WO2003020324A3 - Methods for sterilizing preparations of digestive enzymes - Google Patents

Methods for sterilizing preparations of digestive enzymes Download PDF

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Publication number
WO2003020324A3
WO2003020324A3 PCT/US2002/027532 US0227532W WO03020324A3 WO 2003020324 A3 WO2003020324 A3 WO 2003020324A3 US 0227532 W US0227532 W US 0227532W WO 03020324 A3 WO03020324 A3 WO 03020324A3
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WO
WIPO (PCT)
Prior art keywords
digestive enzymes
methods
sterilizing preparations
preparations
sterilizing
Prior art date
Application number
PCT/US2002/027532
Other languages
French (fr)
Other versions
WO2003020324A2 (en
Inventor
Inc Clearant
David M Mann
Wilson H Burgess
William N Drohan
Martin J Macphee
Yuri Griko
Original Assignee
Inc Clearant
David M Mann
Wilson H Burgess
William N Drohan
Martin J Macphee
Yuri Griko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inc Clearant, David M Mann, Wilson H Burgess, William N Drohan, Martin J Macphee, Yuri Griko filed Critical Inc Clearant
Priority to AU2002329915A priority Critical patent/AU2002329915A1/en
Priority to JP2003524629A priority patent/JP4307255B2/en
Priority to EP02766169A priority patent/EP1429617A4/en
Publication of WO2003020324A2 publication Critical patent/WO2003020324A2/en
Publication of WO2003020324A3 publication Critical patent/WO2003020324A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/007—Particle radiation, e.g. electron-beam, alpha or beta radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0035—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0041—X-rays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0047—Ultraviolet radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0052—Visible light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/16—Emollients or protectives, e.g. against radiation
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation

Abstract

Methods are disclosed for sterilizing preparations of digestive enzymes to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. These methods involve sterilizing preparations of digestive enzymes, such as trypsin, -galactosidase and iduronate-2-sulfatase, with irradiation.
PCT/US2002/027532 2001-08-31 2002-08-30 Methods for sterilizing preparations of digestive enzymes WO2003020324A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002329915A AU2002329915A1 (en) 2001-08-31 2002-08-30 Methods for sterilizing preparations of digestive enzymes
JP2003524629A JP4307255B2 (en) 2001-08-31 2002-08-30 Method of disinfecting digestive enzyme preparation
EP02766169A EP1429617A4 (en) 2001-08-31 2002-08-30 Methods for sterilizing preparations of digestive enzymes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/942,938 2001-08-31
US09/942,938 US6749851B2 (en) 2001-08-31 2001-08-31 Methods for sterilizing preparations of digestive enzymes

Publications (2)

Publication Number Publication Date
WO2003020324A2 WO2003020324A2 (en) 2003-03-13
WO2003020324A3 true WO2003020324A3 (en) 2004-01-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/027532 WO2003020324A2 (en) 2001-08-31 2002-08-30 Methods for sterilizing preparations of digestive enzymes

Country Status (5)

Country Link
US (3) US6749851B2 (en)
EP (1) EP1429617A4 (en)
JP (1) JP4307255B2 (en)
AU (1) AU2002329915A1 (en)
WO (1) WO2003020324A2 (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458574B1 (en) * 1996-09-12 2002-10-01 Transkaryotic Therapies, Inc. Treatment of a α-galactosidase a deficiency
US6083725A (en) * 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
CA2343826C (en) 1998-09-21 2008-12-23 Howard E. Purdum Methods and apparatus for processing temperature sensitive materials
US6749851B2 (en) * 2001-08-31 2004-06-15 Clearant, Inc. Methods for sterilizing preparations of digestive enzymes
US7252799B2 (en) * 2001-08-31 2007-08-07 Clearant, Inc. Methods for sterilizing preparations containing albumin
US20110091353A1 (en) * 2001-09-24 2011-04-21 Wilson Burgess Methods for Sterilizing Tissue
US20030185702A1 (en) * 2002-02-01 2003-10-02 Wilson Burgess Methods for sterilizing tissue
US20030180181A1 (en) * 2002-02-01 2003-09-25 Teri Greib Methods for sterilizing tissue
US7731954B2 (en) 2002-04-24 2010-06-08 Insense Limited Wound dressings comprising hydrated hydrogels and enzymes
BR122017016940B8 (en) * 2002-04-25 2021-07-27 Transkaryotic Therapies Inc method for preparing a pharmaceutical composition comprising alpha-galactosidase a
GB0313217D0 (en) 2003-06-09 2003-07-16 Insense Ltd Improvements in or relating to skin dressings
CA2525758A1 (en) * 2003-06-09 2004-12-16 Insense Limited Method for stabilization of enzymes during exposure to sterilizing radiation
EP1557094A1 (en) * 2004-01-26 2005-07-27 Wageningen Centre for Food Sciences Improved semi-solid food products and methods for their production based on inhibiting amylase induced starch breakdown
PL1729797T3 (en) * 2004-03-22 2009-02-27 Abbott Laboratories Gmbh Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants
US20060270571A1 (en) * 2005-05-26 2006-11-30 Burke Peter A Deactivation of mineral encapsulated nanobacteria
CN101233229B (en) 2005-07-29 2013-05-01 雅培实验室有限公司 Processes for the manufacture of sterilized pancreatin powder
US9198871B2 (en) * 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US11266607B2 (en) * 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US20070134814A1 (en) * 2005-12-09 2007-06-14 Kajander E O Methods and compositions for the detection of calcifying nano-particles, identification and quantification of associated proteins thereon, and correlation to disease
US8131560B2 (en) 2006-02-15 2012-03-06 Genzyme Corporation Systems and methods for managing regulatory information
JP2007248175A (en) * 2006-03-15 2007-09-27 Sekisui Chem Co Ltd Blood examination container
EP1852443A1 (en) 2006-05-05 2007-11-07 Leukocare AG Biocompatible three dimensional matrix for the immobilization of biological substances
US10072256B2 (en) * 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
DE102006038629A1 (en) * 2006-08-17 2008-02-21 Dr. Suwelack Skin & Health Care Ag Stabilized active ingredient composition
US8580192B2 (en) 2006-10-31 2013-11-12 Ethicon, Inc. Sterilization of polymeric materials
DE102007044100A1 (en) * 2007-09-14 2009-03-19 Nordmark Arzneimittel Gmbh & Co. Kg Reduction of virus and microorganism load in a biological extract useful for producing e.g. medicaments, comprises providing a solid material containing biological extract in form of suspension and powder and irradiating the extract
DE202008003806U1 (en) * 2007-09-14 2009-02-12 Nordmark Arzneimittel Gmbh & Co. Kg Extract for the manufacture of pharmaceutical therapeutics and their use as food or food or dietary supplements
EP2058335B1 (en) * 2007-11-07 2020-06-24 Leukocare Ag Biocompatible three dimensional matrix for the immobilization of biological substances
US20090130063A1 (en) * 2007-11-15 2009-05-21 Solvay Pharmaceuticals Gmbh Process for separating and determining the viral load in a pancreatin sample
AU2011228744A1 (en) * 2010-03-19 2012-10-11 Aptalis Pharma Canada Inc. Beta-propiolactone for inactivation of viruses in pharmaceutical pancreatic enzyme preparations
GB201110339D0 (en) 2011-06-20 2011-08-03 Leeds Metropolitan University Method of decontamination and sterilisation
IL294717B2 (en) 2012-02-17 2023-08-01 Alcresta Inc Methods, compositions, and devices for supplying dietary fatty acid needs
IN2014DN09624A (en) * 2012-05-14 2015-07-31 Teijin Ltd
US20150147309A1 (en) * 2012-06-06 2015-05-28 Fondazione Telethon Allosteric chaperones and uses thereof
GB201508025D0 (en) 2015-05-11 2015-06-24 Ucl Business Plc Fabry disease gene therapy
EP3298139B1 (en) 2015-05-19 2021-09-15 Scientific Protein Laboratories LLC Method for reducing or inactivating viral and microbial content in the processes for the manufacture of pancreatin
US10258590B2 (en) 2015-10-14 2019-04-16 Alcresta Therapeutics, Inc. Enteral feeding device and related methods of use
CN115737790A (en) * 2016-03-28 2023-03-07 雅培制药股份有限公司 Enzyme compositions with reduced viral and microbial contamination
US11278603B2 (en) 2016-03-28 2022-03-22 Abbvie Inc. Enzyme compositions with reduced viral and microbial contamination
KR101813920B1 (en) * 2016-07-06 2018-01-04 넨시스(주) Sterilization method of pancreatin and manufacturing method of pancreatin using the same
US11045396B2 (en) 2017-08-17 2021-06-29 Alcresta Therapeutics, Inc. Devices and methods for the supplementation of a nutritional formula
EP3688153A1 (en) 2017-09-27 2020-08-05 Abbott Laboratories GmbH Enzyme compositions with reduced viral and microbial contamination
JP2019184612A (en) * 2018-04-13 2019-10-24 株式会社島津製作所 Analysis method and analyzer
BR112020021358A2 (en) * 2018-05-18 2021-01-19 Qiagen Sciences Llc METHODS OF PROTECTING THE BIOLOGICAL ACTIVITY OF A BIOLOGICALLY ACTIVE MOLECULE, OF A MULTIPLE OF MOLECULES OF A BIOLOGICALLY ACTIVE MOLECULE, AND OF THE BIOLOGICAL ACTIVITY OF A BIOLOGICALLY ACTIVE PROTEIN

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962038A (en) * 1972-03-09 1976-06-08 Director Of National Food Research Institute Preparation of water-insoluble enzymes
US5002776A (en) * 1983-12-22 1991-03-26 Elan Corporation, Plc Controlled absorption diltiazem formulations
JPH0898688A (en) * 1991-02-25 1996-04-16 Takeda Chem Ind Ltd Stabilization of bromelain solution
US5510122A (en) * 1994-09-28 1996-04-23 The Research Foundation Of State University Of New York Preparation and use of whole saliva

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE23195E (en) 1950-02-07 Preserving
US2832689A (en) 1952-01-24 1958-04-29 Research Corp Preservation of organic materials by irradiation
US2920969A (en) 1954-08-25 1960-01-12 Gen Electric Method and means for irradiating foods
US2962380A (en) 1956-10-08 1960-11-29 Research Corp Radiation sterilization of fluid food products
US3620944A (en) 1967-09-09 1971-11-16 Osaka Prefecture Process of purifying water by irradiating it
US3743480A (en) 1971-04-09 1973-07-03 Allied Chem Sterilization of biological fluids
US3779706A (en) 1971-10-04 1973-12-18 Energy Sciences Inc Process for bulk sterilization, minimizing chemical and physical damage
US4136094A (en) 1977-08-31 1979-01-23 The Regents Of The University Of Minnesota Preparation of intravenous human and animal gamma globulins and isolation of albumin
US4282863A (en) 1978-07-20 1981-08-11 Beigler Myron A Methods of preparing and using intravenous nutrient compositions
US4336247A (en) 1978-09-05 1982-06-22 Eriksen Arthur E Body system nutrient material
IL58541A (en) 1978-11-01 1982-02-28 Nordisk Insulinlab Antihemophilic factor preparation from human blood plasma and a process for producing it
US4330626A (en) 1980-03-19 1982-05-18 The Enzyme Center, Inc. Method of preparing high-activity, low-bacteria, urease enzyme
DE3033932C2 (en) 1980-09-10 1984-05-24 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Process for the cold sterilization of preparations containing blood coagulation factor VIII
JPS57103649A (en) 1980-12-18 1982-06-28 Asahi Chemical Ind Sterilized gamma-globulin fixing column
US4472840A (en) 1981-09-21 1984-09-25 Jefferies Steven R Method of inducing osseous formation by implanting bone graft material
US4963356A (en) 1982-10-13 1990-10-16 Minnesota Mining And Manufacturing Company Stable antigenic extracts methods
US4727027A (en) 1983-05-02 1988-02-23 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
US4620908A (en) 1983-10-03 1986-11-04 Biocell Laboratories, Inc. Method for destroying microbial contamination in protein materials
US5106619A (en) 1983-12-20 1992-04-21 Diamond Scientific Co. Preparation of inactivated viral vaccines
JPH0687062B2 (en) 1985-05-10 1994-11-02 株式会社京都医科学研究所 How to prevent glycolysis in blood
SU1321420A1 (en) 1985-06-19 1987-07-07 Московский научно-исследовательский институт микрохирургии глаза Method of collagen coating for ophthalmological use
US4784850A (en) 1985-09-04 1988-11-15 Mutzarei Maabarot Process for preparing antibodies against E. Coli K-99 antigen from bovine milk
US5185371A (en) 1986-03-10 1993-02-09 University Of Southern California Method for disinfecting red blood cells
US4894253A (en) 1986-08-12 1990-01-16 University Of Cincinnati Method for production of coated electrode
US4798611A (en) 1986-10-14 1989-01-17 Hancock Jaffe Laboratories Enhancement of xenogeneic tissue
JPH0611290B2 (en) 1986-11-05 1994-02-16 住友ベークライト株式会社 Γ-ray sterilization method for polyvinyl alcohol gel
US4865602A (en) 1986-11-06 1989-09-12 Collagen Corporation Gamma irradiation of collagen/mineral mixtures
DE3640513A1 (en) 1986-11-27 1988-06-09 Biotest Pharma Gmbh METHOD FOR THE PRODUCTION OF A VIRUS-SAFE, STORAGE-STABLE AND INTRAVENOES COMPATIBLE IMMUNGLOBULIN-G-PRAEPARATES
US5000951A (en) 1987-03-09 1991-03-19 Diamond Scientific Company Multivalent canine distemper virus vaccine
DE3730533A1 (en) 1987-09-11 1989-03-30 Biotest Pharma Gmbh METHOD FOR STERILIZING PLASMA OR PLASMA FACTIONS
ES2067474T3 (en) 1987-09-28 1995-04-01 Beecham Inc PORK TGEV VIRUSES AS A VACCINE FOR DOGS.
ES2054641T3 (en) 1987-09-30 1994-08-16 Mucos Emulsions Gmbh USE OF CATABOLIC ENZYMES FOR THE PREPARATION OF A MEDICINAL PRODUCT INTENDED TO COMBAT ACQUIRED IMMUNODEFICIENCY (AIDS) AND ITS PREVIOUS STAGES (SLA AND CRS).
US4994237A (en) 1987-10-02 1991-02-19 The Beth Israel Hospital Association Microwave preservation of bioprostheses
GB8807187D0 (en) 1988-03-25 1988-04-27 Harrison J F Improvements in/relating to inactivation of infectious agents
GB8817240D0 (en) 1988-07-20 1988-08-24 Univ Salford Business Services Sterilising methods
US4931361A (en) 1988-11-18 1990-06-05 California Institute Of Technology Cryoprotective reagents in freeze-drying membranes
US5643464A (en) 1988-11-21 1997-07-01 Collagen Corporation Process for preparing a sterile, dry crosslinking agent
US5044091B1 (en) 1989-04-18 1997-12-30 Sankyo Co Method of preparing a freeze-dried formulation of a drug
US5283034A (en) 1989-06-29 1994-02-01 Applied Immune Sciences, Inc. Stabilization of sterilized surfaces for research and medical use
US5226065A (en) 1989-10-13 1993-07-06 Stericycle, Inc. Device for disinfecting medical materials
US5418130A (en) 1990-04-16 1995-05-23 Cryopharm Corporation Method of inactivation of viral and bacterial blood contaminants
ATE232737T1 (en) 1990-04-16 2003-03-15 Baxter Int METHOD FOR REMOVAL OF VIRAL AND BACTERIAL BLOOD CONTAMINATIONS
US6187572B1 (en) 1990-04-16 2001-02-13 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
JP3373201B2 (en) 1990-04-16 2003-02-04 バクスター インターナショナル インコーポレーテッド Inactivation method of blood contaminants of viruses and bacteria
DE4012398A1 (en) 1990-04-19 1991-10-24 Waelischmiller Hans Dipl Ing F RADIATION DEVICE
US5981163A (en) 1990-05-15 1999-11-09 New York Blood Center, Inc. Process for the sterilization of biological compositions using irradiation and quenchers of type I and type II photodynamic reactions
US5658722A (en) 1990-05-15 1997-08-19 New York Blood Center, Inc. Process for the sterilization of biological compositions using UVA1 irradiation
US5712086A (en) 1990-05-15 1998-01-27 New York Blood Center, Inc. Process for transfusing cell containing fractions sterilized with radiation and a quencher of type I and type II photodynamic reactions
US5360605A (en) 1990-09-04 1994-11-01 Edward Shanbrom Preservation of blood, tissues and biological fluids
US5089415A (en) * 1990-09-17 1992-02-18 International Technidyne Corp. Method for clotting heparized blood by the addition of protamine, thrombin and snake venom
US5618662A (en) 1992-03-02 1997-04-08 Cerus Corporation Intravenous administration of psoralen
US5641518A (en) 1992-11-13 1997-06-24 Purdue Research Foundation Method of repairing bone tissue
US5362442A (en) * 1993-07-22 1994-11-08 2920913 Canada Inc. Method for sterilizing products with gamma radiation
US5460962A (en) 1994-01-04 1995-10-24 Organogenesis Inc. Peracetic acid sterilization of collagen or collagenous tissue
US6203755B1 (en) 1994-03-04 2001-03-20 St. Jude Medical, Inc. Electron beam sterilization of biological tissues
EP0804734B1 (en) 1994-05-13 2005-05-04 Miltenyi Biotec GmbH Sterile and pyrogen-free columns coupled to protein for binding and removal of substances from blood
SE9401986D0 (en) 1994-06-08 1994-06-08 Pharmacia Ab New process for sterilization and articles sterilized thereby
US5603894A (en) 1994-10-31 1997-02-18 Abbott Laboratories Method of sterilizing a pharmaceutical composition
US5548066A (en) 1994-12-02 1996-08-20 Central Biomedia, Inc. Failure of passive transfer immune serum and method of making same
US6485723B1 (en) 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US5637451A (en) 1995-03-29 1997-06-10 New York Blood Center, Inc. Photodynamic treatment of red blood cells with phthalocyanines and red light at higher light fluence rates is protective of red blood cells
DE69622548T2 (en) 1995-04-07 2003-09-18 Purdue Research Foundation West Lafayette TISSUE TRANSPLANT FOR BUBBLE RECONSTRUCTION
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
JP3799626B2 (en) 1995-04-25 2006-07-19 有限会社ナイセム Cardiovascular repair material and method for producing the same
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US6235508B1 (en) 1995-06-07 2001-05-22 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
US6049025A (en) 1995-09-15 2000-04-11 Stone; Kevin R. Articular cartilage xenografts
US5691152A (en) 1995-11-09 1997-11-25 E. R. Squibb & Sons, Inc. Stable avidin composition
US5730933A (en) 1996-04-16 1998-03-24 Depuy Orthopaedics, Inc. Radiation sterilization of biologically active compounds
US6060233A (en) 1996-06-14 2000-05-09 Biostore New Zealand, Ltd Methods for the lyophilization of platelets, platelet membranes or erythrocytes
US5945128A (en) 1996-09-04 1999-08-31 Romano Deghenghi Process to manufacture implants containing bioactive peptides
US6190855B1 (en) 1996-10-28 2001-02-20 Baxter International Inc. Systems and methods for removing viral agents from blood
CA2274902C (en) 1996-12-10 2011-02-01 Purdue Research Foundation Submucosa extracts
US6696270B2 (en) 1996-12-10 2004-02-24 Purdue Research Foundation Gastric submucosal tissue as a novel diagnostic tool
JP4074666B2 (en) 1996-12-10 2008-04-09 クック バイオテック、インク． Tubular grafts from purified submucosa
US5856172A (en) 1997-01-03 1999-01-05 Quality Technologies, Llc Preservation of microorganisms in a vial with a cap comprising an immobilized desiccant
JP4271262B2 (en) 1997-02-10 2009-06-03 バイオメディカル デザイン インコーポレイテッド Sterilization method
US6383810B2 (en) 1997-02-14 2002-05-07 Invitrogen Corporation Dry powder cells and cell culture reagents and methods of production thereof
CA2217437A1 (en) 1997-04-25 1998-10-25 Mohamed Ressouany Biodegradable caseinate films and process for their production by irradiation
US5958669A (en) 1997-05-02 1999-09-28 St. Jude Medical, Inc. Apparatus and method for crosslinking to fix tissue or crosslink molecules to tissue
US6197207B1 (en) 1997-05-21 2001-03-06 Baxter International Inc. Method of reducing the possibility of transmission of spongiform encephalopathy diseases by blood products
US6010719A (en) 1997-09-16 2000-01-04 Universiteit Gent Freeze-dried disintegrating tablets
EP2147681A1 (en) 1997-10-29 2010-01-27 Genzyme Corporation Compositions and methods for treating lysosomal storage disease
DE19751284A1 (en) 1997-11-19 1999-05-27 Leo Prof Dr Gotzen Fixation element
US6000044A (en) 1997-11-26 1999-12-07 Digital Equipment Corporation Apparatus for randomly sampling instructions in a processor pipeline
US6383732B1 (en) 1999-02-11 2002-05-07 Crosscart, Inc. Method of preparing xenograft heart valves
US6157028A (en) 1998-05-28 2000-12-05 Jrh Biosciences, Inc. Method for dose mapping to ensure proper amounts of gamma irradiation
US20030068815A1 (en) 1999-02-11 2003-04-10 Stone Kevin R. Sterilized xenograft tissue
US6258821B1 (en) 1999-04-26 2001-07-10 Medimmune Oncology, Inc. Compositions comprising trimetrexate and methods of their synthesis and use
DE29913200U1 (en) 1999-07-28 1999-09-23 Tutogen Medical Gmbh Bone material implant
CN1120747C (en) 1999-08-17 2003-09-10 流动程序技术公司 Recovery process for oxidation catalyst in the manufacture of aromatic carboxylic acid
DE19952550A1 (en) 1999-11-02 2001-05-03 Tutogen Medical Gmbh Bone implant
DE19952939A1 (en) 1999-11-03 2001-05-10 Tutogen Medical Gmbh Bone material implant
DE19962248A1 (en) 1999-12-22 2001-06-28 Tutogen Medical Gmbh Producing bone material containing bone morphogenic protein, useful as transplant for accelerating bone growth, includes resorbable material for sustained release of protein
US6379385B1 (en) 2000-01-06 2002-04-30 Tutogen Medical Gmbh Implant of bone matter
US6312931B1 (en) 2000-02-11 2001-11-06 Purepulse Technologies, Inc. Protecting molecules in biologically derived compositions while treating with high intensity broad-spectrum pulsed light
DE10014616A1 (en) 2000-03-24 2001-09-27 Tutogen Medical Gmbh Cranium implant for use in brain surgery consists of a plate of spongy, cortical or compact bone material of human or animal origin preferably obtained by dehydration
DE10014617A1 (en) 2000-03-24 2001-09-27 Tutogen Medical Gmbh Orthopedic interference screw especially useful in crucial ligament repair has both the screw body and head made from human or animal bone preferably obtained by dehydration
AU2001263200A1 (en) * 2000-05-17 2001-11-26 The American National Red Cross Gamma irradiation of protein-based pharmaceutical products
DE10026306A1 (en) 2000-05-26 2001-11-29 Tutogen Medical Gmbh Jawbone transplant is domed and can be bent to U-shapes and is made of spongiose, cortical or compact bone material of human or animal origin
AU2002310364B2 (en) 2001-06-08 2006-02-23 Morris Innovative Research, Inc. Method and apparatus for sealing access
US6749851B2 (en) * 2001-08-31 2004-06-15 Clearant, Inc. Methods for sterilizing preparations of digestive enzymes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962038A (en) * 1972-03-09 1976-06-08 Director Of National Food Research Institute Preparation of water-insoluble enzymes
US5002776A (en) * 1983-12-22 1991-03-26 Elan Corporation, Plc Controlled absorption diltiazem formulations
JPH0898688A (en) * 1991-02-25 1996-04-16 Takeda Chem Ind Ltd Stabilization of bromelain solution
US5510122A (en) * 1994-09-28 1996-04-23 The Research Foundation Of State University Of New York Preparation and use of whole saliva

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1429617A4 *

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