WO2003070751A3 - Partial peptide mimetics and methods - Google Patents

Partial peptide mimetics and methods Download PDF

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Publication number
WO2003070751A3
WO2003070751A3 PCT/US2003/005106 US0305106W WO03070751A3 WO 2003070751 A3 WO2003070751 A3 WO 2003070751A3 US 0305106 W US0305106 W US 0305106W WO 03070751 A3 WO03070751 A3 WO 03070751A3
Authority
WO
WIPO (PCT)
Prior art keywords
partial peptide
peptide mimetics
methods
homolog
seq
Prior art date
Application number
PCT/US2003/005106
Other languages
French (fr)
Other versions
WO2003070751A2 (en
Inventor
Kevin H Mayo
Thomas R Hoye
Lavey Carolee Flader
Original Assignee
Univ Minnesota
Kevin H Mayo
Thomas R Hoye
Lavey Carolee Flader
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota, Kevin H Mayo, Thomas R Hoye, Lavey Carolee Flader filed Critical Univ Minnesota
Priority to AU2003211163A priority Critical patent/AU2003211163A1/en
Priority to EP03742842A priority patent/EP1572719A4/en
Priority to CA002476427A priority patent/CA2476427A1/en
Priority to JP2003569658A priority patent/JP2005536453A/en
Publication of WO2003070751A2 publication Critical patent/WO2003070751A2/en
Publication of WO2003070751A3 publication Critical patent/WO2003070751A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Partial peptide mimetics and methods of making and using, wherein the partial peptide mimetics have a first amino acid sequence comprising ANIKLSVQMKL (SEQ ID NO: 8), a homolog thereof, or a segment of SEQ ID NO: 8 or a homolog thereof, a second amino acid sequence comprising IIVKLND (SEQ ID NO:2), a homolog thereof, or a segment of SEQ ID NO:2 or a homolog thereof, and a β-turn inducing scaffold bonded between the first and second amino acid sequences.
PCT/US2003/005106 2002-02-20 2003-02-20 Partial peptide mimetics and methods WO2003070751A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2003211163A AU2003211163A1 (en) 2002-02-20 2003-02-20 Partial peptide mimetics and methods
EP03742842A EP1572719A4 (en) 2002-02-20 2003-02-20 Partial peptide mimetics and methods
CA002476427A CA2476427A1 (en) 2002-02-20 2003-02-20 Partial peptide mimetics and methods
JP2003569658A JP2005536453A (en) 2002-02-20 2003-02-20 Partial peptide mimetics and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35927202P 2002-02-20 2002-02-20
US60/359,272 2002-02-20

Publications (2)

Publication Number Publication Date
WO2003070751A2 WO2003070751A2 (en) 2003-08-28
WO2003070751A3 true WO2003070751A3 (en) 2007-04-05

Family

ID=27757772

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/005106 WO2003070751A2 (en) 2002-02-20 2003-02-20 Partial peptide mimetics and methods

Country Status (6)

Country Link
US (2) US7056514B2 (en)
EP (1) EP1572719A4 (en)
JP (1) JP2005536453A (en)
AU (1) AU2003211163A1 (en)
CA (1) CA2476427A1 (en)
WO (1) WO2003070751A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000511892A (en) * 1996-05-24 2000-09-12 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Synthesis of soluble beta-sheet forming peptide
JP2005536453A (en) * 2002-02-20 2005-12-02 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Partial peptide mimetics and methods
BR0314619A (en) * 2002-09-18 2005-08-02 Univ Montreal Ct Hospitalier Chum Ghrh's analogs
CA2541856A1 (en) * 2003-10-17 2005-05-12 Regents Of The University Of Minnesota Modified polypeptides with therapeutic activity and methods of use
US20060053172A1 (en) * 2004-09-03 2006-03-09 Biowisdom Limited System and method for creating, editing, and using multi-relational ontologies
CA2867023A1 (en) 2004-10-04 2006-04-20 Kevin H. Mayo Calixarene-based peptide conformation mimetics, methods of use, and methods of making
EP2131861A2 (en) * 2007-03-01 2009-12-16 Mallinckrodt Inc. Integrated photoactive small molecules and uses thereof
CN101626786A (en) * 2007-03-01 2010-01-13 马林克罗特公司 Integrated photoactive peptides and uses thereof
WO2009018405A1 (en) * 2007-07-31 2009-02-05 Mallinckrodt Inc. Integrated photoactive agents and uses thereof
JP2021529163A (en) 2018-06-29 2021-10-28 グリコス バイオメディカル オーワイ Conjugate
US20230038373A1 (en) 2019-12-18 2023-02-09 Glykos Biomedical Oy Stabile conjugate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955577A (en) * 1996-06-27 1999-09-21 Regents Of The University Of Minnesota Method for synthesizing a water-soluble β-sheet forming peptide
US6486125B1 (en) * 1996-05-24 2002-11-26 Regents Of The University Of Minnesota Synthesis of soluble β-sheet forming peptides
US7056514B2 (en) * 2002-02-20 2006-06-06 Regents Of The University Of Minnesota Partial peptide mimetics and methods

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US6486125B1 (en) * 1996-05-24 2002-11-26 Regents Of The University Of Minnesota Synthesis of soluble β-sheet forming peptides
US5955577A (en) * 1996-06-27 1999-09-21 Regents Of The University Of Minnesota Method for synthesizing a water-soluble β-sheet forming peptide
US7056514B2 (en) * 2002-02-20 2006-06-06 Regents Of The University Of Minnesota Partial peptide mimetics and methods

Non-Patent Citations (1)

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Also Published As

Publication number Publication date
US7056514B2 (en) 2006-06-06
EP1572719A2 (en) 2005-09-14
WO2003070751A2 (en) 2003-08-28
AU2003211163A1 (en) 2003-09-09
US20040053828A1 (en) 2004-03-18
US7339023B2 (en) 2008-03-04
CA2476427A1 (en) 2003-08-28
EP1572719A4 (en) 2007-11-14
AU2003211163A8 (en) 2003-09-09
JP2005536453A (en) 2005-12-02
US20060128629A1 (en) 2006-06-15

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