WO2003043585A3 - Improved particulate compositions for pulmonary delivery - Google Patents

Improved particulate compositions for pulmonary delivery Download PDF

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Publication number
WO2003043585A3
WO2003043585A3 PCT/US2002/037333 US0237333W WO03043585A3 WO 2003043585 A3 WO2003043585 A3 WO 2003043585A3 US 0237333 W US0237333 W US 0237333W WO 03043585 A3 WO03043585 A3 WO 03043585A3
Authority
WO
WIPO (PCT)
Prior art keywords
particles
drug
improved particulate
pulmonary delivery
particulate compositions
Prior art date
Application number
PCT/US2002/037333
Other languages
French (fr)
Other versions
WO2003043585A2 (en
Inventor
Richard P Batycky
David A Edwards
Original Assignee
Advanced Inhalation Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Inhalation Res Inc filed Critical Advanced Inhalation Res Inc
Priority to CA002465675A priority Critical patent/CA2465675C/en
Priority to AU2002352836A priority patent/AU2002352836B2/en
Priority to EP02789792.5A priority patent/EP1455755B1/en
Priority to JP2003545266A priority patent/JP4368198B2/en
Priority to DK02789792.5T priority patent/DK1455755T3/en
Priority to ES02789792T priority patent/ES2415654T3/en
Publication of WO2003043585A2 publication Critical patent/WO2003043585A2/en
Publication of WO2003043585A3 publication Critical patent/WO2003043585A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Abstract

This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant invention are made by creating hollow, spherical drug particles (i.e., progenitor particles) that collapse in the process of particle formation, leading to wrinkled, thin-walled drug particles of very low envelope density. Additionally, applicants have found that such particles are especially optimal for inhaled aerosols when the surface area parameter (Σ) is greater than 2, optimally greater than 3.
PCT/US2002/037333 2001-11-20 2002-11-20 Improved particulate compositions for pulmonary delivery WO2003043585A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002465675A CA2465675C (en) 2001-11-20 2002-11-20 Improved particulate compositions for pulmonary delivery
AU2002352836A AU2002352836B2 (en) 2001-11-20 2002-11-20 Improved particulate compositions for pulmonary delivery
EP02789792.5A EP1455755B1 (en) 2001-11-20 2002-11-20 Improved particulate compositions for pulmonary delivery
JP2003545266A JP4368198B2 (en) 2001-11-20 2002-11-20 Improved particulate composition for pulmonary delivery
DK02789792.5T DK1455755T3 (en) 2001-11-20 2002-11-20 Improved particle composition for delivery in lung
ES02789792T ES2415654T3 (en) 2001-11-20 2002-11-20 Enhanced particulate compositions for pulmonary delivery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33170801P 2001-11-20 2001-11-20
US60/331,708 2001-11-20

Publications (2)

Publication Number Publication Date
WO2003043585A2 WO2003043585A2 (en) 2003-05-30
WO2003043585A3 true WO2003043585A3 (en) 2003-11-13

Family

ID=23295029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/037333 WO2003043585A2 (en) 2001-11-20 2002-11-20 Improved particulate compositions for pulmonary delivery

Country Status (9)

Country Link
US (2) US7182961B2 (en)
EP (1) EP1455755B1 (en)
JP (1) JP4368198B2 (en)
AU (1) AU2002352836B2 (en)
CA (1) CA2465675C (en)
DK (1) DK1455755T3 (en)
ES (1) ES2415654T3 (en)
PT (1) PT1455755E (en)
WO (1) WO2003043585A2 (en)

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Also Published As

Publication number Publication date
JP4368198B2 (en) 2009-11-18
EP1455755B1 (en) 2013-04-17
US7182961B2 (en) 2007-02-27
US20070104657A1 (en) 2007-05-10
DK1455755T3 (en) 2013-07-15
US20030129139A1 (en) 2003-07-10
JP2005511628A (en) 2005-04-28
EP1455755A4 (en) 2007-05-09
ES2415654T3 (en) 2013-07-26
EP1455755A2 (en) 2004-09-15
AU2002352836A1 (en) 2003-06-10
US7384649B2 (en) 2008-06-10
PT1455755E (en) 2013-06-18
AU2002352836B2 (en) 2005-09-29
WO2003043585A2 (en) 2003-05-30
CA2465675A1 (en) 2003-05-30
CA2465675C (en) 2008-06-10

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