WO2003070751A3 - Partial peptide mimetics and methods - Google Patents

Partial peptide mimetics and methods Download PDF

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Publication number
WO2003070751A3
WO2003070751A3 PCT/US2003/005106 US0305106W WO03070751A3 WO 2003070751 A3 WO2003070751 A3 WO 2003070751A3 US 0305106 W US0305106 W US 0305106W WO 03070751 A3 WO03070751 A3 WO 03070751A3
Authority
WO
WIPO (PCT)
Prior art keywords
partial peptide
peptide mimetics
methods
homolog
seq
Prior art date
Application number
PCT/US2003/005106
Other languages
French (fr)
Other versions
WO2003070751A2 (en
Inventor
Kevin H Mayo
Thomas R Hoye
Lavey Carolee Flader
Original Assignee
Univ Minnesota
Kevin H Mayo
Thomas R Hoye
Lavey Carolee Flader
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota, Kevin H Mayo, Thomas R Hoye, Lavey Carolee Flader filed Critical Univ Minnesota
Priority to EP03742842A priority Critical patent/EP1572719A4/en
Priority to JP2003569658A priority patent/JP2005536453A/en
Priority to CA002476427A priority patent/CA2476427A1/en
Priority to AU2003211163A priority patent/AU2003211163A1/en
Publication of WO2003070751A2 publication Critical patent/WO2003070751A2/en
Publication of WO2003070751A3 publication Critical patent/WO2003070751A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Partial peptide mimetics and methods of making and using, wherein the partial peptide mimetics have a first amino acid sequence comprising ANIKLSVQMKL (SEQ ID NO: 8), a homolog thereof, or a segment of SEQ ID NO: 8 or a homolog thereof, a second amino acid sequence comprising IIVKLND (SEQ ID NO:2), a homolog thereof, or a segment of SEQ ID NO:2 or a homolog thereof, and a β-turn inducing scaffold bonded between the first and second amino acid sequences.
PCT/US2003/005106 2002-02-20 2003-02-20 Partial peptide mimetics and methods WO2003070751A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP03742842A EP1572719A4 (en) 2002-02-20 2003-02-20 Partial peptide mimetics and methods
JP2003569658A JP2005536453A (en) 2002-02-20 2003-02-20 Partial peptide mimetics and methods
CA002476427A CA2476427A1 (en) 2002-02-20 2003-02-20 Partial peptide mimetics and methods
AU2003211163A AU2003211163A1 (en) 2002-02-20 2003-02-20 Partial peptide mimetics and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35927202P 2002-02-20 2002-02-20
US60/359,272 2002-02-20

Publications (2)

Publication Number Publication Date
WO2003070751A2 WO2003070751A2 (en) 2003-08-28
WO2003070751A3 true WO2003070751A3 (en) 2007-04-05

Family

ID=27757772

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/005106 WO2003070751A2 (en) 2002-02-20 2003-02-20 Partial peptide mimetics and methods

Country Status (6)

Country Link
US (2) US7056514B2 (en)
EP (1) EP1572719A4 (en)
JP (1) JP2005536453A (en)
AU (1) AU2003211163A1 (en)
CA (1) CA2476427A1 (en)
WO (1) WO2003070751A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0939766A2 (en) * 1996-05-24 1999-09-08 The Regents Of The University Of Minnesota Synthesis of soluble beta-sheet forming peptides
US7056514B2 (en) * 2002-02-20 2006-06-06 Regents Of The University Of Minnesota Partial peptide mimetics and methods
RU2005111253A (en) * 2002-09-18 2005-11-20 Сантр Оспиталье Де Л` Юниверсите Де Монреаль (Схюм) (Ca) GHRH ANALOGUES
AU2004285122A1 (en) * 2003-10-17 2005-05-12 Regents Of The University Of Minnesota Modified polypeptides with therapeutic activity and methods of use
US20060053172A1 (en) * 2004-09-03 2006-03-09 Biowisdom Limited System and method for creating, editing, and using multi-relational ontologies
PT1802291E (en) 2004-10-04 2012-03-12 Univ Minnesota Calixarene-based peptide conformation mimetics, methods of use, and methods of making
JP2010519338A (en) * 2007-03-01 2010-06-03 マリンクロット インコーポレイテッド Embedded photoactive peptides and uses thereof
CN101687040A (en) * 2007-03-01 2010-03-31 马林克罗特公司 Integrated photoactive small molecules and uses thereof
CA2695197C (en) * 2007-07-31 2017-08-15 Mallinckrodt Inc. Integrated photoactive agents and uses thereof
WO2020002765A1 (en) 2018-06-29 2020-01-02 Glykos Biomedical Oy Conjugates
WO2021123506A1 (en) 2019-12-18 2021-06-24 Glykos Biomedical Oy Stabile conjugate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955577A (en) * 1996-06-27 1999-09-21 Regents Of The University Of Minnesota Method for synthesizing a water-soluble β-sheet forming peptide
US6486125B1 (en) * 1996-05-24 2002-11-26 Regents Of The University Of Minnesota Synthesis of soluble β-sheet forming peptides
US7056514B2 (en) * 2002-02-20 2006-06-06 Regents Of The University Of Minnesota Partial peptide mimetics and methods

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001486A1 (en) 1987-08-11 1989-02-23 New York University Biologically active bactericidal/permeability-increasing protein fragments
US5198541A (en) 1987-08-11 1993-03-30 New York University Dna encoding bactericidal/permeability-increasing proteins
US5171739A (en) 1989-02-14 1992-12-15 Incyte Pharmaceuticals, Inc. Treatment of endotoxin-associated shock and preventation thereof using a BPI protein
US5089274A (en) 1989-02-14 1992-02-18 Incyte Pharmaceuticals, Inc. Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat endotoxin-related disorders
US5334584A (en) 1989-02-14 1994-08-02 Incyte Pharamaceuticals, Inc. Recombinant, non-glycosylated bpi protein and uses thereof
US5234912A (en) 1989-02-14 1993-08-10 Incyte Pharmaceuticals, Inc. Pharmaceutical compositions comprising recombinant BPI proteins and a lipid carrier and uses thereof
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5595887A (en) 1990-07-16 1997-01-21 Bionebraska, Inc. Purification directed cloning of peptides using carbonic anhydrase as the affinity binding segment
WO1992009695A1 (en) 1990-11-28 1992-06-11 E.I. Du Pont De Nemours And Company Structural proteins from artificial genes
EP0563222B1 (en) 1990-12-03 1998-02-25 New York University Biologically active bactericidal/permeability-increasing protein fragments
US5190873A (en) 1991-06-21 1993-03-02 California Institute Of Biological Research Hybrid tryptophan aporepressor containing ligand binding sites
AU4382193A (en) 1992-05-19 1993-12-13 Xoma Corporation BPI-immunoglobulin fusion proteins
RU95117103A (en) 1992-12-28 1997-06-10 Ниппон Синяку Компани Лимитед (JP) Derivatives of quinoline carboxylic acid and methods of their synthesis
US5420019A (en) 1993-02-02 1995-05-30 Xoma Corporation Stable bactericidal/permeability-increasing protein muteins
DE69428521T2 (en) 1993-02-02 2002-05-23 Xoma Technology Ltd MEDICINAL COMPOSITIONS CONTAINING A BACTERICIDAL PERMEABILITY-INCREASING PROTEIN AND A SURFACTANT
US5348942A (en) 1993-03-12 1994-09-20 Xoma Corporation Therapeutic uses of bactericidal/permeability increasing protein products
ATE169304T1 (en) 1993-03-12 1998-08-15 Xoma Corp BIOLOGICALLY ACTIVE PEPTIDES FROM FUNCTIONAL DOMAIN OF THE BACTERICIDE/PERMEABILITY-INCREASE PROTEINS AND THEIR USE
JPH08511682A (en) 1993-04-30 1996-12-10 インサイト ファーマシューティカルズ，インク． Recombinant BPI protein and LBP protein, nucleic acid molecule encoding the same, production method thereof and use thereof
AU7175694A (en) 1993-06-17 1995-01-17 Xoma Corporation Lipopolysaccharide binding protein derivatives
DE69431922T2 (en) 1993-07-02 2003-11-13 Incyte Pharma Inc GLYCOSILIZED AND NONGLYCOLIZED BACTERICIDES / PERMEABILITY INCREASING PROTEINS AND METHODS FOR THEIR PRODUCTION
WO1995002414A1 (en) 1993-07-14 1995-01-26 Xoma Corporation Method for potentiating bpi protein product bactericidal activity by administration of lbp protein products
US5447913A (en) 1994-03-11 1995-09-05 Xoma Corporation Therapeutic uses of bactericidal/permeability-increasing protein dimer products
US5786324A (en) 1994-03-24 1998-07-28 Regents Of The University Of Minnesota Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
US5830860A (en) 1994-03-24 1998-11-03 Regents Of The University Of Minnesota Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
US5639725A (en) 1994-04-26 1997-06-17 Children's Hospital Medical Center Corp. Angiostatin protein
US5837682A (en) 1996-03-08 1998-11-17 The Children's Medical Center Corporation Angiostatin fragments and method of use
GB9506806D0 (en) 1995-04-01 1995-05-24 Univ Leeds Improvements relating to polymers
WO1996037212A1 (en) 1995-05-26 1996-11-28 Torrey Pines Institute For Molecular Studies POLYPEPTIDE COMPOUNDS THAT FORM β SHEETS
US5854205A (en) 1995-10-23 1998-12-29 The Children's Medical Center Corporation Therapeutic antiangiogenic compositions and methods
ES2252187T3 (en) 2000-01-20 2006-05-16 Regents Of The University Of Minnesota PEPTIDES WITH ANTIBACTERIAL ACTIVITY.
AU2004285122A1 (en) 2003-10-17 2005-05-12 Regents Of The University Of Minnesota Modified polypeptides with therapeutic activity and methods of use
ITPD20040171A1 (en) 2004-06-29 2004-09-29 Maus Spa DEVICE FOR THE LOCKING OF PARTS SUBJECT TO MECHANICAL PROCESSING AND MACHINE TOOL INCLUDING THIS DEVICE
PT1802291E (en) 2004-10-04 2012-03-12 Univ Minnesota Calixarene-based peptide conformation mimetics, methods of use, and methods of making
US20070010438A1 (en) * 2005-07-08 2007-01-11 Mayo Kevin H Tumor treatment using beta-sheet peptides and radiotherapy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486125B1 (en) * 1996-05-24 2002-11-26 Regents Of The University Of Minnesota Synthesis of soluble β-sheet forming peptides
US5955577A (en) * 1996-06-27 1999-09-21 Regents Of The University Of Minnesota Method for synthesizing a water-soluble β-sheet forming peptide
US7056514B2 (en) * 2002-02-20 2006-06-06 Regents Of The University Of Minnesota Partial peptide mimetics and methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1572719A4 *

Also Published As

Publication number Publication date
EP1572719A2 (en) 2005-09-14
CA2476427A1 (en) 2003-08-28
AU2003211163A1 (en) 2003-09-09
WO2003070751A2 (en) 2003-08-28
US7056514B2 (en) 2006-06-06
US20060128629A1 (en) 2006-06-15
AU2003211163A8 (en) 2003-09-09
US20040053828A1 (en) 2004-03-18
EP1572719A4 (en) 2007-11-14
JP2005536453A (en) 2005-12-02
US7339023B2 (en) 2008-03-04

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