WO2003035891A3 - Method for formulating and immobilizing a protein matrix and a protein matrix for use in a sensor - Google Patents

Method for formulating and immobilizing a protein matrix and a protein matrix for use in a sensor Download PDF

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Publication number
WO2003035891A3
WO2003035891A3 PCT/US2002/030942 US0230942W WO03035891A3 WO 2003035891 A3 WO2003035891 A3 WO 2003035891A3 US 0230942 W US0230942 W US 0230942W WO 03035891 A3 WO03035891 A3 WO 03035891A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein matrix
protein
immobilizing
formulating
sensor
Prior art date
Application number
PCT/US2002/030942
Other languages
French (fr)
Other versions
WO2003035891A2 (en
Inventor
Rajiv Shah
Bahar Reghabi
Rudolph A Montalvo
Yanan Zhang
Original Assignee
Medtronic Minimed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Minimed Inc filed Critical Medtronic Minimed Inc
Priority to DE60226759T priority Critical patent/DE60226759D1/en
Priority to AU2002327774A priority patent/AU2002327774A1/en
Priority to CA002457545A priority patent/CA2457545A1/en
Priority to EP02763782A priority patent/EP1437937B1/en
Priority to JP2003538391A priority patent/JP2005507007A/en
Publication of WO2003035891A2 publication Critical patent/WO2003035891A2/en
Publication of WO2003035891A3 publication Critical patent/WO2003035891A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/817—Enzyme or microbe electrode

Abstract

A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.
PCT/US2002/030942 2001-10-23 2002-09-27 Method for formulating and immobilizing a protein matrix and a protein matrix for use in a sensor WO2003035891A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE60226759T DE60226759D1 (en) 2001-10-23 2002-09-27 Method for producing a sensor
AU2002327774A AU2002327774A1 (en) 2001-10-23 2002-09-27 Method for formulating and immobilizing a protein matrix and a protein matrix for use in a sensor
CA002457545A CA2457545A1 (en) 2001-10-23 2002-09-27 Method for formulating and immobilizing a protein matrix and a protein matrix for use in a sensor
EP02763782A EP1437937B1 (en) 2001-10-23 2002-09-27 Method for producing a sensor
JP2003538391A JP2005507007A (en) 2001-10-23 2002-09-27 Protein matrix formulation and immobilization method and protein matrix for use in sensors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33566301P 2001-10-23 2001-10-23
US60/335,663 2001-10-23
US10/033,723 US7192766B2 (en) 2001-10-23 2001-12-27 Sensor containing molded solidified protein
US10/033,723 2001-12-27

Publications (2)

Publication Number Publication Date
WO2003035891A2 WO2003035891A2 (en) 2003-05-01
WO2003035891A3 true WO2003035891A3 (en) 2003-11-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/030942 WO2003035891A2 (en) 2001-10-23 2002-09-27 Method for formulating and immobilizing a protein matrix and a protein matrix for use in a sensor

Country Status (8)

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US (4) US7192766B2 (en)
EP (1) EP1437937B1 (en)
JP (1) JP2005507007A (en)
AT (1) ATE396278T1 (en)
AU (1) AU2002327774A1 (en)
CA (1) CA2457545A1 (en)
DE (1) DE60226759D1 (en)
WO (1) WO2003035891A2 (en)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6535753B1 (en) 1998-08-20 2003-03-18 Microsense International, Llc Micro-invasive method for painless detection of analytes in extra-cellular space
US6338790B1 (en) 1998-10-08 2002-01-15 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
US6676816B2 (en) * 2001-05-11 2004-01-13 Therasense, Inc. Transition metal complexes with (pyridyl)imidazole ligands and sensors using said complexes
US8226814B2 (en) * 2001-05-11 2012-07-24 Abbott Diabetes Care Inc. Transition metal complexes with pyridyl-imidazole ligands
US8070934B2 (en) 2001-05-11 2011-12-06 Abbott Diabetes Care Inc. Transition metal complexes with (pyridyl)imidazole ligands
US6932894B2 (en) 2001-05-15 2005-08-23 Therasense, Inc. Biosensor membranes composed of polymers containing heterocyclic nitrogens
US7052591B2 (en) 2001-09-21 2006-05-30 Therasense, Inc. Electrodeposition of redox polymers and co-electrodeposition of enzymes by coordinative crosslinking
US7192766B2 (en) * 2001-10-23 2007-03-20 Medtronic Minimed, Inc. Sensor containing molded solidified protein
US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
US7699964B2 (en) 2004-02-09 2010-04-20 Abbott Diabetes Care Inc. Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
US8165651B2 (en) 2004-02-09 2012-04-24 Abbott Diabetes Care Inc. Analyte sensor, and associated system and method employing a catalytic agent
US7545272B2 (en) 2005-02-08 2009-06-09 Therasense, Inc. RF tag on test strips, test strip vials and boxes
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
US9968742B2 (en) 2007-08-29 2018-05-15 Medtronic Minimed, Inc. Combined sensor and infusion set using separated sites
US20120046533A1 (en) 2007-08-29 2012-02-23 Medtronic Minimed, Inc. Combined sensor and infusion sets
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8206353B2 (en) * 2008-04-11 2012-06-26 Medtronic Minimed, Inc. Reservoir barrier layer systems and methods
US9295776B2 (en) * 2008-04-11 2016-03-29 Medtronic Minimed, Inc. Reservoir plunger head systems and methods
US8858501B2 (en) * 2008-04-11 2014-10-14 Medtronic Minimed, Inc. Reservoir barrier layer systems and methods
AU2009295960A1 (en) 2008-09-29 2010-04-01 Cardiaq Valve Technologies, Inc. Heart valve
EP2341871B1 (en) 2008-10-01 2017-03-22 Edwards Lifesciences CardiAQ LLC Delivery system for vascular implant
US8394463B1 (en) 2009-01-23 2013-03-12 Medtronic Minimed, Inc. Crosslinking compounds at negative pressures and materials made by such methods
AU2010236288A1 (en) 2009-04-15 2011-10-20 Cardiaq Valve Technologies, Inc. Vascular implant and delivery system
US20110082356A1 (en) 2009-10-01 2011-04-07 Medtronic Minimed, Inc. Analyte sensor apparatuses having interference rejection membranes and methods for making and using them
US20110288388A1 (en) 2009-11-20 2011-11-24 Medtronic Minimed, Inc. Multi-conductor lead configurations useful with medical device systems and methods for making and using them
US20120148850A1 (en) * 2009-11-24 2012-06-14 Yongwoo Lee Sorption reinforced catalytic coating system and method for the degradation of threat agents
US8660628B2 (en) 2009-12-21 2014-02-25 Medtronic Minimed, Inc. Analyte sensors comprising blended membrane compositions and methods for making and using them
US10448872B2 (en) 2010-03-16 2019-10-22 Medtronic Minimed, Inc. Analyte sensor apparatuses having improved electrode configurations and methods for making and using them
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US9215995B2 (en) 2010-06-23 2015-12-22 Medtronic Minimed, Inc. Sensor systems having multiple probes and electrode arrays
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9008744B2 (en) 2011-05-06 2015-04-14 Medtronic Minimed, Inc. Method and apparatus for continuous analyte monitoring
US9493807B2 (en) 2012-05-25 2016-11-15 Medtronic Minimed, Inc. Foldover sensors and methods for making and using them
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US20140012115A1 (en) 2012-07-03 2014-01-09 Medtronic Minimed, Inc. Plasma deposited adhesion promoter layers for use with analyte sensors
US10194840B2 (en) 2012-12-06 2019-02-05 Medtronic Minimed, Inc. Microarray electrodes useful with analyte sensors and methods for making and using them
US10426383B2 (en) 2013-01-22 2019-10-01 Medtronic Minimed, Inc. Muting glucose sensor oxygen response and reducing electrode edge growth with pulsed current plating
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US20150122647A1 (en) 2013-11-07 2015-05-07 Medtronic Minimed, Inc. Enzyme matrices for use with ethylene oxide sterilization
CN105899132B (en) 2013-12-31 2020-02-18 雅培糖尿病护理公司 Self-powered analyte sensor and devices using same
US10245034B2 (en) * 2015-08-31 2019-04-02 Ethicon Llc Inducing tissue adhesions using surgical adjuncts and medicants
US10569071B2 (en) 2015-08-31 2020-02-25 Ethicon Llc Medicant eluting adjuncts and methods of using medicant eluting adjuncts
US10324058B2 (en) 2016-04-28 2019-06-18 Medtronic Minimed, Inc. In-situ chemistry stack for continuous glucose sensors
FI3455269T3 (en) 2016-05-10 2023-11-30 Evonik Canada Inc Implantable glucose sensors having a biostable surface
US11298059B2 (en) 2016-05-13 2022-04-12 PercuSense, Inc. Analyte sensor
US11179078B2 (en) 2016-06-06 2021-11-23 Medtronic Minimed, Inc. Polycarbonate urea/urethane polymers for use with analyte sensors
CN110023745B (en) * 2016-12-09 2022-08-23 东北大学 Robust enzyme-based biosensor and droplet deposition immobilization method
US11134868B2 (en) 2017-03-17 2021-10-05 Medtronic Minimed, Inc. Metal pillar device structures and methods for making and using them in electrochemical and/or electrocatalytic applications
US10856784B2 (en) 2017-06-30 2020-12-08 Medtronic Minimed, Inc. Sensor initialization methods for faster body sensor response
US20190223771A1 (en) 2018-01-23 2019-07-25 Medtronic Minimed, Inc. Implantable polymer surfaces exhibiting reduced in vivo inflammatory responses
US11186859B2 (en) 2018-02-07 2021-11-30 Medtronic Minimed, Inc. Multilayer electrochemical analyte sensors and methods for making and using them
US11583213B2 (en) 2018-02-08 2023-02-21 Medtronic Minimed, Inc. Glucose sensor electrode design
US11220735B2 (en) 2018-02-08 2022-01-11 Medtronic Minimed, Inc. Methods for controlling physical vapor deposition metal film adhesion to substrates and surfaces
WO2019222499A1 (en) 2018-05-16 2019-11-21 Medtronic Minimed, Inc. Thermally stable glucose limiting membrane for glucose sensors
US11718865B2 (en) 2019-07-26 2023-08-08 Medtronic Minimed, Inc. Methods to improve oxygen delivery to implantable sensors
US11523757B2 (en) 2019-08-01 2022-12-13 Medtronic Minimed, Inc. Micro-pillar working electrodes design to reduce backflow of hydrogen peroxide in glucose sensor
US20220031205A1 (en) 2020-07-31 2022-02-03 Medtronic Minimed, Inc. Sensor identification and integrity check design
US20220133190A1 (en) 2020-10-29 2022-05-05 Medtronic Minimed, Inc. Glucose biosensors comprising direct electron transfer enzymes and methods of making and using them
US20220240823A1 (en) 2021-01-29 2022-08-04 Medtronic Minimed, Inc. Interference rejection membranes useful with analyte sensors
US20220338768A1 (en) 2021-04-09 2022-10-27 Medtronic Minimed, Inc. Hexamethyldisiloxane membranes for analyte sensors
US20230053254A1 (en) 2021-08-13 2023-02-16 Medtronic Minimed, Inc. Dry electrochemical impedance spectroscopy metrology for conductive chemical layers
US20230113175A1 (en) 2021-10-08 2023-04-13 Medtronic Minimed, Inc. Immunosuppressant releasing coatings
US20230123613A1 (en) 2021-10-14 2023-04-20 Medtronic Minimed, Inc. Sensors for 3-hydroxybutyrate detection
US20230172497A1 (en) 2021-12-02 2023-06-08 Medtronic Minimed, Inc. Ketone limiting membrane and dual layer membrane approach for ketone sensing
US20240023849A1 (en) 2022-07-20 2024-01-25 Medtronic Minimed, Inc. Acrylate hydrogel membrane for dual function of diffusion limiting membrane as well as attenuation to the foreign body response

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6171586B1 (en) * 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US6267958B1 (en) * 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US426638A (en) * 1890-04-29 Belt rest
US424696A (en) * 1890-04-01 Fan-blower
CH564031A5 (en) * 1968-03-29 1975-07-15 Anvar
US4240438A (en) 1978-10-02 1980-12-23 Wisconsin Alumni Research Foundation Method for monitoring blood glucose levels and elements
US4486408A (en) 1981-04-07 1984-12-04 Kiel Johnathan L Insoluble crosslinked cytotoxic oxidase-peroxidase system
US4478946A (en) 1981-07-02 1984-10-23 South African Inventions Development Corporation Carrier bound immunosorbent
US4568335A (en) 1981-08-28 1986-02-04 Markwell Medical Institute, Inc. Device for the controlled infusion of medications
US4628928A (en) 1982-08-09 1986-12-16 Medtronic, Inc. Robotic implantable medical device and/or component restoration system
US4771772A (en) 1982-08-09 1988-09-20 Medtronic, Inc. Robotic implantable medical device and/or component restoration system
US4479796A (en) 1982-11-15 1984-10-30 Medtronic, Inc. Self-regenerating drug administration device
US4650547A (en) 1983-05-19 1987-03-17 The Regents Of The University Of California Method and membrane applicable to implantable sensor
US4484987A (en) 1983-05-19 1984-11-27 The Regents Of The University Of California Method and membrane applicable to implantable sensor
JPS60260611A (en) 1984-06-08 1985-12-23 Mitsubishi Petrochem Co Ltd Production of high-molecular weight cresol novolak resin
US4890620A (en) 1985-09-20 1990-01-02 The Regents Of The University Of California Two-dimensional diffusion glucose substrate sensing electrode
US4757022A (en) 1986-04-15 1988-07-12 Markwell Medical Institute, Inc. Biological fluid measuring device
US4994167A (en) 1986-04-15 1991-02-19 Markwell Medical Institute, Inc. Biological fluid measuring device
US4703756A (en) 1986-05-06 1987-11-03 The Regents Of The University Of California Complete glucose monitoring system with an implantable, telemetered sensor module
US4891104A (en) * 1987-04-24 1990-01-02 Smithkline Diagnostics, Inc. Enzymatic electrode and electrode module and method of use
FR2617763B1 (en) * 1987-07-07 1989-12-01 Essilor Int METHOD OF MANUFACTURING CONTACT LENS IN A NATURAL PROTEIN POLYMER, BY MOLDING BEFORE CROSS-LINKING
JP2672561B2 (en) * 1988-01-29 1997-11-05 テルモ株式会社 Membrane cover sensor
US5266688A (en) 1988-06-21 1993-11-30 Chiron Corporation Polynucleotide sequence for production of glucose oxidase in recombinant systems
US5094951A (en) 1988-06-21 1992-03-10 Chiron Corporation Production of glucose oxidase in recombinant systems
US4911168A (en) 1989-01-13 1990-03-27 Pacesetter Infusion, Ltd. Method of screening and selecting intraperitoneal medication infusion pump candidates
US5270446A (en) 1989-04-04 1993-12-14 Suntory Limited Decolorized crosslinked products and method for decolorization of crosslinked products
US5431160A (en) * 1989-07-19 1995-07-11 University Of New Mexico Miniature implantable refillable glucose sensor and material therefor
US5985129A (en) 1989-12-14 1999-11-16 The Regents Of The University Of California Method for increasing the service life of an implantable sensor
US5593852A (en) 1993-12-02 1997-01-14 Heller; Adam Subcutaneous glucose electrode
US5773270A (en) 1991-03-12 1998-06-30 Chiron Diagnostics Corporation Three-layered membrane for use in an electrochemical sensor system
US5328460A (en) 1991-06-21 1994-07-12 Pacesetter Infusion, Ltd. Implantable medication infusion pump including self-contained acoustic fault detection apparatus
GB9311784D0 (en) 1993-06-08 1993-07-28 Univ Alberta Vascular bioartificial organ
US5497772A (en) 1993-11-19 1996-03-12 Alfred E. Mann Foundation For Scientific Research Glucose monitoring system
US5791344A (en) 1993-11-19 1998-08-11 Alfred E. Mann Foundation For Scientific Research Patient monitoring system
US5494562A (en) 1994-06-27 1996-02-27 Ciba Corning Diagnostics Corp. Electrochemical sensors
US5667983A (en) 1994-10-24 1997-09-16 Chiron Diagnostics Corporation Reagents with enhanced performance in clinical diagnostic systems
US5741319A (en) 1995-01-27 1998-04-21 Medtronic, Inc. Biocompatible medical lead
US5995860A (en) 1995-07-06 1999-11-30 Thomas Jefferson University Implantable sensor and system for measurement and control of blood constituent levels
US5741211A (en) 1995-10-26 1998-04-21 Medtronic, Inc. System and method for continuous monitoring of diabetes-related blood constituents
DE69633573T2 (en) 1995-11-22 2005-10-06 Medtronic MiniMed, Inc., Northridge DETECTION OF BIOLOGICAL MOLECULES USING CHEMICAL AMPLIFICATION AND OPTICAL SENSOR
US6002954A (en) 1995-11-22 1999-12-14 The Regents Of The University Of California Detection of biological molecules using boronate-based chemical amplification and optical sensors
SE9504233D0 (en) 1995-11-27 1995-11-27 Pacesetter Ab Implantable medical device
US5834232A (en) * 1996-05-01 1998-11-10 Zymogenetics, Inc. Cross-linked gelatin gels and methods of making them
CA2259254C (en) 1996-07-08 2008-02-19 Animas Corporation Implantable sensor and system for in vivo measurement and control of fluid constituent levels
JP2943700B2 (en) 1996-07-10 1999-08-30 日本電気株式会社 Biosensor
US5707502A (en) 1996-07-12 1998-01-13 Chiron Diagnostics Corporation Sensors for measuring analyte concentrations and methods of making same
US5696314A (en) 1996-07-12 1997-12-09 Chiron Diagnostics Corporation Multilayer enzyme electrode membranes and methods of making same
US5804048A (en) 1996-08-15 1998-09-08 Via Medical Corporation Electrode assembly for assaying glucose
US5932175A (en) 1996-09-25 1999-08-03 Via Medical Corporation Sensor apparatus for use in measuring a parameter of a fluid sample
DE69735127T2 (en) 1996-11-14 2006-08-31 Radiometer Medical Aps ENZYME SENSOR
US5964993A (en) * 1996-12-19 1999-10-12 Implanted Biosystems Inc. Glucose sensor
JP3394262B2 (en) 1997-02-06 2003-04-07 セラセンス、インク． Small volume in vitro analyte sensor
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US6093167A (en) 1997-06-16 2000-07-25 Medtronic, Inc. System for pancreatic stimulation and glucose measurement
US5919216A (en) 1997-06-16 1999-07-06 Medtronic, Inc. System and method for enhancement of glucose production by stimulation of pancreatic beta cells
US6134459A (en) 1998-10-30 2000-10-17 Medtronic, Inc. Light focusing apparatus for medical electrical lead oxygen sensor
US6198952B1 (en) 1998-10-30 2001-03-06 Medtronic, Inc. Multiple lens oxygen sensor for medical electrical lead
US6125291A (en) 1998-10-30 2000-09-26 Medtronic, Inc. Light barrier for medical electrical lead oxygen sensor
US6248080B1 (en) 1997-09-03 2001-06-19 Medtronic, Inc. Intracranial monitoring and therapy delivery control device, system and method
US6125290A (en) 1998-10-30 2000-09-26 Medtronic, Inc. Tissue overgrowth detector for implantable medical device
US6144866A (en) 1998-10-30 2000-11-07 Medtronic, Inc. Multiple sensor assembly for medical electric lead
US6259937B1 (en) * 1997-09-12 2001-07-10 Alfred E. Mann Foundation Implantable substrate sensor
AU9599498A (en) 1997-09-30 1999-04-23 M-Biotech, Inc. Biosensor
US5941906A (en) 1997-10-15 1999-08-24 Medtronic, Inc. Implantable, modular tissue stimulator
US6027479A (en) 1998-02-27 2000-02-22 Via Medical Corporation Medical apparatus incorporating pressurized supply of storage liquid
US6103033A (en) 1998-03-04 2000-08-15 Therasense, Inc. Process for producing an electrochemical biosensor
US5992211A (en) 1998-04-23 1999-11-30 Medtronic, Inc. Calibrated medical sensing catheter system
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US5934232A (en) 1998-06-12 1999-08-10 General Motors Corporation Engine valve lift mechanism
JP2002518135A (en) 1998-06-23 2002-06-25 サージカル シーランツ， インコーポレイテッド Carbodiimide cross-linked albumin for bioadhesive surgical sealants and implantable devices
US6280587B1 (en) 1998-07-02 2001-08-28 Nec Corporation Enzyme electrode and a biosensor and a measuring apparatus therewith
US6251260B1 (en) 1998-08-24 2001-06-26 Therasense, Inc. Potentiometric sensors for analytic determination
US6159240A (en) 1998-08-31 2000-12-12 Medtronic, Inc. Rigid annuloplasty device that becomes compliant after implantation
US6201980B1 (en) 1998-10-05 2001-03-13 The Regents Of The University Of California Implantable medical sensor system
US6163723A (en) 1998-10-22 2000-12-19 Medtronic, Inc. Circuit and method for implantable dual sensor medical electrical lead
US6261280B1 (en) 1999-03-22 2001-07-17 Medtronic, Inc Method of obtaining a measure of blood glucose
USD424696S (en) 1999-05-06 2000-05-09 Therasense, Inc. Glucose sensor
USD426638S (en) 1999-05-06 2000-06-13 Therasense, Inc. Glucose sensor buttons
US6368274B1 (en) 1999-07-01 2002-04-09 Medtronic Minimed, Inc. Reusable analyte sensor site and method of using the same
US6343225B1 (en) * 1999-09-14 2002-01-29 Implanted Biosystems, Inc. Implantable glucose sensor
EP1373889A2 (en) 2000-07-31 2004-01-02 Maxygen, Inc. Biosensors, reagents and diagnostic applications of directed evolution
US7192766B2 (en) * 2001-10-23 2007-03-20 Medtronic Minimed, Inc. Sensor containing molded solidified protein

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6267958B1 (en) * 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US6171586B1 (en) * 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation

Also Published As

Publication number Publication date
EP1437937A2 (en) 2004-07-21
JP2005507007A (en) 2005-03-10
DE60226759D1 (en) 2008-07-03
CA2457545A1 (en) 2003-05-01
AU2002327774A1 (en) 2003-05-06
US7192766B2 (en) 2007-03-20
ATE396278T1 (en) 2008-06-15
EP1437937A4 (en) 2005-11-30
US7435569B2 (en) 2008-10-14
US20050006807A1 (en) 2005-01-13
EP1437937B1 (en) 2008-05-21
WO2003035891A2 (en) 2003-05-01
US20030077772A1 (en) 2003-04-24
US8187851B2 (en) 2012-05-29
US20050214741A1 (en) 2005-09-29
US8137927B2 (en) 2012-03-20
US20090081753A1 (en) 2009-03-26

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