WO2003017947A3 - Spontaneous emulsions containing cyclosporine - Google Patents

Spontaneous emulsions containing cyclosporine Download PDF

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Publication number
WO2003017947A3
WO2003017947A3 PCT/US2002/027531 US0227531W WO03017947A3 WO 2003017947 A3 WO2003017947 A3 WO 2003017947A3 US 0227531 W US0227531 W US 0227531W WO 03017947 A3 WO03017947 A3 WO 03017947A3
Authority
WO
WIPO (PCT)
Prior art keywords
cyclosporine
emulsions containing
spontaneous
orally administered
containing cyclosporine
Prior art date
Application number
PCT/US2002/027531
Other languages
French (fr)
Other versions
WO2003017947A2 (en
Inventor
Kamel F Egbaria
Michael J Groves
Original Assignee
Morton Grove Pharmaceuticals I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morton Grove Pharmaceuticals I filed Critical Morton Grove Pharmaceuticals I
Priority to GB0405785A priority Critical patent/GB2395902A/en
Priority to CA002458448A priority patent/CA2458448A1/en
Priority to AU2002356137A priority patent/AU2002356137B2/en
Publication of WO2003017947A2 publication Critical patent/WO2003017947A2/en
Publication of WO2003017947A3 publication Critical patent/WO2003017947A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A pharmaceutical composition contains cyclosporine as the active ingredient. More specifically, the composition is an orally administered pharmaceutical formulation in the form of a spontaneous emulsion comprising cyclosporine, ethanol ethyl oleate and polyoxyethylene glycerol trioleate. A method for preparing an orally administered pharmaceutical composition involves first dissolving cyclosporine in ethanol. Polyoxyethylene glycerol trioleate and an oil component are then added, mixed and diluted in an aqueous media to form a spontaneous emulsion.
PCT/US2002/027531 2001-08-31 2002-08-29 Spontaneous emulsions containing cyclosporine WO2003017947A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB0405785A GB2395902A (en) 2001-08-31 2002-08-29 Spontaneous emulsions containing cyclosporine
CA002458448A CA2458448A1 (en) 2001-08-31 2002-08-29 Spontaneous emulsions containing cyclosporine
AU2002356137A AU2002356137B2 (en) 2001-08-31 2002-08-29 Spontaneous emulsions containing cyclosporine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/943,687 US6960563B2 (en) 2001-08-31 2001-08-31 Spontaneous emulsions containing cyclosporine
US09/943,687 2001-08-31

Publications (2)

Publication Number Publication Date
WO2003017947A2 WO2003017947A2 (en) 2003-03-06
WO2003017947A3 true WO2003017947A3 (en) 2004-01-29

Family

ID=25480095

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/027531 WO2003017947A2 (en) 2001-08-31 2002-08-29 Spontaneous emulsions containing cyclosporine

Country Status (5)

Country Link
US (1) US6960563B2 (en)
AU (1) AU2002356137B2 (en)
CA (1) CA2458448A1 (en)
GB (1) GB2395902A (en)
WO (1) WO2003017947A2 (en)

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Also Published As

Publication number Publication date
GB0405785D0 (en) 2004-04-21
CA2458448A1 (en) 2003-03-06
WO2003017947A2 (en) 2003-03-06
US20030049280A1 (en) 2003-03-13
US6960563B2 (en) 2005-11-01
GB2395902A (en) 2004-06-09
AU2002356137B2 (en) 2007-02-15

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