WO2003077865A3 - Methods and compositions for directing cells to target organs - Google Patents
Methods and compositions for directing cells to target organs Download PDFInfo
- Publication number
- WO2003077865A3 WO2003077865A3 PCT/US2003/007836 US0307836W WO03077865A3 WO 2003077865 A3 WO2003077865 A3 WO 2003077865A3 US 0307836 W US0307836 W US 0307836W WO 03077865 A3 WO03077865 A3 WO 03077865A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- mammal
- compositions
- target organs
- directing cells
- Prior art date
Links
- 210000000056 organ Anatomy 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 3
- 210000001519 tissue Anatomy 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 210000001185 bone marrow Anatomy 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 210000003954 umbilical cord Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1741—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals alpha-Glycoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003225793A AU2003225793A1 (en) | 2002-03-15 | 2003-03-14 | Methods and compositions for directing cells to target organs |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36449802P | 2002-03-15 | 2002-03-15 | |
US60/364,498 | 2002-03-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003077865A2 WO2003077865A2 (en) | 2003-09-25 |
WO2003077865A3 true WO2003077865A3 (en) | 2004-04-01 |
Family
ID=28041926
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/007934 WO2003105908A2 (en) | 2002-03-15 | 2003-03-14 | Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs |
PCT/US2003/007836 WO2003077865A2 (en) | 2002-03-15 | 2003-03-14 | Methods and compositions for directing cells to target organs |
PCT/US2003/007834 WO2003077864A2 (en) | 2002-03-15 | 2003-03-14 | Methods and compositions for directing cells to target organs |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/007934 WO2003105908A2 (en) | 2002-03-15 | 2003-03-14 | Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/007834 WO2003077864A2 (en) | 2002-03-15 | 2003-03-14 | Methods and compositions for directing cells to target organs |
Country Status (10)
Country | Link |
---|---|
US (8) | US7282222B2 (en) |
EP (1) | EP1499347A2 (en) |
JP (1) | JP2006501169A (en) |
KR (1) | KR20050013531A (en) |
CN (1) | CN100579577C (en) |
AU (4) | AU2003267949A1 (en) |
CA (1) | CA2479309A1 (en) |
HK (1) | HK1079987A1 (en) |
IL (1) | IL164079A0 (en) |
WO (3) | WO2003105908A2 (en) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
CA2430989A1 (en) | 2000-12-06 | 2002-06-13 | Robert J. Hariri | Method of collecting placental stem cells |
EP2316919B1 (en) * | 2001-02-14 | 2015-10-07 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
WO2002063962A1 (en) * | 2001-02-14 | 2002-08-22 | Hariri Robert J | Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells |
AU2003267949A1 (en) * | 2002-03-15 | 2003-12-31 | U.S. Government As Represented By The Department Of Veterans Affairs | Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs |
US7576186B2 (en) * | 2002-04-23 | 2009-08-18 | Roger Williams Hospital | Compositions and methods for stem cell delivery |
US9321992B2 (en) * | 2002-06-14 | 2016-04-26 | Case Western Reserve University | Cell targeting methods and compositions |
US20050271639A1 (en) * | 2002-08-22 | 2005-12-08 | Penn Marc S | Genetically engineered cells for therapeutic applications |
CN1711475A (en) * | 2002-10-10 | 2005-12-21 | 退伍军人事务部 | Detection, localization and staging of tumors using labeled activated lymphocytes directed to a tumor specific epitope |
KR101042448B1 (en) | 2002-11-26 | 2011-06-16 | 안트로제네시스 코포레이션 | Cytotherapeutics, cytotherapeutic units and methods for treatments using them |
WO2004084950A2 (en) * | 2003-03-24 | 2004-10-07 | Case Western Reserve University | Cell targeting methods and compositions |
US8603462B2 (en) | 2003-04-01 | 2013-12-10 | University Of Utah Research Foundation | Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction |
EP2298861B1 (en) | 2004-03-22 | 2017-09-13 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
JP2008515434A (en) * | 2004-10-08 | 2008-05-15 | ジョージア テック リサーチ コーポレイション | Microencapsulation of cells in hydrogels using electrostatic potential |
FI20055398A0 (en) | 2005-07-08 | 2005-07-08 | Suomen Punainen Risti Veripalv | Method for evaluating cell populations |
NZ597304A (en) | 2005-10-13 | 2013-06-28 | Anthrogenesis Corp | Immunomodulation using placental stem cells |
AU2006332679A1 (en) | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
JP5550235B2 (en) | 2005-12-29 | 2014-07-16 | アントフロゲネシス コーポレーション | Placental stem cell population |
US20070178073A1 (en) * | 2006-02-01 | 2007-08-02 | Samsung Life Public Welfare Foundation | Composition Comprising Separated or Proliferated Cells from Umbilical Cord Blood for Treating Developmental and/or Chronic Lung Disease |
EP2422794A3 (en) | 2006-03-07 | 2013-03-13 | Geeta Shroff | Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation |
US7959949B2 (en) | 2006-04-27 | 2011-06-14 | University Of Central Florida Research Foundation, Inc. | Functionalized nanoceria composition for ophthalmic treatment |
WO2008073748A1 (en) * | 2006-12-08 | 2008-06-19 | University Of Rochester | Expansion of hematopoietic stem cells |
CA2672998C (en) | 2007-01-02 | 2013-08-06 | University Of Central Florida Research Foundation, Inc. | Methods and materials for stimulating proliferation of stem cells |
FI20075030A0 (en) | 2007-01-18 | 2007-01-18 | Suomen Punainen Risti Veripalv | Method of modifying cells |
US20090104160A1 (en) * | 2007-02-01 | 2009-04-23 | Moraga Biotechnology Corporation | Mobilization of Stem Cells After Trauma and Methods Therefor |
CN103356711A (en) | 2007-02-12 | 2013-10-23 | 人类起源公司 | Immunomodulation using placental stem cells |
EP2142206B1 (en) | 2007-03-30 | 2014-07-30 | The Cleveland Clinic Foundation | SDF-1 for use in the treatment of ischemic peripheral vascular disorders |
US8574567B2 (en) | 2007-05-03 | 2013-11-05 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
EP2155860B1 (en) | 2007-05-03 | 2014-08-27 | The Brigham and Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
US9119391B1 (en) | 2007-07-16 | 2015-09-01 | University Of Central Florida Research Foundation, Inc. | Polymer coated ceria nanoparticles for selective cytoprotection |
WO2009037690A1 (en) * | 2007-09-19 | 2009-03-26 | Pluristem Ltd. | Adherent cells from adipose or placenta tissues and use thereof in therapy |
AU2008307633C1 (en) | 2007-09-28 | 2015-04-30 | Celularity Inc. | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
US8142759B2 (en) * | 2007-12-12 | 2012-03-27 | Institute Of Nuclear Energy Research | Glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent thereof |
CA2709398C (en) | 2007-12-14 | 2017-11-07 | The Cleveland Clinic Foundation | Use of stromal cell-derived factor 1 for promoting wound healing |
US20090246179A1 (en) * | 2008-02-11 | 2009-10-01 | The Cleveland Clinic Foundation | Method of treating myocardial injury |
WO2009132277A1 (en) * | 2008-04-25 | 2009-10-29 | The Board Of Regents Of The University Of Oklahoma | Inhibition of neovascularization by cerium oxide nanoparticles |
US8916199B1 (en) | 2008-04-25 | 2014-12-23 | University of Central Florida Research Foundation, Ind. | Inhibition of angiogenesis associated with ovarian cancer by nanoparticles of cerium oxide |
EP2166085A1 (en) | 2008-07-16 | 2010-03-24 | Suomen Punainen Risti Veripalvelu | Divalent modified cells |
US9127202B1 (en) | 2008-07-18 | 2015-09-08 | University Of Central Florida Research Foundation, Inc. | Biocompatible nano rare earth oxide upconverters for imaging and therapeutics |
KR20180108887A (en) | 2008-08-20 | 2018-10-04 | 안트로제네시스 코포레이션 | Treatment of stroke using isolated placental cells |
JP6169316B2 (en) | 2008-08-20 | 2017-07-26 | アンスロジェネシス コーポレーション | Improved cell composition and method for producing the same |
MX2011001992A (en) | 2008-08-22 | 2011-03-29 | Anthrogenesis Corp | Methods and compositions for treatment of bone defects with placental cell populations. |
SG190659A1 (en) | 2008-09-02 | 2013-06-28 | Pluristem Ltd | Adherent cells from placenta tissue and use thereof in therapy |
RU2562154C2 (en) | 2008-11-19 | 2015-09-10 | Антродженезис Корпорейшн | Amniotic adhesive cells |
US10328103B2 (en) | 2009-01-03 | 2019-06-25 | Ray C. Wasielewski | Medical treatment composition comprising mammalian dental pulp stem cells |
US8470308B2 (en) * | 2009-01-03 | 2013-06-25 | Ray C. Wasielewski | Enhanced medical implant comprising disrupted tooth pulp and tooth particles |
US8883519B1 (en) | 2009-03-17 | 2014-11-11 | University Of Central Florida Research Foundation, Inc. | Oxidase activity of polymeric coated cerium oxide nanoparticles |
US9585840B1 (en) | 2009-07-10 | 2017-03-07 | University Of Central Florida Research Foundation, Inc. | Redox active cerium oxide nanoparticles and associated methods |
JP5856059B2 (en) | 2009-08-28 | 2016-02-09 | ザ クリーブランド クリニック ファウンデーション | SDF-1 delivery for treating ischemic tissue |
US8795731B1 (en) | 2009-10-12 | 2014-08-05 | University Of Central Florida Research Foundation, Inc. | Cerium oxide nanoparticle-based device for the detection of reactive oxygen species and monitoring of chronic inflammation |
ES2646750T3 (en) | 2010-01-26 | 2017-12-15 | Anthrogenesis Corporation | Treatment of bone-related cancers using placental stem cells |
WO2011102890A1 (en) * | 2010-02-18 | 2011-08-25 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treatment of hemophilia |
KR20190076060A (en) | 2010-04-07 | 2019-07-01 | 안트로제네시스 코포레이션 | Angiogenesis using placental stem cells |
EP2555783A1 (en) | 2010-04-08 | 2013-02-13 | Anthrogenesis Corporation | Treatment of sarcoidosis using placental stem cells |
US20130156773A1 (en) * | 2010-06-18 | 2013-06-20 | Women And Infants Hospital Of Rhode Island | Lung regeneration using cord blood-derived hematopoietic stem cells |
WO2012009422A1 (en) | 2010-07-13 | 2012-01-19 | Anthrogenesis Corporation | Methods of generating natural killer cells |
US10426740B1 (en) | 2010-08-18 | 2019-10-01 | Avm Biotechnology, Llc | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
US8877207B2 (en) | 2010-09-17 | 2014-11-04 | University Of Central Florida Research Foundation, Inc. | Nanoparticles of cerium oxide targeted to an amyloid-beta antigen of Alzheimer's disease and associated methods |
US8969315B2 (en) | 2010-12-31 | 2015-03-03 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory RNA molecules |
WO2012127320A1 (en) | 2011-03-22 | 2012-09-27 | Pluristem Ltd. | Methods for treating radiation or chemical injury |
ES2707579T3 (en) | 2011-06-01 | 2019-04-04 | Celularity Inc | Pain treatment using placental cytoblast |
US8951539B1 (en) | 2011-06-07 | 2015-02-10 | University Of Central Florida Research Foundation, Inc. | Methods of promoting angiogenesis using cerium oxide nanoparticles |
WO2013055476A1 (en) | 2011-09-09 | 2013-04-18 | Anthrogenesis Corporation | Treatment of amyotrophic lateral sclerosis using placental stem cells |
US9161950B2 (en) | 2011-09-21 | 2015-10-20 | University Of Central Florida Foundation, Inc. | Neuronal protection by cerium oxide nanoparticles |
AU2014215458A1 (en) | 2013-02-05 | 2015-08-13 | Anthrogenesis Corporation | Natural killer cells from placenta |
US9463437B2 (en) | 2013-02-14 | 2016-10-11 | University Of Central Florida Research Foundation, Inc. | Methods for scavenging nitric oxide using cerium oxide nanoparticles |
WO2015172659A1 (en) * | 2014-05-14 | 2015-11-19 | 中国科学院上海生命科学研究院 | Uses of il-17 in enhancing immune-suppression function of mesenchymal stem cells |
WO2016057649A1 (en) * | 2014-10-07 | 2016-04-14 | NuTech Medical, Inc. | Mesenchymal stem cell diagnostic testing |
JP2018535655A (en) | 2015-09-29 | 2018-12-06 | アムジエン・インコーポレーテツド | ASGR inhibitor |
GB201604304D0 (en) | 2016-03-14 | 2016-04-27 | Tigenix S A U | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
MX2019011679A (en) | 2017-04-01 | 2019-11-01 | Avm Biotechnology Llc | Replacement of cytotoxic preconditioning before cellular immunotherapy. |
EP3488851A1 (en) | 2018-10-03 | 2019-05-29 | AVM Biotechnology, LLC | Immunoablative therapies |
WO2020142727A1 (en) * | 2019-01-03 | 2020-07-09 | Palleon Pharmaceuticals Inc. | Methods and compositions for treating cancer with immune cells |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4466951A (en) * | 1982-11-12 | 1984-08-21 | University Of California | Intracellular trapping of therapeutics or tracer agents |
JPS61503003A (en) * | 1984-04-19 | 1986-12-25 | ユニバ−シテイ− オブ クイ−ンスランド | Contraceptive methods, contraceptive preparations and contraceptive devices |
US4797368A (en) * | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US5776093A (en) * | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
US4735210A (en) * | 1985-07-05 | 1988-04-05 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
US4801533A (en) * | 1986-06-25 | 1989-01-31 | Fudenberg H Hugh | Method of using alpha-1 acid glycoprotein on T-cells as a marker for alzheimer's disease |
US5284646A (en) * | 1986-07-03 | 1994-02-08 | Advanced Magnetics Inc. | Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents |
US5352432A (en) * | 1986-07-03 | 1994-10-04 | Advanced Magnetics, Inc. | Hepatocyte specific composition and their use as diagnostic imaging agents |
US5679323A (en) | 1986-07-03 | 1997-10-21 | Advanced Magnetics, Inc. | Hepatocyte-specific receptor-mediated endocytosis-type compositions |
US5262176A (en) * | 1986-07-03 | 1993-11-16 | Advanced Magnetics, Inc. | Synthesis of polysaccharide covered superparamagnetic oxide colloids |
US5554386A (en) * | 1986-07-03 | 1996-09-10 | Advanced Magnetics, Inc. | Delivery of therapeutic agents to receptors using polysaccharides |
US5342607A (en) * | 1986-07-03 | 1994-08-30 | Advanced Magnetics, Inc. | Receptor mediated endocytosis type magnetic resonance imaging contrast agents |
US5490991A (en) * | 1986-07-03 | 1996-02-13 | Advanced Magnetics, Inc. | Directed delivery of radioprotectants using a receptor specific carrier |
EP0273452B1 (en) | 1986-12-30 | 1994-03-23 | Nihon Medi-Physics Co., Ltd. | High molecular compound comprising unit of asialoglycoprotein acceptor-directing compound and unit of chelate-forming compound chemically bonded thereto, and its utilisation |
US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
US5098843A (en) * | 1987-06-04 | 1992-03-24 | Calvin Noel M | Apparatus for the high efficiency transformation of living cells |
US5270199A (en) * | 1987-08-20 | 1993-12-14 | The Children's Medical Center Corporation | Human mannose-binding protein |
US5128257A (en) * | 1987-08-31 | 1992-07-07 | Baer Bradford W | Electroporation apparatus and process |
US4859449A (en) * | 1987-09-14 | 1989-08-22 | Center For Molecular Medicine And Immunology | Modified antibodies for enhanced hepatocyte clearance |
US4970154A (en) * | 1987-10-09 | 1990-11-13 | Baylor College Of Medicine | Method for inserting foreign genes into cells using pulsed radiofrequency |
US5043260A (en) | 1987-11-02 | 1991-08-27 | Rhode Island Hospital | Perfusion device with hepatocytes |
US5057301A (en) * | 1988-04-06 | 1991-10-15 | Neorx Corporation | Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents |
US5399346A (en) * | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
DK0452457T3 (en) | 1989-11-03 | 1998-03-02 | Univ Vanderbilt | Method for in vivo removal of functional foreign genes |
US5279833A (en) * | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
US5460831A (en) * | 1990-06-22 | 1995-10-24 | The Regents Of The University Of California | Targeted transfection nanoparticles |
US5173414A (en) * | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
US5837539A (en) * | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
ZA922265B (en) * | 1991-03-28 | 1992-12-30 | American Cyanamid Co | Somatostatin receptor |
US5352670A (en) * | 1991-06-10 | 1994-10-04 | Alberta Research Council | Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides |
KR950014915B1 (en) * | 1991-06-19 | 1995-12-18 | 주식회사녹십자 | Asialoglycoprotein-conjugated compounds |
US5254342A (en) * | 1991-09-30 | 1993-10-19 | University Of Southern California | Compositions and methods for enhanced transepithelial and transendothelial transport or active agents |
NZ244306A (en) * | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
US5545130A (en) * | 1992-04-08 | 1996-08-13 | Genetronics, Inc. | Flow through electroporation method |
US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
IL105914A0 (en) | 1992-06-04 | 1993-10-20 | Univ California | Methods and compositions for in vivo gene therapy |
US5624896A (en) * | 1992-06-09 | 1997-04-29 | Neorx Corporation | Clearing agents useful in pretargeting methods |
US5608060A (en) | 1992-06-09 | 1997-03-04 | Neorx Corporation | Biotinidase-resistant biotin-DOTA conjugates |
US5616690A (en) * | 1992-06-09 | 1997-04-01 | Neorx Corporation | Hexose derivatized human serum albumin clearing agents |
US5322682A (en) * | 1992-08-06 | 1994-06-21 | The Regents Of The University Of California | Method for quantitatively measuring and mapping stored iron in tissue using MRI |
US5656609A (en) * | 1992-09-24 | 1997-08-12 | University Of Connecticut | Method of enhancing and/or prolonging expression of gene introduced into a cell using colchicine |
ATE244888T1 (en) * | 1993-02-05 | 2003-07-15 | Epigen Inc | HUMAN CARCINOMA ANTIGEN (HCA), HCA ANTIBODIES, HCA IMMUNOASSAYS, RECORDING METHODS AND THERAPY |
US5670361A (en) | 1993-05-17 | 1997-09-23 | The Regents Of The University Of California | HIV-specific ribozymes |
US5525503A (en) * | 1993-09-28 | 1996-06-11 | Dana-Farber Cancer Institute, Inc. | Signal transduction via CD28 |
US5527884A (en) * | 1993-12-21 | 1996-06-18 | President And Fellows Of Harvard College | Mediators of chronic allograft rejection and DNA molecules encoding them |
US5728518A (en) * | 1994-01-12 | 1998-03-17 | The Immune Response Corporation | Antiviral poly-and oligonucleotides |
US5728399A (en) | 1994-06-29 | 1998-03-17 | University Of Conn. | Use of a bacterial component to enhance targeted delivery of polynucleotides to cells |
US5512294A (en) * | 1994-08-05 | 1996-04-30 | Li; King C. | Targeted polymerized liposome contrast agents |
US5683866A (en) * | 1996-05-09 | 1997-11-04 | Sarkar; Debi P. | Process for producing a targeted gene |
US6146614A (en) * | 1996-07-02 | 2000-11-14 | Massachusetts Institute Of Technology | Method for determining lymphocyte distribution and trafficking in mammals using imaging |
US5719020A (en) | 1996-09-25 | 1998-02-17 | Oklahoma Medical Research Foundation | 4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens |
US7282220B1 (en) * | 1996-11-05 | 2007-10-16 | Hsing-Wen Sung | Genipin-crosslinked gelatin microspheres as drug carrier |
DE69842060D1 (en) | 1997-05-08 | 2011-01-27 | Oncothyreon Inc | Method of obtaining activated T cells and antigen-incubated antigen-presenting cells |
US6466599B1 (en) * | 1999-04-07 | 2002-10-15 | Lambda Physik Ag | Discharge unit for a high repetition rate excimer or molecular fluorine laser |
AU3923000A (en) * | 1999-04-16 | 2000-11-02 | Amgen, Inc. | Agp-1 fusion protein compositions and methods |
US6406699B1 (en) * | 1999-10-05 | 2002-06-18 | Gary W. Wood | Composition and method of cancer antigen immunotherapy |
AU2003267949A1 (en) | 2002-03-15 | 2003-12-31 | U.S. Government As Represented By The Department Of Veterans Affairs | Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs |
CN1711475A (en) * | 2002-10-10 | 2005-12-21 | 退伍军人事务部 | Detection, localization and staging of tumors using labeled activated lymphocytes directed to a tumor specific epitope |
-
2003
- 2003-03-14 AU AU2003267949A patent/AU2003267949A1/en not_active Abandoned
- 2003-03-14 JP JP2004512808A patent/JP2006501169A/en active Pending
- 2003-03-14 US US10/388,964 patent/US7282222B2/en not_active Expired - Lifetime
- 2003-03-14 WO PCT/US2003/007934 patent/WO2003105908A2/en active Application Filing
- 2003-03-14 KR KR10-2004-7014544A patent/KR20050013531A/en not_active Application Discontinuation
- 2003-03-14 AU AU2003225793A patent/AU2003225793A1/en not_active Abandoned
- 2003-03-14 WO PCT/US2003/007836 patent/WO2003077865A2/en not_active Application Discontinuation
- 2003-03-14 IL IL16407903A patent/IL164079A0/en unknown
- 2003-03-14 WO PCT/US2003/007834 patent/WO2003077864A2/en not_active Application Discontinuation
- 2003-03-14 CN CN03809426A patent/CN100579577C/en not_active Expired - Fee Related
- 2003-03-14 CA CA002479309A patent/CA2479309A1/en not_active Abandoned
- 2003-03-14 AU AU2003225791A patent/AU2003225791A1/en not_active Abandoned
- 2003-03-14 EP EP03748896A patent/EP1499347A2/en not_active Withdrawn
-
2005
- 2005-02-01 US US10/940,691 patent/US20070110734A9/en not_active Abandoned
-
2006
- 2006-01-04 HK HK06100051.0A patent/HK1079987A1/en unknown
-
2007
- 2007-04-20 US US11/788,578 patent/US20070243174A1/en not_active Abandoned
- 2007-04-20 US US11/788,636 patent/US20070196331A1/en not_active Abandoned
- 2007-04-20 US US11/788,643 patent/US7563459B2/en not_active Expired - Lifetime
- 2007-04-20 US US11/788,577 patent/US20070243173A1/en not_active Abandoned
- 2007-04-20 US US11/788,645 patent/US20070248577A1/en not_active Abandoned
-
2009
- 2009-05-06 AU AU2009201808A patent/AU2009201808A1/en not_active Abandoned
- 2009-10-30 US US12/610,183 patent/US20100047215A1/en not_active Abandoned
Non-Patent Citations (4)
Title |
---|
HAMANO T. ET AL.: "Studies on the kinetics of hemopoietic stem cells and immune response to the Hapten-Carrier conjugate", THE JOURNAL OF IMMUNOLOGY, vol. 123, no. 3, September 1979 (1979-09-01), pages 1371 - 1375, XP002973618 * |
NOMURA ET AL.: "Targeted gene delivery to the hepatocytes by asialoglycoprotein receptor-mediated endocytosis", ENVIRONMENTAL MEDICINE, vol. 39, no. 1, 1995, pages 17 - 20, XP002973620 * |
PEREIRA R. ET AL.: "Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage and lung in irradiated mice", PROC. NATL. ACAD. SCI. USA, vol. 92, May 1995 (1995-05-01), pages 4857 - 4861, XP002139789 * |
TERANISHI K. ET AL.: "Depletion of anti-gal antibodies in baboons by intravenous therapy with bovine serum albumin conjugated to gal oligosaccharides", TRANSPLANTATION, vol. 73, 15 January 2002 (2002-01-15), pages 129 - 139, XP002973619 * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2003077865A3 (en) | Methods and compositions for directing cells to target organs | |
NO20035637D0 (en) | Carbon monoxide improves the results of tissue and organ transplants and suppresses apoptosis | |
WO2001078754A3 (en) | Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof | |
WO2004098535A3 (en) | Modified antibodies to prostate-specific membrane antigen and uses thereof | |
WO2007064846A3 (en) | COMPOSITIONS AND METHODS OF USING siRNA TO KNOCKDOWN GENE EXPRESSION AND TO IMPROVE SOLID ORGAN AND CELL TRANSPLANTATION | |
WO2004101758A3 (en) | Composition for maintaining organ and cell viability | |
WO2002098897A3 (en) | Modified antibodies to prostate-specific membrane antigen and uses thereof | |
WO2003105757A3 (en) | Methods and compositions for milieu-dependent binding of a targeted agent to a target | |
WO1999046366A8 (en) | Uses for humane non-autologous mesenchymal stem cells | |
IL206293A0 (en) | Genetically engineered duckweed | |
EP1638460A4 (en) | Directing cells to target tissues or organs | |
WO2007016501A3 (en) | Compositions and method for brain specific targeted delivery of therapeutic agents | |
WO2006074012A3 (en) | Facilitated cellular reconstitution of organs and tissues | |
AU2002331356A1 (en) | Nanoparticles for dna administration to a target organ | |
WO2004006833A3 (en) | Bowel cleansing composition | |
WO2001068828A3 (en) | Compositions and methods for regulated protein expression in gut | |
GB2415698A (en) | Transformation of brassica | |
WO2005001044A3 (en) | Compositions related to pleiotrophin methods and uses thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: JP |