WO2003020889A3 - Methods of maturing plasmacytoid dendritic cells using immune response modifier molecules - Google Patents

Methods of maturing plasmacytoid dendritic cells using immune response modifier molecules Download PDF

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Publication number
WO2003020889A3
WO2003020889A3 PCT/US2002/027393 US0227393W WO03020889A3 WO 2003020889 A3 WO2003020889 A3 WO 2003020889A3 US 0227393 W US0227393 W US 0227393W WO 03020889 A3 WO03020889 A3 WO 03020889A3
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WIPO (PCT)
Prior art keywords
methods
dendritic cells
plasmacytoid dendritic
maturing
immune response
Prior art date
Application number
PCT/US2002/027393
Other languages
French (fr)
Other versions
WO2003020889A2 (en
Inventor
Mark A Tomai
John P Vasilakos
John C Stolpa
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3M Innovative Properties Co
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Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Priority to JP2003525593A priority Critical patent/JP2005501550A/en
Priority to MXPA04001972A priority patent/MXPA04001972A/en
Priority to EP02766145A priority patent/EP1427445A4/en
Priority to CA002458876A priority patent/CA2458876A1/en
Publication of WO2003020889A2 publication Critical patent/WO2003020889A2/en
Publication of WO2003020889A3 publication Critical patent/WO2003020889A3/en

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract

The present invention relates to methods of maturing plasmacytoid dendritic cells using immune response modifier molecules. The present invention also relates to methods of detecting biological activities of matured plasmacytoid dendritic cells and methods of using mature plasmacytoid dendritic cells for therapeutic or prophylactic purposes.
PCT/US2002/027393 2001-08-30 2002-08-28 Methods of maturing plasmacytoid dendritic cells using immune response modifier molecules WO2003020889A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2003525593A JP2005501550A (en) 2001-08-30 2002-08-28 Maturation of plasmacytoid dendritic cells using immune response modifier molecules
MXPA04001972A MXPA04001972A (en) 2001-08-30 2002-08-28 Methods of maturing plasmacytoid dendritic cells using immune response modifier molecules.
EP02766145A EP1427445A4 (en) 2001-08-30 2002-08-28 Methods of maturing plasmacytoid dendritic cells using immune response modifier molecules
CA002458876A CA2458876A1 (en) 2001-08-30 2002-08-28 Methods of maturing plasmacytoid dendritic cells using immune response modifier molecules

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31614401P 2001-08-30 2001-08-30
US60/316,144 2001-08-30
US37017702P 2002-04-05 2002-04-05
US60/370,177 2002-04-05

Publications (2)

Publication Number Publication Date
WO2003020889A2 WO2003020889A2 (en) 2003-03-13
WO2003020889A3 true WO2003020889A3 (en) 2004-01-22

Family

ID=26980262

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/027393 WO2003020889A2 (en) 2001-08-30 2002-08-28 Methods of maturing plasmacytoid dendritic cells using immune response modifier molecules

Country Status (6)

Country Link
US (1) US20030133913A1 (en)
EP (1) EP1427445A4 (en)
JP (1) JP2005501550A (en)
CA (1) CA2458876A1 (en)
MX (1) MXPA04001972A (en)
WO (1) WO2003020889A2 (en)

Cited By (2)

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US8871782B2 (en) 2003-10-03 2014-10-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US8961477B2 (en) 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds

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US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
UA67760C2 (en) * 1997-12-11 2004-07-15 Міннесота Майнінг Енд Мануфакчурінг Компані Imidazonaphthyridines and use thereof to induce the biosynthesis of cytokines
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US7956043B2 (en) 2002-12-11 2011-06-07 Coley Pharmaceutical Group, Inc. 5′ CpG nucleic acids and methods of use
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US20040265351A1 (en) 2003-04-10 2004-12-30 Miller Richard L. Methods and compositions for enhancing immune response
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US7544697B2 (en) * 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
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US20050267145A1 (en) * 2004-05-28 2005-12-01 Merrill Bryon A Treatment for lung cancer
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WO2006074003A2 (en) 2004-12-30 2006-07-13 3M Innovative Properties Company CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS
US8034938B2 (en) 2004-12-30 2011-10-11 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
CA2592897A1 (en) * 2004-12-30 2006-07-13 Takeda Pharmaceutical Company Limited 1-(2-methylpropyl)-1h-imidazo[4,5-c][1,5]naphthyridin-4-amine ethanesulfonate and 1-(2-methylpropyl)-1h-imidazo[4,5-c][1,5]naphthyridin-4-amine methanesulfonate
JP2008526765A (en) * 2004-12-30 2008-07-24 スリーエム イノベイティブ プロパティズ カンパニー Treatment of skin metastases
WO2006084251A2 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
AU2006338521A1 (en) 2005-02-09 2007-10-11 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted thiazolo(4,5-c) ring compounds and methods
AU2006212765B2 (en) 2005-02-09 2012-02-02 3M Innovative Properties Company Alkyloxy substituted thiazoloquinolines and thiazolonaphthyridines
CA2597446A1 (en) 2005-02-11 2006-08-31 Coley Pharmaceutical Group, Inc. Substituted imidazoquinolines and imidazonaphthyridines
JP2008530113A (en) 2005-02-11 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド Oxime and hydroxyramine substituted imidazo [4,5-c] ring compounds and methods
AU2006216686A1 (en) 2005-02-23 2006-08-31 Coley Pharmaceutical Group, Inc. Method of preferentially inducing the biosynthesis of interferon
AU2006216799A1 (en) 2005-02-23 2006-08-31 Coley Pharmaceutical Group, Inc. Hydroxyalkyl substituted imidazonaphthyridines
JP2008531567A (en) 2005-02-23 2008-08-14 コーリー ファーマシューティカル グループ，インコーポレイテッド Hydroxyalkyl-substituted imidazoquinoline compounds and methods
US8178677B2 (en) 2005-02-23 2012-05-15 3M Innovative Properties Company Hydroxyalkyl substituted imidazoquinolines
MX2007011112A (en) 2005-03-14 2007-11-07 Graceway Pharmaceuticals Llc Method of treating actinic keratosis.
US7943610B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company Pyrazolopyridine-1,4-diamines and analogs thereof
US7943636B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company 1-substituted pyrazolo (3,4-C) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
JP2008539252A (en) * 2005-04-25 2008-11-13 スリーエム イノベイティブ プロパティズ カンパニー Immune activation composition
WO2007029689A1 (en) * 2005-09-08 2007-03-15 Medinet Co., Ltd. Method for activation treatment of antigen-presenting cell
EA200800782A1 (en) 2005-09-09 2008-08-29 Коли Фармасьютикал Груп, Инк. AMIDA AND CARBAMATE DERIVATIVES N- {2- [4-AMINO-2- (ETOXIMETHYL) -1H-IMIDAZOLO [4,5-c] QUINOLIN-1-IL] -1,1-DIMETHYLETHYL} METHANE SULFONAMIDE AND METHODS
ZA200803029B (en) 2005-09-09 2009-02-25 Coley Pharm Group Inc Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods
US20090297540A1 (en) * 2005-10-21 2009-12-03 Andrew Mellor Induction of Indoleamine 2,3-Dioxygenase in Dendritic Cells by TLR Ligands and Uses thereof
JP5247458B2 (en) 2005-11-04 2013-07-24 スリーエム・イノベイティブ・プロパティーズ・カンパニー Hydroxy and alkoxy substituted 1H-imidazoquinolines and methods
WO2007100634A2 (en) 2006-02-22 2007-09-07 3M Innovative Properties Company Immune response modifier conjugates
WO2007106854A2 (en) 2006-03-15 2007-09-20 Coley Pharmaceutical Group, Inc. Hydroxy and alkoxy substituted 1h-imidazonaphthyridines and methods
US7906506B2 (en) 2006-07-12 2011-03-15 3M Innovative Properties Company Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
US8178539B2 (en) 2006-09-06 2012-05-15 3M Innovative Properties Company Substituted 3,4,6,7-tetrahydro-5H-1,2a,4a,8-tetraazacyclopenta[cd]phenalenes and methods
US20080149123A1 (en) 2006-12-22 2008-06-26 Mckay William D Particulate material dispensing hairbrush with combination bristles
EP2310850B1 (en) * 2008-07-25 2018-10-17 Cellestis Limited A diagnostic method
HUE033901T2 (en) 2010-08-17 2018-01-29 3M Innovative Properties Co Lipidated immune response modifier compound compositions, formulations, and methods
JP6460789B2 (en) 2011-06-03 2019-01-30 スリーエム イノベイティブ プロパティズ カンパニー Heterobifunctional linker having polyethylene glycol segment and immune response modulating complex prepared from the linker
BR112013031039B1 (en) 2011-06-03 2020-04-28 3M Innovative Properties Co hydrazine compounds 1h-imidazoquinoline-4-amines, conjugates made from these compounds, composition and pharmaceutical composition comprising said compounds and conjugates, uses thereof and method of manufacturing the conjugate
US20130023736A1 (en) 2011-07-21 2013-01-24 Stanley Dale Harpstead Systems for drug delivery and monitoring
WO2015095143A1 (en) 2013-12-16 2015-06-25 The University Of North Carolina At Chapel Hill Depletion of plasmacytoid dendritic cells
CN105911292B (en) * 2016-05-19 2018-06-26 深圳市衍生生物科技有限公司 For combinatory analysis CD11c+CD11b+The kit and method of DC subgroups and its differentiation degree and function
US20200017831A1 (en) * 2016-09-23 2020-01-16 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Methods of preparing an isolated population of dendritic cells and methods of treating cancer using same
CA3088957A1 (en) * 2017-01-17 2018-07-26 Tufts Medical Center, Inc. Adoptive transfer of plasmacytoid dendritic cells to prevent or treat ocular diseases and conditions
KR101893886B1 (en) * 2017-01-31 2018-08-31 주식회사 큐라티스 Pharmaceutical composition for preventing or treating autoimmune disease and the method for preparing thereof
KR101946572B1 (en) * 2017-01-31 2019-02-11 주식회사 큐라티스 Toleorgenic plasmacytoid dendritic cells and the method for preparing thereof
KR20180089224A (en) * 2017-01-31 2018-08-08 주식회사 큐라티스 Pharmaceutical composition for preventing or treating hypersensitivity immune disease and the method for preparing thereof
EP3728255B1 (en) 2017-12-20 2022-01-26 3M Innovative Properties Company Amide substituted imidazo[4,5-c]quinoline compounds with a branched chain linking group for use as an immune response modifier
CN109797209B (en) * 2019-01-04 2021-07-16 中国人民解放军第二军医大学 Specific biomarker of dendritic cells and/or chemotactic states and functions thereof
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017279A1 (en) * 1996-10-25 1998-04-30 Minnesota Mining And Manufacturing Company Immune response modifier compounds for treatment of th2 mediated and related diseases
WO2000047719A2 (en) * 1999-02-11 2000-08-17 3M Innovative Properties Company Maturation of dendritic cells with immune response modifying compounds

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US246194A (en) * 1881-08-23 Waffle-iron
US394026A (en) * 1888-12-04 Carpenter s trestle
US246749A (en) * 1881-09-06 Washing-machine
US246193A (en) * 1881-08-23 Sewer-trap
US1104764A (en) * 1911-06-30 1914-07-28 Mary A Baird Flat-iron holder.
US3314941A (en) * 1964-06-23 1967-04-18 American Cyanamid Co Novel substituted pyridodiazepins
ZA848968B (en) * 1983-11-18 1986-06-25 Riker Laboratories Inc 1h-imidazo(4,5-c)quinolines and 1h-imidazo(4,5-c)quinolin-4-amines
US4698338A (en) * 1986-02-19 1987-10-06 Eli Lilly And Company 7[2-(2-aminothiazol-4-yl)-2-benzyloximino]acetamido-3[4-alkyl-5-oxo-6-hydroxy-3,4-dihydro-1,2,4-triazin-3-yl]thiomethyl cephalosporins
US5238944A (en) * 1988-12-15 1993-08-24 Riker Laboratories, Inc. Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
US5756747A (en) * 1989-02-27 1998-05-26 Riker Laboratories, Inc. 1H-imidazo 4,5-c!quinolin-4-amines
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
US5037986A (en) * 1989-03-23 1991-08-06 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo[4,5-c]quinolin-4-amines
US4988815A (en) * 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
ES2071340T3 (en) * 1990-10-05 1995-06-16 Minnesota Mining & Mfg PROCEDURE FOR THE PREPARATION OF IMIDAZO (4,5-C) QUINOLIN-4-AMINAS.
US5389640A (en) * 1991-03-01 1995-02-14 Minnesota Mining And Manufacturing Company 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5175296A (en) * 1991-03-01 1992-12-29 Minnesota Mining And Manufacturing Company Imidazo[4,5-c]quinolin-4-amines and processes for their preparation
US5268376A (en) * 1991-09-04 1993-12-07 Minnesota Mining And Manufacturing Company 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5266575A (en) * 1991-11-06 1993-11-30 Minnesota Mining And Manufacturing Company 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
IL105325A (en) * 1992-04-16 1996-11-14 Minnesota Mining & Mfg Immunogen/vaccine adjuvant composition
US5395937A (en) * 1993-01-29 1995-03-07 Minnesota Mining And Manufacturing Company Process for preparing quinoline amines
US5352784A (en) * 1993-07-15 1994-10-04 Minnesota Mining And Manufacturing Company Fused cycloalkylimidazopyridines
JPH09500128A (en) * 1993-07-15 1997-01-07 ミネソタ マイニング アンド マニュファクチャリング カンパニー Imidazo [4,5-c] pyridin-4-amine
US6207646B1 (en) * 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6429199B1 (en) * 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US6239116B1 (en) * 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
CA2194761C (en) * 1994-07-15 2006-12-19 Arthur M. Krieg Immunomodulatory oligonucleotides
US5482936A (en) * 1995-01-12 1996-01-09 Minnesota Mining And Manufacturing Company Imidazo[4,5-C]quinoline amines
US5741908A (en) * 1996-06-21 1998-04-21 Minnesota Mining And Manufacturing Company Process for reparing imidazoquinolinamines
US5693811A (en) * 1996-06-21 1997-12-02 Minnesota Mining And Manufacturing Company Process for preparing tetrahdroimidazoquinolinamines
ES2232871T3 (en) * 1996-07-03 2005-06-01 Sumitomo Pharmaceuticals Company, Limited NEW DERIVATIVES OF PURINA.
US5939090A (en) * 1996-12-03 1999-08-17 3M Innovative Properties Company Gel formulations for topical drug delivery
JP4101302B2 (en) * 1997-01-09 2008-06-18 テルモ株式会社 Novel amide derivatives and synthetic intermediates
US6406705B1 (en) * 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
EP1003531B1 (en) * 1997-05-20 2007-08-22 Ottawa Health Research Institute Processes for preparing nucleic acid constructs
US6329381B1 (en) * 1997-11-28 2001-12-11 Sumitomo Pharmaceuticals Company, Limited Heterocyclic compounds
UA67760C2 (en) * 1997-12-11 2004-07-15 Міннесота Майнінг Енд Мануфакчурінг Компані Imidazonaphthyridines and use thereof to induce the biosynthesis of cytokines
TW572758B (en) * 1997-12-22 2004-01-21 Sumitomo Pharma Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives
US6110929A (en) * 1998-07-28 2000-08-29 3M Innovative Properties Company Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
US20020058674A1 (en) * 1999-01-08 2002-05-16 Hedenstrom John C. Systems and methods for treating a mucosal surface
CA2361936C (en) * 1999-01-08 2009-06-16 3M Innovative Properties Company Formulations comprising imiquimod or other immune response modifiers for treating mucosal conditions
US6451810B1 (en) * 1999-06-10 2002-09-17 3M Innovative Properties Company Amide substituted imidazoquinolines
US6331539B1 (en) * 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
US6083969A (en) * 1999-10-20 2000-07-04 Ortho-Mcneil Pharaceutical, Inc. 1,3- and 2,3-diarylcycloalkano and cycloalkeno pyrazoles as selective inhibitors of cyclooxygenase-2 and antiinflammatory agents
US6376669B1 (en) * 1999-11-05 2002-04-23 3M Innovative Properties Company Dye labeled imidazoquinoline compounds
US20020055517A1 (en) * 2000-09-15 2002-05-09 3M Innovative Properties Company Methods for delaying recurrence of herpes virus symptoms
US20030139364A1 (en) * 2001-10-12 2003-07-24 University Of Iowa Research Foundation Methods and products for enhancing immune responses using imidazoquinoline compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017279A1 (en) * 1996-10-25 1998-04-30 Minnesota Mining And Manufacturing Company Immune response modifier compounds for treatment of th2 mediated and related diseases
WO2000047719A2 (en) * 1999-02-11 2000-08-17 3M Innovative Properties Company Maturation of dendritic cells with immune response modifying compounds

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
AHONEN C.L. ET AL.: "Dendritic cell maturation and subsequent enhanced T-cell stimulation induced with the novel synthetic immune response modifier R-848", CELL IMMUNOL., vol. 197, no. 1, October 1999 (1999-10-01), pages 62 - 72, XP000939324 *
BURNS R.P. ET AL.: "The imidazoquinolines, imiquimod and R-848, induced functional, but not phenotypic, maturation of human epidermal langerhans' cells", CLIN. IMMUNOL., vol. 94, no. 1, January 2000 (2000-01-01), pages 13 - 23, XP002964628 *
GRABBE S. ET AL.: "R848 activates immature dendritic cells in vitro and modulates the sensitization and effector phase of murine contact hypersensitivity (CHS) responses", J. INVEST. DERMATOL., vol. 117, no. 2, August 2001 (2001-08-01), pages 447, ABSTRACT NO.346, XP002964629 *
GUNZER M. ET AL.: "The immune response modifier R-848 in a Th1-polarizing agent for immature but not precursor murine dendritic cells", ARCH. DERMATOL. RES., vol. 293, no. 1-2, February 2001 (2001-02-01), pages 54, ABSTRACT NO.P45, XP002964630 *
MILLER R.L. ET AL.: "Treatment of primary herpes simplex virus infection in guinea pigs by imiquimod", ANTIVIRAL RES., vol. 44, no. 1, November 1999 (1999-11-01), pages 31 - 42, XP002964632 *
SUZUKI H. ET AL.: "Imiquimod, a topical immune response modifier, induces migration of langerhans cells", J. INVEST. DERMATOLOGY, vol. 114, no. 1, January 2000 (2000-01-01), pages 135 - 141, XP002964631 *
VASILAKOS J.P. ET AL.: "Adjuvant activities of immune response modifier R-848: comparison with CpG ODN", CELL IMMUNOL., vol. 204, no. 1, 2000, pages 64 - 74, XP001037913 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8961477B2 (en) 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds
US8871782B2 (en) 2003-10-03 2014-10-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines

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