WO2003054161A3 - USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS - Google Patents

USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS Download PDF

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Publication number
WO2003054161A3
WO2003054161A3 PCT/US2002/040955 US0240955W WO03054161A3 WO 2003054161 A3 WO2003054161 A3 WO 2003054161A3 US 0240955 W US0240955 W US 0240955W WO 03054161 A3 WO03054161 A3 WO 03054161A3
Authority
WO
WIPO (PCT)
Prior art keywords
inducing
tissue
cell
induce angiogenesis
cpg oligodeoxynucleotides
Prior art date
Application number
PCT/US2002/040955
Other languages
French (fr)
Other versions
WO2003054161A2 (en
Inventor
Dennis M Klinman
Mei Zheng
Barry T Rouse
Original Assignee
Us Gov Health & Human Serv
Univ Tennessee Res Corp
Dennis M Klinman
Mei Zheng
Barry T Rouse
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Univ Tennessee Res Corp, Dennis M Klinman, Mei Zheng, Barry T Rouse filed Critical Us Gov Health & Human Serv
Priority to US10/499,597 priority Critical patent/US7615227B2/en
Priority to AU2002366710A priority patent/AU2002366710A1/en
Publication of WO2003054161A2 publication Critical patent/WO2003054161A2/en
Publication of WO2003054161A3 publication Critical patent/WO2003054161A3/en
Priority to US11/839,217 priority patent/US7935351B2/en
Priority to US12/205,756 priority patent/US8466116B2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

This disclosure provides a method of inducing production of vascular endothelial growth factor by a cell. The method includes contacting the cell with a CpG oligonucleotide, thereby inducing the production of vascular endothelial growth factor by the cell. The disclosure further provides a method inducing neovascularization in a tissue. This method includes comprising introducing a CpG oligodeoxynucleotide into an area of the tissue wherein the formation of new blood vessels is desired, thereby inducing neovascularization in the area of the tissue.
PCT/US2002/040955 2001-12-20 2002-12-19 USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS WO2003054161A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/499,597 US7615227B2 (en) 2001-12-20 2002-12-19 Use of CpG oligodeoxynucleotides to induce angiogenesis
AU2002366710A AU2002366710A1 (en) 2001-12-20 2002-12-19 USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS
US11/839,217 US7935351B2 (en) 2001-12-20 2007-08-15 Use of CPG oligodeoxynucleotides to induce angiogenesis
US12/205,756 US8466116B2 (en) 2001-12-20 2008-09-05 Use of CpG oligodeoxynucleotides to induce epithelial cell growth

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34345701P 2001-12-20 2001-12-20
US60/343,457 2001-12-20

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10499597 A-371-Of-International 2002-12-19
US11/839,217 Continuation US7935351B2 (en) 2001-12-20 2007-08-15 Use of CPG oligodeoxynucleotides to induce angiogenesis
US12/205,756 Continuation-In-Part US8466116B2 (en) 2001-12-20 2008-09-05 Use of CpG oligodeoxynucleotides to induce epithelial cell growth

Publications (2)

Publication Number Publication Date
WO2003054161A2 WO2003054161A2 (en) 2003-07-03
WO2003054161A3 true WO2003054161A3 (en) 2003-10-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/040955 WO2003054161A2 (en) 2001-12-20 2002-12-19 USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS

Country Status (3)

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US (2) US7615227B2 (en)
AU (1) AU2002366710A1 (en)
WO (1) WO2003054161A2 (en)

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