WO2003051191A1 - Method and device for monitoring analyte concentration by optical detection - Google Patents
Method and device for monitoring analyte concentration by optical detection Download PDFInfo
- Publication number
- WO2003051191A1 WO2003051191A1 PCT/EP2002/014141 EP0214141W WO03051191A1 WO 2003051191 A1 WO2003051191 A1 WO 2003051191A1 EP 0214141 W EP0214141 W EP 0214141W WO 03051191 A1 WO03051191 A1 WO 03051191A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- areas
- light
- detection means
- compounds
- tissue
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 24
- 238000001514 detection method Methods 0.000 title claims description 35
- 230000003287 optical effect Effects 0.000 title abstract description 16
- 239000012491 analyte Substances 0.000 title description 3
- 238000012544 monitoring process Methods 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 58
- 238000004458 analytical method Methods 0.000 claims abstract description 25
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 20
- 239000008103 glucose Substances 0.000 claims abstract description 20
- 239000012528 membrane Substances 0.000 claims description 14
- 125000006850 spacer group Chemical group 0.000 claims description 12
- 238000002513 implantation Methods 0.000 claims description 5
- 239000000560 biocompatible material Substances 0.000 claims description 4
- 230000023077 detection of light stimulus Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 230000003993 interaction Effects 0.000 abstract description 10
- 239000008280 blood Substances 0.000 abstract description 9
- 210000004369 blood Anatomy 0.000 abstract description 9
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 6
- 238000005259 measurement Methods 0.000 description 25
- 230000005540 biological transmission Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000003149 assay kit Methods 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000007405 data analysis Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- YPOMYLVHIZEIIO-UHFFFAOYSA-N C1C[IH]CCNC1 Chemical compound C1C[IH]CCNC1 YPOMYLVHIZEIIO-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000000746 body region Anatomy 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 210000000624 ear auricle Anatomy 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- -1 glucose Chemical class 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012806 monitoring device Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000002161 passivation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Emergency Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE60228755T DE60228755D1 (en) | 2001-12-17 | 2002-12-12 | METHOD AND DEVICE FOR MONITORING ANALYZ CONCENTRATION BY OPTICAL DETECTION |
US10/499,596 US7248906B2 (en) | 2001-12-17 | 2002-12-12 | Method and device for monitoring analyte concentration by optical detection |
EP02791814A EP1455641B1 (en) | 2001-12-17 | 2002-12-12 | Method and device for monitoring analyte concentration by optical detection |
AU2002358128A AU2002358128A1 (en) | 2001-12-17 | 2002-12-12 | Method and device for monitoring analyte concentration by optical detection |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200101904 | 2001-12-17 | ||
DKPA200101892 | 2001-12-17 | ||
DKPA200101892 | 2001-12-17 | ||
DKPA200101904 | 2001-12-17 | ||
DKPA200200224 | 2002-02-14 | ||
DKPA200200224 | 2002-02-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003051191A1 true WO2003051191A1 (en) | 2003-06-26 |
Family
ID=27222572
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/014141 WO2003051191A1 (en) | 2001-12-17 | 2002-12-12 | Method and device for monitoring analyte concentration by optical detection |
Country Status (6)
Country | Link |
---|---|
US (1) | US7248906B2 (en) |
EP (1) | EP1455641B1 (en) |
AT (1) | ATE406835T1 (en) |
AU (1) | AU2002358128A1 (en) |
DE (1) | DE60228755D1 (en) |
WO (1) | WO2003051191A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2516259A (en) * | 2013-07-16 | 2015-01-21 | Nokia Corp | An apparatus, method and computer program for detecting physiological parameters |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
US8527026B2 (en) | 1997-03-04 | 2013-09-03 | Dexcom, Inc. | Device and method for determining analyte levels |
US20030032874A1 (en) | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
US7828728B2 (en) | 2003-07-25 | 2010-11-09 | Dexcom, Inc. | Analyte sensor |
US7226978B2 (en) | 2002-05-22 | 2007-06-05 | Dexcom, Inc. | Techniques to improve polyurethane membranes for implantable glucose sensors |
US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
WO2007120442A2 (en) | 2003-07-25 | 2007-10-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US7074307B2 (en) | 2003-07-25 | 2006-07-11 | Dexcom, Inc. | Electrode systems for electrochemical sensors |
JP4708342B2 (en) | 2003-07-25 | 2011-06-22 | デックスコム・インコーポレーテッド | Oxygen augmentation membrane system for use in implantable devices |
US9135402B2 (en) | 2007-12-17 | 2015-09-15 | Dexcom, Inc. | Systems and methods for processing sensor data |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US20050090607A1 (en) * | 2003-10-28 | 2005-04-28 | Dexcom, Inc. | Silicone composition for biocompatible membrane |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
EP1711790B1 (en) | 2003-12-05 | 2010-09-08 | DexCom, Inc. | Calibration techniques for a continuous analyte sensor |
US8277713B2 (en) | 2004-05-03 | 2012-10-02 | Dexcom, Inc. | Implantable analyte sensor |
WO2006127694A2 (en) | 2004-07-13 | 2006-11-30 | Dexcom, Inc. | Analyte sensor |
US7654956B2 (en) | 2004-07-13 | 2010-02-02 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8744546B2 (en) | 2005-05-05 | 2014-06-03 | Dexcom, Inc. | Cellulosic-based resistance domain for an analyte sensor |
US7809441B2 (en) * | 2006-05-17 | 2010-10-05 | Cardiac Pacemakers, Inc. | Implantable medical device with chemical sensor and related methods |
ATE416526T1 (en) * | 2006-08-25 | 2008-12-15 | Alcatel Lucent | DIGITAL SIGNAL RECEIVER WITH Q-FACTOR MONITORING |
US20200037874A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US8417312B2 (en) | 2007-10-25 | 2013-04-09 | Dexcom, Inc. | Systems and methods for processing sensor data |
US8290557B2 (en) * | 2007-12-12 | 2012-10-16 | Medtronic, Inc. | Implantable optical sensor and method for use |
US8290559B2 (en) | 2007-12-17 | 2012-10-16 | Dexcom, Inc. | Systems and methods for processing sensor data |
US20090247856A1 (en) * | 2008-03-28 | 2009-10-01 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US11730407B2 (en) | 2008-03-28 | 2023-08-22 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US8682408B2 (en) | 2008-03-28 | 2014-03-25 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US8583204B2 (en) | 2008-03-28 | 2013-11-12 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US20110120212A1 (en) * | 2008-03-31 | 2011-05-26 | P&V Consulting Gmbh & Co. Kg | System for determining a concentration of a substance in a body fluid |
WO2010033724A2 (en) | 2008-09-19 | 2010-03-25 | Dexcom, Inc. | Particle-containing membrane and particulate electrode for analyte sensors |
ES2338624B1 (en) | 2008-11-07 | 2011-09-13 | Sabirmedical,S.L. | SYSTEM AND APPARATUS FOR NON-INVASIVE MEASUREMENT OF GLUCOSE LEVELS IN BLOOD. |
US10716500B2 (en) | 2015-06-29 | 2020-07-21 | Cardiac Pacemakers, Inc. | Systems and methods for normalization of chemical sensor data based on fluid state changes |
CN108968976B (en) | 2017-05-31 | 2022-09-13 | 心脏起搏器股份公司 | Implantable medical device with chemical sensor |
CN109381195B (en) | 2017-08-10 | 2023-01-10 | 心脏起搏器股份公司 | Systems and methods including electrolyte sensor fusion |
CN109419515B (en) | 2017-08-23 | 2023-03-24 | 心脏起搏器股份公司 | Implantable chemical sensor with staged activation |
CN109864746B (en) | 2017-12-01 | 2023-09-29 | 心脏起搏器股份公司 | Multimode analyte sensor for medical devices |
CN109864747B (en) | 2017-12-05 | 2023-08-25 | 心脏起搏器股份公司 | Multimode analyte sensor optoelectronic interface |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6011984A (en) * | 1995-11-22 | 2000-01-04 | Minimed Inc. | Detection of biological molecules using chemical amplification and optical sensors |
WO2000033065A1 (en) * | 1998-12-02 | 2000-06-08 | Ut-Battelle, Llc | In vivo biosensor apparatus and method of use |
WO2001066005A1 (en) * | 2000-03-08 | 2001-09-13 | Disetronic Licensing Ag | Device for in-vivo measurement of the concentration of a substance contained in a body fluid |
US20020161286A1 (en) * | 2001-03-16 | 2002-10-31 | Martin Gerber | Subcutaneous analyte sensor |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2245092A (en) | 1991-12-31 | 1993-07-28 | Vivascan Corporation | Blood constituent determination based on differential spectral analysis |
AT397458B (en) * | 1992-09-25 | 1994-04-25 | Avl Verbrennungskraft Messtech | SENSOR ARRANGEMENT |
US5995860A (en) * | 1995-07-06 | 1999-11-30 | Thomas Jefferson University | Implantable sensor and system for measurement and control of blood constituent levels |
US5833603A (en) * | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
US6507747B1 (en) | 1998-12-02 | 2003-01-14 | Board Of Regents, The University Of Texas System | Method and apparatus for concomitant structural and biochemical characterization of tissue |
-
2002
- 2002-12-12 US US10/499,596 patent/US7248906B2/en not_active Expired - Fee Related
- 2002-12-12 AT AT02791814T patent/ATE406835T1/en not_active IP Right Cessation
- 2002-12-12 AU AU2002358128A patent/AU2002358128A1/en not_active Abandoned
- 2002-12-12 EP EP02791814A patent/EP1455641B1/en not_active Expired - Lifetime
- 2002-12-12 WO PCT/EP2002/014141 patent/WO2003051191A1/en active IP Right Grant
- 2002-12-12 DE DE60228755T patent/DE60228755D1/en not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6011984A (en) * | 1995-11-22 | 2000-01-04 | Minimed Inc. | Detection of biological molecules using chemical amplification and optical sensors |
WO2000033065A1 (en) * | 1998-12-02 | 2000-06-08 | Ut-Battelle, Llc | In vivo biosensor apparatus and method of use |
WO2001066005A1 (en) * | 2000-03-08 | 2001-09-13 | Disetronic Licensing Ag | Device for in-vivo measurement of the concentration of a substance contained in a body fluid |
US20020161286A1 (en) * | 2001-03-16 | 2002-10-31 | Martin Gerber | Subcutaneous analyte sensor |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2516259A (en) * | 2013-07-16 | 2015-01-21 | Nokia Corp | An apparatus, method and computer program for detecting physiological parameters |
US10413241B2 (en) | 2013-07-16 | 2019-09-17 | Nokia Technologies Oy | Apparatus, method and computer program for detecting physiological parameters |
Also Published As
Publication number | Publication date |
---|---|
AU2002358128A1 (en) | 2003-06-30 |
EP1455641A1 (en) | 2004-09-15 |
US20050070770A1 (en) | 2005-03-31 |
ATE406835T1 (en) | 2008-09-15 |
DE60228755D1 (en) | 2008-10-16 |
US7248906B2 (en) | 2007-07-24 |
EP1455641B1 (en) | 2008-09-03 |
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