WO2003070182A3 - Sodium channel blockers - Google Patents
Sodium channel blockers Download PDFInfo
- Publication number
- WO2003070182A3 WO2003070182A3 PCT/US2003/004817 US0304817W WO03070182A3 WO 2003070182 A3 WO2003070182 A3 WO 2003070182A3 US 0304817 W US0304817 W US 0304817W WO 03070182 A3 WO03070182 A3 WO 03070182A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sodium channel
- channel blockers
- present
- variety
- treatment
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
- C07D241/30—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms in which said hetero-bound carbon atoms are part of a substructure —C(=X)—X—C(=X)—X— in which X is an oxygen or sulphur atom or an imino radical, e.g. imidoylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
- C07D241/30—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms in which said hetero-bound carbon atoms are part of a substructure —C(=X)—X—C(=X)—X— in which X is an oxygen or sulphur atom or an imino radical, e.g. imidoylguanidines
- C07D241/32—(Amino-pyrazinoyl) guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Abstract
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020107027168A KR101225201B1 (en) | 2002-02-19 | 2003-02-19 | Sodium channel blockers |
JP2003569142A JP4557550B2 (en) | 2002-02-19 | 2003-02-19 | Sodium channel blocker |
EP03742810A EP1485360B1 (en) | 2002-02-19 | 2003-02-19 | Sodium channel blockers |
AT03742810T ATE520674T1 (en) | 2002-02-19 | 2003-02-19 | SODIUM CHANNEL BLOCKERS |
KR1020047012934A KR101008728B1 (en) | 2002-02-19 | 2003-02-19 | Sodium channel blockers |
US10/532,110 US20060142306A1 (en) | 2002-02-19 | 2003-02-19 | Sodium channel blockers |
DK03742810.9T DK1485360T3 (en) | 2002-02-19 | 2003-02-19 | sodium |
AU2003211135A AU2003211135B2 (en) | 2002-02-19 | 2003-02-19 | Sodium channel blockers |
ES03742810T ES2374130T3 (en) | 2002-02-19 | 2003-02-19 | BLOCKERS OF SODIUM CHANNELS. |
SI200332076T SI1485360T1 (en) | 2002-02-19 | 2003-02-19 | Sodium channel blockers |
KR1020107027167A KR101183274B1 (en) | 2002-02-19 | 2003-02-19 | Sodium channel blockers |
CA2476430A CA2476430C (en) | 2002-02-19 | 2003-02-19 | Sodium channel blockers |
HK05103365.6A HK1070369A1 (en) | 2002-02-19 | 2005-04-20 | Sodium channel blockers |
US12/179,353 US8198286B2 (en) | 2002-02-19 | 2008-07-24 | Sodium channel blockers |
US13/492,711 US8846688B2 (en) | 2002-02-19 | 2012-06-08 | Sodium channel blockers |
US14/158,441 US20140179625A1 (en) | 2002-02-19 | 2014-01-17 | Sodium channel blockers |
US14/727,189 US20150376146A1 (en) | 2002-02-19 | 2015-06-01 | Sodium channel blockers |
US15/336,574 US10167266B2 (en) | 2002-02-19 | 2016-10-27 | Sodium channel blockers |
US16/181,230 US20190241528A1 (en) | 2002-02-19 | 2018-11-05 | Sodium channel blockers |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/076,571 | 2002-02-19 | ||
US10/076,571 US6858615B2 (en) | 2002-02-19 | 2002-02-19 | Phenyl guanidine sodium channel blockers |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/076,571 Continuation US6858615B2 (en) | 2002-02-19 | 2002-02-19 | Phenyl guanidine sodium channel blockers |
US10/076,571 Continuation-In-Part US6858615B2 (en) | 2002-02-19 | 2002-02-19 | Phenyl guanidine sodium channel blockers |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10532110 A-371-Of-International | 2003-02-19 | ||
US10/532,110 A-371-Of-International US20060142306A1 (en) | 2002-02-19 | 2003-02-19 | Sodium channel blockers |
US12/179,353 Continuation US8198286B2 (en) | 2002-02-19 | 2008-07-24 | Sodium channel blockers |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003070182A2 WO2003070182A2 (en) | 2003-08-28 |
WO2003070182A3 true WO2003070182A3 (en) | 2003-12-24 |
Family
ID=27752677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/004817 WO2003070182A2 (en) | 2002-02-19 | 2003-02-19 | Sodium channel blockers |
Country Status (14)
Country | Link |
---|---|
US (15) | US6858615B2 (en) |
EP (1) | EP1485360B1 (en) |
JP (2) | JP4557550B2 (en) |
KR (3) | KR101008728B1 (en) |
AT (1) | ATE520674T1 (en) |
AU (2) | AU2003211135B2 (en) |
CA (1) | CA2476430C (en) |
CY (1) | CY1112906T1 (en) |
DK (1) | DK1485360T3 (en) |
ES (1) | ES2374130T3 (en) |
HK (1) | HK1070369A1 (en) |
PT (1) | PT1485360E (en) |
SI (1) | SI1485360T1 (en) |
WO (1) | WO2003070182A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9586911B2 (en) | 2013-12-13 | 2017-03-07 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epthelial sodium channel blocking compounds |
US9586910B2 (en) | 2011-06-27 | 2017-03-07 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl(2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide |
US9593084B2 (en) | 2012-12-17 | 2017-03-14 | Parion Sciences, Inc. | Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6858615B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
US6858614B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
US6903105B2 (en) * | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
KR20060115348A (en) * | 2003-08-18 | 2006-11-08 | 패리온 사이언스 인코퍼레이티드 | Alaphatic pyrazinoylguanidine sodium channel blockers |
US20050090505A1 (en) * | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
PT1663235E (en) * | 2003-08-18 | 2013-10-29 | Parion Sciences Inc | Capped pyrazinoylguanidine sodium channel blockers |
US7317013B2 (en) * | 2003-08-18 | 2008-01-08 | Parion Sciences, Inc. | Cyclic pyrazinoylguanidine sodium channel blockers |
US7745442B2 (en) * | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
WO2005049050A1 (en) * | 2003-11-19 | 2005-06-02 | Meiji Seika Kaisha, Ltd. | Sialagogue and, containing the same, oral composition and food composition |
GB0403864D0 (en) * | 2004-02-20 | 2004-03-24 | Ucl Ventures | Modulator |
US7399766B2 (en) | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
CA2575680A1 (en) * | 2004-08-18 | 2006-03-02 | Michael R. Johnson | Cyclic amide & ester pyrazinoylguanidine sodium channel blockers |
WO2006023573A2 (en) * | 2004-08-18 | 2006-03-02 | Johnson Michael R | Aliphatic amide & ester pyrazinoylguanidine sodium channel blockers |
US20070021439A1 (en) * | 2005-07-25 | 2007-01-25 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers |
US7807834B2 (en) * | 2005-08-03 | 2010-10-05 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
AU2012201188B2 (en) * | 2005-08-03 | 2013-02-07 | Parion Sciences, Inc. | New capped pyrazinoylguanidine sodium channel blockers |
GB0526244D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
SI2035004T1 (en) * | 2006-06-09 | 2012-12-31 | Parion Sciences, Inc. | Phenyl substituted pyrazinoylguanidine sodium channel blockers possessing beta agonist activity |
CA2653757A1 (en) * | 2006-06-09 | 2007-12-21 | Parion Sciences, Inc. | Aliphatic pyrazinoylguanidine sodium channel blockers with beta agonist activity |
CA2653773A1 (en) * | 2006-06-09 | 2007-12-21 | Parion Sciences, Inc. | Cyclic substituted pyrazinoylguanidine sodium channel blockers possessing beta agonist activity |
EP2059237A4 (en) * | 2006-09-07 | 2010-06-30 | Parion Sciences Inc | Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
EP2059239A4 (en) * | 2006-09-07 | 2010-07-07 | Parion Sciences Inc | Enhanced mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
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