WO2003003986A3 - Parathyroid hormone antibodies and related methods - Google Patents

Parathyroid hormone antibodies and related methods Download PDF

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Publication number
WO2003003986A3
WO2003003986A3 PCT/US2002/021356 US0221356W WO03003986A3 WO 2003003986 A3 WO2003003986 A3 WO 2003003986A3 US 0221356 W US0221356 W US 0221356W WO 03003986 A3 WO03003986 A3 WO 03003986A3
Authority
WO
WIPO (PCT)
Prior art keywords
parathyroid hormone
related methods
antibodies
hormone antibodies
methods
Prior art date
Application number
PCT/US2002/021356
Other languages
French (fr)
Other versions
WO2003003986A2 (en
Inventor
James Scott Hutchison
Original Assignee
Quest Diagnostics Invest Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25409386&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003003986(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Quest Diagnostics Invest Inc filed Critical Quest Diagnostics Invest Inc
Priority to EP02752184A priority Critical patent/EP1455821B1/en
Priority to AT02752184T priority patent/ATE490785T1/en
Priority to DE60238555T priority patent/DE60238555D1/en
Priority to JP2003510000A priority patent/JP2004536831A/en
Priority to AU2002354806A priority patent/AU2002354806A1/en
Publication of WO2003003986A2 publication Critical patent/WO2003003986A2/en
Publication of WO2003003986A3 publication Critical patent/WO2003003986A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides

Abstract

Methods of preparing antibodies that recognize and bind three-dimensional epitopes of antigens are disclosed. The methods are particularly useful for preparing antibodies that bind the bioactive, three-dimensional amino terminus of parathyroid hormone. The antibodies so produced are used in diagnostic (Fig.1) and therapeutic applications.
PCT/US2002/021356 2001-07-03 2002-07-03 Parathyroid hormone antibodies and related methods WO2003003986A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP02752184A EP1455821B1 (en) 2001-07-03 2002-07-03 Parathyroid hormone antibodies and related methods
AT02752184T ATE490785T1 (en) 2001-07-03 2002-07-03 PARATHORMONE ANTIBODIES AND RELATED METHODS
DE60238555T DE60238555D1 (en) 2001-07-03 2002-07-03 PARATHORMONE ANTIBODIES AND ASSOCIATED METHODS
JP2003510000A JP2004536831A (en) 2001-07-03 2002-07-03 Parathyroid hormone antibodies and related methods
AU2002354806A AU2002354806A1 (en) 2001-07-03 2002-07-03 Parathyroid hormone antibodies and related methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/898,398 2001-07-03
US09/898,398 US20030082179A1 (en) 2001-07-03 2001-07-03 Parathyroid hormone antibodies and related methods

Publications (2)

Publication Number Publication Date
WO2003003986A2 WO2003003986A2 (en) 2003-01-16
WO2003003986A3 true WO2003003986A3 (en) 2004-07-01

Family

ID=25409386

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/021356 WO2003003986A2 (en) 2001-07-03 2002-07-03 Parathyroid hormone antibodies and related methods

Country Status (7)

Country Link
US (4) US20030082179A1 (en)
EP (1) EP1455821B1 (en)
JP (1) JP2004536831A (en)
AT (1) ATE490785T1 (en)
AU (1) AU2002354806A1 (en)
DE (1) DE60238555D1 (en)
WO (1) WO2003003986A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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US7820393B2 (en) * 1999-01-14 2010-10-26 Scantibodies Laboratory, Inc. Methods, kits and antibodies for detecting parathyroid hormone
US6689566B1 (en) * 1999-01-14 2004-02-10 Scantibodies Laboratory, Inc. Methods, kits, and antibodies for detecting parathyroid hormone
US7226749B2 (en) * 2000-12-05 2007-06-05 Zahradnik Richard J Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84
US7318925B2 (en) * 2003-08-08 2008-01-15 Amgen Fremont, Inc. Methods of use for antibodies against parathyroid hormone
ES2321088T3 (en) * 2003-08-08 2009-06-02 Amgen Fremont Inc. ANTIBODIES DIRECTED AGAINST THE PARTIROID HORMONE (PTH) AND USES OF THE SAME.
GB0329146D0 (en) * 2003-12-16 2004-01-21 Glaxosmithkline Biolog Sa Vaccine
US7959920B2 (en) * 2005-09-06 2011-06-14 Scantibodies Laboratory, Inc. Methods of making and using antibodies directed to parathyroid hormone
EP2133695A1 (en) * 2008-06-12 2009-12-16 Koninklijke Philips Electronics N.V. Parathyroid hormone assay
BR112012005331A2 (en) † 2009-09-14 2019-09-24 Koninl Philips Electronics Nv "Immunoassay for detecting an analyte in a sample, method for detecting analytes in a sample, biosensor device, and appropriate part kit for detecting an analyte in a sample"
KR101882533B1 (en) * 2010-08-31 2018-07-26 교와 메덱스 가부시키가이샤 Method for measuring fibroblast growth factor-23 and reagent therefor
EP2631247A1 (en) 2012-02-22 2013-08-28 Immundiagnostik AG Means and methods of measuring parathyroid hormone in patients suffering from oxidative stress
EP2775306B1 (en) 2013-03-08 2018-06-27 Immundiagnostik AG Non-oxidized, biological active parathyroid hormone determines mortality in hemodialysis patients
KR101949405B1 (en) * 2016-10-21 2019-02-18 이화여자대학교 산학협력단 Animal model having hypoparathyroidism and method for producing the same
CN107255726B (en) * 2017-08-02 2018-09-14 江苏省原子医学研究所 Quantitatively detect the fluorescence immune chromatography test paper and preparation method thereof of human parathyroid hormone
WO2019141791A1 (en) 2018-01-17 2019-07-25 Immundiagnostik Ag Biomarker predicting coronary artery disease
KR20210120009A (en) * 2019-01-11 2021-10-06 라디우스 헬쓰, 인코포레이티드 Methods for Detection of Neutralizing Antibodies to Parathyroid Hormone (PTH) and Parathyroid Hormone-Related Peptide (PTHRP) Analogs

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BROWN R.C. ET AL.: "Comparison of poly- and monoclonal antibodies as labels in a two-site immunochemiluminometric assay for intact parathyoid hormone", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 109, 1988, pages 139 - 144, XP002976114 *
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GAO P. ET AL.: "Measuring the biologically active or authentic whole parathyroid hormone (PTH) with a novel immunoradiometric assay without cross-reaction to the PTH(7-84) fragment", JOURNAL OF BONE AND MINERAL RESEARCH, vol. 14, no. SUPPL.1, September 1999 (1999-09-01), pages S446, XP002976115 *
JIN L. ET AL.: "Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 35, 1 September 2000 (2000-09-01), pages 27238 - 27244, XP002976117 *
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KURONEN I. ET AL.: "Hen egg yolk antibodies purified by antigen affinity under highly alkaline conditions provide new tools for diagnostics. Human intact parathyrin as a model antigen", EUR. J. OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY, vol. 35, no. 6, 1997, pages 435 - 440, XP009062059 *

Also Published As

Publication number Publication date
ATE490785T1 (en) 2010-12-15
AU2002354806A1 (en) 2003-01-21
EP1455821A4 (en) 2006-04-12
JP2004536831A (en) 2004-12-09
US20030082179A1 (en) 2003-05-01
US20050003493A1 (en) 2005-01-06
WO2003003986A2 (en) 2003-01-16
US20060286107A1 (en) 2006-12-21
EP1455821B1 (en) 2010-12-08
DE60238555D1 (en) 2011-01-20
US20060024772A1 (en) 2006-02-02
EP1455821A2 (en) 2004-09-15

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