WO2003015809A3 - Antimicrobial cationic peptides and formulations thereof - Google Patents

Antimicrobial cationic peptides and formulations thereof Download PDF

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Publication number
WO2003015809A3
WO2003015809A3 PCT/US2002/026525 US0226525W WO03015809A3 WO 2003015809 A3 WO2003015809 A3 WO 2003015809A3 US 0226525 W US0226525 W US 0226525W WO 03015809 A3 WO03015809 A3 WO 03015809A3
Authority
WO
WIPO (PCT)
Prior art keywords
formulations
antimicrobial cationic
cationic peptides
infections
antimicrobial
Prior art date
Application number
PCT/US2002/026525
Other languages
French (fr)
Other versions
WO2003015809A9 (en
WO2003015809A2 (en
Inventor
Timothy J Krieger
Patricia J Mcnicol
Janet R Fraser
Original Assignee
Micrologix Biotech Inc
Timothy J Krieger
Patricia J Mcnicol
Janet R Fraser
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micrologix Biotech Inc, Timothy J Krieger, Patricia J Mcnicol, Janet R Fraser filed Critical Micrologix Biotech Inc
Priority to AT02759416T priority Critical patent/ATE504308T1/en
Priority to CA2456477A priority patent/CA2456477C/en
Priority to EP02759416A priority patent/EP1469876B1/en
Priority to AU2002324752A priority patent/AU2002324752B2/en
Priority to DE60239707T priority patent/DE60239707D1/en
Priority to JP2003520767A priority patent/JP4932136B2/en
Publication of WO2003015809A2 publication Critical patent/WO2003015809A2/en
Publication of WO2003015809A3 publication Critical patent/WO2003015809A3/en
Publication of WO2003015809A9 publication Critical patent/WO2003015809A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Compositions and methods for making and using therapeutic formulations of antimicrobial cationic peptides are provided. The antimicrobial cationic peptide formulations may be used, for example, in the treatment of microorganism-caused infections, which infections may be systemic, such as a septicemia, or may be localized, such as in acne or an implanted or indwelling medical device.
PCT/US2002/026525 2001-08-21 2002-08-21 Antimicrobial cationic peptides and formulations thereof WO2003015809A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AT02759416T ATE504308T1 (en) 2001-08-21 2002-08-21 ANTIMICROBIAL CATIONIC PEPTIDES AND FORMULATIONS CONTAINING SAME
CA2456477A CA2456477C (en) 2001-08-21 2002-08-21 Antimicrobial cationic peptides and formulations thereof
EP02759416A EP1469876B1 (en) 2001-08-21 2002-08-21 Antimicrobial cationic peptides and formulations thereof
AU2002324752A AU2002324752B2 (en) 2001-08-21 2002-08-21 Antimicrobial cationic peptides and formulations thereof
DE60239707T DE60239707D1 (en) 2001-08-21 2002-08-21 ANTIMICROBIAL CATIONIC PEPTIDES AND FORMULATIONS CONTAINING THEM
JP2003520767A JP4932136B2 (en) 2001-08-21 2002-08-21 Antibacterial cationic peptides and formulations thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31423201P 2001-08-21 2001-08-21
US60/314,232 2001-08-21
US10/225,087 US6835536B2 (en) 2001-08-21 2002-08-20 Antimicrobial cationic peptides and formulations thereof
US10/225,087 2002-08-20

Publications (3)

Publication Number Publication Date
WO2003015809A2 WO2003015809A2 (en) 2003-02-27
WO2003015809A3 true WO2003015809A3 (en) 2004-03-18
WO2003015809A9 WO2003015809A9 (en) 2004-04-22

Family

ID=26919289

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/026525 WO2003015809A2 (en) 2001-08-21 2002-08-21 Antimicrobial cationic peptides and formulations thereof

Country Status (8)

Country Link
US (5) US6835536B2 (en)
EP (1) EP1469876B1 (en)
JP (3) JP4932136B2 (en)
AT (1) ATE504308T1 (en)
AU (1) AU2002324752B2 (en)
CA (1) CA2456477C (en)
DE (1) DE60239707D1 (en)
WO (1) WO2003015809A2 (en)

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CN110431150A (en) 2017-01-18 2019-11-08 威特拉公司 Antibody molecule-drug conjugates and application thereof
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WO2018160791A1 (en) 2017-03-03 2018-09-07 Massachusetts Institute Of Technology Antimicrobial constructs and uses thereof
SG11201909016TA (en) * 2017-04-06 2019-10-30 Amicrobe Inc Compositions and uses of locally-applied antimicrobial synthetic cationic polypeptide(s) with enhanced performance and safety
WO2020162582A1 (en) * 2019-02-08 2020-08-13 Maruho Co., Ltd. Methods of treating non-virally-induced cancers
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Also Published As

Publication number Publication date
US6835536B2 (en) 2004-12-28
US9227999B2 (en) 2016-01-05
DE60239707D1 (en) 2011-05-19
JP2015028082A (en) 2015-02-12
JP4932136B2 (en) 2012-05-16
CA2456477C (en) 2016-02-16
JP5684098B2 (en) 2015-03-11
US8466102B2 (en) 2013-06-18
EP1469876A2 (en) 2004-10-27
CA2456477A1 (en) 2003-02-27
EP1469876B1 (en) 2011-04-06
AU2002324752B2 (en) 2008-07-03
US20120202735A1 (en) 2012-08-09
US20130296227A1 (en) 2013-11-07
WO2003015809A9 (en) 2004-04-22
US8138144B2 (en) 2012-03-20
JP2005504769A (en) 2005-02-17
US20150087580A1 (en) 2015-03-26
JP2012041367A (en) 2012-03-01
ATE504308T1 (en) 2011-04-15
WO2003015809A2 (en) 2003-02-27
US20050049182A1 (en) 2005-03-03
US20030171281A1 (en) 2003-09-11
US8927487B2 (en) 2015-01-06

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