WO2003049744B1 - Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology - Google Patents

Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology

Info

Publication number
WO2003049744B1
WO2003049744B1 PCT/US2002/038602 US0238602W WO03049744B1 WO 2003049744 B1 WO2003049744 B1 WO 2003049744B1 US 0238602 W US0238602 W US 0238602W WO 03049744 B1 WO03049744 B1 WO 03049744B1
Authority
WO
WIPO (PCT)
Prior art keywords
estrogen
administered
consecutive days
period
combination
Prior art date
Application number
PCT/US2002/038602
Other languages
French (fr)
Other versions
WO2003049744A1 (en
Inventor
Robert G Bell
Carole Ben-Maimon
Beata Iskold
Original Assignee
Barr Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23313290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003049744(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to JP2003550793A priority Critical patent/JP2005516913A/en
Priority to HU0402651A priority patent/HU230759B1/en
Priority to IL16218202A priority patent/IL162182A0/en
Priority to SI200231034T priority patent/SI1453521T1/en
Priority to AU2002348272A priority patent/AU2002348272B2/en
Priority to MXPA04005445A priority patent/MXPA04005445A/en
Priority to CA2468748A priority patent/CA2468748C/en
Priority to EP02782404.4A priority patent/EP1453521B1/en
Priority to BR0214716A priority patent/BRPI0214716B8/en
Application filed by Barr Lab Inc filed Critical Barr Lab Inc
Priority to ES02782404T priority patent/ES2428118T3/en
Priority to DK02782404.4T priority patent/DK1453521T3/en
Priority to NZ533242A priority patent/NZ533242A/en
Publication of WO2003049744A1 publication Critical patent/WO2003049744A1/en
Publication of WO2003049744B1 publication Critical patent/WO2003049744B1/en
Priority to IL162182A priority patent/IL162182A/en
Priority to ZA2004/04249A priority patent/ZA200404249B/en
Priority to HK05108410.0A priority patent/HK1076716A1/en
Priority to IL207561A priority patent/IL207561A0/en
Priority to LU93156C priority patent/LU93156I2/en
Priority to HUS1800033C priority patent/HUS1800033I1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens

Abstract

This invention relates to a method of preventing pregnancy and treating PMS including PMDD. More particularly, the invention relates to a method, which involves administering one of several combination oral contraceptive regimens in combination with an antidepressant and a kit containing the same.

Claims

44
AMENDED CLAIMS
[received by the International Bureau on 04 June 2003 (04.06.03); original claims 1-83 replaced by new claims
1-92 (15 pages)]
1. A method of diminishing a premenstrual symptom in a female in need thereof, said method comprising administering to said female a combination of estrogen and rogestin for a period of 60 to 110 consecutive days, followed by administration of estrogen for a period of 2 to 10 consecutive days.
2. The method of claim 1, wherein the combination of estrogen and progestin is administered for a period of 81 to 89 consecutive days.
3. The method of claim 2, wherein the estrogen that is administered in combination with progestin for a period of 81 to 89 consecutive days is administered in a daily amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol.
4. The method of claim 3, wherein the estrogen that is administered for a period of 2 to 10 consecutive days is administered in a daily amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol.
5. The method of claim 4, wherein the progestin that is administered in combination with estrogen for a period of 81 to 89 consecutive days is administered in a daily amount equivalent to about 0.05 mg to about 1.5 mg of levonorgestrel.
6. The method of claim 5, wherein the combination of estrogen and progestin is administered for at least 84 consecutive days.
7. The method of claim 1 , wherein the estrogen that is administered for a period of 2 to 10 consecutive days is administered for a period of 5 to 8 consecutive days. 45
8. The method of claim 7, wherein the estrogen that is administered for a period of 5 to 8 consecutive days is administered for at least 7 consecutive days.
9. The method of claim 5, in which the estrogen is ethinyl estradiol.
10. The method of claim 9, in which the progestin is levonorgestrel.
11. The method of claim 1 , wherein said premenstrual symptom is selected from the group consisting of irritability, mood swings, depression, hostility, social withdrawal, bloating, breast tenderness, myalgia, migraine, headache, fatigue, anger, and tension.
12. The method of claim 1, wherein said female has Premenstrual Dysphoric Disorder (PMDD).
13. A method of diminishing a premenstrual symptom in a female in need thereof, said method comprising administering to said female a combination of estrogen and progestin for a period of 60 to 110 consecutive days, followed by administration of estrogen for a period of 2 to 10 consecutive days, wherein an antidepressant is administered (i) in combination with the estrogen for the period of 2 to 10 consecutive days, (ii) intermittently, (iii) one time, or (iv) once weekly.
14. The method of claim 13, wherein the combination of estrogen and progestin is administered for a period of 81 to 89 consecutive days.
15- The method of claim 13, wherein the antidepressant that is administered in combination with the estrogen for the period of 2 to 10 consecutive days (i) is administered for a period of 5 to 8 consecutive days. 46
16. The method of claim 15, wherein the estrogen that is administered in combination with progestin for the period of 81 to 89 consecutive days is administered in a daily amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol.
17. The method of claim 15, wherein the estrogen that is administered in combination with the antidepressant for the period of 5 to 8 consecutive days is administered in a daily amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol.
18. The method of claim 17, wherein the progestin that is administered in combination with estrogen for the period of 81 to 89 consecutive days is administered in a daily amount equivalent to about 0.05 mg to about 1.5 mg of levonorgestrel.
19. The method of claim 18, in which the antidepressant administered in combination with the estrogen for the period of 5 to 8 consecutive days is administered in a daily amount equivalent to about 5 mg to about 120 mg of fluoxetme hydrochloride.
20. The method of claim 14, wherein the combination of estrogen and progestin that is administered for the period of 81 to 89 consecutive days is administered for at least 84 consecutive days.
21. The method of claim 15, wherein the combination of estrogen and antidepressant that is administered for the period of 5 to 8 consecutive days is administered for at least 7 consecutive days.
22. The method of claim 19, in which the estrogen is ethinyl estradiol.
23. The method of claim 22, in which the progestin is levonorgestrel.
24. The method of claim 23, in which the antidepressant is fiuoxetine hydrochloride.
25. The method of claim 13, wherein the antidepressant is administered in combination with the estrogen or the combination of estrogen and progestin in a single tablet.
26. The method of claim 13, wherein the antidepressant is administered one time in combination with one dose of the estrogen or one dose of the combination of estrogen and progestin.
27. The method of claim 13, wherein the premenstrual symptom is selected f om the group consisting of irritability, mood swings, depression, hostility, social withdrawal, bloating, breast tenderness, myalgia, migraine, headache, fatigue, anger, and tension.
28. The method of claim 13, wherein said female has Premenstrual Dysphoric Disorder (PMDD).
29. A method of diminishing a premenstrual symptom in a female in need thereof, said method comprising administering to said female a combination of estrogen and progestin for a period of 21 to 26 consecutive days, followed by administration of estrogen for a period of 2 to 10 consecutive days, wherein an antidepressant is administered (i) in combination with the estrogen for the period of 2 to 10 consecutive days, (ϋ) intermittently, (iii) one time, or (iv) once weekly, 48
30. The method of claim 29, wherein the combination of estrogen and progestin that is administered for the period of 21 to 26 consecutive days is administered for a period of 22 to 25 consecutive days.
31. The method of claim 30, wherein the combination of estrogen and an antidepressant that is administered for the period of 2 to 10 consecutive days is administered for a period of 2 to 7 consecutive days,
32. The method of claim 31 , wherein the estrogen that is admimstered in combination with progestin for the period of 22 to 25 consecutive days is administered in a daily amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol.
33. The method ofclaim 32, wherein the estrogen that is administered in combination with the antidepressant for the period of 2 to 7 consecutive days is administered in a daily amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol.
34. The method o claim 33, wherein the progestin that is administered in combination with estrogen for the period of 22 to 25 consecutive days is admimstered in a daily amount equivalent to about 0.05 mg to about 1.5 mg of levonorgestrel.
35. The method of claim 34, wherein the antidepressant that is administered in combination with the estrogen for the period of 2 to 7 consecutive days is administered in a daily amount equivalent to about 5 mg to about 120 mg of fiuoxetine hydrochloride. 49
36. The method ofclaim 31 , wherein the combination of estrogen and progestin that is administered for the period of 22 to 25 consecutive days is administered for 25 consecutive days.
37. The method ofclaim 36, wherein the combination of estrogen and antidepressant that is administered for the period of 2 to 7 consecutive days is administered for 7 consecutive days.
38 , The method of claim 36, wherein the estrogen is ethinyl estradiol.
39. The method of claim 33, wherein the progestin is levonorgestrel.
40. The method ofclaim 37, wherein the estrogen is ethinyl estradiol, the progestin is levonorgestrel, and the antidepressant is fiuoxetine hydrochloride.
41. The method of claim 29, wherein the antidepressant is administered in combination with the estrogen or the combination of estrogen and progestin in a single tablet.
42. The method of claim 41, wherein the antidepressant is administered in combination with one dose of the estrogen or one dose of the combination of estrogen and progestin,
43. The method of claim 29, wherein the premenstrual symptom is selected from the group consisting of irritability, mood swings, depression, hostility, social withdrawal, bloating, breast tenderness, myalgia, migraine, headache, fatigue, anger, and tension. 50
44. The method of claim 29, wherein said female has Premenstrual Dysphoric Disorder (PMDD).
45. A method of diminishing an estrogen withdrawal symptom in a female in need thereof, said method comprising administering to said female a combination of estrogen and progestin for aperiod of 60 to 110 consecutive days, followed by administration of estrogen for a period of 2 to 10 consecutive days.
46. The method of claim 45, wherein the estrogen withdrawal symptom is selected from the group consisting of headache, migraine, breast tenderness, bloating, and abdominal pain.
47. The method ofclaim 45, wherein an antidepressant is administered (i) in combination with the estrogen for the period of 2 to 10 consecutive days, (ii) intermittently, (iii) one time, or (iv) once weekly.
48. The method of claim 45, wherein: the estrogen that is administered in combination with progestin for the period of 60 to 110 consecutive days is administered in a daily amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol; the estrogen that is administered for the period of 2 to 10 consecutive days is administered in a daily amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol; and the progestin that is administered in combination with estrogen for the period of 60 to 110 consecutive days is administered in a daily amount equivalent to about 0,05 mg to about 1 ,5 mg of levonorgestrel.
49. The method of claim 48, wherein: the estrogen that is administered in combination with progestin for the period of 60 to 110 consecutive days is ethinyl estradiol; 51
the estrogen that is administered for the period of 2 to 10 consecutive days is ethinyl estradiol; and the progestin that is administered in combinati on with estrogen for the period of 60 to 110 consecutive days is levonorgestrel.
50. The method ofclaim 47, wherein: the estrogen that is administered in combination with progestin for the period of 60 to 110 consecutive days is administered in a daily amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol; the progestin that is administered in combination with estrogen for the period of 60 to 110 consecutive days is administered in a daily amount equivalent to about 0.05 mg to about 1.5 mg of levonorgestrel; the estrogen that is administered for the period of 2 to 10 consecutive days is administered in a daily amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol; and the antidepressant that is administered in combination with estrogen for the period of 2 to 10 consecutive days is administered in a daily amount equivalent to about 5 g to about 120 mg of fiuoxetine hydrochloride.
51. The method of claim 50, wherein: the estrogen that is administered in combination with progestin for the period of 60 to 110 consecutive days is ethinyl estradiol; the estrogen that is administered for the period of 2 to 10 consecutive days is ethinyl estradiol; the progestin that is administered in combination with estrogen for the period of 60 to 110 consecutive days is levonorgestrel; and the antidepressant that is administered in combination with estrogen for the period of 2 to 10 consecutive days is fiuoxetine hydrochloride. 52
52. A method of diminishing an estrogen withdrawal symptom in a female in need thereof, said method comprising administering to said female a combination of estrogen and progestin for aperiod of 21 to 26 consecutive days, followed by administration of estrogen for aperiod of 2 tolO consecutive days.
53. The method of claim 52, wherein the estrogen withdrawal symptom is selected from the group consisting of headache, migraine, breast tenderness, bloating, and abdominal pain.
54. Themethod ofclaim 52, wherein an antidepressant is administered (i) in combination with the estrogen for the period of 2 to 10 consecutive days, (ii) intermittently, (iii) one time, or (iv) once weekly.
55. A kit comprising: (a) 60-110 tablets comprising estrogen and progestin optionally combined with an antidepressant; and (b) 2-10 tablets comprising estrogen optionally combined with an antidepressant.
56. The kit of claim 55, wherein the tablets comprising estrogen and progestin optionally combined with the antidepressant include 81 to 89 tablets, and wherein the tablets comprising estrogen optionally combined with the antidepressant include 2 to 7 tablets,
57. A kit comprising: (a) 21-26 tablets comprising estrogen and progestin optionally combined with an antidepressant; and (b) 2-10 tablets comprising estrogen optionally combined with an antidepressant.
58. The kit of claim 55, wherein the estrogen in each of the tablets comprising estrogen and progestin optionally combined with the antidepressant is present in an amount equivalent to about 5 μg to about 50 μg of ethinyl estrad ol, and wherein the estrogen in each of the tablets comprising estrogen 53
optionally combined with the antidepressant is present in an amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol.
59. The kit of claim 58, wherein the progestin in each of the tablets comprising estrogen and progestin optionally combined with the antidepressant is present in an amount equivalent to about 0.05 mg to about 1.5 mg of levonorgestrel.
60. The kit ofclaim 55, wherein the tablets comprising estrogen in (b) include the antidepressant in all tablets, some tablets, one tablet or once-weekly tablet.
61. The kit of claim 60, wherein the tablets comprising estrogen and progestin include about 84 tablets, and wherein the tablets comprising estrogen and the antidepressant include about 7 tablets,
62. The kit ofclaim 57, wherein the tablets comprising estrogen and progestin optionally combined with the antidepressant include 22 to 25 tablets, and wherein the tablets comprising estrogen optionally combined ith the antidepressant include 2 to 7 tablets,
63. The kit of claim 60, wherein; the estrogen in each of the tablets comprising estrogen and progestin is present in an amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol; the estrogen in each of the tablets comprising estrogen combined with the antidepressant, is present in an amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol; the progestin in each of the tablets comprising estrogen and progestin is present in an amount equivalent to about 0.05 mg to about 1.5 mg of 54
levonorgestrel; and the antidepressant in each of the tablets comprising estrogen and antidepressant is present in an amount equivalent to about 5 mg to about 120 mg of fiuoxetine hydrochloride.
64. A preparation comprising about 60 to about 110 dosage forms comprising a combination of estrogen and progestin, and about 2 to about 10 dosage forms comprising estrogen.
65. The preparation ofclaim 64, wherein the about 60 to about 110 dosage forms or the about 2 to about 10 dosage forms are combined with an antidepressant for all dosage forms, some dosage forms, one dosage form, or once-weekly dosage form.
66. A preparation comprising about 21 to about 26 dosage forms comprising a combination of estrogen and progestin and about 2 to about 10 dosage forms comprising estrogen.
67. The preparation of claim 66, wherein the about 2 to about 10 dosage forms comprise estrogen combined with an antidepressant for all dosage forms, some dosage forms, one dosage form, or once-weekly dosage form.
68. A method of contraception in a female in need thereof, said method comprising administering to said female a combination of estrogen and progestin for a period of 60 to 110 consecutive days, followed by administration of estrogen for a period of 2 to 10 consecutive days.
69. The method ofclaim 68, wherein the combination of estrogen and progestin that is administered for the period of 60 to 110 consecutive days is administered for a period of 81 to 89 consecutive days. 55
70. The method ofclaim 69, wherein the estrogen that is administered for the period of 81 to 89 consecutive days is administered in a daily amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol,
71. The method of claim 69, wherein the estrogen that is administered for the period of 2 to 10 consecutive days is administered in a daily amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol.
72. The method ofclaim 70, wherein the progestin that is administered in combination with estrogen for the period of 81 to 89 consecutive days is administered in a daily amount equivalent to about 0.05 mg to about 1.5 mg of levonorgestrel.
73. A method of contraception in a female in need thereof, said method comprising administering to said female a combination of estrogen and progestin for period of 60 to 110 consecutive days, followed by administration of estrogen for aperiod of 2 to 10 consecutive days, wherein an antidepressant is administered (i) in combination with the estrogen for the period of 2 to 10 consecutive days, (ii) intermittently, (iii) one time, or (iv) once weekly.
74. The method ofclaim 73 , wherein the combination of estrogen and progestin that is administered for the period of 60 to 110 consecutive days is administered for a period of 81 to 89 consecutive days.
75. The method ofclaim 73, wherein the combination of estrogen and antidepressant that is administered for the period of 2 to 10 consecutive days is administered for a period of 5 to 8 consecutive days.
76. The method ofclaim 74, wherein the estrogen that is administered in combination with progestin for the period of 81 to 89 consecutive days is 56
administered in a daily amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol,
77. The method ofclaim 74, wherein the estrogen that is administered in combination with antidepressant for the period of 5 to 8 consecutive days is administered in a daily amount equivalent to about 5 μgto about 50 μg of ethinyl estradiol.
78. Themethodofclai 77,whereintheρrogestinthatis administered in combination with estrogen for the period of 81 to 89 consecutive days is administered in a daily amount equivalent to about 0.05 mg to about 1.5 mg of levonorgestrel.
79. The method ofclaim 78, wherein the antidepressant administered in combination with the estrogen for the period of 5 to 8 consecutive days is administered in a daily amount equivalent to about 5 mg to about 20 mg of fiuoxetine hydrochloride.
80. The method of claim 73, wherein a one-time dose of an antidepressant is administered in combination with the estrogen.
8 . A method of contraception in a female in need thereof, said method comprising administering to said female a combination of estrogen and progestin for aperiod of 21 to 26 consecutive days, followed by administration of estrogen for a period of 2 to 10 consecutive days, wherein an antidepressant is administered (i) in combination with the estrogen for the period of 2 to 10 consecutive days, (ii) intermittently, (iii) one time, or (iv) once weekly.
82. The method of claim 81 , wherein the estrogen that is administered in combination with progestin for the period of 21 to 26 consecutive days is 57
administered in a daily amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol,
83. The method ofclaim 82, wherein the estrogen that is administered in combination with antidepressant for the period of 2 to 10 consecutive days is administered in a daily amount equivalent to about 5 μg to about 50 μg of ethinyl estradiol.
84. The method ofclaim 83, wherein the progestin that is administered in combination with estrogen for the period of 21 to 26 consecutive days is administered in a daily amount equivalent to about 0.05 mg to about 1.5 mg of levonorgestrel.
85. The method of claim 84, wherein the antidepressant that is administered in combination with estrogen for the period of 2 to 10 consecutive days is adrninistered in a daily amount equivalent to about 5 mg to about 120 mg of fiuoxetine hydrochloride.
86. The method ofclaim 83, wherein the estrogen is ethinyl estradiol, the progestin is levonorgestrel, and the antidepressant is fiuoxetine hydrochloride.
87. The method of claim 81, wherein the antidepressant is administered in combination with the estrogen or the combination of estrogen and progestin in a single tablet.
88. The method of claim 81, wherein the antidepressant is administered in combination with one dose of the estrogen or one dose of the combination of estrogen and progestin. 58
89. Themethod ofclaim 52, wherein the combination of estrogen and progestin is administered for a period of 25 consecutive days, and the combination of estrogen and antidepressant is administered for a period of 3 consecutive days.
90. A method of contraception in a female in need thereof, said method comprising administering to said female a combination of estrogen and progestin for a period of 25 consecutive days, followed by administration of estrogen of a period of 3 consecutive days,
91. A method of diminishing a premenstrual symptom in a female in need thereof, said method comprising administering to said female a combination of estrogen and progestin for a period of 25 consecutive days, followed by administration of estrogen of a period of 3 consecutive days.
92. The kit of claim 62, wherein the tablets comprising estrogen and progestin optionally combined with the antidepressant include 25 tablets, and wherein the tablets comprising estrogen optionally combined with the antidepressant include 3 tablets,
PCT/US2002/038602 2001-12-05 2002-12-04 Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology WO2003049744A1 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
SI200231034T SI1453521T1 (en) 2001-12-05 2002-12-04 Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology
DK02782404.4T DK1453521T3 (en) 2001-12-05 2002-12-04 ORAL PREVENTION TO AVOID PREGNANCY AND REDUCE PREMENSTRUAL SYMPTOMATOLOGY
ES02782404T ES2428118T3 (en) 2001-12-05 2002-12-04 Oral contraceptives to prevent pregnancy and reduce premenstrual symptoms
NZ533242A NZ533242A (en) 2001-12-05 2002-12-04 Oral extended regime contraceptive package
HU0402651A HU230759B1 (en) 2001-12-05 2002-12-04 Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology
MXPA04005445A MXPA04005445A (en) 2001-12-05 2002-12-04 Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology.
CA2468748A CA2468748C (en) 2001-12-05 2002-12-04 Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology
EP02782404.4A EP1453521B1 (en) 2001-12-05 2002-12-04 Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology
BR0214716A BRPI0214716B8 (en) 2001-12-05 2002-12-04 kit, preparations, and use of estrogen and progestin in the manufacture of a drug for use in preventing pregnancy
JP2003550793A JP2005516913A (en) 2001-12-05 2002-12-04 Oral contraceptives to prevent pregnancy and reduce premenstrual symptoms
IL16218202A IL162182A0 (en) 2001-12-05 2002-12-04 Kits containing oral contraceptives and methods utilizing the same
AU2002348272A AU2002348272B2 (en) 2001-12-05 2002-12-04 Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology
IL162182A IL162182A (en) 2001-12-05 2004-05-27 Kits containing oral contraceptives and methods utilizing the same
ZA2004/04249A ZA200404249B (en) 2001-12-05 2004-05-31 Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology
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Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5898032A (en) 1997-06-23 1999-04-27 Medical College Of Hampton Roads Ultra low dose oral contraceptives with less menstrual bleeding and sustained efficacy
PT1453521E (en) * 2001-12-05 2013-10-08 Teva Womens Health Inc Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology
US7005138B2 (en) * 2001-12-21 2006-02-28 Duramed Pharmaceuticals, Inc. Method of systematically delivering SSRIs
US20090163454A1 (en) * 2003-05-02 2009-06-25 Duramed Pharmaceuticals, Inc. Methods of Step-Down Hormone Treatment
CA2524474A1 (en) * 2003-05-02 2004-11-18 Duramed Pharmaceuticals, Inc. Methods of hormonal treatment utilizing extended cycle contraceptive regimens
US20040222123A1 (en) * 2003-05-06 2004-11-11 Barr Laboratories, Inc. Kit for pharmaceuticals
WO2005007112A2 (en) * 2003-07-16 2005-01-27 Duramed Pharmaceuticals, Inc. Methods of hormonal treatment utilizing contraceptive regimens with continuous estrogen administration
US7150355B2 (en) 2003-09-04 2006-12-19 Pharmadesign Inc. Case with pill receiving sleeves for storing and dispensing pills
EP1535618A1 (en) 2003-11-26 2005-06-01 Schering Aktiengesellschaft Pharmaceutical preparation for continuous hormonal treatment over a period of longer than 21-28 days comprising two estrogen and/or progestin compositions
CA2556459C (en) 2004-03-19 2013-01-15 Warner Chilcott Company, Inc. Extended cycle multiphasic oral contraceptive method
US20050250746A1 (en) * 2004-05-06 2005-11-10 Matthew Iammatteo Premenstrual dysphoric disorder medication
WO2005117898A1 (en) * 2004-05-26 2005-12-15 Wyeth Compositions and methods for treatment of premenstrual dysphoric disorder
CA2581932A1 (en) * 2004-09-27 2006-04-06 Pantarhei Bioscience B.V. A method of female contraception and a kit for use therein
US20070111975A1 (en) 2004-10-07 2007-05-17 Duramed Pharmaceuticals, Inc. Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens
EP2392333A1 (en) * 2004-10-07 2011-12-07 Teva Women's Health, Inc. Methods of hormonal treatment utilizing ascending-dose extended cycle regimens
US20060241092A1 (en) * 2005-04-15 2006-10-26 Anderson Freedolph D Contraceptive regimens for lower-weight women
TW200726473A (en) * 2005-06-28 2007-07-16 Wyeth Corp Compositions and methods for treatment of cycle-related symptoms
DE102005056527A1 (en) * 2005-11-25 2007-07-12 Grünenthal GmbH Use of a combination of ethinylestradiol and chlormadinone acetate for the manufacture of a medicament
DE102006003508A1 (en) * 2006-01-24 2007-07-26 Grünenthal GmbH Use of hormone combination of estrogen from ethinyl estradiol and metabolites of chlormadinone acetate, with chlormadione acetate as gestagen components, for producing medicament e.g. for preventing menstruation cycle-dependent mood
SG172654A1 (en) * 2006-03-02 2011-07-28 Warner Chilcott Co Llc Extended cycle multiphasic oral contraceptive method
US8399432B2 (en) * 2009-10-27 2013-03-19 Lipogen Ltd. Compositions and methods of treatment for alleviating premenstrual syndrome symptoms
US9517328B2 (en) 2013-06-19 2016-12-13 Kashiv Pharma, Llc Medicament applicator
AU2017330348B2 (en) 2016-09-22 2023-09-07 Alan B. Cash Method to alleviate the symptoms of PMS
US11679114B2 (en) 2021-07-26 2023-06-20 Navad Life Sciences Pte Progestogen-only oral contraception

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US428051A (en) * 1890-05-13 Wood-working machine
US575690A (en) * 1897-01-26 Match-safe
US3568828A (en) 1967-03-01 1971-03-09 Squibb & Sons Inc Modified sequential oral contraceptive
US4171358A (en) 1974-04-19 1979-10-16 Eli Lilly And Company Novel contraceptive method
US4145416A (en) 1976-06-23 1979-03-20 Schering, A.G. Novel agents and novel methods for treatment of climacteric disturbances
US4292315A (en) 1977-12-30 1981-09-29 Nichols Vorys Follicular phase estrogen or progestin with physiologic estrogen/progestin luteal phase replacement drug delivery system
US4215691A (en) * 1978-10-11 1980-08-05 Alza Corporation Vaginal contraceptive system made from block copolymer
US4291014A (en) 1979-01-11 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing estradiol diacetate
US4438139A (en) 1979-08-14 1984-03-20 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing estrogens
US4390531A (en) 1981-08-10 1983-06-28 Syntex Pharmaceuticals International Ltd. Method of contraception using peak progestogen dosage
USRE35724E (en) 1982-04-28 1998-02-03 Bio-Technology General Corp. Contraception system and method
US4921843A (en) * 1988-10-20 1990-05-01 Pasquale Samuel A Contraception system and method
US4826831A (en) 1983-08-05 1989-05-02 Pre Jay Holdings Limited Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens
US4544554A (en) 1983-09-26 1985-10-01 Ortho Pharmaceutical Corporation Triphasic oral contraceptive
US4530839A (en) 1983-09-26 1985-07-23 Ortho Pharmaceutical Corporation Triphasic oral contraceptive
US4628051A (en) 1983-09-26 1986-12-09 Ortho Pharmaceutical Corporation Triphasic oral contraceptive
US4616006A (en) 1983-09-26 1986-10-07 Ortho Pharmaceutical Corporation Triphasic oral contraceptive
US4736849A (en) 1983-12-19 1988-04-12 Leonard Walter G Calendar-oriented pill dispenser
US4534468A (en) 1983-12-19 1985-08-13 Nuckols Walter S Calendar-oriented pill dispenser
JPS60174716A (en) 1984-02-21 1985-09-09 Yamanouchi Pharmaceut Co Ltd Medicinal patch
US4962098A (en) 1987-06-15 1990-10-09 Warner-Lambert Company Graduated estrogen contraceptive
US5010070A (en) 1987-06-15 1991-04-23 Warner-Lambert Company Graduated estrogen contraceptive
US4752478A (en) 1984-12-17 1988-06-21 Merck & Co., Inc. Transdermal system for timolol
US5208225A (en) 1986-02-27 1993-05-04 Warner-Lambert Company Compositions containing fixed combinations
US4762717A (en) 1986-03-21 1988-08-09 The General Hospital Corporation Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use as a contraceptive
IE61236B1 (en) 1986-07-15 1994-10-19 American Home Prod Combination dosage form for pre-menopausal women
US5108995A (en) 1987-09-24 1992-04-28 Jencap Research Ltd. Hormone preparation and method
US5276022A (en) 1987-09-24 1994-01-04 Jencap Research Ltd. Hormone preparation and method
US5256421A (en) 1987-09-24 1993-10-26 Jencap Research Ltd. Hormone preparation and method
WO1989003692A1 (en) * 1987-10-22 1989-05-05 Massachusetts Institute Of Technology Treating premenstrual or late luteal phase syndrome
US4971998A (en) 1987-10-22 1990-11-20 Massachusetts Institute Of Technology Methods for treating the premenstrual or late luteal phase syndrome
US5043331A (en) 1989-06-15 1991-08-27 Orion-Yhtyma Oy Treatment of postmenopausal disorders
US5098714A (en) 1989-11-16 1992-03-24 Alza Corporation Osmotic, oral dosage form for fertility control
WO1992007824A1 (en) * 1990-10-25 1992-05-14 Schering Corporation Process for preparing florfenicol, its analogs and oxazoline intermediates thereto
IE71203B1 (en) 1990-12-13 1997-02-12 Akzo Nv Low estrogen oral contraceptives
DE4104385C1 (en) * 1991-02-09 1992-08-13 Marika Dr.Med. 6509 Framersheim De Ehrlich
US5211952A (en) 1991-04-12 1993-05-18 University Of Southern California Contraceptive methods and formulations for use therein
ZA924811B (en) 1991-06-28 1993-12-29 Endorecherche Inc Controlled release systems and low dose androgens
MX9301121A (en) * 1992-03-02 1993-09-01 Schering Ag METHOD AND EQUIPMENT FOR ORAL CONTRACEPTION AND REGULATION OF MENSTRUATION WITH ESTROGEN / PROGESTIN / ANIPROGESTIN.
DE4224534A1 (en) 1992-07-24 1994-01-27 Marika Dr Med Ehrlich Anti-ovulation agent for hormonal contraception
NL9301562A (en) 1993-09-09 1995-04-03 Saturnus Ag Substitution therapy preparation.
DE4344462C2 (en) 1993-12-22 1996-02-01 Schering Ag Composition for contraception
DE4344405C2 (en) * 1993-12-24 1995-12-07 Marika Dr Med Ehrlich Anti-ovulation agent and method for hormonal contraception
DE4411585A1 (en) 1994-03-30 1995-10-05 Schering Ag Combined pharmaceutical preparation for hormonal contraception
US5552394A (en) 1994-07-22 1996-09-03 The Medical College Of Hampton Roads Low dose oral contraceptives with less breakthrough bleeding and sustained efficacy
DE4429374C1 (en) 1994-08-12 1996-02-01 Jenapharm Gmbh Pharmaceutical preparations for contraception / hormone substitution with biogenic estrogen component
DE19513662A1 (en) 1995-04-08 1996-10-10 Schering Ag Combined pharmaceutical preparation for hormonal contraception
DE19525017A1 (en) 1995-06-28 1997-01-02 Schering Ag Pharmaceutical combination preparation, kit and method for hormonal contraception
FR2737411B1 (en) 1995-08-01 1997-10-17 Theramex NOVEL HORMONAL DRUGS AND THEIR USE FOR CORRECTING ESTROGENIC DEFICIENCIES
DE19531936A1 (en) 1995-08-17 1997-02-20 Schering Ag Combination preparation for contraception, containing kits and a method using them
DE19540253C2 (en) 1995-10-28 1998-06-04 Jenapharm Gmbh Multi-phase preparation for contraception based on natural estrogens
US5747480A (en) 1996-05-08 1998-05-05 American Home Products Corporation Oral contraceptive
US6139873A (en) 1996-07-10 2000-10-31 Cedars-Sinai Medical Center Combined pharmaceutical estrogen-androgen-progestin
AU3961697A (en) * 1996-07-26 1998-02-20 American Home Products Corporation Oral contraceptive
US6479475B1 (en) 1996-07-26 2002-11-12 Wyeth Oral contraceptive
AU3888597A (en) 1996-07-26 1998-02-20 American Home Products Corporation Oral contraceptive
AU3888697A (en) * 1996-07-26 1998-02-20 American Home Products Corporation Progestin/estrogen oral contraceptive
US5858405A (en) * 1996-07-26 1999-01-12 American Home Products Corporation Oral contraceptive
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
DE19705229C2 (en) 1997-02-12 1999-04-15 Hesch Rolf Dieter Prof Dr Med Use of three hormonal components for hormonal contraception for the treatment and / or prophylaxis of tumors of the mammary glands
EP0968188A1 (en) * 1997-03-20 2000-01-05 Basf Aktiengesellschaft Substituted 2-benz(o)ylpyridines, their preparation and their use as herbicides
US5898032A (en) 1997-06-23 1999-04-27 Medical College Of Hampton Roads Ultra low dose oral contraceptives with less menstrual bleeding and sustained efficacy
US6251956B1 (en) 1998-08-20 2001-06-26 Ortho Pharmaceutical Corporation Combination progestin oral contraceptive regimen
DE19739916C2 (en) 1997-09-11 2001-09-13 Hesch Rolf Dieter Use of a combination of a progestogen and an estrogen for the continuous inhibition of ovulation and possibly simultaneous treatment and / or prophylaxis of tumors of the mammary glands
EP1011681A1 (en) 1997-09-12 2000-06-28 American Home Products Corporation Oral contraceptive preparation having a first phase comprising progestin/estrogen and a second phase comprising progestin
US6306914B1 (en) 1997-10-21 2001-10-23 Columbia Laboratories, Inc. Progestin therapy for maintaining amenorrhea
US6265393B1 (en) 1998-08-07 2001-07-24 Heinrichs William Leroy Prevention of endometriosis signs or symptons
US6214815B1 (en) 1998-12-23 2001-04-10 Ortho-Mcneil Pharmaceuticals, Inc. Triphasic oral contraceptive
US6787531B1 (en) 1999-08-31 2004-09-07 Schering Ag Pharmaceutical composition for use as a contraceptive
US20020132801A1 (en) 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
US20010044431A1 (en) 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
CA2414938A1 (en) * 2000-07-06 2002-01-17 Simon Nicholas Jenkins Combinations of ssri and estrogenic agents
EP1390038A2 (en) 2001-05-16 2004-02-25 Endeavor Pharmaceuticals Treatment of conditions relating to hormone deficiencies by administration of progestins
US20030018018A1 (en) 2001-07-10 2003-01-23 Medical College Of Hampton Roads Ultra low dose oral contraceptives with sustained efficacy and induced amenorrhea
PT1453521E (en) 2001-12-05 2013-10-08 Teva Womens Health Inc Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology
ES2197801B1 (en) * 2002-03-05 2005-03-16 Ferrer Internacional,S.A PROCEDURE FOR OBTAINING THE 3- (2- (4- (6-FLUORO-BENZO (D) ISOXAZOL-3-IL) PIPERIDIN-1-IL) -ETIL) -2-METHYL-6,7,8,9- TETRAHIDRO-4H-PIRIDO- (1,2-A) PIRIMIDIN-4-ONA.
WO2003077924A1 (en) 2002-03-11 2003-09-25 Janssen Pharmaceutica N.V. Continuous sulfatase inhibiting progestogen hormone replacement therapy
US20030219471A1 (en) 2002-03-11 2003-11-27 Caubel Patrick Michel Extended cycle estrogen and sulfatase inhibiting progestogen contraceptive regimens
US20040142914A1 (en) 2002-03-11 2004-07-22 Friedman Andrew Joseph Extended transdermal contraceptive regimens
US20030216366A1 (en) 2002-04-03 2003-11-20 Leonard Thomas W. Step-down estrogen therapy
CA2524474A1 (en) 2003-05-02 2004-11-18 Duramed Pharmaceuticals, Inc. Methods of hormonal treatment utilizing extended cycle contraceptive regimens
US20040251301A1 (en) 2003-05-05 2004-12-16 Niemann Amy C. Device for calculating anticipated days for menstruation
US20040222123A1 (en) 2003-05-06 2004-11-11 Barr Laboratories, Inc. Kit for pharmaceuticals
WO2005007112A2 (en) * 2003-07-16 2005-01-27 Duramed Pharmaceuticals, Inc. Methods of hormonal treatment utilizing contraceptive regimens with continuous estrogen administration
US7150355B2 (en) 2003-09-04 2006-12-19 Pharmadesign Inc. Case with pill receiving sleeves for storing and dispensing pills
CA2540697A1 (en) 2003-10-01 2005-04-14 Janssen Pharmaceutica N.V. Extended triphasic contraceptive regimens
US20070111975A1 (en) 2004-10-07 2007-05-17 Duramed Pharmaceuticals, Inc. Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens
EP2392333A1 (en) 2004-10-07 2011-12-07 Teva Women's Health, Inc. Methods of hormonal treatment utilizing ascending-dose extended cycle regimens
EP1983999A4 (en) * 2006-01-27 2010-10-20 Teva Womens Health Inc Regimens for treatment of conditions related to estrogen deficiency

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