WO2003007854A1 - Device for inserting fill material particles into body cavities - Google Patents
Device for inserting fill material particles into body cavities Download PDFInfo
- Publication number
- WO2003007854A1 WO2003007854A1 PCT/US2001/022837 US0122837W WO03007854A1 WO 2003007854 A1 WO2003007854 A1 WO 2003007854A1 US 0122837 W US0122837 W US 0122837W WO 03007854 A1 WO03007854 A1 WO 03007854A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chamber
- reservoir
- injection cylinder
- fluid
- hollow
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4601—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2/4611—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of spinal prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/441—Joints for the spine, e.g. vertebrae, spinal discs made of inflatable pockets or chambers filled with fluid, e.g. with hydrogel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30242—Three-dimensional shapes spherical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30581—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid
- A61F2002/30588—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid filled with solid particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2002/4625—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use
- A61F2002/4627—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use with linear motion along or rotating motion about the instrument axis or the implantation direction, e.g. telescopic, along a guiding rod, screwing inside the instrument
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0071—Three-dimensional shapes spherical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
Definitions
- This invention relates to a medical instrument for filling a cavity formed within bone, a spinal disk, or a fixation device inserted therein, with biocompatible beads. More specifically, the present invention is directed to a vibratory tool having a reservoir of biocompatible material in fluid communication with a proximal end of a tubular injection cylinder, the injection cylinder and reservoir are vibrated to cause the material to pass from the reservoir into the proximal end of the injection cylinder.
- the vibratory action of the device and gravity allow the material to pass through the injection cylinder to its distal end and be deposited into a delivery site.
- the vibratory action of the injection cylinder causes the distal end of the cylinder to gently tap the deposited material thereby compacting the material within the delivery site.
- the unique construction and vibratory action of the present device prevents fill material from plugging the device during use and provides for a consistent flow of fill material into the delivery site. Description of the Related Art
- Bioceramic compounds and other types of fill material such as bone may be used as a fill material in the treatment of certain orthopaedic conditions; including fractures, non-unions, tumors, and cysts and as an adjunct to certain fusion procedures. In general, these conditions involve filling a cavity that has been created by the pathology itself or by the action of the surgeon during removal of the pathology.
- the cavity may be filled by the placement of a block of fill material or by the gradual addition of granules of fill material such as bioceramic beads, crushed bone or a combination thereof.
- a variety of different types of support and/or joining devices may be inserted into the cavity. These devices may be filled with the fill or graft material, as opposed to directly filing the cavity therewith.
- Devices such as those used in spinal fixation are well known in the art. Such devices may include apparatuses which are inserted into hollowed out portions of a spinal disk or vertebrae. For example, U.S.
- a damaged disc is reamed out and an expandable fabric bag is inserted into the cavity thus formed.
- Bone graft material is then inserted into the bag to fill and expand the bag such that the filled bag will take the place of the reamed out disc. Over time, the material within the bag will cause a fusion of the adjacent vertebrae.
- the bag filling is through an opening which is closed off after filling.
- Another device and method for stabilizing a spinal motion segment is described in co-pending U.S. Provisional App. No.
- a band of fabric or mesh is inserted into a reamed out cavity within a disk or other spinal body.
- the fabric of the band may be structured to allow a bone graft fill tool to penetrate the band, without causing it damage, and deposit fill material into the area defined by the band and surrounding tissue.
- These and other devices are intended to provide support to the spinal segment which they are being inserted into and to encourage fusion of the surrounding spinal bodies through the device.
- a key aspect to such devices is the proper placement and compaction of bone graft material into the site through which bone growth and eventual fusion is to take place.
- the cavity or device may be filled with material in a variety of different manners.
- Manual filling such as by insertion by hand of one or more chunks of fill material may not provide for ideal filling and compaction characteristics which may be essential to encouraging proper bone growth and fusion.
- the use of granular material in gradually filling the cavity, or a device inserted therein has the advantage of allowing filling through a smaller entrance portal.
- by gradually filling the cavity or device with granular fill material allows the cavity to be filled in a more uniform and complete manner.
- granular material such as ceramic granules tend to jam within injection tubes and tend to break apart and pulverize when injection and/or impaction forces are vigorously applied.
- broken or pulverized granules of bioceramic compounds contain fine dust particles that have been shown to inhibit bone growth.
- the granules may exist in a variety of shapes and sizes, such as, for example amorphous chunks or solid geometric shapes.
- spherical shaped beads provide several potential advantages over other granular shapes. Notably, spherical beads may provide maximal and consistent inter-granule porosity and improved flowability.
- spherical granules are known to jam and break apart during the injection procedure. Therefore, there is a need for a new method of granule injection that is easier, faster, and produces less jamming and granule breakage.
- the present invention is directed to a method and apparatus which provides for improved filling and compaction of bone graft material within a hollowed portion of a bone, spinal segment or a fixation device positioned therein.
- the present invention is directed to a filling instrument that directs one granule or bead to drop into a tube from a bead reservoir, upon dropping a bead into the tube, the tube and reservoir are pneumatically actuated to pop back up to unblock the granules therein, which in turn allows another bead or granule to drop into the tube in repeating cycles.
- the present device agitates the granules at each stroke so they fill up the tube.
- the up and down motion of the tube and reservoir also provides for compaction of the beads at the distal end of the tube which may compact the beads into the chamber or spinal fixation device being filled.
- the present invention allows the surgeon to fill body cavities more easily and completely, with less damage to granules, and through a very small entrance portal.
- the invention also provides a means to compact the granular mass, thereby improving the fill density and the stability of the granular pack.
- the invention provides for a bead reservoir that is submitted to vibratory energy that encourages the bead pack to flow into a hollow, tubular injection cylinder. Pneumatic, hydraulic, or other mechanical forces then cause the injection cylinder to oscillate along its longitudinal axis, while the beads are gently pushed into the cavity by a combination of frictional forces against the cylinder walls and the pull of gravity.
- the distal tip of the oscillating cavity gently taps the top of the bead pack, thereby forcing the beads into a more densely packed construct.
- one application of the invention is in the field of spinal surgery. Surgeons often attempt to fill certain spaces within the spine with bone or bone substitute materials, such as bioceramic material. The filled spaces then provide mechanical support and the proper milieu for bone ingrowth. The local spinal anatomy restricts safe access to certain internal spinal areas. Therefore, surgeons are often required to operate through very small entry portals.
- the present invention provides the surgeon with a reliable and effective device suitable for filling cavities deep within the spine, e.g. the interbody or intra-vertebral spaces.
- interbody fusion One particularly common spinal procedure is known as an interbody fusion.
- the surgeon attempts to fill the gap between two opposing vertebrae with a material and/or device that supports load and encourages bony ingrowth.
- Such devices include, but are not limited to, those described in U.S.
- the present device may be inserted through very small diameter tubes.
- this invention allows the surgeon to fill the interbody space through a portal substantially smaller than currently required for many procedures.
- Another area where the present invention may be of use would be in procedures known as vertebra-plasties or kypho-plasties, wherein the surgeon attempts to fill the area occupied by a so-called "compression fracture" of the vertebral body.
- the present invention could be used to fill this area through the narrow confines of the vertebral pedicle or through a small (about 3-10 mm) hole in the side or front of the vertebral body.
- use of the invention would reasonably reduce risk and complications compared to other procedures that require a larger exposure, as in the case of the placement of large bioceramic blocks.
- FIG. 1 is a perspective view of an embodiment of the invention
- FIG. 2 is a longitudinal sectional view of the embodiment of the invention shown in FIG. 1;
- FIG. 3 is an enlarged view of the angled opening slot joining the reservoir and the injection cylinder of the embodiment of the invention shown in FIG. 1 ;
- FIG. 4 is a perspective view of an embodiment of the invention as shown in its intended environment of use;
- FIG. 5 is a perspective view of an embodiment of the invention as shown in its intended environment of use;
- FIG. 6 is an exploded view of an embodiment of the invention;
- FIG. 7 is a detailed sectional view of portions of the housing of an embodiment of the invention.
- FIG. 8 is a block diagram illustrating the use of an embodiment of the invention.
- the filler instrument 10 has three primary portions: a central housing 12, a tubular injection cylinder or needle 14 and a reservoir 16.
- the needle 14 defines a hollow needle chamber or passage 20 which includes a proximal opening 22 at proximal end 26 and a distal opening 24 at distal end 28.
- the needle chamber 20 has a diameter sufficient to allow passage of a bioceramic bead or other particle of material 40 to pass therethrough in a single-file line or individually.
- the needle passage 20 and openings 22 and 24 will be approximately 0.5 mm to 5 mm in diameter
- the proximal opening 22 of needle 14 is in fluid communication with the reservoir 16.
- the reservoir may contain the fill material 40 such as bioceramic beads or other materials.
- the individual particles of material 40 are sized to be able to enter the proximal opening on a one-at-a-time basis and pass through the passage 20 in a single file line when the device 10 is activated.
- the central housing 12 defines a central passage or chamber 18 (as may best be seen in FIG. 6) through which the needle 14 may travel longitudinally therein.
- the proximal end 26 extends proximally beyond the housing 12 and passage 18 and is engaged to the reservoir 16.
- the reservoir 16 is defined by a reservoir housing 32,
- the reservoir housing 32 is engaged to the proximal end 26 of the needle 14 by a mounting collar 30.
- the mounting collar 30 employs one or more fastening members 34 to retain the proximal end 26 of the needle 14 therein.
- the fastening members 34 may be any type of fastener such as a screw, bolt, clip, etc.
- the mounting collar 30 may be engaged to the reservoir housing 32 by any of a variety of mechanisms. For example: the collar 30 and reservoir housing 32 may be opposingly threaded to allow the collar to be screwed into the reservoir housing 32, the collar 30 may be sized to fittingly engage the reservoir housing 32, the collar 30 may snap-fit into the reservoir housing, etc.
- the collar 30 includes an angled opening slot 42.
- the slot 42 is designed to allow beads to pass into the proximal opening 22 of the needle chamber 20 on a one-at-a-time basis such as is depicted in FIG. 2 and 4.
- the unique configuration of the opening slot 42 helps to prevent beads or other fill material from blocking the proximal opening 22 as well as prevent multiple beads or particles from plugging the needle chamber 20.
- the present device provides a user with a significant degree of control for placement of the beads in a delivery site, such as is illustrated in FIGs. 4-5.
- the reservoir housing 32 defines a reservoir chamber 36 which may be filled in- whole or in-part by a predetermined number or volume of fill material 40.
- the reservoir housing 32 may be at least partially transparent to allow a user to see the material 40 within the reservoir chamber 36.
- the reservoir housing 32 may also include volume indicators or markings so that the volume of material 40 remaining within the chamber 36 may be readily determined at any time.
- the fill material 40 may be comprised of bone graft material, bioceramic beads, crushed bone, and/or other types of biocompatible fill material.
- the reservoir housing also includes a reservoir plug or seal 38 which may be readily removed from the reservoir housing 32 to allow the fill material 40 to be inserted therein, and may be engaged to the reservoir housing 32 to prevent spillage of the fill material 40 therefrom.
- the seal 38 When secured to the reservoir housing 32, the seal 38 also acts to prevent the introduction of contaminants into the reservoir housing 32.
- the needle 14 extends from the reservoir 16 into the passage 18 of the central housing 12. Prior to entering the passage 18, the needle 14 passes through a proximal valve assembly 50, which provides a sliding valve seal 55 between the needle 14 and central housing 12.
- the proximal valve assembly may comprise a nut, ring or other type of retaining member 52 which is secured to a proximal valve receiving member 54 of the housing 12.
- the retaining member 52 and receiving member 54 may be reversibly threaded to allow the retaining member 52 to be threaded onto the receiving member 54, or they may be otherwise constructed to provide removable engagement therebetween.
- the retaining member 52 includes an inner radial lip 58 which defines an opening through which needle 14 is passed.
- the radial lip 58 provides a surface upon which an o-ring 56 may be positioned.
- the o-ring 56 is sandwiched between the radial lip 58 and the receiving member 54, there by providing a first or proximal sliding valve seal 55 between the housing 12 and the needle 14.
- the proximal seal assembly 50 defines the proximal end of a piston chamber 60.
- the piston chamber includes a fluid entrance port 62 which is connected to a fluid line 64 and source 44 shown in FIG. 8.
- the fluid source may be hydraulic, pneumatic, or any other means for providing liquid or air based pressure into the chamber 60.
- the piston chamber 60 includes a piston member 66 which extends outward from the needle 14 to the inner wall 68 of the chamber 60.
- the piston member 66 may be integral with the needle 14 or may be a separate apparatus through which the needle 14 is passed through and sealed therein.
- the piston member 66 includes a groove or notch 70 about its circumference 72.
- the notch 70 provides a space in which a piston o-ring 74 is placed.
- the piston o-ring 74 extends beyond the piston member 66 to contact the wall 68.
- the presence of the piston o-ring 74 between the piston member 66 and the wall 68 effectively provides a second or distal sliding valve seal 75 between the needle 14 and the housing 12.
- a fluid is injected into the piston chamber 60 from fluid line 64, fluid pressure will build within the chamber and press against the piston member 66.
- the arrangement of the first and second sliding seals 55 and 75 respectively allow the building pressure to move the piston member 66, and thus the needle 14, longitudinally in the distal direction.
- the distal movement of the piston member 66 and needle 14 is limited by the presence of a break or stop 78.
- the stop 78 shall be discussed in greater detail below.
- the housing 12 defines a biasing chamber 80.
- the biasing chamber 80 contains a biasing member or return spring 82 which is biased against the piston member 66 and a distal retaining collar 84.
- the distal retaining collar 84 may include one or more retaining projections 88 which project outwardly therefrom.
- the retaining projections 88 are received into a corresponding number of receiving channels 86 positioned in the housing 12, as is shown in FIG. 1.
- the arrangement of retaining projections 88 and receiving channels 86 provides the device 10 with the capacity to readily remove the retaining collar 84 thereby providing access to the various components discussed above contained within the housing 12.
- any variety of affixing means may be used to removably engage the distal retaining collar 84 to the housing 12.
- Such means may include, but are not limited to, screws and appropriately positioned holes, snap fit engagement of the collar 84 and housing 12, respectively reversed threads to allow the collar 84 to be threadingly received into the housing 12, etc.
- the distal retaining collar 84 includes a proximally extending stop 78, shown in FIG. 6.
- the stop 78 is constructed and arranged to limit the distance the piston member 66 can move when subjected to fluid pressure as discussed.
- the area between the distal retaining collar 84 and the piston member 66 defines the biasing chamber 80.
- the biasing member 82 When the pressure is released in this manner, the biasing member 82 has sufficient force to push the piston member 66 proximally to its original at rest position or until fluid pressure is sufficient to once again overcome the biasing force supplied to the piston member 66 from the biasing member 82, subsequent to which the piston will again begin moving distally to repeat the cycle.
- the wall 82 In order to allow for any compression of the biasing member 82, the wall
- vent hole 90 which allows air to travel out of the biasing chamber 80 during compression of the biasing member 82 and back therein during its expansion.
- the movement of the needle and reservoir may be varied depending on the rate which fluid is injected into the chamber 60.
- the rate may be selectively controlled by a pressure switch, toggle, button, knob, lever, or other controller device 48 connected to the device 10 and/or fluid source 44, such as is illustrated in FIG. 8.
- the controller 48 is a foot pedal which is operatively engaged to the fluid source 44 or line 64.
- reciprocation of the needle 14 and reservoir 16 functions, in-part, to vibrate or agitate the reservoir 16 and the fill material 40 located therein.
- the vibration of the reservoir 16 ensures that only individual particles of fill material 40 are accepted into the slot 42 and eventually the needle chamber 20. If multiple particles somehow manage to enter the slot 42 simultaneously, or the slot 42, and/or needle chamber 20 become jammed with particles of fill material 40, the vibration of the reservoir 16 and needle 14 is sufficient to dislodge the particles and/or blockage.
- the vibratory action of needle 14 and reservoir 16, when coupled with gravity ensures that the individual fill particles 40 which enter the needle chamber 20 will travel through its length to be deposited at the deposit site 96 as shown in FIGs. 4 and 5.
- an adjustable depth guide 92 may be disposed about the needle 14, such as is shown in FIG. 5.
- the depth guide 92 is effectively a hollow tube or sheath through which the needle 14 passes. In the embodiment shown, the needle 14 does not contact the depth guide 92. However, the depth guide 92 may be in intermittent or constant contact with the needle 14.
- depth guide 92 may be adjustable to provide the operating surgeon or technician with the ability to set the length of the needle 14 which may enter into the operating site 96 during reciprocation of the needle 14.
- the proximal end 98 of the depth guide 92 is threadingly engaged to the distal retaining collar 84 or other portion of the housing 12. By rotating the depth guide 92 about the threads 94, the depth guide 92 may be extended or retracted relative to the needle 14. Alternatively, the depth guide 92 may be slidingly or otherwise adjustably engaged to the housing 12 or a portion thereof.
- a contact member 100 which is sized to engage the opening or area of tissue adjacent to the opening of the operation site 96.
- the contact member may be integral with the depth guide 92 or may be permanently or removably attached thereto by a snap-fit, threading, sliding, or any other suitable attachment means or methods.
- Contact member 100 may be constructed from any material suitable for use in a surgical device. It is preferable however, that contact member 100 be constructed from one or more material which may have vibration absorbing properties such as rubber, silicon or other vibration dampening materials.
- sheath 92 as well as other portions of device 10 may include, or be constructed at least partially from vibration absorbing materials.
- the shape and size of the contact member 100 are such that the contact member may be placed against and supported by the tissue surrounding the opening of 5 the operation site 96. When placed about the operation site 96 in such a manner, the contact member 100 provides a stable point of reference which the operating surgeon may use to determine, adjust and set the depth, or potential depth, of the needle 14 into the operating site 96.
- the depth of the needle 14 into the operation site 96 may be established with accuracy.
- the tapping and compacting action of the reciprocating needle 14 against the fill material 40 may be precisely controlled. Such control will allow an operator to control or avoid inadvertent fracture or other potential damage to the particles of fill material 40.
- any dependent claim which follows should be taken as alternatively written in a multiple dependent form from all prior claims which possess all antecedents referenced in such dependent claim if such multiple dependent format is an accepted format within the jurisdiction (e.g. each claim depending directly from claim 1 should be alternatively taken as depending from all previous claims).
- the following dependent claims should each be also taken as alternatively written in each singly dependent claim format which creates a dependency from a prior antecedent-possessing claim other than the specific claim listed in such dependent claim below (e.g. claim 3 may be taken as alternatively dependent from claim 2; claim 5 may be taken as alternatively dependent on claim 3; etc.).
Abstract
An instrument for filling cavities in a body, such as a cavity within a reamed out spinal disc, with beads includes a cyclical agitator that functions to prompt the introduction of one bead at a time through the fill tube to prevent clogging and to promote compaction within the cavity.
Description
Device for Inserting Fill Material Particles Into Body Cavities
CROSS-REFERENCE TO RELATED APPLICATIONS Not Applicable
BACKGROUND OF THE INVENTION Field of the Invention
This invention relates to a medical instrument for filling a cavity formed within bone, a spinal disk, or a fixation device inserted therein, with biocompatible beads. More specifically, the present invention is directed to a vibratory tool having a reservoir of biocompatible material in fluid communication with a proximal end of a tubular injection cylinder, the injection cylinder and reservoir are vibrated to cause the material to pass from the reservoir into the proximal end of the injection cylinder. The vibratory action of the device and gravity allow the material to pass through the injection cylinder to its distal end and be deposited into a delivery site. The vibratory action of the injection cylinder causes the distal end of the cylinder to gently tap the deposited material thereby compacting the material within the delivery site. The unique construction and vibratory action of the present device prevents fill material from plugging the device during use and provides for a consistent flow of fill material into the delivery site. Description of the Related Art
Bioceramic compounds and other types of fill material such as bone may be used as a fill material in the treatment of certain orthopaedic conditions; including fractures, non-unions, tumors, and cysts and as an adjunct to certain fusion procedures. In general, these conditions involve filling a cavity that has been created by the pathology itself or by the action of the surgeon during removal of the pathology.
The cavity may be filled by the placement of a block of fill material or by the gradual addition of granules of fill material such as bioceramic beads, crushed bone or a combination thereof. Alternatively, a variety of different types of support and/or joining devices may be inserted into the cavity. These devices may be filled with the fill or graft material, as opposed to directly filing the cavity therewith.
Devices such as those used in spinal fixation are well known in the art. Such devices may include apparatuses which are inserted into hollowed out portions of a spinal disk or vertebrae. For example, U.S. Patents 5,549,679 issued August 20, 1996 and 5,571,189 which issued November 5, 1996, both of which being incorporated in their entirety herein by reference, disclose an expandable fabric bag and method for stabilizing a spinal motion segment. In these patents, a damaged disc is reamed out and an expandable fabric bag is inserted into the cavity thus formed. Bone graft material is then inserted into the bag to fill and expand the bag such that the filled bag will take the place of the reamed out disc. Over time, the material within the bag will cause a fusion of the adjacent vertebrae. The bag filling is through an opening which is closed off after filling. Another device and method for stabilizing a spinal motion segment is described in co-pending U.S. Provisional App. No. 60/256014 filed December 15, 2000, the entire contents of which being incorporated herein by reference. In this Application a band of fabric or mesh is inserted into a reamed out cavity within a disk or other spinal body. The fabric of the band may be structured to allow a bone graft fill tool to penetrate the band, without causing it damage, and deposit fill material into the area defined by the band and surrounding tissue.
These and other devices are intended to provide support to the spinal segment which they are being inserted into and to encourage fusion of the surrounding spinal bodies through the device. A key aspect to such devices is the proper placement and compaction of bone graft material into the site through which bone growth and eventual fusion is to take place.
As indicated above the cavity or device may be filled with material in a variety of different manners. Manual filling such as by insertion by hand of one or more chunks of fill material may not provide for ideal filling and compaction characteristics which may be essential to encouraging proper bone growth and fusion. The use of granular material in gradually filling the cavity, or a device inserted therein has the advantage of allowing filling through a smaller entrance portal. In addition, by gradually filling the cavity or device with granular fill material allows the cavity to be filled in a more uniform and complete manner.
In use however, granular material such as ceramic granules tend to jam within injection tubes and tend to break apart and pulverize when injection and/or impaction forces are vigorously applied. Broken or pulverized granules of bioceramic compounds contain fine dust particles that have been shown to inhibit bone growth. The granules may exist in a variety of shapes and sizes, such as, for example amorphous chunks or solid geometric shapes. Of the various available granule shapes, spherical shaped beads provide several potential advantages over other granular shapes. Notably, spherical beads may provide maximal and consistent inter-granule porosity and improved flowability. However, even spherical granules are known to jam and break apart during the injection procedure. Therefore, there is a need for a new method of granule injection that is easier, faster, and produces less jamming and granule breakage.
Experiments have been conducted with various means to more efficiently and effectively introduce granular material into cavities. The goal of these experiments was to develop a novel means for improving spherical granule flow while minimizing the breakage of granules. As a result of these experiments the device of the present invention was constructed. The present device was determined to provide the best combination of flow efficiency and the least tendency toward granule breakage during the fill process. By utilizing the present invention for inserting bioceramic beads or other fill material into a body cavity, the invention may improve the care of patients with certain orthopaedic conditions.
The art described in this section is not intended to constitute an admission that any patent, publication or other information referred to herein is "prior art" with respect to this invention, unless specifically designated as such. In addition, this section should not be construed to mean that a search has been made or that no other pertinent information as defined in 37 C.F.R. § 1.56(a) exists.
The entire content of all of the patents listed within the present patent application are incorporated herein by reference.
BRIEF SUMMARY OF THE INVENTION
In light of the above, the present invention is directed to a method and apparatus which provides for improved filling and compaction of bone graft material within a hollowed portion of a bone, spinal segment or a fixation device positioned therein.
In at least one embodiment, the present invention is directed to a filling instrument that directs one granule or bead to drop into a tube from a bead reservoir, upon dropping a bead into the tube, the tube and reservoir are pneumatically actuated to pop back up to unblock the granules therein, which in turn allows another bead or granule to drop into the tube in repeating cycles. The present device agitates the granules at each stroke so they fill up the tube. The up and down motion of the tube and reservoir also provides for compaction of the beads at the distal end of the tube which may compact the beads into the chamber or spinal fixation device being filled.
The present invention allows the surgeon to fill body cavities more easily and completely, with less damage to granules, and through a very small entrance portal. The invention also provides a means to compact the granular mass, thereby improving the fill density and the stability of the granular pack.
The invention provides for a bead reservoir that is submitted to vibratory energy that encourages the bead pack to flow into a hollow, tubular injection cylinder. Pneumatic, hydraulic, or other mechanical forces then cause the injection cylinder to oscillate along its longitudinal axis, while the beads are gently pushed into the cavity by a combination of frictional forces against the cylinder walls and the pull of gravity.
Once the cavity is filled or nearly filled, the distal tip of the oscillating cavity gently taps the top of the bead pack, thereby forcing the beads into a more densely packed construct.
As indicated above, one application of the invention is in the field of spinal surgery. Surgeons often attempt to fill certain spaces within the spine with bone or bone substitute materials, such as bioceramic material. The filled spaces then provide mechanical support and the proper milieu for bone ingrowth. The local spinal anatomy restricts safe access to certain internal spinal areas. Therefore, surgeons are often required to operate through very small entry portals. The present invention provides the
surgeon with a reliable and effective device suitable for filling cavities deep within the spine, e.g. the interbody or intra-vertebral spaces.
One particularly common spinal procedure is known as an interbody fusion. In the interbody fusion procedure, the surgeon attempts to fill the gap between two opposing vertebrae with a material and/or device that supports load and encourages bony ingrowth. Such devices include, but are not limited to, those described in U.S.
5,489,308; U.S. 5,549,679; U.S. 5,571,189 and others.
As shall be made clear from the description below, in at least one embodiment of the invention, the present device may be inserted through very small diameter tubes. As a result, it is possible to fill the intervertebral space with little or no retraction of sensitive local nerves and vessels. For example, this invention allows the surgeon to fill the interbody space through a portal substantially smaller than currently required for many procedures.
Another area where the present invention may be of use would be in procedures known as vertebra-plasties or kypho-plasties, wherein the surgeon attempts to fill the area occupied by a so-called "compression fracture" of the vertebral body. The present invention could be used to fill this area through the narrow confines of the vertebral pedicle or through a small (about 3-10 mm) hole in the side or front of the vertebral body. As a result, use of the invention would reasonably reduce risk and complications compared to other procedures that require a larger exposure, as in the case of the placement of large bioceramic blocks.
BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS
A detailed description of the invention is hereafter described with specific reference being made to the drawings in which:
FIG. 1 is a perspective view of an embodiment of the invention; FIG. 2 is a longitudinal sectional view of the embodiment of the invention shown in FIG. 1;
FIG. 3 is an enlarged view of the angled opening slot joining the reservoir and the injection cylinder of the embodiment of the invention shown in FIG. 1 ;
FIG. 4 is a perspective view of an embodiment of the invention as shown in its intended environment of use;
FIG. 5 is a perspective view of an embodiment of the invention as shown in its intended environment of use; FIG. 6 is an exploded view of an embodiment of the invention;
FIG. 7 is a detailed sectional view of portions of the housing of an embodiment of the invention; and
FIG. 8 is a block diagram illustrating the use of an embodiment of the invention.
DETAILED DESCRIPTION OF THE INVENTION
With reference to the figures 1-8 wherein identical elements are numbered identically throughout, an embodiment of the inventive filler instrument, indicated generally at 10, is shown. In the embodiment shown, the filler instrument 10, has three primary portions: a central housing 12, a tubular injection cylinder or needle 14 and a reservoir 16.
As is shown in FIG. 2, the needle 14 defines a hollow needle chamber or passage 20 which includes a proximal opening 22 at proximal end 26 and a distal opening 24 at distal end 28. The needle chamber 20 has a diameter sufficient to allow passage of a bioceramic bead or other particle of material 40 to pass therethrough in a single-file line or individually.
Typically, the needle passage 20 and openings 22 and 24 will be approximately 0.5 mm to 5 mm in diameter The proximal opening 22 of needle 14 is in fluid communication with the reservoir 16. The reservoir may contain the fill material 40 such as bioceramic beads or other materials. The individual particles of material 40 are sized to be able to enter the proximal opening on a one-at-a-time basis and pass through the passage 20 in a single file line when the device 10 is activated.
The central housing 12, defines a central passage or chamber 18 (as may best be seen in FIG. 6) through which the needle 14 may travel longitudinally therein. The proximal end 26 extends proximally beyond the housing 12 and passage 18 and is engaged to the reservoir 16. The reservoir 16 is defined by a reservoir housing 32, The
reservoir housing 32 is engaged to the proximal end 26 of the needle 14 by a mounting collar 30. The mounting collar 30 employs one or more fastening members 34 to retain the proximal end 26 of the needle 14 therein. The fastening members 34 may be any type of fastener such as a screw, bolt, clip, etc. The mounting collar 30 may be engaged to the reservoir housing 32 by any of a variety of mechanisms. For example: the collar 30 and reservoir housing 32 may be opposingly threaded to allow the collar to be screwed into the reservoir housing 32, the collar 30 may be sized to fittingly engage the reservoir housing 32, the collar 30 may snap-fit into the reservoir housing, etc.
As may best be seen in FIG. 3, the collar 30 includes an angled opening slot 42. The slot 42 is designed to allow beads to pass into the proximal opening 22 of the needle chamber 20 on a one-at-a-time basis such as is depicted in FIG. 2 and 4. The unique configuration of the opening slot 42 helps to prevent beads or other fill material from blocking the proximal opening 22 as well as prevent multiple beads or particles from plugging the needle chamber 20. In addition, by providing a slot 42 which regulates bead flow into the needle chamber 20, the present device provides a user with a significant degree of control for placement of the beads in a delivery site, such as is illustrated in FIGs. 4-5.
Returning to FIG. 2, the reservoir housing 32 defines a reservoir chamber 36 which may be filled in- whole or in-part by a predetermined number or volume of fill material 40. The reservoir housing 32 may be at least partially transparent to allow a user to see the material 40 within the reservoir chamber 36. The reservoir housing 32 may also include volume indicators or markings so that the volume of material 40 remaining within the chamber 36 may be readily determined at any time.
As indicated above, the fill material 40 may be comprised of bone graft material, bioceramic beads, crushed bone, and/or other types of biocompatible fill material. The reservoir housing also includes a reservoir plug or seal 38 which may be readily removed from the reservoir housing 32 to allow the fill material 40 to be inserted therein, and may be engaged to the reservoir housing 32 to prevent spillage of the fill material 40 therefrom. When secured to the reservoir housing 32, the seal 38 also acts to prevent the introduction of contaminants into the reservoir housing 32.
The needle 14 extends from the reservoir 16 into the passage 18 of the central housing 12. Prior to entering the passage 18, the needle 14 passes through a proximal valve assembly 50, which provides a sliding valve seal 55 between the needle 14 and central housing 12. The proximal valve assembly may comprise a nut, ring or other type of retaining member 52 which is secured to a proximal valve receiving member 54 of the housing 12. The retaining member 52 and receiving member 54 may be reversibly threaded to allow the retaining member 52 to be threaded onto the receiving member 54, or they may be otherwise constructed to provide removable engagement therebetween. The retaining member 52 includes an inner radial lip 58 which defines an opening through which needle 14 is passed. The radial lip 58 provides a surface upon which an o-ring 56 may be positioned. When the retaining member 52 is screwed or otherwise fastened on to the receiving member 54, the o-ring 56 is sandwiched between the radial lip 58 and the receiving member 54, there by providing a first or proximal sliding valve seal 55 between the housing 12 and the needle 14.
As is best shown in FIG. 2, the proximal seal assembly 50 defines the proximal end of a piston chamber 60. The piston chamber includes a fluid entrance port 62 which is connected to a fluid line 64 and source 44 shown in FIG. 8. The fluid source may be hydraulic, pneumatic, or any other means for providing liquid or air based pressure into the chamber 60. Turning to the close-up view shown in FIG. 7, the piston chamber 60 includes a piston member 66 which extends outward from the needle 14 to the inner wall 68 of the chamber 60. The piston member 66 may be integral with the needle 14 or may be a separate apparatus through which the needle 14 is passed through and sealed therein. The piston member 66 includes a groove or notch 70 about its circumference 72. The notch 70 provides a space in which a piston o-ring 74 is placed. The piston o-ring 74 extends beyond the piston member 66 to contact the wall 68. The presence of the piston o-ring 74 between the piston member 66 and the wall 68, effectively provides a second or distal sliding valve seal 75 between the needle 14 and the housing 12.
Referring to FIG. 7, when a fluid is injected into the piston chamber 60 from fluid line 64, fluid pressure will build within the chamber and press against the piston member 66. The arrangement of the first and second sliding seals 55 and 75 respectively allow the building pressure to move the piston member 66, and thus the needle 14, longitudinally in the distal direction. The distal movement of the piston member 66 and needle 14 is limited by the presence of a break or stop 78. The stop 78 shall be discussed in greater detail below.
Below the piston chamber 60, the housing 12 defines a biasing chamber 80. The biasing chamber 80 contains a biasing member or return spring 82 which is biased against the piston member 66 and a distal retaining collar 84. As may best be seen in FIG. 6, the distal retaining collar 84 may include one or more retaining projections 88 which project outwardly therefrom. The retaining projections 88 are received into a corresponding number of receiving channels 86 positioned in the housing 12, as is shown in FIG. 1. The arrangement of retaining projections 88 and receiving channels 86 provides the device 10 with the capacity to readily remove the retaining collar 84 thereby providing access to the various components discussed above contained within the housing 12. Alternatively, any variety of affixing means may be used to removably engage the distal retaining collar 84 to the housing 12. Such means may include, but are not limited to, screws and appropriately positioned holes, snap fit engagement of the collar 84 and housing 12, respectively reversed threads to allow the collar 84 to be threadingly received into the housing 12, etc.
As indicated above, the distal retaining collar 84 includes a proximally extending stop 78, shown in FIG. 6. The stop 78 is constructed and arranged to limit the distance the piston member 66 can move when subjected to fluid pressure as discussed. The area between the distal retaining collar 84 and the piston member 66 defines the biasing chamber 80. When the piston member 66 is moved distally as a result of fluid pressure in the piston chamber 60, the biasing member 82 is compressed. After the biasing member 82 has moved to its full extent and is stopped by stop 78, the fluid pressure will continue to build until it is sufficient to break the seal of valve seals 55 and/or 75, thereby momentarily releasing the built up fluid pressure within the piston chamber 60. When the pressure is released in this manner, the biasing member 82 has
sufficient force to push the piston member 66 proximally to its original at rest position or until fluid pressure is sufficient to once again overcome the biasing force supplied to the piston member 66 from the biasing member 82, subsequent to which the piston will again begin moving distally to repeat the cycle. In order to allow for any compression of the biasing member 82, the wall
68 of the housing 12 includes a vent hole 90 which allows air to travel out of the biasing chamber 80 during compression of the biasing member 82 and back therein during its expansion.
The injection of fluid into the piston chamber 60 coupled with the resistance provided by biasing member 82, provides the device 10 with a needle 14 and reservoir 16 which moves in a longitudinally reciprocating motion relative to the housing 12. Such reciprocating motion is indicated by arrows 46 in FIG. 4
The movement of the needle and reservoir may be varied depending on the rate which fluid is injected into the chamber 60. The rate may be selectively controlled by a pressure switch, toggle, button, knob, lever, or other controller device 48 connected to the device 10 and/or fluid source 44, such as is illustrated in FIG. 8. Preferably, the controller 48 is a foot pedal which is operatively engaged to the fluid source 44 or line 64.
As may be seen in FIG. 2, reciprocation of the needle 14 and reservoir 16 functions, in-part, to vibrate or agitate the reservoir 16 and the fill material 40 located therein. The vibration of the reservoir 16 ensures that only individual particles of fill material 40 are accepted into the slot 42 and eventually the needle chamber 20. If multiple particles somehow manage to enter the slot 42 simultaneously, or the slot 42, and/or needle chamber 20 become jammed with particles of fill material 40, the vibration of the reservoir 16 and needle 14 is sufficient to dislodge the particles and/or blockage. The vibratory action of needle 14 and reservoir 16, when coupled with gravity ensures that the individual fill particles 40 which enter the needle chamber 20 will travel through its length to be deposited at the deposit site 96 as shown in FIGs. 4 and 5. In addition to providing a vibratory action to the reservoir 16 and needle
14, the cyclic movement of the device 10 also provides the distal end of the needle 14
with a controlled tapping action which when applied to deposited fill material 40 compacts the fill material 40 without breaking or otherwise degrading the particles. As a result the fill material can be deposited loosely or extremely tight within the deposit site as desired. In order to ensure that the hollow needle 14 does not enter into the operation site to an undesired depth, an adjustable depth guide 92 may be disposed about the needle 14, such as is shown in FIG. 5. The depth guide 92 is effectively a hollow tube or sheath through which the needle 14 passes. In the embodiment shown, the needle 14 does not contact the depth guide 92. However, the depth guide 92 may be in intermittent or constant contact with the needle 14. If the device is constructed in such a manner that the depth guide 92 and needle 14 may be in contact with one another, or are in contact with one another, a biocompatible lubricant may be applied to the internal surface of the depth guide 92 to ensure minimalization of friction created by the contact between the moving needle 14 and depth guide 92. As may be seen in FIG. 5, depth guide 92 may be adjustable to provide the operating surgeon or technician with the ability to set the length of the needle 14 which may enter into the operating site 96 during reciprocation of the needle 14. In the embodiment shown, the proximal end 98 of the depth guide 92 is threadingly engaged to the distal retaining collar 84 or other portion of the housing 12. By rotating the depth guide 92 about the threads 94, the depth guide 92 may be extended or retracted relative to the needle 14. Alternatively, the depth guide 92 may be slidingly or otherwise adjustably engaged to the housing 12 or a portion thereof.
At the distal end 102 of depth guide 92 there may be a contact member 100 which is sized to engage the opening or area of tissue adjacent to the opening of the operation site 96. The contact member may be integral with the depth guide 92 or may be permanently or removably attached thereto by a snap-fit, threading, sliding, or any other suitable attachment means or methods. Contact member 100 may be constructed from any material suitable for use in a surgical device. It is preferable however, that contact member 100 be constructed from one or more material which may have vibration absorbing properties such as rubber, silicon or other vibration dampening materials. In
addition to contact member 100, sheath 92 as well as other portions of device 10 may include, or be constructed at least partially from vibration absorbing materials.
The shape and size of the contact member 100 are such that the contact member may be placed against and supported by the tissue surrounding the opening of 5 the operation site 96. When placed about the operation site 96 in such a manner, the contact member 100 provides a stable point of reference which the operating surgeon may use to determine, adjust and set the depth, or potential depth, of the needle 14 into the operating site 96.
By providing the device 10 with a depth gauge 92 and contact member
10 100, the depth of the needle 14 into the operation site 96 may be established with accuracy. As a result, the tapping and compacting action of the reciprocating needle 14 against the fill material 40 may be precisely controlled. Such control will allow an operator to control or avoid inadvertent fracture or other potential damage to the particles of fill material 40. In addition, inadvertent contact with the tissue of the operating site 96
15 may also be reduced.
In addition to being directed to the specific combinations of features claimed below, the invention is also directed to embodiments having other combinations of the dependent features claimed below and other combinations of the features described above. 0 The above disclosure is intended to be illustrative and not exhaustive.
This description will suggest many variations and alternatives to one of ordinary skill in this art. All these alternatives and variations are intended to be included within the scope of the claims where the term "comprising" means "including, but not limited to". Those familiar with the art may recognize other equivalents to the specific embodiments 5 described herein which equivalents are also intended to be encompassed by the claims. Further, the particular features presented in the dependent claims can be combined with each other in other manners within the scope of the invention such that the invention should be recognized as also specifically directed to other embodiments having any other possible combination of the features of the dependent claims. For 0 instance, for purposes of claim publication, any dependent claim which follows should be taken as alternatively written in a multiple dependent form from all prior claims which
possess all antecedents referenced in such dependent claim if such multiple dependent format is an accepted format within the jurisdiction (e.g. each claim depending directly from claim 1 should be alternatively taken as depending from all previous claims). In jurisdictions where multiple dependent claim formats are restricted, the following dependent claims should each be also taken as alternatively written in each singly dependent claim format which creates a dependency from a prior antecedent-possessing claim other than the specific claim listed in such dependent claim below (e.g. claim 3 may be taken as alternatively dependent from claim 2; claim 5 may be taken as alternatively dependent on claim 3; etc.).
Claims
1. A device for inserting particles of fill material into a body cavity comprising: a reservoir, the reservoir defining a chamber, the chamber constructed and arranged to contain a predetermined volume of the particles of fill material, the reservoir having an opening at one end through which the particles may exit the chamber, the opening slot constructed and arranged to allow only one particle at a time to exit the chamber; an injection cylinder, the injection cylinder having a proximal end and a distal end, the proximal end being engaged to the reservoir, the injection cylinder defining a hollow chamber being open at both ends, the proximal end of the injection cylinder being coupled to the reservoir thereby defining a coupled assembly, the hollow chamber being in fluid communication with the opening, the hollow chamber sized to receive the particles from the opening and pass the particles therethrough; and a reciprocator device; the reciprocator device operatively engaged to at least a portion of the injection cylinder, the reciprocator device constructed and arranged to reciprocatingly move the coupled assembly thereby causing the particles of fill material to exit the chamber through the opening one particle at a time and pass the particles through the hollow chamber.
2. The device of claim 1 wherein the hollow chamber is sized to pass the particles one at a time therethrough.
3. The device of claim 1 wherein the hollow chamber is sized to pass the particles in a single file manner therethrough.
4. The device of claim 1 wherein the hollow chamber is sized to pass a plurality of the particles in a single file manner therethrough.
5. The device of claim 1 wherein the reciprocator device defines a longitudinally oriented hollow passage which extends therethrough, the injector cylinder having a piston member fixedly engaged thereto, the reciprocator device being constructed and arranged to reciprocatingly move the piston member between a first position and a second position within a first portion of the longitudinally oriented hollow passage.
6. The device of claim 5 wherein the piston member further comprises a slidable
5 piston seal, the slidable piston seal slidably sealing the piston member to the first portion of the longitudinally oriented hollow passage.
7. The device of claim 6 wherein the longitudinally oriented hollow passage further comprises a proximal sliding seal assembly, the proximal sliding seal assembly slidably
10 sealing the injection cylinder proximal to the piston member to a proximal opening of the first portion of the longitudinally oriented hollow passage.
8. The device of claim 7 wherein reciprocator device further comprises a fluid injection port, the fluid injection port being positioned proximal of the piston member
15 and providing fluid communication between the first portion of the longitudinally oriented hollow passage and a fluid source.
9. The device of claim 8 wherein the fluid source is constructed and arranged to selectively inject a fluid into the first portion of the longitudinally oriented hollow
20 passage through the fluid injection port, the fluid providing a sufficient pressure to move the piston member from the first position to the second position.
10. The device of claim 9 further comprising a biasing member, the biasing member being positioned in a second portion of the longitudinally oriented hollow passage
25 distally positioned relative to the first portion of the longitudinally oriented hollow passage, the biasing member being biasedly engaged between the piston member and a distal stop member, the biasing member exerting a sufficient biasing force to move the piston member from the second position to the first position.
30 11. The device of claim 10 wherein the distal stop member is engaged to a distal end of the reciprocator device, the distal stop member defining an opening, the opening having a diameter sized to slidingly pass the cylindrical injector therethrough, the opening having a diameter smaller than the piston member.
12. The device of claim 11 wherein the distal stop member is removably engaged to 5 the distal end of the reciprocator device.
13. The device of claim 12 wherein the distal stop member further comprises at least one engagement member, the at least one engagement member constructed and arranged to be removably engaged to a distal end of the reciprocator device.
10
14. The device of claim 13 wherein the distal end of the reciprocator device comprises at least one engagement channel, the at least one engagement channel constructed and arranged to removably receive the at least one engagement member.
15 15. The device of claim 9 wherein the fluid source is a fluid pump selected from the group consisting of a pneumatic pump, a hydraulic pump, and any combination thereof.
16. The device of claim 7 wherein the proximal sliding seal assembly is constructed and arranged to release fluid pressure from the first portion of the longitudinally oriented
20 hollow passage after the piston member is moved from the first position to the second position therein.
17. The device of claim 1 wherein the reservoir is transparent.
25 18. The device of claim 1 wherein the reservoir further comprises a retaining collar, the opening being integral with the retaining collar.
19. The device of claim 18 wherein the retaining collar is removably engaged to the reservoir chamber. 30
20. The device of claim 19 wherein the proximal end of the injection cylinder is engaged to the retaining collar.
21. The device of claim 20 wherein the proximal end of the injection cylinder is 5 removably engaged to the retaining collar.
22. The device of claim 21 wherein the retaining collar further comprises at least one fastening member, the at least one fastening member removably retaining the proximal end of the injection cylinder to the retaining collar.
10
23. The device of claim 1 wherein the reservoir defines a reservoir opening for inserting the fill material into the reservoir chamber.
24. The device of claim 23 further comprising a removable reservoir plug, the 15 removable plug constructed and arranged to be removably engaged to the reservoir opening.
25. The device of claim 1 wherein the hollow chamber has a diameter of about 0.5 to about 5 mm.
20
26. The device of claim 1 wherein the particles of fill material are selected from at least one member of the group consisting of bioceramic beads, bone graft material and any combination thereof.
25 27. The device of claim 9 further comprising a controller device, the controller device constructed and arranged to selectively control the flow of fluid from the fluid source into the first portion of the longitudinally oriented hollow passage.
28. The device of claim 1 further comprising a depth guide, the depth guide defining 30 a sheath, the sheath being disposed about at least a portion of the injection cylinder, a proximal end of the depth guide being engaged to at least a portion of the reciprocator device, whereby when the reciprocator device reciprocatingly moves the coupled assembly the depth guide remains substantially immobile relative to the injection cylinder. 5
29. The device of claim 28 wherein the depth guide is adjustably engaged to the at least a portion of the reciprocator device.
30. The device of claim 29 wherein the depth guide is threadingly engaged to the at 10 least a portion of the reciprocator device.
31. The device of claim 28 wherein the depth guide further comprises a distal end, the distal end having a contact member engaged thereto, the contact member constructed and arranged to be disposed about at least a portion of an opening of an operating site.
15
32. The device of claim 32 wherein the contact member is removably engaged to the distal end of the depth guide.
33. The device of claim 32 wherein the contact member is constructed at least 20 partially from a vibration absorbing material.
34. The device of claim 28 wherein the depth guide and the injection cylinder have a lubricant therebetween.
25 35. The device of claim 34 wherein the lubricant is biocompatible.
36. A device for inserting fill material into a body cavity comprising: a hollow injection cylinder, a reservoir for containing the fill material, and a central housing, 30 the hollow injection cylinder being in fluid communication with the reservoir, the central housing defining a passage which extends therethrough, the passage being disposed about the hollow injection cylinder, the hollow injection cylinder being longitudinally moveable within the passage, the hollow injection cylinder and the central housing having at least one sliding valve seal therebetween; at least a portion of the hollow injection cylinder having a piston member fixedly engaged thereto, the piston member having a first position and being moveable to a second position, a first portion of the passage defining a piston chamber, the piston chamber constructed and arranged to receive a predetermined quantity of fluid therein, the predetermined quantity of fluid exerting a distally acting force on the piston member; a second portion of the passage defining a biasing chamber, the biasing chamber having a biasing member disposed between the piston member and a distal surface, the biasing member exerting a proximally acting biasing force on the piston member; whereby, when the predetermined quantity of fluid is received into the chamber, the first distally acting force is sufficient to move the piston member in the distal direction from the first position to the second position, after the piston member is moved to the second position at least a portion of the predetermined quantity of fluid is released, thereinafter the proximally acting force is sufficient to return the piston member from the second position to the first position.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2001/022837 WO2003007854A1 (en) | 2001-07-20 | 2001-07-20 | Device for inserting fill material particles into body cavities |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2001/022837 WO2003007854A1 (en) | 2001-07-20 | 2001-07-20 | Device for inserting fill material particles into body cavities |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003007854A1 true WO2003007854A1 (en) | 2003-01-30 |
Family
ID=21742715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/022837 WO2003007854A1 (en) | 2001-07-20 | 2001-07-20 | Device for inserting fill material particles into body cavities |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2003007854A1 (en) |
Cited By (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004019815A3 (en) * | 2002-08-27 | 2004-06-24 | Sdgi Holdings Inc | Systems and methods for intravertebral reduction |
EP1464292A1 (en) * | 2003-03-31 | 2004-10-06 | DePuy Spine, Inc. | Remotely-activated vertebroplasty injection device |
WO2007090030A2 (en) * | 2006-01-30 | 2007-08-09 | Warsaw Orthopedic, Inc. | Instruments for implanting nucleus replacement material in an intervertebral disc nucleus space |
WO2008003962A1 (en) * | 2006-07-04 | 2008-01-10 | University Of Southampton | A method and apparatus for bone graft compaction |
US7666226B2 (en) | 2005-08-16 | 2010-02-23 | Benvenue Medical, Inc. | Spinal tissue distraction devices |
US7682400B2 (en) | 2004-06-10 | 2010-03-23 | Spinal Ventures, Llc | Non-soft tissue repair |
US7931689B2 (en) | 2000-02-28 | 2011-04-26 | Spineology Inc. | Method and apparatus for treating a vertebral body |
US8366773B2 (en) | 2005-08-16 | 2013-02-05 | Benvenue Medical, Inc. | Apparatus and method for treating bone |
US8454617B2 (en) | 2005-08-16 | 2013-06-04 | Benvenue Medical, Inc. | Devices for treating the spine |
US8535327B2 (en) | 2009-03-17 | 2013-09-17 | Benvenue Medical, Inc. | Delivery apparatus for use with implantable medical devices |
US8591583B2 (en) | 2005-08-16 | 2013-11-26 | Benvenue Medical, Inc. | Devices for treating the spine |
US8809418B2 (en) | 2004-03-21 | 2014-08-19 | DePuy Synthes Products, LLC | Methods, materials and apparatus for treating bone and other tissue |
US8814873B2 (en) | 2011-06-24 | 2014-08-26 | Benvenue Medical, Inc. | Devices and methods for treating bone tissue |
US8950929B2 (en) | 2006-10-19 | 2015-02-10 | DePuy Synthes Products, LLC | Fluid delivery system |
US8956368B2 (en) | 2003-06-17 | 2015-02-17 | DePuy Synthes Products, LLC | Methods, materials and apparatus for treating bone and other tissue |
US8992541B2 (en) | 2003-03-14 | 2015-03-31 | DePuy Synthes Products, LLC | Hydraulic device for the injection of bone cement in percutaneous vertebroplasty |
US9259696B2 (en) | 2005-11-22 | 2016-02-16 | DePuy Synthes Products, Inc. | Mixing apparatus having central and planetary mixing elements |
US9381024B2 (en) | 2005-07-31 | 2016-07-05 | DePuy Synthes Products, Inc. | Marked tools |
US9642932B2 (en) | 2006-09-14 | 2017-05-09 | DePuy Synthes Products, Inc. | Bone cement and methods of use thereof |
US9788963B2 (en) | 2003-02-14 | 2017-10-17 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US9918767B2 (en) | 2005-08-01 | 2018-03-20 | DePuy Synthes Products, Inc. | Temperature control system |
US10085783B2 (en) | 2013-03-14 | 2018-10-02 | Izi Medical Products, Llc | Devices and methods for treating bone tissue |
US10111697B2 (en) | 2003-09-26 | 2018-10-30 | DePuy Synthes Products, Inc. | Device for delivering viscous material |
US10888433B2 (en) | 2016-12-14 | 2021-01-12 | DePuy Synthes Products, Inc. | Intervertebral implant inserter and related methods |
US10940016B2 (en) | 2017-07-05 | 2021-03-09 | Medos International Sarl | Expandable intervertebral fusion cage |
US10966840B2 (en) | 2010-06-24 | 2021-04-06 | DePuy Synthes Products, Inc. | Enhanced cage insertion assembly |
US10973652B2 (en) | 2007-06-26 | 2021-04-13 | DePuy Synthes Products, Inc. | Highly lordosed fusion cage |
US11273050B2 (en) | 2006-12-07 | 2022-03-15 | DePuy Synthes Products, Inc. | Intervertebral implant |
US11344424B2 (en) | 2017-06-14 | 2022-05-31 | Medos International Sarl | Expandable intervertebral implant and related methods |
US11426290B2 (en) | 2015-03-06 | 2022-08-30 | DePuy Synthes Products, Inc. | Expandable intervertebral implant, system, kit and method |
US11426286B2 (en) | 2020-03-06 | 2022-08-30 | Eit Emerging Implant Technologies Gmbh | Expandable intervertebral implant |
US11446156B2 (en) | 2018-10-25 | 2022-09-20 | Medos International Sarl | Expandable intervertebral implant, inserter instrument, and related methods |
US11446155B2 (en) | 2017-05-08 | 2022-09-20 | Medos International Sarl | Expandable cage |
US11452607B2 (en) | 2010-10-11 | 2022-09-27 | DePuy Synthes Products, Inc. | Expandable interspinous process spacer implant |
US11497619B2 (en) | 2013-03-07 | 2022-11-15 | DePuy Synthes Products, Inc. | Intervertebral implant |
US11510788B2 (en) | 2016-06-28 | 2022-11-29 | Eit Emerging Implant Technologies Gmbh | Expandable, angularly adjustable intervertebral cages |
US11596522B2 (en) | 2016-06-28 | 2023-03-07 | Eit Emerging Implant Technologies Gmbh | Expandable and angularly adjustable intervertebral cages with articulating joint |
US11602438B2 (en) | 2008-04-05 | 2023-03-14 | DePuy Synthes Products, Inc. | Expandable intervertebral implant |
US11607321B2 (en) | 2009-12-10 | 2023-03-21 | DePuy Synthes Products, Inc. | Bellows-like expandable interbody fusion cage |
US11612491B2 (en) | 2009-03-30 | 2023-03-28 | DePuy Synthes Products, Inc. | Zero profile spinal fusion cage |
US11654033B2 (en) | 2010-06-29 | 2023-05-23 | DePuy Synthes Products, Inc. | Distractible intervertebral implant |
US11737881B2 (en) | 2008-01-17 | 2023-08-29 | DePuy Synthes Products, Inc. | Expandable intervertebral implant and associated method of manufacturing the same |
US11752009B2 (en) | 2021-04-06 | 2023-09-12 | Medos International Sarl | Expandable intervertebral fusion cage |
US11850160B2 (en) | 2021-03-26 | 2023-12-26 | Medos International Sarl | Expandable lordotic intervertebral fusion cage |
US11911287B2 (en) | 2010-06-24 | 2024-02-27 | DePuy Synthes Products, Inc. | Lateral spondylolisthesis reduction cage |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1223495B (en) * | 1956-08-24 | 1966-08-25 | Foundation Lab Inc | Device for subcutaneous implantation of hormone preparations u. Like. In animal bodies |
FR2287894A1 (en) * | 1974-10-15 | 1976-05-14 | Roussel Uclaf | Automatic pellet implanting device - for subcutaneous introduction of prods into animals |
EP0621020A1 (en) * | 1993-04-21 | 1994-10-26 | SULZER Medizinaltechnik AG | Intervertebral prosthesis and method of implanting such a prosthesis |
DE4409836A1 (en) * | 1994-03-22 | 1995-09-28 | Draenert Klaus | Device for the mechanical protection of an implant or graft when inserted into and / or remaining in a living body |
US5489308A (en) | 1989-07-06 | 1996-02-06 | Spine-Tech, Inc. | Spinal implant |
US5549679A (en) | 1994-05-20 | 1996-08-27 | Kuslich; Stephen D. | Expandable fabric implant for stabilizing the spinal motion segment |
-
2001
- 2001-07-20 WO PCT/US2001/022837 patent/WO2003007854A1/en active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1223495B (en) * | 1956-08-24 | 1966-08-25 | Foundation Lab Inc | Device for subcutaneous implantation of hormone preparations u. Like. In animal bodies |
FR2287894A1 (en) * | 1974-10-15 | 1976-05-14 | Roussel Uclaf | Automatic pellet implanting device - for subcutaneous introduction of prods into animals |
US5489308A (en) | 1989-07-06 | 1996-02-06 | Spine-Tech, Inc. | Spinal implant |
EP0621020A1 (en) * | 1993-04-21 | 1994-10-26 | SULZER Medizinaltechnik AG | Intervertebral prosthesis and method of implanting such a prosthesis |
DE4409836A1 (en) * | 1994-03-22 | 1995-09-28 | Draenert Klaus | Device for the mechanical protection of an implant or graft when inserted into and / or remaining in a living body |
US5549679A (en) | 1994-05-20 | 1996-08-27 | Kuslich; Stephen D. | Expandable fabric implant for stabilizing the spinal motion segment |
US5571189A (en) | 1994-05-20 | 1996-11-05 | Kuslich; Stephen D. | Expandable fabric implant for stabilizing the spinal motion segment |
Cited By (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7931689B2 (en) | 2000-02-28 | 2011-04-26 | Spineology Inc. | Method and apparatus for treating a vertebral body |
US7803188B2 (en) | 2002-08-27 | 2010-09-28 | Warsaw Orthopedic, Inc. | Systems and methods for intravertebral reduction |
WO2004019815A3 (en) * | 2002-08-27 | 2004-06-24 | Sdgi Holdings Inc | Systems and methods for intravertebral reduction |
US10376372B2 (en) | 2003-02-14 | 2019-08-13 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US10433971B2 (en) | 2003-02-14 | 2019-10-08 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US11096794B2 (en) | 2003-02-14 | 2021-08-24 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US10786361B2 (en) | 2003-02-14 | 2020-09-29 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US10639164B2 (en) | 2003-02-14 | 2020-05-05 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US10583013B2 (en) | 2003-02-14 | 2020-03-10 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US10085843B2 (en) | 2003-02-14 | 2018-10-02 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US10575959B2 (en) | 2003-02-14 | 2020-03-03 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US9814590B2 (en) | 2003-02-14 | 2017-11-14 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US11432938B2 (en) | 2003-02-14 | 2022-09-06 | DePuy Synthes Products, Inc. | In-situ intervertebral fusion device and method |
US10555817B2 (en) | 2003-02-14 | 2020-02-11 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US10492918B2 (en) | 2003-02-14 | 2019-12-03 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US9808351B2 (en) | 2003-02-14 | 2017-11-07 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US9814589B2 (en) | 2003-02-14 | 2017-11-14 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US10420651B2 (en) | 2003-02-14 | 2019-09-24 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US9925060B2 (en) | 2003-02-14 | 2018-03-27 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US10405986B2 (en) | 2003-02-14 | 2019-09-10 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US9788963B2 (en) | 2003-02-14 | 2017-10-17 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US11207187B2 (en) | 2003-02-14 | 2021-12-28 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US9801729B2 (en) | 2003-02-14 | 2017-10-31 | DePuy Synthes Products, Inc. | In-situ formed intervertebral fusion device and method |
US8992541B2 (en) | 2003-03-14 | 2015-03-31 | DePuy Synthes Products, LLC | Hydraulic device for the injection of bone cement in percutaneous vertebroplasty |
US9186194B2 (en) | 2003-03-14 | 2015-11-17 | DePuy Synthes Products, Inc. | Hydraulic device for the injection of bone cement in percutaneous vertebroplasty |
US10799278B2 (en) | 2003-03-14 | 2020-10-13 | DePuy Synthes Products, Inc. | Hydraulic device for the injection of bone cement in percutaneous vertebroplasty |
US9839460B2 (en) | 2003-03-31 | 2017-12-12 | DePuy Synthes Products, Inc. | Remotely-activated vertebroplasty injection device |
US8066713B2 (en) | 2003-03-31 | 2011-11-29 | Depuy Spine, Inc. | Remotely-activated vertebroplasty injection device |
US10485597B2 (en) | 2003-03-31 | 2019-11-26 | DePuy Synthes Products, Inc. | Remotely-activated vertebroplasty injection device |
EP1464292A1 (en) * | 2003-03-31 | 2004-10-06 | DePuy Spine, Inc. | Remotely-activated vertebroplasty injection device |
US8956368B2 (en) | 2003-06-17 | 2015-02-17 | DePuy Synthes Products, LLC | Methods, materials and apparatus for treating bone and other tissue |
US10039585B2 (en) | 2003-06-17 | 2018-08-07 | DePuy Synthes Products, Inc. | Methods, materials and apparatus for treating bone and other tissue |
US9504508B2 (en) | 2003-06-17 | 2016-11-29 | DePuy Synthes Products, Inc. | Methods, materials and apparatus for treating bone and other tissue |
US10111697B2 (en) | 2003-09-26 | 2018-10-30 | DePuy Synthes Products, Inc. | Device for delivering viscous material |
US8809418B2 (en) | 2004-03-21 | 2014-08-19 | DePuy Synthes Products, LLC | Methods, materials and apparatus for treating bone and other tissue |
US9750840B2 (en) | 2004-03-21 | 2017-09-05 | DePuy Synthes Products, Inc. | Methods, materials and apparatus for treating bone and other tissue |
US8734520B2 (en) | 2004-06-10 | 2014-05-27 | Spinal Ventures, Llc | Device and method for securing a fastener |
US9526539B2 (en) | 2004-06-10 | 2016-12-27 | Spinal Ventures, Llc | Non-soft tissue repair |
US7682400B2 (en) | 2004-06-10 | 2010-03-23 | Spinal Ventures, Llc | Non-soft tissue repair |
US9381024B2 (en) | 2005-07-31 | 2016-07-05 | DePuy Synthes Products, Inc. | Marked tools |
US9918767B2 (en) | 2005-08-01 | 2018-03-20 | DePuy Synthes Products, Inc. | Temperature control system |
US8882836B2 (en) | 2005-08-16 | 2014-11-11 | Benvenue Medical, Inc. | Apparatus and method for treating bone |
US7670375B2 (en) | 2005-08-16 | 2010-03-02 | Benvenue Medical, Inc. | Methods for limiting the movement of material introduced between layers of spinal tissue |
US9326866B2 (en) | 2005-08-16 | 2016-05-03 | Benvenue Medical, Inc. | Devices for treating the spine |
US7666226B2 (en) | 2005-08-16 | 2010-02-23 | Benvenue Medical, Inc. | Spinal tissue distraction devices |
US7666227B2 (en) | 2005-08-16 | 2010-02-23 | Benvenue Medical, Inc. | Devices for limiting the movement of material introduced between layers of spinal tissue |
US7670374B2 (en) | 2005-08-16 | 2010-03-02 | Benvenue Medical, Inc. | Methods of distracting tissue layers of the human spine |
US9259326B2 (en) | 2005-08-16 | 2016-02-16 | Benvenue Medical, Inc. | Spinal tissue distraction devices |
US9066808B2 (en) | 2005-08-16 | 2015-06-30 | Benvenue Medical, Inc. | Method of interdigitating flowable material with bone tissue |
US9788974B2 (en) | 2005-08-16 | 2017-10-17 | Benvenue Medical, Inc. | Spinal tissue distraction devices |
US9044338B2 (en) | 2005-08-16 | 2015-06-02 | Benvenue Medical, Inc. | Spinal tissue distraction devices |
US8979929B2 (en) | 2005-08-16 | 2015-03-17 | Benvenue Medical, Inc. | Spinal tissue distraction devices |
US8961609B2 (en) | 2005-08-16 | 2015-02-24 | Benvenue Medical, Inc. | Devices for distracting tissue layers of the human spine |
US7785368B2 (en) | 2005-08-16 | 2010-08-31 | Benvenue Medical, Inc. | Spinal tissue distraction devices |
US7955391B2 (en) | 2005-08-16 | 2011-06-07 | Benvenue Medical, Inc. | Methods for limiting the movement of material introduced between layers of spinal tissue |
US8808376B2 (en) | 2005-08-16 | 2014-08-19 | Benvenue Medical, Inc. | Intravertebral implants |
US8801787B2 (en) | 2005-08-16 | 2014-08-12 | Benvenue Medical, Inc. | Methods of distracting tissue layers of the human spine |
US10028840B2 (en) | 2005-08-16 | 2018-07-24 | Izi Medical Products, Llc | Spinal tissue distraction devices |
US8591583B2 (en) | 2005-08-16 | 2013-11-26 | Benvenue Medical, Inc. | Devices for treating the spine |
US8556978B2 (en) | 2005-08-16 | 2013-10-15 | Benvenue Medical, Inc. | Devices and methods for treating the vertebral body |
US7963993B2 (en) | 2005-08-16 | 2011-06-21 | Benvenue Medical, Inc. | Methods of distracting tissue layers of the human spine |
US7967865B2 (en) | 2005-08-16 | 2011-06-28 | Benvenue Medical, Inc. | Devices for limiting the movement of material introduced between layers of spinal tissue |
US7967864B2 (en) | 2005-08-16 | 2011-06-28 | Benvenue Medical, Inc. | Spinal tissue distraction devices |
US8057544B2 (en) | 2005-08-16 | 2011-11-15 | Benvenue Medical, Inc. | Methods of distracting tissue layers of the human spine |
US8454617B2 (en) | 2005-08-16 | 2013-06-04 | Benvenue Medical, Inc. | Devices for treating the spine |
US8366773B2 (en) | 2005-08-16 | 2013-02-05 | Benvenue Medical, Inc. | Apparatus and method for treating bone |
US10631906B2 (en) | 2005-11-22 | 2020-04-28 | DePuy Synthes Products, Inc. | Apparatus for transferring a viscous material |
US9259696B2 (en) | 2005-11-22 | 2016-02-16 | DePuy Synthes Products, Inc. | Mixing apparatus having central and planetary mixing elements |
WO2007090030A2 (en) * | 2006-01-30 | 2007-08-09 | Warsaw Orthopedic, Inc. | Instruments for implanting nucleus replacement material in an intervertebral disc nucleus space |
WO2007090030A3 (en) * | 2006-01-30 | 2008-04-10 | Warsaw Orthopedic Inc | Instruments for implanting nucleus replacement material in an intervertebral disc nucleus space |
WO2008003962A1 (en) * | 2006-07-04 | 2008-01-10 | University Of Southampton | A method and apparatus for bone graft compaction |
US10272174B2 (en) | 2006-09-14 | 2019-04-30 | DePuy Synthes Products, Inc. | Bone cement and methods of use thereof |
US9642932B2 (en) | 2006-09-14 | 2017-05-09 | DePuy Synthes Products, Inc. | Bone cement and methods of use thereof |
US10494158B2 (en) | 2006-10-19 | 2019-12-03 | DePuy Synthes Products, Inc. | Fluid delivery system |
US8950929B2 (en) | 2006-10-19 | 2015-02-10 | DePuy Synthes Products, LLC | Fluid delivery system |
US11273050B2 (en) | 2006-12-07 | 2022-03-15 | DePuy Synthes Products, Inc. | Intervertebral implant |
US11660206B2 (en) | 2006-12-07 | 2023-05-30 | DePuy Synthes Products, Inc. | Intervertebral implant |
US11642229B2 (en) | 2006-12-07 | 2023-05-09 | DePuy Synthes Products, Inc. | Intervertebral implant |
US11712345B2 (en) | 2006-12-07 | 2023-08-01 | DePuy Synthes Products, Inc. | Intervertebral implant |
US11497618B2 (en) | 2006-12-07 | 2022-11-15 | DePuy Synthes Products, Inc. | Intervertebral implant |
US11432942B2 (en) | 2006-12-07 | 2022-09-06 | DePuy Synthes Products, Inc. | Intervertebral implant |
US9642712B2 (en) | 2007-02-21 | 2017-05-09 | Benvenue Medical, Inc. | Methods for treating the spine |
US10575963B2 (en) | 2007-02-21 | 2020-03-03 | Benvenue Medical, Inc. | Devices for treating the spine |
US10285821B2 (en) | 2007-02-21 | 2019-05-14 | Benvenue Medical, Inc. | Devices for treating the spine |
US10426629B2 (en) | 2007-02-21 | 2019-10-01 | Benvenue Medical, Inc. | Devices for treating the spine |
US11622868B2 (en) | 2007-06-26 | 2023-04-11 | DePuy Synthes Products, Inc. | Highly lordosed fusion cage |
US10973652B2 (en) | 2007-06-26 | 2021-04-13 | DePuy Synthes Products, Inc. | Highly lordosed fusion cage |
US11737881B2 (en) | 2008-01-17 | 2023-08-29 | DePuy Synthes Products, Inc. | Expandable intervertebral implant and associated method of manufacturing the same |
US11602438B2 (en) | 2008-04-05 | 2023-03-14 | DePuy Synthes Products, Inc. | Expandable intervertebral implant |
US11707359B2 (en) | 2008-04-05 | 2023-07-25 | DePuy Synthes Products, Inc. | Expandable intervertebral implant |
US11617655B2 (en) | 2008-04-05 | 2023-04-04 | DePuy Synthes Products, Inc. | Expandable intervertebral implant |
US11712342B2 (en) | 2008-04-05 | 2023-08-01 | DePuy Synthes Products, Inc. | Expandable intervertebral implant |
US11712341B2 (en) | 2008-04-05 | 2023-08-01 | DePuy Synthes Products, Inc. | Expandable intervertebral implant |
US11701234B2 (en) | 2008-04-05 | 2023-07-18 | DePuy Synthes Products, Inc. | Expandable intervertebral implant |
US8535327B2 (en) | 2009-03-17 | 2013-09-17 | Benvenue Medical, Inc. | Delivery apparatus for use with implantable medical devices |
US11612491B2 (en) | 2009-03-30 | 2023-03-28 | DePuy Synthes Products, Inc. | Zero profile spinal fusion cage |
US11607321B2 (en) | 2009-12-10 | 2023-03-21 | DePuy Synthes Products, Inc. | Bellows-like expandable interbody fusion cage |
US10966840B2 (en) | 2010-06-24 | 2021-04-06 | DePuy Synthes Products, Inc. | Enhanced cage insertion assembly |
US11872139B2 (en) | 2010-06-24 | 2024-01-16 | DePuy Synthes Products, Inc. | Enhanced cage insertion assembly |
US11911287B2 (en) | 2010-06-24 | 2024-02-27 | DePuy Synthes Products, Inc. | Lateral spondylolisthesis reduction cage |
US11654033B2 (en) | 2010-06-29 | 2023-05-23 | DePuy Synthes Products, Inc. | Distractible intervertebral implant |
US11452607B2 (en) | 2010-10-11 | 2022-09-27 | DePuy Synthes Products, Inc. | Expandable interspinous process spacer implant |
US9314252B2 (en) | 2011-06-24 | 2016-04-19 | Benvenue Medical, Inc. | Devices and methods for treating bone tissue |
US8814873B2 (en) | 2011-06-24 | 2014-08-26 | Benvenue Medical, Inc. | Devices and methods for treating bone tissue |
US11497619B2 (en) | 2013-03-07 | 2022-11-15 | DePuy Synthes Products, Inc. | Intervertebral implant |
US11850164B2 (en) | 2013-03-07 | 2023-12-26 | DePuy Synthes Products, Inc. | Intervertebral implant |
US10085783B2 (en) | 2013-03-14 | 2018-10-02 | Izi Medical Products, Llc | Devices and methods for treating bone tissue |
US11426290B2 (en) | 2015-03-06 | 2022-08-30 | DePuy Synthes Products, Inc. | Expandable intervertebral implant, system, kit and method |
US11596522B2 (en) | 2016-06-28 | 2023-03-07 | Eit Emerging Implant Technologies Gmbh | Expandable and angularly adjustable intervertebral cages with articulating joint |
US11596523B2 (en) | 2016-06-28 | 2023-03-07 | Eit Emerging Implant Technologies Gmbh | Expandable and angularly adjustable articulating intervertebral cages |
US11510788B2 (en) | 2016-06-28 | 2022-11-29 | Eit Emerging Implant Technologies Gmbh | Expandable, angularly adjustable intervertebral cages |
US10888433B2 (en) | 2016-12-14 | 2021-01-12 | DePuy Synthes Products, Inc. | Intervertebral implant inserter and related methods |
US11446155B2 (en) | 2017-05-08 | 2022-09-20 | Medos International Sarl | Expandable cage |
US11344424B2 (en) | 2017-06-14 | 2022-05-31 | Medos International Sarl | Expandable intervertebral implant and related methods |
US10940016B2 (en) | 2017-07-05 | 2021-03-09 | Medos International Sarl | Expandable intervertebral fusion cage |
US11446156B2 (en) | 2018-10-25 | 2022-09-20 | Medos International Sarl | Expandable intervertebral implant, inserter instrument, and related methods |
US11426286B2 (en) | 2020-03-06 | 2022-08-30 | Eit Emerging Implant Technologies Gmbh | Expandable intervertebral implant |
US11806245B2 (en) | 2020-03-06 | 2023-11-07 | Eit Emerging Implant Technologies Gmbh | Expandable intervertebral implant |
US11850160B2 (en) | 2021-03-26 | 2023-12-26 | Medos International Sarl | Expandable lordotic intervertebral fusion cage |
US11752009B2 (en) | 2021-04-06 | 2023-09-12 | Medos International Sarl | Expandable intervertebral fusion cage |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6620162B2 (en) | Device for inserting fill material particles into body cavities | |
WO2003007854A1 (en) | Device for inserting fill material particles into body cavities | |
AU773220C (en) | Tools for injecting bone graft material | |
US11666455B2 (en) | Bone graft delivery devices, systems and kits | |
US8357169B2 (en) | System and method for delivering an agglomeration of solid beads and cement to the interior of a bone in order to form an implant within the bone | |
US10195053B2 (en) | Bone graft delivery system and method for using same | |
EP2108324B1 (en) | Device for producing a hardenable mass | |
US11660208B2 (en) | Bone graft delivery system and method for using same | |
US20160106551A1 (en) | Biological delivery system with adaptable fusion cage interface | |
AU2005215373A1 (en) | Surgical instrumentation and method for treatment of a spinal structure | |
US20230059830A1 (en) | Bone graft delivery systems and methods for using same | |
US20220304824A1 (en) | Bone graft delivery system and method for using same | |
EP2029038B1 (en) | System for delivering an agglomeration of solid beads and cement to the interior of a bone in order to form an implant within the bone | |
US10245159B1 (en) | Bone graft delivery system and method for using same | |
US20200146737A1 (en) | Method, composition, and apparatus for stabilization of vertebral bodies | |
EP3357459A1 (en) | Bone graft delivery device with positioning handle |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AU CA HU JP KR US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: JP |