WO2003059274A3 - Vitamin formulation for cardiovascular health - Google Patents

Vitamin formulation for cardiovascular health Download PDF

Info

Publication number
WO2003059274A3
WO2003059274A3 PCT/US2003/001228 US0301228W WO03059274A3 WO 2003059274 A3 WO2003059274 A3 WO 2003059274A3 US 0301228 W US0301228 W US 0301228W WO 03059274 A3 WO03059274 A3 WO 03059274A3
Authority
WO
WIPO (PCT)
Prior art keywords
cardiovascular health
vitamin
composition
high level
vitamin formulation
Prior art date
Application number
PCT/US2003/001228
Other languages
French (fr)
Other versions
WO2003059274A2 (en
Inventor
Atef Boulous
Jatin Desai
Neil Martin
Robert Stillman
Marion Udwin
Original Assignee
Bristol Myers Squibb Co
Atef Boulous
Jatin Desai
Neil Martin
Robert Stillman
Marion Udwin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, Atef Boulous, Jatin Desai, Neil Martin, Robert Stillman, Marion Udwin filed Critical Bristol Myers Squibb Co
Priority to AU2003205159A priority Critical patent/AU2003205159A1/en
Publication of WO2003059274A2 publication Critical patent/WO2003059274A2/en
Publication of WO2003059274A3 publication Critical patent/WO2003059274A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Inorganic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention concerns a composition containing a high level of Vitamin E in encapsulated form, preferably as beadlets or spray dried, and a high level of silicates. The composition is compressible into tablets or caplets that do not leach out Vitamin E into the tablet matrix during compression and/or storage. The composition preferably contains vitamins and minerals in doses optimized for cardiovascular health.
PCT/US2003/001228 2002-01-14 2003-01-14 Vitamin formulation for cardiovascular health WO2003059274A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003205159A AU2003205159A1 (en) 2002-01-14 2003-01-14 Vitamin formulation for cardiovascular health

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/047,583 2002-01-14
US10/047,583 US6914073B2 (en) 1999-03-18 2002-01-14 Vitamin formulation for cardiovascular health

Publications (2)

Publication Number Publication Date
WO2003059274A2 WO2003059274A2 (en) 2003-07-24
WO2003059274A3 true WO2003059274A3 (en) 2004-01-15

Family

ID=21949810

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/001228 WO2003059274A2 (en) 2002-01-14 2003-01-14 Vitamin formulation for cardiovascular health

Country Status (3)

Country Link
US (1) US6914073B2 (en)
AU (1) AU2003205159A1 (en)
WO (1) WO2003059274A2 (en)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060105062A1 (en) * 2004-11-12 2006-05-18 Mccleary Edward L Composition and method for modulating addictive behaviors
US6784351B2 (en) * 2001-06-29 2004-08-31 Ball Horticultural Company Targetes erecta marigolds with altered carotenoid compositions and ratios
US7560123B2 (en) * 2004-08-12 2009-07-14 Everett Laboratories, Inc. Compositions and methods for nutrition supplementation
US20040018248A1 (en) * 2001-11-29 2004-01-29 Adrianne Bendich Composition containing statins and calcium for improved cardiovascular health
US8142799B2 (en) * 2001-12-18 2012-03-27 Tamea Rae Sisco High potency clinical anti-craving treatment and method of use
US8142800B1 (en) * 2001-12-18 2012-03-27 Tamea Rae Sisco Oral high potency clinical anti-craving treatment and method of use
GB0220182D0 (en) * 2002-08-30 2002-10-09 Cardiovascular Res Inst Maastr Organic compounds
US8617617B2 (en) 2002-12-10 2013-12-31 Everett Laboratories, Inc. Methods and kits for co-administration of nutritional supplements
US6814983B2 (en) * 2002-12-10 2004-11-09 Everett Laboratories, Inc. Compositions and methods for nutrition supplementation
US20040253319A1 (en) * 2003-06-11 2004-12-16 Shrirang Netke Pharmaceutical compositions and method for alleviating side-effects of estrogen replacement therapy
US7875291B1 (en) 2003-09-05 2011-01-25 Glu-Pro, Inc. Composition for managing diabetes, obesity, and hyperlipidemia and associated methods
US20050053673A1 (en) * 2003-09-05 2005-03-10 Shrirang Netke Composition and method for facilitating bone healing
US7264813B2 (en) * 2003-09-24 2007-09-04 Nikken Sohonsha Corporation Therapeutic uses of Dunaliella powder
US20050074444A1 (en) * 2003-10-01 2005-04-07 Papas Andreas M. Coenzyme Q10 treatment for cystic fibrosis
DE20320101U1 (en) * 2003-12-23 2004-04-29 Dr. Gerhard Mann Chem.-Pharm. Fabrik Gmbh Micronutrient combination product suitable for a supplementary balanced diet for age-related macular degeneration
US20050191369A1 (en) * 2004-02-26 2005-09-01 Proethic Laboratories, L.L.C. Compositions comprising vitamin E and saw palmetto
US7022350B2 (en) 2004-02-26 2006-04-04 Proethic Pharmaceuticals, Inc. Dietary supplement
US7303771B2 (en) * 2004-03-15 2007-12-04 Stephen Truesdale Carney Alfalfa sprout powder based supplement
PL1732605T3 (en) * 2004-03-29 2019-09-30 Wyeth Llc Multi-vitamin and mineral nutritional supplements
US8968768B2 (en) * 2004-03-29 2015-03-03 Wyeth Llc Phytosterol nutritional supplements
US20050233044A1 (en) * 2004-04-19 2005-10-20 Don Rader Encapsulated organic solution particles
CA2503554A1 (en) * 2004-04-27 2005-10-27 Proethic Laboratories, Llc Dietary supplement
JP2006045491A (en) * 2004-07-01 2006-02-16 Erubu:Kk Functional material, method for producing functional material, functional member and environment modification apparatus using the functional material
US8101587B2 (en) 2004-08-12 2012-01-24 Everett Laboratories, Inc. Kits for nutrition supplementation
US7186421B2 (en) 2004-09-29 2007-03-06 Proethic Pharmaceuticals, Inc. Mineral additives for improved processing of compositions containing vitamin E and saw palmetto
US20060068037A1 (en) * 2004-09-29 2006-03-30 Proethic Laboratories, L.L.C. Admixing process for making compositions containing vitamin E and saw palmetto
JP2008515801A (en) * 2004-10-01 2008-05-15 ザ リサーチ ファウンデーション オブ ステイト ユニヴァーシティ オブ ニューヨーク Morphine and morphine precursor
FR2876028B1 (en) * 2004-10-05 2009-10-16 Axiss France Sas ENCAPSULATION OF PLANT EXTRACTS
US20060153823A1 (en) * 2005-01-13 2006-07-13 Everett Laboratories, Inc. Compositions and methods for nutritional supplementation
US20060153824A1 (en) * 2005-01-13 2006-07-13 Everett Laboratories, Inc. Methods and kits for co-administration of nutritional supplements
WO2006085128A1 (en) * 2005-02-09 2006-08-17 Wockhardt Limited Cardiovascular therapeutic combinations
CN1320925C (en) * 2005-03-30 2007-06-13 淮北市辉克药业有限公司 Long time use compound preparation for treating diabetes
US7901710B2 (en) 2005-08-04 2011-03-08 Vertical Pharmaceuticals, Inc. Nutritional supplement for use under physiologically stressful conditions
US7998500B2 (en) 2005-08-04 2011-08-16 Vertical Pharmaceuticals, Inc. Nutritional supplement for women
US8202546B2 (en) 2005-08-04 2012-06-19 Vertical Pharmaceuticals, Inc. Nutritional supplement for use under physiologically stressful conditions
US8263137B2 (en) 2005-08-04 2012-09-11 Vertical Pharmaceuticals, Inc. Nutritional supplement for women
US7790203B2 (en) * 2005-12-13 2010-09-07 Lowder Tom R Composition and regimen for the treatment of herpes simplex virus, herpes zoster, and herpes genitalia epidermal herpetic lesions
US7202229B1 (en) 2005-12-30 2007-04-10 Alan James Group, Llc. Aspirin formulation for cardiovascular health
US7201929B1 (en) * 2005-12-30 2007-04-10 Alan James Group, Llc. Aspirin formulation for cardiovascular health
US20070160695A1 (en) * 2006-01-09 2007-07-12 Clouatre Dallas L Pharmaceutical preparations for treating hypertension and dyslipidemia with Allium ursinum and Allium sativum
US20080057144A1 (en) * 2006-09-01 2008-03-06 Cathy Beggan Wake up on time dietary supplement and method of use
US8021698B2 (en) * 2006-12-20 2011-09-20 Kemin Foods, L.C. Method of improving cardiovascular health
EP3539560A1 (en) 2007-02-22 2019-09-18 Children's Hospital & Research Center at Oakland Fatty acid formulations and methods of use thereof
US20080254119A1 (en) * 2007-04-16 2008-10-16 Wyeth Imbedded liquid lubricants for tableting
US7964189B1 (en) 2007-09-25 2011-06-21 Argent Development Group, Llc Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women
US9125844B1 (en) 2007-09-25 2015-09-08 Argent Development Group, Llc Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women
US20090118229A1 (en) * 2007-11-07 2009-05-07 Bristol-Myers Squibb Company Carotenoid-containing compositions and methods
US20090118227A1 (en) 2007-11-07 2009-05-07 Bristol-Myers Squibb Company Carotenoid-containing compositions and methods
US20100331286A1 (en) * 2008-02-25 2010-12-30 Ray Chow Combination therapy for treatment of bone and mineral disorders for patients with impaired renal function
US10531681B2 (en) 2008-04-25 2020-01-14 Sensient Colors Llc Heat-triggered colorants and methods of making and using the same
US20090298952A1 (en) * 2008-05-07 2009-12-03 Brimmer Karen S Platable soluble dyes
US8535659B1 (en) 2008-05-27 2013-09-17 Argent Development Group, Llc Nutritional supplements for pregnant women
US8535660B1 (en) 2008-05-27 2013-09-17 Argent Development Group, Llc Nutritional supplements for pregnant women
US9113647B2 (en) 2008-08-29 2015-08-25 Sensient Colors Llc Flavored and edible colored waxes and methods for precision deposition on edible substrates
US9545117B2 (en) * 2009-02-03 2017-01-17 Tropicana Products, Inc. Microencapsulated citrus phytochemicals and application to beverages
US20100196549A1 (en) * 2009-02-03 2010-08-05 Tropicana Products, Inc. Microencapsulated citrus phytochemicals and application to sports drinks
US20100196554A1 (en) * 2009-02-03 2010-08-05 Tropicana Products, Inc. Microencapsulated citrus phytochemicals comprising citrus limonoids and application to beverages
US8197871B2 (en) * 2009-05-13 2012-06-12 L Europa Gary A Composition for headache treatment
US20110142766A1 (en) * 2009-12-16 2011-06-16 Sal Rafanelli Effervescent Multi-Vitamin Formulation and Methods of Use Thereof
US8889157B1 (en) 2010-08-31 2014-11-18 Gary L'Europa Composition for cardiovascular treatment
US8183227B1 (en) 2011-07-07 2012-05-22 Chemo S. A. France Compositions, kits and methods for nutrition supplementation
US8168611B1 (en) 2011-09-29 2012-05-01 Chemo S.A. France Compositions, kits and methods for nutrition supplementation
WO2013185024A1 (en) 2012-06-08 2013-12-12 The Ohio State University Treating burn and scar injury using tocotrienol
AU2013290761A1 (en) * 2012-07-19 2015-02-05 The Ohio State University Method of ameliorating clotting pathologies and related materials and methods
EP2815654A1 (en) * 2013-06-21 2014-12-24 Essential IP BV Composition having a beneficial effect on the cardiovascular system, comprising monacolin K, lycopene and vitamin D3
TWI759260B (en) * 2015-01-02 2022-04-01 美商梅拉洛伊卡公司 Multi-supplement compositions
CN106901378A (en) * 2017-03-10 2017-06-30 深圳奥萨医疗有限公司 A kind of health food suitable for women
WO2022129003A1 (en) * 2020-12-15 2022-06-23 Dsm Ip Assets B.V. Multiparticulate solid oral dosage form comprising statin and vitamin e
WO2022129004A1 (en) * 2020-12-15 2022-06-23 Dsm Ip Assets B.V. Coated statin tablet comprising vitamin e acetate powder

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486435A (en) * 1983-05-16 1984-12-04 Basf Wyandotte Corporation Spray-dried vitamin powders using hydrophobic silica
EP0595005A1 (en) * 1992-09-14 1994-05-04 Vesta Medicines (Proprietary) Limited Pharmaceutical preparations for lowering homocysteine levels, containing vitamin B6, folic acid and vitamin B12
US5925381A (en) * 1994-07-01 1999-07-20 Roche Vitamins Inc. Encapsulation of oleophilic substances and compositions produced thereby
US6030645A (en) * 1997-02-28 2000-02-29 Roche Vitamins Inc. Free-flowing dry particles

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2858215A (en) 1956-07-02 1958-10-28 Barnett Lab Inc Process of preparing vitamin oils in particle form
US3608083A (en) 1968-06-05 1971-09-21 Hoffmann La Roche Vitamin e powder
US4603143A (en) 1983-05-02 1986-07-29 Basf Corporation Free-flowing, high density, fat soluble vitamin powders with improved stability
US4617294A (en) 1985-04-22 1986-10-14 Ppg Industries, Inc. Animal feed supplement
WO1992005780A1 (en) 1990-10-01 1992-04-16 Brigham And Women's Hospital Beta-carotene and vitamin e therapy for inhibition of major vascular events
US5571441A (en) 1994-11-01 1996-11-05 The Procter & Gamble Company Nutrient supplement compositions providing physiologic feedback
ATE262799T1 (en) 1996-01-31 2004-04-15 Univ South Alabama FOOD AND VITAMIN PRODUCTIONS WITH NATURAL ISOMERS OF REDUCED FOLATES
US5948443A (en) 1996-02-23 1999-09-07 Medical Doctor's Research Institute, Inc. Acetylsalicylic acid and micronutrient supplementation for nutritional losses and coronary heart disease

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486435A (en) * 1983-05-16 1984-12-04 Basf Wyandotte Corporation Spray-dried vitamin powders using hydrophobic silica
EP0595005A1 (en) * 1992-09-14 1994-05-04 Vesta Medicines (Proprietary) Limited Pharmaceutical preparations for lowering homocysteine levels, containing vitamin B6, folic acid and vitamin B12
US5925381A (en) * 1994-07-01 1999-07-20 Roche Vitamins Inc. Encapsulation of oleophilic substances and compositions produced thereby
US6030645A (en) * 1997-02-28 2000-02-29 Roche Vitamins Inc. Free-flowing dry particles

Also Published As

Publication number Publication date
US20020172721A1 (en) 2002-11-21
US6914073B2 (en) 2005-07-05
WO2003059274A2 (en) 2003-07-24
AU2003205159A1 (en) 2003-07-30
AU2003205159A8 (en) 2003-07-30

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