WO2003005989A3 - Granulates containing liposoluble substances and a process for the preparation thereof - Google Patents

Granulates containing liposoluble substances and a process for the preparation thereof Download PDF

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Publication number
WO2003005989A3
WO2003005989A3 PCT/EP2002/007636 EP0207636W WO03005989A3 WO 2003005989 A3 WO2003005989 A3 WO 2003005989A3 EP 0207636 W EP0207636 W EP 0207636W WO 03005989 A3 WO03005989 A3 WO 03005989A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
granulates
water
substances
granulates containing
Prior art date
Application number
PCT/EP2002/007636
Other languages
French (fr)
Other versions
WO2003005989A2 (en
Inventor
Alberto Reiner
Original Assignee
Apr Applied Pharma Res Sa
Fidia Farmaceutici
Ipsen Spa
Alberto Reiner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MXPA04000211A priority Critical patent/MXPA04000211A/en
Application filed by Apr Applied Pharma Res Sa, Fidia Farmaceutici, Ipsen Spa, Alberto Reiner filed Critical Apr Applied Pharma Res Sa
Priority to AU2002328866A priority patent/AU2002328866B2/en
Priority to KR1020047000280A priority patent/KR100877628B1/en
Priority to JP2003511797A priority patent/JP2004536118A/en
Priority to BR0211081-4A priority patent/BR0211081A/en
Priority to CA2452386A priority patent/CA2452386C/en
Priority to IL15934602A priority patent/IL159346A0/en
Priority to US10/258,004 priority patent/US7615547B2/en
Priority to NZ530473A priority patent/NZ530473A/en
Publication of WO2003005989A2 publication Critical patent/WO2003005989A2/en
Publication of WO2003005989A3 publication Critical patent/WO2003005989A3/en
Priority to NO20040043A priority patent/NO20040043L/en
Priority to HR20040010A priority patent/HRP20040010A2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Edible Oils And Fats (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process is described for the preparation of granulates that contain liposoluble and hydrophobic substances, preferably steroidal substances, and that exhibit rapid and excellent water-dispersibility. The process comprises: a) the dispersion of substance (A) in water in the presence of a surfactant (B), b) the incorporation of a water-soluble polyhydroxylated solid excipient (C) in the aqueous dispersion until a granulable pasty mass is obtained and c) the granulation of the mass. The granulates so obtained are suitable for the preparation, at the time of use, of stable and homogeneous aqueous suspensions that are used for nutritional, cosmetic or, preferably, pharmaceutical purposes.
PCT/EP2002/007636 2001-07-11 2002-07-09 Granulates containing liposoluble substances and a process for the preparation thereof WO2003005989A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CA2452386A CA2452386C (en) 2001-07-11 2002-07-09 Granulates containing liposoluble substances and a process for the preparation thereof
AU2002328866A AU2002328866B2 (en) 2001-07-11 2002-07-09 Granulates containing liposoluble substances and a process for the preparation thereof
KR1020047000280A KR100877628B1 (en) 2001-07-11 2002-07-09 Granulates containing liposoluble substances and a process for the preparation thereof
JP2003511797A JP2004536118A (en) 2001-07-11 2002-07-09 Granules containing fat-soluble substances and their preparation
BR0211081-4A BR0211081A (en) 2001-07-11 2002-07-09 Process for the preparation of granules, granules, pharmaceutical composition, and process for the preparation of aqueous dispersion
MXPA04000211A MXPA04000211A (en) 2001-07-11 2002-07-09 Granulates containing liposoluble substances and a process for the preparation thereof.
IL15934602A IL159346A0 (en) 2001-07-11 2002-07-09 Granulates containing liposoluble substances and a process for the preparation thereof
US10/258,004 US7615547B2 (en) 2001-07-11 2002-07-09 Granulates containing liposoluble substances and a process for the preparation thereof
NZ530473A NZ530473A (en) 2001-07-11 2002-07-09 Granulates containing liposoluble substances and a process for the preparation thereof
NO20040043A NO20040043L (en) 2001-07-11 2004-01-06 Granules containing fat-soluble compounds and a process for their preparation
HR20040010A HRP20040010A2 (en) 2001-07-11 2004-01-07 Granulates containing liposoluble substances and a process for the preparation thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01202657A EP1275377B1 (en) 2001-07-11 2001-07-11 Granulates containing liposoluble substances and process of preparation thereof
EP01202657.1 2001-07-11

Publications (2)

Publication Number Publication Date
WO2003005989A2 WO2003005989A2 (en) 2003-01-23
WO2003005989A3 true WO2003005989A3 (en) 2003-05-01

Family

ID=8180628

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/007636 WO2003005989A2 (en) 2001-07-11 2002-07-09 Granulates containing liposoluble substances and a process for the preparation thereof

Country Status (21)

Country Link
US (1) US7615547B2 (en)
EP (1) EP1275377B1 (en)
JP (1) JP2004536118A (en)
KR (1) KR100877628B1 (en)
AT (1) ATE243028T1 (en)
AU (1) AU2002328866B2 (en)
BR (1) BR0211081A (en)
CA (1) CA2452386C (en)
DE (1) DE60100389T2 (en)
DK (1) DK1275377T3 (en)
ES (1) ES2199202T3 (en)
HR (1) HRP20040010A2 (en)
IL (1) IL159346A0 (en)
MX (1) MXPA04000211A (en)
NO (1) NO20040043L (en)
NZ (1) NZ530473A (en)
PL (1) PL204963B1 (en)
PT (1) PT1275377E (en)
RU (1) RU2288704C2 (en)
WO (1) WO2003005989A2 (en)
ZA (1) ZA200309680B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050080486A1 (en) 2000-11-29 2005-04-14 Fallin T. Wade Facet joint replacement
US6579319B2 (en) 2000-11-29 2003-06-17 Medicinelodge, Inc. Facet joint replacement
US7753937B2 (en) 2003-12-10 2010-07-13 Facet Solutions Inc. Linked bilateral spinal facet implants and methods of use
CA2630304C (en) 2005-12-09 2012-04-10 Teva Pharmaceutical Industries Ltd. Aqueous dispersions and solutions of difficult to dissolve compounds and methods of their preparation
ES2496166T3 (en) * 2006-12-22 2014-09-18 Yuhan Corporation Solid dispersion containing revaprazan and its preparation process
EP3702442A1 (en) * 2011-12-22 2020-09-02 Life Technologies Corporation Cell culture media and methods
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
BR112018070199A2 (en) 2016-04-01 2019-01-29 Therapeuticsmd Inc pharmaceutical composition of steroid hormone
EP3641726A1 (en) * 2017-06-23 2020-04-29 MedCan Pharma A/S Cannabinoid pouch
CN108309933A (en) * 2018-03-19 2018-07-24 青岛国海生物制药有限公司 A kind of oral megestrol acetate nanosuspension and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814175A (en) * 1986-03-21 1989-03-21 Schering Aktiengesellschaft Nifedipine combination preparation
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US6028065A (en) * 1998-04-20 2000-02-22 Pharmaceutical Resources, Inc. Flocculated suspension of megestrol acetate
EP1008354A1 (en) * 1996-12-25 2000-06-14 Yamanouchi Pharmaceutical Co. Ltd. Immediately disintegrable medicinal compositions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0449232A (en) 1990-06-15 1992-02-18 Fujisawa Pharmaceut Co Ltd Composition of suspension or suspension and preparation therefrom
US5338732A (en) 1991-06-18 1994-08-16 Bristol-Myers Squibb Company Megestrol acetate formulation
US5395627A (en) * 1992-09-04 1995-03-07 Akzo N.V. Pharmaceutical granulate
FR2702968B1 (en) 1993-03-23 1995-06-23 Lafon Labor Process for the preparation of particles containing an active ingredient by extrusion and lyophilization.
BR9407728A (en) 1993-10-01 1997-02-12 Syntex Inc Oral suspensions of high doses of microfenolate mofetil
US5976570A (en) * 1993-12-21 1999-11-02 Applied Analytical Industries, Inc. Method for preparing low dose pharmaceutical products
FR2730163B1 (en) 1995-02-03 1997-04-04 Jouveinal Lab NOVEL PHARMACEUTICAL COMPOSITION CONTAINING TRIMEBUTINE AND PROCESS FOR THE PREPARATION THEREOF
US20020028248A1 (en) 1996-03-14 2002-03-07 Takayuki Tsukada Rapid-release microdispersible ecadotril preparation
DE19637082A1 (en) * 1996-09-12 1998-03-19 Boehringer Mannheim Gmbh Rapidly disintegrating pellets
ID29270A (en) 1998-11-20 2001-08-16 Rtp Pharma Inc MICRO PARTICLES THAT ARE STABILIZED BY PHOSPHOLIPIDS THAT CAN SPREAD
US6316029B1 (en) * 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814175A (en) * 1986-03-21 1989-03-21 Schering Aktiengesellschaft Nifedipine combination preparation
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
EP1008354A1 (en) * 1996-12-25 2000-06-14 Yamanouchi Pharmaceutical Co. Ltd. Immediately disintegrable medicinal compositions
US6028065A (en) * 1998-04-20 2000-02-22 Pharmaceutical Resources, Inc. Flocculated suspension of megestrol acetate

Also Published As

Publication number Publication date
CA2452386A1 (en) 2003-01-23
EP1275377A1 (en) 2003-01-15
WO2003005989A2 (en) 2003-01-23
BR0211081A (en) 2004-12-14
EP1275377B1 (en) 2003-06-18
CA2452386C (en) 2011-01-18
KR100877628B1 (en) 2009-01-07
PL369294A1 (en) 2005-04-18
PL204963B1 (en) 2010-02-26
JP2004536118A (en) 2004-12-02
RU2004103853A (en) 2005-03-27
DE60100389D1 (en) 2003-07-24
MXPA04000211A (en) 2005-03-07
DE60100389T2 (en) 2004-05-19
ZA200309680B (en) 2004-12-22
HRP20040010B1 (en) 2007-01-31
NO20040043L (en) 2004-01-06
US20040009232A1 (en) 2004-01-15
PT1275377E (en) 2003-11-28
AU2002328866B2 (en) 2007-02-15
IL159346A0 (en) 2004-06-01
NZ530473A (en) 2006-02-24
HRP20040010A2 (en) 2004-06-30
ATE243028T1 (en) 2003-07-15
KR20040018440A (en) 2004-03-03
US7615547B2 (en) 2009-11-10
ES2199202T3 (en) 2004-02-16
RU2288704C2 (en) 2006-12-10
DK1275377T3 (en) 2003-10-06

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