6..4750

1 11 21 31 51

I I I I

GAGGTTTGGG AGGCGCGGGA GATGTCCACC CTGGGCTGGT GGCGCCGCCG GGCGCCGGGC 60 GCCATGAGGG TGCGCTAGGC GGCTGTTCGT GCCCGAGGCT GCGCAGCACT GAGGTGAGCT 120 TTGCCTTCTT GATCTTCCGT CCTTCTTGGA GACGACTGGC GAGAGGAAGA GGGACTAGGT 180 CCAAACGCTA GGTGGCTGGG TCCAGCCGGA GACCCGCACC AAGGAGGAGA TCATCGAGCT 240 CTTGGTCCTT GAGCAGTACC TGACCATCAT CCCTGAAAAG CTCAAGCCTT GGGTGCGAGC 300 AAAAAAGCCG GAGAACTGTG AGAAGCTCGT CACTCTGCTG GAGAATTACA AGGAGATGTA 360 CCAACCAGAA GACGACAACA ACAGTGACGT GACCAGCGAC GACGACATGA CCCGGAACAG 420 AAGAGAGTCC TCACCACCTC ACTCAGTCCA TTCTTTCAGT GGTGACCGGG ACTGGGACCG 480 GAGGGGCAGA AGCAGAGACA TGGAGCCACG AGACCGCTGG TCCCACACCA GGAACCCAAG 540 AAGCAGGATG CCTCCGCGGG ATCTTTCCCT TCCTGTGGTG GCGAAAACAA GCTTTGAAAT 600 GGACAGAGAG GACGACAGGG ACTCCAGGGC TTATGAGTCC CGATCTCAGG ATGCTGAATC 660 ATACCAAAAT GTGGTGGACC TCGCTGAGGA CAGGAAACCT CACAACACAA TCCAGGACAA 720 CATGGAAAAC TACAGGAAGC TGCTCTCCCT CGGAGTGCAG CTTGCTGAAG ACGATGGCCA 780 CTCCCACATG ACGCAGGGCC ACTCATCAAG ATCCAAGAGA AGTGCCTACC CAAGCACCAG 840 TCGAGGTCTA AAAACTATGC CTGAAGCCAA AAAATCAACC CACCGGCGGG GGATTTGTGA 900 AGATGAATCT TCCCACGGAG TGATAATGGA AAAATTCATC AAGGATGTGT CACGCAGTTC 960 CAAATCGGGA AGAGCAAGGG AGTCAAGCGA CCGGTCACAG AGATTCCCCA GAATCTCAGA 1020 TGATAACTGG AAGGACATTT CATTGAACAA GAGGGAGTCA GTGATCCAGC AGCGGGTTTA 1080 TGAAGGGAAT GCATTTAGGG GAGGCTTTAG GTTTAATTCA ACCCTTGTTT CCAGAAAGAG ' 1140 AGTTCTTGAA AGAAAGAGGC GCTATCATTT TGACACAGAT GGGAAGGGCT CGATTCACGA 1200 TCAAAAAGGC TGTCCCAGGA AGAAGCCCTT TGAATGTGGT AGTGAGATGA GAAAAGCCAT 1260 GAGCGTGAGC AGCCTGAGCA GCCTCAGCTC CCCCTCCTTT ACCGAGTCAC AGCCAATTGA 1320 TTTTGGGGCA ATGCCATATG TATGTGATGA GTGTGGGAGG TCGTTCAGTG TCATCTCAGA 1380 ATTTGTTGAG CACCAGATCA TGCATACTAG AGAGAACCTC TATGAGTATG GTGAGTCCTT 1440 TATCCACAGT GTGGCTGTCA GTGAAGTTCA GAAAAGTCAG GTTGGAGGGA AACGTTTTGA 1500 ATGTAAGGAC TGTGGAGAGA CCTTCAATAA GAGTGCCGCC TTGGCTGAAC ATCGGAAGAT 1560 TCATGCTAGA GGTTATCTTG TGGAATGTAA GAATCAGGAA TGTGAGGAAG CCTTCATGCC 1620 TAGCCCCACC TTTAGTGAGC TTCAGAAAAT ATATGGCAAA GACAAATTCT ACGAGTGCAG 1680 GGTGTGTAAG GAAACCTTCC TCATAGTTC TGCCCTGATT GAGCACCAGA AAATCCACTT 1740 TGGGGATGAC AAAGATAATG AGCGTGAACA TGAACGTGAA CGTGAACGTG AGCGCGGGGA 1800 AACCTTTAGG CCCAGCCCAG CCCTTAATGA GTTTCAGAAA ATGTATGGTA AAGAGAAAAT 1860 GTACGAATGT AAGGTGTGTG GGGAGACTTT CCTTCATAGC TCATCCCTGA AAGAACATCA 1920 GAAAATCCAT ACTAGAGGGA ACCCATTTGA AAACAAGGGT AAAGTGTGTG AGGAAACCTT 1980 TATTCCTGGT CAGTCCCTTA AAAGGCGTCA GAAAACTTAC AATAAGGAGA AGCTCTGTGA 2040 CTTTACAGAT GGCCGGGATG CCTTCATGCA AAGCTCAGAG CTCAGTGAGC ATCAGAAAAT 2100 TCATTCTCGA AAGAACCTCT TTGAAGGCAG AGGGTATGAG AAATCTGTCA TTCATAGTGG 2160 GCCATTCACT GAATCTCAGA AGAGTCATAC TATAACAAGA CCTCTTGAAA GTGATGAGGA 2220 CGAAAAGGCG TTCACCATTA GCTCTAACCC CTATGAAAAC CAGAAGATTC CCACTAAGGA 2280 AAATGTCTAC GAGGCAAAAT CATATGAGAG GTCTGTTATT CATAGCTTAG CCTCTGTGGA 2340 AGCTCAGAAA AGTCACAGTG TAGCAGGGCC CAGTAAACCA AAAGTAATGG CAGAGTCTAC 2400 CATTCAGAGC TTCGATGCTA TCAACCATCA GAGAGTTCGT GCTGGAGGGA ACACCTCTGA 2460 AGGAAGGGAA TACAGTAGGT CTGTTATCCA TAGCTTAGTG GCTTCCAAAC CTCCAAGAAG 2520 TCACAATGGA AATGAATTGG TGGAATCTAA TGAGAAGGGA GAATCCTCCA TTTATATCTC 2S80 AGACCTTAAT GATAAGCGAC AGAAGATTCC TGCCAGAGAG AACCCTTGTG AAGGGGGCAG 2640 TAAGAATCGC AACTATGAAG ACTCTGTCAT ACAGAGTGTA TTCCGTGCCA AACCTCAGAA 2700 AAGTGTTCCT GGAGAGGGAT CTGGTGAGTT TAAGAAGGAT GGCGAATTCT CTGTTCCCAG 2760 CTCAAATGTC CGTGAATACC AGAAGGCTCG TGCTAAAAAG AAATACATTG AGCATAGGAG 2820 CAATGAGACC TCTGTAATTC ACTCTCTGCC TTTTGGTGAA CAAACATTTC GCCCTCGAGG 2880

GATGCTCTAT GAATGTCAGG AGTGTGGGGA GTGCTTTGCT CATAGCTCTG ACCTCACTGA 2940

GCACCAGAAG ATTCATGATA GGGAGAAGCC CTCTGGAAGC AGAAACTATG AATGGTCTGT 3000

CATTCGCAGC TTGGCCCCTA CTGACCCTCA AACAAGTTAC GCCCAAGAGC AGTATGCTAA 3060

AGAGCAAGCG CGGAACAAAT GTAAGGACTT CAGACAATTT TTTGCTACCA GCGAAGACCT 3120

CAACACAAAC CAGAAAATCT ATGACCAAGA GAAGTCTCAT GGCGAGGAGT CTCAAGGCGA 3180

GAATACTGAT GGGGAGGAGA CCCACAGCGA GGAGACCCAT GGTCAGGAGA CAATTGAAGA 3240

CCCTGTCATT CAAGGCTCAG ACATGGAAGA CCCTCAGAAG GATGACCCTG ATGACAAAAT 3300

CTATGAATGT GAGGACTGTG GCCTGGGCTT TGTGGATCTC ACAGACCTCA CAGACCATCA 3360

GAAAGTCCAC AGCAGGAAGT GCCTGGTTGA CAGTCGGGAG TACACACATT CTGTAATTCA 3420

CACCCATTCC ATCAGCGAGT ATCAGAGAGA TTACACTGGA GAGCAGCTGT ATGAATGTCC 3480

AAAGTGTGGG GAATCTTTTA TTCATAGCTC ATTCCTTTTC GAGCATCAGA GAATCCATGA 3540

ACAAGACCAG TTGTATTCCA TGAAGGGGTG TGATGATGGT TTTATTGCCC TCTTGCCCAT 3600

GAAGCCACGG AGGAATCGTG CTGCAGAGAG GAATCCTGCT CTTGCTGGGT CGGCCATTCG 3660

ATGCCTTTTG TGTGGACAAG GCTTCATTCA TAGCTCTGCC CTTAATGAGC ATATGAGACT 3720

TCATAGGGAA GATGATTTAC TGGAGCAGAG CCAGATGGCT GAGGAAGCTA TCATTCCAGG 3780

CTTAGCCCTC ACTGAGTTTC AGAGAAGTCA GACCGAAGAG AGACTCTTTG AATGTGCAGT 3840

CTGTGGAGAA TCTTTCGTCA ACCCAGCAGA ACTTGCAGAT CACGTAACTG TTCATAAGAA 3900

TGAGCCCTAT GAGTACGGGT CCTCCTATAC TCACACCTCA TTTCTTACTG AGCCCCTCAA 3960

AGGAGCTATA CCATTCTATG AATGCAAGGA TTGTGGTAAG TCCTTTATTC A AGCACAGT 4020

CCTCACTAAA CATAAGGAGC TTCATCTGGA AGAAGAAGAA GAAGATGAAG CAGCAGCAGC 4080

TGCAGCAGCA GCAGCCCAGG AAGTTGAAGC CAATGTCCAT GTTCCACAAG TAGTTCTGAG 4140

GATTCAGGGC TTAAACGTAG AGGCTGCTGA GCCAGAAGTG GAGGCTGCCG AGCCAGAAGT 4200

GGAGGCTGCT GAGCCAGAAG TGGAGGCTGC TGAGCCAAAC GGAGAGGCTG AAGGGCCAGA 4260

TGGAGAGGCT GCAGAGCCCA TTGGAGAGGC TGGACAGCCA AATGGAGAGG CCGAGCAGCC 4320

AAATGGGGAT GCTGATGAGC CAGATGGTGC AGGTATTGAA GACCCAGAAG AAAGAGCTGA 4380

AGAGCCAGAG GGAAAAGCTG AAGAGCCAGA GGGAGATGCC GACGAGCCTG ACGGTGTGGG 4440

AATTGAAGAC CCAGAAGAAG GTGAAGATCA AGAGATTCAG GTAGAAGAAC CATACTATGA 4500

CTGCCATGAA TGCACAGAAA CCTTCACTTC CAGCACAGCA TTCAGTGAAC ACCTGAAAAC 4560

TCATGCCAGC ATGATCATAT TTGAGCCTGC AAATGCCTTT GGGGAGTGCT CAGGCTACAT 4620

CGAACGTGCC AGCACCAGCA CAGGTGGTGC CAATCAAGCT GATGAGAAGT ACTTCAAATG 4680

TGACGTCTGT GGGCAGCTCT TCAATGACCG CCTGTCCCTC GCCAGACACC AGAATACCCA 4740

CACTGGCTGA GGGCATGGGG TAAAGGTTAG AAAACCTTCA CCTAGGACTT GACCCTTACC 4800

AAACCACAGA GAATCCAAAC CAATCCATGA TAATGTCAGT AGGAGACTTA ACCTTAGTGT 4860

GTTACACACC TGACTTAACA TCTCTAAACT CAGATTGAAA AGAGACCGAA TGTGCAGATT 4920

CCACAGTCTT AAGCTTTCCC CTTCAGATGT CAGTGTCTGC ATGTGGGAAA GCCATAGCAC 4980

ACATCTTACC TTTCCAAGTA ATCAGATTGA GAAAACCCTA TGAGTATTCC AGACTACAGA 5040

GTTTGCCCAA ATCAACTGTA AATGACACTT GTGTAACGTA TATATAGTGT TTCATGAGGT 5100

GTATATAAAA TAGCAAATTA TGACAGAACA GTGATCACAT ATATTTGGAT TTATATGATA 5160

TACAGTTACA GTTTACTCTG CAGAGGTACC TTACCTGGTA TTCTTTGAAT _TττχτTTTTT 5220

TTTGGAGGAG GAAGAGAGCA ACAAATTTGA TTATATTTTT AAGTGTCTTA GATCCTGAGA 5280

AAGATTTATT GTGCATTATT TGAACCCTGT CAATATCTTT TTGAGTAATT GTTTTGTTTC 5340

TTACCCTTAA ATAGTCTTGT GAAGCTGTAG GCATGATAGA TAACATGGCT TTTACTCCTT 5400

ACTGTTTGAA AAGATAAGTA CTTTAGCTTC TTTCTGCAGC CATTTCATCT GCACCAACAC 5460

TTTGGAACCT AATACTGTGT AAGGCTTTAC AATATACGGA TTGGCTTTTT GTGACCCAGA 5520

TTGATTGGTT GCCACATGTT ATGTTTGTTG AAGTGGTTCT CATGCAAAAA TATTACACAT 5580

TTGTGTTCTG GGTTTTTTTT TTTTTTTAAC CAACTCAATA TGTGTTTGAT GATAGTGAAT 5640

TGATAAAACC CGAAGCTTTT CCCTGTAAAT CTTACATCTT TGCCTTTAAA GAATGGGTTA 5700

CAACCATCAC TAGATCACAG TAGTGCCTAA TGAAGGTTGA GAACCGTAGG AGAGGCTCTC 5760

ATGCTGTAAA TAATGTTGCA GGCTAATAAC CTTTCATCAC TTCCTTTGTG CGCTTCCTGC 5820

CTTAAGTGAC AAGTAGCAAC ATGGCTTGGG TCCCCTGTGC AGCATCAGCT TATGCTGCCA 5880

CAAGTCAGTT TGCACCCTAG GTGCCCAGGA GCTAGTATCC TTAGATCTTT CTATCGCTAA 5940 CTTAATTCTC TTCGTTATTT ATCTGACCCT CTAACTCCAT GTCTAACTTG CATT

Seq ID NO: 123 Protein sequence Protein Accession ft: BAA22956.2 1 11 21 31 41 51

I I I I I I

VQTLGGWVQP ETRTKEEIIE LLVLEQYLTI IPEKLKPWVR AKKPENCEKL VTLLENYKEM 60

YQPEDDNNSD VTSDDDMTRN RRESSPPHSV HSFSGDRDWD RRGRSRDMEP RDRWSHTRNP 120

RSRMPPRDLS LP AKTSFE MDREDDRDSR AYESRSQDAE SYQNWDLAE DRKPHNTIQD 180

NMENYRKLLS LGVQLAEDDG HSHMTQGHSS RSKRSAYPST SRGLKTMPEA KKSTHRRGIC 240

EDESSHGVIM EKFIKDVSRS SKSGRARESS DRSQRFPRMS DDNWKDISLN KRESVIQQRV 300

YEGNAFRGGF RFNSTLVSRK RVLERKRRYH FDTDGKGSIH DQKGCPRKKP FECGSEMRKA 360

MSVSSLSSLS SPSFTESQPI DFGAMPYVCD ECGRSFSVIS EFVEHQIMHT RENLYEYGES 420

FIHSVAVSEV QKSQVGGKRF ECKDCGETFN KSAALAEHRK IHARGYLVEC KNQECEEAFM 480

PSPTFSELQK IYGKDKFYEC RVCKETFLHS SALIEHQKIH FGDDKDNERE HERERERERG 540

ETFRPSPALN EFQKMYGKEK MYECKVCGET FLHSSSLKEH QKIHTRGNPF ENKGKVCEET 600

FIPGQSLKRR QKTYNKEKLC DFTDGRDAFM QSSELSEHQK IHSRKNLFEG RGYEKSVIHS 660

GPFTESQKSH TITRPLESDE DEKAFTISSN PYENQKIPTK ENVYEAKSYE RSVIHSLASV 720

EAQKSHSVAG PSKPKVMAES TIQSFDAINH QRVRAGGNTS EGREYSRSVI HSLVASKPPR 780

SHNGNELVES NEKGESSIYI SDLNDKRQKI PARENPCEGG SKNRNYEDSV IQSVFRAKPQ 840

KSVPGEGSGE FKKDGEFSVP SSNVREYQKA RAKKKYIEHR SNETSVIHSL PFGEQTFRPR 900

GMLYECQECG ECFAHSSDLT EHQKIHDREK PSGSRNYEWS VIRSLAPTDP QTSYAQEQYA 960 KEQARNKCKD FRQFFATSED LNTNQKIYDQ EKSHGEESQG ENTDGEETHS EETHGQETIE 1020

DPVIQGSDME DPQKDDPDDK IYECEDCGLG FVDLTDLTDH QKVHSRKCLV DSREYTHSVI 1080

HTHSISEYQR DYTGEQLYEC PKCGESFIHS SFLFEHQRIH EQDQLYSMKG CDDGFIALLP 1140

MKPRRNRAAE RNPALAGSAI RCLLCGQGFI HSSALNEHMR LHREDDLLEQ SQMAEEAIIP 1200

GLALTEFQRS QTEERLFECA VCGESFVNPA ELADHVTVHK NEPYEYGSSY THTSFLTEPL 1260

KGAIPFYECK DCGKSFIHST VLTKHKELHL EEEEEDEAAA AAAAAAQEVE ANVHVPQWL 1320

RIQGLNVEAA EPEVEAAEPE VEAAEPEVEA AEPNGEAEGP DGEAAEPIGE AGQPNGEAEQ 1380

PNGDADEPDG AGIEDPEERA EEPEGKAEEP EGDADEPDGV GIEDPEEGED QEIQVEEPYY 1440

DCHECTETFT SSTAFSEHLK THASMIIFEP ANAFGECSGY IERASTSTGG ANQADEKYFK 1500 CDVCGQLFND RLSLARHQNT HTG Seq ID NO: 124 DNA sequence Nucleic Acid Accession ft: NM_007196 Coding sequence: 180..1962 1 11 21 31 51

GTTCCCAGAA GCTCCCCAGG CTCTAGTGCA GGAGGAGAAG GAGGAGGAGC AGGAGGTGGA 60

GATTCCCAGT TAAAAGGCTC CAGAATCGTG TACCAGGCAG AGAACTGAAG TACTGGGGCC 120

TCCTCCACTG GGTCCGAATC AGTAGGTGAC CCCGCCCCTG GATTCTGGAA GACCTCACCA 180

TGGGACGCCC CCGACCTCGT GCGGCCAAGA CGTGGATGTT CCTGCTCTTG CTGGGGGGAG 240

CCTGGGCAGG ACACTCCAGG GCACAGGAGG ACAAGGTGCT GGGGGGTCAT GAGTGCCAAC 300

CCCATTCGCA GCCTTGGCAG GCGGCCTTGT TCCAGGGCCA GCAACTACTC TGTGGCGGTG 360

TCCTTGTAGG TGGCAACTGG GTCCTTACAG CTGCCCACTG TAAAAAACCG AAATACACAG 420

TACGCCTGGG AGACCACAGC CTACAGAATA AAGATGGCCC AGAGCAAGAA ATACCTGTGG 480

TTCAGTCCAT CCCACACCCC TGCTACAACA GCAGCGATGT GGAGGACCAC AACCATGATC 540

TGATGCTTCT TCAACTGCGT GACCAGGCAT CCCTGGGGTC CAAAGTGAAG CCCATCAGCC 600

TGGCAGATCA TTGCACCCAG CCTGGCCAGA AGTGCACCGT CTCAGGCTGG GGCACTGTCA 660

CCAGTCCCCG AGAGAATTTT CCTGACACTC TCAACTGTGC AGAAGTAAAA ATCTTTCCCC 720

AGAAGAAGTG TGAGGATGCT TACCCGGGGC AGATCACAGA TGGCATGGTC TGTGCAGGCA 780

GCAGCAAAGG GGCTGACACG TGCCAGGGCG ATTCTGGAGG CCCCCTGGTG TGTGATGGTG 840

CACTCCAGGG CATCACATCC TGGGGCTCAG ACCCCTGTGG GAGGTCCGAC AAACCTGGCG 900

TCTATACCAA CATCTGCCGC TACCTGGACT GGATCAAGAA GATCATAGGC AGCAAGGGCT 960

GATTCTAGGA TAAGCACTAG ATCTCCCTTA ATAAACTCAC AACTCTC

Seq ID NO: 125 Protein sequence

Protein Accession ft: NP_009127

1 11 21 3~i 41 51

I I I I I I

MGRPRPRAAK TWMFLLLLGG AWAGHSRAQE DKVLGGHECQ PHSQPWQAAL FQGQQLLCGG 60

VLVGGNWVLT AAHCKKPKYT VRLGDHSLQN KDGPEQEIPV VQSIPHPCYN SSDVEDHNHD 120

LMLLQLRDQA SLGSKVKPIS LADHCTQPGQ KCTVSGWGTV TSPRENFPDT LNCAEVKIFP 180

QKKCEDAYPG QITDGMVCAG SSKGADTCQG DSGGPLVCDG ALQGITSWGS DPCGRSDKPG 240 VYTNICRYLD WIKKIIGSKG

Seq ID NO: 126 DNA sequence

Nucleic Acid Accession ft: NM_014791.1

Coding sequence: 171..2126

1 11 21 31

I I I I

TTGGCGGGCG GAAGCGGCCA CAACCCGGCG ATCGAAAAGA TTCTTAGGAA CGCCGTACCA 60 GCCGCGTCTC TCAGGACAGC AGGCCCCTGT CCTTCTGTCG GGCGCCGCTC AGCCGTGCCC 120 TCCGCCCCTC AGGTTCTTTT TCTAATTCCA AATAAACTTG CAAGAGGACT ATGAAAGATT 180 ATGATGAACT TCTCAAATAT TATGAATTAC ATGAAACTAT TGGGACAGGT GGCTTTGCAA 240 AGGTCAAACT TGCCTGCCAT ATCCTTACTG GAGAGATGGT AGCTATAAAA ATCATGGATA 300 AAAACACACT AGGGAGTGAT TTGCCCCGGA TCAAAACGGA GATTGAGGCC TTGAAGAACC 360 TGAGACATCA GCATATATGT CAACTCTACC ATGTGCTAGA GACAGCCAAC AAAATATTCA 420 TGGTTCTTGA GTACTGCCCT GGAGGAGAGC TGTTTGACTA TATAATTTCC CAGGATCGCC 480 TGTCAGAAGA GGAGACCCGG GTTGTCTTCC GTCAGATAGT ATCTGCTGTT GCTTATGTGC 540 ACAGCCAGGG CTATGCTCAC AGGGACCTCA AGCCAGAAAA TTTGCTGTTT GATGAATATC 600 ATAAATTAAA GCTGATTGAC TTTGGTCTCT GTGCAAAACC CAAGGGTAAC AAGGATTACC 660 ATCTACAGAC ATGCTGTGGG AGTCTGGCTT ATGCAGCACC TGAGTTAATA CAAGGCAAAT 720 CATATCTTGG ATCAGAGGCA GATGTTTGGA GCATGGGCAT ACTGTTATAT GTTCTTATGT 780 GTGGATTTCT ACCATTTGAT GATGATAATG TAATGGCTTT ATACAAGAAG ATTATGAGAG 840 GAAAATATGA TGTTCCCAAG TGGCTCTCTC CCAGTAGCAT TCTGCTTCTT CAACAAATGC 900 TGCAGGTGGA CCCAAAGAAA CGGATTTCTA TGAAAAATCT ATTGAACCAT CCCTGGATCA 960 TGCAAGATTA CAACTATCCT GTTGAGTGGC AAAGCAAGAA TCCTTTTATT CACCTCGATG 1020 ATGATTGCGT AACAGAACTT TCTGTACATC ACAGAAACAA CAGGCAAACA ATGGAGGATT 1080 TAATTTCACT GTGGCAGTAT GATCACCTCA CGGCTACCTA TCTTCTGCTT CTAGCCAAGA 1140 AGGCTCGGGG AAAACCAGTT CGTTTAAGGC TTTCTTCTTT CTCCTGTGGA CAAGCCAGTG 1200 CTACCCCATT CACAGACATC AAGTCAAATA ATTGGAGTCT GGAAGATGTG ACCGCAAGTG 1260 ATAAAAATTA TGTGGCGGGA TTAATAGACT ATGATTGGTG TGAAGATGAT TTATCAACAG 1320 GTGCTGCTAC TCCCCGAACA TCACAGTTTA CCAAGTACTG GACAGAATCA AATGGGGTGG 1380 AATCTAAATC ATTAACTCCA GCCTTATGCA GAACACCTGC AAATAAATTA AAGAACAAAG 1440 AAAATGTATA TACTCCTAAG TCTGCTGTAA AGAATGAAGA GTACTTTATG TTTCCTGAGC 1500 CAAAGACTCC AGTTAATAAG AACCAGCATA AGAGAGAAAT ACTCACTACG CCAAATCGTT 1560 ACACTACACC CTCAAAAGCT AGAAACCAGT GCCTGAAAGA AACTCCAATT AAAATACCAG 1620 TAAATTCAAC AGGAACAGAC AAGTTAATGA CAGGTGTCAT TAGCCCTGAG AGGCGGTGCC 1680 GCTCAGTGGA ATTGGATCTC AACCAAGCAC ATATGGAGGA GACTCCAAAA AGAAAGGGAG 1740 CCAAAGTGTT TGGGAGCCTT GAAAGGGGGT TGGATAAGGT TATCACTGTG CTCACCAGGA 1800 GCAAAAGGAA GGGTTCTGCC AGAGACGGGC CCAGAAGACT AAAGCTTCAC TATAATGTGA 1860 CTACAACTAG ATTAGTGAAT CCAGATCAAC TGTTGAATGA AATAATGTCT ATTCTTCCAA 1920 AGAAGCATGT TGACTTTGTA CAAAAGGGTT ATACACTGAA GTGTCAAACA CAGTCAGATT 1980 TTGGGAAAGT GACAATGCAA TTTGAATTAG AAGTGTGCCA GCTTCAAAAA CCCGATGTGG 2040 TGGGTATCAG GAGGCAGCGG CTTAAGGGCG ATGCCTGGGT TTACAAAAGA TTAGTGGAAG 2100 ACATCCTATC TAGCTGCAAG GTATAATTGA TGGATTCTTC CATCCTGCCG GATGAGTGTG 2160 GGTGTGATAC AGCCTACATA AAGACTGTTA TGATCGCTTT GATTTTAAAG TTCATTGGAA 2220 CTACCAACTT GTTTCTAAAG AGCTATCTTA AGACCAATAT CTCTTTGTTT TTAAACAAAA 2280 GATATTATTT TGTGTATGAA TCTAAATCAA GCCCATCTGT CATTATGTTA CTGTCTTTTT 2340 TAATCATGTG GTTTTGTATA TTAATAATTG TTGACTTTCT TAGATTCACT TCCATATGTG 2400 AATGTAAGCT CTTAACTATG TCTCTTTGTA ATGTGTAATT TCTTTCTGAA ATAAAACCAT 2460 TTGTGAATAT

Seq ID NO: 127 Protein sequence Protein Accession ft: NP_055606.1 1 11 21 31

I I MKDYDELLKY YELHETIGTG GFAKVKLACH ILTGEMVAIK IMDKNTLGSD LPRIKTEIEA 60

LKNLRHQHIC QLYHVLETAN KIFMVLEYCP GGELFDYIIS QDRLSEEETR WFRQIVSAV 120

AYVHSQGYAH RDLKPENLLF DEYHKLKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI 180

QGKSYLGSEA DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMRGKYDVPK WLSPSSILLL 240

QQMLQVDPKK RISMKNLLNH PWIMQDYNYP VEWQSKNPFI HLDDDCVTEL SVHHRNNRQT 300

MEDLISLWQY DHLTATYLLL LAKKARGKPV RLRLSSFSCG QASATPFTDI KSNNWSLEDV 360

TASDKNYVAG LIDYDWCEDD LSTGAATPRT SQFTKYWTES NGVESKSLTP ALCRTPANKL 420

KNKENVYTPK SAVKNEEYFM FPEPKTPVNK NQHKREILTT PNRYTTPSKA RNQCLKETPI 480

KIPVNSTGTD KLMTGVISPE RRCRSVELDL NQAHMEETPK RKGAKVFGSL ERGLDKVITV 540

LTRSKRKGSA RDGPRRLKLH YNVTTTRLVN PDQLLNEIMS ILPKKHVDFV QKGYTLKCQT 600 QSDFGKVTMQ FELEVCQLQK PDWGIRRQR LKGDAWVYKR LVEDILSSCK V

Seq ID NO: 128 DNA sequence Nucleic Acid Accession ft : EOS sequence Coding sequence: 169-1323

1 11 21 31 41 SI

I I I I I I

GGGATCCTTT CTGGAATGGA GGTCTTATGA GCTGCTATTG AACACGGCAG AGCCTGTTGG 60

TGACCTGCAC ACAGGAGCCC TCCAGTCAGT ACTGATTGAA TTACTCAAGG CTGCCTCTCT 120

GCAAAGTTGA GCACTACAGG ACGTGGGGAC TGGGCATTTC CTTCCAACAT GGCCGCCACT 180

GCCTCTCCGC AGCCACTCGC CACTGAGGAT GCCGATTCTG AGAATAGCAG CTTCTATTAC 240

TATGACTACC TGGATGAAGT GGCCTTCATG CTCTGCAGGA AGGATGCAGT GGTGTCCTTT 300

GGCAAAGTCT TCCTCCCAGT CTTCTATAGC CTGATTTTTG TGTTGGGCCT CAGCGGGAAC 360

CTCCTTCTTC TCATGGTCTT GCTCCGTTAC GTGCCTCGCA GGCGGATGGT TGAGATCTAT 420

CTGCTGAATC TGGCCATCTC CAACCTTCTG TTTCTGGTGA CACTGCCCTT CTGGGGCATC 480

TCCGTGGCCT GGCATTGGGT CTTCGGGAGT TTCTTGTGCA AGATGGTGAG CACTCTTTAT 540

ACTATTAACT TTTACAGTGG CATCTTTTTC ATTAGCTGCA TGAGCCTGGA CAAGTACCTG 600

GAGATCGTTC ATGCTCAGCC CTACCACAGG CTGAGGACCC GGGCCAAGAG CCTGCTCCTT 660

GCTACCATAG TATGGGCTGT GTCCCTGGCC GTCTCCATCC CTGATATGGT CTTTGTACAG 720

ACACATGAAA ATCCCAAGGG TGTGTGGAAC TGCCACGCAG ATTTCGGCGG GCATGGGACC 780

ATTTGGAAGC TCTTCCTCCG CTTCCAGCAG AACCTCCTAG GGTTTCTCCT TCCACTCCTT 840

GCCATGATCT TCTTCTACTC CCGTATTGGT TGTGTCTTGG TGAGGCTGAG GCCCGCAGGC 900

CAGGGCCGGG CTTTAAAAAT AGCTGCAGCC TTGGTGGTGG CCTTCTTCGT GCTATGGTTC 960

CCATACAATC TCACCTTGTT TCTGCATACG CTGTTGGACC TGCAAGTATT CGGGAACTGT 1020

GAGGTCAGCC AGCATCTAGA CTACGCACTC CAGGTAACAG AGAGCATCGC CTTCCTTCAC 1080

TGCTGCTTTT CCCCCATCCT GTATGCCTTC TCCAGTCACC GCTTCCGCCA GTACCTGAAG 1140

GCTTTCCTGG CTGCCGTGCT TGGATGGCAC CTGGCACCTG GCACTGCCCA GGCCTCATTA 1200

TCCAGCTGTT CTGAGAGCAG CATACTTACT GCCCAAGAGG AAATGACTGG CATGAATGAC 1260

CTTGGAGAGA GGCAGTCTGA GAACTACCCT AACAAGGAGG ATGTGGGGAA TAAATCAGCC 1320

TGAGTGACCA AATTTTGGTC TGGTGGGAAC AGATGGGAAC CAGCTCAATT GGGTGTCCAC 1380

TCAAAGTGCT CTCTCCAGGG GCCTCAGTGA CTGTGTTGCT AAACCCAGTG GTCAGTTCTC 1440

AGTTCTCAGC CATCAGCAGC ATTTGCTCGC CCCGCCTTCT TCCTCCACTT TCTTCACTTG 1500

CTTCCAGGAT ACCACGCTTT CTTTTCTGAA TTGCTACAAT CTTTCTTCCT TCCTTCCTTG 1560

CTTCCTTCCT TCCTTCCTTC CCTCTCTCCC TCCCTCCCTC CCTCGCTTCT TCCCTTCCTC 1620

CTTTCCTCCC TTCCTACTTT CCTTCCTTCC TTCTGACAGG GTCTTGCTCT ATTGCTCTGT 1680

CACCCAGGCT GGAATGCAGT GGCGAGATCT CCGCTCACTG TAGCCTCCTC CCCCTGGGTT 1740

GAAGCAATTC TCATGCCTCA GCCTCCCAAG TAGCCAGGAC TATAGGCACC TGCCACCATG 1800

CCTGGCTAAT TTTTGTATTT TTTTTCTTTC TTTCTTTCTT TTCTTTTTTT TTTTTTTTTG 1860

AGACGGAGTC TCACTCTTGT TGCCCAGGCT GGACAACAAT GGCGCGATCT CGGCTCACTG 1920

CAACCTCCAC CTCCCGGATT CAAGCGATTC TCCTGCCTCA GCCTCCTGAG TAGCTGGAAC 1980

TACATGCGCG TGCCACCACG CACAGCTAAT TTTTATAATT TTAGTAGAGA TGGGGTTTCA 2040

CTGCGTTGGC CAGGATGATC TCGATCTCTT GACCTTGGGA TCCACCCGCC TTGGCCTCCC 2100

AAAGTGCTGG GATTACAGGT GTGAGCCACC ATGCCTGGCC CTAATTTTTG TGTTTTTATT 2160

AGAAACAGAG TTTCACCATG TTGGCCAGGC TGGAGAATTG CTGTAATAGT TTTCCAACTG 2220

GCCCCTGTCC TTCCTCTCTC TTGCTCTCCT CCCATCTCAT CTGCACCTAG CAGCCAGAGT 2280

GATCCTGATA CTCTCGGCCT TTACTTCCGC CTCCCTCAGA GCAGCAGCCT GTCAAAACAC 2340

CAGATTACAA CAAATTTAGT TTAAAGGTCT CAATTAGCGT TATTGGCAAT TCTAGAATCA 2400

GGCAACAGAC TCATTGAATC AGGAACAGAT TCACTCCATA AAATACAGAG AGTGCTGCAA 2460

TGAGCTGGGT AGAAGAGGTT AGTTTTATAG ACAGGAAGGG GCTGTCAAAG GCAGAAAGAA 2520

ATGAAGAACA AAAAAAAAGA TTGATTTTTT TTTTTTTGAG ACAGGATCTC ACTCTGTCAT 2580

CCAGGCTGAA GTCCAATCCC ACAATCATGG CTCACTGCAG CCACCACCTC CTGAGCTCAA 2640

GTGATCCTCC CATCTAAGCC CCCAAGTAGC TAGGACTACA GGAGCACACC ACCACACCTG 2700

GCTAATTTTT GTATTTTTTG TGGAGACAGG GTCTCAGTAT GTTACCCAGG TTGGACTGGA 2760

AACCCTTGGC TCAAGCAATT TGCCTGCCTC AGCCTCCCAA AGTGCTGGGA TTACAGGCGT 2820

GAGCCACTGC ACAGGGCCAG ATTCATCATT TCAAAGTTAC TTTCTATATG CGGCCGGAAC 2880

AGGGTGGTTG ACATCAGTTT TCTTCAGGTT ACTTTTTAAT AATGATTAAA ACGGGGAACT 2940

TCATTATCAT GAGCATGGTT ACTGTCTGCA TTATTACGCC AACTGAAACT GTCATGTTTG 3000

GGAATTTGGC TGTTAACTCT GTCTCCAGGA GTCTCAAAGG TCAGATAACA ACTTAGTTTT 3060

GGTTTGAGGA CATGGAACTT TAATACGACA GATTCCATTT TGGTTTGGTC TGGTCAGCTG 3120

GGACCTAGTG CAGGAGGTTA GTCCAAAACA ATGGCCTTCC ATAGTTTTTA CTTAACAAGC 3180

CCAACTCCTT ACGGTAATCC TTTAAGGCCT ATGTGATCTG CCCTCACCCT GGCTACACTC 3240

TTTGCCCTTA TGTCCACCAG CCTCCAGTGC TCCAGACACA ACTGATCTCA AATACTCCTG 3300

ACACATCCCC CTGGGGATTC CTCTTCCTGG ATTGCTCTCC TCTCAGCTGT CTGCTTGGCT 3360

CACTCTCTCA CCTTCTGAGG TCTTAGCTCA GATACCACCT TTCACTCACC TGTCCAACCT 3420

ATTTAACACA AACTGGCCCA TCTCTGACGC TCCTGATCTT CCTGATGCTC TATTTTTAAA 3480

TTTTTTCAAT AGTGCTTATT TCTTTCAGAC ATTGTATATG TTTCTCCTAT TTGTGATGTT 540

CAGTGGCTAC TGTCCCCACC CACATTGTCC CAGGTGAATT CCACAAGGTA GGGATCTTGG 3600

TTAGGCTCAC TGCTGTACCC AACCCCCTAA CACAGGGCCT GGTGTGTAGG TTTTCAGAAA 3660

GTATCTGTAA AATGCATGGG TGGAGGAGGG AGCATTTTCC TTCTGGCACT GCTGGGGAAA 3720

AAGAACCTAA GGCCCTCCAC TCACCAGGGT TCCACATTCT CTGTAGTCCA GCTGGGAAAT 3780

GCTATTAAAA GGACCATTCT CGTAGCCTTG ATGGTGGACC CAGCATCTGG CAATCAGGAG 3840

GGCCTTGAAG TACTCTGCCT AGGGAATGTC CCAGGACCAT ATACAGTCTG CAGAAGGAGG 3900

CAGTGAACAC ACTTGGCCTA GGCCCCATCT CAGGAGCCTT CACATCTCCC TGGGACCTGC 3960

ACAATCAAGT CCAAAATCTT TGTCTGATGT CAAGGCTAGG GCTTTTGCAA ATAGGATCCC 4020

ATACATCTTC CAGCCCTCAT ACTCCTCCAC TCCCTTTTCA TTTCCTGAAC ATTCCAACTT 4080 CTATGCCTTT GCTCTTGTGG GCTCCCTCAT GTAATTAGGA TAATTTCCAG CCAGGTATTC 4140 CCTCACCCTT GTTTTACAAC TGAATCCCAC TTTCTCTGGG ACTCCACTGC TTGGTCACTC 4200 TGCCCTGTGC TTTGAGAGGA GGTTGGGTGG AGCATGGGAC ATGGGCCATT TACTGCCTTC 4260 ACATTTCCCT GGTCACGGTG ATTTTTTTAG GGGTGGGCAC ATGACCTAGG TAGAGCCAAT 4320 GAAGTGCAAT ATCACTAGAA CATGTGAGAA GAGAGGCATG AAACCGAAGC TGAGAGGGTT 4380 TGAGATCTGG AGCTACTCCT TCCTCCACCC AAACTTCAGA AGGTGAAGGA GATAGTGCAT 4440 GTGAGTGAGC AGATCCCGAG GGCACTGTTT GAGCCTCAGA ATCAAAGCAC TTCTGAAGCT 4500 AGTCCCAATC TTGGATTCGA CAGTTACAAG AACCAATAAA TTCCTTTCCT TGTGG

Seq ID NO: 129 Protein sequence Protein Accession ft: NP_001287.2 1 11 21 31 41 51

I I I 1 1 1 1 I 1

MAATASPQPL ATEDADSENS SFYYYDYLDE VAFMLCRKDA WSFGKVFLP VFYSLIFVLG 60 LSGNLLLLMV LLRYVPRRRM VEIYLLNLAI SNLLFLVTLP FWGISVAWHW VFGSFLCKMV 120 STLYTINFYS GIFFISCMSL DKYLEIVHAQ PYHRLRTRAK SLLLATI WA VSLAVSIPDM 180 VFVQTHENPK GVWNCHADFG GHGTIWKLFL RFQQNLLGFL LPLLAMIFFY SRIGCVLVRL 240 RPAGQGRALK IAAALWAFF VLWFPYNLTL FLHTLLDLQV FGNCEVSQHL DYALQVTESI 300 AFLHCCFSPI LYAFSSHRFR QYLKAFLAAV LGWHLAPGTA QASLSSCSES SILTAQEEMT 360 GMNDLGERQS ENYPNKEDVG NKSA

Seq ID NO: 130 DNA sequence Nucleic Acid Accession ft: NM_002774 Coding sequence: 246..980 1 11 21 31 51

I I I I"

AGGCGGACAA AGCCCGATTG TTCCTGGGCC CTTTCCCCAT CGCGCCTGGG CCTGCTCCCC 60 AGCCCGGGGC AGGGGCGGGG GCCAGTGTGG TGACACACGC TGTAGCTGTC TCCCCGGCTG 120 GCTGGCTCGC TCTCTCCTGG GGACACAGAG GTCGGCAGGC AGCACACAGA GGGACCTACG 180 GGCAGCTGTT CCTTCCCCCG ACTCAAGAAT CCCCGGAGGC CCGGAGGCCT GCAGCAGGAG 240 CGGCCATGAA GAAGCTGATG GTGGTGCTGA GTCTGATTGC TGCAGCCTGG GCAGAGGAGC 300 AGAATAAGTT GGTGCATGGC GGACCCTGCG ACAAGACATC TCACCCCTAC CAAGCTGCCC 360 TCTACACCTC GGGCCACTTG CTCTGTGGTG GGGTCCTTAT CCATCCACTG TGGGTCCTCA 420 CAGCTGCCCA CTGCAAAAAA CCGAATCTTC AGGTCTTCCT GGGGAAGCAT AACCTTCGGC 480 AAAGGGAGAG TTCCCAGGAG CAGAGTTCTG TTGTCCGGGC TGTGATCCAC CCTGACTATG 540 ATGCCGCCAG CCATGACCAG GACATCATGC TGTTGCGCCT GGCACGCCCA GCCAAACTCT 600 CTGAACTCAT CCAGCCCCTT CCCCTGGAGA GGGACTGCTC AGCCAACACC ACCAGCTGCC 660 ACATCCTGGG CTGGGGCAAG ACAGCAGATG GTGATTTCCC TGACACCATC CAGTGTGCAT 720 ACATCCACCT GGTGTCCCGT GAGGAGTGTG AGCATGCCTA CCCTGGCCAG ATCACCCAGA 780 ACATGTTGTG TGCTGGGGAT GAGAAGTACG GGAAGGATTC CTGCCAGGGT GATTCTGGGG 840 GTCCGCTGGT ATGTGGAGAC CACCTCCGAG GCCTTGTGTC ATGGGGTAAC ATCCCCTGTG 900 GATCAAAGGA GAAGCCAGGA GTCTACACCA ACGTCTGCAG ATACACGAAC TGGATCCAAA 960 AAACCATTCA GGCCAAGTGA CCCTGACATG TGACATCTAC CTCCCGACCT ACCACCCCAC 1020 TGGCTGGTTC CAGAACGTCT CTCACCTAGA CCTTGCCTCC CCTCCTCTCC TGCCCAGCTC 1080 TGACCCTGAT GCTTAATAAA CGCAGCGACG TGAGGGTCCT GATTCTCCCT GGTTTTACCC 1140 CAGCTCCATC CTTGCATCAC TGGGGAGGAC GTGATGAGTG AGGACTTGGG TCCTCGGTCT 1200 TACCCCCACC ACTAAGAGAA TACAGGAAAA TCCCTTCTAG GCATCTCCTC TCCCCAACCC 1260 TTCCACACGT TTGATTTCTT CCTGCAGAGG CCCAGCCACG TGTCTGGAAT CCCAGCTCCG 1320 CTGCTTACTG TCGGTGTCCC CTTGGGATGT ACCTTTCTTC ACTGCAGATT TCTCACCTGT 1380 AAGATGAAGA TAAGGATGAT ACAGTCTCCA TCAGGCAGTG GCTGTTGGAA AGATTTAAGA 1440 TTTCACACCT ATGACATACA TGGGATAGCA CCTGGGCCGC CATGCACTCA ATAAAGAATG 1500 TATTTT

Seq ID NO: 131 Protein sequence

Protein Accession ft: NP_002765

1 11 21 31 41 51

I I I I I I

MKKLMWLSL lAAAWAEEQN KLVHGGPCDK TSHPYQAALY TSGHLLCGGV LIHPLWVLTA 60 AHCKKPNLQV FLGKHNLRQR ESSQEQSSW RAVIHPDYDA ASHDQDIMLL RLARPAKLSE 120 LIQPLPLERD CSANTTSCHI LGWGKTADGD FPDTIQCAYI HLVSREECEH AYPGQITQNM 180 LCAGDEKYGK DSCQGDSGGP LVCGDHLRGL VSWGNIPCGS KEKPGVYTNV CRYTNWIQKT 240 IQAK

Seq ID NO : 132 DNA sequence Nucleic Acid Accession ft : AY03807 Coding sequence : 1 . . 1685 1 11 21 31 41 51

I I I

ATGAGCAATC AGTACCAGGA GGAGGGCTGC T 1CCGAGAGGC C 1CGAGTGCAA A 1AGTAAATCT 60 CCAACTTTGC TCTCCTCCTA CTGCATCGAC AGCATCCTGG GCCGGAGGAG CCCGTGCAAA 120 ATGCGGTTGC TGGGAGCCGC GCAGAGCTTG CCTGCTCCGC TGACCAGCCG CGCCGACCCG 180 GAAAAGGCCG TGCAAGGCTC CCCTAAGAGC AGCAGCGCCC CGTTCGAGGC CGAGCTGCAC 240 CTGCCGCCCA AGCTGCGGCG CCTGTACGGC CCGGGCGGGG GCCGCCTCCT TCAGGGTGCG 300 GCAGCGGCGG CGGCGGCGGC GGCGGCGGCG GCGGCAGCGG CCGCCACGGC CACGGCGGGT 360 CCACGCGGGG AGGCCCCTCC GCCGCCACCG CCAACCGCGC GGCCCGGGGA ACGGCCGGAC 420 GGCGCAGGGG CCGCCGCGGC AGCCGCGGCC GCGGCCGCCG CGGCCTGGGA CACGCTCAAG 480 ATCAGCCAGG CGCCGCAGGT GAGCATCAGC CGCAGCAAGT CGTACCGCGA GAACGGGGCG 540 CCCTTCGTGC CGCCGCCGCC CGCGCTGGAC GAGCTGGGCG GCCCGGGGGG CGTCACGCAC 600 CCGGAGGAGC GCCTCGGCGT GGCCGGCGGC CCGGGCAGCG CCCCGGCTGC GGGTGGTGGC 660 ACCGGCACCG AGGACGACGA GGAGGAGCTG CTGGAGGACG AAGAAGATGA GGACGAGGAA 720 GAGGAACTGC TGGAGGACGA CGAGGAGGAG CTGCTGGAGG ACGACGCCCG CGCGCTGCTC 780 AAGGAGCCCC GGCGCTGTCC TGTGGCCGCC ACTGGCGCCG TGGCCGCAGC AGCTGCCGCT 840 GCAGTGGCCA CAGAGGGCGG GGAGCTGTCA CCCAAGGAGG AGCTGCTGCT GCACCCGGAA 900 GACGCTGAGG GCAAGGACGG CGAGGACAGC GTGTGCCTCT CTGCGGGCAG CGACTCGGAG 960 GAGGGGCTGC TGAAACGCAA ACAGAGGCGC TACCGCACCA CGTTCACCAG GTACCAGCTG 1020 GAGGAACTGG AGCGGGCCTT CCAGAAGACG CACTACCCGG ACGTCTTCAC CAGGGAGGAA 1080 CTGGCCATGA GGCTGGACTT GACCGAGGCC CGAGTCCAGG TCTGGTTCCA GAACCGTCGG 1140 GCCAAGTGGC GCAAGCGGGA GAAGGCAGGC GCGCAGACCC ACCCCCCTGG GCTGCCCTTC 1200 CCGGGGCCGC TCTCCGCCAC CCACCCGCTC AGCCCCTACC TGGACGCCAG CCCCTTCCCT 1260 CCGCACCACC CGGCGCTCGA CTCCGCTTGG ACTGCCGCTG CCGCCGCCGC CGCCGCCGCC 1320 TTCCCGAGCC TACCTCCGCC TCCGGGCTCG GCCAGCCTGC CGCCCAGCGG GGCGCCGCTG 1380 GGCCTGAGCA CTTTCCTCGG AGCGGCAGTG TTCCGACACC CAGCTTTCAT CAGCCCGGCA 1440 TTCGGCAGGC TCTTTTCCAC AATGGCCCCC CTGACCAGCG CGTCGACCGC GGCCGCGCTC 1500 CTGAGACAGC CCACACCCGC CGTGGAGGGC GCAGTGGCAT CGGGCGCCCT GGCCGACCCG 1560 GCCACGGCGG CCGCAGACAG ACGCGCCTCT AGCATAGCCG CGCTGAGGCT CAAGGCCAAG 1620 GAGCACGCGG CGCAGCTCAC GCAGCTCAAC ATCCTGCCGG GCACCAGCAC GGGCAAGGAG 1680 GTGTGC

Seq ID NO: 133 Protein sequence Protein Accession ft: AAK93901.1

1 11 21

MSNQYQEEGC SERPECKSKS PTLLSSYCID SILGRRSPCK MRLLGAAQSL PAPLTSRADP 60

EKAVQGSPKS SSAPFEAELH LPPKLRRLYG PGGGRLLQGA AAAAAAAAAA AAAAATATAG 120

PRGEAPPPPP PTARPGERPD GAGAAAAAAA AAAAAWDTLK ISQAPQVSIS RSKSYRENGA 180

PFVPPPPALD ELGGPGGVTH PEERLGVAGG PGSAPAAGGG TGTEDDEEEL LEDEEDEDEE 240

EELLEDDEEE LLEDDARALL KEPRRCPVAA TGAVAAAAAA AVATEGGELS PKEELLLHPE 300

DAEGKDGEDS VCLSAGSDSE EGLLKRKQRR YRTTFTSYQL EELERAFQKT HYPDVFTREE 360

LAMRLDLTEA RVQVWFQNRR AKWRKREKAG AQTHPPGLPF PGPLSATHPL SPYLDASPFP 420

PHHPALDSAW TAAAAAAAAA FPSLPPPPGS ASLPPSGAPL GLSTFLGAAV FRHPAFISPA 480

FGRLFSTMAP LTSASTAAAL LRQPTPAVEG KVASGALADP ATAAADRRAS SIAALRLKAK 540

EHAAQLTQLN ILPGTSTGKE VC

Seq ID NO: 134 DNA sequence Nucleic Acid Accession ft: CAT cluster 1 11 21 31 41 51 _τ I_{τττττττττ} TITTTTTTAAA GICAGATCATC TICTCCAAATC ATCACTTCTA TCAAGCCTAT 60

TGCTTGAGCA GTGTTATAGC ACTCAGCCCT CAGGGCAAAG ATAAGTCTTC ACCATTGTCA 120 CACGTAGCAC ACACATATTC AGCCATATCA TGCTGAATGG GAATACAGGA CTTTGTAGAA 180

ACAGAACTGA TTCCTGCAGA ATATCCTGAG ATACTTATCA AGCTGTTAAA GGAGACATCA 240

GTCTTTTGTC TGTATTGCCC TTGACACCTC CTCAAGGAAA GTATCTAGAA ATTCTTTGTC 300

TTCTGAAGAA CCCTCAGACC TCTTAGGTCT AATGTAGGTT AAGTGCCCTG CAGATCTCCC 360

TAGAATAGAA AAGCACCTTG AAAACTGTAG TCTGACTTAA TAGACACAAA TATAATGAAA 420 GCACTAATTC ATAAGATCCT GTTATTTGAA GGAAAAAGCA GCAAAAGGCA CAAGCTTCAG 480

ATATTGGTCT TGCACAGGAA AAAGCTGGAA TTCTACC

Seq ID NO: 135 DNA sequence Nucleic Acid Accession ft: NM_0067 Coding sequence: 19..963 1 11 21

I I I

GCCGCGGGAG AGGAGGCCAT GGGCGCGCGC GGGGCGCTGC TGCTGGCGCT GCTGCTGGCT 60 CGGGCTGGAC TCAGGAAGCC GGAGTCGCAG GAGGCGGCGC CGTTATCAGG ACCATGCGGC 120 CGACGGGTCA TCACGTCGCG CATCGTGGGT GGAGAGGACG CCGAACTCGG GCGTTGGCCG 180 TGGCAGGGGA GCCTGCGCCT GTGGGATTCC CACGTATGCG GAGTGAGCCT GCTCAGCCAC 240 CGCTGGGCAC TCACGGCGGC GCACTGCTTT GAAACCTATA GTGACCTTAG TGATCCCTCC 300 GGGTGGATGG TCCAGTTTGG CCAGCTGACT TCCATGCCAT CCTTCTGGAG CCTGCAGGCC 360 TACTACACCC GTTACTTCGT ATCGAATATC TATCTGAGCC CTCGCTACCT GGGGAATTCA 420 CCCTATGACA TTGCCTTGGT GAAGCTGTCT GCACCTGTCA CCTACACTAA ACACATCCAG 480 CCCATCTGTC TCCAGGCCTC CACATTTGAG TTTGAGAACC GGACAGACTG CTGGGTGACT 540 GGCTGGGGGT ACATCAAAGA GGATGAGGCA CTGCCATCTC CCCACACCCT CCAGGAAGTT 600 CAGGTCGCCA TCATAAACAA CTCTATGTGC AACCACCTCT TCCTCAAGTA CAGTTTCCGC 660 AAGGACATCT TTGGAGACAT GGTTTGTGCT GGCAATGCCC AAGGCGGGAA GGATGCCTGC 720 TTCGGTGACT CAGGTGGACC CTTGGCCTGT AACAAGAATG GACTGTGGTA TCAGATTGGA 780 GTCGTGAGCT GGGGAGTGGG CTGTGGTCGG CCCAATCGGC CCGGTGTCTA CACCAATATC 840 AGCCACCACT TTGAGTGGAT CCAGAAGCTG ATGGCCCAGA GTGGCATGTC CCAGCCAGAC 900 CCCTCCTGGC CGCTACTCTT TTTCCCTCTT CTCTGGGCTC TCCCACTCCT GGGGCCGGTC 960 TGAGCCTACC TGAGCCCATG CAGCCTGGGG CCACTGCCAA GTCAGGCCCT GGTTCTCTTC 1020 TGTCTTGTTT GGTAATAAAC ACATTCCAGT TGATGCCTTG CAGGGCATTC TTCAAAA

Seq ID NO: 136 Protein sequence Protein Accession ft: NP_006790

1 11 21 51

I I I

MGARGALLLA LLLARAGLRK PESQEAAPLS GPCGRRVITS RIVGGEDAEL GRWPWQGSLR 60 LWDSHVCGVS LLSHRWALTA AHCFETYSDL SDPSGWMVQF GQLTSMPSFW SLQAYYTRYF 120 VSNIYLSPRY LGNSPYDIAL VKLSAPVTYT KHIQPICLQA STFEFENRTD CWVTGWGYIK 180 EDEALPSPHT LQEVQVAIIN NSMCNHLFLK YSFRKDIFGD MVCAGNAQGG KDACFGDSGG 240 PLACNKNGLW YQIGWSWGV GCGRPNRPGV YTNISHHFEW IQKLMAQSGM SQPDPSWPLL 300 FFPLLWALPL LGPV

Seq ID NO: 137 DNA sequence Nucleic Acid Accession ft: Eos sequence Coding sequence: 1..939

1 11 21 31 41 51

I I I I I I

ATGGGCGCGC GCGGGGCGCT GCTGCTGGCG CTGCTGCTGG CTCGGGCTGG ACTCAGGAAG 60 CCGGAGTCGC AGGAGGCGGC GCCCTTATCA GGACCATGCG GCCGACGGGT CATCACGTCG 120 CGCATCGTGG GTGGAGAGGA CGCCGAACTC GGGCGTTGGC CGTGGCAGGG GAGCCTGCGC 180 CTGTGGGATT CCCACGTATG CGGAGTGAGC CTGCTCAGCC ACCGCTGGGC ACTCACGGCG 240

GCGCACTGCT TTGAAACTGA CCTTAGTGAT CCCTCCGGGT GGATGGTCCA GTTTGGCCAG 300

CTGACTTCCA TGCCATCCTT CTGGAGCCTG CAGGCCTACT ACACCCGTTA CTTCGTATCG 360

AATATCTATC TGAGCCCTCG CTACCTGGGG AATTCACCCT ATGACATTGC CTTGGTGAAG 420

CTGTCTGCAC CTGTCACCTA CACTAAACAC ATCCAGCCCA TCTGTCTCCA GGCCTCCACA 480

TTTGAGTTTG AGAACCGGAC AGACTGCTGG GTGACTGGCT GGGGGTACAT CAAAGAGGAT 540

GAGGCACTGC CATCTCCCCA CACCCTCCAG GAAGTTCAGG TCGCCATCAT AAACAACTCT 600

ATGTGCAACC ACCTCTTCCT CAAGTACAGT TTCCGCAAGG ACATCTTTGG AGACATGGTT 660

TGTGCTGGCA ATGCCCAAGG CGGGAAGGAT GCCTGCTTCG GTGACTCAGG TGGACCCTTG 720

10 GCCTGTAACA AGAATGGACT GTGGTATCAG ATTGGAGTCG TGAGCTGGGG AGTGGGCTGT 780

GGTCGGCCCA ATCGGCCCGG TGTCTACACC AATATCAGCC ACCACTTTGA GTGGATCCAG 840

AAGCTGATGG CCCAGAGTGG CATGTCCCAG CCAGACCCCT CCTGGCCACT ACTCTTTTTC 900 CCTCTTCTCT GGGCTCTCCC ACTCCTGGGG CCGGTCTGA

15 Seq ID NO: 138 Protein sequence

Protein Accession ft : Eos sequence

1 11 21 31 41 51

I I I I I I

MGARGALLLA LLLARAGLRK PESQEAAPLS GPCGRRVITS RIVGGEDAEL GRWPWQGSLR 60

20 LWDSHVCGVS LLSHRWALTA AHCFETDLSD PSGWMVQFGQ LTSMPSFWSL QAYYTRYFVS 120

NIYLSPRYLG NSPYDIALVK LSAPVTYTKH IQPICLQAST FEFENRTDCW VTGWGYIKED 180

EALPSPHTLQ EVQVAIINNS MCNHLFLKYS FRKDIFGDMV CAGNAQGGKD ACFGDSGGPL 240

ACNKNGLWYQ IGWSWGVGC GRPNRPGVYT NISHHFEWIQ KLMAQSGMSQ PDPSWPLLFF 300 PLLWALPLLG PV

25

Seq ID NO: 139 DNA sequence Nucleic Acid Accession ft: NM_014344 Coding sequence: 131..1444 „. 1 11 21 31 41 51

30 i i i i i i

GCGGCCGCGA TGGGGCCGAA GCGCCCGAAG CCCCGGAGCC CACAAACTGC CGGGCCCGCC 60

TCGCCGCCGG GACCCGGGTG CCTGGGCTCG GCTTGAAGCG GCGGCGGCGC ACCGGCACAG 120

CCGCGGGAGC ATGGGCAGGA GGATGCGGGG CGCCGCCGCC ACCGCGGGGC TCTGGCTGCT 180

GGCGCTGGGC TCGCTGCTGG CGCTGTGGGG AGGGCTCCTG CCGCCGCGGA CCGAGCTGCC 240

35 CGCCTCCCGG CCGCCCGAAG ACCGACTCCC ACGGCGCCCG GCCCGGAGCG GCGGCCCCGC 300

GCCCGCGCCT CGCTTCCCTC TGCCCCCGCC CCTGGCGTGG GACGCCCGCG GCGGCTCCCT 360

GAAAACTTTC CGGGCGCTGC TCACCCTGGC GGCCGGCGCG GACGGCCCGC CCCGGCAGTC 420

CCGGAGCGAG CCCAGGTGGC ACGTGTCAGC CAGGCAGCCC CGGCCGGAGG AGAGCGCCGC 80

GGTGCACGGG GGCGTCTTCT GGAGCCGCGG CCTGGAGGAG CAGGTGCCCC CGGGCTTTTC 540

40 GGAGGCCCAG GCGGCGGCGT GGCTGGAGGC GGCTCGCGGC GCCCGGATGG TGGCCCTGGA 600

GCGCGGGGGT TGCGGGCGCA GCTCCAACCG ACTGGCCCGT TTTGCCGACG GCACCCGCGC 660

CTGCGTGCGC TACGGCATCA ACCCGGAGCA GATTCAGGGC GAGGCCCTGT CTTACTATCT 720

GGCGCGCCTG CTGGGCCTCC AGCGCCACGT GGCGCCGCTG GCACTGGCTC GGGTGGAGGC 780

TCGGGGCGCG CAGTGGGCGC AGGTGCAGGA GGAGCTGCGC GCTGCGCACT GGACCGAGGG 840

45 CAGCGTGGTG AGCCTGACAC GCTGGCTGCC CAACCTCACG GACGTGGTGG TGCCCGCGCC 900

CTGGCGCTCG GAGGACGGCC GTCTGCGCCC CCTCCGGGAT GCCGGGGGTG AGCTGGCCAA 960

CCTCAGCCAG GCGGAGCTGG TGGACCTAGT ACAATGGACC GACTTAATCC TTTTCGACTA 1020

CCTGACGGCC AACTTCGACC GGCTCGTAAG CAACCTCTTC AGCCTGCAGT GGGACCCGCG 1080

CGTCATGCAG CGTGCCACCA GCAACCTGCA CCGCGGTCCG GGCGGGGCGC TGGTCTTTCT 1140

50 GGACAATGAG GCGGGCTTGG TGCACGGCTA CCGGGTAGCA GGCATGTGGG ACAAGTATAA 1200

CGAGCCGCTG TTGCAGTCAG TGTGCGTGTT CCGCGAGCGG ACCGCGCGGC GCGTCCTGGA 1260

GCTGCACCGC GGACAGGACG CCGCGGCCCG GCTGCTGCGC CTCTACCGGC GCCACGAGCC 1320

TCGCTTCCCC GAGCTGGCCG CCCTTGCAGA CCCCCACGCT CAGCTGCTAC AGCGCCGCCT 1380

CGACTTCCTC GCCAAGCACA TTTTGCACTG TAAGGCCAAG TACGGCCGCC GGTCTGGGAC 1440

55 TTAGTGTCAC CGGGAGGAAA AGAGAGAGAT CTGGGGCTGG GGTATGGATG ATGGGGGGAA 1500

GGGCGGTCGC CTCTGCCACT GTCAGGGACC AGCCGGCCAA CGCCCACCCG CAAAGGTGTC 1560

TAAAAACTTC AGCTTTTCAC CCACCTGCCC CTTTCTTTCA ATCCCACGCT GTTTCCTTTC 1620

AAAGTTCTGG GAGGACGAAC TCACCGAGGC GAGAAGTGTA ACATTCTCTC CACCCAGCTT 1680

ATAAAAGGAT TCTTTACTGT GCCAGCACGG GGATTGGATC CGAAGAAACT GGCTACTGGG 1740

60 GTTTGGCCCC CGAGTGGCCG TCCCTGTGGG AGATGCACCC CATTCTTGGG CCCCCCTCAT 1800

TCCCTTTCCG AAAAAGGAAA ACTTGCGTTT GAGCCGTTGA GCTAATTCTG CAATTTTCTA 1860

CCAAACAGAG CGCTGGTGGC CCCGGAGCAG GGCTGTGACA TTGGCTGGTG GAGCCCCTTC 1920

CTGTGTTCTC CCTTTGTTCC AGCGCCGCGA TGGTGAGATC ACTGTTCCAA GCAGGGGGAC 1980

GGCTCGCGAT AGGACAAAGA GAGCAGGACC TCCAGACTCT GGGGAGCCCT GCAGACCTTG 2040

65 ACAATTTGCC TGACTCATTC CTGACCTCTT GTCATTTTGG CCTGAAGGCT ACAAATTCAG 2100

GGTCAGCTGT ATGCACTAAG TCAAATAATG AATTTCTTCC TCCCTCTCGC AACCGACCAA 2160

AATTTTGACA ACGATGATGT TCACCAGAAG GAAAAAAAAA TCAGTTTTAT GCACTTTATT 2220

TTGTTTTGAT TTTCATTTTT TATTAAGAAA AAATTTTATT TTACAGAATT TACCTTCTCT 2280

GTATATATGT GCATAAAGTG TGGTGTAAAT ATACTAAACA AACTTATATT TCAATAAAAG 2340

70 GGAGTTTAAA ATTTAAAAAA AAAAAAA

Seq ID NO: 140 Protein sequence Protein Accession ft: NP_055159 __ 1 11 21 31 41 SI

75 i I i i i i

MGRRMRGAAA TAGLWLLALG SLLALWGGLL PPRTELPASR PPEDRLPRRP ARSGGPAPAP 60

RFPLPPPLAW DARGGSLKTF RALLTLAAGA DGPPRQSRSE PRWHVSARQP RPEESAAVHG 120

GVFWSRGLEE QVPPGPSEAQ AAAWLEAARG ARMVALERGG CGRSSNRLAR FADGTRACVR 180

YGINPEQIQG EALSYYLARL LGLQRHVPPL ALARVEARGA QWAQVQEELR AAHWTEGSW 240

80 SLTRWLPNLT D VPAPWRS EDGRLRPLRD AGGELANLSQ AELVDLVQWT DLILFDYLTA 300

NFDRLVSNLF SLQWDPRVMQ RATSNLHRGP GGALVFLDNE AGLVHGYRVA GMWDKYNEPL 360

LQSVCVFRER TARRVLELHR GQDAAARLLR LYRRHEPRFP ELAALADPHA QLLQRRLDFL 420 AKHILHCKAK YGRRSGT

85 Seq ID NO: 141 DNA sequence Nucleic Acid Accession ft: Eos sequence

Coding sequence : 11..574

1 11 21 31 41 51

I I I I I I

GTCCGCCAAG ATGCCTGGCC CAGTCCCTCT GCTGTCTGCA GCCCAGCCTT CACCCTCTTG 60 CATGGGGAAA TCGTCTACAG ACTTCTGCCC ATGGCTGTAT GTACGCACGG ACAGAGCTAG 120 CAATGACCCT GCTGGCAGGT ATGATAGGAA GCCTCTTCTG TCACAGGATT CATTCCCAGA 180 CAATGACCCC AAATGCCTGT CCCTGCTCCC CCCACCCCCC AACATCAAAA TAGCCGAGAA 240 AAATGCCCTT CTCGGAGCCA AATGTGTGGT GATGCCTTAC AATCAGAAAT TCCTACAGTG 300 GCCTGAGGCT TCCACCACTA AACGCAAAGC TGTAGATACC TATTGCTTGG ATTATAAGCC 360 TTCCAAGGGA AGAAGGTGGG CTGCAAGAGC ACCAAGCACC AGAATCACAT ATGGGACTAT 420 CACCAAAGAG AGAGACTACT GCGCGGAAGA CCAGACTATC GAGAGCTGGA GAGAAGAAGG 480 TTTCCCAGTG GGCTTGAAGC TTGCTGTGCT TGGTATTTTC ATCATTGTGG TGTTTGTCTA 540 CCTGACTGTG GAAAATAAGT CGCTGTTTGG TTAAGTAATT TAGG

Seq ID NO: 142 Protein sequence Protein Accession ft: Eos sequence 1 11 21 31 41 51

I I I I I I

MPAPVPLLSA AQPSPSCMGK SSTDFCPWLY VRTDRASNDP AGRYDRKPLL SQDSFPDNDP 60 KCLSLLPPPP NIKIAEKNAL LGAKCWMPY NQKFLQWPEA STTKRKAVDT YCLDYKPSKG 120 RRWAARAPST RITYGTITKE RDYCAEDQTI ESWREEGEPV GLKLAVLGIF IIWFVYLTV 180 ENKSLFG

Seq ID NO: 143 DNA sequence Nucleic Acid Accession ft: XM_0501 84.6 Coding sequence: 39..365 1 11 21 31

G IATTCTACCA TICAGAAAAGA GIGCCAAACTT CTATCATCAT GGTGGATGTG AAGTGTCTGA 60 GTGACTGTAA ATTGCAGAAC CAACTTGAGA AGCTTGGATT TTCACCTGGC CCAATACTAC 120 CTTCCACCAG AAAGTTGTAT GAAAAAAAGT TAGTACAGTT GTTGGTCTCA CCTCCCTGTG 180 CACCACCTGT GATGAATGGA CCCAGAGAGC TGGATGGAGC GCAGGACAGT GATGACAGCG 240 AAGGTGGGCT GCAAGAGCAC CAAGCACCAG AATCACATAT GGGACTATCA CCAAAGAGAG 300 AGACTACTGC GCGGAAGACC AGACTATCGA GAGCTGGAGA GAAGAAGGTT TCCCAGTGGG 360 CTTGAAGCTT GCTGTGCTTG GTATTTTCAT CATTGTGGTG TTTGTCTACC TGACTGTGGA 420 AAATAAGTCG CTGTTTGGTT AAGTAATTTA GGAGCAAAGC AATGCTCCAA GCGAGGCCTC 480 CTGCTTCAGG AAAGAACCAA AACACTACCC TGAAGGGCCA GCCTAGCCTG CAGCCCTCCC 540 TTGCAGGGAG CCTTCCCTTG CACTGTGCTG CTCTCACAGA TCGGTGTCTG GGCTCAGCCA 600 GGTGGAAGGA ACCTGCCTAA CCAGGCACCT GTGTTAAGAG CATGATGGTT AGGAAATCCC 660 CCAAGTCATG TCAACTCTCA TTAAAGGTGC TTCCATATTT GAGCAGGCGT CAAAC

Seq ID NO: 144 Protein sequence Protein Accession ft: XP_050184.1 1 11 21 31 41 51

I I I I I I

MVDVKCLSDC KLQNQLEKLG FSPGPILPST RKLYEKKLVQ LLVSPPCAPP VMNGPRELDG AQDSDDSEGG LQEHQAPESH MGLSPKRETT ARKTRLSRAG EKKVSQWA

Seq ID NO: 145 DNA sequence Nucleic Acid Accession ft: NM_0022 Coding sequence: 74..3229 1 11 21 51

I I I

AGGTGAACAG GTCCTCACGC CCAGCTCCGC CCCCTCACGC GCTCTCGCCG GGACCCCGCT 60 TCCGCTGGCA GCCATGGGCC CCGGCCCCAG CCGCGCGCCC CGCGCCCCAC GCCTGATGCT 120 CTGTGCGCTC GCCTTGATGG TGGCGGCCGG CGGCTGCGTC GTCTCCGCCT TCAACCTGGA 180 TACCCGATTC CTGGTAGTGA AGGAGGCCGG GAACCCGGGC AGCCTCTTCG GCTACTCGGT 240 CGCCCTCCAT CGGCAGACAG AGCGGCAGCA GCGCTACCTG CTCCTGGCTG GTGCCCCCCG 300 GGAGCTCGCT GTGCCCGATG GCTACACCAA CCGGACTGGT GCTGTGTACC TGTGCCCACT 360 CACTGCCCAC AAGGATGACT GTGAGCGGAT GAACATCACA GTGAAAAATG ACCCTGGCCA 420 TCACATTATT GAGGACATGT GGCTTGGAGT GACTGTGGCC AGCCAGGGCC CTGCAGGCAG 480 AGTTCTGGTC TGTGCCCACC GCTACACCCA GGTGCTGTGG TCAGGGTCAG AAGACCAGCG 540 GCGCATGGTG GGCAAGTGCT ACGTGCGAGG CAATGACCTA GAGCTGGACT CCAGTGATGA 600 CTGGCAGACC TACCACAACG AGATGTGCAA TAGCAACACA GACTACCTGG AGACGGGCAT 660 GTGCCAGCTG GGCACCAGCG GTGGCTTCAC CCAGAACACT GTGTACTTCG GCGCCCCCGG 720 TGCCTACAAC TGGAAAGGAA ACAGCTACAT GATTCAGCGC AAGGAGTGGG ACTTATCTGA 780 GTATAGTTAC AAGGACCCAG AGGACCAAGG AAACCTCTAT ATTGGGTACA CGATGCAGGT 840 AGGCAGCTTC ATCCTGCACC CCAAAAACAT CACCATTGTG ACAGGTGCCC CACGGCACCG 900 ACATATGGGC GCGGTGTTCT TGCTGAGCCA GGAGGCAGGC GGAGACCTGC GGAGGAGGCA 960 GGTGCTGGAG GGCTCGCAGG TGGGCGCCTA TTTTGGCAGC GCAATTGCCC TGGCAGACCT 1020 GAACAATGAT GGGTGGCAGG ACCTCCTGGT GGGCGCCCCC TACTACTTCG AGAGGAAAGA 1080 GGAAGTAGGG GGTGCCATCT ATGTCTTCAT GAACCAGGCG GGAACCTCCT TCCCTGCTCA 1140 CCCCTCACTC CTTCTTCATG GCCCCAGTGG CTCTGCCTTT GGTTTATCTG TGGCCAGCAT 1200 TGGTGACATC AACCAGGATG GATTTCAGGA TATTGCTGTG GGAGCTCCGT TTGAAGGCTT 1260 GGGCAAAGTG TACATCTATC ACAGTAGCTC TAAGGGGCTC CTTAGACAGC CCCAGCAGGT 1320 AATCCATGGA GAGAAGCTGG GACTGCCTGG GTTGGCCACC TTCGGCTATT CCCTCAGTGG 1380 GCAGATGGAT GTGGATGAGA ACTTCTACCC AGACCTTCTA GTGGGAAGCC TGTCAGACCA 1440 CATTGTGCTG CTGCGGGCCC GGCCAGTCAT CAACATCGTC CACAAGACCT TGGTGCCCAG 1500 GCCAGCTGTG CTGGACCCTG CACTTTGCAC GGCCACCTCT TGTGTGCAAG TGGAGCTGTG 1560 CTTTGCTTAC AACCAGAGTG CCGGGAACCC CAACTACAGG CGAAACATCA CCCTGGCCTA 1620 CACTCTGGAG GCTGACAGGG ACCGCCGGCC GCCCCGGCTC CGCTTTGCCG GCAGTGAGTC 1680 CGCTGTCTTC CACGGCTTCT TCTCCATGCC CGAGATGCGC TGCCAGAAGC TGGAGCTGCT 1740 CCTGATGGAC AACCTCCGTG ACAAACTCCG CCCCATCATC ATCTCCATGA ACTACTCTTT 1800 ACCTTTGCGG ATGCCCGATC GCCCCCGGCT GGGGCTGCGG TCCCTGGACG CCTACCCGAT 1860 CCTCAACCAG GCACAGGCTC TGGAGAACCA CACTGAGGTC CAGTTCCAGA AGGAGTGCGG 1920

GCCTGACAAC AAGTGTGAGA GCAACTTGCA GATGCGGGCA GCCTTCGTGT CAGAGCAGCA 1980

GCAGAAGCTG AGCAGGCTCC AGTACAGCAG AGACGTCCGG AAATTGCTCC TGAGCATCAA 2040

CGTGACGAAC ACCCGGACCT CGGAGCGCTC CGGGGAGGAC GCCCACGAGG CGCTGCTCAC 2100

CCTGGTGGTG CCTCCCGCCC TGCTGCTGTC CTCAGTGCGC CCCCCCGGGG CCTGCCAAGC 2160

TAATGAGACC ATCTTTTGCG AGCTGGGGAA CCCCTTCAAA CGGAACCAGA GGATGGAGCT 2220

GCTCATCGCC TTTGAGGTCA TCGGGGTGAC CCTGCACACA AGGGACCTTC AGGTGCAGCT 2280

GCAGCTCTCC ACGTCGAGTC ACCAGGACAA CCTGTGGCCC ATGATCCTCA CTCTGCTGGT 2340

GGACTATACA CTCCAGACCT CGCTTAGCAT GGTAAATCAC CGGCTACAAA GCTTCTTTGG 2400

GGGGACAGTG ATGGGTGAGT CTGGCATGAA AACTGTGGAG GATGTAGGAA GCCCCCTCAA 2460

GTATGAATTC CAGGTGGGCC CAATGGGGGA GGGGCTGGTG GGCCTGGGGA CCCTGGTCCT 2520

AGGTCTGGAG TGGCCCTACG AAGTCAGCAA TGGCAAGTGG CTGCTGTATC CCACGGAGAT 2580

CACCGTCCAT GGCAATGGGT CCTGGCCCTG CCGACCACCT GGAGACCTTA TCAACCCTCT 2640

CAACCTCACT CTTTCTGACC CTGGGGACAG GCCATCATCC CCACAGCGCA GGCGCCGACA 2700

GCTGGATCCA GGGGGAGGCC AGGGCCCCCC ACCTGTCACT CTGGCTGCTG CCAAAAAAGC 2760

CAAGTCTGAG ACTGTGCTGA CCTGTGCCAC AGGGCGTGCC CACTGTGTGT GGCTAGAGTG 2820

CCCCATCCCT GATGCCCCCG TTGTCACCAA CGTGACTGTG AAGGCACGAG TGTGGAACAG 2880

CACCTTCATC GAGGATTACA GAGACTTTGA CCGAGTCCGG GTAAATGGCT GGGCTACCCT 2940

ATTCCTCCGA ACCAGCATCC CCACCATCAA CATGGAGAAC AAGACCACGT GGTTCTCTGT 3000

GGACATTGAC TCGGAGCTGG TGGAGGAGCT GCCGGCCGAA ATCGAGCTGT GGCTGGTGCT 3060

GGTGGCCGTG GGTGCAGGGC TGCTGCTGCT GGGGCTGATC ATCCTCCTGC TGTGGAAGTG 3120

CGGCTTCTTC AAGCGAGCCC GCACTCGCGC CCTGTATGAA GCTAAGAGGC AGAAGGCGGA 3180

GATGAAGAGC CAGCCGTCAG AGACAGAGAG GCTGACCGAC GACTACTGAG GGGGCAGCCC 3240

CCCGCCCCCG GCCCACCTGG TGTGACTTCT TTAAGCGGAC CCGCTATTAT CAGATCATGC 3300

CCAAGTACCA CGCAGTGCGG ATCCGGGAGG AGGAGCGCTA CCCACCTCCA GGGAGCACCC 3360

TGCCCACCAA GAAGCACTGG GTGACCAGCT GGCAGACTCG GGACCAATAC TACTGACGTC 3420

CTCCCTGATC CCACCCCCTC CTCCCCCAGT GTCCCCTTTC TTCCTATTTA TCATAAGTTA 3480

TGCCTCTGAC AGTCCACAGG GGCCACCACC TTTGGCTGGT AGCAGCAGGC TCAGGCACAT 3540

ACACCTCGTC AAGAGCATGC ACATGCTGTC TGGCCCTGGG GATCTTCCCA CAGGAGGGCC 3600

AGCGCTGTGG ACCTTACAAC GCCGAGTGCA CTGCATTCCT GTGCCCTAGA TGCACGTGGG 3660

GCCCACTGCT CGTGGACTGT GCTGGTGCAT CACGGATGGT GCATGGGCTC GCCGTGTCTC 3720

AGCCTCTGCC AGCGCCAGCG CCAAAACAAG CCAAAGAGCC TCCCACCAGA GCCGGGAGGA 3780

AAAGGCCCCT GCAATGTGGT GACACCTCCC CTTTCACACC TGGATCCATC TTGAGAGCCA 3840

CAGTCACTGG ATTGACTTTG CTGTCAAAAC TACTGACAGG GAGCAGCCCC CGGGCCGCTG 3900

GCTGGTGGGC CCCCAATTGA CACCCATGCC AGAGAGGTGG GGATCCTGCC TAAGGTTGTC 3960

TACGGGGGCA CTTGGAGGAC CTGGCGTGCT CAGACCCAAC AGCAAAGGAA CTAGAAAGAA 4020

GGACCCAGAA GGCTTGCTTT CCTGCATCTC TGTGAAGCCT CTCTCCTTGG CCACAGACTG 4080

AACTCGCAGG GAGTGCAGCA GGAAGGAACA AAGACAGGCA AACGGCAACG TAGCCTGGGC 4140

TCACTGTGCT GGGGCATGGC GGGATCCTCC ACAGAGAGGA GGGGACCAAT TCTGGACAGA 4200

CAGATGTTGG GAGGATACAG AGGAGATGCC ACTTCTCACT CACCACTACC AGCCAGCCTC 4260

CAGAAGGCCC CAGAGAGACC CTGCAAGACC ACGGAGGGAG CCGACACTTG AATGTAGTAA 4320

TAGGCAGGGG GCCCTGCCAC CCCATCCAGC CAGACCCCAG CTGAACCATG CGTCAGGGGC 4380

CTAGAGGTGG AGTTCTTAGC TATCCTTGGC TTTCTGTGCC AGCCTGGCTC TGCCCCTCCC 4440

CCATGGGCTG TGTCCTAAGG CCCATTTGAG AAGCTGAGGC TAGTTCCAAA AACCTCTCCT 4500

GACCCCTGCC TGTTGGCAGC CCACTCCCCA GCCCCAGCCC CTTCCATGGT ACTGTAGCAG 4560

GGGAATTCCC TCCCCCTCCT TGTGCCTTCT TTGTATATAG GCTTCTCACC GCGACCAATA 4620 AACAGCTCCC AGTTTGT

Seq ID NO: 146 Protein sequence

Protein Accession ft: NP_002195.1

1 11 21 31 41 51

M IGPGPSRAPR AIPRLMLCALA LIMVAAGGCW SIAFNLDTRFL WIKEAGNPGS LIFGYSVALHR 60

QTERQQRYLL LAGAPRELAV PDGYTNRTGA VYLCPLTAHK DDCERMNITV KNDPGHHIIE 120

DMWLGVTVAS QGPAGRVLVC AHRYTQVLWS GSEDQRRMVG KCYVRGNDLE LDSSDDWQTY 180

HNEMCNSNTD YLETGMCQLG TSGGFTQNTV YFGAPGAYNW KGNSYMIQRK EWDLSEYSYK 240

DPEDQGNLYI GYTMQVGSFI LHPKNITIVT GAPRHRHMGA VFLLSQEAGG DLRRRQVLEG 300

SQVGAYFGSA IALADLNNDG WQDLLVGAPY YFERKEEVGG AIYVFMNQAG TSFPAHPSLL 360

LHGPSGSAFG LSVASIGDIN QDGFQDIAVG APFEGLGKVY IYHSSSKGLL RQPQQVIHGE 420

KLGLPGLATF GYSLSGQMDV DENFYPDLLV GSLSDHIVLL RARPVINIVH KTLVPRPAVL 480

DPALCTATSC VQVELCFAYN QSAGNPNYRR NITLAYTLEA DRDRRPPRLR FAGSESAVFH 540

GFFSMPEMRC QKLELLLMDN LRDKLRPIII SMNYSLPLRM PDRPRLGLRS LDAYPILNQA 600

QALENHTEVQ FQKECGPDNK CESNLQMRAA FVSEQQQKLS RLQYSRDVRK LLLSINVTNT 660

RTSERSGEDA HEALLTL P PALLLSSVRP PGACQANETI FCELGNPFKR NQRMELLIAF 720

EVIGVTLHTR DLQVQLQLST SSHQDNLWPM ILTLLVDYTL QTSLSMVNHR LQSFFGGTVM 780

GESGMKTVED VGSPLKYEFQ VGPMGEGLVG LGTLVLGLEW PYEVSNGKWL LYPTEITVHG 840

NGSWPCRPPG DLINPLNLTL SDPGDRPSSP QRRRRQLDPG GGQGPPPVTL AAAKKAKSET 900

VLTCATGRAH CVWLECPIPD APWTNVTVK ARVWNSTFIE DYRDFDRVRV NGWATLFLRT 960

SIPTINMENK TTWFSVDIDS ELVEELPAEI ELWLVLVAVG AGLLLLGLII LLLWKCGFFK 1020 RARTRALYEA KRQKAEMKSQ PSETERLTDD Y

Seq ID NO: 147 DNA sequence

Nucleic Acid Accession ft: NM_005501.1

Coding sequence: 74..3274

1 11 21 31 41 51

A IGGTGAACAG GITCCTCACGC CICAGCTCCGC CICCCTCACGC GICTCTCGCCG GIGACCCCGCT 60

TCCGCTGGCA GCCATGGGCC CCGGCCCCAG CCGCGCGCCC CGCGCCCCAC GCCTGATGCT 120

CTGTGCGCTC GCCTTGATGG TGGCGGCCGG CGGCTGCGTC GTCTCCGCCT TCAACCTGGA 180

TACCCGATTC CTGGTAGTGA AGGAGGCCGG GAACCCGGGC AGCCTCTTCG GCTACTCGGT 240

CGCCCTCCAT CGGCAGACAG AGCGGCAGCA GCGCTACCTG CTCCTGGCTG GTGCCCCCCG 300

GGAGCTCGCT GTGCCCGATG GCTACACCAA CCGGACTGGT GCTGTGTACC TGTGCCCACT 360

CACTGCCCAC AAGGATGACT GTGAGCGGAT GAACATCACA GTGAAAAATG ACCCTGGCCA 420

TCACATTATT GAGGACATGT GGCTTGGAGT GACTGTGGCC AGCCAGGGCC CTGCAGGCAG 480

AGTTCTGGTC TGTGCCCACC GCTACACCCA GGTGCTGTGG TCAGGGTCAG AAGACCAGCG 540 GCGCATGGTG GGCAAGTGCT ACGTGCGAGG CAATGACCTA GAGCTGGACT CCAGTGATGA 600

CTGGCAGACC TACCACAACG AGATGTGCAA TAGCAACACA GACTACCTGG AGACGGGCAT 660

GTGCCAGCTG GGCACCAGCG GTGGCTTCAC CCAGAACACT GTGTACTTCG GCGCCCCCGG 720

TGCCTACAAC TGGAAAGGAA ACAGCTACAT GATTCAGCGC AAGGAGTGGG ACTTATCTGA 780 GTATAGTTAC AAGGACCCAG AGGACCAAGG AAACCTCTAT ATTGGGTACA CGATGCAGGT 840

AGGCAGCTTC ATCCTGCACC CCAAAAACAT CACCATTGTG ACAGGTGCCC CACGGCACCG 900

ACATATGGGC GCGGTGTTCT TGCTGAGCCA GGAGGCAGGC GGAGACCTGC GGAGGAGGCA 960

GGTGCTGGAG GGCTCGCAGG TGGGCGCCTA TTTTGGCAGC GCAATTGCCC TGGCAGACCT 1020

GAACAATGAT GGGTGGCAGG ACCTCCTGGT GGGCGCCCCC TACTACTTCG AGAGGAAAGA 1080 GGAAGTAGGG GGTGCCATCT ATGTCTTCAT GAACCAGGCG GGAACCTCCT TCCCTGCTCA 1140

CCCCTCACTC CTTCTTCATG GCCCCAGTGG CTCTGCCTTT GGTTTATCTG TGGCCAGCAT 1200

TGGTGACATC AACCAGGATG GATTTCAGGA TATTGCTGTG GGAGCTCCGT TTGAAGGCTT 1260

GGGCAAAGTG TACATCTATC ACAGTAGCTC TAAGGGGCTC CTTAGACAGC CCCAGCAGGT 1320

AATCCATGGA GAGAAGCTGG GACTGCCTGG GTTGGCCACC TTCGGCTATT CCCTCAGTGG 1380 GCAGATGGAT GTGGATGAGA ACTTCTACCC AGACCTTCTA GTGGGAAGCC TGTCAGACCA 1440

CATTGTGCTG CTGCGGGCCC GGCCAGTCAT CAACATCGTC CACAAGACCT TGGTGCCCAG 1500

GCCAGCTGTG CTGGACCCTG CACTTTGCAC GGCCACCTCT TGTGTGCAAG TGGAGCTGTG 1560

CTTTGCTTAC AACCAGAGTG CCGGGAACCC CAACTACAGG CGAAACATCA CCCTGGCCTA 1620

CACTCTGGAG GCTGACAGGG ACCGCCGGCC GCCCCGGCTC CGCTTTGCCG GCAGTGAGTC 1680 CGCTGTCTTC CACGGCTTCT TCTCCATGCC CGAGATGCGC TGCCAGAAGC TGGAGCTGCT 1740

CCTGATGGAC AACCTCCGTG ACAAACTCCG CCCCATCATC ATCTCCATGA ACTACTCTTT 1800

ACCTTTGCGG ATGCCCGATC GCCCCCGGCT GGGGCTGCGG TCCCTGGACG CCTACCCGAT 1860

CCTCAACCAG GCACAGGCTC TGGAGAACCA CACTGAGGTC CAGTTCCAGA AGGAGTGCGG 1920 GCCTGACAAC AAGTGTGAGA GCAACTTGCA GATGCGGGCA GCCTTCGTGT CAGAGCAGCA 1980 GCAGAAGCTG AGCAGGCTCC AGTACAGCAG AGACGTCCGG AAATTGCTCC TGAGCATCAA 2040

CGTGACGAAC ACCCGGACCT CGGAGCGCTC CGGGGAGGAC GCCCACGAGG CGCTGCTCAC 2100

CCTGGTGGTG CCTCCCGCCC TGCTGCTGTC CTCAGTGCGC CCCCCCGGGG CCTGCCAAGC 2160

TAATGAGACC ATCTTTTGCG AGCTGGGGAA CCCCTTCAAA CGGAACCAGA GGATGGAGCT 2220

GCTCATCGCC TTTGAGGTCA TCGGGGTGAC CCTGCACACA AGGGACCTTC AGGTGCAGCT 2280 GCAGCTCTCC ACGTCGAGTC ACCAGGACAA CCTGTGGCCC ATGATCCTCA CTCTGCTGGT 2340

GGACTATACA CTCCAGACCT CGCTTAGCAT GGTAAATCAC CGGCTACAAA GCTTCTTTGG 2400

GGGGACAGTG ATGGGTGAGT CTGGCATGAA AACTGTGGAG GATGTAGGAA GCCCCCTCAA 2460

GTATGAATTC CAGGTGGGCC CAATGGGGGA GGGGCTGGTG GGCCTGGGGA CCCTGGTCCT 2520

AGGTCTGGAG TGGCCCTACG AAGTCAGCAA TGGCAAGTGG CTGCTGTATC CCACGGAGAT 2580 CACCGTCCAT GGCAATGGGT CCTGGCCCTG CCGACCACCT GGAGACCTTA TCAACCCTCT 2640

CAACCTCACT CTTTCTGACC CTGGGGACAG GCCATCATCC CCACAGCGCA GGCGCCGACA 2700

GCTGGATCCA GGGGGAGGCC AGGGCCCCCC ACCTGTCACT CTGGCTGCTG CCAAAAAAGC 2760

CAAGTCTGAG ACTGTGCTGA CCTGTGCCAC AGGGCGTGCC CACTGTGTGT GGCTAGAGTG 2820

CCCCATCCCT GATGCCCCCG TTGTCACCAA CGTGACTGTG AAGGCACGAG TGTGGAACAG 2880 CACCTTCATC GAGGATTACA GAGACTTTGA CCGAGTCCGG GTAAATGGCT GGGCTACCCT 2940

ATTCCTCCGA ACCAGCATCC CCACCATCAA CATGGAGAAC AAGACCACGT GGTTCTCTGT 3000

GGACATTGAC TCGGAGCTGG TGGAGGAGCT GCCGGCCGAA ATCGAGCTGT GGCTGGTGCT 3060

GGTGGCCGTG GGTGCAGGGC TGCTGCTGCT GGGGCTGATC ATCCTCCTGC TGTGGAAGTG 3120

TGACTTCTTT AAGCGGACCC GCTATTATCA GATCATGCCC AAGTACCACG CAGTGCGGAT 3180 ^' CCGGGAGGAG GAGCGCTACC CACCTCCAGG GAGCACCCTG CCCACCAAGA AGCACTGGGT 3240

GAGCAGCTGG CAGACTCGGG ACCAATACTA CTGACGTCCT CCCTGATCCC ACCCCCTCCT 3300

CCCCCAGTGT CCCCTTTCTT CCTATTTATC ATAAGTTATG CCTCTGACAG TCCACAGGGG 3360

CCACCACCTT TGGCTGGTAG CAGCAGGCTC AGGCACATAC ACCTCGTCAA GAGCATGCAC 3420

ATGCTGTCTG GCCCTGGGGA TCTTCCCACA GGAGGGCCAG CGCTGTGGAC CTTACAACGC 3480 CGAGTGCACT GCATTCCTGT GCCCTAGATG CACGTGGGGC CCACTGCTCG TGGACTGTGC 3540

TGGTGCATCA CGGATGGTGC ATGGGCTCGC CGTGTCTCAG CCTCTGCCAG CGCCAGCGCC 3600

AAAACAAGCC AAAGAGCCTC CCACCAGAGC CGGGAGGAAA AGGCCCCTGC AATGTGGTGA 3660

CACCTCCCCT TTCACACCTG GATCCATCTT GAGAGCCACA GTCACTGGAT TGACTTTGCT 3720

GTCAAAACTA CTGACAGGGA GCAGCCCCCG GGCCGCTGGC TGGTGGGCCC CCAATTGACA 3780 CCCATGCCAG AGAGGTGGGG ATCCTGCCTA AGGTTGTCTA CGGGGGCACT TGGAGGACCT 3840

GGCGTGCTCA GACCCAACAG CAAAGGAACT AGAAAGAAGG ACCCAGAAGG CTTGCTTTCC 3900

TGCATCTCTG TGAAGCCTCT CTCCTTGGCC ACAGACTGAA CTCGCAGGGA GTGCAGCAGβ 3960

AAGGAACAAA GACAGGCAAA CGGCAACGTA GCCTGGGCTC ACTGTGCTGG GGCATGGCGG 4020

GATCCTCCAC AGAGAGGAGG GGACCAATTC TGGACAGACA GATGTTGGGA GGATACAGAG 4080 GAGATGCCAC TTCTCACTCA CCACTACCAG CCAGCCTCCA GAAGGCCCCA GAGAGACCCT 4140

GCAAGACCAC GGAGGGAGCC GACACTTGAA TGTAGTAATA GGCAGGGGGC CCTGCCACCC 4200

CATCCAGCCA GACCCCAGCT GAACCATGCG TCAGGGGCCT AGAGGTGGAG TTCTTAGCTA 4260

TCCTTGGCTT TCTGTGCCAG CCTGGCTCTG CCCCTCCCCC ATGGGCTGTG TCCTAAGGCC 4320

CATTTGAGAA GCTGAGGCTA GTTCCAAAAA CCTCTCCTGA CCCCTGCCTG TTGGCAGCCC 4380 ACTCCCCAGC CCCAGCCCCT TCCATGGTAC TGTAGCAGGG GAATTCCCTC CCCCTCCTTG 4440 TGCCTTCTTT GTATATAGGC TTCTCACCGC GACCAATAAA CAGCTCCCAG TTTGT

Seq ID NO: 148 Protein sequence

Protein Accession ft: NP_005492.1

1 11 21 31 41 51

M IGPGPSRAPR AIPRLMLCALA LIMVAAGG.CW SIAFNLDTRFL WIKEAGNPGS LIFGYSVALHR 60

QTERQQRYLL LAGAPRELAV PDGYTNRTGA VYLCPLTAHK DDCERMNITV KNDPGHHIIE 120

DMWLGVTVAS QGPAGRVLVC AHRYTQVLWS GSEDQRRMVG KCYVRGNDLE LDSSDDWQTY 180

HNEMCNSNTD YLETGMCQLG TSGGFTQNTV YFGAPGAYNW KGNSYMIQRK EWDLSEYSYK 240

DPEDQGNLYI GYTMQVGSFI LHPKNITIVT GAPRHRHMGA VFLLSQEAGG DLRRRQVLEG 300

SQVGAYFGSA IALADLNNDG WQDLLVGAPY YFERKEEVGG AIYVFMNQAG TSFPAHPSLL 360

LHGPSGSAFG LSVASIGDIN QDGFQDIAVG APFEGLGKVY IYHSSSKGLL RQPQQVIHGE 420

KLGLPGLATF GYSLSGQMDV DENFYPDLLV GSLSDHIVLL RARPVINIVH KTLVPRPAVL 480 DPALCTATSC VQVELCFAYN QSAGNPNYRR NITLAYTLEA DRDRRPPRLR FAGSESAVFH 540

GFFSMPEMRC QKLELLLMDN LRDKLRPIII SMNYSLPLRM PDRPRLGLRS LDAYPILNQA 600

QALENHTEVQ FQKECGPDNK CESNLQMRAA FVSEQQQKLS RLQYSRDVRK LLLSINVTNT 660

RTSERSGEDA HEALLTLWP PALLLSSVRP PGACQANETI FCELGNPFKR NQRMELLIAF 720

EVIGVTLHTR DLQVQLQLST SSHQDNLWPM ILTLLVDYTL QTSLSMVNHR LQSFFGGTVM 780

GESGMKTVED VGSPLKYEFQ VGPMGEGLVG LGTLVLGLEW PYEVSNGKWL LYPTEITVHG 840 NGSWPCRPPG DLINPLNLTL SDPGDRPSSP QRRRRQLDPG GGQGPPPVTL AAAKKAKSET 900

VLTCATGRAH CVWLECPIPD APWTNVTVK ARVWNSTFIE DYRDFDRVRV NGWATLFLRT 960

SIPTINMENK TTWFSVDIDS ELVEELPAEI ELWLVLVAVG AGLLLLGLII LLLWKCDFFK 1020 RTRYYQIMPK YHAVRIREEE RYPPPGSTLP TKKHWVTSWQ TRDQYY

Seq ID NO: 149 DNA sequence Nucleic Acid Accession ft: NM_006424.1 Coding sequence: 1 11 21 31 41 51 i i i i i i

CGGGCCAGGT TTCCAGGCTC GGCCGCCGCC TCCATCCCAG CACCTGCGGA GGGAGCGCTG 60

ACCATGGCTC CCTGGCCTGA ATTGGGAGAT GCCCAGCCCA ACCCCGATAA GTACCTCGAA 120

GGGGCCGCAG GTCAGCAGCC CACTGCCCCT GATAAAAGCA AAGAGACCAA CAAAACAGAT 180

AACACTGAGG CACCTGTAAC CAAGATTGAA CTTCTGCCGT CCTACTCCAC GGCTACACTG 240

ATAGATGAGC CCACTGAGGT GGATGACCCC TGGAACCTAC CCACTCTTCA GGACTCGGGG 300

ATCAAGTGGT CAGAGAGAGA CACCAAAGGG AAGATTCTCT GTTTCTTCCA AGGGATTGGG 360

AGATTGATTT TACTTCTCGG ATTTCTCTAC TTTTTCGTGT GCTCCCTGGA TATTCTTAGT 420

AGCGCCTTCC AGCTGGTTGG AGGAAAAATG GCAGGACAGT TCTTCAGCAA CAGCTCTATT 480

ATGTCCAACC CTTTGTTGGG GCTGGTGATC GGGGTGCTGG TGACCGTCTT GGTGCAGAGC 540

TCCAGCACCT CAACGTCCAT CGTTGTCAGC ATGGTGTCCT CTTCATTGCT CACTGTTCGG 600

GCTGCCATCC CCATTATCAT GGGGGCCAAC ATTGGAACGT CAATCACCAA CACTATTGTT 660

GCGCTCATGC AGGTGGGAGA TCGGAGTGAG TTCAGAAGAG CTTTTGCAGG AGCCACTGTC 720

CATGACTTCT TCAACTGGCT GTCCGTGTTG GTGCTCTTGC CCGTGGAGGT GGCCACCCAT 780

TACCTCGAGA TCATAACCCA GCTTATAGTG GAGAGCTTCC ACTTCAAGAA TGGAGAAGAT 840

GCCCCAGATC TTCTGAAAGT CATCACTAAG CCCTTCACAA AGCTCATTGT CCAGCTGGAT 900

AAAAAAGTTA TCAGCCAAAT TGCAATGAAC GATGAAAAAG CGAAAAACAA GAGTCTTGTC 960

AAGATTTGGT GCAAAACTTT TACCAACAAG ACCCAGATTA ACGTCACTGT TCCCTCGACT 1020

GCTAACTGCA CCTCCCCTTC CCTCTGTTGG ACGGATGGCA TCCAAAACTG GACCATGAAG 1080

AATGTGACCT ACAAGGAGAA CATCGCCAAA TGCCAGCATA TCTTTGTGAA TTTCCACCTC 1140

CCGGATCTTG CTGTGGGCAC CATCTTGCTC ATACTCTCCC TGCTGGTCCT CTGTGGTTGC 1200

CTGATCATGA TTGTCAAGAT CCTGGGCTCT GTGCTCAAGG GGCAGGTCGC CACTGTCATC 1260

AAGAAGACCA TCAACACTGA TTTCCCCTTT CCCTTTGCAT GGTTGACTGG CTACCTGGCC 1320

ATCCTCGTCG GGGCAGGCAT GACCTTCATC GTACAGAGCA GCTCTGTGTT CACGTCGGCC 1380

TTGACCCCCC TGATTGGAAT CGGCGTGATA ACCATTGAGA GGGCTTATCC ACTCACGCTG 1440

GGCTCCAACA TCGGCACCAC CACCACCGCC ATCCTGGCCG CCTTAGCCAG CCCTGGCAAT 1500

GCATTGAGGA GTTCACTCCA GATCGCCCTG TGCCACTTTT TCTTCAACAT CTCCGGCATC 1560

TTGCTGTGGT ACCCGATCCC GTTCACTCGC CTGCCCATCC GCATGGCCAA GGGGCTGGGC 1620

AACATCTCTG CCAAGTATCG CTGGTTCGCC GTCTTCTACC TGATCATCTT CTTCTTCCTG 1680

ATCCCGCTGA CGGTGTTTGG CCTCTCGCTG GCCGGCTGGC GGGTGCTGGT TGGTGTCGGG 1740

GTTCCCGTCG TCTTCATCAT CATCCTGGTA CTGTGCCTCC GACTCCTGCA GTCTCGCTGC 1800

CCACGCGTCC TGCCGAAGAA ACTCCAGAAC TGGAACTTCC TGCCGCTGTG GATGCGCTCG 1860

CTGAAGCCCT GGGATGCCGT CGTCTCCAAG TTCACCGGCT GCTTCCAGAT GCGCTGCTGC 1920

TACTGCTGCC GCGTGTGCTG CCGCGCGTGC TGCTTGCTGT GTGGCTGCCC CAAGTGCTGC 1980

CGCTGCAGCA AGTGCTGGGA GGACTTGGAG GAGGCGCAGG AGGGGCAGGA TGTCCCTGTC 2040

AAGGCTCCTG AGACCTTTGA TAACATAACC ATTAGCAGAG AGGCTCAGGG TGAGGTCCCT 2100

GCCTCGGACT CAAAGACCGA ATGCACGGCC TTGTAGGGGA CGCCCCAGAT TGTCAGGGAT 2160

GGGGGGATGG TCCTTGAGTT TTGCATGCTC TCCTCCCTCC CACTTCTGCA CCCTTTCACC 2220 ACCTCGAGGA GATTTGCTCC CCATTAGCGA ATGAAATTGA TGCAGTCCTA AAAAAAAAAA

Seq ID NO: 150 Protein sequence: Protein Accession ft: NP_006415.1

1 11 21

MAPWPELGDA QPNPDKYLEG AAGQQPTAPD KSKETNKTDN TEAPVTKIEL LPSYSTATLI 60

DEPTEVDDPW NLPTLQDSGI KWSERDTKGK ILCFFQGIGR LILLLGFLYF FVCSLDILSS 120

AFQLVGGKMA GQFFSNSSIM SNPLLGLVIG VLVTVLVQSS ΞTSTSIWSM VSSSLLTVRA 180

AIPIIMGANI GTSITNTIVA LMQVGDRSEF RRAFAGATVH DFFNWLSVLV LLPVEVATHY 240

LEIITQLIVE SFHFKNGEDA PDLLKVITKP FTKLIVQLDK KVISQIAMND EKAKNKSLVK 300

IWCKTFTNKT QINVTVPSTA NCTSPSLCWT DGIQNWTMKN VTYKENIAKC QHIFVNFHLP 360

DLAVGTILLI LSLLVLCGCL IMIVKILGSV LKGQVATVIK KTINTDFPFP FAWLTGYLAI 420

LVGAGMTFIV QSSSVFTSAL TPLIGIGVIT IERAYPLTLG SNIGTTTTAI LAALASPGNA 480

LRSSLQIALC HFFFNISGIL LWYPIPFTRL PIRMAKGLGN ISAKYRWFAV FYLIIFFFLI 540

PLTVFGLSLA GWRVLVGVGV PWFIIILVL CLRLLQSRCP RVLPKKLQNW NFLPLWMRSL 600

KPWDAWSKF TGCFQMRCCY CCRVCCRACC LLCGCPKCCR CSKCCEDLEE AQEGQDVPVK 660 APETFDNITI SREAQGEVPA SDSKTECTAL

Seq ID NO: 151 DNA sequence

Nucleic Acid Accession ft:

Coding sequence: 1..1119

1 11 21 31 ^• 41 51

I I I I I I

ATGAACCGCA GCCACCGGCA CGGGGCGGGC AGCGGCTGCC TGGGCACTAT GGAGGTGAAG 60

AGCAAGTTTG GAGCTGAATT TCGTCGGTTT TCGCTGGAAA GATCAAAACC TGGAAAATTT 120

GAGGAGTTTT ATGGATTACT ACAACATGTT CATAAGATCC CCAATGTTGA CGTTTTGGTA 180

GGCTATGCAG ACATCCATGG AGACTTACTA CCTATAAATA ATGATGATAA TTATCACAAA 240

GCTGTTTCAA CGGCCAATCC ACTGCTTAGG ATATTTATAC AAAAGAAGGA AGAAGCAGAC 300

TACAGTGCCT TTGGTACAGA CACGCTAATA AAGAAGAAGA ATGTTTTAAC CAACGTATTG 360

CGTCCTGACA ACCATAGAAA AAAGCCACAT ATAGTCATTA GTATGCCCCA AGACTTTAGA 420

CCTGTGTCTT CTATTATAGA CGTGGATATT CTCCCAGAAA CGCATCGTAG GGTACGTCTT 480

TACAAATACG GCACGGAGAA ACCCCTAGGA TTCTACATCC GGGATGGCTC CAGTGTCAGG 540

GTAACACCAC ATGGCTTAGA AAAGGTTCCA GGGATCTTTA TATCCAGGCT TGTCCCAGGA 600

GGTCTGGCTC AAAGTACAGG ACTATTAGCT GTTAATGATG AAGTTTTAGA AGTTAATGGC 660

ATAGAAGTTT CAGGGAAGAG CCTTGATCAA GTAACAGACA TGATGATTGC AAATAGCCGT 720

AACCTCATCA -TAACAGTGAG ACCGGCAAAC CAGAGGAATA ATGTTGTGAG GAACAGTCGG 780

ACTTCTGGCA GTTCCGGTCA GTCTACTGAT AACAGCCTTC TTGGCTACCC ACAGCAGATT 840 GAACCAAGCT TTGAGCCAGA GGATGAAGAC AGCGAAGAAG ATGACATTAT CATTGAAGAC 900

AATGGAGTGC CACAGCAGAT TCCAAAAGCT GTTCCTAATA CTGAGAGCCT GGAGTCATTA 960

ACACAGATAG AGCTAAGCTT TGAGTCTGGA CAGAATGGCT TTATTCCCTC TAATGAAGTG 1020

AGCTTAGCAG CCATAGCAAG CAGCTCAAAC ACGGAATTTG AAACACATGC TCCAGATCAA 1080 5 AAACTCTTAG AAGAAGATGG AACAATCATA ACATTATGA

Seq ID NO: 152 Protein sequence Protein Accession ft: XP_030559 , - 1 11 21 31 41 51

10 I I I ^■ I I I

MNRSHRHGAG SGCLGTMEVK SKFGAEFRRF SLERSKPGKF EEFYGLLQHV HKIPNVDVLV 60

GYADIHGDLL PINNDDNYHK AVSTANPLLR IFIQKKEEAD YSAFGTDTLI KKKNVLTNVL 120

RPDNHRKKPH IVISMPQDFR PVSSIIDVDI LPETHRRVRL YKYGTEKPLG FYIRDGSSVR 180

VTPHGLEKVP GIFISRLVPG GLAQSTGLLA VNDEVLEVNG IEVSGKSLDQ VTDMMIANSR 240

15 NLIITVRPAN QRNNWRNSR TSGSSGQSTD NSLLGYPQQI EPSFEPEDED SEEDDIIIED 300

NGVPQQIPKA VPNTESLESL TQIELSFEΞG QNGFIPSNEV SLAAIASSSN TEFETHAPDQ 360 KLLEEDGTII TL

Seq ID NO: 153 DNA sequence 20 Nucleic Acid Accession ft: NM_003064.2 Coding sequence: 23..421 1 11 21 31 41 51

I I I I I I

CAGAGTCACT CCTGCCTTCA CCATGAAGTC CAGCGGCCTC TTCCCCTTCC TGGTGCTGCT 60

25 TGCCCTGGGA ACTCTGGCAC CTTGGGCTGT GGAAGGCTCT GGAAAGTCCT TCAAAGCTGG 120

AGTCTGTCCT CCTAAGAAAT CTGCCCAGTG CCTTAGATAC AAGAAACCTG AGTGCCAGAG 180

TGACTGGCAG TGTCCAGGGA AGAAGAGATG TTGTCCTGAC ACTTGTGGCA TCAAATGCCT 240

GGATCCTGTT GACACCCCAA ACCCAACAAG GAGGAAGCCT GGGAAGTGCC CAGTGACTTA 300

TGGCCAATGT TTGATGCTTA ACCCCCCCAA TTTCTGTGAG ATGGATGGCC AGTGCAAGCG 360

30 TGACTTGAAG TGTTGCATGG GCATGTGTGG GAAATCCTGC GTTTCCCCTG TGAAAGCTTG 420

ATTCCTGCCA TATGGAGGAG GCTCTGGAGT CCTGCTCTGT GTGGTCCAGG TCCTTTCCAC 480

CCTGAGACTT GGCTCCACCA CTGATATCCT CCTTTGGGGA AAGGCTTGGC ACACAGCAGG 540 CTTTCAAGAA GTGCCAGTTG ATCAATGAAT AAATAAACGA GCCTATTTCT CTTTGCAC

35 Seq ID NO: 154 Protein sequence

Protein Accession ft: NP_0030SS.l

1 11 21 31 41 51

I I I I I I

MKSSGLFPFL VLLALGTLAP WAVEGSGKSF KAGVCPPKKS AQCLRYKKPE CQSDWQCPGK 60 0 KRCCPDTCGI KCLDPVDTPN PTRRKPGKCP VTYGQCLMLN PPNFCEMDGQ CKRDLKCCMG 120 MCGKSCVSPV KA

Seq ID NO: 155 DNA sequence

Nucleic Acid Accession ft: NM_001306.1

45 Coding sequence: 199..861

1 11 21 31 41 51

I I I I I I

AATTCGGCAC GAGGGCAGGT GCAGGCGCAC GCGGCGAGAG CGTATGGAGC CGAGCCGTTA 60

GCGCGCGCCG TCGGTGAGTC AGTCCGTCCG TCCGTCCGTC CGTCGGGGCG CCGCAGCTCC 120

50 CGCCAGGCCC AGCGGCCCCG GCCCCTCGTC TCCCCGCACC CGGAGCCACC CGGTGGAGCG 180

GGCCTTGCCG CGGCAGCCAT GTCCATGGGC CTGGAGATCA CGGGCACCGC GCTGGCCGTG 240

CTGGGCTGGC TGGGCACCAT CGTGTGCTGC GCGTTGCCCA TGTGGCGCGT GTCGGCCTTC 300

ATCGGCAGCA ACATCATCAC GTCGCAGAAC ATCTGGGAGG GCCTGTGGAT GAACTGCGTG 360

GTGCAGAGCA CCGGCCAGAT GCAGTGCAAG GTGTACGACT CGCTGCTGGC ACTGCCACAG 420

55 GACCTTCAGG CGGCCCGCGC CCTCATCGTG GTGGCCATCC TGCTGGCCGC CTTCGGGCTG 480

CTAGTGGCGC TGGTGGGCGC CCAGTGCACC AACTGCGTGC AGGACGACAC GGCCAAGGCC 540

AAGATCACCA TCGTGGCAGG CGTGCTGTTC CTTCTCGCCG CCCTGCTCAC CCTCGTGCCG 600

GTGTCCTGGT CGGCCAACAC CATTATCCGG GACTTCTACA ACCCCGTGGT GCCCGAGGCG 660

CAGAAGCGCG AGATGGGCGC GGGCCTGTAC GTGGGCTGGG CGGCCGCGGC GCTGCAGCTG 720

60 CTGGGGGGCG CGCTGCTCTG CTGCTCGTGT CCCCCACGCG AGAAGAAGTA CACGGCCACC 780

AAGGTCGTCT ACTCCGCGCC GCGCTCCACC GGCCCGGGAG CCAGCCTGGG CACAGGCTAC 840

GACCGCAAGG ACTACGTCTA AGGGACAGAC GCAGGGAGAC CCCACCACCA CCACCACCAC 900

CAACACCACC ACCACCACCG CGAGCTGGAG CGCGCACCAG GCCATCCAGC GTGCAGCCTT 960

GCCTCGGAGG CCAGCCCACC CCCAGAAGCC AGGAAGCCCC CGCGCTGGAC TGGGGCAGCT 1020

65 TCCCCAGCAG CCACGGCTTT GCGGGCCGGG CAGTCGACTT CGGGGCCCAG GGACCAACCT 1080

GCATGGACTG TGAAACCTCA CCCTTCTGGA GCACGGGGCC TGGGTGACCG CCAATACTTG 1140

ACCACCCCGT CGAGCCCCAT CGGGCCGCTG CCCCCATGTC GCGCTGGGCA GGGACCGGCA 1200 GCCCTGGAAG GGGCACTTGA TATTTTTCAA TAAAAGCCTC TCGTTTTAGC

70 Seq ID NO: 156 Protein sequence

Protein Accession ft: NP_001297.1

1 11 21 31 41 51

I I I I I I

MSMGLEITGT ALAVLGWLGT IVCCALPMWR VSAFIGSNII TSQNIWEGLW MNCWQSTGQ 60

75 MQCKVYDSLL ALPQDLQAAR ALIWAILLA AFGLLVALVG AQCTNCVQDD TAKAKITIVA 120

GVLFLLAALL TLVPVSWSAN TIIRDFYNPV VPEAQKREMG AGLYVGWAAA ALQLLGGALL 180 CCSCPPREKK YTATKWYSA PRSTGPGASL GTGYDRKDYV

Seq ID NO: 157 DNA sequence

80 Nucleic Acid Accession ft: NM_00S564

Coding sequence: 1..597

1 11 21 31 41 51

I I I I I I

ATGCCCCTAG GTCTCCTGTG GCTGGGCCTA GCCCTGTTGG GGGCTCTGCA TGCCCAGGCC 60

85 CAGGACTCCA CCTCAGACCT GATCCCAGCC CCACCTCTGA GCAAGGTCCC TCTGCAGCAG 120 AACTTCCAGG ACAACCAATT CCAGGGGAAG TGGTATGTGG TAGGCCTGGC AGGGAATGCA 180

ATTCTCAGAG AAGACAAAGA CCCGCAAAAG ATGTATGCCA CCATCTATGA GCTGAAAGAA 240

GACAAGAGCT ACAATGTCAC CTCCGTCCTG TTTAGGAAAA AGAAGTGTGA CTACTGGATC 300

AGGACTTTTG TTCCAGGTTG CCAGCCCGGC GAGTTCACGC TGGGCAACAT TAAGAGTTAC 360 CCTGGATTAA CGAGTTACCT CGTCCGAGTG GTGAGCACCA ACTACAACCA GCATGCTATG 420

GTGTTCTTCA AGAAAGTTTC TCAAAACAGG GAGTACTTCA AGATCACCCT CTACGGGAGA 480

ACCAAGGAGC TGACTTCGGA ACTAAAGGAG AACTTCATCC GCTTCTCCAA ATATCTGGGC 540 CTCCCTGAAA ACCACATCGT CTTCCCTGTC CCAATCGACC AGTGTATCGA CGGCTGA Seq ID NO: 158 Protein sequence Protein Accession ft: NP_00555S 1 11 21 31 41 51

I I I I I I

MPLGLLWLGL ALLGALHAQA QDSTSDLIPA PPLSKVPLQQ NFQDNQFQGK WYWGLAGNA 60 ILREDKDPQK MYATIYELKE DKSYNVTSVL FRKKKCDYWI RTFVPGCQPG EFTLGNIKSY 120

PGLTSYLVRV VSTNYNQHAM VFFKKVSQNR EYFKITLYGR TKELTSELKE NFIRFSKYLG 180 LPENHIVFPV PIDQCIDG

Seq ID NO: 159 DNA sequence Nucleic Acid Accession ft: NM_006853.1 Coding sequence: 26..874 1 11 21 31 41 51

I I I I I I

AGGAATCTGC GCTCGGGTTC CGCAGATGCA GAGGTTGAGG TGGCTGCGGG ACTGGAAGTC 60 ATCGGGCAGA GGTCTCACAG CAGCCAAGGA ACCTGGGGCC CGCTCCTCCC CCCTCCAGGC 120

CATGAGGATT CTGCAGTTAA TCCTGCTTGC TCTGGCAACA GGGCTTGTAG GGGGAGAGAC 180

CAGGATCATC AAGGGGTTCG AGTGCAAGCC TCACTCCCAG CCCTGGCAGG CAGCCCTGTT 240

CGAGAAGACG CGGCTACTCT GTGGGGCGAC GCTCATCGCC CCCAGATGGC TCCTGACAGC 300

AGCCCACTGC CTCAAGCCCC GCTACATAGT TCACCTGGGG CAGCACAACC TCCAGAAGGA 360 GGAGGGCTGT GAGCAGACCC GGACAGCCAC TGAGTCCTTC CCCCACCCCG GCTTCAACAA 420

CAGCCTCCCC AACAAAGACC ACCGCAATGA CATCATGCTG GTGAAGATGG CATCGCCAGT 480

CTCCATCACC TGGGCTGTGC GACCCCTCAC CCTCTCCTCA CGCTGTGTCA CTGCTGGCAC 540

CAGCTGCCTC ATTTCCGGCT GGGGCAGCAC GTCCAGCCCC CAGTTACGCC TGCCTCACAC 600

CTTGCGATGC GCCAACATCA CCATCATTGA GCACCAGAAG TGTGAGAACG CCTACCCCGG 660 CAACATCACA GACACCATGG TGTGTGCCAG CGTGCAGGAA GGGGGCAAGG ACTCCTGCCA 720

GGGTGACTCC GGGGGCCCTC TGGTCTGTAA CCAGTCTCTT CAAGGCATTA TCTCCTGGGG 780

CCAGGATCCG TGTGCGATCA CCCGAAAGCC TGGTGTCTAC ACGAAAGTCT GCAAATATGT 840

GGACTGGATC CAGGAGACGA TGAAGAACAA TTAGACTGGA CCCACCCACC ACAGCCCATC 900

ACCCTCCATT TCCACTTGGT GTTTGGTTCC TGTTCACTCT GTTAATAAGA AACCCTAAGC 960 CAAGACCCTC TACGAACATT CTTTGGGCCT CCTGGACTAC AGGAGATGCT GTCACTTAAT 1020

AATCAACCTG GGGTTCGAAA TCAGTGAGAC CTGGATTCAA ATTCTGCCTT GAAATATTGT 1080

GACTCTGGGA ATGACAACAC CTGGTTTGTT CTCTGTTGTA TCCCCAGCCC CAAAGACAGC 1140

TCCTGGCCAT ATATCAAGGT TTCAATAAAT ATTTGCTAAA TGAGTG Seq ID NO: 160 Protein sequence Protein Accession ft: NP_006844.1 1 11 21 31 41 51

I I I I I I

MRILQLILLA LATGLVGGET RIIKGFECKP HSQPWQAALF EKTRLLCGAT LIAPRWLLTA 60 AHCLKPRYIV HLGQHNLQKE EGCEQTRTAT ESFPHPGFNN SLPNKDHRND IMLVKMASPV 120

SITWAVRPLT LSSRCVTAGT SCLISGWGST SSPQLRLPHT LRCANITIIE HQKCENAYPG 180

NITDTMVCAS VQEGGKDSCQ GDSGGPLVCN QSLQGIISWG QDPCAITRKP GVYTKVCKYV 240 DWIQETMKNN It is understood that the examples described above in no way serve to limit the true scope of this mvention, but rather are presented for illustrative purposes. All publications, sequences of accession numbers, and patent applications cited in this specification are herein incorporated by reference as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference.

Claims

WHAT IS CLAIMED IS:

1. A method of detecting an ovarian cancer-associated transcript in a cell from a patient, the method comprising contacting a biological sample from the patient with a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1-26.

2. The method of claim 1, wherein the biological sample comprises isolated nucleic acids.

3. The method of claim 2, wherein the nucleic acids are mRNA.

4. The method of claim 2, further comprising the step of amplifying nucleic acids before the step of contacting the biological sample with the polynucleotide.

5. The method of claim 1, wherein the polynucleotide comprises a sequence as shown in Tables 1-26.

6. The method of claim 1, wherein the polynucleotide is immobilized on a solid surface.

7. The method of claim 1, wherein the patient is undergoing a therapeutic regimen to treat ovarian cancer.

8. The method of claim 1, wherein the patient is suspected of having ovarian cancer.

9. An isolated nucleic acid molecule consisting of a polynucleotide sequence as shown in Tables 1-26.

10. The nucleic acid molecule of claim 9, which is labeled.

11. An expression vector comprising the nucleic acid of claim 9.

12. A host cell comprising the expression vector of claim 11.

13. An isolated polypeptide which is encoded by a nucleic acid molecule having polynucleotide sequence as shown in Tables 1-26.

14. An antibody that specifically binds a polypeptide of claim 13.

15. The antibody of claim 14, further conjugated to an effector component.

16. The antibody of claim 15, wherein the effector component is a fluorescent label.

17. The antibody of claim 15, wherein the effector component is a radioisotope or a cytotoxic chemical.

18. The antibody of claim 15 , which is an antibody fragment.

19. The antibody of claim 15, which is a humanized antibody

20. A method of detecting an ovarian cancer cell in a biological sample from a patient, the method comprising contacting the biological sample with an antibody of claim 14.

21. The method of claim 20, wherein the antibody is further conjugated to an effector component.

22. The method of claim 21 , wherein the effector component is a fluorescent label.

23. A method for identifying a compound that modulates an ovarian cancer-associated polypeptide, the method comprising the steps of: (i) contacting the compound with an ovarian cancer-associated polypeptide, the polypeptide encoded by a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1-26; and (ii) determining the functional effect ofthe compound upon the polypeptide.

24. A drug screening assay comprising the steps of (i) administering a test compound to a mammal having ovarian cancer or a cell isolated therefrom; (ii) comparing the level of gene expression of a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1-26 in a treated cell or mammal with the level of gene expression ofthe polynucleotide in a control cell or mammal, wherein a test compound that modulates the level of expression of the polynucleotide is a candidate for the treatment of ovarian cancer.