WO2003022217A3 - Treatment of excessive radiation (e.g. sunburn) exposure - Google Patents

Treatment of excessive radiation (e.g. sunburn) exposure Download PDF

Info

Publication number
WO2003022217A3
WO2003022217A3 PCT/US2002/028692 US0228692W WO03022217A3 WO 2003022217 A3 WO2003022217 A3 WO 2003022217A3 US 0228692 W US0228692 W US 0228692W WO 03022217 A3 WO03022217 A3 WO 03022217A3
Authority
WO
WIPO (PCT)
Prior art keywords
compound
solubility
sunburn
exposure
treatment
Prior art date
Application number
PCT/US2002/028692
Other languages
French (fr)
Other versions
WO2003022217A9 (en
WO2003022217A2 (en
Inventor
Jen-Chang Hsia
Li Ma
Original Assignee
Synzyme Technologies Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synzyme Technologies Llc filed Critical Synzyme Technologies Llc
Priority to AU2002333535A priority Critical patent/AU2002333535A1/en
Publication of WO2003022217A2 publication Critical patent/WO2003022217A2/en
Publication of WO2003022217A3 publication Critical patent/WO2003022217A3/en
Publication of WO2003022217A9 publication Critical patent/WO2003022217A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Abstract

A method is disclosed whereby a formulation is applied to the skin of a patient which may be a human. The formulation is comprised of a carrier and a compound which has a first lipid solubility and a first aqueous solubility. The compound is allowed to permeate the patient's skin and reach viable cells and react in the presence of enzymes of the cells. The reaction results in a compound which has a second lipid solubility which is substantially less than the first lipid solubility and also obtain a second aqueous solubility which is substantially greater than the first aqueous solubility thereby allowing the compound to permeate to viable cells and remain in contact with those cells. The compound may be a nitroxide which aids in modulating adverse effects of reactive oxygen species.
PCT/US2002/028692 2001-09-06 2002-09-06 Treatment of excessive radiation (e.g. sunburn) exposure WO2003022217A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002333535A AU2002333535A1 (en) 2001-09-06 2002-09-06 Treatment of excessive radiation (e.g. sunburn) exposure

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/948,505 2001-09-06
US09/948,505 US20030045461A1 (en) 2001-09-06 2001-09-06 Composition and methods of esterified nitroxides gated with carboxylic acids

Publications (3)

Publication Number Publication Date
WO2003022217A2 WO2003022217A2 (en) 2003-03-20
WO2003022217A3 true WO2003022217A3 (en) 2003-12-04
WO2003022217A9 WO2003022217A9 (en) 2004-04-15

Family

ID=25487919

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2002/028692 WO2003022217A2 (en) 2001-09-06 2002-09-06 Treatment of excessive radiation (e.g. sunburn) exposure
PCT/US2002/028761 WO2003022246A1 (en) 2001-09-06 2002-09-06 Treating effects of excessive reactive oxygen species
PCT/US2002/028693 WO2003022218A2 (en) 2001-09-06 2002-09-06 Carboxylate-gated-nitroxide (cgn) compounds and compositions and methods of use thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US2002/028761 WO2003022246A1 (en) 2001-09-06 2002-09-06 Treating effects of excessive reactive oxygen species
PCT/US2002/028693 WO2003022218A2 (en) 2001-09-06 2002-09-06 Carboxylate-gated-nitroxide (cgn) compounds and compositions and methods of use thereof

Country Status (7)

Country Link
US (5) US20030045461A1 (en)
EP (1) EP1429723B1 (en)
JP (1) JP4541699B2 (en)
CN (1) CN100430067C (en)
AT (1) ATE555787T1 (en)
AU (2) AU2002333536A1 (en)
WO (3) WO2003022217A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003247816A1 (en) * 2002-07-02 2004-01-23 Procyte Corporation Compositions containing peptide copper complexes and soft tissue fillers
CA2527522A1 (en) * 2003-05-29 2004-12-09 Kenneth Chang Methods of using nitroxides in conjunction with photosensitizers and sonosensitizers
US20100121273A1 (en) * 2005-06-22 2010-05-13 Kochanek Patrick M Emergency preservation and resuscitation methods
US20110027200A1 (en) * 2009-07-30 2011-02-03 Bernstein Eric F Methods to stabilize and prevent breakdown of sunscreen and other topical and oral preparations and compositions produced thereby
US8859235B2 (en) * 2009-08-14 2014-10-14 Basf Se Methods in cell cultures, and related inventions, employing certain additives
US8778969B2 (en) 2009-11-07 2014-07-15 Peter H Proctor Nitrone, nitroso, and nitroxide spintraps and spin labels and their hydroxylamines
US8883409B1 (en) 2013-12-08 2014-11-11 Hemalux LLC Method of reducing pathogens in whole blood by illuminating with ultraviolet light under low oxygen conditions
CN112851571A (en) * 2021-01-26 2021-05-28 陕西海辰风扬医药科技有限公司 Preparation method and application of 2- (2, 2,6, 6-tetramethylpiperidine nitroxide radical-4-subunit) acetic acid derivative

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840734A (en) * 1997-05-06 1998-11-24 Thomas Jefferson University Use of tempol in the prevention of photoaging
US6048967A (en) * 1993-08-16 2000-04-11 Synzyme Technologies, Inc. Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
WO2000078316A1 (en) * 1999-06-23 2000-12-28 Bernstein Eric F Use of nitroxides in wound healing and in the prevention of photodamage

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4240797A (en) * 1977-10-18 1980-12-23 The Governing Council Of The University Of Toronto Assay for reserve bilirubin binding capacity
CH636252A5 (en) * 1978-10-20 1983-05-31 Syntech Sa ERGONOMIC CHAIR.
US5728714A (en) * 1985-07-18 1998-03-17 Proctor; Peter H. Method for treating hair loss using tempo
US5716947A (en) * 1985-07-18 1998-02-10 Proctor; Peter H. Topical doxyl composition and method
US5714482A (en) * 1985-07-18 1998-02-03 Proctor; Peter H. Topical spin labels and method
US5714510A (en) * 1985-07-18 1998-02-03 Proctor; Peter H. Topical proxyl composition and method
US5352442A (en) * 1985-07-18 1994-10-04 Proctor Peter H Topical tempo
US5723502A (en) * 1985-07-18 1998-03-03 Proctor; Peter H. Topical spin trap composition and method
GB8522535D0 (en) * 1985-09-11 1985-10-16 Amersham Int Plc Contrast agent
AU1107888A (en) * 1986-12-29 1988-07-27 Pharmacia Ab Nitroxide compounds for the preparation of a pharmaceutical composition intended for the prophylaxis and treatment of ischemic cell damage
US5178433A (en) * 1987-06-12 1993-01-12 Frank Wagner Vehicle body mount
USRE35213E (en) * 1989-10-17 1996-04-16 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
US5622994A (en) * 1989-10-17 1997-04-22 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
CA2069961C (en) 1989-10-17 2000-05-02 John M. Carney Method and compositions for inhibition of disorders associated with oxidative damage
US5036097A (en) * 1989-10-17 1991-07-30 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
US5025032A (en) * 1989-10-17 1991-06-18 Oklahoma Medical Research Foundation Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage
WO1991013619A1 (en) * 1990-03-16 1991-09-19 The United States Of America, Represented By The Secretary, United States Department Of Commerce Nitroxides as protectors against oxidative stress
US5211937A (en) 1990-07-30 1993-05-18 Glycomed Incorporated Method of determining a site of inflammation utilizing elam-1 ligands
US6002001A (en) * 1991-06-18 1999-12-14 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
US5338539A (en) 1992-08-04 1994-08-16 3V Inc. Benzofuran derivatives useful as sunscreens
FR2695560B1 (en) 1992-09-17 1994-11-04 Oreal Photostable filtering cosmetic composition containing a UV-A filter and a filter polymer of the benzotriazole silicone type.
US5362481A (en) 1993-03-05 1994-11-08 3V Inc. Benzofuran derivatives and the use thereof as stabilizers against UV radiations
US5824781A (en) * 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5741893A (en) * 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5725839A (en) * 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
US5767089A (en) * 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5807831A (en) * 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5804561A (en) * 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
FR2714604B1 (en) * 1993-12-30 1996-01-26 Oreal Use of a spin acceptor in a cosmetic or dermatological composition.
US5601811A (en) 1994-08-01 1997-02-11 Croda, Inc. Substantive water-soluble cationic UV-absorbing compounds
DE69525217T2 (en) 1994-10-14 2002-10-24 Hoffmann La Roche Light-stable cosmetic sunscreens
US5981548A (en) * 1994-11-15 1999-11-09 Moreno Paolini N-Hydroxypiperidines as superoxide radicals scavengers
US5518713A (en) 1995-02-13 1996-05-21 3V Inc. Benzoxazole derivatives, the use thereof as sunscreens and cosmetic compositions containing them
EP0833812A1 (en) 1995-06-23 1998-04-08 Zylepsis Limited Chemical compounds and methods of production thereof
JP3155685B2 (en) * 1995-07-20 2001-04-16 財団法人山形県企業振興公社 Method for measuring peroxidase
DE69726144T9 (en) * 1996-05-07 2004-09-09 Bernstein, Eric F. TOPICAL USE OF TEMPOL TO PREVENT LIGHT AGING
EP0995740A4 (en) * 1997-06-27 2001-01-17 Daiichi Radioisotope Lab Novel nitroxyl compounds and drugs and reagents containing the same as the active ingredient
GB9801398D0 (en) * 1998-01-22 1998-03-18 Anggard Erik E Chemical compounds
US6017315A (en) * 1998-02-25 2000-01-25 Respironics, Inc. Patient monitor and method of using same
WO2000003977A1 (en) * 1998-07-17 2000-01-27 Centaur Pharmaceuticals, Inc. Alpha-(2-hydroxyphenyl) nitrone compounds, pharmaceutical compositions containing the same and their use for treating inflammation
UA66401C2 (en) * 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
US6235931B1 (en) * 1998-12-30 2001-05-22 Shell Oil Company Partial oxidation of polyoxyalkylene polyol compositions to polycarboxylic acid compositions
FR2791979B1 (en) * 1999-04-08 2003-05-16 Atochem Elf Sa PROCESS FOR THE PREPARATION OF ALCOXYAMINES FROM NITROXIDES
US20030134780A1 (en) * 2001-10-05 2003-07-17 Procyte Corporation Skin care compositions containing peptide copper complexes and retinol, retinol derivatives, or a mixture thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048967A (en) * 1993-08-16 2000-04-11 Synzyme Technologies, Inc. Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
US5840734A (en) * 1997-05-06 1998-11-24 Thomas Jefferson University Use of tempol in the prevention of photoaging
WO2000078316A1 (en) * 1999-06-23 2000-12-28 Bernstein Eric F Use of nitroxides in wound healing and in the prevention of photodamage

Also Published As

Publication number Publication date
WO2003022246A1 (en) 2003-03-20
CN1553797A (en) 2004-12-08
EP1429723A1 (en) 2004-06-23
US7314633B2 (en) 2008-01-01
ATE555787T1 (en) 2012-05-15
WO2003022218A3 (en) 2003-10-16
EP1429723B1 (en) 2012-05-02
WO2003022217A9 (en) 2004-04-15
CN100430067C (en) 2008-11-05
WO2003022217A2 (en) 2003-03-20
US20030078241A1 (en) 2003-04-24
EP1429723A4 (en) 2005-06-15
AU2002333535A1 (en) 2003-03-24
US20030092764A1 (en) 2003-05-15
US20030045461A1 (en) 2003-03-06
US20030113278A1 (en) 2003-06-19
JP2005505556A (en) 2005-02-24
US7229629B2 (en) 2007-06-12
US20070092540A1 (en) 2007-04-26
JP4541699B2 (en) 2010-09-08
AU2002333536A1 (en) 2003-03-24
WO2003022218A2 (en) 2003-03-20

Similar Documents

Publication Publication Date Title
AU2161888A (en) Anti-acne composition
US6309656B1 (en) Cosmetic and skin protective compositions
AU2118488A (en) Improvements in or relating to methods of treating damaged skin
CA2335959A1 (en) Colorants
CA2150870A1 (en) Cosmetic Sunscreens and Their Uses
CA2339252A1 (en) Treatment of pigmented tissues using optical energy
WO2003094725A8 (en) Anti-inflammatory biosensor for reduced biofouling and enhanced sensor performance
EP0875241A3 (en) Aqueous cosmetic composition containing stably solubilized uric acid and water-soluble polymer and method for stably solubilizing uric acid in aqueous cosmetic composition
JPS5910324B2 (en) Cosmetic composition for skin or hair
IN1997DE00284A (en)
MXPA02010941A (en) Oxidating composition for the treatment of keratin fibres including a specific amino silicone.
CA2219654A1 (en) Compositions and methods for stimulating hair growth
AU3956599A (en) Surfactant for use in external preparations for skin and external preparation for skin containing the same
NO20045019L (en) Pharmaceutical preparation
FI940659A0 (en) Heterocyclic-substituted phenylcyclohexanecarboxylic acid derivatives
WO2003022217A3 (en) Treatment of excessive radiation (e.g. sunburn) exposure
AU674142B2 (en) Use of cosmetic composition
AU3710693A (en) Sulfonylbenzyl-substituted benzo- and pyridopyridones
NZ506681A (en) Disinfecting composition
WO2002058665A8 (en) Skin care composition
WO2000061124A3 (en) Use off cell membrane penetrating indigoid bisindole derivatives
AU4381397A (en) A process and formulations for the permanent deforming of keratin fibres
MXPA05009527A (en) Lip implant and method for insertion.
EP0993825A3 (en) Urea containing composition and its cosmetic and dermatologic use
CA2089657A1 (en) Topical treatment of blepharitis

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG UZ VC VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
COP Corrected version of pamphlet

Free format text: PAGES 1/27-27/27, DRAWINGS, REPLACED BY NEW PAGES 1/27-27/27; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP