WO2003084520A3 - Pharmaceutical preparation containing oxycodone and naloxone - Google Patents

Pharmaceutical preparation containing oxycodone and naloxone Download PDF

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Publication number
WO2003084520A3
WO2003084520A3 PCT/EP2003/003540 EP0303540W WO03084520A3 WO 2003084520 A3 WO2003084520 A3 WO 2003084520A3 EP 0303540 W EP0303540 W EP 0303540W WO 03084520 A3 WO03084520 A3 WO 03084520A3
Authority
WO
WIPO (PCT)
Prior art keywords
naloxone
pharmaceutical preparation
preparation containing
containing oxycodone
oxycodone
Prior art date
Application number
PCT/EP2003/003540
Other languages
French (fr)
Other versions
WO2003084520A2 (en
Inventor
Bianca Broegmann
Silke Muehlau
Christof Spitzley
Original Assignee
Euro Celtique Sa
Bianca Broegmann
Silke Muehlau
Christof Spitzley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=28676052&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003084520(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE10215131A external-priority patent/DE10215131A1/en
Priority claimed from DE10215067A external-priority patent/DE10215067A1/en
Priority to MXPA04009713A priority Critical patent/MXPA04009713A/en
Priority to APAP/P/2004/003137A priority patent/AP2043A/en
Priority to SI200332440T priority patent/SI1492505T1/en
Priority to JP2003581760A priority patent/JP4755810B2/en
Priority to DE20308437U priority patent/DE20308437U1/en
Priority to AU2003224040A priority patent/AU2003224040B2/en
Priority to BRPI0309544A priority patent/BRPI0309544B8/en
Priority to KR10-2004-7015828A priority patent/KR20040098050A/en
Priority to EP03720424.5A priority patent/EP1492505B1/en
Priority to CN038077965A priority patent/CN1646102B/en
Priority to ES03720424.5T priority patent/ES2546010T3/en
Priority to DK03720424.5T priority patent/DK1492505T3/en
Priority to US10/510,674 priority patent/US20050245556A1/en
Application filed by Euro Celtique Sa, Bianca Broegmann, Silke Muehlau, Christof Spitzley filed Critical Euro Celtique Sa
Priority to IL16399003A priority patent/IL163990A0/en
Priority to CA2478515A priority patent/CA2478515C/en
Publication of WO2003084520A2 publication Critical patent/WO2003084520A2/en
Publication of WO2003084520A3 publication Critical patent/WO2003084520A3/en
Priority to IL163990A priority patent/IL163990A/en
Priority to ZA2004/07267A priority patent/ZA200407267B/en
Priority to TNP2004000192A priority patent/TNSN04192A1/en
Priority to HK05105025.3A priority patent/HK1072367A1/en
Priority to IL182742A priority patent/IL182742A0/en
Priority to FI20070322U priority patent/FI7846U1/en
Priority to IL200621A priority patent/IL200621A/en
Priority to US13/251,172 priority patent/US20120108621A1/en
Priority to US14/058,068 priority patent/US20140045877A1/en
Priority to US14/305,785 priority patent/US9555000B2/en
Priority to US15/399,487 priority patent/US9907793B2/en
Priority to US15/881,459 priority patent/US10420762B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention concerns a storage stable pharmaceutical preparation comprising oxycodone and naloxone for use in pain therapy, with the active compounds being released from the preparation in a sustained, invariant and independent manner.
PCT/EP2003/003540 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone WO2003084520A2 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
KR10-2004-7015828A KR20040098050A (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone
CA2478515A CA2478515C (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone
IL16399003A IL163990A0 (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone
CN038077965A CN1646102B (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone
SI200332440T SI1492505T1 (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone
JP2003581760A JP4755810B2 (en) 2002-04-05 2003-04-04 Pharmaceutical formulation containing oxycodone and naloxone
DE20308437U DE20308437U1 (en) 2002-04-05 2003-04-04 Matrix for delayed, consistent and independent release of drugs
AU2003224040A AU2003224040B2 (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone
BRPI0309544A BRPI0309544B8 (en) 2002-04-05 2003-04-04 storage stable oral pharmaceutical preparation comprising oxycodone and naloxone
MXPA04009713A MXPA04009713A (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone.
EP03720424.5A EP1492505B1 (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone
APAP/P/2004/003137A AP2043A (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone
ES03720424.5T ES2546010T3 (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone
DK03720424.5T DK1492505T3 (en) 2002-04-05 2003-04-04 PHARMACEUTICAL PREPARATION CONTAINING OXYCODON AND NALOXON
US10/510,674 US20050245556A1 (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone
IL163990A IL163990A (en) 2002-04-05 2004-09-09 Storage stable pharmaceuitcal preparation containing oxycodone and naloxone with sustained, invariant and independent release
ZA2004/07267A ZA200407267B (en) 2002-04-05 2004-09-10 Pharmaceutical preparation containing oxycodone and naloxone
TNP2004000192A TNSN04192A1 (en) 2002-04-05 2004-10-04 PHARMACEUTICAL PREPARATION CONTAINING OXYCODONE AND NALOXONE
HK05105025.3A HK1072367A1 (en) 2002-04-05 2005-06-15 Pharmaceutical preparation containing oxycodone and naloxone
IL182742A IL182742A0 (en) 2002-04-05 2007-04-23
FI20070322U FI7846U1 (en) 2002-04-05 2007-08-17 Pharmaceutical preparation containing oxycodone and naloxone
IL200621A IL200621A (en) 2002-04-05 2009-08-27 Method of producing an oral pharmaceutical preparation in sustained release matrix comprising oxycodone and naloxone by granulation or extrusion
US13/251,172 US20120108621A1 (en) 2002-04-05 2011-09-30 Pharmaceutical preparation containing oxycodone and naloxone
US14/058,068 US20140045877A1 (en) 2002-04-05 2013-10-18 Pharmaceutical preparation containing oxycodone and naloxone
US14/305,785 US9555000B2 (en) 2002-04-05 2014-06-16 Pharmaceutical preparation containing oxycodone and naloxone
US15/399,487 US9907793B2 (en) 2002-04-05 2017-01-05 Pharmaceutical preparation containing oxycodone and naloxone
US15/881,459 US10420762B2 (en) 2002-04-05 2018-01-26 Pharmaceutical preparation containing oxycodone and naloxone

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10215131.8 2002-04-05
DE10215131A DE10215131A1 (en) 2002-04-05 2002-04-05 Stable pharmaceutical preparation useful for the treatment of pain, especially severe pain, without causing side-effects comprises oxycodone and naxolone in retarded release formulation
DE10215067.2 2002-04-05
DE10215067A DE10215067A1 (en) 2002-04-05 2002-04-05 Stable pharmaceutical preparation useful for the treatment of pain, especially severe pain, without causing side-effects comprises oxycodone and naxolone in retarded release formulation

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10510674 A-371-Of-International 2003-04-04
US10/510,674 A-371-Of-International US20050245556A1 (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone
US13/251,172 Continuation US20120108621A1 (en) 2002-04-05 2011-09-30 Pharmaceutical preparation containing oxycodone and naloxone

Publications (2)

Publication Number Publication Date
WO2003084520A2 WO2003084520A2 (en) 2003-10-16
WO2003084520A3 true WO2003084520A3 (en) 2004-03-11

Family

ID=28676052

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2003/003541 WO2003084504A2 (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds
PCT/EP2003/003540 WO2003084520A2 (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/003541 WO2003084504A2 (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds

Country Status (33)

Country Link
US (11) US20050245483A1 (en)
EP (17) EP2425824B1 (en)
JP (5) JP4620355B2 (en)
KR (3) KR100784341B1 (en)
CN (4) CN102813654A (en)
AP (2) AP2043A (en)
AR (3) AR039378A1 (en)
AT (1) ATE418967T2 (en)
AU (2) AU2003224041B2 (en)
BR (2) BRPI0309544B8 (en)
CA (3) CA2478515C (en)
CO (2) CO5611100A2 (en)
CY (5) CY1108914T1 (en)
DE (6) DE20308437U1 (en)
DK (6) DK2425825T3 (en)
ES (7) ES2546010T3 (en)
FI (1) FI7846U1 (en)
GE (3) GEP20084485B (en)
HK (5) HK1072367A1 (en)
HU (4) HUE032529T2 (en)
IL (5) IL163990A0 (en)
LT (3) LT2425824T (en)
MA (2) MA27249A1 (en)
MX (2) MXPA04009713A (en)
NZ (1) NZ535286A (en)
PH (1) PH12018000176A1 (en)
PT (5) PT2425825T (en)
RU (3) RU2297225C2 (en)
SI (5) SI2425821T1 (en)
TN (1) TNSN04192A1 (en)
TW (3) TWI337077B (en)
WO (2) WO2003084504A2 (en)
ZA (2) ZA200407267B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846091B2 (en) 2002-04-05 2014-09-30 Euro-Celtique S.A. Matrix for sustained, invariant and independent release of active compounds
US8932630B1 (en) 1997-12-22 2015-01-13 Purdue Pharma L.P Opioid agonist/antagonist combinations
US8936808B1 (en) 1997-12-22 2015-01-20 Purdue Pharma L.P. Opioid agonist/opioid antagonist/acetaminophen combinations
US9271940B2 (en) 2009-03-10 2016-03-01 Purdue Pharma L.P. Immediate release pharmaceutical compositions comprising oxycodone and naloxone

Families Citing this family (135)

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EP2295043A1 (en) 1999-10-29 2011-03-16 Euro-Celtique S.A. Controlled release hydrocodone formulations
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
JP2003522144A (en) 2000-02-08 2003-07-22 ユーロ−セルティーク，エス．エイ． Controlled release compositions comprising opioid agonists and antagonists
AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
CN101317825A (en) 2000-10-30 2008-12-10 欧罗赛铁克股份有限公司 Controlled release hydrocodone formulations
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
CN1525851A (en) 2001-05-11 2004-09-01 ������ҩ�����޹�˾ Abuse-resistant controlled-release opioid dosage form
SI1416842T1 (en) 2001-07-18 2009-06-30 Euro Celtique Sa Pharmaceutical combinations of oxycodone and naloxone
ES2326794T3 (en) 2001-08-06 2009-10-20 Euro-Celtique S.A. FORMULATIONS OF OPIOID AGONISTS WITH LIBERABLE AND SEQUESTED ANTAGONISTS.
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
PA8578501A1 (en) 2002-07-25 2005-02-04 Pharmacia Corp DOSAGE FORM ONCE A DAY OF PRAMIPEXOL
MY135852A (en) 2003-04-21 2008-07-31 Euro Celtique Sa Pharmaceutical products
DE102005005446A1 (en) 2005-02-04 2006-08-10 Grünenthal GmbH Break-resistant dosage forms with sustained release
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10336400A1 (en) 2003-08-06 2005-03-24 Grünenthal GmbH Anti-abuse dosage form
DE10361596A1 (en) 2003-12-24 2005-09-29 Grünenthal GmbH Process for producing an anti-abuse dosage form
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US20060194826A1 (en) * 2003-09-25 2006-08-31 Euro-Celtique S.A. Pharmaceutical combinations of hydrocodone and naltrexone
GB0501638D0 (en) * 2005-01-28 2005-03-02 Euro Celtique Sa Particulates
TWI350762B (en) * 2004-02-12 2011-10-21 Euro Celtique Sa Particulates
GB0403098D0 (en) 2004-02-12 2004-03-17 Euro Celtique Sa Extrusion
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US9555000B2 (en) 2002-04-05 2017-01-31 Purdue Pharma L.P. Pharmaceutical preparation containing oxycodone and naloxone
US9271940B2 (en) 2009-03-10 2016-03-01 Purdue Pharma L.P. Immediate release pharmaceutical compositions comprising oxycodone and naloxone

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