WO2003046514A3 - Particle-based ligand assay with extended dynamic range - Google Patents

Particle-based ligand assay with extended dynamic range Download PDF

Info

Publication number
WO2003046514A3
WO2003046514A3 PCT/US2002/038257 US0238257W WO03046514A3 WO 2003046514 A3 WO2003046514 A3 WO 2003046514A3 US 0238257 W US0238257 W US 0238257W WO 03046514 A3 WO03046514 A3 WO 03046514A3
Authority
WO
WIPO (PCT)
Prior art keywords
particle
dynamic range
classes
analyte
based ligand
Prior art date
Application number
PCT/US2002/038257
Other languages
French (fr)
Other versions
WO2003046514A2 (en
Inventor
Michael L Bell
Original Assignee
Beckman Coulter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Priority to EP02784664A priority Critical patent/EP1448990B1/en
Priority to JP2003547906A priority patent/JP4274944B2/en
Priority to DE60236197T priority patent/DE60236197D1/en
Publication of WO2003046514A2 publication Critical patent/WO2003046514A2/en
Publication of WO2003046514A3 publication Critical patent/WO2003046514A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Abstract

This invention relates to methods of assaying one or more analytes simultaneously. The assay of this invention are capable of providing wide dynamic range and rapid processing times. A wide dynamic working range is achieved by simultaneously incubating a sample which may contain the analyte(s) of interest with two or more independently determinable classes of particles coated with an analyte-specific binding partner. The two or more particle classes differ from each other at least in size. The analyte concentration is obtained from readings derived from these two classes by means of a combined standard curve.
PCT/US2002/038257 2001-11-28 2002-11-27 Particle-based ligand assay with extended dynamic range WO2003046514A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02784664A EP1448990B1 (en) 2001-11-28 2002-11-27 Particle-based ligand assay with extended dynamic range
JP2003547906A JP4274944B2 (en) 2001-11-28 2002-11-27 Particle-based ligand assay with extended dynamic range
DE60236197T DE60236197D1 (en) 2001-11-28 2002-11-27 LIGANDEN ASSAY ON PARTICULAR BASE WITH EXTENDED DYNAMIC AREA

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/995,520 US6551788B1 (en) 2001-11-28 2001-11-28 Particle-based ligand assay with extended dynamic range
US09/995,520 2001-11-28

Publications (2)

Publication Number Publication Date
WO2003046514A2 WO2003046514A2 (en) 2003-06-05
WO2003046514A3 true WO2003046514A3 (en) 2003-07-31

Family

ID=25541918

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/038257 WO2003046514A2 (en) 2001-11-28 2002-11-27 Particle-based ligand assay with extended dynamic range

Country Status (5)

Country Link
US (1) US6551788B1 (en)
EP (1) EP1448990B1 (en)
JP (1) JP4274944B2 (en)
DE (1) DE60236197D1 (en)
WO (1) WO2003046514A2 (en)

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* Cited by examiner, † Cited by third party
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DE10156612A1 (en) * 2001-11-20 2003-05-28 Markus Klotz To determine the presence of a substance, in a liquid or gas sample, a possible micro-particle size category is taken to be bonded with the sample substance by hybridizing for measurement by particle size/fluorescent light signals
EP1616179A4 (en) * 2001-12-21 2006-07-12 Centocor Inc A novel screening method for molecular antagonist using flow-cytometry
EP1756548B1 (en) * 2004-05-26 2015-06-24 Genera Biosystems Limited Biosensor using whispering gallery modes in microspheres
EP1825267A4 (en) * 2004-11-29 2008-07-09 Perkinelmer Life & Analytical Sciences Prticle-based multiplex assay for identifying glycosylation
US7396689B2 (en) * 2005-02-04 2008-07-08 Decision Biomarkers Incorporated Method of adjusting the working range of a multi-analyte assay
US7723127B2 (en) * 2005-03-03 2010-05-25 Novx Systems Inc. Immunoassay with extended dynamic range
JP4902183B2 (en) * 2005-12-06 2012-03-21 日立マクセル株式会社 Functional infrared fluorescent particles
EP2048502A4 (en) * 2006-07-13 2009-08-19 Olympus Corp Method of confirming the specimen-detecting activity of microparticles
JP5855332B2 (en) 2006-10-18 2016-02-09 アクセラ インコーポレーテッド Measurement of multiple analytes over a wide concentration range by light diffraction.
WO2008070570A2 (en) * 2006-12-01 2008-06-12 Cedars-Sinai Medical Center Positive selection of serum proteins for proteomic analysis
JP4980944B2 (en) * 2008-02-12 2012-07-18 富士フイルム株式会社 Immunological measurement method
US8338189B2 (en) 2008-03-05 2012-12-25 Axela Inc. Detection of biomarkers and biomarker complexes
KR20120016286A (en) * 2009-05-22 2012-02-23 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Multilayer colorimetric sensor arrays
EP2513650A4 (en) 2009-12-17 2013-12-18 Abay Sa Novel assays for detecting analytes in samples and kits and compositions related thereto
US8648016B2 (en) * 2010-02-08 2014-02-11 Robert Bosch Gmbh Array with extended dynamic range and associated method
WO2012049316A1 (en) 2010-10-15 2012-04-19 Olink Ab Dynamic range methods
CA2804843C (en) * 2012-02-06 2021-02-02 Ortho-Clinical Diagnostics, Inc. Multiple time windows for extending the range of an assay
AU2015236288A1 (en) * 2014-03-26 2016-09-15 Siemens Healthcare Diagnostics Inc. Luminescent oxygen channeling immunoassay utilizing three antibodies and methods of production and use thereof
TWI614502B (en) * 2017-07-26 2018-02-11 國立成功大學 Detection method for detecting analyte concentration
US11391735B2 (en) 2017-09-06 2022-07-19 AimPlex Biosciences, Inc. Methods for improving the dynamic range of biological assays

Citations (4)

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Publication number Priority date Publication date Assignee Title
WO1989011101A1 (en) * 1988-05-11 1989-11-16 Dynal A.S. Method of assay
US5851777A (en) * 1996-02-05 1998-12-22 Dade Behring Inc. Homogeneous sol-sol assay
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US6248597B1 (en) * 1997-08-11 2001-06-19 Roche Diagnostics Corporation Microparticle enhanced light scattering agglutination assay

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GB8911101D0 (en) 1989-05-15 1989-06-28 Courtaulds Plc Production of cut pile fabric on a knitting machine
ATE171543T1 (en) 1991-07-16 1998-10-15 Transmed Biotech Inc METHODS AND COMPOSITIONS FOR THE SIMULTANEOUS ANALYSIS OF A MULTIPLE ANALYTES
US5314804A (en) * 1992-03-24 1994-05-24 Serim Research Corporation Test for Helicobacter pylori
US6200820B1 (en) 1992-12-22 2001-03-13 Sienna Biotech, Inc. Light scatter-based immunoassay
GB9326379D0 (en) 1993-12-23 1994-02-23 Sinvent As Method of assay
GB9326238D0 (en) * 1993-12-23 1994-02-23 Sinvent As Method of assay
US6165739A (en) * 1996-03-13 2000-12-26 Compucyte Corporation Multiple simultaneous testing media
US6327410B1 (en) * 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989011101A1 (en) * 1988-05-11 1989-11-16 Dynal A.S. Method of assay
US5585241A (en) * 1988-05-11 1996-12-17 Sinvent A/S Method of assay
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US5851777A (en) * 1996-02-05 1998-12-22 Dade Behring Inc. Homogeneous sol-sol assay
US6248597B1 (en) * 1997-08-11 2001-06-19 Roche Diagnostics Corporation Microparticle enhanced light scattering agglutination assay

Also Published As

Publication number Publication date
EP1448990A4 (en) 2005-05-18
EP1448990A2 (en) 2004-08-25
DE60236197D1 (en) 2010-06-10
JP2005510706A (en) 2005-04-21
EP1448990B1 (en) 2010-04-28
JP4274944B2 (en) 2009-06-10
US6551788B1 (en) 2003-04-22
WO2003046514A2 (en) 2003-06-05

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