WO2003055382A3 - Verfahren und vorrichtung zur bestimmung eines lichttransportparameters in einer biologischen matrix - Google Patents

Verfahren und vorrichtung zur bestimmung eines lichttransportparameters in einer biologischen matrix Download PDF

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Publication number
WO2003055382A3
WO2003055382A3 PCT/EP2002/013884 EP0213884W WO03055382A3 WO 2003055382 A3 WO2003055382 A3 WO 2003055382A3 EP 0213884 W EP0213884 W EP 0213884W WO 03055382 A3 WO03055382 A3 WO 03055382A3
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WO
WIPO (PCT)
Prior art keywords
light
detection
point
measuring
biological matrix
Prior art date
Application number
PCT/EP2002/013884
Other languages
English (en)
French (fr)
Other versions
WO2003055382A2 (de
Inventor
Uwe Kraemer
Heinz-Michael Hein
Marcus Hermann
Original Assignee
Roche Diagnostics Gmbh
Hoffman La Roche Ag
Uwe Kraemer
Heinz-Michael Hein
Marcus Hermann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh, Hoffman La Roche Ag, Uwe Kraemer, Heinz-Michael Hein, Marcus Hermann filed Critical Roche Diagnostics Gmbh
Priority to DE50212550T priority Critical patent/DE50212550D1/de
Priority to AU2002361024A priority patent/AU2002361024A1/en
Priority to JP2003555961A priority patent/JP4038179B2/ja
Priority to US10/499,109 priority patent/US7315752B2/en
Priority to EP02795119A priority patent/EP1463443B1/de
Publication of WO2003055382A2 publication Critical patent/WO2003055382A2/de
Publication of WO2003055382A3 publication Critical patent/WO2003055382A3/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/043—Arrangements of multiple sensors of the same type in a linear array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence

Abstract

Verfahren zur selektiven Bestimmung des Streuindex µs in einer streuenden biologischen Matrix, insbesondere zum Zwecke der nichtinvasiven Bestimmung der Konzentration von Glucose in der Haut, mit Hilfe von Detektionsmessungen, bei denen jeweils Licht als Primärlicht (9) in die biologische Matrix (5) eingestrahlt wird und ein Intensitätsmesswert von an einem Detektionsort (33-40), der sich bei den Detektionsmessungen in unterschiedlichen Messabständen (ρ) von dem jeweiligen Einstrahlungsort (10) befindet, austretendem Sekundärlicht (12) gemessen wird. Um die Qualität und Selektivität der Bestimmung von µs zu verbessern, wird das Primärlicht mittels eines Kontaktierenden Lichtleitelementes schräg unter einem Winkel zwischen 5° und 85° eingestrahlt, wobei bei mindestens zwei Detektionsmessungen der Messabstand (ρ) zwischen dem jeweiligen Einstrahlungsort (10) und dem jeweiligen Detektionsort (33-40) höchstens der fünffachen mittleren freien Weglänge des in der biologischen Matrix propagierenden Lichts entspricht.
PCT/EP2002/013884 2001-12-22 2002-12-07 Verfahren und vorrichtung zur bestimmung eines lichttransportparameters in einer biologischen matrix WO2003055382A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE50212550T DE50212550D1 (de) 2001-12-22 2002-12-07 Verfahren und vorrichtung zur bestimmung eines lichttransportparameters und eines analyten in einer biologischen matrix
AU2002361024A AU2002361024A1 (en) 2001-12-22 2002-12-07 Method and device for determining a light transport parameter in a biological matrix
JP2003555961A JP4038179B2 (ja) 2001-12-22 2002-12-07 生物学的マトリックス中の光輸送パラメータおよび分析物の決定のための方法および装置
US10/499,109 US7315752B2 (en) 2001-12-22 2002-12-07 Method and device for determining a light transport parameter in a biological matrix
EP02795119A EP1463443B1 (de) 2001-12-22 2002-12-07 Verfahren und vorrichtung zur bestimmung eines lichttransportparameters und eines analyten in einer biologischen matrix

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10163972A DE10163972B4 (de) 2001-12-22 2001-12-22 Verfahren und Vorrichtung zur Bestimmung eines Lichttransportparameters und eines Analyten in einer biologischen Matrix
DE10163972.4 2001-12-22

Publications (2)

Publication Number Publication Date
WO2003055382A2 WO2003055382A2 (de) 2003-07-10
WO2003055382A3 true WO2003055382A3 (de) 2003-11-13

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/013884 WO2003055382A2 (de) 2001-12-22 2002-12-07 Verfahren und vorrichtung zur bestimmung eines lichttransportparameters in einer biologischen matrix

Country Status (7)

Country Link
US (1) US7315752B2 (de)
EP (1) EP1463443B1 (de)
JP (1) JP4038179B2 (de)
AT (1) ATE401823T1 (de)
AU (1) AU2002361024A1 (de)
DE (2) DE10163972B4 (de)
WO (1) WO2003055382A2 (de)

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EP1463443A2 (de) 2004-10-06
AU2002361024A8 (en) 2003-07-15
DE10163972B4 (de) 2005-10-27
AU2002361024A1 (en) 2003-07-15
US7315752B2 (en) 2008-01-01
ATE401823T1 (de) 2008-08-15
WO2003055382A2 (de) 2003-07-10
EP1463443B1 (de) 2008-07-23
JP4038179B2 (ja) 2008-01-23
DE50212550D1 (de) 2008-09-04
DE10163972A1 (de) 2003-07-10
JP2005513491A (ja) 2005-05-12
US20050002031A1 (en) 2005-01-06

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