WO2003067236A3 - Segmented side-to-side faims - Google Patents

Segmented side-to-side faims Download PDF

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Publication number
WO2003067236A3
WO2003067236A3 PCT/CA2003/000169 CA0300169W WO03067236A3 WO 2003067236 A3 WO2003067236 A3 WO 2003067236A3 CA 0300169 W CA0300169 W CA 0300169W WO 03067236 A3 WO03067236 A3 WO 03067236A3
Authority
WO
WIPO (PCT)
Prior art keywords
outer electrode
segment
electrode
inner electrode
segments
Prior art date
Application number
PCT/CA2003/000169
Other languages
French (fr)
Other versions
WO2003067236A2 (en
Inventor
Roger Guevremont
Randy Purves
David Barnett
Original Assignee
Ionalytics Corp
Roger Guevremont
Randy Purves
David Barnett
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionalytics Corp, Roger Guevremont, Randy Purves, David Barnett filed Critical Ionalytics Corp
Priority to CA002475555A priority Critical patent/CA2475555A1/en
Priority to US10/503,714 priority patent/US7034289B2/en
Priority to AU2003203089A priority patent/AU2003203089A1/en
Publication of WO2003067236A2 publication Critical patent/WO2003067236A2/en
Publication of WO2003067236A3 publication Critical patent/WO2003067236A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3504—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

Provided is a side-to-side high field asymmetric waveform ion mobility spectrometer (FAIMS) including a generally cylindrically-shaped inner electrode (62). Encircling the inner electrode is a generally cylindrically-shaped outer electrode assembly comprising at least first and second and third outer electrode segments (64-68). Each of the outer electrode segments has a channel extending therethrough and open at opposite ends thereof. In an assembled condition, the second outer electrode segment is disposed intermediate the first and third outer electrode segments in an end-to-end arrangement. An electrical contact is provided on at least one of the inner electrode and the second outer electrode segment for receiving a first direct current voltage between the inner electrode and the second outer electrode segment, and for applying an asymmetric waveform voltage to the at least one of the inner electrode and the second outer electrode segment. The second outer electrode segment is maintained at a different potential relative to the first and third outer electrode segments, such that a potential gradient is formed in a direction along the length of the inner electrode.
PCT/CA2003/000169 2002-02-08 2003-02-07 Segmented side-to-side faims WO2003067236A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002475555A CA2475555A1 (en) 2002-02-08 2003-02-07 Segmented side-to-side faims
US10/503,714 US7034289B2 (en) 2002-02-08 2003-02-07 Segmented side-to-side FAIMS
AU2003203089A AU2003203089A1 (en) 2002-02-08 2003-02-07 Segmented side-to-side faims

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35471102P 2002-02-08 2002-02-08
US60/354,711 2002-02-08

Publications (2)

Publication Number Publication Date
WO2003067236A2 WO2003067236A2 (en) 2003-08-14
WO2003067236A3 true WO2003067236A3 (en) 2003-10-09

Family

ID=27734410

Family Applications (8)

Application Number Title Priority Date Filing Date
PCT/CA2003/000007 WO2003067244A2 (en) 2002-02-08 2003-01-09 Faims with non-destructive detection of selectively transmitted ions
PCT/CA2003/000171 WO2003067237A2 (en) 2002-02-08 2003-02-07 Faims apparatus and method using carrier gases that contain a trace amount of a dopant species
PCT/CA2003/000169 WO2003067236A2 (en) 2002-02-08 2003-02-07 Segmented side-to-side faims
PCT/CA2003/000170 WO2003067261A1 (en) 2002-02-08 2003-02-07 Method for distinguishing between protein variants
PCT/CA2003/000172 WO2003067242A1 (en) 2002-02-08 2003-02-07 Faims apparatus and method for detecting trace amounts of a vapour in a carrier gas
PCT/CA2003/000173 WO2003067625A1 (en) 2002-02-08 2003-02-07 Method and apparatus for desolvating ions for introduction into a faims analyzer region
PCT/CA2003/000175 WO2003067243A1 (en) 2002-02-08 2003-02-07 Side-to-side faims apparatus having an analyzer region with non-uniform spacing and method therefore
PCT/CA2003/000174 WO2003067624A1 (en) 2002-02-08 2003-02-07 Faims apparatus having plural ion inlets and method therefore

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/CA2003/000007 WO2003067244A2 (en) 2002-02-08 2003-01-09 Faims with non-destructive detection of selectively transmitted ions
PCT/CA2003/000171 WO2003067237A2 (en) 2002-02-08 2003-02-07 Faims apparatus and method using carrier gases that contain a trace amount of a dopant species

Family Applications After (5)

Application Number Title Priority Date Filing Date
PCT/CA2003/000170 WO2003067261A1 (en) 2002-02-08 2003-02-07 Method for distinguishing between protein variants
PCT/CA2003/000172 WO2003067242A1 (en) 2002-02-08 2003-02-07 Faims apparatus and method for detecting trace amounts of a vapour in a carrier gas
PCT/CA2003/000173 WO2003067625A1 (en) 2002-02-08 2003-02-07 Method and apparatus for desolvating ions for introduction into a faims analyzer region
PCT/CA2003/000175 WO2003067243A1 (en) 2002-02-08 2003-02-07 Side-to-side faims apparatus having an analyzer region with non-uniform spacing and method therefore
PCT/CA2003/000174 WO2003067624A1 (en) 2002-02-08 2003-02-07 Faims apparatus having plural ion inlets and method therefore

Country Status (5)

Country Link
US (7) US6787765B2 (en)
EP (5) EP1481415A1 (en)
AU (8) AU2003201232A1 (en)
CA (8) CA2475608A1 (en)
WO (8) WO2003067244A2 (en)

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