WO2003067252A3 - Electrochemical biosensor strip for analysis of liquid samples - Google Patents

Electrochemical biosensor strip for analysis of liquid samples Download PDF

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Publication number
WO2003067252A3
WO2003067252A3 PCT/US2003/001764 US0301764W WO03067252A3 WO 2003067252 A3 WO2003067252 A3 WO 2003067252A3 US 0301764 W US0301764 W US 0301764W WO 03067252 A3 WO03067252 A3 WO 03067252A3
Authority
WO
WIPO (PCT)
Prior art keywords
electrode
electrodes
sample
reaction zone
biosensor
Prior art date
Application number
PCT/US2003/001764
Other languages
French (fr)
Other versions
WO2003067252A2 (en
Inventor
Shridhara A Karinka
Geoffrey R Chambers
Gurdial Sanghera
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to BR0305257-5A priority Critical patent/BR0305257A/en
Priority to CA2474912A priority patent/CA2474912C/en
Priority to JP2003566551A priority patent/JP4879459B2/en
Priority to EP03703930A priority patent/EP1472537A2/en
Priority to AU2003205258A priority patent/AU2003205258A1/en
Priority to MXPA04007411A priority patent/MXPA04007411A/en
Publication of WO2003067252A2 publication Critical patent/WO2003067252A2/en
Publication of WO2003067252A3 publication Critical patent/WO2003067252A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis

Abstract

A biosensor in the form of a strip. In one embodiment, the biosensor strip comprises an electrode support, a first electrode, i. e., a working electrode, a second electrode, i.e., a counter electrode, and a third electrode, i.e., a reference electrode. Each of the electrodes is disposed on and supported by the electrode support. Each of the electrodes is spaced apart from the other two electrodes. The biosensor strip can include a covering layer, which defines an enclosed space over the electrodes. This enclosed space includes a zone where an analyte in the sample reacts with reagent(s) deposited at the working electrode. This zone is referred to as the reaction zone. The covering layer has an aperture for receiving a sample for introduction into the reaction zone. The biosensor strip can also include at least one layer of mesh interposed in the enclosed space between the covering layer and the electrodes in the reaction zone. This layer of mesh facilitates transporting of the sample to the electrodes in the reaction zone. In another embodiment, a biosensor strip can be constructed to provide a configuration that will allow the sample to be introduced to the reaction zone by action of capillary force. In this embodiment, the layer of mesh can be omitted. The invention also provides a method for determining the concentration of glucose in a sample of whole blood by using the biosensor of this invention.
PCT/US2003/001764 2002-02-01 2003-01-21 Electrochemical biosensor strip for analysis of liquid samples WO2003067252A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BR0305257-5A BR0305257A (en) 2002-02-01 2003-01-21 Electrochemical biosensor blade for liquid sample analysis
CA2474912A CA2474912C (en) 2002-02-01 2003-01-21 Electrochemical biosensor strip for analysis of liquid samples
JP2003566551A JP4879459B2 (en) 2002-02-01 2003-01-21 Electrochemical biosensor strip for analysis of liquid samples
EP03703930A EP1472537A2 (en) 2002-02-01 2003-01-21 Electrochemical biosensor strip for analysis of liquid samples
AU2003205258A AU2003205258A1 (en) 2002-02-01 2003-01-21 Electrochemical biosensor strip for analysis of liquid samples
MXPA04007411A MXPA04007411A (en) 2002-02-01 2003-01-21 Electrochemical biosensor strip for analysis of liquid samples.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/062,313 2002-02-01
US10/062,313 US6863800B2 (en) 2002-02-01 2002-02-01 Electrochemical biosensor strip for analysis of liquid samples

Publications (2)

Publication Number Publication Date
WO2003067252A2 WO2003067252A2 (en) 2003-08-14
WO2003067252A3 true WO2003067252A3 (en) 2003-09-25

Family

ID=27658554

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/001764 WO2003067252A2 (en) 2002-02-01 2003-01-21 Electrochemical biosensor strip for analysis of liquid samples

Country Status (10)

Country Link
US (1) US6863800B2 (en)
EP (1) EP1472537A2 (en)
JP (2) JP4879459B2 (en)
AR (1) AR038461A1 (en)
AU (1) AU2003205258A1 (en)
BR (1) BR0305257A (en)
CA (1) CA2474912C (en)
MX (1) MXPA04007411A (en)
TW (1) TW200305017A (en)
WO (1) WO2003067252A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9410915B2 (en) 2004-06-18 2016-08-09 Roche Operations Ltd. System and method for quality assurance of a biosensor test strip

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