WO2003032953A1 - Granules contenant un agent chimique instable en milieu acide, en concentration elevee - Google Patents

Granules contenant un agent chimique instable en milieu acide, en concentration elevee Download PDF

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Publication number
WO2003032953A1
WO2003032953A1 PCT/JP2002/010720 JP0210720W WO03032953A1 WO 2003032953 A1 WO2003032953 A1 WO 2003032953A1 JP 0210720 W JP0210720 W JP 0210720W WO 03032953 A1 WO03032953 A1 WO 03032953A1
Authority
WO
WIPO (PCT)
Prior art keywords
unstable chemical
large amount
containing acid
granules containing
acid
Prior art date
Application number
PCT/JP2002/010720
Other languages
English (en)
French (fr)
Inventor
Toshihiro Shimizu
Yoshinori Nakano
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19136997&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003032953(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Priority to CA2463690A priority Critical patent/CA2463690C/en
Priority to DK02775358.1T priority patent/DK1459737T3/da
Priority to ES02775358T priority patent/ES2392960T3/es
Priority to EP02775358A priority patent/EP1459737B1/en
Priority to US10/492,690 priority patent/US8105626B2/en
Publication of WO2003032953A1 publication Critical patent/WO2003032953A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
PCT/JP2002/010720 2001-10-17 2002-10-16 Granules contenant un agent chimique instable en milieu acide, en concentration elevee WO2003032953A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA2463690A CA2463690C (en) 2001-10-17 2002-10-16 Granules containing acid-unstable chemical in large amount
DK02775358.1T DK1459737T3 (da) 2001-10-17 2002-10-16 Granulat indeholdende syreustabilt kemisk middel i stor mængde
ES02775358T ES2392960T3 (es) 2001-10-17 2002-10-16 Gránulos que contienen gran cantidad de compuesto químico inestable en medio ácido
EP02775358A EP1459737B1 (en) 2001-10-17 2002-10-16 Granules containing acid-unstable chemical in large amount
US10/492,690 US8105626B2 (en) 2001-10-17 2002-10-16 Granules containing acid-unstable chemical in large amount

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-319444 2001-10-17
JP2001319444 2001-10-17

Publications (1)

Publication Number Publication Date
WO2003032953A1 true WO2003032953A1 (fr) 2003-04-24

Family

ID=19136997

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/010720 WO2003032953A1 (fr) 2001-10-17 2002-10-16 Granules contenant un agent chimique instable en milieu acide, en concentration elevee

Country Status (9)

Country Link
US (1) US8105626B2 (ja)
EP (2) EP1459737B1 (ja)
CN (1) CN100562317C (ja)
CA (1) CA2463690C (ja)
CY (2) CY1113763T1 (ja)
DK (2) DK1459737T3 (ja)
ES (2) ES2426723T3 (ja)
PT (2) PT2258351E (ja)
WO (1) WO2003032953A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004035052A1 (ja) * 2002-10-16 2004-04-29 Takeda Pharmaceutical Company Limited 安定な固形製剤
WO2004080439A1 (ja) * 2003-03-12 2004-09-23 Takeda Pharmaceutical Company Limited 高濃度に活性成分を球形核に付着させた医薬組成物
WO2005025569A1 (en) * 2003-09-18 2005-03-24 Altana Pharma Ag Use of known active ingredients as radical scavengers
WO2005084649A1 (ja) * 2004-03-04 2005-09-15 Takeda Pharmaceutical Company Limited 安定なカプセル剤
WO2006118017A1 (ja) * 2005-04-28 2006-11-09 Eisai R & D Management Co., Ltd. 安定化組成物
US8124780B2 (en) 2005-04-15 2012-02-28 Eisai R&D Management Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI372066B (en) * 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
AU2005264864B2 (en) 2004-06-16 2011-08-11 Takeda Pharmaceutical Company Limited Multiple PPI dosage form
CA2599340C (en) 2005-02-25 2012-12-04 Takeda Pharmaceutical Company Limited Method for producing granules
US20060252830A1 (en) * 2005-05-06 2006-11-09 Brandon Stephen F Method for the treatment of magnesium and potassium deficiencies
US20060252831A1 (en) * 2005-05-06 2006-11-09 Christopher Offen Method for the treatment of magnesium and potassium deficiencies
US7842312B2 (en) 2005-12-29 2010-11-30 Cordis Corporation Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same
RU2435569C2 (ru) * 2006-03-16 2011-12-10 Трис Фарма, Инк. Композиции с модифицированным высвобождением, содержащие комплексы лекарственное вещество - ионообменная смола
EP2486910A3 (en) 2006-10-27 2012-08-22 The Curators Of The University Of Missouri Multi-chambered apparatus comprising a dispenser head
ITMI20062290A1 (it) * 2006-11-28 2008-05-29 Monteres S R L Compresse stabili allo stoccaggio a base di derivati del benzimidazolo rivestite con film gastro-resistente
US9486446B2 (en) * 2006-12-28 2016-11-08 Takeda Pharmaceutical Company Limited Orally disintegrating solid preparation
AU2008310735B2 (en) * 2007-10-12 2013-09-12 Takeda Pharmaceutical Company Limited Methods of treating gastrointestinal disorders independent of the intake of food
US8247440B2 (en) 2008-02-20 2012-08-21 Curators Of The University Of Missouri Composition comprising omeprazole, lansoprazole and at least one buffering agent
US20130216617A1 (en) 2010-06-29 2013-08-22 Cadila Healthcare Limited Pharmaceutical compositions of (r)-lansoprazole
EP2535045A1 (en) * 2011-06-15 2012-12-19 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical composition of lansoprazole
WO2013141827A1 (en) * 2012-03-21 2013-09-26 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Enteric coated solid pharmaceutical compositions for proton pump inhibitors
WO2014016754A2 (en) 2012-07-26 2014-01-30 Lupin Limited Pharmaceutical compositions of proton pump inhibitor
CN104414994A (zh) * 2013-08-24 2015-03-18 湖北欧立制药有限公司 兰索拉唑肠溶胶囊及其制备工艺
CN104546790A (zh) * 2013-10-15 2015-04-29 悦康药业集团有限公司 一种兰索拉唑肠溶胶囊及其制备方法
CN104173342A (zh) * 2014-07-30 2014-12-03 福州闽海药业有限公司 一种右旋兰索拉唑组合物
CN105769824A (zh) * 2014-12-16 2016-07-20 四川海思科制药有限公司 一种兰索拉唑缓释胶囊及其制备方法
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US11590228B1 (en) 2015-09-08 2023-02-28 Tris Pharma, Inc Extended release amphetamine compositions
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
CZ2017315A3 (cs) * 2017-06-02 2018-12-12 Zentiva, K.S. Dávkovací jednotka s PPI (inhibitory protonové pumpy)
KR102609676B1 (ko) 2017-06-12 2023-12-05 글리테크 엘엘씨. Nmda 길항제 및 d2/5ht2a 또는 선택적 5ht2a 길항제를 이용한 우울증의 치료
US11590081B1 (en) 2017-09-24 2023-02-28 Tris Pharma, Inc Extended release amphetamine tablets
CN111789808A (zh) * 2019-04-08 2020-10-20 生达化学制药股份有限公司 口服医药组成物及其结构

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0237200A2 (en) * 1986-02-13 1987-09-16 Takeda Chemical Industries, Ltd. Use of basic inorganic salts of magnesium or calcium for the stabilisation of benzimidazole derivatives
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
EP0277741A1 (en) * 1987-01-29 1988-08-10 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
JPH05139964A (ja) * 1991-11-14 1993-06-08 Takada Seiyaku Kk 塩酸メキシレチン腸溶性製剤
JPH05255088A (ja) * 1991-11-05 1993-10-05 Yoshitomi Pharmaceut Ind Ltd 抗潰瘍剤含有製剤
JPH07223956A (ja) * 1994-02-09 1995-08-22 Taiyo Yakuhin Kogyo Kk 塩酸ニカルジピンの徐放剤用製剤およびこれを利用した徐放化製剤
JPH11139960A (ja) * 1997-09-05 1999-05-25 Takeda Chem Ind Ltd 医 薬

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS62277322A (ja) 1986-02-13 1987-12-02 Takeda Chem Ind Ltd 安定化された腸溶性抗潰瘍固形組成物
GB2189699A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated acid-labile medicaments
JPH0832625B2 (ja) 1987-01-29 1996-03-29 武田薬品工業株式会社 有核顆粒およびその製造法
SE9302395D0 (sv) * 1993-07-09 1993-07-09 Ab Astra New pharmaceutical formulation
ATE192932T1 (de) 1993-09-09 2000-06-15 Takeda Chemical Industries Ltd Formulierung enthaltend einen antibakteriellen und einen antiulcus wirkstoff
US5500227A (en) * 1993-11-23 1996-03-19 Euro-Celtique, S.A. Immediate release tablet cores of insoluble drugs having sustained-release coating
SE9402431D0 (sv) 1994-07-08 1994-07-08 Astra Ab New tablet formulation
US5888534A (en) * 1995-06-13 1999-03-30 Pentech Pharmaceuticals, Inc. Controlled release of drugs delivered by sublingual or buccal administration
SE9600072D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral formulation of two active ingredients II
JP3828648B2 (ja) 1996-11-14 2006-10-04 武田薬品工業株式会社 ２−（２−ピリジルメチルスルフィニル）ベンズイミダゾール系化合物の結晶およびその製造法
TW385306B (en) 1996-11-14 2000-03-21 Takeda Chemical Industries Ltd Method for producing crystals of benzimidazole derivatives
JP2762998B2 (ja) 1997-04-25 1998-06-11 武田薬品工業株式会社 医薬固形組成物用安定化剤および安定化方法
US6096340A (en) 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
WO1999027917A1 (de) * 1997-11-28 1999-06-10 Byk Gulden Lomberg Chemische Fabrik Gmbh Arzneimittelzubereitung in tabletten- oder pelletform für säurelabile wirkstoffe
EP1056456A4 (en) * 1998-01-30 2006-10-25 Sepracor Inc R-LANSOPRAZOL COMPOSITIONS AND TREATMENTS THEREFOR
JP4127740B2 (ja) 1998-04-20 2008-07-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 安定化したベンズイミダゾール系化合物含有組成物
ATE526022T1 (de) * 1998-04-20 2011-10-15 Eisai R&D Man Co Ltd Stabilisierte zusammenstellungen die benzimidazole enthalten
KR101032289B1 (ko) 1998-05-18 2011-05-06 다케다 야쿠힌 고교 가부시키가이샤 미세과립
ES2237121T3 (es) 1998-07-28 2005-07-16 Takeda Pharmaceutical Company Limited Preparacion solida disgregable rapidamente.
TW404832B (en) 1999-01-27 2000-09-11 Nang Kuang Pharmaceutical Co L The oral medicine with good stability cotaining the omeprazole or the analogues
TWI289557B (en) 1999-06-17 2007-11-11 Takeda Chemical Industries Ltd A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
EP1108425B1 (en) * 1999-12-16 2005-06-08 Laboratorio Medinfar-Produtos Farmaceuticos, S.A. New stable multi-unitary pharmaceutical preparations containing substituted benzimidazoles
AU2001252595A1 (en) 2000-04-28 2001-11-12 Takeda Chemical Industries Ltd. Process for producing optically active sulfoxide derivative
WO2004016242A2 (en) * 2002-08-16 2004-02-26 Themis Laboratories Private Limited A process for manufacture of stable oral multiple units pharamceutical composition containing benzimidazoles

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0237200A2 (en) * 1986-02-13 1987-09-16 Takeda Chemical Industries, Ltd. Use of basic inorganic salts of magnesium or calcium for the stabilisation of benzimidazole derivatives
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
EP0277741A1 (en) * 1987-01-29 1988-08-10 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
JPH05255088A (ja) * 1991-11-05 1993-10-05 Yoshitomi Pharmaceut Ind Ltd 抗潰瘍剤含有製剤
JPH05139964A (ja) * 1991-11-14 1993-06-08 Takada Seiyaku Kk 塩酸メキシレチン腸溶性製剤
JPH07223956A (ja) * 1994-02-09 1995-08-22 Taiyo Yakuhin Kogyo Kk 塩酸ニカルジピンの徐放剤用製剤およびこれを利用した徐放化製剤
JPH11139960A (ja) * 1997-09-05 1999-05-25 Takeda Chem Ind Ltd 医 薬

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004035052A1 (ja) * 2002-10-16 2004-04-29 Takeda Pharmaceutical Company Limited 安定な固形製剤
US9265730B2 (en) 2002-10-16 2016-02-23 Takeda Pharmaceutical Company Limited Stable solid preparations
US8697097B2 (en) 2002-10-16 2014-04-15 Takeda Pharmaceutical Company Limited Stable solid preparations
US8697094B2 (en) 2002-10-16 2014-04-15 Takeda Pharmaceutical Company Limited Stable solid preparations
US8449911B2 (en) 2003-03-12 2013-05-28 Takeda Pharmaceutical Company Limited Drug composition having active ingredient adhered at high concentration to spherical core
WO2004080439A1 (ja) * 2003-03-12 2004-09-23 Takeda Pharmaceutical Company Limited 高濃度に活性成分を球形核に付着させた医薬組成物
EP1602362A1 (en) * 2003-03-12 2005-12-07 Takeda Pharmaceutical Company Limited Drug composition having active ingredient adhered at high concentration to spherical core
EP1602362A4 (en) * 2003-03-12 2008-11-05 Takeda Pharmaceutical DRUG COMPOSITION COMPRISING AN ADHESIVE ACTIVE INGREDIENT IN HIGH CONCENTRATION TO A SPHERICAL CORE
WO2005025569A1 (en) * 2003-09-18 2005-03-24 Altana Pharma Ag Use of known active ingredients as radical scavengers
WO2005084649A1 (ja) * 2004-03-04 2005-09-15 Takeda Pharmaceutical Company Limited 安定なカプセル剤
JPWO2005084649A1 (ja) * 2004-03-04 2007-11-29 武田薬品工業株式会社 安定なカプセル剤
US8124780B2 (en) 2005-04-15 2012-02-28 Eisai R&D Management Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition
WO2006118017A1 (ja) * 2005-04-28 2006-11-09 Eisai R & D Management Co., Ltd. 安定化組成物

Also Published As

Publication number Publication date
US8105626B2 (en) 2012-01-31
EP1459737B1 (en) 2012-09-26
CA2463690C (en) 2011-08-23
ES2392960T3 (es) 2012-12-17
CN100562317C (zh) 2009-11-25
PT2258351E (pt) 2013-07-29
ES2426723T3 (es) 2013-10-24
EP2258351A3 (en) 2011-10-12
CY1113763T1 (el) 2016-07-27
CA2463690A1 (en) 2003-04-24
CY1114668T1 (el) 2016-10-05
US20050003005A1 (en) 2005-01-06
EP1459737A1 (en) 2004-09-22
EP1459737A4 (en) 2007-09-26
EP2258351B1 (en) 2013-06-19
DK2258351T3 (da) 2013-08-26
EP2258351A2 (en) 2010-12-08
CN1571659A (zh) 2005-01-26
DK1459737T3 (da) 2013-01-02
PT1459737E (pt) 2012-11-26

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