WO2003005959A3 - Amphiphilic star-like macromolecules for drug delivery - Google Patents

Amphiphilic star-like macromolecules for drug delivery Download PDF

Info

Publication number
WO2003005959A3
WO2003005959A3 PCT/US2002/021923 US0221923W WO03005959A3 WO 2003005959 A3 WO2003005959 A3 WO 2003005959A3 US 0221923 W US0221923 W US 0221923W WO 03005959 A3 WO03005959 A3 WO 03005959A3
Authority
WO
WIPO (PCT)
Prior art keywords
macromolecules
drug delivery
amphiphilic star
amphiphilic
star
Prior art date
Application number
PCT/US2002/021923
Other languages
French (fr)
Other versions
WO2003005959A2 (en
Inventor
Kathryn E Uhrich
Lu Tian
Original Assignee
Univ Rutgers
Kathryn E Uhrich
Lu Tian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers, Kathryn E Uhrich, Lu Tian filed Critical Univ Rutgers
Priority to JP2003511768A priority Critical patent/JP2005509593A/en
Priority to CA002453216A priority patent/CA2453216A1/en
Priority to MXPA04000354A priority patent/MXPA04000354A/en
Priority to KR10-2004-7000291A priority patent/KR20040029359A/en
Priority to EP02773155A priority patent/EP1414784A2/en
Publication of WO2003005959A2 publication Critical patent/WO2003005959A2/en
Publication of WO2003005959A3 publication Critical patent/WO2003005959A3/en
Priority to US10/754,900 priority patent/US7262221B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The present invention provides polymeric compounds that can form micelles in solutions. These compounds have a hydrophobic, core that is coupled to a plurality of hydrophilic moieties.
PCT/US2002/021923 2001-07-12 2002-07-12 Amphiphilic star-like macromolecules for drug delivery WO2003005959A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2003511768A JP2005509593A (en) 2001-07-12 2002-07-12 Amphiphilic star-like polymers for drug delivery
CA002453216A CA2453216A1 (en) 2001-07-12 2002-07-12 Amphiphilic star-like macromolecules for drug delivery
MXPA04000354A MXPA04000354A (en) 2001-07-12 2002-07-12 Amphiphilic star-like macromolecules for drug delivery.
KR10-2004-7000291A KR20040029359A (en) 2001-07-12 2002-07-12 Amphiphilic Star-Like Macromolecules for Drug Delivery
EP02773155A EP1414784A2 (en) 2001-07-12 2002-07-12 Amphiphilic star-like macromolecules for drug delivery
US10/754,900 US7262221B2 (en) 2001-07-12 2004-01-09 Amphiphilic star-like macromolecules for drug delivery

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30496501P 2001-07-12 2001-07-12
US60/304,965 2001-07-12
US33331001P 2001-11-23 2001-11-23
US60/333,310 2001-11-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/754,900 Continuation US7262221B2 (en) 2001-07-12 2004-01-09 Amphiphilic star-like macromolecules for drug delivery

Publications (2)

Publication Number Publication Date
WO2003005959A2 WO2003005959A2 (en) 2003-01-23
WO2003005959A3 true WO2003005959A3 (en) 2003-10-09

Family

ID=26974329

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/021923 WO2003005959A2 (en) 2001-07-12 2002-07-12 Amphiphilic star-like macromolecules for drug delivery

Country Status (7)

Country Link
US (1) US7262221B2 (en)
EP (1) EP1414784A2 (en)
JP (1) JP2005509593A (en)
KR (1) KR20040029359A (en)
CA (1) CA2453216A1 (en)
MX (1) MXPA04000354A (en)
WO (1) WO2003005959A2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486214B1 (en) * 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
CN1735418A (en) 2002-06-07 2006-02-15 拉特格斯州立大学 Micelle assemblies
EP1734936B1 (en) * 2004-01-30 2014-09-10 Rutgers, The State University Amphiphilic star-like or scoprion-like macromolecules, various compositions and uses thereof
US20050180922A1 (en) * 2004-02-12 2005-08-18 Discher Dennis E. Block co-polymer worm micelles and methods of use therefor
US7618778B2 (en) 2004-06-02 2009-11-17 Kaufman Joseph C Producing, cataloging and classifying sequence tags
US20120269886A1 (en) 2004-12-22 2012-10-25 Nitto Denko Corporation Therapeutic agent for pulmonary fibrosis
PT2730277T (en) 2004-12-22 2020-04-21 Nitto Denko Corp Drug carrier and drug carrier kit for inhibiting fibrosis
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
TWI407971B (en) 2007-03-30 2013-09-11 Nitto Denko Corp Cancer cells and tumor-related fibroblasts
US20090069740A1 (en) * 2007-09-07 2009-03-12 Polyplus Battery Company Protected donor electrodes for electro-transport drug delivery
JP2010539245A (en) 2007-09-14 2010-12-16 日東電工株式会社 Drug carrier
WO2009039505A1 (en) * 2007-09-20 2009-03-26 Rutgers, The State University Of New Jersey Compositions and methods for treating cardiovascular conditions
US9925162B2 (en) 2009-04-09 2018-03-27 The Regents Of The University Of Colorado Methods and compositions for inducing physiological hypertrophy
US8846850B2 (en) 2011-02-22 2014-09-30 Rutgers, The State University Of New Jersey Amphiphilic macromolecules for nucleic acid delivery
WO2012162307A2 (en) * 2011-05-23 2012-11-29 University Of Massachusetts Crosslinked polymer nano-assemblies and uses thereof
US9434681B2 (en) 2012-06-15 2016-09-06 Rutgers, The State University Of New Jersey Macromolecules for treating atherosclerosis
US9144579B2 (en) 2012-08-17 2015-09-29 Rutgers, The State University Of New Jersey Polyesters and methods of use thereof
US20140120057A1 (en) 2012-10-25 2014-05-01 Rutgers, The State University Of New Jersey Polymers and methods thereof for wound healing
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair
US9862672B2 (en) 2013-05-29 2018-01-09 Rutgers, The State University Of New Jersey Antioxidant-based poly(anhydride-esters)
US9399044B2 (en) 2014-05-28 2016-07-26 International Business Machines Corporation Antimicrobial cationic polyamines
WO2015191742A1 (en) 2014-06-13 2015-12-17 Rutgers, The State University Of New Jersey Process and intermediates for preparing poly(anhydride-esters)
WO2015195563A1 (en) 2014-06-16 2015-12-23 Rutgers, The State University Of New Jersey Antibacterial agents
US9630905B2 (en) 2014-09-08 2017-04-25 Rutgers, The State University Of New Jersey Amphiphilic macromolecules and methods of use thereof
WO2016164898A1 (en) 2015-04-10 2016-10-13 Rutgers, The State University Of New Jersey Kojic acid polymers
US10759740B2 (en) 2016-03-24 2020-09-01 Rutgers, The State University Of New Jersey Antibacterial agents
WO2018027227A1 (en) 2016-08-05 2018-02-08 Rutgers, The State University Of New Jersey Thermocleavable friction modifiers and methods thereof
WO2023146255A1 (en) * 2022-01-25 2023-08-03 주식회사 메디치바이오 Peptide transporter including hydrophobic structure that binds to albumin

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284233B1 (en) * 1998-09-17 2001-09-04 L'oreal Antiwrinkle composition comprising a combination of tightening polymers of synthetic and/or natural origin and of dendritic polyesters

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3235974A1 (en) * 1981-11-24 1983-06-01 Volkmar Dipl.-Ing. Merkel (FH), 8520 Erlangen DEVICE FOR REMOVAL OR FOR THE EXPANSION OF CONSTRAINTS IN BODY LIQUID LEADING VESSELS
US4597961A (en) * 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
DE3634016A1 (en) * 1986-04-17 1987-10-29 Lohmann Gmbh & Co Kg AREA-BASED THERAPEUTIC SYSTEM, METHOD FOR THE PRODUCTION THEREOF AND ITS USE
DE3743946A1 (en) * 1987-09-01 1989-03-09 Lohmann Gmbh & Co Kg DEVICE FOR DELIVERING NITROGLYCERIN TO THE SKIN, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
US6007845A (en) * 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US5830986A (en) * 1996-10-28 1998-11-03 Massachusetts Institute Of Technology Methods for the synthesis of functionalizable poly(ethylene oxide) star macromolecules

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284233B1 (en) * 1998-09-17 2001-09-04 L'oreal Antiwrinkle composition comprising a combination of tightening polymers of synthetic and/or natural origin and of dendritic polyesters

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JIANG ET AL.: "ACS symposium series (tailored polymeric materials for controlled delivery systems)", vol. 709, 8 October 1998 (1998-10-08), pages 117 - 124, XP002965924 *

Also Published As

Publication number Publication date
MXPA04000354A (en) 2004-07-23
KR20040029359A (en) 2004-04-06
EP1414784A2 (en) 2004-05-06
CA2453216A1 (en) 2003-01-23
WO2003005959A2 (en) 2003-01-23
US7262221B2 (en) 2007-08-28
US20040198641A1 (en) 2004-10-07
JP2005509593A (en) 2005-04-14

Similar Documents

Publication Publication Date Title
WO2003005959A3 (en) Amphiphilic star-like macromolecules for drug delivery
WO2002000194A3 (en) Polymeric micelle compositions
WO2002070438A3 (en) Compositions for delivering bisphosphonates
AU2002239324A1 (en) Biodegradable mixed polymeric micelles for drug delivery
WO2005044221A3 (en) Solid active ingredient formulation
MXPA03006775A (en) Pharmaceutical formulation.
HK1050526A1 (en) New a-amino acid compounds, a process for their preparation and pharmaceutical compositions containing them.
AU2002334684A1 (en) Systems, methods and apparatuses for manufacturing dosage forms
WO2001089479A3 (en) Sustained release pharmaceutical compositions for parenteral administration of hydrophilic compounds
WO2000040203A3 (en) Polymeric delivery agents and delivery agent compounds
AU2001276627A1 (en) Drug containing polymeric micelles
WO2003043586A3 (en) Compositions for sustained action product delivery
WO2001062299A3 (en) Water-soluble polymer conjugates of artelinic acid
AU2001238386A1 (en) Medication delivery devices
HK1050357A1 (en) New-amino acid sulphonyl compounds, a process for their preparation and pharmaceutical compositions containing them.
ZA200301813B (en) Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them.
WO2002051385A8 (en) Solid dispersions of nitrate active principles
MY130332A (en) Pharmaceutical formulation comprising iota-carrageenan and at least one neutral gelling polymer
AU2002238855A1 (en) N-phenylarylsulfonamide compound, drug containing the compound as active ingredient, intermediate for the compound, and processes for producing the same
DE60143363D1 (en) PHARMACEUTICAL COMPOSITIONS THAT PROMOTE THE IMMUNOGENICITY OF WEAK IMMUNOGENIC ANTIGENES
WO2002003962A3 (en) Drug delivery system for poorly water soluble drugs
ZA200402729B (en) Pharmaceutical formulation comprising (R) -bicalutamide.
WO2003041656A3 (en) Soluble drug extended release system
ZA200100565B (en) Benzenesulfonamide compounds, a process for their preparation and pharmaceutical compositions containing them.
CA2402708A1 (en) Torasemide-containing pharmaceutical preparations

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 10754900

Country of ref document: US

Ref document number: 2453216

Country of ref document: CA

Ref document number: 2002337650

Country of ref document: AU

Ref document number: 1020047000291

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: PA/a/2004/000354

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2003511768

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2002773155

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 20028179625

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 2002773155

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642