WO2003059441B1 - Variation of neural-stimulation parameters - Google Patents

Variation of neural-stimulation parameters

Info

Publication number
WO2003059441B1
WO2003059441B1 PCT/US2003/000461 US0300461W WO03059441B1 WO 2003059441 B1 WO2003059441 B1 WO 2003059441B1 US 0300461 W US0300461 W US 0300461W WO 03059441 B1 WO03059441 B1 WO 03059441B1
Authority
WO
WIPO (PCT)
Prior art keywords
stimulation
neural
parameter
randomly
electrode
Prior art date
Application number
PCT/US2003/000461
Other languages
French (fr)
Other versions
WO2003059441A1 (en
Inventor
Paul H Stypulkowski
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc filed Critical Medtronic Inc
Priority to EP03702038A priority Critical patent/EP1467795B1/en
Priority to AU2003202924A priority patent/AU2003202924A1/en
Priority to DE60321130T priority patent/DE60321130D1/en
Publication of WO2003059441A1 publication Critical patent/WO2003059441A1/en
Publication of WO2003059441B1 publication Critical patent/WO2003059441B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071—Pain

Abstract

Techniques for varying stimulus parameters used in neural stimulation to improve therapy efficacy, minimize energy consumption, minimize undesired side effects, and minimize loss of therapeutic effectiveness due to physiologic tolerance to stimulation. Neural stimulation is provided having a stimulation amplitude, a stimulation frequency, a stimulation pulse duration, an electrode-firing pattern, and a set of electrode-firing-polarity conditions. At least one of the stimulation parameters is pseudo-randomly varied. A second stimulation parameter is changed based upon having pseudo-randomly varied the first stimulation parameter and based upon a predetermined relationship specifying how changes in the first parameter affect desirable values for the second parameter.

Claims

AMENDED CLAIMS[received by the International Bureau on 08 July 2003 (08.07.03); original claims 1-12, 19-23 cancelled; original claims 13-18 renumbered as claims 1-6; new claims 7-13 added (4 pages)]
1. A neural-stimulation device (10) comprising: means for providing neural stimulation having a plurality of stimulation parameters including a stimulation amplitude, a stimulation frequency, a stimulation pulse duration, an electrode-firing pattern, and a set of one or more electrode- polarity-firing conditions; means for randomly or pseudo-randomly varying at least a first of the stimulation parameters; and means for changing a value of a second stimulation parameter based upon having varied the first stimulation parameter and based upon a predetermined relationship that specifies how changes in the first parameter affect desirable values for the second parameter.
2. The neural-stimulation device (10) of claim 1 in which the means for randomly or pseudo-randomly varying at least a first of the stimulation parameters includes means for pseudo-randomly varying at least the first of the stimulation parameters.
3. The neural-stimulation device (10) of claim 2 in which the means for pseudo-randomly varying at least the first of the stimulation parameters varies at least the first stimulation parameter within a predetermined range.
4. The neural-stimulation device (10) of claim 2 or 3 in which: the means for providing neural stimulation includes an implantable pulse generator and a lead having at least one electrode operatively coupled with the implantable pulse generator; the means for randomly or pseudo-randomly varying at least a first of the stimulation parameters is implemented in software operatively associated with the implantable pulse generator; and 18
the means for changing a value of a second stimulation parameter based upon having varied the first stimulation parameter and based upon a predetermined relationship that specifies how changes in the first parameter affect desirable values for the second parameter parameters is implemented in software operatively associated with the implantable pulse generator.
5. The neural-stimulation device (10) any of claims 1-4 in which the means for providing neural stimulation includes a pulse generator and a lead having at least one electrode operatively coupled with the pulse generator.
6. A neural-stimulation system comprising: at least one neural-stimulation lead (22A), wherein at least one of the leads (22A) has at least one neural-stimulation electrode; and a neural-stimulation device (10) according to any of claims 1-5.
7. The neural-stimulation device (10) or system of any of claims 1-6, wherein the predetermined relationship is substantially similar to a strength-duration curve for neural excitation.
8. The neural-stimulation device (10) or system of any of claims 1-7, in which the means for randomly or pseudo-randomly varying at least a first of the stimulation parameters includes: means for varying the first stimulation parameter to produce a neuron-firing pattern having a plurality of different interspike intervals measured either over an interspike-measurement duration or over a plurality of spikes.
9. The neural-stimulation device (10) or system of claim 8, wherein the means for varying the first stimulation parameter to produce a neuron-firing pattern having a plurality of different interspike intervals comprises: means for varying the first stimulation parameter to produce a plurality of neuron-firing patterns selected from the group consisting of: a 19
substantially-normal-distribution neural-firing pattern, a skew-left- distribution neural-firing pattern, a skew-right-distribution neural-firing pattern, and a bimodal-bursting-distribution neural-firing pattern.
10. The neural-stimulationdevice (10) or system of any of claims 1-9, wherein at least one of the one or more electrode-polarity-firing conditions is selected from the group consisting of: anode, cathode, and off.
11. The neural-stimulation device ( 10) or system of any of claims 1 - 10 in which the means for randomly or pseudo-randomly varying at least a first of the stimulation parameters is adapted to vary at least a first of the stimulation parameters sufficiently to avoid development of physiological tolerance to the neural-stimulation.
12. The neural-stimulation device (10) or system of any of claims 1-11 in which: the means for randomly or pseudo-randomly varying at least a first of the stimulation parameters is adapted to vary at least a first stimulation parameter selected from the group consisting of stimulation amplitude, a stimulation pulse duration, an electrode-firing pattern, and a set of one or more electrode- polarity-firing conditions; and the means for changing a value of a second stimulation parameter based upon having randomly or pseudo-randomly varied the first stimulation parameter and based upon a predetermined relationship that specifies how changes in the first parameter affect desirable values for the second parameter is adapted to vary a second stimulation parameter selected from the group consisting of stimulation amplitude, a stimulation frequency, a stimulation pulse duration, an electrode- firing pattern, and a set of one or more electrode-polarity-firing conditions.
13. The neural-stimulation device (10) or system of any of claims 1-11 in which: 20
the means for randomly or pseudo-randomly varying at least a first of the stimulation parameters is adapted to vary at least a first stimulation parameter selected from the group consisting of stimulation amplitude and stimulation pulse duration; and the means for changing a value of a second stimulation parameter based upon having randomly or pseudo-randomly varied the first stimulation parameter and based upon a predetermined relationship that specifies how changes in the first parameter affect desirable values for the second parameter is adapted to vary a second stimulation parameter selected from the group consisting of stimulation amplitude, a stimulation frequency, a stimulation pulse duration, an electrode- firing pattern, and a set of one or more electrode-polarity-firing conditions.
PCT/US2003/000461 2002-01-11 2003-01-08 Variation of neural-stimulation parameters WO2003059441A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP03702038A EP1467795B1 (en) 2002-01-11 2003-01-08 Variation of neural-stimulation parameters
AU2003202924A AU2003202924A1 (en) 2002-01-11 2003-01-08 Variation of neural-stimulation parameters
DE60321130T DE60321130D1 (en) 2002-01-11 2003-01-08 VARIATION OF PARAMETERS FOR NEUROSTIMULATION

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/044,405 2002-01-11
US10/044,405 US7050856B2 (en) 2002-01-11 2002-01-11 Variation of neural-stimulation parameters

Publications (2)

Publication Number Publication Date
WO2003059441A1 WO2003059441A1 (en) 2003-07-24
WO2003059441B1 true WO2003059441B1 (en) 2003-08-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/000461 WO2003059441A1 (en) 2002-01-11 2003-01-08 Variation of neural-stimulation parameters

Country Status (5)

Country Link
US (3) US7050856B2 (en)
EP (1) EP1467795B1 (en)
AU (1) AU2003202924A1 (en)
DE (1) DE60321130D1 (en)
WO (1) WO2003059441A1 (en)

Families Citing this family (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7756584B2 (en) 2000-07-13 2010-07-13 Advanced Neuromodulation Systems, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7305268B2 (en) * 2000-07-13 2007-12-04 Northstar Neurscience, Inc. Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators
US7831305B2 (en) 2001-10-15 2010-11-09 Advanced Neuromodulation Systems, Inc. Neural stimulation system and method responsive to collateral neural activity
US7236831B2 (en) * 2000-07-13 2007-06-26 Northstar Neuroscience, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7616996B2 (en) * 2005-09-01 2009-11-10 Intrapace, Inc. Randomized stimulation of a gastrointestinal organ
US7050856B2 (en) * 2002-01-11 2006-05-23 Medtronic, Inc. Variation of neural-stimulation parameters
US20080077192A1 (en) 2002-05-03 2008-03-27 Afferent Corporation System and method for neuro-stimulation
US20050075680A1 (en) 2003-04-18 2005-04-07 Lowry David Warren Methods and systems for intracranial neurostimulation and/or sensing
CA2508800A1 (en) 2002-12-11 2004-06-24 Proteus Biomedical, Inc. Method and system for monitoring and treating hemodynamic parameters
EP1585575A4 (en) * 2003-01-24 2011-02-09 Proteus Biomedical Inc Methods and apparatus for enhancing cardiac pacing
US7613515B2 (en) * 2003-02-03 2009-11-03 Enteromedics Inc. High frequency vagal blockage therapy
US20040172084A1 (en) 2003-02-03 2004-09-02 Knudson Mark B. Method and apparatus for treatment of gastro-esophageal reflux disease (GERD)
US7844338B2 (en) 2003-02-03 2010-11-30 Enteromedics Inc. High frequency obesity treatment
US7444183B2 (en) * 2003-02-03 2008-10-28 Enteromedics, Inc. Intraluminal electrode apparatus and method
JP2007501067A (en) 2003-08-01 2007-01-25 ノーススター ニューロサイエンス インコーポレイテッド Apparatus and method for applying neural stimulation to patient
EP1694403A2 (en) * 2003-11-20 2006-08-30 Advanced Neuromodulation Systems, Inc. Electrical stimulation system, lead, and method providing reduced neuroplasticity effects
WO2005051479A2 (en) * 2003-11-20 2005-06-09 Advanced Neuromodulation Systems, Inc. Electrical stimulation system and method for treating tinnitus
US20060247693A1 (en) 2005-04-28 2006-11-02 Yanting Dong Non-captured intrinsic discrimination in cardiac pacing response classification
US7774064B2 (en) 2003-12-12 2010-08-10 Cardiac Pacemakers, Inc. Cardiac response classification using retriggerable classification windows
US20060004422A1 (en) * 2004-03-11 2006-01-05 Dirk De Ridder Electrical stimulation system and method for stimulating tissue in the brain to treat a neurological condition
JP2008506464A (en) 2004-07-15 2008-03-06 ノーススター ニューロサイエンス インコーポレイテッド System and method for enhancing or influencing neural stimulation efficiency and / or efficacy
US8014870B2 (en) * 2004-08-11 2011-09-06 Seidman Michael D Method and apparatus for the treatment of tinnitus
EP1799101A4 (en) * 2004-09-02 2008-11-19 Proteus Biomedical Inc Methods and apparatus for tissue activation and monitoring
US8239029B2 (en) * 2004-10-21 2012-08-07 Advanced Neuromodulation Systems, Inc. Stimulation of the amygdalohippocampal complex to treat neurological conditions
WO2006047264A1 (en) * 2004-10-21 2006-05-04 Advanced Neuromodulation Systems, Inc. Peripheral nerve stimulation to treat auditory dysfunction
US7565200B2 (en) * 2004-11-12 2009-07-21 Advanced Neuromodulation Systems, Inc. Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects
US20060106430A1 (en) * 2004-11-12 2006-05-18 Brad Fowler Electrode configurations for reducing invasiveness and/or enhancing neural stimulation efficacy, and associated methods
US7366571B2 (en) * 2004-12-10 2008-04-29 Cyberonics, Inc. Neurostimulator with activation based on changes in body temperature
DE102004060514A1 (en) * 2004-12-16 2006-06-29 Forschungszentrum Jülich GmbH Method and apparatus for desynchronizing neuronal brain activity, control, and methods for treating neuronal and / or psychiatric disorders
US8788044B2 (en) 2005-01-21 2014-07-22 Michael Sasha John Systems and methods for tissue stimulation in medical treatment
US8825166B2 (en) * 2005-01-21 2014-09-02 John Sasha John Multiple-symptom medical treatment with roving-based neurostimulation
US8600521B2 (en) 2005-01-27 2013-12-03 Cyberonics, Inc. Implantable medical device having multiple electrode/sensor capability and stimulation based on sensed intrinsic activity
US8260426B2 (en) 2008-01-25 2012-09-04 Cyberonics, Inc. Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device
US8565867B2 (en) 2005-01-28 2013-10-22 Cyberonics, Inc. Changeable electrode polarity stimulation by an implantable medical device
US7561918B2 (en) * 2005-01-28 2009-07-14 Cyberonics, Inc. Autocapture in a neurostimulator
US20060173493A1 (en) * 2005-01-28 2006-08-03 Cyberonics, Inc. Multi-phasic signal for stimulation by an implantable device
US7454245B2 (en) * 2005-01-28 2008-11-18 Cyberonics, Inc. Trained and adaptive response in a neurostimulator
US9314633B2 (en) 2008-01-25 2016-04-19 Cyberonics, Inc. Contingent cardio-protection for epilepsy patients
US20060229687A1 (en) * 2005-04-11 2006-10-12 Medtronic, Inc. Shifting between electrode combinations in electrical stimulation device
US7519431B2 (en) 2005-04-11 2009-04-14 Medtronic, Inc. Shifting between electrode combinations in electrical stimulation device
US7392086B2 (en) 2005-04-26 2008-06-24 Cardiac Pacemakers, Inc. Implantable cardiac device and method for reduced phrenic nerve stimulation
US8660647B2 (en) * 2005-07-28 2014-02-25 Cyberonics, Inc. Stimulating cranial nerve to treat pulmonary disorder
US7856273B2 (en) 2005-07-28 2010-12-21 Cyberonics, Inc. Autonomic nerve stimulation to treat a gastrointestinal disorder
US7706874B2 (en) 2005-07-28 2010-04-27 Cyberonics, Inc. Stimulating cranial nerve to treat disorders associated with the thyroid gland
US20070027486A1 (en) * 2005-07-29 2007-02-01 Cyberonics, Inc. Medical devices for enhancing intrinsic neural activity
US7532935B2 (en) * 2005-07-29 2009-05-12 Cyberonics, Inc. Selective neurostimulation for treating mood disorders
US7499752B2 (en) 2005-07-29 2009-03-03 Cyberonics, Inc. Selective nerve stimulation for the treatment of eating disorders
US20070027499A1 (en) * 2005-07-29 2007-02-01 Cyberonics, Inc. Neurostimulation device for treating mood disorders
US7672727B2 (en) * 2005-08-17 2010-03-02 Enteromedics Inc. Neural electrode treatment
US7822486B2 (en) 2005-08-17 2010-10-26 Enteromedics Inc. Custom sized neural electrodes
US8428731B2 (en) * 2005-10-27 2013-04-23 Cyberonics, Inc. Sequenced therapy protocols for an implantable medical device
US20070100377A1 (en) * 2005-10-28 2007-05-03 Cyberonics, Inc. Providing multiple signal modes for a medical device
US7957796B2 (en) 2005-10-28 2011-06-07 Cyberonics, Inc. Using physiological sensor data with an implantable medical device
US7555344B2 (en) * 2005-10-28 2009-06-30 Cyberonics, Inc. Selective neurostimulation for treating epilepsy
US8694118B2 (en) * 2005-10-28 2014-04-08 Cyberonics, Inc. Variable output ramping for an implantable medical device
US7996079B2 (en) 2006-01-24 2011-08-09 Cyberonics, Inc. Input response override for an implantable medical device
US7801601B2 (en) 2006-01-27 2010-09-21 Cyberonics, Inc. Controlling neuromodulation using stimulus modalities
WO2007115118A1 (en) 2006-03-29 2007-10-11 Catholic Healthcare West Vagus nerve stimulation method
US7715920B2 (en) * 2006-04-28 2010-05-11 Medtronic, Inc. Tree-based electrical stimulator programming
US8306624B2 (en) 2006-04-28 2012-11-06 Medtronic, Inc. Patient-individualized efficacy rating
US8380300B2 (en) * 2006-04-28 2013-02-19 Medtronic, Inc. Efficacy visualization
US8355789B2 (en) * 2006-04-28 2013-01-15 Medtronic, Inc. Method and apparatus providing asynchronous neural stimulation
US7869885B2 (en) 2006-04-28 2011-01-11 Cyberonics, Inc Threshold optimization for tissue stimulation therapy
US7962220B2 (en) 2006-04-28 2011-06-14 Cyberonics, Inc. Compensation reduction in tissue stimulation therapy
US8014866B2 (en) 2006-07-13 2011-09-06 Cardiac Pacemakers, Inc. Variable voltage compliance for current output generator
US8103341B2 (en) 2006-08-25 2012-01-24 Cardiac Pacemakers, Inc. System for abating neural stimulation side effects
US8209013B2 (en) * 2006-09-14 2012-06-26 Cardiac Pacemakers, Inc. Therapeutic electrical stimulation that avoids undesirable activation
US7869867B2 (en) 2006-10-27 2011-01-11 Cyberonics, Inc. Implantable neurostimulator with refractory stimulation
US8224453B2 (en) 2007-03-15 2012-07-17 Advanced Neuromodulation Systems, Inc. Spinal cord stimulation to treat pain
US8364273B2 (en) * 2007-04-24 2013-01-29 Dirk De Ridder Combination of tonic and burst stimulations to treat neurological disorders
US7974701B2 (en) 2007-04-27 2011-07-05 Cyberonics, Inc. Dosing limitation for an implantable medical device
US20080281365A1 (en) * 2007-05-09 2008-11-13 Tweden Katherine S Neural signal duty cycle
US9987488B1 (en) 2007-06-27 2018-06-05 Respicardia, Inc. Detecting and treating disordered breathing
US8694105B2 (en) * 2007-07-10 2014-04-08 Sapiens Steering Brain Stimulation B.V. Neurostimulation system having a controller for controlling the supply of electrical pulses
US8265736B2 (en) 2007-08-07 2012-09-11 Cardiac Pacemakers, Inc. Method and apparatus to perform electrode combination selection
US9037239B2 (en) 2007-08-07 2015-05-19 Cardiac Pacemakers, Inc. Method and apparatus to perform electrode combination selection
US10076655B2 (en) * 2007-09-21 2018-09-18 Koninklijke Philips N.V. Vestibular stimulation system
WO2009045296A1 (en) * 2007-10-01 2009-04-09 Medtronic, Inc. Gastric electrical stimulation with multi-site stimulation anti-desensitization feature
EP2254661B1 (en) 2008-02-14 2015-10-07 Cardiac Pacemakers, Inc. Apparatus for phrenic stimulation detection
US8473069B2 (en) 2008-02-28 2013-06-25 Proteus Digital Health, Inc. Integrated circuit implementation and fault control system, device, and method
US8204603B2 (en) 2008-04-25 2012-06-19 Cyberonics, Inc. Blocking exogenous action potentials by an implantable medical device
US8447413B2 (en) * 2008-04-29 2013-05-21 Medtronic, Inc. Configuring stimulation therapy using stimulation intensity
US20090287266A1 (en) * 2008-05-13 2009-11-19 Mark Zdeblick High-voltage tolerant multiplex multi-electrode stimulation systems and methods for using the same
WO2010011969A1 (en) 2008-07-24 2010-01-28 Boston Scientific Neuromodulation Corporation System and method for avoiding, reversing, and managing neurological accomodation to electrical stimulation
US8788042B2 (en) 2008-07-30 2014-07-22 Ecole Polytechnique Federale De Lausanne (Epfl) Apparatus and method for optimized stimulation of a neurological target
US8923981B2 (en) 2008-10-03 2014-12-30 Duke University Non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders
US11013924B2 (en) 2008-10-03 2021-05-25 Duke University Non-regular electrical stimulation patterns for treating neurological disorders
US8798755B2 (en) 2008-10-03 2014-08-05 Duke University Non-regular electrical stimulation patterns for treating neurological disorders
US9802046B2 (en) 2008-10-03 2017-10-31 Duke University Non-regular electrical stimulation patterns for improved efficiency in treating Parkinson's Disease
AU2016269469B2 (en) * 2008-10-03 2018-01-18 Duke University Non-regular electrical stimulation patterns for treating neurological disorders
CN102238978B (en) 2008-10-03 2014-09-24 杜克大学 Non-regular electrical stimulation patterns for treating neurological disorders
US9393418B2 (en) 2011-06-03 2016-07-19 Great Lakes Neuro Technologies Inc. Movement disorder therapy system, devices and methods of tuning
US8249701B2 (en) * 2008-10-15 2012-08-21 Spinal Modulation, Inc. Methods, devices and systems for programming neurostimulation
US8457747B2 (en) 2008-10-20 2013-06-04 Cyberonics, Inc. Neurostimulation with signal duration determined by a cardiac cycle
US8255057B2 (en) 2009-01-29 2012-08-28 Nevro Corporation Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions
US8311639B2 (en) 2009-07-08 2012-11-13 Nevro Corporation Systems and methods for adjusting electrical therapy based on impedance changes
US9327121B2 (en) 2011-09-08 2016-05-03 Nevro Corporation Selective high frequency spinal cord modulation for inhibiting pain, including cephalic and/or total body pain with reduced side effects, and associated systems and methods
US8788064B2 (en) 2008-11-12 2014-07-22 Ecole Polytechnique Federale De Lausanne Microfabricated neurostimulation device
US7974705B2 (en) 2008-11-13 2011-07-05 Proteus Biomedical, Inc. Multiplexed multi-electrode neurostimulation devices
WO2010056438A2 (en) 2008-11-13 2010-05-20 Proteus Biomedical, Inc. Shielded stimulation and sensing system and method
WO2010057063A2 (en) * 2008-11-13 2010-05-20 Proteus Biomedical, Inc. Pacing and stimulation system, device and method
US20100191304A1 (en) 2009-01-23 2010-07-29 Scott Timothy L Implantable Medical Device for Providing Chronic Condition Therapy and Acute Condition Therapy Using Vagus Nerve Stimulation
WO2010093720A1 (en) 2009-02-10 2010-08-19 Nevro Corporation Systems and methods for delivering neural therapy correlated with patient status
EP2756864B1 (en) 2009-04-22 2023-03-15 Nevro Corporation Spinal cord modulation systems for inducing paresthetic and anesthetic effects
US9764147B2 (en) * 2009-04-24 2017-09-19 Medtronic, Inc. Charge-based stimulation intensity programming with pulse amplitude and width adjusted according to a function
JP2012525206A (en) 2009-04-29 2012-10-22 プロテウス バイオメディカル インコーポレイテッド Method and apparatus for leads for implantable devices
WO2011011736A2 (en) 2009-07-23 2011-01-27 Proteus Biomedical, Inc. Solid-state thin film capacitor
US8498710B2 (en) 2009-07-28 2013-07-30 Nevro Corporation Linked area parameter adjustment for spinal cord stimulation and associated systems and methods
EP2506920B1 (en) 2009-12-01 2016-07-13 Ecole Polytechnique Fédérale de Lausanne Microfabricated surface neurostimulation device and method of making the same
US9002472B2 (en) * 2010-02-26 2015-04-07 Intelect Medical, Inc. Neuromodulation having non-linear dynamics
CN102917754B (en) * 2010-03-04 2015-03-25 弗兰霍菲尔运输应用研究公司 Electrode stimulation signal generation in a neural auditory prosthesis
WO2011121089A1 (en) 2010-04-01 2011-10-06 Ecole Polytechnique Federale De Lausanne (Epfl) Device for interacting with neurological tissue and methods of making and using the same
JP5847167B2 (en) 2010-05-27 2016-01-20 エヌディーアイ メディカル， エルエルシー Waveform shapes for neurological disorder treatment optimized for energy efficiency
US8825164B2 (en) 2010-06-11 2014-09-02 Enteromedics Inc. Neural modulation devices and methods
US20130218234A1 (en) * 2010-11-16 2013-08-22 Giuseppe Marineo Apparatus and method for rapid suppression of neuropathic, oncological, and paediatric pain
US9168374B2 (en) 2011-01-28 2015-10-27 Medtronic, Inc. Intra-burst pulse variation for stimulation therapy
WO2012158766A1 (en) * 2011-05-16 2012-11-22 Cardiac Pacemakers, Inc. Neurostimulation device with prevention of neural accommodation
US9814884B2 (en) 2011-11-04 2017-11-14 Nevro Corp. Systems and methods for detecting faults and/or adjusting electrical therapy based on impedance changes
US9238142B2 (en) * 2012-09-10 2016-01-19 Great Lakes Neurotechnologies Inc. Movement disorder therapy system and methods of tuning remotely, intelligently and/or automatically
US10758732B1 (en) * 2012-09-10 2020-09-01 Great Lakes Neurotechnologies Inc. Movement disorder therapy and brain mapping system and methods of tuning remotely, intelligently and/or automatically
US11844945B1 (en) * 2012-09-10 2023-12-19 Great Lakes Neurotechnologies Inc. Movement disorder therapy system, devices and methods of remotely tuning
US9211417B2 (en) * 2012-09-10 2015-12-15 Great Lakes Neurotechnologies Inc Movement disorder therapy system, devices and methods, and intelligent methods of tuning
WO2014040023A1 (en) 2012-09-10 2014-03-13 Great Lakes Neurotechnologies Inc. Movement disorder therapy system and methods of tuning remotely, intelligently and/or automatically
US9295840B1 (en) 2013-01-22 2016-03-29 Nevro Corporation Systems and methods for automatically programming patient therapy devices
US9895538B1 (en) 2013-01-22 2018-02-20 Nevro Corp. Systems and methods for deploying patient therapy devices
US9731133B1 (en) 2013-01-22 2017-08-15 Nevro Corp. Systems and methods for systematically testing a plurality of therapy programs in patient therapy devices
WO2014130071A1 (en) * 2013-02-19 2014-08-28 Duke University Non-regular electrical stimulation patterns for improved efficiency in treating parkinson's disease
WO2014159896A1 (en) * 2013-03-13 2014-10-02 Duke University Systems and methods for applying electrical stimulation for optimizing spinal cord stimulation
US9056195B2 (en) 2013-03-15 2015-06-16 Cyberonics, Inc. Optimization of cranial nerve stimulation to treat seizure disorderse during sleep
AU2014268445B2 (en) 2013-05-22 2019-03-07 Deep Brain Innovations LLC Deep brain stimulator and method of use
US10688306B2 (en) 2013-12-23 2020-06-23 Deep Brain Innovations LLC Programming systems for deep brain stimulator system
US9364667B1 (en) 2014-03-31 2016-06-14 Elassia LLC Potentiating or eliciting an erotic sensation in a body using electrostimulation
US9302109B2 (en) 2014-04-25 2016-04-05 Cyberonics, Inc. Cranial nerve stimulation to treat depression during sleep
US9585611B2 (en) 2014-04-25 2017-03-07 Cyberonics, Inc. Detecting seizures based on heartbeat data
US11311718B2 (en) 2014-05-16 2022-04-26 Aleva Neurotherapeutics Sa Device for interacting with neurological tissue and methods of making and using the same
EP3476430B1 (en) 2014-05-16 2020-07-01 Aleva Neurotherapeutics SA Device for interacting with neurological tissue
US9474894B2 (en) 2014-08-27 2016-10-25 Aleva Neurotherapeutics Deep brain stimulation lead
US9403011B2 (en) 2014-08-27 2016-08-02 Aleva Neurotherapeutics Leadless neurostimulator
US9925376B2 (en) 2014-08-27 2018-03-27 Aleva Neurotherapeutics Treatment of autoimmune diseases with deep brain stimulation
US9517344B1 (en) 2015-03-13 2016-12-13 Nevro Corporation Systems and methods for selecting low-power, effective signal delivery parameters for an implanted pulse generator
US11167139B2 (en) 2015-03-20 2021-11-09 Medtronic Sg, Llc Method and apparatus for multi modal electrical modulation of pain using composite electromagnetic fields
US10850102B2 (en) 2015-03-20 2020-12-01 Medtronic Sg, Llc Method and apparatus for multimodal electrical modulation of pain
AU2016235457B2 (en) 2015-03-20 2021-01-07 Medtronic Sg, Llc Method and apparatus for multimodal electrical modulation of pain
US9724521B2 (en) 2015-04-09 2017-08-08 Medtronic, Inc. Frequency based therapy generation
US11318310B1 (en) 2015-10-26 2022-05-03 Nevro Corp. Neuromodulation for altering autonomic functions, and associated systems and methods
US10105540B2 (en) 2015-11-09 2018-10-23 Bluewind Medical Ltd. Optimization of application of current
US10300277B1 (en) 2015-12-14 2019-05-28 Nevro Corp. Variable amplitude signals for neurological therapy, and associated systems and methods
CN109310865B (en) 2016-01-25 2022-09-13 内弗洛公司 Electrostimulation treatment of congestive heart failure, and associated systems and methods
US11045649B2 (en) * 2016-02-19 2021-06-29 Medtronic, Inc. Incontinence therapy
AU2017275585B2 (en) 2016-06-01 2022-03-17 Duke University Systems and methods for determining optimal temporal patterns of neural stimulation
US11045650B2 (en) 2016-12-06 2021-06-29 Medtronic, Inc. High frequency neurostimulation for pelvic symptom control
CN110418664B (en) 2017-04-07 2024-03-19 美敦力公司 Complex variation of electrical stimulation therapy parameters
US11135436B2 (en) 2017-05-12 2021-10-05 Cirtec Medical Corporation System, device, and method for generating stimulation waveform having a paresthesia-inducing low-frequency component and a spread-spectrum high-frequency component
US10702692B2 (en) 2018-03-02 2020-07-07 Aleva Neurotherapeutics Neurostimulation device
AU2019261983A1 (en) 2018-05-01 2020-12-10 Nevro Corp. A 2.4 GHz radio antenna for implanted medical devices, and associated systems and methods
US11590352B2 (en) 2019-01-29 2023-02-28 Nevro Corp. Ramped therapeutic signals for modulating inhibitory interneurons, and associated systems and methods
US11918811B2 (en) 2019-05-06 2024-03-05 Medtronic Sg, Llc Method and apparatus for multi modal or multiplexed electrical modulation of pain using composite electromagnetic fields
CN113420873B (en) * 2021-08-25 2021-12-10 北京科技大学 Intelligent early screening system for Alzheimer disease
WO2023220471A1 (en) * 2022-05-13 2023-11-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Thalamic stimulation system for the treatment of motor disorders

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE441810A (en) 1940-06-21
US3489152A (en) 1967-04-18 1970-01-13 Louis J Barbara Electrotherapeutic apparatus with body impedance-sensitive intensity regulation
SE346468B (en) 1969-02-24 1972-07-10 Lkb Medical Ab
US3822708A (en) 1972-12-07 1974-07-09 Clinical Technology Corp Electrical spinal cord stimulating device and method for management of pain
JPS6025138B2 (en) 1973-12-28 1985-06-17 宏 佐藤 Audio frequency band AC electric therapy device
US3983881A (en) 1975-05-21 1976-10-05 Telectronics Pty. Limited Muscle stimulator
US4121594A (en) 1977-09-26 1978-10-24 Med General, Inc. Transcutaneous electrical nerve stimulator
US4153059A (en) 1977-10-25 1979-05-08 Minnesota Mining And Manufacturing Company Urinary incontinence stimulator system
JPS54119792A (en) 1978-03-03 1979-09-17 Iriyou Kougaku Kenkiyuushiyo K Electric stimulation device for removing pain
US4210151A (en) 1978-09-26 1980-07-01 Stimtech, Inc. Electronic pain control with scanned output parameters
US4431000A (en) 1978-11-29 1984-02-14 Gatron Corporation Transcutaneous nerve stimulator with pseusorandom pulse generator
FR2500309A3 (en) 1981-02-25 1982-08-27 Faiveley Sa Electrical pulse generator producing analgesic effect - applies short rise time pulses, which are amplitude modulated and passed through wobbulator to affect human tissues
US4390023A (en) 1981-04-30 1983-06-28 Medtronic, Inc. Patterned electrical tissue stimulator
CA1215128A (en) 1982-12-08 1986-12-09 Pedro Molina-Negro Electric nerve stimulator device
US4556064A (en) 1983-01-25 1985-12-03 Bruce Pomeranz Electrotherapy acupuncture apparatus and method
FR2567762B1 (en) 1984-07-20 1989-04-14 Simonin Philippe DEVICE FOR THE AESTHETIC TREATMENT OF THE SKIN
US4699143A (en) 1985-06-17 1987-10-13 Minnesota Mining And Manufacturing Company Electrical simulator for biological tissue having remote control
US4706674A (en) 1985-06-17 1987-11-17 Minnesota Mining And Manufacturing Co. Electrical stimulator for biological tissue utilizing output current monitor
US4686991A (en) 1985-06-17 1987-08-18 Minnesota Mining And Manufacturing Company Electrical stimulator for biological tissue utilizing linear current output circuit
US4922908A (en) 1985-07-22 1990-05-08 Empi, Inc. Medical stimulator with stimulation signal characteristics modulated as a function of stimulation signal frequency
US4887603A (en) 1985-07-22 1989-12-19 Empi, Inc. Medical stimulator with stimulation signal characteristics modulated as a function of stimulation signal frequency
US4759368A (en) * 1986-12-02 1988-07-26 Medical Designs, Inc. Transcutaneous nerve stimulator
GB8904998D0 (en) 1989-03-04 1989-04-19 Matthews Tony Anaesthetising apparatus
US5069211A (en) 1989-08-25 1991-12-03 Staodyn, Inc. Microprocessor controlled electronic stimulating device having biphasic pulse output
US5184617A (en) * 1990-06-05 1993-02-09 Staodyn, Inc. Output pulse compensation for therapeutic-type electronic devices
GB2255719A (en) 1991-05-11 1992-11-18 Tony Matthews Electro-therapy apparatus
JP2988613B2 (en) 1995-08-08 1999-12-13 東洋産業株式会社 Low frequency treatment device
US5683422A (en) 1996-04-25 1997-11-04 Medtronic, Inc. Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation
US5792212A (en) 1997-03-07 1998-08-11 Medtronic, Inc. Nerve evoked potential measurement system using chaotic sequences for noise rejection
US5978560A (en) * 1997-11-07 1999-11-02 Xerox Corporation Load balancing of distributed printing systems using enhanced printer attributes
US6498656B1 (en) * 1998-08-26 2002-12-24 International Business Machines Corporation Rule based selection criteria for controlling print job distribution
US6529286B1 (en) * 1998-12-22 2003-03-04 Canon Kabushiki Kaisha Dynamic printing interface for routing print jobs in a computer network
US6188929B1 (en) 1999-07-15 2001-02-13 Joseph Giordano Sequentially generated multi-parameter bio-electric delivery system and method
US6762852B1 (en) * 1999-10-05 2004-07-13 Hewlett-Packard Development Company, Lp. Print feature selection based on combined features of several printers
US6466822B1 (en) * 2000-04-05 2002-10-15 Neuropace, Inc. Multimodal neurostimulator and process of using it
US6701190B2 (en) * 2000-10-10 2004-03-02 Meagan Medical, Inc. System and method for varying characteristics of electrical therapy
CA2328568A1 (en) * 2000-12-12 2002-06-12 Universite De Sherbrooke Implantable, programmable nerve prosthesis
US7127296B2 (en) * 2001-11-02 2006-10-24 Advanced Bionics Corporation Method for increasing the therapeutic ratio/usage range in a neurostimulator
US7050856B2 (en) * 2002-01-11 2006-05-23 Medtronic, Inc. Variation of neural-stimulation parameters

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US7050856B2 (en) 2006-05-23
US20030135248A1 (en) 2003-07-17
US20060190061A1 (en) 2006-08-24
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US9724514B2 (en) 2017-08-08
US7873418B2 (en) 2011-01-18

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