WO2003041793A2 - Cardiac lead with steroid eluting ring - Google Patents
Cardiac lead with steroid eluting ring Download PDFInfo
- Publication number
- WO2003041793A2 WO2003041793A2 PCT/US2002/034975 US0234975W WO03041793A2 WO 2003041793 A2 WO2003041793 A2 WO 2003041793A2 US 0234975 W US0234975 W US 0234975W WO 03041793 A2 WO03041793 A2 WO 03041793A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lead
- recited
- ring
- cardiac
- cardiac lead
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/056—Transvascular endocardial electrode systems
- A61N1/057—Anchoring means; Means for fixing the head inside the heart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/056—Transvascular endocardial electrode systems
- A61N1/0565—Electrode heads
- A61N1/0568—Electrode heads with drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/056—Transvascular endocardial electrode systems
- A61N1/057—Anchoring means; Means for fixing the head inside the heart
- A61N1/0573—Anchoring means; Means for fixing the head inside the heart chacterised by means penetrating the heart tissue, e.g. helix needle or hook
- A61N1/0575—Anchoring means; Means for fixing the head inside the heart chacterised by means penetrating the heart tissue, e.g. helix needle or hook with drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Electrotherapy Devices (AREA)
Abstract
A cardiac lead is disclosed which includes an elongated lead body having opposed proximal and distal ends, a tip electrode operatively associated with the distal end of the elongated lead body, a connector operatively associated with the proximal end of the elongated lead body and electrically connected to the tip electrode, and a cylindrical eluting ring disposed proximate the tip electrode and formed from a compound including an elastomer and about 15% to 25% by weight medicament.
Description
CARDIAC LEAD WITH STEROID ELUTING RING CROSS-REFERENCE TO RELATED APPLICATIONS The subject application claims the benefit of priority to U.S. Provisional
Patent Application Serial No. 60/344,984 filed November 9, 2001, the disclosure of which is herein incorporated by reference in its entirety. BACKGROUND OF THE INVENTION
1. Field of the Invention The subject invention is directed to cardiac leads, and more particularly, to passive and active unipolar, bipolar, tripolar and quadrupolar endocardial stimulation leads that are adapted and configured to elute a steroid to treat cardiac tissue.
2. Background of the Related Art Implantable cardiac stimulation leads, including endocardial leads, are well known in the art. In general, these devices have an elongated flexible body with an electrode at one end for contacting cardiac tissue and a connector at the other end for mating with an automated stimulation device, namely a pacemaker or defibrillator. The electrode of an endocardial lead may be secured within a chamber of the heart by passive fixation through the use of a plurality of flexible tines which project outwardly from the end of the lead body, or by active fixation through the use of a helical fixation screw.
When an endocardial lead has been implanted in the heart, either by active or passive fixation, it has been determined that the cardiac tissue at the site of implantation will react favorably to the lead in the presence of a therapeutic drug,
such as, for example, a steroid. Consequently, cardiac leads have been designed with means for delivering a therapeutic drug to the cardiac tissue at the implantation site.
One such example of a lead having drug delivery means is disclosed in U.S. Patent No. 5,902,330 to Ollivier et al. which describes a pacing lead having a frusto-conical diffusion ring fixed in place by gluing. The diffusion ring is constructed of porous silicone and loaded with an active material, such as a steroid, for distributing the steroid in the region of the myocardium adjacent the electrode. Another example of a drug delivery device is disclosed in U.S. Patent No. 6,361,780 to Ley et al. which describes a microporous bio-compatible collar or annulus having a therapeutic drug within its pores. The collar or annulus is preferably formed from a ceramic material and is designed to surround a portion of a lead or catheter.
SUMMARY OF THE INVENTION
The subject invention is directed to a new and useful cardiac lead that includes an elongated flexible lead body having opposed proximal and distal ends. A tip electrode is operatively associated with the distal end of the elongated lead body, and a connector is operatively associated with the proximal end of the elongated lead body. The connector is electrically connected to the tip electrode by a conductor coil that extends through the interior of the lead body.
A cylindrical eluting ring or collar surrounds the distal tip electrode. The eluting ring is formed from a compound that includes an elastomer and about 15% to 25% by weight medicament. The elastomer is preferably silicone and the
medicament is preferably a steroid, and more preferably, either dexamethasone sodium phosphate or dexamethasone sodium acetate. Other steroids may also be employed.
In one embodiment of the subject invention, the lead is adapted for active fixation and includes a retractable fixation screw operatively associated with a distal end portion of the lead body. In another embodiment of the subject invention, the lead is adapted for passive fixation and includes a plurality of flexible tines associated with a distal end portion of the lead body. In yet another embodiment of the subject invention, the lead is adapted for bipolar stimulation and includes a ring electrode spaced from the tip electrode and electrically associated with the connector. In other embodiments of the subject invention, the lead is adapted for defibrillation as well as pacing/sensing. In such instances, the lead may be tripolar or quadrupolar, and may be adapted for passive or active fixation. These and other aspects of the cardiac lead of the subject invention will become more readily apparent to those having ordinary skill in the art from the following detailed description of the invention taken in conjunction with the drawings described hereinbelow.
BREIF DESCRIPTION OF THE DRAWINGS
So that those having ordinary skill in the art to which the subject invention pertains will more readily understand how to make and use the cardiac leads of the subject invention, embodiments thereof will be described in detail hereinbelow with reference to the drawings, wherein:
Fig. 1 is a perspective view ofa steroid eluting unipolar active fixation lead constructed in accordance with a preferred embodiment of the subject invention;
Fig. 2 is a side elevational view of the distal portion of the unipolar active fixation lead of Fig. 1; Fig. 3 is a cross-sectional view of the distal portion of the steroid eluting unipolar active fixation lead of Fig. 1;
Fig. 4 is a side elevational view of the distal portion of a steroid eluting bipolar active fixation lead constructed in accordance with a preferred embodiment of the subject invention; Fig. 5 is a cross-sectional view of the distal portion of the steroid eluting bipolar active fixation lead of Fig. 4;
Fig. 6 is a side elevational view of the distal portion of a steroid eluting unipolar passive fixation lead constructed in accordance with a preferred embodiment of the subject invention; Fig. 7 is a cross-sectional view of the distal portion of the steroid eluting unipolar passive fixation lead of Fig. 6;
Fig. 8 is a side elevational view of the distal portion ofa steroid eluting bipolar passive fixation lead constructed in accordance with a preferred embodiment of the subject invention; Fig. 9 is a cross-sectional view of the distal portion of the steroid eluting bipolar passive fixation lead of Fig. 8;
Fig. 10 is a side elevational view of the distal portion ofa steroid eluting tripolar passive fixation lead constructed in accordance with a preferred embodiment of the subject invention; and
Fig. 11 is a side elevational view of the distal portion ofa steroid eluting quadrupolar passive fixation lead constructed in accordance with a preferred embodiment of the subject invention.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
Referring now to the drawings wherein like reference numerals identify similar aspects of the cardiac leads of the subject invention, there is illustrated in Fig. 1 a unipolar active fixation lead constructed in accordance with a preferred embodiment the subject invention and designated generally by reference numeral 10. Cardiac lead 10 includes an elongated flexible lead body 12 having opposed proximal and distal ends. The lead body 12 is formed from a bio-compatible insulative material such as silicone rubber, polyurethane or the like.
With continuing reference to Fig. 1, a tip electrode 14 with an annular contact surface is operatively associated with the distal end of the elongated lead body 12. The tip electrode 14 is coated with or formed from platinum, stainless steel MP35N, a platinum-iridium alloy or a similar material. A comiector 16 is operatively associated with the proximal end of the elongated lead body 12. The connector 16 may be of any standard type, size or configuration such as, for example, an IS-1 type connector (International Standard ISO 5841.3:1992). This type of connector may be employed for both unipolar and bipolar pacing/sensing. Comiector 16 is electrically connected to the tip electrode 14 by way of a conductor coil 18 that extends through the interior lumen of lead body 12. Conductor coil 18 is generally helical in configuration and includes one or more conductive wires or filaments. For example, the conductor may be a multifilar
conductor coil with as many as eight (8) filaments. Other conductors may be employed such as flexible low-ohm DFT drawn filled rope tubing.
As best seen in Figs. 2 and 3, a cylindrical ring or collar 20 is disposed at the distal end of lead body 12 proximate to or surrounding at least a portion of tip electrode 14. Ring 20 is a therapeutic drug eluting structure that is formed from a compound that includes an elastomer, such as silicone and about 15% to 25% by weight medicament. Preferably, the medicament is a steroid. However, other therapeutic drugs or agents may be employed. In use, the steroid elutes from the elastomer over time having a desirable effect on surrounding cardiac tissue. Suitable steroids include dexamethasone sodium phosphate and dexamethasone sodium acetate. Other steroids may also be used.
Preferably, eluting ring 20 has an axial length of about 1 to 2mm, and a durometer of about 65 to 90 Shore A. Those skilled in the art will readily appreciate that the geometry and dimensions of the ring may be modified to control the rate at which the steroid is eluted from the silicone. Eluting ring 20 is formed by mixing liquid silicone rubber (LSR) together with the steroid. The composition is then extruded into a tubular form and subsequently cut into rings having a desired length. Alternatively, the composition may be used to mold rings ofa desired length. In either instance, after formation, the ring is then glued in place using a silicone adhesive.
The following table sets forth the calculated weight (considering tolerances in tubing diameter and density measurements) of dexamethasone sodium phosphate per ring (based on a ring length of 1.1 ± 0.1 mm) from three different
lots of rings formed from a compound containing 19.41% by weight dexamethasone sodium phosphate and 80.59% by weight silicone.
With continuing reference to Fig. 2, cardiac lead 10 includes a fixation screw 22 which is operatively associated with the distal end of lead body 12 for actively securing the lead tip to the myocardium during implantation. Fixation screw 22 is defined by a wire helix may be manipulated through use of the screw driver stylet 24 primarily illustrated in Fig. 1, the distal end of which is shown in Fig. 3. The fixation screw may be electrically active to assist in pacing/sensing. Other retraction/extension mechanism are also envisioned. For example, the fixation screw could be retracted/extended by turning one helical coil relative to another coil.
Referring now to Figs. 4 and 5, there is illustrated another cardiac lead constructed in accordance with a preferred embodiment of the subject invention and designated generally by reference numeral 100. Cardiac lead 100 is substantially identical to cardiac lead 10 in that it has an active fixation screw 122 and a silicone eluting ring 120 containing about 15% to 25% by weight steroid. Cardiac lead 100 differs however from cardiac lead 10 in that it is adapted for bipolar pacing/sensing rather than unipolar pacing. More particularly, cardiac lead 100 includes both a distal tip electrode 114 which defines a cathodic pole and a ring electrode 126 spaced proximally from tip electrode 114 and defining an anodic pole.
As best seen in Fig. 5, an inner conductor coil 118 is operatively associated with the distal tip electrode 114 for delivering energy to the tip electrode from the connector at the proximal end of the elongated flexible lead body 112. Similarly, an outer conductor coil 128 is operatively associated with the ring electrode 126 for delivering energy to the ring electrode from the connector at the proximal end of the lead body 112. A sheath 130 or similar structure provides a layer of insulation between the inner and outer conductor coils. Alternative wiring arrangements are also envisioned, including multifilar coils in which one or more wires of the coil are connected to each electrode and are separated from one another by an insulating material.
Referring to Figs. 6 and 7, there is illustrated another cardiac lead constructed in accordance with a preferred embodiment of the subject invention and designated generally by reference numeral 200. Cardiac lead 200 is substantially identical to cardiac lead 10 in that it includes a distal tip electrode 214 receiving energy from a coiled conductor 218 and surrounded by a silicone eluting ring 220 containing about 15% to 25% by weight steroid. Cardiac lead 200 differs however from cardiac lead 10 in that cardiac lead 200 is adapted for passive fixation rather than active fixation. More particularly, cardiac lead 200 includes a plurality of outwardly projecting flexible tines 230 rather than a helical fixation screw.
The flexible tines 230 of cardiac lead 200 are formed from silicone rubber and are adapted to keep the lead tip securely anchored within the trabeculae of the heart, and more particularly, within the right ventricle. It is also envisioned that the distal portion of the lead can have a preformed J-shaped configuration so that it
may be employed in the right atrium. During implantation, when cardiac lead 200 is introduced into the myocardium within the lumen of a catheter or introducer sheath, the flexible tines 230 deflect into an axially extended position within a circumferential recessed area 232 formed in the distal portion of lead body 212. As a result, the profile of the lead body is substantially uniform.
Referring to Figs. 8 and 9, there is illustrated another cardiac lead constructed in accordance with a preferred embodiment of the subject invention and designated generally by reference numeral 300. Cardiac lead 300 is substantially identical to cardiac lead 200 in that it has a plurality of outwardly projecting flexible tines 330 adapted to facilitate passive fixation of the lead tip, and a silicone eluting ring 320 containing about 15% to 25% by weight steroid. Cardiac lead 300 differs however from cardiac lead 200 in that it is adapted for bipolar pacing/sensing rather than unipolar pacing. Thus, cardiac lead 300 includes a cathodic distal tip electrode 314 and an anodic proximal ring electrode 326. An inner conductor coil 318 is operatively associated with the distal tip electrode 314, and an outer conductor coil 328 is operatively associated with the proximal ring electrode 326.
Referring now to Fig. 10, there is illustrated another cardiac lead constructed in accordance with a preferred embodiment of the subject invention and designated generally by reference numeral 400. Cardiac lead 400 is a tripolar lead in that it includes a cathodic distal tip electrode 414 and an anodic proximal ring electrode 426 which are used for pacing/sensing, and a shocking coil 450 that is used for right ventricular defibrillation. In this tripolar configuration, shocking coil 450 serves as a ground. Like each of the other embodiment disclosed herein,
cardiac lead 400 includes a silicone eluting ring 420 containing about 15% to 25% by weight steroid. As illustrated, lead 400 has outwardly projecting flexible tines 430 adapted to facilitate passive fixation, but the lead can include an active fixation screw as illustrated for example in Fig. 2. While not shown, the proximal portion of lead 400 is preferably bifurcated and includes a bipolar IS-1 type connector associated with electrodes 414 and 426, and a unipolar DF-1 type connector (International Standard ISO 11318:1993) associated with shocking coil 450.
Referring to Fig. 11, there is illustrated yet another cardiac lead constructed in accordance with a preferred embodiment of the subject invention and designated generally by reference numeral 500. Cardiac lead 500 is a quadrupolar lead in that it includes a cathodic distal tip electrode 514 and an anodic proximal ring electrode 526 which are used for pacing/sensing, and two shocking coils 550 and 552 that are used for defibrillation. More particularly, the distal shocking coil 550 is used for right ventricular stimulation while the proximal shocking coil 552 is used to stimulate the superior vena cava. In certain circumstances, cardiac lead 500 may be employed in such a manner so that the distal shocking coil 550 serves normally as a pacing/sensing anode, but during defibrillation it serves as a shocking coil.
Cardiac lead 500 includes a silicone eluting ring 520 containing about 15% to 25% by weight steroid. The lead is shown with outwardly projecting flexible tines 530, but an active fixation screw may be employed. The proximal portion of lead 500 is preferably trifurcated in that it includes a bipolar IS-1 type connector associated with electrodes 514 and 526, a first unipolar DF-1 type connector associated with distal shocking coil 550, and a second unipolar DF-1 type connector associated with proximal shocking coil 552.
Although the subject invention have been described with respect to preferred embodiments, those skilled in the art will readily appreciate that changes and modifications may be made thereto without departing from the spirit and scope of the subject invention as defined by the appended claims.
Claims
1. A cardiac lead comprising: a) an elongated lead body having opposed proximal and distal ends; b) an annular tip electrode operatively associated with the distal end of the elongated lead body; c) a connector operatively associated with the proximal end of the elongated lead body and electrically connected to the tip electrode; and d) a cylindrical eluting ring surrounding the tip electrode and formed from a compound including an elastomer and about 15% to 25% by weight medicament.
2. A cardiac lead as recited in Claim 1, wherein the lead is adapted for active fixation and includes a retractable fixation screw operatively associated with a distal end portion of the lead body.
3. A cardiac lead as recited in Claim 1, wherein the lead is adapted for passive fixation and includes a plurality of flexible tines associated with a distal end portion of the lead body.
4. A cardiac lead as recited in Claim 1, wherein the lead is adapted for bipolar stimulation and includes a ring electrode spaced proximalfy from the tip electrode and electrically connected to the connector.
5. A cardiac lead as recited in Claim 1, wherein the compound from which the eluting ring is formed includes silicone and about 15% to 25% by weight medicament.
6. A cardiac lead as recited in Claim 1, wherein the compound from which the eluting ring is formed includes an elastomer and about 15% to 25% by weight steroid.
7. A cardiac lead as recited in Claim 1, wherein the compound from which the eluting ring is formed includes silicone and about 15% to 25% by weight dexamethasone sodium phosphate.
8. A cardiac lead as recited in Claim 1, wherein the compound from which the eluting ring is formed includes silicone and about 15% to 25% by weight dexamethasone sodium acetate. .
9. A cardiac lead as recited in Claim 1, wherein the eluting ring has an axial length of about 1mm to 2mm.
10. A cardiac lead as recited in Claim 1, wherein the eluting ring has a durometer of about 65 to 90 Shore A.
11. A cardiac lead as recited in Claim 1 , further comprising a conductor coil extending through the lead body for electrically connecting the tip electrode to the connector.
12. A cardiac lead configured for passive fixation comprising: a) an elongated lead body having opposed proximal and distal ends; b) an annular tip electrode operatively associated with the distal end of the elongated lead body; c) a plurality of flexible tines associated with a distal portion of the lead body d) a connector operatively associated with the proximal end of the elongated lead body and electrically connected to the tip electrode; and e) a cylindrical eluting ring surrounding the tip electrode and formed from a compound including an elastomer and about 15% to 25% by weight medicament.
13. A cardiac lead as recited in Claim 12, wherein the lead is adapted for bipolar stimulation and includes a ring electrode spaced proximally from the tip electrode and electrically connected to the connector.
14. A cardiac lead as recited in Claim 12, wherein the compound from which the eluting ring is formed includes silicone and about 15% to 25% by weight dexamethasone sodium phosphate.
15. A cardiac lead as recited in Claim 12, wherein the compound from which the eluting ring is foπned includes silicone and about 15% to 25% by weight dexamethasone sodium acetate.
16. A cardiac lead as recited in Claim 12, wherein the eluting ring has an axial length of about 1mm to 2mm.
17. A cardiac lead as recited in Claim 12, wherein the eluting ring has a durometer of about 65 to 90 Shore A.
18. A cardiac lead as recited in Claim 12, further comprising a conductor coil extending through the lead body for electrically connecting the tip electrode and the connector.
19. A cardiac lead as recited in Claim 13, further comprising at least one multifilar conductor coil extending through the lead body for electrically connecting the tip electrode and the ring electrode to the connector.
20. A cardiac lead configured for active fixation comprising: a) an elongated lead body having opposed proximal and distal ends; b) an annular tip electrode operatively associated with the distal end of the elongated lead body; c) a retractable fixation screw operatively associated with a distal portion of the lead body d) a connector operatively associated with the proximal end of the elongated lead body and electrically connected to the tip electrode; and e) a cylindrical eluting ring surrounding the tip electrode and formed from a compound including an elastomer and about 15% to 25% by weight medicament.
21. A cardiac lead as recited in Claim 20, wherein the lead is adapted for bipolar stimulation and includes a ring electrode spaced from the tip electrode and electrically connected to the connector.
22. A cardiac lead as recited in Claim 20, wherein the compound from which the eluting ring is formed includes silicone and about 15% to 25% by weight dexamethasone sodium phosphate.
23. A cardiac lead as recited in Claim 20, wherein the compound from which the eluting ring is formed includes silicone and about 15% to 25% by weight dexamethasone sodium acetate.
24. A cardiac lead as recited in Claim 20, wherein the eluting ring has an axial length of about 1mm to 2mm.
25. A cardiac lead as recited in Claim 20, wherein the eluting ring has a durometer of about 65 to 90 Shore A.
26. A cardiac lead as recited in Claim 20, further comprising a conductor coil extending through the lead body for electrically connecting the tip electrode and the connector.
27. A cardiac lead as recited in Claim 21, further comprising at least one multifilar conductor coil extending through the lead body for electrically connecting the tip electrode and the ring electrode to the connector.
28. A cardiac lead configured for bipolar stimulation comprising: a) an elongated lead body having opposed proximal and distal ends; b) a cathodic tip electrode operatively associated with the distal end of the elongated lead body; c) an anodic ring electrode spaced proximally from the tip electrode; d) a connector operatively associated with the proximal end of the elongated lead body and electrically connected to the tip electrode and the ring electrode; and e) a cylindrical eluting ring disposed proximate to the tip electrode and formed from a compound including an elastomer and about 15% to 25% by weight medicament.
29. A cardiac lead as recited in Claim 28, wherein the lead is adapted for active fixation and includes a retractable fixation screw operatively associated with a distal end portion of the lead body.
30. A cardiac lead as recited in Claim 28, wherein the lead is adapted for passive fixation and includes a plurality of flexible tines associated with a distal end portion of the lead body.
31. A cardiac lead as recited in Claim 28, wherein the compound from which the eluting ring is formed includes silicone and about 15% to 25% by weight dexamethasone sodium phosphate.
32. A cardiac lead as recited in Claim 28, wherein the compound from which the eluting ring is formed includes silicone and about 15% to 25% by weight dexamethasone sodium acetate.
33. A cardiac lead as recited in Claim 28, wherein the eluting ring has an axial length of about 1mm to 2mm.
34. A cardiac lead as recited in Claim 28, wherein the eluting ring has a durometer of about 65 to 90 Shore A.
35. A cardiac lead as recited in Claim 28, wherein the connector is an IS-1 type connector.
36. A cardiac lead as recited in Claim 28, further comprising at least one multifilar conductor coil extending through the lead body for electrically connecting the tip electrode and the ring electrode to the connector.
37. A cardiac lead as recited in Claim 28, further comprising at least one defibrillation coil spaced proximally from the ring electrode.
38. A cardiac lead as recited in Claim 37, further comprising at least one additional connector operatively associated with the proximal end of the elongated lead body and electrically connected to the at least one defibrillation coil.
39. A cardiac lead as recited in Claim 38, wherein the connector is a DF-1 type connector.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02789350A EP1441806A2 (en) | 2001-11-09 | 2002-11-01 | Cardiac lead with steroid eluting ring |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34498401P | 2001-11-09 | 2001-11-09 | |
US60/344,984 | 2001-11-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003041793A2 true WO2003041793A2 (en) | 2003-05-22 |
WO2003041793A3 WO2003041793A3 (en) | 2003-10-30 |
Family
ID=23352950
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/034975 WO2003041793A2 (en) | 2001-11-09 | 2002-11-01 | Cardiac lead with steroid eluting ring |
PCT/US2002/034974 WO2003041792A2 (en) | 2001-11-09 | 2002-11-01 | High impedance drug eluting cardiac lead |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/034974 WO2003041792A2 (en) | 2001-11-09 | 2002-11-01 | High impedance drug eluting cardiac lead |
Country Status (3)
Country | Link |
---|---|
US (2) | US6671562B2 (en) |
EP (2) | EP1441806A2 (en) |
WO (2) | WO2003041793A2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007115044A2 (en) * | 2006-03-31 | 2007-10-11 | Boston Scientific Scimed, Inc. | Cardiac stimulation electrodes, delivery devices, and implantation configuration |
US9308374B2 (en) | 2006-07-21 | 2016-04-12 | Boston Scientific Scimed, Inc. | Delivery of cardiac stimulation devices |
US9545513B2 (en) | 2004-10-20 | 2017-01-17 | Cardiac Pacemakers, Inc. | Leadless cardiac stimulation systems |
US9956401B2 (en) | 2006-09-13 | 2018-05-01 | Boston Scientific Scimed, Inc. | Cardiac stimulation using intravascularly-deliverable electrode assemblies |
US10022538B2 (en) | 2005-12-09 | 2018-07-17 | Boston Scientific Scimed, Inc. | Cardiac stimulation system |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7013182B1 (en) * | 2000-05-04 | 2006-03-14 | Cardiac Pacemakers, Inc. | Conductive polymer sheath on defibrillator shocking coils |
US7155294B2 (en) * | 2003-06-26 | 2006-12-26 | Medtronic, Inc. | Conductor arrangement for multipolar medical electrical leads |
US7155292B2 (en) * | 2003-09-25 | 2006-12-26 | Cardiac Pacemakers, Inc. | Active fixation assembly for an implantable device |
US7225024B2 (en) * | 2003-09-30 | 2007-05-29 | Cardiac Pacemakers, Inc. | Sensors having protective eluting coating and method therefor |
US7953499B2 (en) * | 2003-09-30 | 2011-05-31 | Cardiac Pacemakers, Inc. | Drug-eluting electrode |
US20050165452A1 (en) * | 2004-01-28 | 2005-07-28 | Medtronic, Inc. | Antithrombogenic medical device |
US7844344B2 (en) | 2004-03-30 | 2010-11-30 | Medtronic, Inc. | MRI-safe implantable lead |
US20050228469A1 (en) * | 2004-04-12 | 2005-10-13 | Cardiac Pacemakers, Inc. | Electrode and conductor interconnect and method therefor |
US20050246007A1 (en) * | 2004-04-28 | 2005-11-03 | Medtronic, Inc. | Novel lead body assemblies |
FR2869807B1 (en) * | 2004-05-05 | 2007-03-09 | Marc Bemurat | BIPOLAR CARDIAC STIMULATION PROBE WITH AUXILIARY POLE |
US8219212B2 (en) * | 2004-08-23 | 2012-07-10 | Medtronic, Inc. | Distal portions for medical electrical leads |
US20060041297A1 (en) * | 2004-08-23 | 2006-02-23 | Medtronic, Inc. | Novel electrode assembly for medical electrical leads |
US20060235499A1 (en) * | 2005-04-14 | 2006-10-19 | Cardiac Pacemakers, Inc. | Coated lead fixation electrode |
US20060247753A1 (en) * | 2005-04-29 | 2006-11-02 | Wenger William K | Subcutaneous lead fixation mechanisms |
US20070060332A1 (en) * | 2005-08-15 | 2007-03-15 | Anderson Peter R | Gaming machine having additional features for tracked players |
US20070051531A1 (en) * | 2005-09-08 | 2007-03-08 | Harshad Borgaonkar | Drug eluting coatings for a medical lead and method therefor |
US20070179582A1 (en) * | 2006-01-31 | 2007-08-02 | Marshall Mark T | Polymer reinforced coil conductor for torque transmission |
US7881808B2 (en) * | 2006-03-29 | 2011-02-01 | Cardiac Pacemakers, Inc. | Conductive polymeric coating with optional biobeneficial topcoat for a medical lead |
US20070255368A1 (en) * | 2006-04-28 | 2007-11-01 | Bonde Eric H | Implantable medical electrical stimulation lead with distal fixation and method |
US7610101B2 (en) * | 2006-11-30 | 2009-10-27 | Cardiac Pacemakers, Inc. | RF rejecting lead |
US20080183187A1 (en) | 2007-01-30 | 2008-07-31 | Cardiac Pacemakers, Inc. | Direct delivery system for transvascular lead |
US8244378B2 (en) | 2007-01-30 | 2012-08-14 | Cardiac Pacemakers, Inc. | Spiral configurations for intravascular lead stability |
US20080183255A1 (en) * | 2007-01-30 | 2008-07-31 | Cardiac Pacemakers, Inc. | Side port lead delivery system |
US7949409B2 (en) * | 2007-01-30 | 2011-05-24 | Cardiac Pacemakers, Inc. | Dual spiral lead configurations |
US20080183264A1 (en) * | 2007-01-30 | 2008-07-31 | Cardiac Pacemakers, Inc. | Electrode configurations for transvascular nerve stimulation |
US7917230B2 (en) * | 2007-01-30 | 2011-03-29 | Cardiac Pacemakers, Inc. | Neurostimulating lead having a stent-like anchor |
US9044593B2 (en) | 2007-02-14 | 2015-06-02 | Medtronic, Inc. | Discontinuous conductive filler polymer-matrix composites for electromagnetic shielding |
US8483842B2 (en) | 2007-04-25 | 2013-07-09 | Medtronic, Inc. | Lead or lead extension having a conductive body and conductive body contact |
US20090024197A1 (en) * | 2007-07-18 | 2009-01-22 | Cardiac Pacemakers, Inc. | Elution control via geometric features of an implantable substance matrix |
US20090099612A1 (en) * | 2007-10-15 | 2009-04-16 | Armstrong Julie S | Electrical conductor having a bioerodible coating |
US20090259280A1 (en) * | 2007-10-15 | 2009-10-15 | Kevin Wilkin | Electrical stimulation lead with bioerodible anchors and anchor straps |
EP2207588B1 (en) * | 2007-10-16 | 2016-11-16 | Cardiac Pacemakers, Inc. | Stimulation and sensing lead wtih non-coiled wire construction |
US8731685B2 (en) * | 2007-12-06 | 2014-05-20 | Cardiac Pacemakers, Inc. | Implantable lead having a variable coil conductor pitch |
WO2009079037A1 (en) | 2007-12-14 | 2009-06-25 | Cardiac Pacemakers, Inc. | Fixation helix and multipolar medical electrode |
JP5149399B2 (en) | 2008-02-06 | 2013-02-20 | カーディアック ペースメイカーズ, インコーポレイテッド | Lead with design features compatible with MRI |
US9037263B2 (en) | 2008-03-12 | 2015-05-19 | Medtronic, Inc. | System and method for implantable medical device lead shielding |
US8103360B2 (en) | 2008-05-09 | 2012-01-24 | Foster Arthur J | Medical lead coil conductor with spacer element |
WO2010047893A1 (en) * | 2008-10-23 | 2010-04-29 | Cardiac Pacemakers, Inc. | Systems and methods to detect implantable medical device configuration changes affecting mri conditional safety |
EP2370152B1 (en) | 2008-11-20 | 2014-04-09 | Cardiac Pacemakers, Inc. | Overmolded components for implantable medical leads and related methods |
US20100137927A1 (en) * | 2008-12-01 | 2010-06-03 | Tengiz Tkebuchava | Multifunctional cardiac pacemaker system |
JP5638003B2 (en) | 2009-01-12 | 2014-12-10 | ユニバーシティ オブ マサチューセッツ ローウェル | Polyisobutylene polyurethane |
WO2010104643A2 (en) | 2009-03-12 | 2010-09-16 | Cardiac Pacemakers, Inc. | Thin profile conductor assembly for medical device leads |
US8788061B2 (en) | 2009-04-30 | 2014-07-22 | Medtronic, Inc. | Termination of a shield within an implantable medical lead |
EP2429636B1 (en) * | 2009-04-30 | 2014-08-27 | Medtronic, Inc | Shielding an implantable medical lead |
EP2429651B1 (en) | 2009-04-30 | 2018-10-24 | Medtronic, Inc. | Detection of proper insertion of medical leads into a medical device |
ES2547713T3 (en) * | 2009-06-26 | 2015-10-08 | Cardiac Pacemakers, Inc. | Bypass of a medical device that includes a single-coil coil with improved torque transmission capacity and reduced RM heating |
JP5602859B2 (en) | 2009-08-21 | 2014-10-08 | カーディアック ペースメイカーズ, インコーポレイテッド | POLYISOBUTYLENE-BASED CROSSLINKABLE POLYMER AND MEDICAL DEVICE CONTAINING THE SAME |
US8374704B2 (en) | 2009-09-02 | 2013-02-12 | Cardiac Pacemakers, Inc. | Polyisobutylene urethane, urea and urethane/urea copolymers and medical leads containing the same |
US8644952B2 (en) | 2009-09-02 | 2014-02-04 | Cardiac Pacemakers, Inc. | Medical devices including polyisobutylene based polymers and derivatives thereof |
US8753708B2 (en) | 2009-09-02 | 2014-06-17 | Cardiac Pacemakers, Inc. | Solventless method for forming a coating on a medical electrical lead body |
US8335572B2 (en) * | 2009-10-08 | 2012-12-18 | Cardiac Pacemakers, Inc. | Medical device lead including a flared conductive coil |
WO2011043898A2 (en) * | 2009-10-09 | 2011-04-14 | Cardiac Pacemakers, Inc. | Mri compatible medical device lead including transmission line notch filters |
US9254380B2 (en) | 2009-10-19 | 2016-02-09 | Cardiac Pacemakers, Inc. | MRI compatible tachycardia lead |
WO2011081701A1 (en) * | 2009-12-30 | 2011-07-07 | Cardiac Pacemakers, Inc. | Implantable electrical lead including a cooling assembly to dissipate mri induced electrode heat |
EP2519311A1 (en) * | 2009-12-30 | 2012-11-07 | Cardiac Pacemakers, Inc. | Mri-conditionally safe medical device lead |
JP2013516222A (en) * | 2009-12-30 | 2013-05-13 | カーディアック ペースメイカーズ, インコーポレイテッド | Tapered drug-eluting color for medical electrical leads |
US8391994B2 (en) | 2009-12-31 | 2013-03-05 | Cardiac Pacemakers, Inc. | MRI conditionally safe lead with low-profile multi-layer conductor for longitudinal expansion |
CN102655908B (en) | 2009-12-31 | 2015-04-22 | 心脏起搏器公司 | MRI conditionally safe lead with multi-layer conductor |
US8825181B2 (en) | 2010-08-30 | 2014-09-02 | Cardiac Pacemakers, Inc. | Lead conductor with pitch and torque control for MRI conditionally safe use |
US10500394B1 (en) | 2011-10-11 | 2019-12-10 | A-Hamid Hakki | Pacemaker system equipped with a flexible intercostal generator |
US9289593B1 (en) | 2011-10-11 | 2016-03-22 | A-Hamid Hakki | Endovascular electrode system for tissue stimulation |
US9775991B1 (en) | 2011-10-11 | 2017-10-03 | A-Hamid Hakki | Endovascular electrode system for tissue stimulation with embedded generator |
AU2012333113B2 (en) | 2011-11-04 | 2014-11-20 | Cardiac Pacemakers, Inc. | Implantable medical device lead including inner coil reverse-wound relative to shocking coil |
WO2013158189A1 (en) | 2012-04-19 | 2013-10-24 | Medtronic, Inc. | Paired medical lead bodies with braided conductive shields having different physical parameter values |
US8825179B2 (en) | 2012-04-20 | 2014-09-02 | Cardiac Pacemakers, Inc. | Implantable medical device lead including a unifilar coiled cable |
US8954168B2 (en) | 2012-06-01 | 2015-02-10 | Cardiac Pacemakers, Inc. | Implantable device lead including a distal electrode assembly with a coiled component |
US8958889B2 (en) | 2012-08-31 | 2015-02-17 | Cardiac Pacemakers, Inc. | MRI compatible lead coil |
US8983623B2 (en) | 2012-10-18 | 2015-03-17 | Cardiac Pacemakers, Inc. | Inductive element for providing MRI compatibility in an implantable medical device lead |
CN104520345B (en) | 2012-11-21 | 2017-10-03 | 马萨诸塞州大学 | The poly- poly- mephenesin Carbamate of ammonia isobutene of high intensity |
US9993638B2 (en) | 2013-12-14 | 2018-06-12 | Medtronic, Inc. | Devices, systems and methods to reduce coupling of a shield and a conductor within an implantable medical lead |
AU2015223154B2 (en) | 2014-02-26 | 2017-04-13 | Cardiac Pacemakers, Inc | Construction of an MRI-safe tachycardia lead |
EP3171931B1 (en) | 2014-07-23 | 2021-11-10 | Medtronic, Inc. | Methods of shielding implantable medical leads and implantable medical lead extensions |
US10155111B2 (en) | 2014-07-24 | 2018-12-18 | Medtronic, Inc. | Methods of shielding implantable medical leads and implantable medical lead extensions |
CN107206228A (en) * | 2015-01-20 | 2017-09-26 | Med-El电气医疗器械有限公司 | With the cochleostapedial reflex recording electrode for sacrificing part |
US10603488B2 (en) | 2017-02-10 | 2020-03-31 | Oscor Inc. | Implantable medical devices having diamagnetic conductors and contacts |
US10526429B2 (en) | 2017-03-07 | 2020-01-07 | Cardiac Pacemakers, Inc. | Hydroboration/oxidation of allyl-terminated polyisobutylene |
CN110997746B (en) | 2017-08-17 | 2021-12-28 | 心脏起搏器股份公司 | Photocrosslinked polymers for enhanced durability |
EP3740253B1 (en) | 2018-01-17 | 2023-08-16 | Cardiac Pacemakers, Inc. | End-capped polyisobutylene polyurethane |
US11065461B2 (en) | 2019-07-08 | 2021-07-20 | Bioness Inc. | Implantable power adapter |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5902330A (en) | 1996-07-19 | 1999-05-11 | Ela Medical S.A. | Lead for an implantable medical device using glue expansion chamber and canals |
US6361780B1 (en) | 1998-11-12 | 2002-03-26 | Cardiac Pacemakers, Inc. | Microporous drug delivery system |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3545439A (en) | 1968-01-04 | 1970-12-08 | Upjohn Co | Medicated devices and methods |
US3572344A (en) | 1968-12-31 | 1971-03-23 | Medtronic Inc | Electrode apparatus with lead construction |
US3857934A (en) | 1971-02-02 | 1974-12-31 | Herculite Protective Fab | Activated polymer materials and process for making same |
US3804098A (en) | 1972-04-17 | 1974-04-16 | Medronic Inc | Body implantable lead |
US3788329A (en) | 1972-04-17 | 1974-01-29 | Medtronic Inc | Body implantable lead |
US4018220A (en) | 1974-07-19 | 1977-04-19 | Lionel C. R. Emmett | Method of insertion for intrauterine device of C or omega form with tubular inserter |
US4156429A (en) | 1977-10-11 | 1979-05-29 | Cardiac Pacemakers, Inc. | Implantable electrode |
US4220153A (en) | 1978-05-08 | 1980-09-02 | Pfizer Inc. | Controlled release delivery system |
US4191741A (en) | 1978-09-22 | 1980-03-04 | Eli Lilly And Company | Removable drug implant |
US4328812A (en) | 1980-03-21 | 1982-05-11 | Medtronic, Inc. | Ring electrode for pacing lead |
CA1174284A (en) | 1980-09-02 | 1984-09-11 | Medtronic, Inc. | Body implantable lead |
US4352360A (en) | 1981-03-30 | 1982-10-05 | Medtronic, Inc. | Semiconductor low-threshhold electrode |
US4961931A (en) | 1982-07-29 | 1990-10-09 | Alza Corporation | Method for the management of hyperplasia |
US4506680A (en) | 1983-03-17 | 1985-03-26 | Medtronic, Inc. | Drug dispensing body implantable lead |
US4601893A (en) | 1984-02-08 | 1986-07-22 | Pfizer Inc. | Laminate device for controlled and prolonged release of substances to an ambient environment and method of use |
US4538623A (en) | 1984-04-09 | 1985-09-03 | Medtronic, Inc. | Thread electrode assembly |
US4581028A (en) | 1984-04-30 | 1986-04-08 | The Trustees Of Columbia University In The City Of New York | Infection-resistant materials and method of making same through use of sulfonamides |
US4592372A (en) | 1984-05-22 | 1986-06-03 | Cordis Corporation | Pacing/sensing electrode sleeve and method of forming same |
EP0180264A1 (en) | 1984-10-12 | 1986-05-07 | Akzo N.V. | Release system for two or more active substances |
US4577642A (en) | 1985-02-27 | 1986-03-25 | Medtronic, Inc. | Drug dispensing body implantable lead employing molecular sieves and methods of fabrication |
US4606118A (en) | 1985-02-27 | 1986-08-19 | Medtronic, Inc. | Method of making a drug dispensing body |
US4844099A (en) | 1986-11-24 | 1989-07-04 | Telectronics, N.V. | Porous pacemaker electrode tip using a porous substrate |
US4784161A (en) | 1986-11-24 | 1988-11-15 | Telectronics, N.V. | Porous pacemaker electrode tip using a porous substrate |
US4876109A (en) | 1987-04-13 | 1989-10-24 | Cardiac Pacemakers, Inc. | Soluble covering for cardiac pacing electrode |
US4819662A (en) | 1987-10-26 | 1989-04-11 | Cardiac Pacemakers, Inc. | Cardiac electrode with drug delivery capabilities |
US4819661A (en) | 1987-10-26 | 1989-04-11 | Cardiac Pacemakers, Inc. | Positive fixation cardiac electrode with drug elution capabilities |
DE3821544C2 (en) | 1988-06-25 | 1994-04-28 | H Prof Dr Med Just | Dilatation catheter |
US5003992A (en) | 1989-08-23 | 1991-04-02 | Holleman Timothy W | Atraumatic screw-in lead |
US5002067A (en) | 1989-08-23 | 1991-03-26 | Medtronic, Inc. | Medical electrical lead employing improved penetrating electrode |
US4953564A (en) | 1989-08-23 | 1990-09-04 | Medtronic, Inc. | Screw-in drug eluting lead |
US4972848A (en) | 1989-08-23 | 1990-11-27 | Medtronic, Inc. | Medical electrical lead with polymeric monolithic controlled release device and method of manufacture |
US5255693A (en) | 1989-11-02 | 1993-10-26 | Possis Medical, Inc. | Cardiac lead |
US5217028A (en) | 1989-11-02 | 1993-06-08 | Possis Medical, Inc. | Bipolar cardiac lead with drug eluting device |
US5674192A (en) | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
US5269770A (en) | 1990-01-10 | 1993-12-14 | Rochester Medical Corporation | Microcidal agent releasing catheter with balloon |
AU652377B2 (en) | 1990-06-15 | 1994-08-25 | Medtronic, Inc. | Miniature steroid eluting pacing lead electrode |
US5282844A (en) * | 1990-06-15 | 1994-02-01 | Medtronic, Inc. | High impedance, low polarization, low threshold miniature steriod eluting pacing lead electrodes |
US5324325A (en) | 1991-06-27 | 1994-06-28 | Siemens Pacesetter, Inc. | Myocardial steroid releasing lead |
US5254121A (en) * | 1992-05-22 | 1993-10-19 | Meditron Devices, Inc. | Method and device for removing concretions within human ducts |
US5447533A (en) * | 1992-09-03 | 1995-09-05 | Pacesetter, Inc. | Implantable stimulation lead having an advanceable therapeutic drug delivery system |
US5634901A (en) | 1992-11-02 | 1997-06-03 | Localmed, Inc. | Method of using a catheter sleeve |
US5354327A (en) | 1993-04-07 | 1994-10-11 | Medtronic, Inc. | Conductor coil with specific ratio of torque to bending stiffness |
US5408744A (en) | 1993-04-30 | 1995-04-25 | Medtronic, Inc. | Substrate for a sintered electrode |
US5489294A (en) | 1994-02-01 | 1996-02-06 | Medtronic, Inc. | Steroid eluting stitch-in chronic cardiac lead |
US5496360A (en) | 1994-04-12 | 1996-03-05 | Ventritex, Inc. | Implantable cardiac electrode with rate controlled drug delivery |
US5522874A (en) | 1994-07-28 | 1996-06-04 | Gates; James T. | Medical lead having segmented electrode |
US5844017A (en) | 1995-03-06 | 1998-12-01 | Ethicon, Inc. | Prepolymers of absorbable polyoxaesters containing amines and/or amido groups |
US5545201A (en) * | 1995-03-29 | 1996-08-13 | Pacesetter, Inc. | Bipolar active fixation lead for sensing and pacing the heart |
US5578068A (en) | 1995-05-08 | 1996-11-26 | Medtronic, Inc. | Medical electrical lead with radially asymmetric tip |
US5776178A (en) | 1996-02-21 | 1998-07-07 | Medtronic, Inc. | Medical electrical lead with surface treatment for enhanced fixation |
US5987746A (en) | 1996-02-21 | 1999-11-23 | Medtronic, Inc. | Method of making medical electrical lead |
US6285910B1 (en) * | 1997-04-21 | 2001-09-04 | Medtronic, Inc. | Medical electrical lead |
US5871529A (en) * | 1997-01-16 | 1999-02-16 | Cardiac Pacemakers, Inc. | Electrode for high impedance heart stimulation |
US6086582A (en) | 1997-03-13 | 2000-07-11 | Altman; Peter A. | Cardiac drug delivery system |
US6134463A (en) | 1997-03-31 | 2000-10-17 | Cordis Webster, Inc. | Electrophysiology catheter with a bullseye electrode |
TW358031B (en) | 1997-04-11 | 1999-05-11 | Akze Nobel N V | Drug delivery system for 2 or more active substances |
US5893884A (en) | 1997-05-19 | 1999-04-13 | Irvine Biomedical, Inc. | Catheter system having rollable electrode means |
US5782900A (en) * | 1997-06-23 | 1998-07-21 | Irvine Biomedical, Inc. | Catheter system having safety means |
US5991667A (en) | 1997-11-10 | 1999-11-23 | Vitatron Medical, B.V. | Pacing lead with porous electrode for stable low threshold high impedance pacing |
FR2777465B1 (en) | 1998-04-15 | 2000-06-09 | Ela Medical Sa | INCREASED IMPEDANCE PROBE FOR IMPLANTED MEDICAL DEVICE, PARTICULARLY FOR HEART STIMULATOR |
US6102887A (en) | 1998-08-11 | 2000-08-15 | Biocardia, Inc. | Catheter drug delivery system and method for use |
US6038482A (en) | 1998-10-30 | 2000-03-14 | Pacesetter, Inc. | Open bore electrode with a tiered drug therapy delivery system |
US6141593A (en) | 1998-11-10 | 2000-10-31 | Intermedics Inc. | Cardiac lead with ETEE coated DBS coil |
US6278897B1 (en) * | 1998-12-03 | 2001-08-21 | Medtronic, Inc | Medical electrical lead and introducer system |
US6249709B1 (en) * | 1999-02-18 | 2001-06-19 | Intermedics Inc. | Endocardial defibrillation lead with multi-lumen body and axially mounted distal electrode |
US6298272B1 (en) | 1999-03-29 | 2001-10-02 | Cardiac Pacemakers, Inc. | High impedance electrode tip with internal drug delivery capability |
US6198973B1 (en) | 1999-05-26 | 2001-03-06 | Pacesetter, Inc. | Integrated steroid eluting pacing tip electrode |
US6405091B1 (en) * | 1999-07-20 | 2002-06-11 | Pacesetter, Inc. | Lead assembly with masked microdisk tip electrode and monolithic controlled release device |
US6363286B1 (en) | 1999-09-24 | 2002-03-26 | Cardiac Pacemakers, Inc. | High impedance electrode assembly |
-
2002
- 2002-10-28 US US10/281,744 patent/US6671562B2/en not_active Expired - Lifetime
- 2002-10-28 US US10/282,203 patent/US7187980B2/en not_active Expired - Lifetime
- 2002-11-01 WO PCT/US2002/034975 patent/WO2003041793A2/en not_active Application Discontinuation
- 2002-11-01 EP EP02789350A patent/EP1441806A2/en not_active Withdrawn
- 2002-11-01 EP EP02789349A patent/EP1441805A2/en not_active Withdrawn
- 2002-11-01 WO PCT/US2002/034974 patent/WO2003041792A2/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5902330A (en) | 1996-07-19 | 1999-05-11 | Ela Medical S.A. | Lead for an implantable medical device using glue expansion chamber and canals |
US6361780B1 (en) | 1998-11-12 | 2002-03-26 | Cardiac Pacemakers, Inc. | Microporous drug delivery system |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10029092B2 (en) | 2004-10-20 | 2018-07-24 | Boston Scientific Scimed, Inc. | Leadless cardiac stimulation systems |
US10850092B2 (en) | 2004-10-20 | 2020-12-01 | Boston Scientific Scimed, Inc. | Leadless cardiac stimulation systems |
US10076658B2 (en) | 2004-10-20 | 2018-09-18 | Cardiac Pacemakers, Inc. | Leadless cardiac stimulation systems |
US9545513B2 (en) | 2004-10-20 | 2017-01-17 | Cardiac Pacemakers, Inc. | Leadless cardiac stimulation systems |
US10022538B2 (en) | 2005-12-09 | 2018-07-17 | Boston Scientific Scimed, Inc. | Cardiac stimulation system |
US11154247B2 (en) | 2005-12-09 | 2021-10-26 | Boston Scientific Scimed, Inc. | Cardiac stimulation system |
US11766219B2 (en) | 2005-12-09 | 2023-09-26 | Boston Scientific Scimed, Inc. | Cardiac stimulation system |
WO2007115044A2 (en) * | 2006-03-31 | 2007-10-11 | Boston Scientific Scimed, Inc. | Cardiac stimulation electrodes, delivery devices, and implantation configuration |
WO2007115044A3 (en) * | 2006-03-31 | 2008-02-07 | Boston Scient Scimed Inc | Cardiac stimulation electrodes, delivery devices, and implantation configuration |
US9662487B2 (en) | 2006-07-21 | 2017-05-30 | Boston Scientific Scimed, Inc. | Delivery of cardiac stimulation devices |
US9308374B2 (en) | 2006-07-21 | 2016-04-12 | Boston Scientific Scimed, Inc. | Delivery of cardiac stimulation devices |
US10426952B2 (en) | 2006-07-21 | 2019-10-01 | Boston Scientific Scimed, Inc. | Delivery of cardiac stimulation devices |
US11338130B2 (en) | 2006-07-21 | 2022-05-24 | Boston Scientific Scimed, Inc. | Delivery of cardiac stimulation devices |
US9956401B2 (en) | 2006-09-13 | 2018-05-01 | Boston Scientific Scimed, Inc. | Cardiac stimulation using intravascularly-deliverable electrode assemblies |
Also Published As
Publication number | Publication date |
---|---|
US20030093138A1 (en) | 2003-05-15 |
WO2003041793A3 (en) | 2003-10-30 |
US7187980B2 (en) | 2007-03-06 |
WO2003041792A2 (en) | 2003-05-22 |
EP1441805A2 (en) | 2004-08-04 |
US20030093136A1 (en) | 2003-05-15 |
US6671562B2 (en) | 2003-12-30 |
EP1441806A2 (en) | 2004-08-04 |
WO2003041792A3 (en) | 2003-10-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7187980B2 (en) | Cardiac lead with steroid eluting ring | |
EP1328313B1 (en) | Radiopaque marking of lead electrode zone in a continuous conductor construction | |
US8630719B2 (en) | Implantable medical lead with biased electrode | |
US8332051B2 (en) | High impedance active fixation electrode of an electrical medical lead | |
US6363286B1 (en) | High impedance electrode assembly | |
US8219213B2 (en) | Active fixation cardiac vein medical lead | |
US5800496A (en) | Medical electrical lead having a crush resistant lead body | |
US20090088827A1 (en) | Lead assembly providing sensing or stimulation of spaced-apart myocardial contact areas | |
US20090054941A1 (en) | Stimulation field management | |
EP1481706A1 (en) | Fixation of a left heart medical lead in the coronary sinus | |
US20040133259A1 (en) | High impedance electrode tip | |
US20020042643A1 (en) | Ring electrode with porous member | |
US20120004714A1 (en) | Lead having coil electrode with preferential bending region | |
US6363287B1 (en) | Steroid elution electrodes LVCV, left atrial medical/elecrical leads | |
EP1037690A2 (en) | Lead system | |
US9480834B2 (en) | Multipolar conductor for an implantable medical device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2002789350 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2002789350 Country of ref document: EP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 2002789350 Country of ref document: EP |