WO2003035790A9 - Improved method for generating an aerosol - Google Patents
Improved method for generating an aerosolInfo
- Publication number
- WO2003035790A9 WO2003035790A9 PCT/US2002/030871 US0230871W WO03035790A9 WO 2003035790 A9 WO2003035790 A9 WO 2003035790A9 US 0230871 W US0230871 W US 0230871W WO 03035790 A9 WO03035790 A9 WO 03035790A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- component
- aerosol
- solution
- liquid component
- particle size
- Prior art date
Links
- 239000000443 aerosol Substances 0.000 title claims abstract description 181
- 238000000034 method Methods 0.000 title claims abstract description 77
- 239000002245 particle Substances 0.000 claims abstract description 137
- 239000007788 liquid Substances 0.000 claims abstract description 117
- 238000009826 distribution Methods 0.000 claims abstract description 88
- 238000010438 heat treatment Methods 0.000 claims abstract description 25
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 48
- 238000009835 boiling Methods 0.000 claims description 23
- 239000003814 drug Substances 0.000 claims description 21
- 239000007787 solid Substances 0.000 claims description 19
- 210000004072 lung Anatomy 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 17
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 15
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 12
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims description 7
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims description 6
- 229960004436 budesonide Drugs 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 4
- UWHCKJMYHZGTIT-UHFFFAOYSA-N Tetraethylene glycol, Natural products OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 claims description 4
- 239000012080 ambient air Substances 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 4
- 229940055577 oleyl alcohol Drugs 0.000 claims description 4
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 4
- 230000000241 respiratory effect Effects 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 description 16
- 239000000463 material Substances 0.000 description 15
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 11
- 238000012387 aerosolization Methods 0.000 description 8
- ZQBAKBUEJOMQEX-UHFFFAOYSA-N phenyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OC1=CC=CC=C1 ZQBAKBUEJOMQEX-UHFFFAOYSA-N 0.000 description 8
- ZESRJSPZRDMNHY-YFWFAHHUSA-N 11-deoxycorticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 ZESRJSPZRDMNHY-YFWFAHHUSA-N 0.000 description 7
- ZESRJSPZRDMNHY-UHFFFAOYSA-N de-oxy corticosterone Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 ZESRJSPZRDMNHY-UHFFFAOYSA-N 0.000 description 7
- 229940119740 deoxycorticosterone Drugs 0.000 description 7
- 239000003570 air Substances 0.000 description 6
- 238000009833 condensation Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 208000007934 ACTH-independent macronodular adrenal hyperplasia Diseases 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 229960000969 phenyl salicylate Drugs 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 3
- WURBFLDFSFBTLW-UHFFFAOYSA-N benzil Chemical compound C=1C=CC=CC=1C(=O)C(=O)C1=CC=CC=C1 WURBFLDFSFBTLW-UHFFFAOYSA-N 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 229960004063 propylene glycol Drugs 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 206010006458 Bronchitis chronic Diseases 0.000 description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 2
- 206010014561 Emphysema Diseases 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical group NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 206010006451 bronchitis Diseases 0.000 description 2
- 208000007451 chronic bronchitis Diseases 0.000 description 2
- 238000010549 co-Evaporation Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000011364 vaporized material Substances 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 238000004164 analytical calibration Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002902 bimodal effect Effects 0.000 description 1
- OJIJEKBXJYRIBZ-UHFFFAOYSA-N cadmium nickel Chemical compound [Ni].[Cd] OJIJEKBXJYRIBZ-UHFFFAOYSA-N 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- -1 for example Chemical compound 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229910000953 kanthal Inorganic materials 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000723 toxicological property Toxicity 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
- A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/1075—Preparation of respiratory gases or vapours by influencing the temperature
- A61M16/109—Preparation of respiratory gases or vapours by influencing the temperature the humidifying liquid or the beneficial agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
- A61M11/007—Syringe-type or piston-type sprayers or atomisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0024—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with an on-off output signal, e.g. from a switch
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
Definitions
- the first component typically flows out of the outlet 25 of the flow passage 23 contemporaneously with the volatilized liquid component but can also flow out of the outlet 25 after the volatilized liquid flows out of the outlet.
- the contemporaneous flow of the first component and the liquid component out of the outlet 25 is referred to herein as "co-evaporation. " Achieving co-evaporation can depend on various parameters such as, for example, the types and amounts of the first component and liquid component that are used, the temperature of the flow passage 23 and the flow rate of the solution.
- a solution is prepared such that the amount of the first component therein is sufficient to achieve a predetermined particle size distribution of the first component and/or the liquid component upon aerosolization of the solution.
- the GSD of the particle size distribution of the first component can be less than or equal to about 2 such as, for example, from about 1.5 to 2.
- using a liquid component with a lower boiling point generally has the opposite effect, i.e., the particle size distribution of the first component typically becomes more bimodal and/or polydispersed upon aerosolization of the solution.
- some liquid components may not follow this trend, and while not wishing to be bound by theory, Applicants hypothesize that other properties such as physical and/or chemical properties of the liquid component also contribute to the particle size distribution and/or uniformity thereof.
- the liquid component preferably is aerosolized by heating the solution containing the liquid component to a temperature at or above the boiling point of the liquid component, for example at a temperature not less than 400 °C in certain applications.
- the temperature of the flow passage of the aerosol generator during aerosolization generally at least depends on the boiling point of the liquid component.
- the flow passage 23 preferably is of "capillary dimensions. " A flow passage of capillary dimensions permits volatilization of substantially all of the liquid present in the flow passage when the flow passage is heated. For example, the cross-sectional area of a flow passage of capillary dimensions typically is sufficiently small to enable the efficient heating of the solution present in the flow passage.
- the flow passage is formed of fused silica or an aluminum silicate.
- Other substantially non-reactive materials capable of withstanding repeated heating cycles and generated pressures and having suitable heat conduction properties can also be used such as, for example, stainless steel.
- the heater 27 is preferably an electrical resistance heater.
- the heater 27 is a heater wire having an outside diameter of 0.008 inches, a resistance of 13.1 ohms per foot, and a specific heat of 0.110 BTU/lb °F.
- the composition of the heater wire is preferably 71.7% iron, 23% chromium, and 5.3% aluminum.
- Such a heater wire is available from Kanthal Furnace Products, located in Bethel, Conn.
- the power supply 29 is sized to provide sufficient power for the heating element 27 that heats a portion or the entire flow passage 23.
- the power supply 29 is preferably replaceable and rechargeable and may include devices such as a capacitor and/or a battery.
- the power supply is, in a presently preferred embodiment, a replaceable, rechargeable battery such as four nickel cadmium battery cells connected in series with a total, non-loaded voltage of approximately 4.8 to 5.6 volts.
- the characteristics required of the power supply 29 are, however, selected in view of the characteristics of other components of the aerosol generator 21, particularly the characteristics of the heater 27.
- One power supply that has been found to operate successfully in generating an aerosol from liquid propylene glycol is operated continuously at approximately 2.5 Volts and 0.8 Amps.
- the aerosol can be generated intermittently, e.g., on demand, or continuously.
- the solution can be supplied to the portion of the flow passage 23 proximate the heater 27 each time that it is desired to generate an aerosol.
- the solution flows from a solution source 33 to a portion of the flow passage 23 proximate the heater 27, such as by being pumped by a pump 35 (shown by dotted lines).
- a pump 35 shown by dotted lines.
- Aerosols were generated from various solutions by introducing the solutions to an aerosol generator. The MMAD and GSD of the aerosols were measured to determine the effects of (1) varying the concentration of the first component in the solution and (2) varying the boiling point of the liquid component.
- the aerosol generator used in the examples includes a 26 gauge stainless steel capillary tube flow passage which had an inside diameter of 0.27 mm and a length of 44 mm.
- a syringe pump was used to supply the solution to the capillary tube flow passage.
- the syringe pump which was used was a Model 44 syringe pump, obtained from Harvard Apparatus located in South Natich, Massachusetts.
- the syringe needle that was used was a Microliter.No. 750, obtained from Hamilton Co. located in Reno, Nevada.
- a Model 6641 A D.C. power supply was used, obtained from Hewlett-Packard Co. located in Loveland, Colorado.
- a multi-function I/O electronic controller, obtained from Hewlett Packard, and an IBM Pentium II PC were also used.
- PhS phenyl salicylate
- DMSO and FORM each of which have boiling points that are higher than that of PG, yielded DOC/aerosol MMAD ratios (0.03 and 0.62, respectively) which were less than the DOC/aerosol MMAD ratio of PG. While not wishing to be bound by theory, Applicants believe that other characteristics of the liquid such as, for example, the chemical structure, had an effect on the solute and aerosol MMADs.
- FIG. 4 shows a graph of the DOC/total aerosol ratio as a function of the liquid component boiling point. It is apparent from FIG. 4 that using a liquid component having an increased boiling point generally had the effect of increasing the solute/aerosol MMAD ratio.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003538295A JP2005506886A (en) | 2001-10-19 | 2002-09-30 | Improved method for generating aerosols |
AT02802109T ATE554811T1 (en) | 2001-10-19 | 2002-09-30 | IMPROVED METHOD FOR GENERATING AEROSOL |
ES02802109T ES2386138T3 (en) | 2001-10-19 | 2002-09-30 | Improved method to generate a spray |
AU2002334717A AU2002334717A1 (en) | 2001-10-19 | 2002-09-30 | Improved method for generating an aerosol |
EP02802109A EP1441785B1 (en) | 2001-10-19 | 2002-09-30 | Improved method for generating an aerosol |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/981,739 US6883516B2 (en) | 2000-04-27 | 2001-10-19 | Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution |
US09/981,739 | 2001-10-19 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2003035790A2 WO2003035790A2 (en) | 2003-05-01 |
WO2003035790A3 WO2003035790A3 (en) | 2003-10-16 |
WO2003035790A9 true WO2003035790A9 (en) | 2004-12-29 |
Family
ID=25528617
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/030871 WO2003035790A2 (en) | 2001-10-19 | 2002-09-30 | Improved method for generating an aerosol |
Country Status (11)
Country | Link |
---|---|
US (1) | US6883516B2 (en) |
EP (1) | EP1441785B1 (en) |
JP (1) | JP2005506886A (en) |
AR (1) | AR036837A1 (en) |
AT (1) | ATE554811T1 (en) |
AU (1) | AU2002334717A1 (en) |
ES (1) | ES2386138T3 (en) |
MY (1) | MY128505A (en) |
PT (1) | PT1441785E (en) |
TW (1) | TW592796B (en) |
WO (1) | WO2003035790A2 (en) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
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US6766220B2 (en) * | 2001-07-31 | 2004-07-20 | Chrysalis Technologies Incorporated | Method and apparatus for generating a volatilized liquid |
DE60335401D1 (en) * | 2002-09-06 | 2011-01-27 | Philip Morris Usa Inc | AEROSOL PRODUCING DEVICES AND METHOD FOR PRODUCING AEROSOLS WITH CONTROLLED PARTICLE SIZES |
AU2003270320B2 (en) * | 2002-09-06 | 2008-10-23 | Philip Morris Products S.A. | Aerosol generating device and method of use thereof |
WO2004071491A1 (en) * | 2003-02-04 | 2004-08-26 | Chrysalis Technologies Incorporated | Aerosol formulations and aerosol delivery of buspirone, buprenorphine, triazolam, cyclobenzaprine and zolpidem |
CN100381083C (en) | 2003-04-29 | 2008-04-16 | 韩力 | Electronic nonflammable spraying cigarette |
WO2004112799A1 (en) * | 2003-06-13 | 2004-12-29 | Chrysalis Technologies Incorporated | Methods and apparatus for producing nanoscale particles |
WO2005037949A2 (en) * | 2003-10-07 | 2005-04-28 | Chrysalis Technologies Incorporated | Aerosol formulations of butalbital, lorazepam, ipratropium, baclofen, morphine and scopolamine |
US20050150489A1 (en) * | 2004-01-12 | 2005-07-14 | Steve Dunfield | Dispensing medicaments based on rates of medicament action |
US20060102175A1 (en) * | 2004-11-18 | 2006-05-18 | Nelson Stephen G | Inhaler |
US20090108090A1 (en) * | 2005-01-14 | 2009-04-30 | Cooper Environmental Services Llc | Quantitative aerosol generator (qag) |
US20080296400A1 (en) * | 2005-01-14 | 2008-12-04 | John Arthur Cooper | Quantitative aerosol generator (QAG) method and apparatus |
US7186958B1 (en) * | 2005-09-01 | 2007-03-06 | Zhao Wei, Llc | Inhaler |
US7987856B2 (en) | 2005-12-29 | 2011-08-02 | Philip Morris Usa Inc. | Smoking article with bypass channel |
US8240315B2 (en) * | 2005-12-29 | 2012-08-14 | Philip Morris Usa Inc. | Smoking article with improved delivery profile |
KR20090008277A (en) | 2006-03-28 | 2009-01-21 | 필립모리스 프로덕츠 에스.에이. | Smoking article with a restrictor |
US8353298B2 (en) * | 2006-07-12 | 2013-01-15 | Philip Morris Usa Inc. | Smoking article with impaction filter segment |
US8424539B2 (en) * | 2006-08-08 | 2013-04-23 | Philip Morris Usa Inc. | Smoking article with single piece restrictor and chamber |
US8235056B2 (en) * | 2006-12-29 | 2012-08-07 | Philip Morris Usa Inc. | Smoking article with concentric hollow core in tobacco rod and capsule containing flavorant and aerosol forming agents in the filter system |
TW200911141A (en) * | 2007-03-09 | 2009-03-16 | Philip Morris Prod | Super recessed filter cigarette restrictor |
TW200900014A (en) * | 2007-03-09 | 2009-01-01 | Philip Morris Prod | Smoking article filter with annular restrictor and downstream ventilation |
US20080216850A1 (en) * | 2007-03-09 | 2008-09-11 | Philip Morris Usa Inc. | Restrictor attachment for unfiltered smoking article |
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-
2001
- 2001-10-19 US US09/981,739 patent/US6883516B2/en not_active Expired - Lifetime
-
2002
- 2002-09-30 PT PT02802109T patent/PT1441785E/en unknown
- 2002-09-30 EP EP02802109A patent/EP1441785B1/en not_active Expired - Lifetime
- 2002-09-30 AU AU2002334717A patent/AU2002334717A1/en not_active Abandoned
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- 2002-09-30 WO PCT/US2002/030871 patent/WO2003035790A2/en active Application Filing
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- 2002-10-17 TW TW091123923A patent/TW592796B/en not_active IP Right Cessation
- 2002-10-18 MY MYPI20023903A patent/MY128505A/en unknown
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EP1441785B1 (en) | 2012-04-25 |
WO2003035790A2 (en) | 2003-05-01 |
EP1441785A2 (en) | 2004-08-04 |
WO2003035790A3 (en) | 2003-10-16 |
US20020078948A1 (en) | 2002-06-27 |
US6883516B2 (en) | 2005-04-26 |
ES2386138T3 (en) | 2012-08-10 |
JP2005506886A (en) | 2005-03-10 |
PT1441785E (en) | 2012-06-04 |
TW592796B (en) | 2004-06-21 |
AR036837A1 (en) | 2004-10-06 |
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