WO2003045352A3 - Osmotic delivery device having a two-way valve and dynamically self-adjusting flow channel - Google Patents

Osmotic delivery device having a two-way valve and dynamically self-adjusting flow channel Download PDF

Info

Publication number
WO2003045352A3
WO2003045352A3 PCT/US2002/037465 US0237465W WO03045352A3 WO 2003045352 A3 WO2003045352 A3 WO 2003045352A3 US 0237465 W US0237465 W US 0237465W WO 03045352 A3 WO03045352 A3 WO 03045352A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
way valve
flow channel
beneficial agent
valve
Prior art date
Application number
PCT/US2002/037465
Other languages
French (fr)
Other versions
WO2003045352A2 (en
Inventor
Jay Gilbert Scott
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Priority to AU2002346482A priority Critical patent/AU2002346482B2/en
Priority to IL16209902A priority patent/IL162099A0/en
Priority to CA002466816A priority patent/CA2466816A1/en
Priority to JP2003546855A priority patent/JP2005515805A/en
Priority to KR10-2004-7007834A priority patent/KR20040055813A/en
Priority to BR0214354-2A priority patent/BR0214354A/en
Priority to NZ533642A priority patent/NZ533642A/en
Priority to MXPA04004881A priority patent/MXPA04004881A/en
Publication of WO2003045352A2 publication Critical patent/WO2003045352A2/en
Publication of WO2003045352A3 publication Critical patent/WO2003045352A3/en
Priority to NO20042404A priority patent/NO20042404L/en

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K17/00—Safety valves; Equalising valves, e.g. pressure relief valves
    • F16K17/20—Excess-flow valves
    • F16K17/22—Excess-flow valves actuated by the difference of pressure between two places in the flow line
    • F16K17/24—Excess-flow valves actuated by the difference of pressure between two places in the flow line acting directly on the cutting-off member
    • F16K17/28—Excess-flow valves actuated by the difference of pressure between two places in the flow line acting directly on the cutting-off member operating in one direction only
    • F16K17/30—Excess-flow valves actuated by the difference of pressure between two places in the flow line acting directly on the cutting-off member operating in one direction only spring-loaded
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/26—Valves closing automatically on disconnecting the line and opening on reconnection thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D7/00—Control of flow
    • G05D7/01—Control of flow without auxiliary power
    • G05D7/0126—Control of flow without auxiliary power the sensing element being a piston or plunger associated with one or more springs
    • G05D7/0133—Control of flow without auxiliary power the sensing element being a piston or plunger associated with one or more springs within the flow-path

Abstract

An implantable, osmotically-driven delivery system having a dynamic, two-way valve (10) and self-adjusting, variable geometry fluid (1) flow channel. As pressure within the agent delivery system goes up, the fluid channel narrows, thereby restricting flow. At exceptionally high pressures, the valve can be designed to close altogether at the orifice or delivery end, or it can provide a minimal leak path so that a maximum fluid flow is never exceeded. At zero or very low pressures, the valve will close completely at the beneficial agent reservoir end, isolating the beneficial agent formulation from external fluid infiltration and thereby eliminating diffusion of external fluid into the beneficial agent formulation.
PCT/US2002/037465 2001-11-21 2002-11-21 Osmotic delivery device having a two-way valve and dynamically self-adjusting flow channel WO2003045352A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2002346482A AU2002346482B2 (en) 2001-11-21 2002-11-21 Osmotic delivery device having a two-way valve and dynamically self-adjusting flow channel
IL16209902A IL162099A0 (en) 2001-11-21 2002-11-21 Osmotic delivery device having a two-way valve anddynamically self-adjusting flow channel
CA002466816A CA2466816A1 (en) 2001-11-21 2002-11-21 Osmotic delivery device having a two-way valve and dynamically self-adjusting flow channel
JP2003546855A JP2005515805A (en) 2001-11-21 2002-11-21 Osmotic delivery device with two-way valve and dynamic self-regulating flow channel
KR10-2004-7007834A KR20040055813A (en) 2001-11-21 2002-11-21 Osmotic delivery device having a two-way valve and dynamically self-adjusting flow channel
BR0214354-2A BR0214354A (en) 2001-11-21 2002-11-21 Osmotic release device having a two-way valve and a dynamically self-adjusting flow channel
NZ533642A NZ533642A (en) 2001-11-21 2002-11-21 Osmotic delivery device having a two-way valve and dynamically self-adjusting flow channel
MXPA04004881A MXPA04004881A (en) 2001-11-21 2002-11-21 Osmotic delivery device having a two-way valve and dynamically self-adjusting flow channel.
NO20042404A NO20042404L (en) 2001-11-21 2004-06-09 Osmotic delivery device with a two-way valve and dynamic self-adjusting flow channel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33210801P 2001-11-21 2001-11-21
US60/332,108 2001-11-21

Publications (2)

Publication Number Publication Date
WO2003045352A2 WO2003045352A2 (en) 2003-06-05
WO2003045352A3 true WO2003045352A3 (en) 2003-10-16

Family

ID=23296751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/037465 WO2003045352A2 (en) 2001-11-21 2002-11-21 Osmotic delivery device having a two-way valve and dynamically self-adjusting flow channel

Country Status (12)

Country Link
JP (1) JP2005515805A (en)
KR (1) KR20040055813A (en)
CN (2) CN1981888A (en)
AU (1) AU2002346482B2 (en)
BR (1) BR0214354A (en)
CA (1) CA2466816A1 (en)
IL (1) IL162099A0 (en)
MX (1) MXPA04004881A (en)
NO (1) NO20042404L (en)
NZ (1) NZ533642A (en)
WO (1) WO2003045352A2 (en)
ZA (1) ZA200404893B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104001261A (en) * 2013-02-27 2014-08-27 重庆市北碚区精神卫生中心 Subcutaneous drug administration device

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7678103B2 (en) 2003-06-12 2010-03-16 Cordis Corporation Orifice device for delivering drugs at low fluid flow rates
US8109922B2 (en) * 2003-06-12 2012-02-07 Cordis Corporation Orifice device having multiple channels and multiple layers for drug delivery
US7211076B2 (en) * 2003-06-12 2007-05-01 Cordis Corporation Medical device for fluid delivery having low fluid flow rate
US6976983B2 (en) 2003-06-12 2005-12-20 Cordis Corporation Implantable device for delivering drugs using orifice mechanism capable of low fluid flow rates
US8491571B2 (en) 2003-06-12 2013-07-23 Cordis Corporation Orifice device having multiple channels with varying flow rates for drug delivery
US7108762B2 (en) * 2003-06-12 2006-09-19 Cordis Corporation Method for manufacturing an orifice mechanism capable of low fluid flow rates
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
DE102005005433B4 (en) * 2005-02-05 2006-10-19 RST Gesellschaft für Wasserspartechnik mbH flow regulator
ITMI20062042A1 (en) * 2006-10-24 2008-04-25 Ceme Spa ELETTROVALVOLA
RU2440097C2 (en) 2007-04-23 2012-01-20 Интарсия Терапьютикс, Инк. Method of treating insulin-independent diabetes and obesity, osmotic delivery system and method for making it
CN102537447B (en) * 2012-02-16 2013-04-24 辽宁卓异装备制造有限公司 Special automatic pressure release valve of rescue capsule
WO2023181996A1 (en) * 2022-03-25 2023-09-28 テルモ株式会社 Administration device

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR640907A (en) * 1927-06-25 1928-07-24 Automatic flow limiter
US3122162A (en) * 1963-06-20 1964-02-25 Asa D Sands Flow control device
US5308348A (en) * 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
US5514110A (en) * 1993-03-22 1996-05-07 Teh; Eutiquio L. Automatic flow control device
EP0812596A1 (en) * 1996-06-14 1997-12-17 Filtertek, S.A. Gravity infusion device for medical infusions
US6183461B1 (en) * 1998-03-11 2001-02-06 Situs Corporation Method for delivering a medication

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR640907A (en) * 1927-06-25 1928-07-24 Automatic flow limiter
US3122162A (en) * 1963-06-20 1964-02-25 Asa D Sands Flow control device
US5308348A (en) * 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
US5514110A (en) * 1993-03-22 1996-05-07 Teh; Eutiquio L. Automatic flow control device
EP0812596A1 (en) * 1996-06-14 1997-12-17 Filtertek, S.A. Gravity infusion device for medical infusions
US6183461B1 (en) * 1998-03-11 2001-02-06 Situs Corporation Method for delivering a medication

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104001261A (en) * 2013-02-27 2014-08-27 重庆市北碚区精神卫生中心 Subcutaneous drug administration device

Also Published As

Publication number Publication date
NZ533642A (en) 2006-12-22
JP2005515805A (en) 2005-06-02
KR20040055813A (en) 2004-06-29
AU2002346482A1 (en) 2003-06-10
ZA200404893B (en) 2005-07-21
CN100352424C (en) 2007-12-05
MXPA04004881A (en) 2004-09-03
BR0214354A (en) 2004-11-03
IL162099A0 (en) 2005-11-20
CN1981888A (en) 2007-06-20
NO20042404L (en) 2004-06-09
AU2002346482B2 (en) 2008-05-01
WO2003045352A2 (en) 2003-06-05
CA2466816A1 (en) 2003-06-05
CN1607939A (en) 2005-04-20

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