WO2003047501A3 - Novel anti-cancer therapeutic compounds - Google Patents

Novel anti-cancer therapeutic compounds Download PDF

Info

Publication number
WO2003047501A3
WO2003047501A3 PCT/IL2002/000982 IL0200982W WO03047501A3 WO 2003047501 A3 WO2003047501 A3 WO 2003047501A3 IL 0200982 W IL0200982 W IL 0200982W WO 03047501 A3 WO03047501 A3 WO 03047501A3
Authority
WO
WIPO (PCT)
Prior art keywords
daltons
activity
oligosaccharide
therapeutic compounds
sugar units
Prior art date
Application number
PCT/IL2002/000982
Other languages
French (fr)
Other versions
WO2003047501A2 (en
Inventor
Liora Cahalon
Irun R Cohen
Ofer Lider
Raanan Margalit
Original Assignee
Yeda Res & Dev
Liora Cahalon
Irun R Cohen
Ofer Lider
Raanan Margalit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Liora Cahalon, Irun R Cohen, Ofer Lider, Raanan Margalit filed Critical Yeda Res & Dev
Priority to AU2002358944A priority Critical patent/AU2002358944A1/en
Publication of WO2003047501A2 publication Critical patent/WO2003047501A2/en
Publication of WO2003047501A3 publication Critical patent/WO2003047501A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate

Abstract

A treatment for cancer, and in particular, of therapeutic compounds which block the ability of cytokines and chemokines to promote metastasis of malignant cells. The therapeutic compound comprises a carboxylated and/or sulfated oligosaccharide, preferably in a substantially purified form, which is a heparin or heparan-sulfate derived saccharide compound. In one embodiment of the present invention, the carbohydrate or oligosaccharide has a molecular weight of no more than about 3000 daltons, preferably lying in the range of about 400 to about 2000 daltons, most preferably between about 400 and about 1100 daltons. Generally, substances of the present invention inhibit tumor cell migration, as determined by biological assays, and comprise molecules of various sugar units of which the basic unit of activity is associated with a disaccharide. However, larger oligosaccharide chains of up to about 10 sugar units, containing the basic disaccharide unit of activity can also function to inhibit such activity.
PCT/IL2002/000982 2001-12-05 2002-12-05 Novel anti-cancer therapeutic compounds WO2003047501A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002358944A AU2002358944A1 (en) 2001-12-05 2002-12-05 Novel anti-cancer therapeutic compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/002,145 US7285536B2 (en) 2001-12-05 2001-12-05 Anti-cancer therapeutic compounds
US10/002,145 2001-12-05

Publications (2)

Publication Number Publication Date
WO2003047501A2 WO2003047501A2 (en) 2003-06-12
WO2003047501A3 true WO2003047501A3 (en) 2004-08-05

Family

ID=21699418

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2002/000982 WO2003047501A2 (en) 2001-12-05 2002-12-05 Novel anti-cancer therapeutic compounds

Country Status (3)

Country Link
US (1) US7285536B2 (en)
AU (1) AU2002358944A1 (en)
WO (1) WO2003047501A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750207B1 (en) * 1992-05-01 2004-06-15 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
US7285536B2 (en) 2001-12-05 2007-10-23 Yeda Research And Development Co., Ltd. Anti-cancer therapeutic compounds
CN1819833A (en) * 2004-03-29 2006-08-16 克霖固鲁制药股份有限公司 Hgf production accelerator containing heparin-like oligosaccharide
JP2010150232A (en) * 2008-11-19 2010-07-08 National Institute Of Advanced Industrial Science & Technology Selective inhibitor of fibroblast growth factor receptor
US9849087B2 (en) 2011-11-08 2017-12-26 The Board Of Trustees Of The University Of Arkansas Methods and compositions for X-ray induced release from pH sensitive liposomes
US20210330693A1 (en) * 2018-12-05 2021-10-28 Wayne State University Heparanase inhibitors and their use as anti-cancer compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882318A (en) * 1986-06-26 1989-11-21 Hadassa Medical Organization Method for decreasing tumor metastasis

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US446314A (en) * 1891-02-10 George p
US1950100A (en) 1932-06-02 1934-03-06 Jr Lathan A Crandall Chondroitin compounds and their preparation
IL61201A (en) 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
US4446314A (en) 1980-09-30 1984-05-01 Cutter Laboratories, Inc. Fractionation of heparin
US4818816A (en) 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
FR2535324A1 (en) 1982-10-27 1984-05-04 Choay Sa PERFECTED STATION FOR THE PURIFICATION OF WASTEWATER
FR2504535B1 (en) 1981-04-28 1987-08-14 Choay Sa DISACCHARIDES DERIVED FROM URONIC ACID AND GLUCOSAMINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE CONTROL OF BLOOD COAGULATION
US4987223A (en) 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
US4801583A (en) 1982-01-15 1989-01-31 Choay S.A. Oligosaccharides and their biological applications
US4539398A (en) 1982-01-22 1985-09-03 Riker Laboratories, Inc. Affinity fractionation of heparin on immobilized Concanavalin A
DK168876B1 (en) 1982-12-20 1994-07-04 Harvard College Agent that can be administered orally or subcutaneously to inhibit mammalian angiogenesis and method of preparing such agent
FR2538404B1 (en) 1982-12-28 1985-08-23 Anic Spa
IT1195497B (en) 1983-03-08 1988-10-19 Opocrin Spa PROCEDURE FOR THE PREPARATION OF OLIGOSACCHARIDIC FRACTIONS EQUIPPED WITH PHARMACOLOGICAL PROPERTIES FOR CHEMICAL DEGRADATION OF HEPARIN
US4468385A (en) 1983-08-29 1984-08-28 American Cyanamid Company Poly-cation salts of 4-O-poly-hexaose-thio-alkylene sulfate derivatives and method of use
IT1214609B (en) 1985-05-17 1990-01-18 Opocrin Spa HEXOSAMINOGLICANS DEPOLYMERIZED SULPHATES FOR ANTI-THROMBOTIC, FIBRINOLITHIC, ANTI-INFLAMMATORY ACTIVITIES, THEIR PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US4900502A (en) * 1985-08-29 1990-02-13 Bend Research, Inc. Hollow fiber annealing
US4889808A (en) 1985-10-01 1989-12-26 American Home Products Method of enchancing t-PA and SCU-PA production
FR2597484B1 (en) 1986-04-17 1988-12-23 Sanofi Sa GLYCOSAMINOGLYCANS OF THE HEPARIN OR HEPARANE-SULPHATE TYPE WITH ACTIVITY ON CELL DIVISION AND DIFFERENTIATION, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS.
IL85145A (en) 1987-01-23 1994-08-26 Univ Australian Anti-metastatic pharmaceutical or veterinary compositions containing modified heparin having reduced anticoagulant activity
FR2614026B1 (en) 1987-04-16 1992-04-17 Sanofi Sa LOW MOLECULAR WEIGHT HEPARINS WITH REGULAR STRUCTURE, THEIR PREPARATION AND THEIR BIOLOGICAL APPLICATIONS
DK505488D0 (en) 1987-12-21 1988-09-09 Bar Shalom Daniel MEDIUM AND USE OF SAME
IT1234508B (en) 1988-06-10 1992-05-19 Alfa Wassermann Spa HEPARIN DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION
US4981955A (en) 1988-06-28 1991-01-01 Lopez Lorenzo L Depolymerization method of heparin
WO1990003791A1 (en) 1988-10-05 1990-04-19 Nicola Diferrante Methods for interfering with hiv multiplication and composition for the treatment of aids
IL88554A0 (en) 1988-12-01 1989-07-31 Hadassah Med Org Compositions containing a compound binding to a heparin receptor
PT93847A (en) 1989-04-24 1990-11-20 Harvard College PROCESS FOR THE PREPARATION OF OLIGOSACARIDES OF LOW MOLECULAR WEIGHT DERIVED FROM HEPARIN OR DESPOLYMENED HEPARAN SULFATE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
JPH06507635A (en) 1991-05-02 1994-09-01 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド Compositions for the prevention and/or treatment of pathological processes
US5580858A (en) 1991-06-10 1996-12-03 Alberta Research Council Immunosuppressive and tolerogenic modified Lewisx compounds
US6750207B1 (en) 1992-05-01 2004-06-15 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
US5861382A (en) 1992-05-01 1999-01-19 Yeda Research And Development Co. Ltd. Methods for regulation of active TNF-α
WO1994011006A1 (en) 1992-11-10 1994-05-26 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
US7285536B2 (en) 2001-12-05 2007-10-23 Yeda Research And Development Co., Ltd. Anti-cancer therapeutic compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882318A (en) * 1986-06-26 1989-11-21 Hadassa Medical Organization Method for decreasing tumor metastasis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VLODAVSKY ET AL: "Modulation of Neovascularization and Metastasis by Species of Heparin", HEPARIN AND RELATED POLYSACCHARIDES - ADV EXP MED BIOL, vol. 313, 1992, pages 317 - 327, XP002978415 *

Also Published As

Publication number Publication date
WO2003047501A2 (en) 2003-06-12
US7285536B2 (en) 2007-10-23
AU2002358944A1 (en) 2003-06-17
US20030130230A1 (en) 2003-07-10
AU2002358944A8 (en) 2003-06-17

Similar Documents

Publication Publication Date Title
Mizumoto et al. Interaction of chondroitin sulfate and dermatan sulfate from various biological sources with heparin-binding growth factors and cytokines
PL346520A1 (en) Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
Toida et al. Structure and bioactivity of sulfated polysaccharides
IE881150L (en) Low molecular weight heparins of regular structure, their¹preparation and their biological uses
BR9910307A (en) Wheat enzymes, which encode nucleic acid molecules, which take part in the synthesis of starch
Desai et al. Mechanism of heparin activation of antithrombin: evidence for an induced-fit model of allosteric activation involving two interaction subsites
Alban et al. Partial synthetic glucan sulfates as potential new antithrombotics: a review
BR0010989A (en) Genetically modified plants and plant cells with increased activity of an amylosaccharide protein and a branching enzyme
WO2006010557A8 (en) D-glucopyranosyl phenyl-substituted cyclene, medicaments containing these compounds, their use, and method for the production thereof
BR9910311A (en) Nucleic acid molecules encoding wheat enzymes, which participate in the synthesis of starch
FR2840612B1 (en) HIGHLY BRANCHED SOLUBLE GLUCOSE POLYMERS AND PROCESS FOR OBTAINING THEM
WO2003028738A3 (en) Anti-infectious carbohydrates
BR0109062A (en) Aryl fructose-1,6-bisphosphatase inhibitors
ATE323501T1 (en) PHARMACEUTICAL COMPOSITION CONTAINING PROTEOGLYCAN AND USE THEREOF FOR THE TREATMENT OF INFLAMMATORY DISEASES
PT1070503E (en) COMPOSITIONS UNDERSTANDING VERY REDUCED MOLECULAR WEIGHT HEPARIN
NO930975D0 (en) MOISTURIZING ONE-COMPONENT POLYSILOX COMPOUND
WO2003047501A3 (en) Novel anti-cancer therapeutic compounds
DK0960132T3 (en) Polysaccharide, microorganism and process for its preparation, preparation thereof and use
WO1998040081A1 (en) Sulfated oligosaccharides having anticoagulant/antithrombotic activity
WO2004028686A3 (en) Liquid absorbing polymer, a process and a vessel for its production
CA2315239A1 (en) Nucleotide and protein sequence of mammastatin and methods of use
CA2296178A1 (en) Human intestinal npt2b
AU2003227731A1 (en) Active carbohydrate containing protecting reagents for chemical modifications, their production and use
Franz et al. Novel pharmaceutical applications of polysaccharides
WO2000047163A3 (en) Use of hyaluronic acid or fragments thereof for regulating hematopoietic differentiation

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP