WO2003000312A3 - Method and device for subretinal drug delivery - Google Patents

Method and device for subretinal drug delivery Download PDF

Info

Publication number
WO2003000312A3
WO2003000312A3 PCT/US2002/019899 US0219899W WO03000312A3 WO 2003000312 A3 WO2003000312 A3 WO 2003000312A3 US 0219899 W US0219899 W US 0219899W WO 03000312 A3 WO03000312 A3 WO 03000312A3
Authority
WO
WIPO (PCT)
Prior art keywords
eye
devices
piercing member
drug delivery
cannula
Prior art date
Application number
PCT/US2002/019899
Other languages
French (fr)
Other versions
WO2003000312A2 (en
Inventor
Signe Erickson Varner
Eugene Dejuan Jr
Terry Harrison Shelley
Original Assignee
Univ Johns Hopkins
Signe Erickson Varner
Eugene Dejuan Jr
Terry Harrison Shelley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins, Signe Erickson Varner, Eugene Dejuan Jr, Terry Harrison Shelley filed Critical Univ Johns Hopkins
Priority to JP2003506953A priority Critical patent/JP4505219B2/en
Priority to CA2451663A priority patent/CA2451663C/en
Priority to EP02746643A priority patent/EP1404399A4/en
Priority to AU2002316350A priority patent/AU2002316350B2/en
Publication of WO2003000312A2 publication Critical patent/WO2003000312A2/en
Publication of WO2003000312A3 publication Critical patent/WO2003000312A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts

Abstract

Devices and devices for the treatment of the eye are disclosed. Preferred devices of the invention include a piercing member (12) that is inserted into the eye to create a pathway for a cannula(44). The cannula (44) is slidably mounted to the piercing member (12) and is adapted to reach a treatment site within the eye at which material is injected into and/or withdrawn from the eye. The outer diameter of the piercing member (12) is small enough to allow for self-sealing of the insertion site of the device upon the device's withdrawal therefrom. Also disclosed are methods for the utilizing the devices to treat the eye.
PCT/US2002/019899 2001-06-22 2002-06-21 Method and device for subretinal drug delivery WO2003000312A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2003506953A JP4505219B2 (en) 2001-06-22 2002-06-21 Methods and devices for subretinal drug delivery
CA2451663A CA2451663C (en) 2001-06-22 2002-06-21 Method and device for subretinal drug delivery
EP02746643A EP1404399A4 (en) 2001-06-22 2002-06-21 Method and device for subretinal drug delivery
AU2002316350A AU2002316350B2 (en) 2001-06-22 2002-06-21 Method and device for subretinal drug delivery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/888,079 US7485113B2 (en) 2001-06-22 2001-06-22 Method for drug delivery through the vitreous humor
US09/888,079 2001-06-22

Publications (2)

Publication Number Publication Date
WO2003000312A2 WO2003000312A2 (en) 2003-01-03
WO2003000312A3 true WO2003000312A3 (en) 2003-11-06

Family

ID=25392484

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/019899 WO2003000312A2 (en) 2001-06-22 2002-06-21 Method and device for subretinal drug delivery

Country Status (6)

Country Link
US (2) US7485113B2 (en)
EP (1) EP1404399A4 (en)
JP (1) JP4505219B2 (en)
AU (1) AU2002316350B2 (en)
CA (1) CA2451663C (en)
WO (1) WO2003000312A2 (en)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60135352D1 (en) * 2000-08-30 2008-09-25 Univ Johns Hopkins DEVICE FOR INTRA-OCCULAR ACTIVE AGGREGATION
US7316676B2 (en) * 2002-08-20 2008-01-08 Gholam A. Peyman Treatment of retinal detachment
CA2498489C (en) * 2002-09-29 2010-02-23 Surmodics, Inc. Method for subretinal administration of therapeutics including steroids;method for localizing pharmacodynamic action at the choroid and the retina; and related methods for treatment and/or prevention of retinal diseases
US7483750B2 (en) * 2003-03-21 2009-01-27 Second Sight Medical Products, Inc. Transretinal implant and method of implantation
ATE476960T1 (en) 2003-05-02 2010-08-15 Surmodics Inc SYSTEM FOR THE CONTROLLED RELEASE OF A BIOACTIVE INGREDIENT IN THE BACK OF THE EYE
US8246974B2 (en) 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
US20060110428A1 (en) * 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
DE102005009694B4 (en) * 2005-02-28 2007-05-03 Geuder Ag Ophthalmic set
CN101180086A (en) 2005-04-08 2008-05-14 苏尔莫迪克斯公司 Sustained release implants for subretinal delivery
EP1895957A1 (en) * 2005-05-18 2008-03-12 SurModics, Inc. Insertion instrument for non-linear medical devices
US20070009564A1 (en) * 2005-06-22 2007-01-11 Mcclain James B Drug/polymer composite materials and methods of making the same
US20090062909A1 (en) 2005-07-15 2009-03-05 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
CA2615452C (en) 2005-07-15 2015-03-31 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
CA2996768C (en) 2006-04-26 2020-12-08 Micell Technologies, Inc. Coatings containing multiple drugs
JP4872081B2 (en) * 2006-06-01 2012-02-08 国立大学法人徳島大学 Vitreous surgery cannula
CA2667228C (en) * 2006-10-23 2015-07-14 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
CA2679712C (en) * 2007-01-08 2016-11-15 Micell Technologies, Inc. Stents having biodegradable layers
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
CA2684482C (en) * 2007-04-17 2014-08-12 Micell Technologies, Inc. Stents having biodegradable layers
AU2008256684B2 (en) 2007-05-25 2012-06-14 Micell Technologies, Inc. Polymer films for medical device coating
US20090036827A1 (en) 2007-07-31 2009-02-05 Karl Cazzini Juxtascleral Drug Delivery and Ocular Implant System
WO2009051780A1 (en) * 2007-10-19 2009-04-23 Micell Technologies, Inc. Drug coated stents
US8353862B2 (en) * 2007-11-02 2013-01-15 Allergan, Inc. Drug delivery systems and methods
KR101725117B1 (en) * 2008-01-07 2017-04-10 살루타리스 메디컬 디바이스즈, 인코퍼레이티드 Devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye
US9873001B2 (en) 2008-01-07 2018-01-23 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive delivery of radiation to the eye
US8602959B1 (en) 2010-05-21 2013-12-10 Robert Park Methods and devices for delivery of radiation to the posterior portion of the eye
US8608632B1 (en) 2009-07-03 2013-12-17 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye
US10022558B1 (en) 2008-01-07 2018-07-17 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive delivery of radiation to the eye
US9056201B1 (en) 2008-01-07 2015-06-16 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive delivery of radiation to the eye
EP2271294B1 (en) 2008-04-17 2018-03-28 Micell Technologies, Inc. Stents having bioabsorbable layers
US20090318856A1 (en) * 2008-06-18 2009-12-24 Glaser Bert M Sampling Ocular Fluid
JP2011528275A (en) * 2008-07-17 2011-11-17 ミセル テクノロジーズ，インク． Drug delivery medical device
US7730628B2 (en) * 2008-09-05 2010-06-08 Bayer Schering Pharma Ag Depth stop devices and systems
EP2367527A2 (en) * 2008-11-26 2011-09-28 SurModics, Inc. Implantable ocular drug delivery device and methods
US8834913B2 (en) * 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
NL2002379C2 (en) * 2008-12-29 2010-06-30 D O R C Dutch Ophthalmic Res Ct International B V An ophthalmic device and an intravitreal method.
USD691270S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to an eye
USD691268S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to eye
USD691267S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to eye
USD691269S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to an eye
US20100239635A1 (en) * 2009-03-23 2010-09-23 Micell Technologies, Inc. Drug delivery medical device
CA2756307C (en) * 2009-03-23 2017-08-08 Micell Technologies, Inc. Peripheral stents having layers and reinforcement fibers
US8287494B2 (en) * 2009-03-23 2012-10-16 Colin Ma Intravitreal injection devices and methods of injecting a substance into the vitreous chamber of the eye
CN102481195B (en) * 2009-04-01 2015-03-25 米歇尔技术公司 Drug delivery medical device
WO2010121187A2 (en) 2009-04-17 2010-10-21 Micell Techologies, Inc. Stents having controlled elution
US20120191064A1 (en) * 2009-05-15 2012-07-26 Iscience Interventional Corporation Methods and apparatus for sub-retinal catheterization
EP2453834A4 (en) 2009-07-16 2014-04-16 Micell Technologies Inc Drug delivery medical device
JP2013501579A (en) * 2009-08-10 2013-01-17 サーモディクス，インコーポレイテッド Methods, devices and compositions for intravitreal injection
US20110166555A1 (en) * 2009-09-30 2011-07-07 Jianbo Zhou Carrier for an insertable medical device, insertion tools, methods of use, and kits
EP2496304A4 (en) * 2009-11-02 2013-04-17 Salutaris Medical Devices Inc Methods and devices for delivering appropriate minimally-invasive extraocular radiation
US20110112469A1 (en) * 2009-11-08 2011-05-12 Powerscope Incorporated Device and process for dispensing multiple-phase mixtures
US8343106B2 (en) * 2009-12-23 2013-01-01 Alcon Research, Ltd. Ophthalmic valved trocar vent
BR112012017771B1 (en) * 2009-12-23 2020-07-14 Alcon Research, Llc VALVE TROCART CANNULA
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
US11369498B2 (en) * 2010-02-02 2022-06-28 MT Acquisition Holdings LLC Stent and stent delivery system with improved deliverability
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
WO2011133655A1 (en) 2010-04-22 2011-10-27 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
CA2805631C (en) 2010-07-16 2018-07-31 Micell Technologies, Inc. Drug delivery medical device
US10285852B2 (en) * 2010-12-02 2019-05-14 Tel Hashomer Medical Research Infrastructure And Services Ltd., The Chaim Sheba Medical Center Subretinal delivery of therapeutic compositions
WO2012166819A1 (en) 2011-05-31 2012-12-06 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
CA2841360A1 (en) 2011-07-15 2013-01-24 Micell Technologies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
JP6549482B2 (en) 2012-06-01 2019-07-24 サーモディクス，インコーポレイテッド Device and method for coating a balloon catheter
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
US9757536B2 (en) 2012-07-17 2017-09-12 Novartis Ag Soft tip cannula
JP6084408B2 (en) * 2012-09-07 2017-02-22 Hoya株式会社 Surgical instruments
KR20150143476A (en) 2013-03-12 2015-12-23 미셀 테크놀로지즈, 인코포레이티드 Bioabsorbable biomedical implants
KR102079613B1 (en) 2013-05-15 2020-02-20 미셀 테크놀로지즈, 인코포레이티드 Bioabsorbable biomedical implants
EP3003235B1 (en) * 2013-05-31 2021-09-29 The Regents of The University of Colorado, A Body Corporate Devices for creating a predictable capsulorhexis of specific diameter
WO2015119921A1 (en) 2014-02-06 2015-08-13 Novartis Ag Manufacturing an articulating ophthalmic surgical probe
US9925088B2 (en) * 2014-06-06 2018-03-27 Janssen Biotech, Inc. Sub-retinal tangential needle catheter guide and introducer
US9949874B2 (en) * 2014-06-06 2018-04-24 Janssen Biotech, Inc. Therapeutic agent delivery device with convergent lumen
US10391206B2 (en) 2014-07-30 2019-08-27 University Of Kansas Cannula for external drainage of subretinal fluid
USD814637S1 (en) 2016-05-11 2018-04-03 Salutaris Medical Devices, Inc. Brachytherapy device
USD815285S1 (en) 2016-05-11 2018-04-10 Salutaris Medical Devices, Inc. Brachytherapy device
USD814638S1 (en) 2016-05-11 2018-04-03 Salutaris Medical Devices, Inc. Brachytherapy device
US10463532B2 (en) 2016-07-26 2019-11-05 Masatoshi Murata Method for placing implant in choroid that can less invasively and simply place implant in choroid in optic disc-macula area
USD808528S1 (en) 2016-08-31 2018-01-23 Salutaris Medical Devices, Inc. Holder for a brachytherapy device
USD808529S1 (en) 2016-08-31 2018-01-23 Salutaris Medical Devices, Inc. Holder for a brachytherapy device
US11628466B2 (en) 2018-11-29 2023-04-18 Surmodics, Inc. Apparatus and methods for coating medical devices
US11759355B1 (en) 2019-02-26 2023-09-19 Gyroscope Therapeutics Limited Method of delivering leading blebs and agent to subretinal space
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5326345A (en) * 1991-08-14 1994-07-05 Price Jr Francis W Eye filtration prostheses

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3598119A (en) 1970-02-02 1971-08-10 Charles A White Continuous paracervical anesthesia method and device
US3659610A (en) 1970-04-14 1972-05-02 Hugo S Cimber Aspirator needle injector
US4002169A (en) * 1972-04-18 1977-01-11 Cupler Ii John A Method and apparatus for performing surgery without tissue incision
CA1221596A (en) 1984-03-09 1987-05-12 David Evans Surgical needle
US4710171A (en) 1986-06-09 1987-12-01 The Kendall Company Needle depth setting sheath assembly and needle stop
US4781691A (en) 1987-07-17 1988-11-01 The Kendall Company Stepped needle
US4909784A (en) * 1988-03-25 1990-03-20 Seymour Dubroff Method for preventing clouding of posterior capsule after extracapsular cataract eye surgery
US4869717A (en) * 1988-04-25 1989-09-26 Adair Edwin Lloyd Gas insufflation needle with instrument port
US5066276A (en) 1988-06-21 1991-11-19 Alcon Laboratories, Inc. Method and apparatus for injecting viscous fluid into the eye to lift pre-retinal and post-retinal membrane with linear pressure control
US4978334A (en) 1988-09-08 1990-12-18 Toye Frederic J Apparatus and method for providing passage into body viscus
SG49267A1 (en) 1989-08-14 1998-05-18 Photogenesis Inc Surgical instrument and cell isolation and transplantation
JPH0399653A (en) 1989-09-13 1991-04-24 Terumo Corp Puncturing needle
US5273530A (en) * 1990-11-14 1993-12-28 The University Of Rochester Intraretinal delivery and withdrawal instruments
JP2660455B2 (en) * 1991-02-08 1997-10-08 東洋鋼鈑株式会社 Heat resistant hard sintered alloy
US5827236A (en) 1992-11-10 1998-10-27 Seikagaku Kogyo Kabushiki Kaisha Injection tool and method of its use
US5487725A (en) 1994-05-12 1996-01-30 Syntec, Inc. Pneumatic vitrectomy for retinal attachment
US5792099A (en) 1995-02-14 1998-08-11 Decamp; Dennis Syringe and cannula for insertion of viscoelastic material into an eye and method of using same
US6824553B1 (en) * 1995-04-28 2004-11-30 Target Therapeutics, Inc. High performance braided catheter
JPH1085331A (en) * 1996-07-26 1998-04-07 Asahi Optical Co Ltd Injection tool for endoscope
US5984889A (en) 1996-02-23 1999-11-16 Allergan Sales, Inc. Apparatus and method for delivering viscoelastic material to an eye
US5989262A (en) * 1996-04-15 1999-11-23 Josephberg; Robert Gary Sutureless pars plana vitrectomy tool
AUPO394496A0 (en) * 1996-11-29 1997-01-02 Lions Eye Institute Biological microfistula tube and implantation method and apparatus
US5871470A (en) 1997-04-18 1999-02-16 Becton Dickinson And Company Combined spinal epidural needle set
DE19725680C2 (en) 1997-06-18 2000-04-06 Hans Haindl Funnel-shaped cannula arrangement for catheter insertion
US5997486A (en) * 1998-04-24 1999-12-07 Denver Biomaterials, Inc. Device for paracentisis and thoracentisis
US6402734B1 (en) 1998-07-02 2002-06-11 Jeffrey N. Weiss Apparatus and method for cannulating retinal blood vessels
US6024719A (en) * 1998-07-06 2000-02-15 Morris; Robert E Method and apparatus for performing surgery inside the human retina using fluidic internal limiting membrane (ILM) seperation (FILMS)
US6378526B1 (en) * 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
US6309374B1 (en) * 1998-08-03 2001-10-30 Insite Vision Incorporated Injection apparatus and method of using same
US6585972B2 (en) * 1999-03-09 2003-07-01 Gholam A. Peyman Process for crosslinking of collagen in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina
US6319230B1 (en) * 1999-05-07 2001-11-20 Scimed Life Systems, Inc. Lateral needle injection apparatus and method
US6428553B1 (en) * 2000-03-08 2002-08-06 Nuvue Technologies, Inc. Illuminated ophthalmic membrane pick assembly
US6641564B1 (en) * 2000-11-06 2003-11-04 Medamicus, Inc. Safety introducer apparatus and method therefor
US20030171722A1 (en) * 2001-01-04 2003-09-11 Michel Paques Microsurgical injection and/or distending instruments and surgical method and apparatus utilizing same
US7122042B2 (en) * 2001-03-15 2006-10-17 Lorusso Frank J Apparatuses and methods for transcleral cautery and subretinal drainage
US20030158521A1 (en) 2002-02-21 2003-08-21 Ameri Darius M. Trocar placement guide needle

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5326345A (en) * 1991-08-14 1994-07-05 Price Jr Francis W Eye filtration prostheses

Also Published As

Publication number Publication date
US20080154204A1 (en) 2008-06-26
JP4505219B2 (en) 2010-07-21
CA2451663C (en) 2012-12-04
JP2005516636A (en) 2005-06-09
EP1404399A2 (en) 2004-04-07
WO2003000312A2 (en) 2003-01-03
US20020198511A1 (en) 2002-12-26
EP1404399A4 (en) 2008-07-23
CA2451663A1 (en) 2003-01-03
AU2002316350B2 (en) 2008-06-05
US7485113B2 (en) 2009-02-03

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