WO2003072084A1 - Fast disintegrating tablets - Google Patents
Fast disintegrating tablets Download PDFInfo
- Publication number
- WO2003072084A1 WO2003072084A1 PCT/GB2003/000844 GB0300844W WO03072084A1 WO 2003072084 A1 WO2003072084 A1 WO 2003072084A1 GB 0300844 W GB0300844 W GB 0300844W WO 03072084 A1 WO03072084 A1 WO 03072084A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tablet
- agglomerates
- fast disintegrating
- disintegrating tablet
- superdisintegrant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
Definitions
- Rapid disintegrating tablets are known.
- EP 0281200 discloses a pharmaceutical tablet comprising an amphoteric ⁇ - lactam antibiotic, and as disintegrants, a cellulose product and low-substituted hydroxypropylcellulose, in which the cellulose product is microcrystalline or microfine cellulose or a mixture of both.
- the tablet may be formed by compressing a granule of ⁇ -lactam antibiotic and microcrystalline cellulose and/or microfine cellulose.
- Powdered mannitol was separately agglomerated with purified water in a Diosna granulator and dried in a Niro fluid bed drier at 60°C.
- the cross-linked povidone agglomerates (13 parts) were then blended in with 86 parts of agglomerated mannitol and 1 part of magnesium stearate to form a tablet mixture. Tabletting was carried out using magnesium stearate to form a tablet mixture. Tabletting was carried out using a Manesty ® F3 press and 10mm normal concave punches. The tablets weighted 310 grams, had a hardness of 1.5kp and an EP disintegration time of 10.5 seconds.
- Disintegration of the tablet was carried out by placing one tablet on the tongue of the subject. The subject was instructed not to bite the tablet but allowed to
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/505,916 US20050169986A1 (en) | 2002-02-28 | 2003-02-28 | Fast disintegrating tablets |
AU2003208459A AU2003208459A1 (en) | 2002-02-28 | 2003-02-28 | Fast disintegrating tablets |
CA002476170A CA2476170A1 (en) | 2002-02-28 | 2003-02-28 | Fast disintegrating tablets |
EP03706747A EP1478346A1 (en) | 2002-02-28 | 2003-02-28 | Fast disintegrating tablets |
JP2003570830A JP2005525353A (en) | 2002-02-28 | 2003-02-28 | Fast disintegrating tablets |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0204771.0A GB0204771D0 (en) | 2002-02-28 | 2002-02-28 | Fast disintegrating tablets |
GB0204771.0 | 2002-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003072084A1 true WO2003072084A1 (en) | 2003-09-04 |
Family
ID=9932019
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2003/000844 WO2003072084A1 (en) | 2002-02-28 | 2003-02-28 | Fast disintegrating tablets |
Country Status (8)
Country | Link |
---|---|
US (1) | US20050169986A1 (en) |
EP (1) | EP1478346A1 (en) |
JP (1) | JP2005525353A (en) |
AU (1) | AU2003208459A1 (en) |
CA (1) | CA2476170A1 (en) |
GB (1) | GB0204771D0 (en) |
WO (1) | WO2003072084A1 (en) |
ZA (1) | ZA200406193B (en) |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004017976A1 (en) * | 2002-08-21 | 2004-03-04 | Phoqus Pharmaceuticals Limited, | Fast dissolving and taste masked oral dosage form comprising sildenafil |
WO2004017947A1 (en) * | 2002-08-21 | 2004-03-04 | Phoqus Pharmaceuticals Limited | Use of an aqueous solution of citric acid and a water-soluble sugar like lactitol as granulation liquid in the manufacture of tablets |
EP1595533A1 (en) * | 2003-01-21 | 2005-11-16 | Nippon Shinyaku Co., Ltd. | Tablet quickly melting in oral cavity |
WO2007071580A1 (en) * | 2005-12-21 | 2007-06-28 | Basf Se | Finely dispersed cross-linked polyvinylpyrrolidone for use as tablet disintegrant |
WO2007071581A2 (en) * | 2005-12-21 | 2007-06-28 | Basf Se | Pharmaceutical formulation for producing rapidly disintegrating tablets |
US7390524B1 (en) | 2004-05-20 | 2008-06-24 | Advanced Cardiovascular Systems, Inc. | Method for electrostatic spraying of an abluminal stent surface |
WO2008086023A1 (en) * | 2007-01-10 | 2008-07-17 | Hercules Incorporated | Use of agglomerated hydroxyethylcellulose in pharmaceutical, personal care and household care applications |
JPWO2007011018A1 (en) * | 2005-07-22 | 2009-02-05 | 田辺三菱製薬株式会社 | Orally disintegrating tablets |
US7799351B2 (en) | 1997-09-19 | 2010-09-21 | Ineos Healthcare Limited | Metal compounds, mixed or sulphated, as phosphate binders |
DE102009016584A1 (en) | 2009-04-06 | 2010-10-07 | Ratiopharm Gmbh | Orodispersible tablet containing a sildenafil salt |
US7811604B1 (en) | 2005-11-14 | 2010-10-12 | Barr Laboratories, Inc. | Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same |
US7838029B1 (en) * | 2003-07-31 | 2010-11-23 | Watson Laboratories, Inc. | Mirtazapine solid dosage forms |
WO2012003987A1 (en) * | 2010-07-08 | 2012-01-12 | Ratiopharm Gmbh | Oral dosage form of deferasirox |
US8097292B2 (en) | 2004-04-27 | 2012-01-17 | Advanced Cardiovascular Systems, Inc, | Methods for electrostatic coating of an abluminal stent surface |
US8568780B2 (en) | 2007-06-06 | 2013-10-29 | Basf Se | Pharmaceutical formulation for the production of rapidly disintegrating tablets |
US8841446B2 (en) | 2002-07-16 | 2014-09-23 | Bayer Intellectual Property Gmbh | Medicaments containing vardenafil hydrochloride trihydrate |
US9066917B2 (en) | 2009-08-03 | 2015-06-30 | Cytochroma Development Inc. | Mixed metal compound |
US9168270B2 (en) | 2006-01-31 | 2015-10-27 | Opko Ireland Global Holdings, Ltd. | Water-insoluble, iron-containing mixed metal, granular material |
WO2015176008A1 (en) * | 2014-05-16 | 2015-11-19 | Vivus, Inc. | Orally disintegrating dosage form for administration of avanafil, and associated methods of manufacture and use |
US9566302B2 (en) | 2010-02-04 | 2017-02-14 | Opko Ireland Global Holdings, Ltd. | Composition comprising mixed metal compounds and xanthan gum |
US10155040B2 (en) | 2007-10-16 | 2018-12-18 | Opko Ireland Global Holdings, Ltd. | Mixed metal compounds for treatment of hyperphosphataemia |
US10201501B2 (en) | 2007-07-27 | 2019-02-12 | Opko Ireland Global Holdings, Ltd. | Mixed metal compounds used as antacids |
US10406105B2 (en) | 2007-06-06 | 2019-09-10 | Basf Se | Pharmaceutical formulation for the production of rapidly disintegrating tablets |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1893956A (en) * | 2003-07-25 | 2007-01-10 | 沃纳奇尔科特公司 | Doxycycline metal complex in a solid dosage form |
US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
DK1928409T3 (en) | 2005-09-12 | 2012-11-05 | Actelion Pharmaceuticals Ltd | STABLE PHARMACEUTICAL COMPOSITION INCLUDING PYRIMIDINE SULFAMIDE |
US8445037B2 (en) * | 2008-10-28 | 2013-05-21 | A. M. Todd Company | Volatile distillate by-product of mint oil that promotes absorption and/or bioavailability of compounds of bio-medical and nutritional interest |
TW201028168A (en) * | 2008-12-19 | 2010-08-01 | Solvay Pharm Bv | Precompacted fast-disintegrating formulations of compounds with a low oral bioavailability |
ES2596324T3 (en) * | 2009-12-18 | 2017-01-05 | Mitsubishi Tanabe Pharma Corporation | Preparation of teneligliptin with stabilized elution |
US20110150993A1 (en) * | 2009-12-22 | 2011-06-23 | Fmc Corporation | Fine Particle Croscarmellose and Uses Thereof |
GB201303781D0 (en) * | 2013-03-04 | 2013-04-17 | Gauthier Pierre Pascal | Oral timer device and method of using same |
US20160008310A1 (en) | 2014-07-11 | 2016-01-14 | Azanta A/S | Misoprostol dispersible tablet |
MX2017000399A (en) * | 2014-07-11 | 2017-08-10 | Azanta Danmark As | Misoprostol dispersible tablet. |
WO2017112672A1 (en) | 2015-12-23 | 2017-06-29 | Colgate-Palmolive Company | Storage-stable solid peroxymonosulfate composition |
PT3446684T (en) * | 2016-06-16 | 2021-12-16 | Towa Pharmaceutical Co Ltd | Orally disintegrating tablet |
EP3484588B1 (en) | 2016-08-11 | 2023-07-26 | Colgate-Palmolive Company | Peroxymonosulfate toothpowder composition for tenacious stains |
US20220233415A1 (en) | 2021-01-25 | 2022-07-28 | Colgate-Palmolive Company | Solid Oral Care Compositions |
US20220339082A1 (en) | 2021-04-23 | 2022-10-27 | Colgate-Palmolive Company | Solid Oral Care Compositions |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5464632A (en) * | 1991-07-22 | 1995-11-07 | Laboratoires Prographarm | Rapidly disintegratable multiparticular tablet |
WO1999044580A1 (en) * | 1998-03-06 | 1999-09-10 | Eurand International S.P.A. | Fast disintegrating tablets |
WO2000078292A1 (en) * | 1999-06-18 | 2000-12-28 | Takeda Chemical Industries, Ltd. | Quickly disintegrating solid preparations |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2679451B1 (en) * | 1991-07-22 | 1994-09-09 | Prographarm Laboratoires | MULTIPARTICLE TABLET WITH RAPID DELIVERY. |
JP2001058944A (en) * | 1999-06-18 | 2001-03-06 | Takeda Chem Ind Ltd | Rapidly disintegrating solid formulation |
KR20020062323A (en) * | 1999-12-06 | 2002-07-25 | 펜웨스트 파머슈티칼즈 컴파니 | Pharmaceutical superdisintegrant |
-
2002
- 2002-02-28 GB GBGB0204771.0A patent/GB0204771D0/en not_active Ceased
-
2003
- 2003-02-28 CA CA002476170A patent/CA2476170A1/en not_active Abandoned
- 2003-02-28 JP JP2003570830A patent/JP2005525353A/en active Pending
- 2003-02-28 WO PCT/GB2003/000844 patent/WO2003072084A1/en active Application Filing
- 2003-02-28 US US10/505,916 patent/US20050169986A1/en not_active Abandoned
- 2003-02-28 EP EP03706747A patent/EP1478346A1/en not_active Withdrawn
- 2003-02-28 AU AU2003208459A patent/AU2003208459A1/en not_active Abandoned
-
2004
- 2004-08-03 ZA ZA200406193A patent/ZA200406193B/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5464632A (en) * | 1991-07-22 | 1995-11-07 | Laboratoires Prographarm | Rapidly disintegratable multiparticular tablet |
US5464632C1 (en) * | 1991-07-22 | 2001-02-20 | Prographarm Lab | Rapidly disintegratable multiparticular tablet |
WO1999044580A1 (en) * | 1998-03-06 | 1999-09-10 | Eurand International S.P.A. | Fast disintegrating tablets |
WO2000078292A1 (en) * | 1999-06-18 | 2000-12-28 | Takeda Chemical Industries, Ltd. | Quickly disintegrating solid preparations |
EP1203580A1 (en) * | 1999-06-18 | 2002-05-08 | Takeda Chemical Industries, Ltd. | Quickly disintegrating solid preparations |
Non-Patent Citations (1)
Title |
---|
KIBBE A.: "Handbook of Pharmaceutical Excipients", 2000, PHARM. PRESS, LONDON, XP002248285, 24820 * |
Cited By (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7799351B2 (en) | 1997-09-19 | 2010-09-21 | Ineos Healthcare Limited | Metal compounds, mixed or sulphated, as phosphate binders |
US9242869B2 (en) | 1997-09-19 | 2016-01-26 | Opko Ireland Global Holdings, Ltd. | Metal compounds mixed or sulphated, as phosphate binders |
US8841446B2 (en) | 2002-07-16 | 2014-09-23 | Bayer Intellectual Property Gmbh | Medicaments containing vardenafil hydrochloride trihydrate |
WO2004017947A1 (en) * | 2002-08-21 | 2004-03-04 | Phoqus Pharmaceuticals Limited | Use of an aqueous solution of citric acid and a water-soluble sugar like lactitol as granulation liquid in the manufacture of tablets |
WO2004017976A1 (en) * | 2002-08-21 | 2004-03-04 | Phoqus Pharmaceuticals Limited, | Fast dissolving and taste masked oral dosage form comprising sildenafil |
US8580305B2 (en) | 2003-01-21 | 2013-11-12 | Tomoharu Suga | Tablet quickly melting in oral cavity |
EP1595533A4 (en) * | 2003-01-21 | 2006-11-29 | Nippon Shinyaku Co Ltd | Tablet quickly melting in oral cavity |
EP1595533A1 (en) * | 2003-01-21 | 2005-11-16 | Nippon Shinyaku Co., Ltd. | Tablet quickly melting in oral cavity |
US7838029B1 (en) * | 2003-07-31 | 2010-11-23 | Watson Laboratories, Inc. | Mirtazapine solid dosage forms |
US8097292B2 (en) | 2004-04-27 | 2012-01-17 | Advanced Cardiovascular Systems, Inc, | Methods for electrostatic coating of an abluminal stent surface |
US7390524B1 (en) | 2004-05-20 | 2008-06-24 | Advanced Cardiovascular Systems, Inc. | Method for electrostatic spraying of an abluminal stent surface |
JPWO2007011018A1 (en) * | 2005-07-22 | 2009-02-05 | 田辺三菱製薬株式会社 | Orally disintegrating tablets |
JP4739340B2 (en) * | 2005-07-22 | 2011-08-03 | 田辺三菱製薬株式会社 | Orally disintegrating tablets |
US7811604B1 (en) | 2005-11-14 | 2010-10-12 | Barr Laboratories, Inc. | Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same |
US8425935B2 (en) | 2005-12-21 | 2013-04-23 | Basf Se | Pharmaceutical formulation for producing rapidly disintegrating tablets |
WO2007071581A2 (en) * | 2005-12-21 | 2007-06-28 | Basf Se | Pharmaceutical formulation for producing rapidly disintegrating tablets |
WO2007071580A1 (en) * | 2005-12-21 | 2007-06-28 | Basf Se | Finely dispersed cross-linked polyvinylpyrrolidone for use as tablet disintegrant |
US8597679B2 (en) | 2005-12-21 | 2013-12-03 | Basf Se | Fine-particle crosslinked polyvinylpyrrolidone as tablet disintegrant |
WO2007071581A3 (en) * | 2005-12-21 | 2008-01-10 | Basf Ag | Pharmaceutical formulation for producing rapidly disintegrating tablets |
US9168270B2 (en) | 2006-01-31 | 2015-10-27 | Opko Ireland Global Holdings, Ltd. | Water-insoluble, iron-containing mixed metal, granular material |
US9907816B2 (en) | 2006-01-31 | 2018-03-06 | Opko Ireland Global Holdings, Ltd. | Water-insoluble, iron-containing mixed metal, granular material |
WO2008086023A1 (en) * | 2007-01-10 | 2008-07-17 | Hercules Incorporated | Use of agglomerated hydroxyethylcellulose in pharmaceutical, personal care and household care applications |
US8728448B2 (en) | 2007-01-10 | 2014-05-20 | Hercules Incorporated | Use of agglomerated hydroxyethylcellulose in pharmaceutical, personal care and household care applications |
US8568780B2 (en) | 2007-06-06 | 2013-10-29 | Basf Se | Pharmaceutical formulation for the production of rapidly disintegrating tablets |
US10406105B2 (en) | 2007-06-06 | 2019-09-10 | Basf Se | Pharmaceutical formulation for the production of rapidly disintegrating tablets |
US10201501B2 (en) | 2007-07-27 | 2019-02-12 | Opko Ireland Global Holdings, Ltd. | Mixed metal compounds used as antacids |
US10155040B2 (en) | 2007-10-16 | 2018-12-18 | Opko Ireland Global Holdings, Ltd. | Mixed metal compounds for treatment of hyperphosphataemia |
DE102009016584A1 (en) | 2009-04-06 | 2010-10-07 | Ratiopharm Gmbh | Orodispersible tablet containing a sildenafil salt |
WO2010115576A1 (en) | 2009-04-06 | 2010-10-14 | Ratiopharm Gmbh | Melting tablet containing a sildenafil salt |
US9066917B2 (en) | 2009-08-03 | 2015-06-30 | Cytochroma Development Inc. | Mixed metal compound |
US9314481B2 (en) | 2009-08-03 | 2016-04-19 | Opko Ireland Global Holdings, Ltd. | Method |
US9566302B2 (en) | 2010-02-04 | 2017-02-14 | Opko Ireland Global Holdings, Ltd. | Composition comprising mixed metal compounds and xanthan gum |
EP2929877A1 (en) * | 2010-07-08 | 2015-10-14 | ratiopharm GmbH | Oral dosage form of deferasirox |
US8703203B2 (en) | 2010-07-08 | 2014-04-22 | Ratiopharm Gmbh | Oral dosage form of deferasirox |
WO2012003987A1 (en) * | 2010-07-08 | 2012-01-12 | Ratiopharm Gmbh | Oral dosage form of deferasirox |
WO2015176008A1 (en) * | 2014-05-16 | 2015-11-19 | Vivus, Inc. | Orally disintegrating dosage form for administration of avanafil, and associated methods of manufacture and use |
US10028916B2 (en) | 2014-05-16 | 2018-07-24 | Vivus, Inc. | Orally disintegrating dosage form for administration of avanafil, and associated methods of manufacture and use |
Also Published As
Publication number | Publication date |
---|---|
JP2005525353A (en) | 2005-08-25 |
AU2003208459A1 (en) | 2003-09-09 |
CA2476170A1 (en) | 2003-09-04 |
US20050169986A1 (en) | 2005-08-04 |
ZA200406193B (en) | 2005-10-06 |
GB0204771D0 (en) | 2002-04-17 |
EP1478346A1 (en) | 2004-11-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20050169986A1 (en) | Fast disintegrating tablets | |
US11013762B1 (en) | Pharmaceutical compositions | |
EP1058538B9 (en) | Fast disintegrating tablets | |
JP6092936B2 (en) | Method for producing orally disintegrating tablets | |
US10406105B2 (en) | Pharmaceutical formulation for the production of rapidly disintegrating tablets | |
US20060100214A1 (en) | Fast dissolving and taste masked oral dosage form comprising sildenafil | |
US20060099250A1 (en) | Use of an aqueous solution of citric acid and a water-soluble sugar like lactitol as granulation liquid in the manufacture of tablets | |
US20110081389A1 (en) | Composition comprising a mixture of active principles, and method of preparation | |
JP4802436B2 (en) | Orally disintegrating composition and orally disintegrating preparation | |
JP2005511589A (en) | Orally dispersible tablet having high homogeneity and method for preparing the same | |
EP1773292A1 (en) | Rapidly disintegrating orodispersible composition containing nonfilamentous coprocessed polyols particles and silicified microcrystalline cellulose | |
JP2004315483A (en) | Orally disintegrating tablet | |
WO2005120463A1 (en) | Rapidly disintegrating tablets of risperidone | |
JP2002255796A (en) | Rapidly disintegrating tablet in oral cavity and method for producing the same | |
EP1679066A1 (en) | Drug-containing coated microparticle for orally disintegrating tablet | |
JP5572321B2 (en) | Orally disintegrating tablets containing coated fine particles | |
JP2002029964A (en) | Solid medicine composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2003706747 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004/06193 Country of ref document: ZA Ref document number: 200406193 Country of ref document: ZA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2476170 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003570830 Country of ref document: JP Ref document number: 2003208459 Country of ref document: AU |
|
WWP | Wipo information: published in national office |
Ref document number: 2003706747 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10505916 Country of ref document: US |