WO2003066021A3 - Drug nanoparticles with lysozyme surface stabiliser - Google Patents
Drug nanoparticles with lysozyme surface stabiliser Download PDFInfo
- Publication number
- WO2003066021A3 WO2003066021A3 PCT/US2003/001083 US0301083W WO03066021A3 WO 2003066021 A3 WO2003066021 A3 WO 2003066021A3 US 0301083 W US0301083 W US 0301083W WO 03066021 A3 WO03066021 A3 WO 03066021A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- drug nanoparticles
- lysozyme
- surface stabiliser
- lysozyme surface
- stabiliser
- Prior art date
Links
- 102000016943 Muramidase Human genes 0.000 title abstract 2
- 108010014251 Muramidase Proteins 0.000 title abstract 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 title abstract 2
- 229960000274 lysozyme Drugs 0.000 title abstract 2
- 235000010335 lysozyme Nutrition 0.000 title abstract 2
- 239000004325 lysozyme Substances 0.000 title abstract 2
- 239000003381 stabilizer Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000002105 nanoparticle Substances 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/327—Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
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- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
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- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
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- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S977/701—Integrated with dissimilar structures on a common substrate
- Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S977/715—On an organic substrate
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S977/734—Fullerenes, i.e. graphene-based structures, such as nanohorns, nanococoons, nanoscrolls or fullerene-like structures, e.g. WS2 or MoS2 chalcogenide nanotubes, planar C3N4, etc.
- Y10S977/735—Carbon buckyball
- Y10S977/737—Carbon buckyball having a modified surface
- Y10S977/738—Modified with biological, organic, or hydrocarbon material
- Y10S977/739—Modified with an enzyme
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/914—Protein engineering
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03737537A EP1471887B1 (en) | 2002-02-04 | 2003-02-04 | Nanoparticulate compositions having lysozyme as a surface stabilizer |
DE60332212T DE60332212D1 (en) | 2002-02-04 | 2003-02-04 | DRUG OPEN NANOPARTICLES WITH LYSOCYM SURFACE STABILIZER |
DK03737537.5T DK1471887T3 (en) | 2002-02-04 | 2003-02-04 | Nanoparticle compositions having lysozyme as a surface stabilizer |
AU2003210517A AU2003210517A1 (en) | 2002-02-04 | 2003-02-04 | Drug nanoparticles with lysozyme surface stabiliser |
AT03737537T ATE464880T1 (en) | 2002-02-04 | 2003-02-04 | MEDICINAL NANOPARTICLES WITH LYSOZYME SURFACE STABILIZER |
CA2475092A CA2475092C (en) | 2002-02-04 | 2003-02-04 | Nanoparticulate compositions having lysozyme as a surface stabilizer |
JP2003565446A JP4598399B2 (en) | 2002-02-04 | 2003-02-04 | Nanoparticle composition with lysozyme as surface stabilizer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35323002P | 2002-02-04 | 2002-02-04 | |
US60/353,230 | 2002-02-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003066021A2 WO2003066021A2 (en) | 2003-08-14 |
WO2003066021A3 true WO2003066021A3 (en) | 2004-04-01 |
Family
ID=27734284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/001083 WO2003066021A2 (en) | 2002-02-04 | 2003-02-04 | Drug nanoparticles with lysozyme surface stabiliser |
Country Status (11)
Country | Link |
---|---|
US (4) | US7459283B2 (en) |
EP (1) | EP1471887B1 (en) |
JP (1) | JP4598399B2 (en) |
AT (1) | ATE464880T1 (en) |
AU (1) | AU2003210517A1 (en) |
CA (1) | CA2475092C (en) |
DE (1) | DE60332212D1 (en) |
DK (1) | DK1471887T3 (en) |
ES (1) | ES2343405T3 (en) |
PT (1) | PT1471887E (en) |
WO (1) | WO2003066021A2 (en) |
Families Citing this family (72)
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JP4613275B2 (en) | 1998-11-02 | 2011-01-12 | エラン ファーマ インターナショナル,リミティド | Multiparticulate modified release composition |
US7198795B2 (en) * | 2000-09-21 | 2007-04-03 | Elan Pharma International Ltd. | In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions |
US7758890B2 (en) | 2001-06-23 | 2010-07-20 | Lyotropic Therapeutics, Inc. | Treatment using dantrolene |
US20030129242A1 (en) * | 2002-01-04 | 2003-07-10 | Bosch H. William | Sterile filtered nanoparticulate formulations of budesonide and beclomethasone having tyloxapol as a surface stabilizer |
ATE464880T1 (en) | 2002-02-04 | 2010-05-15 | Elan Pharma Int Ltd | MEDICINAL NANOPARTICLES WITH LYSOZYME SURFACE STABILIZER |
CA2479665C (en) * | 2002-03-20 | 2011-08-30 | Elan Pharma International Ltd. | Nanoparticulate compositions of angiogenesis inhibitors |
EP1556091A1 (en) * | 2002-10-04 | 2005-07-27 | Elan Pharma International Limited | Gamma irradiation of solid nanoparticulate active agents |
US20040208833A1 (en) * | 2003-02-04 | 2004-10-21 | Elan Pharma International Ltd. | Novel fluticasone formulations |
EP1611883A1 (en) * | 2003-03-26 | 2006-01-04 | Menicon Co., Ltd. | Composition for ophthalmic use |
CA2523035C (en) * | 2003-05-22 | 2011-04-26 | Elan Pharma International Ltd. | Sterilization of dispersions of nanoparticulate active agents with gamma radiation |
AR047759A1 (en) * | 2003-09-26 | 2006-02-22 | Vertex Pharma | FENIL DERIVATIVES - PIPERAZINE AS MODULATORS OF MUSCARNIC RECEPTORS |
US7879360B2 (en) | 2003-11-05 | 2011-02-01 | Elan Pharma International, Ltd. | Nanoparticulate compositions having a peptide as a surface stabilizer |
KR100603974B1 (en) | 2003-12-05 | 2006-07-25 | 김갑식 | Method for preparing nano-scale or amorphous particle using solid fat as a solvent |
US10335757B2 (en) * | 2004-03-05 | 2019-07-02 | Specialty Earth Sciences | Process for making environmental reactant(s) |
EP2623095A1 (en) * | 2004-11-16 | 2013-08-07 | Elan Pharma International Limited | Injectable nanoparticulate olanzapine formulations |
JP2008540546A (en) * | 2005-05-10 | 2008-11-20 | エラン ファーマ インターナショナル リミテッド | Nanoparticulate clopidogrel formulation |
WO2006132752A1 (en) * | 2005-05-10 | 2006-12-14 | Elan Pharma International Limited | Nanoparticulate and controlled release compositions comprising vitamin k2 |
WO2007053197A2 (en) * | 2005-06-03 | 2007-05-10 | Elan Pharma International, Limited | Nanoparticulate acetaminophen formulations |
US20070042049A1 (en) * | 2005-06-03 | 2007-02-22 | Elan Pharma International, Limited | Nanoparticulate benidipine compositions |
US20060275372A1 (en) * | 2005-06-03 | 2006-12-07 | Elan Pharma International Limited | Nanoparticulate imatinib mesylate formulations |
DE112006001606T5 (en) | 2005-06-08 | 2009-07-09 | Elan Pharma International Ltd., Athlone | Nanoparticulate and controlled release composition comprising cefditoren |
ATE446742T1 (en) * | 2005-06-09 | 2009-11-15 | Elan Pharma Int Ltd | NANOPARTICULAR EBASTIN FORMULATIONS |
KR20080016952A (en) * | 2005-06-13 | 2008-02-22 | 엘란 파마 인터내셔널 리미티드 | Nanoparticulate clopidogrel and aspirin combination formulations |
CA2612384A1 (en) * | 2005-06-15 | 2006-12-28 | Elan Pharma International, Limited | Nanoparticulate azelnidipine formulations |
US8277788B2 (en) | 2005-08-03 | 2012-10-02 | Conopco, Inc. | Quick dispersing hair conditioning composition |
WO2007033239A2 (en) * | 2005-09-13 | 2007-03-22 | Elan Pharma International, Limited | Nanoparticulate tadalafil formulations |
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2003
- 2003-02-04 AT AT03737537T patent/ATE464880T1/en active
- 2003-02-04 CA CA2475092A patent/CA2475092C/en not_active Expired - Lifetime
- 2003-02-04 PT PT03737537T patent/PT1471887E/en unknown
- 2003-02-04 JP JP2003565446A patent/JP4598399B2/en not_active Expired - Lifetime
- 2003-02-04 WO PCT/US2003/001083 patent/WO2003066021A2/en active Application Filing
- 2003-02-04 DE DE60332212T patent/DE60332212D1/en not_active Expired - Lifetime
- 2003-02-04 DK DK03737537.5T patent/DK1471887T3/en active
- 2003-02-04 AU AU2003210517A patent/AU2003210517A1/en not_active Abandoned
- 2003-02-04 EP EP03737537A patent/EP1471887B1/en not_active Expired - Lifetime
- 2003-02-04 US US10/357,514 patent/US7459283B2/en active Active
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-
2008
- 2008-11-12 US US12/292,091 patent/US8323641B2/en active Active
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US20090074875A1 (en) | 2009-03-19 |
ATE464880T1 (en) | 2010-05-15 |
PT1471887E (en) | 2010-07-16 |
US20130224123A1 (en) | 2013-08-29 |
EP1471887A2 (en) | 2004-11-03 |
US8323641B2 (en) | 2012-12-04 |
JP4598399B2 (en) | 2010-12-15 |
US7459283B2 (en) | 2008-12-02 |
DK1471887T3 (en) | 2010-06-07 |
DE60332212D1 (en) | 2010-06-02 |
JP2005523900A (en) | 2005-08-11 |
US20140234225A1 (en) | 2014-08-21 |
AU2003210517A8 (en) | 2003-09-02 |
CA2475092C (en) | 2012-05-01 |
US8652464B2 (en) | 2014-02-18 |
WO2003066021A2 (en) | 2003-08-14 |
ES2343405T3 (en) | 2010-07-30 |
EP1471887B1 (en) | 2010-04-21 |
AU2003210517A1 (en) | 2003-09-02 |
CA2475092A1 (en) | 2003-08-14 |
US20030185869A1 (en) | 2003-10-02 |
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