WO2003059436A3 - Compositions and methods for promoting myocardial and peripheral angiogenesis - Google Patents

Compositions and methods for promoting myocardial and peripheral angiogenesis Download PDF

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Publication number
WO2003059436A3
WO2003059436A3 PCT/US2002/041484 US0241484W WO03059436A3 WO 2003059436 A3 WO2003059436 A3 WO 2003059436A3 US 0241484 W US0241484 W US 0241484W WO 03059436 A3 WO03059436 A3 WO 03059436A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
promoting myocardial
peripheral angiogenesis
angiogenesis
Prior art date
Application number
PCT/US2002/041484
Other languages
French (fr)
Other versions
WO2003059436A2 (en
Inventor
Rama Akella
John Ranieri
Original Assignee
Ct Pulse Biolog Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Pulse Biolog Inc filed Critical Ct Pulse Biolog Inc
Priority to CA002470503A priority Critical patent/CA2470503A1/en
Priority to AU2002367033A priority patent/AU2002367033B2/en
Priority to JP2003559596A priority patent/JP2005518409A/en
Priority to EP02806521A priority patent/EP1478383A4/en
Publication of WO2003059436A2 publication Critical patent/WO2003059436A2/en
Publication of WO2003059436A3 publication Critical patent/WO2003059436A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu

Abstract

Methods, compositions and devices are disclosed for use in growing new blood vessels to restore or improve blood flow to ischemic tissues and organs of the body. Compositions comprising IGD peptides, particularly GGIGDGG, are able to induce migration in human endothelial cells and promote vessel formation in an in vitro model assay system.
PCT/US2002/041484 2001-12-21 2002-12-23 Compositions and methods for promoting myocardial and peripheral angiogenesis WO2003059436A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002470503A CA2470503A1 (en) 2001-12-21 2002-12-23 Compositions and methods for promoting myocardial and peripheral angiogenesis
AU2002367033A AU2002367033B2 (en) 2001-12-21 2002-12-23 Compositions and methods for promoting myocardial and peripheral angiogenesis
JP2003559596A JP2005518409A (en) 2001-12-21 2002-12-23 Compositions and methods for promoting myocardial and peripheral angiogenesis
EP02806521A EP1478383A4 (en) 2001-12-21 2002-12-23 Compositions and methods for promoting myocardial and peripheral angiogenesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/027,015 US7232802B2 (en) 2001-12-21 2001-12-21 Compositions and methods for promoting myocardial and peripheral angiogenesis
US10/027,015 2001-12-21

Publications (2)

Publication Number Publication Date
WO2003059436A2 WO2003059436A2 (en) 2003-07-24
WO2003059436A3 true WO2003059436A3 (en) 2004-09-23

Family

ID=21835160

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/041484 WO2003059436A2 (en) 2001-12-21 2002-12-23 Compositions and methods for promoting myocardial and peripheral angiogenesis

Country Status (6)

Country Link
US (2) US7232802B2 (en)
EP (1) EP1478383A4 (en)
JP (1) JP2005518409A (en)
AU (1) AU2002367033B2 (en)
CA (1) CA2470503A1 (en)
WO (1) WO2003059436A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69714035T2 (en) 1997-08-14 2003-03-06 Sulzer Innotec Ag Composition and device for repairing cartilage tissue in vivo consisting of nanocapsules with osteoinductive and / or chondroinductive factors
US7094258B2 (en) 1999-08-18 2006-08-22 Intrinsic Therapeutics, Inc. Methods of reinforcing an annulus fibrosis
US7717961B2 (en) 1999-08-18 2010-05-18 Intrinsic Therapeutics, Inc. Apparatus delivery in an intervertebral disc
JP4247519B2 (en) 1999-08-18 2009-04-02 イントリンジック セラピューティックス インコーポレイテッド Apparatus and method for nucleus augmentation and retention
US8323341B2 (en) 2007-09-07 2012-12-04 Intrinsic Therapeutics, Inc. Impaction grafting for vertebral fusion
US7998213B2 (en) 1999-08-18 2011-08-16 Intrinsic Therapeutics, Inc. Intervertebral disc herniation repair
US7972337B2 (en) 2005-12-28 2011-07-05 Intrinsic Therapeutics, Inc. Devices and methods for bone anchoring
EP1624832A4 (en) 1999-08-18 2008-12-24 Intrinsic Therapeutics Inc Devices and method for augmenting a vertebral disc nucleus
JP2007151608A (en) * 2005-11-30 2007-06-21 Med Solution Kk Apparatus and program for quantitatively evaluating complexity of shape and travel of organ
US20080159604A1 (en) * 2005-12-30 2008-07-03 Allan Wang Method and system for imaging to identify vascularization
US20110196492A1 (en) 2007-09-07 2011-08-11 Intrinsic Therapeutics, Inc. Bone anchoring systems
GB0813659D0 (en) 2008-07-25 2008-09-03 Smith & Nephew Fracture putty
US8349325B2 (en) 2008-12-23 2013-01-08 Abbott Laboratories Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making
JP5664992B2 (en) * 2009-08-26 2015-02-04 国立大学法人名古屋大学 Cell specific peptides and uses thereof
KR101335203B1 (en) * 2010-03-26 2013-11-29 숙명여자대학교산학협력단 Peptides for Promotion of Angiogenesis and the use thereof
JP5808631B2 (en) 2011-09-29 2015-11-10 富士フイルム株式会社 Angiogenic scaffold and method for producing blood vessel for regenerative medicine

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002674A1 (en) * 1997-07-08 1999-01-21 University Of Dundee Peptides containing the motif igd and their use as cell migration modulators
US20020040004A1 (en) * 1998-10-16 2002-04-04 Benedict James J. Method of promoting natural bypass
US6468960B1 (en) * 1999-04-23 2002-10-22 Prolifia, Inc. Therapeutic compositions and methods for enhancing angiogenesis

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5831210B2 (en) 1973-04-09 1983-07-05 武田薬品工業株式会社 antennae
US4172128A (en) 1975-03-26 1979-10-23 Erhard Thiele Process of degrading and regenerating bone and tooth material and products
US4619989A (en) 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
US4455256A (en) 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4761471A (en) 1980-08-04 1988-08-02 The Regents Of The University Of California Bone morphogenetic protein composition
JPS57144756A (en) 1981-03-04 1982-09-07 Koken Kk Impermeable laminated film
US5705477A (en) * 1982-09-24 1998-01-06 The United States Of America As Represented By The Department Of Health And Human Services Compositions of transforming growth factor β(TGF-β) which promotes wound healing and methods for their use
US5656587A (en) * 1982-09-24 1997-08-12 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Promotion of cell proliferation by use of transforming growth factor beta (TGF-β)
US4529590A (en) 1982-12-27 1985-07-16 Leveen Robert F Production of angiogenetic factor
US5328695A (en) * 1983-03-22 1994-07-12 Massachusetts Institute Of Technology Muscle morphogenic protein and use thereof
US4801299A (en) 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US4596574A (en) 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
US4620327A (en) 1984-07-05 1986-11-04 Caplan Arnold I Process of adapting soluble bone protein for use in stimulating osteoinduction
US4699788A (en) * 1984-08-20 1987-10-13 Trustees Of Boston University Angiogenic factor methods of extraction and method for producing angiogenesis
JPH0678460B2 (en) 1985-05-01 1994-10-05 株式会社バイオマテリアル・ユニバース Porous transparent polyvinyl alcohol gel
US4678470A (en) 1985-05-29 1987-07-07 American Hospital Supply Corporation Bone-grafting material
US4774227A (en) 1986-02-14 1988-09-27 Collagen Corporation Collagen compositions for bone repair containing autogeneic marrow
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5459047A (en) * 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
ZA874681B (en) * 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US5631142A (en) * 1986-07-01 1997-05-20 Genetics Institute, Inc. Compositions comprising bone morphogenetic protein-2 (BMP-2)
US5543394A (en) * 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US6432919B1 (en) * 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
US4902296A (en) 1986-10-29 1990-02-20 The University Of Virginia Alumni Patents Foundation Use of demineralized bone matrix in the repair of segmental defects
US4743259A (en) 1986-10-29 1988-05-10 The University Of Virginia Alumni Patents Foundation Use of demineralized bone matrix in the repair of segmental defects
US4834757A (en) 1987-01-22 1989-05-30 Brantigan John W Prosthetic implant
US4952404A (en) 1987-06-19 1990-08-28 President And Fellows Of Harvard College Promotion of healing of meniscal tissue
US5258043A (en) 1987-07-20 1993-11-02 Regen Corporation Method for making a prosthetic intervertebral disc
US5681353A (en) 1987-07-20 1997-10-28 Regen Biologics, Inc. Meniscal augmentation device
US5108438A (en) 1989-03-02 1992-04-28 Regen Corporation Prosthetic intervertebral disc
US4772287A (en) 1987-08-20 1988-09-20 Cedar Surgical, Inc. Prosthetic disc and method of implanting
US4863732A (en) 1987-12-16 1989-09-05 Collagen Corporation Injectable composition for inductive bone repair
US4895838A (en) * 1988-03-09 1990-01-23 Trustees Of Boston University Method for provoking angiogenesis by administration of angiogenically active oligosaccharides
US4900673A (en) * 1988-03-28 1990-02-13 President And Fellows Of Harvard College Mutant human angiogenin (angiogenesis factor with superior angiogenin activity) genes therefor and methods of expression
US5219576A (en) * 1988-06-30 1993-06-15 Collagen Corporation Collagen wound healing matrices and process for their production
US4950483A (en) * 1988-06-30 1990-08-21 Collagen Corporation Collagen wound healing matrices and process for their production
US5545229A (en) 1988-08-18 1996-08-13 University Of Medicine And Dentistry Of Nj Functional and biocompatible intervertebral disc spacer containing elastomeric material of varying hardness
US5936035A (en) 1988-11-21 1999-08-10 Cohesion Technologies, Inc. Biocompatible adhesive compositions
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5356630A (en) 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US5015255A (en) 1989-05-10 1991-05-14 Spine-Tech, Inc. Spinal stabilization method
US5100422A (en) 1989-05-26 1992-03-31 Impra, Inc. Blood vessel patch
CA2022480C (en) 1989-08-02 2001-02-27 Gerald L. Mechanic Process for cross-linking collagenous materials and resulting product
GB8927546D0 (en) 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
FR2659226B1 (en) 1990-03-07 1992-05-29 Jbs Sa PROSTHESIS FOR INTERVERTEBRAL DISCS AND ITS IMPLEMENTATION INSTRUMENTS.
US5342394A (en) 1990-05-16 1994-08-30 Olympus Optical Co., Ltd. Apparatus for blocking a vein branch and method of blocking a vein branch
DE69111021T2 (en) 1990-10-31 1996-01-04 Gendler El Flexible membrane made from organic bone matrix for repairing and restoring bones.
AU651421B2 (en) 1990-11-30 1994-07-21 Celtrix Pharmaceuticals, Inc. Use of a bone morphogenetic protein in synergistic combination with TGF-beta for bone repair
KR100204400B1 (en) * 1990-12-21 1999-06-15 로날드 지. 더프 Angiogenic peptides
US5047055A (en) 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
US5192326A (en) 1990-12-21 1993-03-09 Pfizer Hospital Products Group, Inc. Hydrogel bead intervertebral disc nucleus
US5206023A (en) 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5171278A (en) 1991-02-22 1992-12-15 Madhavan Pisharodi Middle expandable intervertebral disk implants
US5390683A (en) 1991-02-22 1995-02-21 Pisharodi; Madhavan Spinal implantation methods utilizing a middle expandable implant
US5972884A (en) * 1991-03-11 1999-10-26 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US5290763A (en) * 1991-04-22 1994-03-01 Intermedics Orthopedics/Denver, Inc. Osteoinductive protein mixtures and purification processes
US5563124A (en) 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
EP0516901A1 (en) 1991-06-06 1992-12-09 Richard L. Lindstrom Method and apparatus of a serumfree medical solution
KR100255415B1 (en) * 1991-06-25 2000-05-01 브루스 엠. 에이센 Bone morphogenetic protein-9 compositions
US5741429A (en) 1991-09-05 1998-04-21 Cardia Catheter Company Flexible tubular device for use in medical applications
CA2117088A1 (en) 1991-09-05 1993-03-18 David R. Holmes Flexible tubular device for use in medical applications
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5304194A (en) 1991-10-02 1994-04-19 Target Therapeutics Vasoocclusion coil with attached fibrous element(s)
ATE238417T1 (en) * 1991-11-04 2003-05-15 Inst Genetics Llc RECOMBINANT BONE MORPHOGENETIC PROTEIN HETERODIMERS, COMPOSITIONS AND METHODS OF USE
US5147374A (en) 1991-12-05 1992-09-15 Alfredo Fernandez Prosthetic mesh patch for hernia repair
US6120760A (en) * 1992-02-12 2000-09-19 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Growth/differentiation factors of the TGF-β family
DE4210334A1 (en) 1992-03-30 1993-10-07 Stoess & Co Gelatine Biodegradable, water-resistant polymer material
US5413571A (en) 1992-07-16 1995-05-09 Sherwood Medical Company Device for sealing hemostatic incisions
JPH0648955A (en) * 1992-07-29 1994-02-22 Morinaga Milk Ind Co Ltd Activator for digestive tract cell
US5800537A (en) 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
US5318957A (en) * 1992-09-02 1994-06-07 The United States Of America As Represented By The Department Of Health And Human Services Method of stimulating angiogenesis
US5437288A (en) 1992-09-04 1995-08-01 Mayo Foundation For Medical Education And Research Flexible catheter guidewire
US5478739A (en) 1992-10-23 1995-12-26 Advanced Tissue Sciences, Inc. Three-dimensional stromal cell and tissue culture system
US5616490A (en) * 1992-12-07 1997-04-01 Ribozyme Pharmaceuticals, Inc. Ribozymes targeted to TNF-α RNA
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
US5637480A (en) * 1993-05-12 1997-06-10 Genetics Institute, Inc. DNA molecules encoding bone morphogenetic protein-10
IL110589A0 (en) * 1993-08-10 1994-11-11 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF- beta family
US5425772A (en) 1993-09-20 1995-06-20 Brantigan; John W. Prosthetic implant for intervertebral spinal fusion
US5370660A (en) 1993-11-01 1994-12-06 Cordis Corporation Apparatus and method for delivering a vessel plug into the body of a patient
US5514180A (en) 1994-01-14 1996-05-07 Heggeness; Michael H. Prosthetic intervertebral devices
US5556429A (en) 1994-05-06 1996-09-17 Advanced Bio Surfaces, Inc. Joint resurfacing system
US5681310A (en) 1994-07-20 1997-10-28 Yuan; Hansen A. Vertebral auxiliary fixation device having holding capability
US5707962A (en) 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
US5562736A (en) 1994-10-17 1996-10-08 Raymedica, Inc. Method for surgical implantation of a prosthetic spinal disc nucleus
US5824093A (en) 1994-10-17 1998-10-20 Raymedica, Inc. Prosthetic spinal disc nucleus
US5674296A (en) 1994-11-14 1997-10-07 Spinal Dynamics Corporation Human spinal disc prosthesis
US5846770A (en) * 1994-11-22 1998-12-08 Genetics Institute, Inc. DNA molecules encoding human chordin
US5677276A (en) * 1994-12-23 1997-10-14 La Jolla Cancer Research Foundation Immobilization of peptides to hyaluronate
US5733337A (en) 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
US5635372A (en) 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
WO1996041818A1 (en) * 1995-06-09 1996-12-27 Drohan William N Chitin hydrogels, methods of their production and use
EP0768332B1 (en) 1995-10-11 2001-03-28 Sulzer Markets and Technology AG Process for photooxidative treatment of collagen-containing tissues
US6048964A (en) * 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
PT1704878E (en) * 1995-12-18 2013-07-17 Angiodevice Internat Gmbh Crosslinked polymer compositions and methods for their use
US5645597A (en) 1995-12-29 1997-07-08 Krapiva; Pavel I. Disc replacement method and apparatus
US5800550A (en) 1996-03-13 1998-09-01 Sertich; Mario M. Interbody fusion cage
US6498142B1 (en) 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
US5981489A (en) * 1996-07-18 1999-11-09 Alza Corporation Non-aqueous protic peptide formulations
US5716416A (en) 1996-09-10 1998-02-10 Lin; Chih-I Artificial intervertebral disk and method for implanting the same
US5965403A (en) * 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
US5928940A (en) * 1996-09-24 1999-07-27 Creative Biomolecules, Inc. Morphogen-responsive signal transducer and methods of use thereof
US5827328A (en) 1996-11-22 1998-10-27 Buttermann; Glenn R. Intervertebral prosthetic device
US5776142A (en) 1996-12-19 1998-07-07 Medtronic, Inc. Controllable stent delivery system and method
US5815904A (en) 1997-03-13 1998-10-06 Intratherapeutics, Inc. Method for making a stent
US5800549A (en) 1997-04-30 1998-09-01 Howmedica Inc. Method and apparatus for injecting an elastic spinal implant
CA2314821A1 (en) 1997-12-17 1999-06-24 Creative Biomolecules, Inc. Methods for maintaining or restoring tissue-appropriate phenotype of soft tissue cells
US6211157B1 (en) 1998-05-01 2001-04-03 Sulzer Biologics, Inc. Protein mixtures to induce therapeutic angiogenesis
US6992066B2 (en) * 1998-10-16 2006-01-31 Zimmer Orthobiologics, Inc. Povidone-containing carriers for polypeptide growth factors
AU3897200A (en) 1999-03-18 2000-10-04 Hope Heart Institute, The Endothelial cell stimulation by a complex of fibronectin and vascular endothelial growth factor
US20030104977A1 (en) * 2000-03-31 2003-06-05 Ugo Ripamonti Methods for inducing angiogenesis using morphogenic proteins and stimulatory factors
US7081240B1 (en) 2000-06-28 2006-07-25 Zimmer Orthobiologics, Inc. Protein mixtures for wound healing
US20020025340A1 (en) * 2000-08-30 2002-02-28 Dyer Wallace K. Methods and compositions for tissue augmentation
US20020173453A1 (en) 2000-12-15 2002-11-21 Rama Akella Method of treating renal injury

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002674A1 (en) * 1997-07-08 1999-01-21 University Of Dundee Peptides containing the motif igd and their use as cell migration modulators
US20020040004A1 (en) * 1998-10-16 2002-04-04 Benedict James J. Method of promoting natural bypass
US6468960B1 (en) * 1999-04-23 2002-10-22 Prolifia, Inc. Therapeutic compositions and methods for enhancing angiogenesis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHERNOUSOV M. ET AL: "Role of the I-9 and III-1 modules of fibronectin in formation of an extracellular fibronectin matrix", J. BIOL. CHEM., vol. 266, no. 17, 15 June 1991 (1991-06-15), pages 10851 - 10858, XP002197279 *
See also references of EP1478383A4 *

Also Published As

Publication number Publication date
JP2005518409A (en) 2005-06-23
US7232802B2 (en) 2007-06-19
US7579322B2 (en) 2009-08-25
EP1478383A4 (en) 2006-05-10
US20070287671A1 (en) 2007-12-13
AU2002367033B2 (en) 2008-04-17
CA2470503A1 (en) 2003-07-24
US20050143312A1 (en) 2005-06-30
EP1478383A2 (en) 2004-11-24
WO2003059436A2 (en) 2003-07-24
AU2002367033A1 (en) 2003-07-30

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