WO2003026643A3 - Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors - Google Patents

Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors Download PDF

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Publication number
WO2003026643A3
WO2003026643A3 PCT/US2002/029652 US0229652W WO03026643A3 WO 2003026643 A3 WO2003026643 A3 WO 2003026643A3 US 0229652 W US0229652 W US 0229652W WO 03026643 A3 WO03026643 A3 WO 03026643A3
Authority
WO
WIPO (PCT)
Prior art keywords
xanthoma
treatment
absorption inhibitors
sterol absorption
azetidinone derivatives
Prior art date
Application number
PCT/US2002/029652
Other languages
French (fr)
Other versions
WO2003026643A2 (en
Inventor
Harry R Davis
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to DE60216300T priority Critical patent/DE60216300T2/en
Priority to SI200230440T priority patent/SI1429756T1/en
Priority to JP2003530280A priority patent/JP2005504091A/en
Priority to EP02773469A priority patent/EP1429756B1/en
Priority to MXPA04002573A priority patent/MXPA04002573A/en
Priority to DK02773469T priority patent/DK1429756T3/en
Priority to CA2460340A priority patent/CA2460340C/en
Priority to AU2002336609A priority patent/AU2002336609B2/en
Publication of WO2003026643A2 publication Critical patent/WO2003026643A2/en
Publication of WO2003026643A3 publication Critical patent/WO2003026643A3/en
Priority to CY20061101869T priority patent/CY1105892T1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The present invention provides therapeutic combinations and methods including at least one sterol or 5α-stanol absorption inhibitor that can be useful for treating xanthomas.
PCT/US2002/029652 2001-09-21 2002-09-19 Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors WO2003026643A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DE60216300T DE60216300T2 (en) 2001-09-21 2002-09-19 TREATMENT OF XANTHOM BY AZETIDINONE DERIVATIVES AS AN INHIBITOR OF STEROL ABSORPTION
SI200230440T SI1429756T1 (en) 2001-09-21 2002-09-19 Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
JP2003530280A JP2005504091A (en) 2001-09-21 2002-09-19 Treatment of xanthomas with azetidinone as a sterol absorption inhibitor
EP02773469A EP1429756B1 (en) 2001-09-21 2002-09-19 Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
MXPA04002573A MXPA04002573A (en) 2001-09-21 2002-09-19 Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors.
DK02773469T DK1429756T3 (en) 2001-09-21 2002-09-19 Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
CA2460340A CA2460340C (en) 2001-09-21 2002-09-19 Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors
AU2002336609A AU2002336609B2 (en) 2001-09-21 2002-09-19 Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
CY20061101869T CY1105892T1 (en) 2001-09-21 2006-12-29 TREATMENT OF XANTHOMA WITH AZETIDINONE DERIVATIVES AS STEPOLIS ABSORPTION INHIBITORS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32394201P 2001-09-21 2001-09-21
US60/323,942 2001-09-21

Publications (2)

Publication Number Publication Date
WO2003026643A2 WO2003026643A2 (en) 2003-04-03
WO2003026643A3 true WO2003026643A3 (en) 2003-07-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/029652 WO2003026643A2 (en) 2001-09-21 2002-09-19 Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors

Country Status (13)

Country Link
US (2) US7132415B2 (en)
EP (1) EP1429756B1 (en)
JP (1) JP2005504091A (en)
AT (1) ATE345793T1 (en)
AU (1) AU2002336609B2 (en)
CA (1) CA2460340C (en)
CY (1) CY1105892T1 (en)
DE (1) DE60216300T2 (en)
DK (1) DK1429756T3 (en)
ES (1) ES2272776T3 (en)
MX (1) MXPA04002573A (en)
PT (1) PT1429756E (en)
WO (1) WO2003026643A2 (en)

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US7235543B2 (en) 2003-03-07 2007-06-26 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7208486B2 (en) 2003-03-07 2007-04-24 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
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JP2007510659A (en) * 2003-11-05 2007-04-26 シェーリング　コーポレイション Combinations of lipid modulators and substituted azetidinones and treatment of vascular conditions
ATE485267T1 (en) 2003-12-23 2010-11-15 Astrazeneca Ab DIPHENYLAZETIDINONE DERIVATIVES WITH CHOLESTERINE ABSORPTION INHIBITING EFFECT
US7838552B2 (en) 2004-06-04 2010-11-23 Forest Laboratories Holdings Limited Compositions comprising nebivolol
US7803838B2 (en) 2004-06-04 2010-09-28 Forest Laboratories Holdings Limited Compositions comprising nebivolol
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UY29607A1 (en) 2005-06-20 2007-01-31 Astrazeneca Ab CHEMICAL COMPOUNDS
SA06270191B1 (en) 2005-06-22 2010-03-29 استرازينيكا ايه بي Novel 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors for the Treatment of Hyperlipidaemic Conditions
MY148538A (en) 2005-06-22 2013-04-30 Astrazeneca Ab Novel 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions
TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
PL2547679T3 (en) 2010-03-19 2016-02-29 Pfizer 2,3 dihydro-1h-inden-1-yl-2,7-diazaspiro[3.6]nonane derivatives and their use as antagonists or inverse agonists of the ghrelin receptor
ES2552657T3 (en) 2010-05-26 2015-12-01 Satiogen Pharmaceuticals, Inc. Inhibitors of the recycling of bile acids and satiogens for the treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
CA2852957C (en) 2011-10-28 2020-08-04 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
US20140243281A1 (en) 2011-10-28 2014-08-28 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
JP2016514684A (en) 2013-03-15 2016-05-23 ルメナ ファーマシューティカルズ エルエルシー Bile acid recirculation inhibitors for the treatment of primary sclerosing cholangitis and inflammatory bowel disease
BR112015023697A2 (en) 2013-03-15 2017-07-18 Lumena Pharmaceuticals Inc recycling bile acid inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease
WO2016111265A1 (en) * 2015-01-08 2016-07-14 江崎グリコ株式会社 Antioxidant agent, and antioxidant cosmetic and uv care cosmetic
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