WO2003000851A3 - Method for rapid screening of bacterial transformants and novel simian adenovirus proteins - Google Patents
Method for rapid screening of bacterial transformants and novel simian adenovirus proteins Download PDFInfo
- Publication number
- WO2003000851A3 WO2003000851A3 PCT/US2002/019735 US0219735W WO03000851A3 WO 2003000851 A3 WO2003000851 A3 WO 2003000851A3 US 0219735 W US0219735 W US 0219735W WO 03000851 A3 WO03000851 A3 WO 03000851A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- proteins
- rapid screening
- simian adenovirus
- adenovirus proteins
- bacterial transformants
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 238000012216 screening Methods 0.000 title abstract 2
- 230000001580 bacterial effect Effects 0.000 title 1
- 241000990167 unclassified Simian adenoviruses Species 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 241000282577 Pan troglodytes Species 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 241000701161 unidentified adenovirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES02756264T ES2375557T3 (en) | 2001-06-22 | 2002-06-20 | ADENOVIRUS RECOMBINANTS THAT UNDERSTAND PROTEIN OF ADEOVIRUS OF AIMS AND USES OF THE SAME. |
AU2002322285A AU2002322285A1 (en) | 2001-06-22 | 2002-06-20 | Method for rapid screening of bacterial transformants and novel simian adenovirus proteins |
AT02756264T ATE530672T1 (en) | 2001-06-22 | 2002-06-20 | RECOMBINANT ADENOVIRUSES WITH MONKEY ADENOVIRUS PROTEINS AND USE THEREOF. |
US10/477,527 US7344872B2 (en) | 2001-06-22 | 2002-06-20 | Method for rapid screening of bacterial transformants and novel simian adenovirus proteins |
JP2003507238A JP4399255B2 (en) | 2001-06-22 | 2002-06-20 | A method for rapid selection of bacterial transformants and a novel simian adenovirus protein |
EP02756264A EP1409748B1 (en) | 2001-06-22 | 2002-06-20 | Recombinant Adenoviruses comprising simian adenovirus proteins and uses thereof. |
CA2450470A CA2450470C (en) | 2001-06-22 | 2002-06-20 | Method for rapid screening of bacterial transformants and novel simian adenovirus proteins |
US12/011,377 US7838277B2 (en) | 2001-06-22 | 2008-01-25 | Method for rapid screening of bacterial transformants and novel simian adenovirus proteins |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30050101P | 2001-06-22 | 2001-06-22 | |
US60/300,501 | 2001-06-22 | ||
US38563202P | 2002-06-04 | 2002-06-04 | |
US60/385,632 | 2002-06-04 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10477527 A-371-Of-International | 2002-06-20 | ||
US12/011,377 Division US7838277B2 (en) | 2001-06-22 | 2008-01-25 | Method for rapid screening of bacterial transformants and novel simian adenovirus proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003000851A2 WO2003000851A2 (en) | 2003-01-03 |
WO2003000851A3 true WO2003000851A3 (en) | 2003-02-20 |
Family
ID=26971814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/019735 WO2003000851A2 (en) | 2001-06-22 | 2002-06-20 | Method for rapid screening of bacterial transformants and novel simian adenovirus proteins |
Country Status (8)
Country | Link |
---|---|
US (2) | US7344872B2 (en) |
EP (1) | EP1409748B1 (en) |
JP (1) | JP4399255B2 (en) |
AT (1) | ATE530672T1 (en) |
AU (1) | AU2002322285A1 (en) |
CA (1) | CA2450470C (en) |
ES (1) | ES2375557T3 (en) |
WO (1) | WO2003000851A2 (en) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3928858A1 (en) * | 1989-08-31 | 1991-03-07 | Beiersdorf Ag | NETWORKED HYDROGELES AND METHOD FOR THE PRODUCTION THEREOF |
US20040136963A1 (en) * | 2001-06-22 | 2004-07-15 | The Trustees Of The University Of Pennsylvania | Simian adenovirus vectors and methods of use |
CA2450470C (en) | 2001-06-22 | 2012-08-28 | The Trustees Of The University Of Pennsylvania | Method for rapid screening of bacterial transformants and novel simian adenovirus proteins |
CA2466431C (en) | 2001-11-21 | 2014-08-05 | The Trustees Of The University Of Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
US7291498B2 (en) | 2003-06-20 | 2007-11-06 | The Trustees Of The University Of Pennsylvania | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
US7491508B2 (en) | 2003-06-20 | 2009-02-17 | The Trustees Of The University Of Pennsylvania | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
AU2011247887B2 (en) * | 2004-01-23 | 2014-11-20 | Msd Italia S.R.L. | Chimpanzee adenovirus vaccine carriers |
LT2163260T (en) * | 2004-01-23 | 2017-06-26 | Msd Italia S.R.L. | Chimpanzee adenovirus vaccine carriers |
JP2008500364A (en) * | 2004-05-25 | 2008-01-10 | キメラコア, インコーポレイテッド | Self-assembling nanoparticle drug delivery system |
ATE492643T1 (en) * | 2004-10-13 | 2011-01-15 | Crucell Holland Bv | IMPROVED ADENOVIRUS VECTORS AND THEIR USE |
NZ581306A (en) | 2004-11-16 | 2011-03-31 | Crucell Holland Bv | Multivalent vaccines comprising recombinant viral vectors |
EP1893636A2 (en) | 2005-06-17 | 2008-03-05 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Hepatitis c virus nucleic acid vaccine |
AU2007348315A1 (en) * | 2006-04-07 | 2008-09-12 | Chimeros, Inc. | Compositions and methods for treating B- cell malignancies |
CA2683063A1 (en) * | 2007-04-09 | 2008-10-16 | Chimeros, Inc. | Self-assembling nanoparticle drug delivery system |
KR101761683B1 (en) | 2007-11-28 | 2017-07-26 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Simian subfamily b adenoviruses sadv-28,27,-29,-32,-33, and -35 and uses thereof |
EP2463362B1 (en) * | 2007-11-28 | 2017-11-08 | The Trustees Of The University Of Pennsylvania | Simian subfamily c adenovirus SAdv-31 and uses thereof |
PL2220241T3 (en) * | 2007-11-28 | 2017-06-30 | The Trustees Of The University Of Pennsylvania | Adenovirus comprising a Simian E Adenovirus SAdV-39 capsid hexon protein and uses thereof |
EP2250255A2 (en) | 2008-03-04 | 2010-11-17 | The Trustees of the University of Pennsylvania | Simian adenoviruses sadv-36,-42.1, -42.2, and -44 and uses thereof |
US9217155B2 (en) | 2008-05-28 | 2015-12-22 | University Of Massachusetts | Isolation of novel AAV'S and uses thereof |
JP5809978B2 (en) * | 2008-10-31 | 2015-11-11 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | Simian adenovirus SAdV-43, -45, -46, -47, -48, -49 and -50 and their uses |
DK2391638T3 (en) * | 2009-02-02 | 2018-08-27 | Glaxosmithkline Biologicals Sa | Abeadenovirus nucleic acid and amino acid sequences, vectors containing them, and uses thereof. |
SG172935A1 (en) | 2009-02-02 | 2011-08-29 | Okairos Ag | Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof |
WO2010120874A2 (en) | 2009-04-14 | 2010-10-21 | Chimeros, Inc. | Chimeric therapeutics, compositions, and methods for using same |
WO2010138263A2 (en) | 2009-05-28 | 2010-12-02 | University Of Massachusetts | Novel aav 's and uses thereof |
CA2762203A1 (en) | 2009-05-29 | 2010-12-02 | Soumitra Roy | Simian adenovirus 41 and uses thereof |
WO2011133890A1 (en) | 2010-04-23 | 2011-10-27 | University Of Massachusetts | Cns targeting aav vectors and methods of use thereof |
CA2833905C (en) | 2010-04-23 | 2019-09-10 | University Of Massachusetts | Multicistronic expression constructs |
JP2013533847A (en) | 2010-04-23 | 2013-08-29 | ユニバーシティ オブ マサチューセッツ | AAV-based treatment of cholesterol-related disorders |
CN103118702A (en) | 2010-09-20 | 2013-05-22 | 克鲁塞尔荷兰公司 | Therapeutic vaccination against active tuberculosis |
WO2012071318A2 (en) | 2010-11-23 | 2012-05-31 | The Trustees Of The University Of Pennsylvania | Subfamily e simian adenoviruses a1321, a1325, a1295, a1309, a1316 and a1322 and uses thereof |
JP2014527072A (en) | 2011-09-09 | 2014-10-09 | バイオメド リアルティー, エル.ピー. | Methods and compositions for controlling the assembly of viral proteins |
MX358019B (en) | 2012-05-18 | 2018-08-02 | Univ Pennsylvania | Subfamily e simian adenoviruses a1302, a1320, a1331 and a1337 and uses thereof. |
KR102089121B1 (en) | 2013-03-14 | 2020-03-13 | 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 | Oncolytic adenovirus compositions |
BR112016008806A2 (en) | 2013-11-01 | 2017-10-03 | Pfizer | VECTORS FOR EXPRESSION OF PROSTATE-ASSOCIATED ANTIGENS |
WO2015191508A1 (en) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Chimeric capsids |
CN107073051B (en) | 2014-10-21 | 2021-08-24 | 马萨诸塞大学 | Recombinant AAV variants and uses thereof |
JP6401871B2 (en) | 2014-11-05 | 2018-10-10 | ボイジャー セラピューティクス インコーポレイテッドVoyager Therapeutics,Inc. | AADC polynucleotide for the treatment of Parkinson's disease |
SG11201703419UA (en) | 2014-11-14 | 2017-05-30 | Voyager Therapeutics Inc | Modulatory polynucleotides |
EP3218484A4 (en) | 2014-11-14 | 2018-05-30 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
EP3230441A4 (en) | 2014-12-12 | 2018-10-03 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scaav |
US10983110B2 (en) | 2015-12-02 | 2021-04-20 | Voyager Therapeutics, Inc. | Assays for the detection of AAV neutralizing antibodies |
AU2017222568B2 (en) | 2016-02-23 | 2020-09-10 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
KR20220163505A (en) | 2016-02-23 | 2022-12-09 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics |
WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
EP3458588A4 (en) | 2016-05-18 | 2020-01-15 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
WO2017201258A1 (en) | 2016-05-18 | 2017-11-23 | Voyager Therapeutics, Inc. | Compositions and methods of treating huntington's disease |
WO2018035388A1 (en) | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
US20200283743A1 (en) | 2016-08-17 | 2020-09-10 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
EP3831281A1 (en) | 2016-08-30 | 2021-06-09 | The Regents of The University of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
AU2017341849B2 (en) | 2016-10-13 | 2024-03-21 | University Of Massachusetts | AAV capsid designs |
AU2017375633C1 (en) | 2016-12-12 | 2023-04-27 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
US20200405639A1 (en) | 2017-04-14 | 2020-12-31 | The Broad Institute, Inc. | Novel delivery of large payloads |
JP2020518258A (en) | 2017-05-05 | 2020-06-25 | ボイジャー セラピューティクス インコーポレイテッドVoyager Therapeutics,Inc. | Amyotrophic lateral sclerosis (ALS) treatment composition and method |
WO2018204803A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Compositions and methods of treating huntington's disease |
TW202333779A (en) | 2017-05-08 | 2023-09-01 | 美商磨石生物公司 | Alphavirus neoantigen vectors |
JOP20190269A1 (en) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | Aadc polynucleotides for the treatment of parkinson's disease |
US11497576B2 (en) | 2017-07-17 | 2022-11-15 | Voyager Therapeutics, Inc. | Trajectory array guide system |
EP3808849A1 (en) | 2017-08-03 | 2021-04-21 | Voyager Therapeutics, Inc. | Compositions and methods for delivery of aav |
AU2018352236A1 (en) | 2017-10-16 | 2020-04-23 | The Curators Of The University Of Missouri | Treatment of amyotrophic lateral sclerosis (ALS) |
WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
EP3710039A4 (en) | 2017-11-13 | 2021-08-04 | The Broad Institute, Inc. | Methods and compositions for treating cancer by targeting the clec2d-klrb1 pathway |
US20220153871A1 (en) | 2018-01-04 | 2022-05-19 | Iconic Therapeutics, Inc. | Anti-Tissue Factor Antibodies, Antibody-Drug Conjugates, and Related Methods |
EP3807404A1 (en) | 2018-06-13 | 2021-04-21 | Voyager Therapeutics, Inc. | Engineered 5' untranslated regions (5' utr) for aav production |
EP3826719A1 (en) | 2018-07-24 | 2021-06-02 | Voyager Therapeutics, Inc. | Systems and methods for producing gene therapy formulations |
TW202035689A (en) | 2018-10-04 | 2020-10-01 | 美商航海家醫療公司 | Methods for measuring the titer and potency of viral vector particles |
SG11202103425YA (en) | 2018-10-05 | 2021-05-28 | Voyager Therapeutics Inc | Engineered nucleic acid constructs encoding aav production proteins |
WO2020081490A1 (en) | 2018-10-15 | 2020-04-23 | Voyager Therapeutics, Inc. | EXPRESSION VECTORS FOR LARGE-SCALE PRODUCTION OF rAAV IN THE BACULOVIRUS/Sf9 SYSTEM |
AU2019406778A1 (en) | 2018-12-17 | 2021-07-22 | Massachusetts Institute Of Technology | Crispr-associated transposase systems and methods of use thereof |
EP3917566A4 (en) | 2019-01-31 | 2022-10-26 | Oregon Health & Science University | Methods for using transcription-dependent directed evolution of aav capsids |
US20220220469A1 (en) | 2019-05-20 | 2022-07-14 | The Broad Institute, Inc. | Non-class i multi-component nucleic acid targeting systems |
BR122024002387A2 (en) | 2019-05-30 | 2024-03-12 | Gritstone Bio, Inc. | ADENOVIRUS VECTORS, PHARMACEUTICAL COMPOSITION, ISOLATED NUCLEOTIDE SEQUENCE, ISOLATED CELL, VECTOR, KIT, USES OF A VECTOR, METHOD FOR MAKING THE VECTOR, METHODS FOR PRODUCING A VIRUS AND VIRAL VECTOR |
AU2021320896A1 (en) | 2020-08-06 | 2023-03-23 | Gritstone Bio, Inc. | Multiepitope vaccine cassettes |
BR112023015303A2 (en) | 2021-02-01 | 2023-11-14 | Regenxbio Inc | METHOD TO TREAT CLN2 DISEASE DUE TO TPP1 DEFICIENCY IN A SUBJECT |
WO2023196818A1 (en) | 2022-04-04 | 2023-10-12 | The Regents Of The University Of California | Genetic complementation compositions and methods |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6083716A (en) * | 1996-09-06 | 2000-07-04 | The Trustees Of The University Of Pennsylvania | Chimpanzee adenovirus vectors |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5770442A (en) | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
US5922315A (en) | 1997-01-24 | 1999-07-13 | Genetic Therapy, Inc. | Adenoviruses having altered hexon proteins |
CA2321135A1 (en) | 1998-02-17 | 1999-08-19 | Uab Research Foundation | Modified adenovirus containing a fiber replacement protein |
US20030017138A1 (en) * | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
CA2450470C (en) | 2001-06-22 | 2012-08-28 | The Trustees Of The University Of Pennsylvania | Method for rapid screening of bacterial transformants and novel simian adenovirus proteins |
US20030092161A1 (en) * | 2001-09-19 | 2003-05-15 | The Trustees Of The University Of Pennsylvania | Compositions and methods for production of recombinant viruses, and uses therefor |
CA2466431C (en) | 2001-11-21 | 2014-08-05 | The Trustees Of The University Of Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
US7291498B2 (en) * | 2003-06-20 | 2007-11-06 | The Trustees Of The University Of Pennsylvania | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
US7491508B2 (en) * | 2003-06-20 | 2009-02-17 | The Trustees Of The University Of Pennsylvania | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
FR2860004A1 (en) | 2003-09-18 | 2005-03-25 | Roussy Inst Gustave | Adenoviral vector encoding modified capsid protein, useful in gene therapy of e.g. cancer and cystic fibrosis, can infect cells deficient in, or lacking, the common receptor for Coxsackie virus B3 and adenovirus |
DE602007004470D1 (en) * | 2006-04-28 | 2010-03-11 | Univ Pennsylvania | MODIFIED ADENOVIRUS HEXON PROTEIN AND APPLICATIONS THEREOF |
-
2002
- 2002-06-20 CA CA2450470A patent/CA2450470C/en not_active Expired - Fee Related
- 2002-06-20 US US10/477,527 patent/US7344872B2/en not_active Expired - Lifetime
- 2002-06-20 AU AU2002322285A patent/AU2002322285A1/en not_active Abandoned
- 2002-06-20 ES ES02756264T patent/ES2375557T3/en not_active Expired - Lifetime
- 2002-06-20 EP EP02756264A patent/EP1409748B1/en not_active Expired - Lifetime
- 2002-06-20 AT AT02756264T patent/ATE530672T1/en not_active IP Right Cessation
- 2002-06-20 JP JP2003507238A patent/JP4399255B2/en not_active Expired - Fee Related
- 2002-06-20 WO PCT/US2002/019735 patent/WO2003000851A2/en active Application Filing
-
2008
- 2008-01-25 US US12/011,377 patent/US7838277B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6083716A (en) * | 1996-09-06 | 2000-07-04 | The Trustees Of The University Of Pennsylvania | Chimpanzee adenovirus vectors |
Also Published As
Publication number | Publication date |
---|---|
EP1409748B1 (en) | 2011-10-26 |
US20040171807A1 (en) | 2004-09-02 |
CA2450470C (en) | 2012-08-28 |
JP4399255B2 (en) | 2010-01-13 |
CA2450470A1 (en) | 2003-01-03 |
US20080219954A1 (en) | 2008-09-11 |
ES2375557T3 (en) | 2012-03-02 |
JP2004537300A (en) | 2004-12-16 |
WO2003000851A2 (en) | 2003-01-03 |
EP1409748A4 (en) | 2005-03-30 |
AU2002322285A1 (en) | 2003-01-08 |
US7344872B2 (en) | 2008-03-18 |
EP1409748A2 (en) | 2004-04-21 |
US7838277B2 (en) | 2010-11-23 |
ATE530672T1 (en) | 2011-11-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2003000851A3 (en) | Method for rapid screening of bacterial transformants and novel simian adenovirus proteins | |
WO1997033996A3 (en) | Human bikunin | |
CA2277832A1 (en) | Cyclic peptides that bind to urokinase-type plasminogen activator receptor | |
EP2258383A3 (en) | Antigenic peptides derived from telomerase | |
EP1612272A3 (en) | Novel antiangiogenic peptides, polynucleotides encoding same and methods for inhibiting angiogenesis | |
AU1873199A (en) | Method of identifying binding site domains that retain the capacity of binding to an epitope | |
WO2001052875A8 (en) | Vegf-d/vegf-c/vegf peptidomimetic inhibitor | |
BG102983A (en) | Extramembrane protein 106 polypeptide of moraxella catarrhalis, its gene sequence and application | |
CA2321177A1 (en) | Recombinant fibronectin-based extracellular matrix for wound healing | |
NO960767L (en) | Protocadherin proteins and their use | |
PT737207E (en) | HUMAN PLASMA INHIBITORS DERIVED FROM KUNITZ DOMAINS | |
EP2110385A8 (en) | Stabilized factor VIII with engineered disulfide bonds | |
AU4723596A (en) | Method for preparing a recombinant adenovirus genome | |
WO2006131749A3 (en) | Scaffold | |
DE69735207D1 (en) | NOVEL, FIBRINOGENIC BINDING PROTEIN, DERIVED FROM A COAGULASE NEGATIVE STAPHYLOKOKKUS | |
AU2003222717A1 (en) | Streptavidin-binding peptide | |
EP0783521B8 (en) | Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone | |
WO2002092758A8 (en) | Gastrokines and derived peptides including inhibitors | |
WO2000058465A3 (en) | Flint polypeptide analogs | |
WO2000032745A3 (en) | Homologous 28-kilodalton immunodominant protein genes of ehrlichia canis and uses thereof | |
EP0643728A4 (en) | Icam-related protein. | |
WO2002002148A3 (en) | Dual recombinant gene therapy compositions and methods of use | |
EP0801133A3 (en) | Hydroperoxide lyases | |
AU9629498A (en) | Method for the production of (poly)peptides by using truncated variants of the sv40 large t antigen with an intact n terminus | |
CA2235471A1 (en) | Dna encoding a plasminogen activating protein |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 10477527 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2450470 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003507238 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002756264 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2002756264 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |