WO2003055589A3 - Microtiter plate for parallel micro synthesis, especially at high temperatures - Google Patents

Microtiter plate for parallel micro synthesis, especially at high temperatures Download PDF

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Publication number
WO2003055589A3
WO2003055589A3 PCT/EP2002/014763 EP0214763W WO03055589A3 WO 2003055589 A3 WO2003055589 A3 WO 2003055589A3 EP 0214763 W EP0214763 W EP 0214763W WO 03055589 A3 WO03055589 A3 WO 03055589A3
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
high temperatures
microtiter plate
intermediate walls
micro
Prior art date
Application number
PCT/EP2002/014763
Other languages
German (de)
French (fr)
Other versions
WO2003055589A2 (en
Inventor
Jens Albert
Guenter Mayer
Andreas Schober
Alexander Gross
Original Assignee
Inst Physikalische Hochtech Ev
Jens Albert
Guenter Mayer
Andreas Schober
Alexander Gross
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Physikalische Hochtech Ev, Jens Albert, Guenter Mayer, Andreas Schober, Alexander Gross filed Critical Inst Physikalische Hochtech Ev
Publication of WO2003055589A2 publication Critical patent/WO2003055589A2/en
Publication of WO2003055589A3 publication Critical patent/WO2003055589A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50857—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using arrays or bundles of open capillaries for holding samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00331—Details of the reactor vessels
    • B01J2219/00333—Closures attached to the reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

The invention relates to a microtiter plate which can be used in the nano range for simultaneously carrying out a plurality of microsyntheses at high temperatures. Said plate is embodied in such a way that the individual micro chambers of the micro or nano chamber matrix can be sealingly closed and the closure and the opening of the micro chamber is automatic before and after a reaction. According to the invention, the filling substances are disposed in chambers which are opened at the top and at the bottom and separated from each other by intermediate walls and which can be closed by covers. The plate is multi-layered and impervious in at least the chamber area and the thickness of the intermediate walls at the chamber openings is thinner than inside the chamber. Protruding edges are formed between the areas of the intermediate walls of various thicknesses.
PCT/EP2002/014763 2001-12-31 2002-12-27 Microtiter plate for parallel micro synthesis, especially at high temperatures WO2003055589A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10164575 2001-12-31
DE10164575.9 2001-12-31

Publications (2)

Publication Number Publication Date
WO2003055589A2 WO2003055589A2 (en) 2003-07-10
WO2003055589A3 true WO2003055589A3 (en) 2003-11-06

Family

ID=7711206

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/014763 WO2003055589A2 (en) 2001-12-31 2002-12-27 Microtiter plate for parallel micro synthesis, especially at high temperatures

Country Status (1)

Country Link
WO (1) WO2003055589A2 (en)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001559A2 (en) * 1993-07-02 1995-01-12 Evotec Biosystems Gmbh Sample holder and its use
WO1999034920A1 (en) * 1998-01-12 1999-07-15 Massachusetts Institute Of Technology Method and apparatus for performing microassays
US6044981A (en) * 1994-03-07 2000-04-04 The Regents Of The University Of California Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
US6157456A (en) * 1997-03-11 2000-12-05 Hvass; Per Cuvette for spectrophotometrical analysis
WO2001014063A1 (en) * 1999-08-25 2001-03-01 Alphahelix Ab Device and method for handling small volume samples and/or reaction mixtures
WO2001061054A2 (en) * 2000-02-18 2001-08-23 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US20010036674A1 (en) * 2000-02-23 2001-11-01 Indermuhle Pierre F. Chips having elevated sample surfaces
DE10025698A1 (en) * 2000-05-23 2001-11-29 Merck Patent Gmbh Parallel microsynthesis apparatus, contains micro-chamber matrices in frame surround, with base and cover plates carrying sealing plungers
WO2002049763A2 (en) * 2000-12-18 2002-06-27 Institut für Physikalische Hochtechnologie e.V. Device for receiving and discharging liquid substances
WO2002087760A1 (en) * 2001-04-30 2002-11-07 Epr Labautomation Ag Method and device for storing and dosing small quantities of liquid

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001559A2 (en) * 1993-07-02 1995-01-12 Evotec Biosystems Gmbh Sample holder and its use
US6044981A (en) * 1994-03-07 2000-04-04 The Regents Of The University Of California Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
US6157456A (en) * 1997-03-11 2000-12-05 Hvass; Per Cuvette for spectrophotometrical analysis
WO1999034920A1 (en) * 1998-01-12 1999-07-15 Massachusetts Institute Of Technology Method and apparatus for performing microassays
WO2001014063A1 (en) * 1999-08-25 2001-03-01 Alphahelix Ab Device and method for handling small volume samples and/or reaction mixtures
WO2001061054A2 (en) * 2000-02-18 2001-08-23 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US20010036674A1 (en) * 2000-02-23 2001-11-01 Indermuhle Pierre F. Chips having elevated sample surfaces
DE10025698A1 (en) * 2000-05-23 2001-11-29 Merck Patent Gmbh Parallel microsynthesis apparatus, contains micro-chamber matrices in frame surround, with base and cover plates carrying sealing plungers
WO2002049763A2 (en) * 2000-12-18 2002-06-27 Institut für Physikalische Hochtechnologie e.V. Device for receiving and discharging liquid substances
WO2002087760A1 (en) * 2001-04-30 2002-11-07 Epr Labautomation Ag Method and device for storing and dosing small quantities of liquid

Also Published As

Publication number Publication date
WO2003055589A2 (en) 2003-07-10

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