WO2003067237A3 - Faims apparatus and method using carrier gases that contain a trace amount of a dopant species - Google Patents

Faims apparatus and method using carrier gases that contain a trace amount of a dopant species Download PDF

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Publication number
WO2003067237A3
WO2003067237A3 PCT/CA2003/000171 CA0300171W WO03067237A3 WO 2003067237 A3 WO2003067237 A3 WO 2003067237A3 CA 0300171 W CA0300171 W CA 0300171W WO 03067237 A3 WO03067237 A3 WO 03067237A3
Authority
WO
WIPO (PCT)
Prior art keywords
ion
interest
carrier gas
trace amount
analyzer region
Prior art date
Application number
PCT/CA2003/000171
Other languages
French (fr)
Other versions
WO2003067237A2 (en
Inventor
Roger Guevremont
Randy Purves
David Barnett
Barbara Ells
Original Assignee
Ionalytics Corp
Roger Guevremont
Randy Purves
David Barnett
Barbara Ells
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionalytics Corp, Roger Guevremont, Randy Purves, David Barnett, Barbara Ells filed Critical Ionalytics Corp
Priority to CA2474684A priority Critical patent/CA2474684C/en
Priority to EP03701396A priority patent/EP1474677A2/en
Priority to AU2003203091A priority patent/AU2003203091A1/en
Priority to US10/503,713 priority patent/US7026612B2/en
Publication of WO2003067237A2 publication Critical patent/WO2003067237A2/en
Publication of WO2003067237A3 publication Critical patent/WO2003067237A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3504—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Abstract

Disclosed is a method and apparatus for improving at least one of a peak separation and a signal intensity relating to an ion of interest being transmitted through an analyzer region of a FAIMS apparatus (70). A method according to the instant invention includes a step of introducing ions including an ion of interest into an analyzer region of a FAIMS. A flow of a doped carrier gas other than air is also provided through the analyzer region. The doped carrier gas includes a carrier gas and a trace amount of a predetermined dopant gas, the predetermined dopant gas selected for improving at least one of a peak separation and a signal intensity relating to the ion of interest relative to the peak separation and the signal intensity relating to the ion of interest in the presence of the carrier gas only. The ion of interest is selectively transmitted through the analyzer region in the presence of the doped carrier gas, and detected at a detector (74).
PCT/CA2003/000171 2002-02-08 2003-02-07 Faims apparatus and method using carrier gases that contain a trace amount of a dopant species WO2003067237A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2474684A CA2474684C (en) 2002-02-08 2003-02-07 Faims apparatus and method using carrier gases that contain a trace amount of a dopant species
EP03701396A EP1474677A2 (en) 2002-02-08 2003-02-07 Faims apparatus and method using carrier gases that contain a trace amount of a dopant species
AU2003203091A AU2003203091A1 (en) 2002-02-08 2003-02-07 Faims apparatus and method using carrier gases that contain a trace amount of a dopant species
US10/503,713 US7026612B2 (en) 2002-02-08 2003-02-07 FAIMS apparatus and method using carrier gases that contain a trace amount of a dopant species

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35471102P 2002-02-08 2002-02-08
US60/354,711 2002-02-08

Publications (2)

Publication Number Publication Date
WO2003067237A2 WO2003067237A2 (en) 2003-08-14
WO2003067237A3 true WO2003067237A3 (en) 2003-10-16

Family

ID=27734410

Family Applications (8)

Application Number Title Priority Date Filing Date
PCT/CA2003/000007 WO2003067244A2 (en) 2002-02-08 2003-01-09 Faims with non-destructive detection of selectively transmitted ions
PCT/CA2003/000171 WO2003067237A2 (en) 2002-02-08 2003-02-07 Faims apparatus and method using carrier gases that contain a trace amount of a dopant species
PCT/CA2003/000169 WO2003067236A2 (en) 2002-02-08 2003-02-07 Segmented side-to-side faims
PCT/CA2003/000170 WO2003067261A1 (en) 2002-02-08 2003-02-07 Method for distinguishing between protein variants
PCT/CA2003/000172 WO2003067242A1 (en) 2002-02-08 2003-02-07 Faims apparatus and method for detecting trace amounts of a vapour in a carrier gas
PCT/CA2003/000173 WO2003067625A1 (en) 2002-02-08 2003-02-07 Method and apparatus for desolvating ions for introduction into a faims analyzer region
PCT/CA2003/000175 WO2003067243A1 (en) 2002-02-08 2003-02-07 Side-to-side faims apparatus having an analyzer region with non-uniform spacing and method therefore
PCT/CA2003/000174 WO2003067624A1 (en) 2002-02-08 2003-02-07 Faims apparatus having plural ion inlets and method therefore

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/CA2003/000007 WO2003067244A2 (en) 2002-02-08 2003-01-09 Faims with non-destructive detection of selectively transmitted ions

Family Applications After (6)

Application Number Title Priority Date Filing Date
PCT/CA2003/000169 WO2003067236A2 (en) 2002-02-08 2003-02-07 Segmented side-to-side faims
PCT/CA2003/000170 WO2003067261A1 (en) 2002-02-08 2003-02-07 Method for distinguishing between protein variants
PCT/CA2003/000172 WO2003067242A1 (en) 2002-02-08 2003-02-07 Faims apparatus and method for detecting trace amounts of a vapour in a carrier gas
PCT/CA2003/000173 WO2003067625A1 (en) 2002-02-08 2003-02-07 Method and apparatus for desolvating ions for introduction into a faims analyzer region
PCT/CA2003/000175 WO2003067243A1 (en) 2002-02-08 2003-02-07 Side-to-side faims apparatus having an analyzer region with non-uniform spacing and method therefore
PCT/CA2003/000174 WO2003067624A1 (en) 2002-02-08 2003-02-07 Faims apparatus having plural ion inlets and method therefore

Country Status (5)

Country Link
US (7) US6787765B2 (en)
EP (5) EP1481415A1 (en)
AU (8) AU2003201232A1 (en)
CA (8) CA2475608A1 (en)
WO (8) WO2003067244A2 (en)

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