WO2003072804A3 - Nanostructures containing pilin protein - Google Patents

Nanostructures containing pilin protein Download PDF

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Publication number
WO2003072804A3
WO2003072804A3 PCT/US2003/005340 US0305340W WO03072804A3 WO 2003072804 A3 WO2003072804 A3 WO 2003072804A3 US 0305340 W US0305340 W US 0305340W WO 03072804 A3 WO03072804 A3 WO 03072804A3
Authority
WO
WIPO (PCT)
Prior art keywords
joining
elements
nanostructure
assembly unit
binding
Prior art date
Application number
PCT/US2003/005340
Other languages
French (fr)
Other versions
WO2003072804A2 (en
Inventor
Lee Makowski
Original Assignee
Nanoframes Inc
Lee Makowski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanoframes Inc, Lee Makowski filed Critical Nanoframes Inc
Priority to AU2003217644A priority Critical patent/AU2003217644A1/en
Priority to JP2003571484A priority patent/JP2005518455A/en
Priority to KR10-2004-7013092A priority patent/KR20040094721A/en
Priority to CA002477271A priority patent/CA2477271A1/en
Priority to EP03713601A priority patent/EP1485129B1/en
Priority to DE60311076T priority patent/DE60311076D1/en
Publication of WO2003072804A2 publication Critical patent/WO2003072804A2/en
Publication of WO2003072804A3 publication Critical patent/WO2003072804A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • B82B3/0009—Forming specific nanostructures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor

Abstract

Nanostructures are made that include at least one species of assembly unit in which at least one joining element is a pilin protein or binding-derivative or binding-fragment thereof. The pilin-containing assembly units may have two pilin-derived joining elements, and may contain structural elements, functional elements or both. The nanostructure is suitably prepared using a staged assembly method, in which a nanostructure intermediate having at least one unbound joining element is contacted with an assembly unit having a plurality of different joining elements. None of the joining elements of the assembly unit can interact with itself or with another joining element of the same assembly unit. However, one of the joining elements can interact with the unbound joining element of the nanostructure intermediate, so that the assembly unit is non-covalently bound to the nanostructure intermediate. Unbound assembly units are removed and the cycles are repeated for a sufficient number of cycles to form a nanostructure. The complementary joining elements in at least one cycle include a pilin protein or a binding derivative or binding fragment thereof.
PCT/US2003/005340 2002-02-21 2003-02-21 Nanostructures containing pilin protein WO2003072804A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2003217644A AU2003217644A1 (en) 2002-02-21 2003-02-21 Nanostructures containing pilin protein
JP2003571484A JP2005518455A (en) 2002-02-21 2003-02-21 Nanostructures containing pilin proteins
KR10-2004-7013092A KR20040094721A (en) 2002-02-21 2003-02-21 Nanostructures containig pilin protein
CA002477271A CA2477271A1 (en) 2002-02-21 2003-02-21 Nanostructures containing pilin protein
EP03713601A EP1485129B1 (en) 2002-02-21 2003-02-21 Nanostructures containing pilin protein
DE60311076T DE60311076D1 (en) 2002-02-21 2003-02-21 NANOSTRUCTURES WITH PILIN PROTEIN

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/080,608 2002-02-21
US10/080,608 US20030198956A1 (en) 2002-02-21 2002-02-21 Staged assembly of nanostructures

Publications (2)

Publication Number Publication Date
WO2003072804A2 WO2003072804A2 (en) 2003-09-04
WO2003072804A3 true WO2003072804A3 (en) 2004-03-25

Family

ID=27765238

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2003/005339 WO2003072803A2 (en) 2002-02-21 2003-02-21 Nanostructures containing antibody assembly units
PCT/US2003/005340 WO2003072804A2 (en) 2002-02-21 2003-02-21 Nanostructures containing pilin protein
PCT/US2003/005390 WO2003072829A1 (en) 2002-02-21 2003-02-21 Nanostructures containing pna joining or functional elements

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2003/005339 WO2003072803A2 (en) 2002-02-21 2003-02-21 Nanostructures containing antibody assembly units

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2003/005390 WO2003072829A1 (en) 2002-02-21 2003-02-21 Nanostructures containing pna joining or functional elements

Country Status (8)

Country Link
US (2) US20030198956A1 (en)
EP (3) EP1485129B1 (en)
JP (3) JP2005518456A (en)
KR (3) KR20040102012A (en)
AU (3) AU2003217643A1 (en)
CA (3) CA2477171A1 (en)
DE (1) DE60311076D1 (en)
WO (3) WO2003072803A2 (en)

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Also Published As

Publication number Publication date
DE60311076D1 (en) 2007-02-22
EP1483408A4 (en) 2005-06-22
US20030198956A1 (en) 2003-10-23
EP1485128A2 (en) 2004-12-15
JP2005518454A (en) 2005-06-23
AU2003217644A1 (en) 2003-09-09
AU2003215377A1 (en) 2003-09-09
EP1485128A4 (en) 2006-08-30
KR20040102012A (en) 2004-12-03
KR20040094721A (en) 2004-11-10
WO2003072803A2 (en) 2003-09-04
WO2003072803A3 (en) 2004-02-19
JP2005518456A (en) 2005-06-23
CA2477171A1 (en) 2003-09-04
CA2477270A1 (en) 2003-09-04
CA2477271A1 (en) 2003-09-04
EP1485129B1 (en) 2007-01-10
JP2005518455A (en) 2005-06-23
WO2003072804A2 (en) 2003-09-04
KR20040102011A (en) 2004-12-03
US20030215903A1 (en) 2003-11-20
AU2003217643A1 (en) 2003-09-09
EP1483408A1 (en) 2004-12-08
EP1485129A4 (en) 2005-06-15
WO2003072829A1 (en) 2003-09-04
EP1485129A2 (en) 2004-12-15

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