WO2003050250A3 - Chondrocyte precursors derived from human embryonic stem cells - Google Patents
Chondrocyte precursors derived from human embryonic stem cells Download PDFInfo
- Publication number
- WO2003050250A3 WO2003050250A3 PCT/US2002/039090 US0239090W WO03050250A3 WO 2003050250 A3 WO2003050250 A3 WO 2003050250A3 US 0239090 W US0239090 W US 0239090W WO 03050250 A3 WO03050250 A3 WO 03050250A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stem cells
- chondrocyte
- embryonic stem
- human embryonic
- cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/44—Thiols, e.g. mercaptoethanol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/395—Thyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL16213202A IL162132A0 (en) | 2001-12-07 | 2002-12-06 | Chondrocyte precursors derived from human embryonic stem cells |
CA2468335A CA2468335C (en) | 2001-12-07 | 2002-12-06 | Chondrocyte precursors derived from human embryonic stem cells |
EP02804739A EP1463800A4 (en) | 2001-12-07 | 2002-12-06 | Chondrocyte precursors derived from human embryonic stem cells |
JP2003551272A JP2005511083A (en) | 2001-12-07 | 2002-12-06 | Chondrocyte progenitor cells derived from human embryonic stem cells |
GB0414956A GB2399348A (en) | 2001-12-07 | 2002-12-06 | Chondrocyte precursors derived from human embryonic stem cells |
AU2002366602A AU2002366602B2 (en) | 2001-12-07 | 2002-12-06 | Chondrocyte precursors derived from human embryonic stem cells |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33904301P | 2001-12-07 | 2001-12-07 | |
US60/339,043 | 2001-12-07 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2003050250A2 WO2003050250A2 (en) | 2003-06-19 |
WO2003050250A3 true WO2003050250A3 (en) | 2004-02-12 |
WO2003050250B1 WO2003050250B1 (en) | 2004-04-15 |
Family
ID=23327241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/039090 WO2003050250A2 (en) | 2001-12-07 | 2002-12-06 | Chondrocyte precursors derived from human embryonic stem cells |
Country Status (10)
Country | Link |
---|---|
US (5) | US20030109038A1 (en) |
EP (1) | EP1463800A4 (en) |
JP (1) | JP2005511083A (en) |
KR (1) | KR100973453B1 (en) |
CN (1) | CN1599793A (en) |
AU (1) | AU2002366602B2 (en) |
CA (1) | CA2468335C (en) |
GB (1) | GB2399348A (en) |
IL (1) | IL162132A0 (en) |
WO (1) | WO2003050250A2 (en) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
IL162132A0 (en) * | 2001-12-07 | 2005-11-20 | Geron Corp | Chondrocyte precursors derived from human embryonic stem cells |
ES2571355T3 (en) | 2002-12-16 | 2016-05-24 | Technion Res & Dev Foundation | Culture system without feeder cells or xenocontaminants for human embryonic stem cells |
US20050106725A1 (en) * | 2003-11-19 | 2005-05-19 | Palecek Sean P. | Method of reducing cell differentiation |
US8637065B2 (en) | 2004-07-09 | 2014-01-28 | William Marsh Rice University | Dermis-derived cells for tissue engineering applications |
AU2005271723B2 (en) | 2004-07-13 | 2010-12-16 | Asterias Biotherapeutics, Inc. | Medium for growing human embryonic stem cells |
US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
WO2007002086A2 (en) | 2005-06-22 | 2007-01-04 | Geron Corporation | Suspension culture of human embryonic stem cells |
GB0513777D0 (en) * | 2005-07-06 | 2005-08-10 | Univ Bristol | Methods for tissue engineering |
EP1962719A4 (en) | 2005-08-29 | 2011-05-04 | Technion Res And Dev Of Foundation Ltd | Media for culturing stem cells |
JP4977854B2 (en) * | 2005-10-21 | 2012-07-18 | 国立大学法人名古屋大学 | Composite material for tissue formation and method for producing the same |
US8241902B2 (en) * | 2006-01-11 | 2012-08-14 | Technion Research & Development Foundation Ltd. | Preparation of adult stem cell-derived connective tissue progenitors |
AU2007254048A1 (en) * | 2006-04-05 | 2007-11-29 | William Marsh Rice University | Dermis-derived cells for tissue engineering applications |
EP3441459B1 (en) | 2006-08-02 | 2021-03-17 | Technion Research & Development Foundation Limited | Methods of expanding embryonic stem cells in a suspension culture |
CN101657536B (en) | 2007-01-23 | 2016-06-01 | 公立大学法人横浜市立大学 | Method for preparation of cartilage cell |
WO2008096842A1 (en) * | 2007-02-09 | 2008-08-14 | Osaka University | Method for screening of substance for prevention or treatment of degenerative disease |
US8574567B2 (en) | 2007-05-03 | 2013-11-05 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
EP2607477B1 (en) | 2007-05-03 | 2020-09-23 | The Brigham and Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
WO2009106642A1 (en) * | 2008-02-29 | 2009-09-03 | Coloplast A/S | Biosynthetic cartilaginous matrix and methods for their production |
EP2698173A1 (en) | 2008-02-29 | 2014-02-19 | Coloplast A/S | Compositions and methods for augmentation and regeneration of living tissue in a subject |
EP2268794B1 (en) * | 2008-03-27 | 2017-09-13 | Asterias Biotherapeutics, Inc. | Differentiation of primate pluripotent stem cells to hematopoietic lineage cells |
AU2010266016B2 (en) | 2009-06-25 | 2016-05-26 | Asterias Biotherapeutics, Inc. | Differentiated pluripotent stem cell progeny depleted of extraneous phenotypes |
KR101135636B1 (en) * | 2009-10-27 | 2012-04-17 | 서울대학교산학협력단 | Method for producing mesenchymal stem cells from human pluripotent stem cells and mesenchymal stem cells produced by thereof |
CA2783437C (en) | 2009-11-12 | 2020-08-04 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
JP6263329B2 (en) * | 2009-11-24 | 2018-01-17 | ザ ユニバーシティ オブ コネチカット | Differentiation of human embryonic and induced pluripotent stem cells |
US9029145B2 (en) | 2010-04-08 | 2015-05-12 | The University Court Of The University Of Edinburgh | Chondrogenic progenitor cells, protocol for derivation of cells and uses thereof |
ES2370794B1 (en) * | 2010-05-25 | 2012-10-31 | Servicio Andaluz De Salud | BIOMARCATOR OF HUMAN CARTILAGIN CELLS. |
WO2011159797A2 (en) | 2010-06-15 | 2011-12-22 | Cellular Dynamics International, Inc. | A compendium of ready-built stem cell models for interrogation of biological response |
US20130122589A1 (en) * | 2010-07-26 | 2013-05-16 | The University Of Manchester | Targeted differentiation of stem cells |
DE102010033565B4 (en) * | 2010-07-27 | 2012-06-21 | Tetec Tissue Engineering Technologies Ag | Marker for the determination of chondrocytes |
US20140329314A1 (en) | 2011-03-29 | 2014-11-06 | Christopher O'Sullivan | Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells |
LT2753346T (en) | 2011-09-07 | 2020-08-10 | Mount Sinai School Of Medicine | Ceramidase and cell differentiation |
EP2875125B1 (en) | 2012-07-20 | 2018-10-24 | Alfred C. Kuo | Methods for producing cartilage and bone |
WO2015064754A1 (en) * | 2013-11-01 | 2015-05-07 | 国立大学法人京都大学 | Novel chondrocyte induction method |
CN106967686B (en) * | 2017-03-31 | 2019-11-08 | 北昊干细胞与再生医学研究院有限公司 | The method and human tissue of the external lengthening of telomeres Multiplying culture of cartilage cell are engineered regeneration of cartilage |
CA3141455A1 (en) | 2019-05-20 | 2020-11-26 | Ajinomoto Co., Inc. | Expansion culture method for cartilage or bone precursor cells |
KR102307115B1 (en) * | 2021-05-12 | 2021-10-01 | 주식회사 스마트셀랩 | Ciprofloxacin leading to induce mesenchymal stem cell into chondrocyte progenitor cell and differentiate into chondrocyte |
WO2023018244A1 (en) * | 2021-08-12 | 2023-02-16 | 주식회사 유스바이오글로벌 | Composition for treatment of cartilage-related disease and preparation method therefor |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6174333B1 (en) * | 1994-06-06 | 2001-01-16 | Osiris Therapeutics, Inc. | Biomatrix for soft tissue regeneration using mesenchymal stem cells |
US6200806B1 (en) * | 1995-01-20 | 2001-03-13 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
US6245566B1 (en) * | 1997-03-31 | 2001-06-12 | The Johns Hopkins University School Of Medicine | Human embryonic germ cell line and methods of use |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4439521A (en) * | 1981-10-21 | 1984-03-27 | Ontario Cancer Institute | Method for producing self-reproducing mammalian pancreatic islet-like structures |
GB8604497D0 (en) * | 1986-02-24 | 1986-04-03 | Connaught Lab | Separation of islets of langerhans |
JP2813467B2 (en) * | 1993-04-08 | 1998-10-22 | ヒューマン・セル・カルチャーズ・インコーポレーテッド | Cell culture methods and media |
GB9425071D0 (en) | 1994-12-13 | 1995-02-08 | Stringer Bradley M J | Chondrocyte cell lines |
US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
US5679565A (en) * | 1995-04-10 | 1997-10-21 | The Regents Of The University Of California | Method of preserving pancreatic islets |
WO1997018299A1 (en) * | 1995-11-16 | 1997-05-22 | Case Western Reserve University | In vitro chondrogenic induction of human mesenchymal stem cells |
JP3638614B2 (en) * | 1996-07-25 | 2005-04-13 | ジェンザイム・コーポレーション | Chondrocyte medium composition and culture method |
US6090622A (en) * | 1997-03-31 | 2000-07-18 | The Johns Hopkins School Of Medicine | Human embryonic pluripotent germ cells |
AU7813998A (en) | 1997-06-04 | 1998-12-21 | Genzyme Corporation | Methods for chondrocyte growth and differentiation |
US6800480B1 (en) * | 1997-10-23 | 2004-10-05 | Geron Corporation | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
US6197586B1 (en) * | 1997-12-12 | 2001-03-06 | The Regents Of The University Of California | Chondrocyte-like cells useful for tissue engineering and methods |
US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
US7410798B2 (en) * | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
RU2272839C2 (en) | 1998-11-09 | 2006-03-27 | Консорцио Пер Ла Джестионе Дель Чентро Ди Биотекнолоджие Аванцате | Serum-free medium for cultured cells used for reconstruction of osseous and cartilage segments (variants) |
US6663870B2 (en) * | 1998-12-07 | 2003-12-16 | Zymogenetics, Inc. | Methods for promoting growth of bone using zvegf3 |
AU780794B2 (en) * | 1999-02-10 | 2005-04-14 | Es Cell International Pte Ltd | Pancreatic progenitor cells, methods and uses related thereto |
AU3227000A (en) | 1999-02-10 | 2000-08-29 | Ontogeny, Inc. | Methods of inducing insulin positive progenitor cells |
US6774120B1 (en) | 1999-06-01 | 2004-08-10 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
EP1185622A4 (en) | 1999-06-23 | 2002-09-18 | Joslin Diabetes Center Inc | Methods of making pancreatic islet cells |
JP2003505198A (en) | 1999-08-02 | 2003-02-12 | フェリゲン トランスプランタツィオン セルヴィス インターナツィオナール アーゲー | Kit for cell transplantation in cartilage matrix |
CN100475953C (en) | 1999-12-06 | 2009-04-08 | 通用医疗公司 | Pancreatic stem cells |
US6436704B1 (en) | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
DE60143517D1 (en) | 2000-04-25 | 2011-01-05 | Osiris Therapeutics Inc | RESTORING THE RACES WITH MESENCHYMAL STEM CELLS |
IL162132A0 (en) * | 2001-12-07 | 2005-11-20 | Geron Corp | Chondrocyte precursors derived from human embryonic stem cells |
-
2002
- 2002-12-06 IL IL16213202A patent/IL162132A0/en not_active IP Right Cessation
- 2002-12-06 WO PCT/US2002/039090 patent/WO2003050250A2/en active Application Filing
- 2002-12-06 KR KR1020047008714A patent/KR100973453B1/en active IP Right Grant
- 2002-12-06 CA CA2468335A patent/CA2468335C/en not_active Expired - Fee Related
- 2002-12-06 US US10/313,740 patent/US20030109038A1/en not_active Abandoned
- 2002-12-06 GB GB0414956A patent/GB2399348A/en not_active Withdrawn
- 2002-12-06 EP EP02804739A patent/EP1463800A4/en not_active Withdrawn
- 2002-12-06 CN CNA028243684A patent/CN1599793A/en active Pending
- 2002-12-06 JP JP2003551272A patent/JP2005511083A/en active Pending
- 2002-12-06 AU AU2002366602A patent/AU2002366602B2/en not_active Ceased
-
2006
- 2006-02-01 US US11/345,878 patent/US7906330B2/en not_active Expired - Fee Related
-
2011
- 2011-02-04 US US13/021,497 patent/US8546101B2/en not_active Expired - Fee Related
-
2013
- 2013-08-30 US US14/015,040 patent/US20140134721A1/en not_active Abandoned
-
2018
- 2018-01-22 US US15/877,301 patent/US20190024053A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6174333B1 (en) * | 1994-06-06 | 2001-01-16 | Osiris Therapeutics, Inc. | Biomatrix for soft tissue regeneration using mesenchymal stem cells |
US6200806B1 (en) * | 1995-01-20 | 2001-03-13 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
US6245566B1 (en) * | 1997-03-31 | 2001-06-12 | The Johns Hopkins University School Of Medicine | Human embryonic germ cell line and methods of use |
Non-Patent Citations (3)
Title |
---|
CONNOR J.R. ET AL.: "Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization", OSTEOARTHRITIS AND CARTILAGE, vol. 8, 2000, pages 87 - 95, XP002965904 * |
NIIDA H. ET AL.: "Severe growth defect in mouse cells lacking the telomerase RNA component", NATURE GENETICS, vol. 19, June 1998 (1998-06-01), pages 203 - 206, XP002965905 * |
THOMSON J.A. ET AL.: "Isolation of a primate embryonic stem cell line", PROC. NATL. ACAD. SCI. USA, vol. 92, August 1995 (1995-08-01), pages 7844 - 7848, XP000604992 * |
Also Published As
Publication number | Publication date |
---|---|
US8546101B2 (en) | 2013-10-01 |
US20190024053A1 (en) | 2019-01-24 |
EP1463800A4 (en) | 2006-04-26 |
CA2468335A1 (en) | 2003-06-19 |
US20060148077A1 (en) | 2006-07-06 |
CA2468335C (en) | 2014-07-08 |
CN1599793A (en) | 2005-03-23 |
US7906330B2 (en) | 2011-03-15 |
JP2005511083A (en) | 2005-04-28 |
IL162132A0 (en) | 2005-11-20 |
US20140134721A1 (en) | 2014-05-15 |
EP1463800A2 (en) | 2004-10-06 |
AU2002366602A1 (en) | 2003-06-23 |
WO2003050250B1 (en) | 2004-04-15 |
GB2399348A (en) | 2004-09-15 |
US20110129867A1 (en) | 2011-06-02 |
WO2003050250A2 (en) | 2003-06-19 |
US20030109038A1 (en) | 2003-06-12 |
AU2002366602B2 (en) | 2008-07-03 |
GB0414956D0 (en) | 2004-08-04 |
KR20050044733A (en) | 2005-05-12 |
KR100973453B1 (en) | 2010-08-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2003050250A3 (en) | Chondrocyte precursors derived from human embryonic stem cells | |
WO2004044158A3 (en) | Human embryonic stem cell cultures, and compositions and methods for growing same | |
WO2003014313A3 (en) | Alternative compositions and methods for the culture of stem cells | |
WO2007051038A3 (en) | Pdx1-expressing dorsal and ventral foregut endoderm | |
WO2001036589A3 (en) | Human ex vivo immune system | |
EP1360314A4 (en) | Chemically defined medium for cultured mammalian cells | |
IL210618A (en) | Cell cultures comprising isolated expanded human non-embryonic non-germ cells, pharmaceutical compositions comprising the same, methods for their preparation and methods for identifying modulators and differentiation factors | |
GB2394723A (en) | Culture system for rapid expansion of human embryonic stem cells | |
BR0015148A (en) | Androgenetic or gynogenetic production of pluripotent cell and cell lines, and their use to produce differentiated tissues and cells | |
SG145530A1 (en) | Differentiated human embryoid cells and a method for producing them | |
EP1077254A3 (en) | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof | |
EP1165830A4 (en) | Adipose-derived stem cells and lattices | |
WO2006044204A3 (en) | Neuronal progenitors from feeder-free human embryonic stem cell culture | |
WO2003018760A3 (en) | Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy | |
SG152273A1 (en) | Pdx1 expressing endoderm | |
WO2003050249A3 (en) | Islet cells from human embryonic stem cells | |
EP1572961A4 (en) | Actriib fusion polypeptides and uses therefor | |
CA2356024A1 (en) | Process for the production of human cartilage implants by means of chondrocytes cultivated in vitro | |
WO2004113513A3 (en) | Methods and compositions for modulating stem cell growth and differentiation | |
HK1080111A1 (en) | Method for growth of human conjunctival tissue equivalents for research, clinical ocular surface transplantation and tissue engineering | |
WO2003020919A3 (en) | A unit and a process for carrying out high cell density fermentation | |
WO2007011610A3 (en) | Protein formulation for promoting hard tissue formation | |
EP3031326A3 (en) | Bone marrow-derived mesenchymal stem cells as a source of neural progenitors | |
WO2007051625A3 (en) | Compositions and methods for producing pluripotent cells from adult testis | |
CN101198691A (en) | Isolation of multi-lineage stem cells |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
ENP | Entry into the national phase |
Ref document number: 0414956 Country of ref document: GB Kind code of ref document: A Free format text: PCT FILING DATE = 20021206 |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
B | Later publication of amended claims |
Effective date: 20030812 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 162132 Country of ref document: IL |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2468335 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020047008714 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 20028243684 Country of ref document: CN Ref document number: 2003551272 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002366602 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1794/DELNP/2004 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002804739 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2002804739 Country of ref document: EP |