WO2003040319A2 - Endothelial cells derived from primate embryonic stem cells - Google Patents
Endothelial cells derived from primate embryonic stem cells Download PDFInfo
- Publication number
- WO2003040319A2 WO2003040319A2 PCT/US2002/035278 US0235278W WO03040319A2 WO 2003040319 A2 WO2003040319 A2 WO 2003040319A2 US 0235278 W US0235278 W US 0235278W WO 03040319 A2 WO03040319 A2 WO 03040319A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cells
- endothelial
- endothelial cells
- embryonic stem
- culture
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002356896A AU2002356896B2 (en) | 2001-11-02 | 2002-11-01 | Endothelial cells derived from primate embryonic stem cells |
CA2465173A CA2465173C (en) | 2001-11-02 | 2002-11-01 | Endothelial cells derived from primate embryonic stem cells |
IL16146102A IL161461A0 (en) | 2001-11-02 | 2002-11-01 | Endothelial cells derived from primate embryonic stem cells |
JP2003542566A JP4085062B2 (en) | 2001-11-02 | 2002-11-01 | Endothelial cells derived from primate embryonic stem cells |
MXPA04004067A MXPA04004067A (en) | 2001-11-02 | 2002-11-01 | Endothelial cells derived from primate embryonic stem cells. |
BR0213815-8A BR0213815A (en) | 2001-11-02 | 2002-11-01 | Endothelial cells derived from primate embryonic stem cells |
EP02802833A EP1446476A4 (en) | 2001-11-02 | 2002-11-01 | Endothelial cells derived from primate embryonic stem cells |
LU91074A LU91074B1 (en) | 2001-11-02 | 2002-11-01 | Endothelial cells derived from primate embryonic stem cells |
NZ532170A NZ532170A (en) | 2001-11-02 | 2002-11-01 | Endothelial cells derived from primate embryonic stem cells |
IL161461A IL161461A (en) | 2001-11-02 | 2004-04-15 | Endothelial cells derived from primate embryonic stem cells |
IS7242A IS7242A (en) | 2001-11-02 | 2004-04-30 | Internal epithelial cells derived from embryonic primate cells |
SE0401132A SE529427C8 (en) | 2001-11-02 | 2004-05-03 | Method for preparation of endothelial cells from primate embryonic stem cells |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33533201P | 2001-11-02 | 2001-11-02 | |
US60/335,332 | 2001-11-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003040319A2 true WO2003040319A2 (en) | 2003-05-15 |
WO2003040319A3 WO2003040319A3 (en) | 2003-10-23 |
Family
ID=23311328
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/035278 WO2003040319A2 (en) | 2001-11-02 | 2002-11-01 | Endothelial cells derived from primate embryonic stem cells |
Country Status (15)
Country | Link |
---|---|
US (1) | US7176023B2 (en) |
EP (1) | EP1446476A4 (en) |
JP (1) | JP4085062B2 (en) |
KR (1) | KR20050042215A (en) |
CN (1) | CN100540657C (en) |
AU (1) | AU2002356896B2 (en) |
BR (1) | BR0213815A (en) |
CA (1) | CA2465173C (en) |
IL (2) | IL161461A0 (en) |
IS (1) | IS7242A (en) |
LU (1) | LU91074B1 (en) |
MX (1) | MXPA04004067A (en) |
NZ (1) | NZ532170A (en) |
SE (1) | SE529427C8 (en) |
WO (1) | WO2003040319A2 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1783207A1 (en) * | 2004-06-22 | 2007-05-09 | Tanabe Seiyaku Co., Ltd. | Method of producing vascular endothelial cells from primate embryonic stem cells |
EP2277993A1 (en) * | 2008-03-19 | 2011-01-26 | Obshhestvo S Ogranichennojj Otvetstvennost' Ju "Laboratorija Kletochnykh Tekhnologijj" | Method for producing endothelial cells (variants) |
US20110312018A1 (en) * | 2006-06-23 | 2011-12-22 | Shusta Eric V | Blood-Brain Barrier Model |
US20120009618A1 (en) * | 2010-07-07 | 2012-01-12 | Cellular Dynamics International, Inc. | Endothelial cell production by programming |
CN102719393A (en) * | 2012-06-05 | 2012-10-10 | 中山大学 | Serum-free medium capable of inducing tumor stem cells for differentiation towards lymphatic endothelial cells, and method for inducing tumor stem cells for differentiation towards lymphatic endothelial cells |
US8507275B2 (en) | 2008-02-18 | 2013-08-13 | Korea Advanced Institute Of Science And Technology (Kaist) | Method of inducing differentiation of embryonic stem cells into hemangioblast |
US9580682B1 (en) | 2015-08-12 | 2017-02-28 | Korea University Research And Business Foundation | Method for inducing endodermal and mesodermal differentiation from human pluripotent stem cells by CXCR2 suppression |
CN115316589A (en) * | 2021-03-30 | 2022-11-11 | 云南师范大学 | Method for removing agglutinin in stem and leaf of pseudo-ginseng |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003080801A2 (en) * | 2002-03-19 | 2003-10-02 | Advanced Research & Technology Transfer | Adipose stromal stem cells for tissue and vascular modification |
US20040009589A1 (en) * | 2002-03-26 | 2004-01-15 | Shulamit Levenberg | Endothelial cells derived from human embryonic stem cells |
JP5630781B2 (en) | 2006-04-14 | 2014-11-26 | アドバンスド セル テクノロジー、インコーポレイテッド | Hemangio-colony forming cells |
KR100986149B1 (en) * | 2007-09-14 | 2010-10-07 | 차의과학대학교 산학협력단 | A process for the differentiation of vascular endothelial progenitor cells from embryoid bodies derived from embryonic stem cells using hypoxic media condition |
JP5748654B2 (en) | 2008-05-06 | 2015-07-15 | オカタ セラピューティクス, インコーポレイテッド | Method for producing enucleated red blood cells derived from pluripotent stem cells |
CA2802087A1 (en) | 2010-06-15 | 2011-12-22 | Cellular Dynamics International, Inc. | A compendium of ready-built stem cell models for interrogation of biological response |
US20120295347A1 (en) * | 2011-05-20 | 2012-11-22 | Steven Kessler | Methods and Compositions for Producing Endothelial Progenitor Cells from Pluripotent Stem Cells |
EP2934555B1 (en) | 2012-12-21 | 2021-09-22 | Astellas Institute for Regenerative Medicine | Methods for production of platelets from pluripotent stem cells |
CN103194423B (en) * | 2013-03-07 | 2015-02-25 | 中国人民解放军军事医学科学院野战输血研究所 | Medium and purpose thereof |
US10794801B2 (en) * | 2013-05-13 | 2020-10-06 | Konica Minolta, Inc. | Cell staining method and sample collection tube used for the same |
US10961531B2 (en) | 2013-06-05 | 2021-03-30 | Agex Therapeutics, Inc. | Compositions and methods for induced tissue regeneration in mammalian species |
US11078462B2 (en) | 2014-02-18 | 2021-08-03 | ReCyte Therapeutics, Inc. | Perivascular stromal cells from primate pluripotent stem cells |
US10240127B2 (en) | 2014-07-03 | 2019-03-26 | ReCyte Therapeutics, Inc. | Exosomes from clonal progenitor cells |
CA3173124A1 (en) * | 2020-04-06 | 2021-10-14 | Kyle M. LOH | Generating populations of human blood and blood vessel progenitors from pluripotent stem cells |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5612211A (en) | 1990-06-08 | 1997-03-18 | New York University | Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors |
CZ307995A3 (en) | 1993-05-24 | 1996-10-16 | Immunex Corp | Ligands for flt3 receptors |
JPH078273A (en) * | 1993-06-14 | 1995-01-13 | Kurabo Ind Ltd | Serumfree culture of adhesive animal cell |
EP0757562A1 (en) * | 1994-04-29 | 1997-02-12 | W.L. Gore & Associates, Inc. | Improved blood contact surfaces using endothelium on a subendothelial extracellular matrix |
US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
AU3392697A (en) | 1996-06-14 | 1998-01-07 | Regents Of The University Of California, The | (in vitro) derivation and culture of primate pluripotent stem cells and therapeutic uses thereof |
-
2002
- 2002-11-01 JP JP2003542566A patent/JP4085062B2/en not_active Expired - Lifetime
- 2002-11-01 CN CNB028219708A patent/CN100540657C/en not_active Expired - Lifetime
- 2002-11-01 US US10/287,334 patent/US7176023B2/en not_active Expired - Lifetime
- 2002-11-01 LU LU91074A patent/LU91074B1/en active
- 2002-11-01 CA CA2465173A patent/CA2465173C/en not_active Expired - Lifetime
- 2002-11-01 WO PCT/US2002/035278 patent/WO2003040319A2/en active Application Filing
- 2002-11-01 NZ NZ532170A patent/NZ532170A/en not_active IP Right Cessation
- 2002-11-01 MX MXPA04004067A patent/MXPA04004067A/en active IP Right Grant
- 2002-11-01 IL IL16146102A patent/IL161461A0/en unknown
- 2002-11-01 EP EP02802833A patent/EP1446476A4/en not_active Withdrawn
- 2002-11-01 AU AU2002356896A patent/AU2002356896B2/en not_active Expired
- 2002-11-01 BR BR0213815-8A patent/BR0213815A/en not_active Application Discontinuation
- 2002-11-01 KR KR1020047006549A patent/KR20050042215A/en not_active Application Discontinuation
-
2004
- 2004-04-15 IL IL161461A patent/IL161461A/en active IP Right Grant
- 2004-04-30 IS IS7242A patent/IS7242A/en unknown
- 2004-05-03 SE SE0401132A patent/SE529427C8/en not_active IP Right Cessation
Non-Patent Citations (2)
Title |
---|
PAPADIMITRIOU E. ET AL.: 'Endothelial cell proliferation induced by HARP: implication of N or C terminal peptides' BIOCHEM. AND BIOPHYS. RES. COMM. vol. 274, 21 July 2000, pages 242 - 248, XP002965721 * |
See also references of EP1446476A2 * |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1783207A4 (en) * | 2004-06-22 | 2008-07-30 | Mitsubishi Tanabe Pharma Corp | Method of producing vascular endothelial cells from primate embryonic stem cells |
EP1783207A1 (en) * | 2004-06-22 | 2007-05-09 | Tanabe Seiyaku Co., Ltd. | Method of producing vascular endothelial cells from primate embryonic stem cells |
US8293495B2 (en) * | 2006-06-23 | 2012-10-23 | Wisconsin Alumni Research Foundation | Blood-brain barrier model |
US20110312018A1 (en) * | 2006-06-23 | 2011-12-22 | Shusta Eric V | Blood-Brain Barrier Model |
US8507275B2 (en) | 2008-02-18 | 2013-08-13 | Korea Advanced Institute Of Science And Technology (Kaist) | Method of inducing differentiation of embryonic stem cells into hemangioblast |
EP2277993A1 (en) * | 2008-03-19 | 2011-01-26 | Obshhestvo S Ogranichennojj Otvetstvennost' Ju "Laboratorija Kletochnykh Tekhnologijj" | Method for producing endothelial cells (variants) |
EP2277993A4 (en) * | 2008-03-19 | 2011-11-09 | Obshhestvo S Ogranichennojj Otvetstvennost Ju Lab Kletochnykh T | Method for producing endothelial cells (variants) |
US8785192B2 (en) * | 2010-07-07 | 2014-07-22 | Cellular Dynamics International, Inc. | Endothelial cell production by programming |
US20120009618A1 (en) * | 2010-07-07 | 2012-01-12 | Cellular Dynamics International, Inc. | Endothelial cell production by programming |
US9404122B2 (en) | 2010-07-07 | 2016-08-02 | Cellular Dynamics International, Inc. | Endothelial cell production by programming |
CN102719393A (en) * | 2012-06-05 | 2012-10-10 | 中山大学 | Serum-free medium capable of inducing tumor stem cells for differentiation towards lymphatic endothelial cells, and method for inducing tumor stem cells for differentiation towards lymphatic endothelial cells |
US9580682B1 (en) | 2015-08-12 | 2017-02-28 | Korea University Research And Business Foundation | Method for inducing endodermal and mesodermal differentiation from human pluripotent stem cells by CXCR2 suppression |
CN115316589A (en) * | 2021-03-30 | 2022-11-11 | 云南师范大学 | Method for removing agglutinin in stem and leaf of pseudo-ginseng |
Also Published As
Publication number | Publication date |
---|---|
CN1582331A (en) | 2005-02-16 |
AU2002356896B2 (en) | 2007-11-01 |
SE0401132D0 (en) | 2004-05-03 |
US7176023B2 (en) | 2007-02-13 |
JP4085062B2 (en) | 2008-04-30 |
MXPA04004067A (en) | 2004-07-08 |
NZ532170A (en) | 2008-05-30 |
US20030166273A1 (en) | 2003-09-04 |
CA2465173A1 (en) | 2003-05-15 |
SE529427C8 (en) | 2007-09-25 |
KR20050042215A (en) | 2005-05-06 |
LU91074B1 (en) | 2004-04-30 |
SE529427C2 (en) | 2007-08-07 |
WO2003040319A3 (en) | 2003-10-23 |
EP1446476A2 (en) | 2004-08-18 |
IL161461A (en) | 2010-11-30 |
IL161461A0 (en) | 2004-09-27 |
SE0401132L (en) | 2004-05-03 |
EP1446476A4 (en) | 2005-01-26 |
IS7242A (en) | 2004-04-30 |
JP2005508180A (en) | 2005-03-31 |
CA2465173C (en) | 2010-04-20 |
CN100540657C (en) | 2009-09-16 |
BR0213815A (en) | 2004-10-19 |
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