WO2003088905A3 - Compositions and minimally invasive methods for treating incomplete tissue repair - Google Patents
Compositions and minimally invasive methods for treating incomplete tissue repair Download PDFInfo
- Publication number
- WO2003088905A3 WO2003088905A3 PCT/US2003/011623 US0311623W WO03088905A3 WO 2003088905 A3 WO2003088905 A3 WO 2003088905A3 US 0311623 W US0311623 W US 0311623W WO 03088905 A3 WO03088905 A3 WO 03088905A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compositions
- minimally invasive
- tissue repair
- invasive methods
- incomplete tissue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03718407.4A EP1494535B1 (en) | 2002-04-13 | 2003-04-14 | Compositions and minimally invasive methods for treating incomplete tissue repair |
AU2003221946A AU2003221946B2 (en) | 2002-04-13 | 2003-04-14 | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
JP2003585658A JP4493346B2 (en) | 2002-04-13 | 2003-04-14 | Compositions and minimally invasive methods for treating incomplete tissue repair |
ES03718407.4T ES2613378T3 (en) | 2002-04-13 | 2003-04-14 | Minimally invasive compositions and methods to treat incomplete tissue repair |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37268202P | 2002-04-13 | 2002-04-13 | |
US60/372,682 | 2002-04-13 | ||
US10/412,821 US6811777B2 (en) | 2002-04-13 | 2003-04-11 | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
US10/412,821 | 2003-04-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003088905A2 WO2003088905A2 (en) | 2003-10-30 |
WO2003088905A3 true WO2003088905A3 (en) | 2004-08-26 |
Family
ID=28794492
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/011623 WO2003088905A2 (en) | 2002-04-13 | 2003-04-14 | Compositions and minimally invasive methods for treating incomplete tissue repair |
Country Status (7)
Country | Link |
---|---|
US (10) | US6811777B2 (en) |
EP (2) | EP1494535B1 (en) |
JP (2) | JP4493346B2 (en) |
KR (1) | KR101019188B1 (en) |
AU (1) | AU2003221946B2 (en) |
ES (1) | ES2613378T3 (en) |
WO (1) | WO2003088905A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8992862B2 (en) | 2009-04-03 | 2015-03-31 | Biomet Biologics, Llc | All-in-one means of separating blood components |
US9114334B2 (en) | 2002-05-24 | 2015-08-25 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6979307B2 (en) | 1997-06-24 | 2005-12-27 | Cascade Medical Enterprises Llc | Systems and methods for preparing autologous fibrin glue |
US7745106B2 (en) * | 1997-06-24 | 2010-06-29 | Cascade Medical Enterprises, Llc | Methods and devices for separating liquid components |
US7431922B2 (en) * | 2002-03-29 | 2008-10-07 | Tissuegene, Inc. | Bioadhesive directed somatic cell therapy |
US7608258B2 (en) * | 2002-04-13 | 2009-10-27 | Allan Mishra | Method for treatment of tendinosis using platelet rich plasma |
US6811777B2 (en) * | 2002-04-13 | 2004-11-02 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
AU2003249642A1 (en) | 2002-05-24 | 2003-12-12 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
AR047712A1 (en) * | 2002-09-07 | 2006-02-15 | Royal Veterinary College | TREATMENT METHOD OF A NATURAL SOFT SKELETTIC TISSUE INJURY MANAGING A COMPOSITION OF MESENQUIMATOSE MOTHER CELLS |
EP1620140B1 (en) | 2003-05-05 | 2013-10-09 | Ben-Gurion University Of The Negev Research And Development Authority | Injectable cross-linked polymeric preparations and uses thereof |
JP2005170816A (en) * | 2003-12-09 | 2005-06-30 | Naoki Ishiguro | Material for restoring cartilage, and method for producing the same |
WO2005065269A2 (en) * | 2003-12-29 | 2005-07-21 | Am Biosolutions | Compositions and method for decreasing the appearance of skin wrinkles |
US7678780B2 (en) * | 2003-12-29 | 2010-03-16 | Allan Mishra | Method of treating cancer using platelet releasate |
US20070122906A1 (en) * | 2003-12-29 | 2007-05-31 | Allan Mishra | Method of culturing cells |
EP1756272A2 (en) * | 2004-01-09 | 2007-02-28 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compounds, pharmaceutical compositions and therapeutic methods of preventing and treating diseases and disorders associated with amyloid fibril formation |
US7837708B2 (en) * | 2004-04-22 | 2010-11-23 | Arthrex, Inc. | Accelerated healing with intraoperative combination of suture and autogenous blood components |
US7462268B2 (en) * | 2004-08-20 | 2008-12-09 | Allan Mishra | Particle/cell separation device and compositions |
WO2006031738A1 (en) * | 2004-09-13 | 2006-03-23 | Hynes Richard A | Methods for treating open wounds |
US20080221660A1 (en) * | 2004-10-28 | 2008-09-11 | Medtronic Vascular, Inc. | Platelet Gel for Treatment of Aneurysms |
US20060095121A1 (en) * | 2004-10-28 | 2006-05-04 | Medtronic Vascular, Inc. | Autologous platelet gel on a stent graft |
US20100280493A1 (en) * | 2005-06-23 | 2010-11-04 | Asha Nayak | Methods and Systems for Treating Injured Cardiac Tissue |
US20070172472A1 (en) * | 2005-06-23 | 2007-07-26 | Asha Nayak | Methods and Systems for Treating Injured Cardiac Tissue |
WO2007002554A2 (en) * | 2005-06-23 | 2007-01-04 | Medtronic Vascular, Inc. | Methods and systems for treating injured cardiac tissue |
US20070093748A1 (en) * | 2005-06-23 | 2007-04-26 | Medtronic Vascular, Inc. | Methods and systems for treating injured cardiac tissue |
WO2007070660A2 (en) * | 2005-12-13 | 2007-06-21 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
JP4920964B2 (en) * | 2005-12-16 | 2012-04-18 | 光則 石本 | Dental materials and composite dental materials formed using hydroxyapatite |
CA2640185A1 (en) * | 2006-01-24 | 2007-08-02 | Christopher J. Centeno | Mesenchymal stem cell isolation and transplantation method and system to be used in a clinical setting |
US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
ITRM20060289A1 (en) * | 2006-05-31 | 2007-12-01 | Ranieri Cancedda | BIO MEMBRANE ENGINEERED OSTEO ANGIOGENICA AND ITS USES FOR THE REGENERATION OF BONE FABRIC |
EP4162936A1 (en) * | 2006-09-28 | 2023-04-12 | The Children's Medical Center Corporation | Methods and collagen products for tissue repair |
US8052969B2 (en) * | 2006-12-28 | 2011-11-08 | Arthrex, Inc. | Method of making plasma enriched with platelets using a double syringe system where the second sytringe is within the first syringe and use thereof |
US20080193424A1 (en) * | 2007-02-09 | 2008-08-14 | Biomet Biologics, Inc. | Treatment of tissue defects with a therapeutic composition |
ES2325938B1 (en) * | 2007-02-27 | 2010-07-23 | Rafael Marquez De Aracena Del Cid | USE OF PLATES TO MANUFACTURE A MEDICINAL PRODUCT FOR THE TREATMENT OF EYE PATHOLOGIES |
US8034014B2 (en) | 2007-03-06 | 2011-10-11 | Biomet Biologics, Llc | Angiogenesis initation and growth |
EP2146794B1 (en) | 2007-04-12 | 2016-10-19 | Biomet Biologics, LLC | Buoy suspension fractionation system |
US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
US20080269762A1 (en) * | 2007-04-25 | 2008-10-30 | Biomet Manufacturing Corp. | Method and device for repair of cartilage defects |
US7901344B2 (en) * | 2007-05-11 | 2011-03-08 | Biomet Biologics, Llc | Methods of reducing surgical complications in cancer patients |
US9095562B2 (en) * | 2007-07-05 | 2015-08-04 | Regenerative Sciences, Inc. | Methods and compositions for optimized expansion and implantation of mesenchymal stem cells |
US20090053208A1 (en) * | 2007-08-20 | 2009-02-26 | Medtronic Vascular, Inc. | Methods and Systems for Improving Tissue Perfusion |
CN101945994A (en) * | 2007-12-19 | 2011-01-12 | 再生科学有限责任公司 | Compositions and methods to promote implantation and engrafment of stem cells |
WO2009085769A2 (en) * | 2007-12-20 | 2009-07-09 | Zimmer Orthobiologics, Inc. | Compositions and methods for repair of connective tissue |
US9370558B2 (en) | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
AU2009215188B2 (en) | 2008-02-13 | 2014-09-18 | Dana-Farber Cancer Institute, Inc. | Continuous cell programming devices |
EP2567692B1 (en) | 2008-02-27 | 2016-04-06 | Biomet Biologics, LLC | Use of a device for obtaining interleukin-1 receptor antagonist rich solutions |
US8753690B2 (en) | 2008-02-27 | 2014-06-17 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
EP2254991B1 (en) | 2008-02-29 | 2018-08-22 | Biomet Manufacturing, LLC | A system and process for separating a material |
EP2257176B1 (en) | 2008-03-14 | 2013-09-18 | Regenerative Sciences, LLC | Compositions and methods for cartilage repair |
US8999001B2 (en) * | 2008-04-21 | 2015-04-07 | Ao Technology Ag | Biocompatible implant |
US20090297485A1 (en) * | 2008-05-28 | 2009-12-03 | Allan Mishra | Compositions and methods for treating psychiatric and neurodegenerative disorders |
US20100112081A1 (en) | 2008-10-07 | 2010-05-06 | Bioparadox, Llc | Use of platelet rich plasma composition in the treatment of cardiac conduction abnormalities |
JP2012505239A (en) * | 2008-10-09 | 2012-03-01 | バイオパラドックス,リミテッド ライアビリティー カンパニー | Platelet-rich plasma preparation for heart treatment |
GB0820492D0 (en) | 2008-11-07 | 2008-12-17 | Sportcell | Cell compositions and uses thereof |
US20110245804A1 (en) | 2008-12-05 | 2011-10-06 | Regenerative Sciences, Llc | Methods and Compositions to Facilitate Repair of Avascular Tissue |
US20100168022A1 (en) * | 2008-12-11 | 2010-07-01 | Centeno Christopher J | Use of In-Vitro Culture to Design or Test Personalized Treatment Regimens |
US8921037B2 (en) * | 2008-12-16 | 2014-12-30 | Bo Han | PF4-depleted platelet rich plasma preparations and methods for hard and soft tissue repair |
US9227089B1 (en) | 2009-01-14 | 2016-01-05 | Pgfx Patent Holdings, Llc | Skin treatment for promoting hair growth |
US20100196497A1 (en) * | 2009-02-02 | 2010-08-05 | Therapy Products, Inc. | Method of Treating Tissue Using Platelet-Rich Plasma in Combination with Low-Level Laser Therapy |
US9259442B2 (en) | 2009-02-05 | 2016-02-16 | Pierre Philippart | Method and means for producing tissues and tissues obtained |
US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
US20100233282A1 (en) * | 2009-03-13 | 2010-09-16 | Allan Mishra | Device and methods for delivery of bioactive materials to the right side of the heart |
US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
EP2461828B1 (en) | 2009-07-31 | 2017-06-21 | President and Fellows of Harvard College | Programming of cells for tolerogenic therapies |
US9763875B2 (en) | 2009-08-27 | 2017-09-19 | Biomet Biologics, Llc | Implantable device for production of interleukin-1 receptor antagonist |
US20110054929A1 (en) * | 2009-09-01 | 2011-03-03 | Cell Solutions Colorado Llc | Stem Cell Marketplace |
US9113950B2 (en) | 2009-11-04 | 2015-08-25 | Regenerative Sciences, Llc | Therapeutic delivery device |
US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
EP2611456A2 (en) | 2010-09-03 | 2013-07-10 | Biomet Biologics, LLC | Methods and compositions for delivering interleukin-1 receptor antagonist |
EP2619356A4 (en) * | 2010-09-22 | 2014-04-09 | Univ Virginia Commonwealth | Preparation rich in growth factor-based fibrous matrices for tissue engineering, growth factor delivery, and wound healing |
US9555171B2 (en) | 2010-09-30 | 2017-01-31 | Depuy Mitek, Llc | Methods and devices for collecting separate components of whole blood |
DK2624873T3 (en) | 2010-10-06 | 2020-03-02 | Harvard College | INJECTABLE, PORE-MAKING HYDROGLES FOR MATERIAL-BASED CELL THERAPIES |
ES2878089T3 (en) | 2011-04-28 | 2021-11-18 | Harvard College | Injectable preformed macroscopic three-dimensional scaffolds for minimally invasive administration |
US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
CA2838125A1 (en) | 2011-06-03 | 2012-12-06 | President And Fellows Of Harvard College | In situ antigen-generating cancer vaccine |
CN103930542A (en) | 2011-06-29 | 2014-07-16 | 生物修复疗法有限公司 | Brown fat cell compositions and methods |
EP2628484B9 (en) | 2012-02-17 | 2016-08-17 | Opko Lab Europe Sl. | Platelet-rich plasma compositions |
SI2838515T1 (en) | 2012-04-16 | 2020-07-31 | President And Fellows Of Harvard College | Mesoporous silica compositions for modulating immune responses |
ES2442242B1 (en) * | 2012-08-09 | 2014-11-25 | Biotechnology Institute, I Mas D, S.L. | Composition with growth factors intended for intranasal treatment of a neurodegenerative disease or other pathology of the central nervous system, and its manufacturing method. |
US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
EP3798226A1 (en) | 2013-02-01 | 2021-03-31 | Children's Medical Center Corporation | Collagen scaffolds |
US9878011B2 (en) | 2013-03-15 | 2018-01-30 | Biomet Biologics, Llc | Treatment of inflammatory respiratory disease using biological solutions |
US9758806B2 (en) | 2013-03-15 | 2017-09-12 | Biomet Biologics, Llc | Acellular compositions for treating inflammatory disorders |
US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
CN105263511A (en) | 2013-03-21 | 2016-01-20 | 科尔普兰特有限公司 | Compositions comprising collagen and PRP for tissue regeneration |
US20160051701A1 (en) * | 2013-03-28 | 2016-02-25 | Cell-Innovations Ip Pty Ltd | Improved methods for osteoarthritis therapy |
US20140356893A1 (en) | 2013-06-04 | 2014-12-04 | Allan Mishra | Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation |
US9833474B2 (en) | 2013-11-26 | 2017-12-05 | Biomet Biologies, LLC | Methods of mediating macrophage phenotypes |
US10682400B2 (en) | 2014-04-30 | 2020-06-16 | President And Fellows Of Harvard College | Combination vaccine devices and methods of killing cancer cells |
EP3209768A1 (en) | 2014-07-25 | 2017-08-30 | Recellerate Inc. | Methods of treating exercise-induced pulmonary hemorrhage |
US10441635B2 (en) | 2014-11-10 | 2019-10-15 | Biomet Biologics, Llc | Methods of treating pain using protein solutions |
WO2016123573A1 (en) | 2015-01-30 | 2016-08-04 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
US9763800B2 (en) | 2015-03-18 | 2017-09-19 | Biomet C. V. | Implant configured for hammertoe and small bone fixation |
WO2016164705A1 (en) | 2015-04-10 | 2016-10-13 | Omar Abdel-Rahman Ali | Immune cell trapping devices and methods for making and using the same |
WO2017136837A1 (en) | 2016-02-06 | 2017-08-10 | President And Fellows Of Harvard College | Recapitulating the hematopoietic niche to reconstitute immunity |
US9861410B2 (en) | 2016-05-06 | 2018-01-09 | Medos International Sarl | Methods, devices, and systems for blood flow |
AU2017295704B2 (en) | 2016-07-13 | 2023-07-13 | President And Fellows Of Harvard College | Antigen-presenting cell-mimetic scaffolds and methods for making and using the same |
EP3870190A4 (en) | 2018-10-26 | 2022-09-07 | Alkahest, Inc. | Use of plasma and plasma fractions for improvement of pain, wound healing, and postoperative recovery |
JP2022553837A (en) | 2019-11-04 | 2022-12-26 | アルカヘスト,インコーポレイテッド | Plasma fraction for use in muscle regeneration |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4663289A (en) * | 1984-06-22 | 1987-05-05 | Veech Richard L | Electrolyte solutions and in vitro use thereof |
US5124316A (en) * | 1986-11-14 | 1992-06-23 | President And Fellows Of Harvard College | Method for periodontal regeneration |
US5510102A (en) * | 1995-01-23 | 1996-04-23 | The Regents Of The University Of California | Plasma and polymer containing surgical hemostatic adhesives |
US6454804B1 (en) * | 1999-10-08 | 2002-09-24 | Bret A. Ferree | Engineered tissue annulus fibrosis augmentation methods and apparatus |
Family Cites Families (141)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US236573A (en) * | 1881-01-11 | Velocipede | ||
US6437A (en) * | 1849-05-08 | Improvement | ||
US82220A (en) * | 1868-09-15 | Improvement in beake foe yakn-beam of looms | ||
US31978A (en) * | 1861-04-09 | Transmitting motion | ||
US1769547A (en) * | 1929-01-07 | 1930-07-01 | Robbins Maurice | Necktie |
US4081331A (en) | 1976-04-05 | 1978-03-28 | Gunther Weiss | Portable water distillation apparatus |
US4414108A (en) * | 1980-05-09 | 1983-11-08 | The United States Of America As Represented By The Department Of Health And Human Services | Apparatus and method for continuous countercurrent extraction and particle separation |
CA1244774A (en) * | 1983-11-09 | 1988-11-15 | Thomas Jefferson University | Medium for storing blood platelets |
US4957742A (en) | 1984-11-29 | 1990-09-18 | Regents Of The University Of Minnesota | Method for promoting hair growth |
US5165938A (en) | 1984-11-29 | 1992-11-24 | Regents Of The University Of Minnesota | Wound healing agents derived from platelets |
US5178883A (en) | 1984-11-29 | 1993-01-12 | Regents Of The University Of Minnesota | Method for promoting hair growth |
NZ214396A (en) * | 1984-12-11 | 1988-02-29 | Ici Australia Ltd | Preparation of gas bubble-sensitised explosive compositions |
US4931395A (en) * | 1986-12-08 | 1990-06-05 | Dana-Farber Cancer Institute | Monoclonal antibody specific to neutrophils |
US5079236A (en) | 1987-05-27 | 1992-01-07 | Hyal Pharmaceutical Corporation | Pure, sterile, pyrogen-free hyaluronic acid formulations their methods of preparation and methods of use |
US4902287A (en) * | 1987-09-24 | 1990-02-20 | Miles Inc. | Sterilizable system for blood storage |
US5209724A (en) * | 1988-04-11 | 1993-05-11 | Dhaliwal Avtar S | Composite anesthetic article and method of use |
US5079230A (en) * | 1988-09-12 | 1992-01-07 | Pitman-Moore, Inc. | Stable bioactive somatotropins |
US4969888A (en) * | 1989-02-09 | 1990-11-13 | Arie Scholten | Surgical protocol for fixation of osteoporotic bone using inflatable device |
US5428008A (en) | 1989-04-14 | 1995-06-27 | Prp, Inc. | Therapeutic composition of micellar structures capable of promoting hemotasis |
IL95641A0 (en) * | 1989-09-15 | 1991-06-30 | Curative Tech Inc | Preparation of a platelet releasate product |
US5599558A (en) | 1989-09-15 | 1997-02-04 | Curative Technologies, Inc. | Selecting amounts of platelet releasate for efficacious treatment of tissue |
US5147776A (en) | 1990-02-26 | 1992-09-15 | University Of Iowa Research Foundation | Use of 2,5-anhydromannitol for control of pH during blood storage |
WO1992001716A1 (en) * | 1990-07-23 | 1992-02-06 | Zymogenetics, Inc. | Protease resistant pdgf and methods of use |
US5336387A (en) | 1990-09-11 | 1994-08-09 | Bioseparations, Inc. | Electrical separator apparatus and method of counterflow gradient focusing |
US5641622A (en) | 1990-09-13 | 1997-06-24 | Baxter International Inc. | Continuous centrifugation process for the separation of biological components from heterogeneous cell populations |
US5385937A (en) | 1991-04-10 | 1995-01-31 | Brigham & Women's Hospital | Nitrosation of homocysteine as a method for treating homocysteinemia |
US5474891A (en) | 1991-10-30 | 1995-12-12 | Thomas Jefferson University | Plasma-based platelet concentrate preparations with additive |
US5599556A (en) * | 1991-12-31 | 1997-02-04 | Abbott Laboratories | Prolamine coatings for taste masking |
US5313953A (en) * | 1992-01-14 | 1994-05-24 | Incontrol, Inc. | Implantable cardiac patient monitor |
US5785869A (en) * | 1992-02-10 | 1998-07-28 | Baxter International Inc. | Method for creating a leukocyte rich sample from a mixed population of blood cells |
AU3738393A (en) * | 1992-04-02 | 1993-11-08 | Smithkline Beecham Corporation | Compounds useful for treating inflammatory diseases and for inhibiting production of tumor necrosis factor |
US5269290B1 (en) | 1992-04-17 | 1996-06-11 | Instratek Inc | Plantar fasciotomy surgical procedure |
US5403272A (en) * | 1992-05-29 | 1995-04-04 | Baxter International Inc. | Apparatus and methods for generating leukocyte free platelet concentrate |
EP1338648B1 (en) * | 1992-05-29 | 2005-11-30 | The University Of North Carolina At Chapel Hill | Pharmaceutically acceptable fixed-dried human blood platelets |
US5494590A (en) * | 1992-06-11 | 1996-02-27 | Becton Dickinson | Method of using anticoagulant solution in blood separation |
US5449688A (en) | 1993-03-30 | 1995-09-12 | The United States Of America As Represented By The Department Of Health And Human Services | Method of treating chronic inflammatory diseases |
EP1118326A3 (en) | 1993-05-21 | 2002-07-31 | The Liposome Company, Inc. | Reduction of liposome-induced adverse physiological reactions |
EP0720658A1 (en) * | 1993-09-23 | 1996-07-10 | E.I. Du Pont De Nemours And Company | An electrophoretic method for the isolation and separation of microorganisms |
US5662813A (en) * | 1994-10-21 | 1997-09-02 | Bioseparations, Inc. | Method for separation of nucleated fetal erythrocytes from maternal blood samples |
US7169547B2 (en) | 1994-12-05 | 2007-01-30 | New York Blood Center, Inc. | High concentration white blood cells as a therapeutic product |
US5789147A (en) | 1994-12-05 | 1998-08-04 | New York Blood Center, Inc. | Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulated blood |
US5585007A (en) * | 1994-12-07 | 1996-12-17 | Plasmaseal Corporation | Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant |
US5614204A (en) | 1995-01-23 | 1997-03-25 | The Regents Of The University Of California | Angiographic vascular occlusion agents and a method for hemostatic occlusion |
US5643786A (en) * | 1995-01-27 | 1997-07-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for isolating dendritic cells |
US5733545A (en) * | 1995-03-03 | 1998-03-31 | Quantic Biomedical Partners | Platelet glue wound sealant |
AUPN166195A0 (en) | 1995-03-13 | 1995-04-06 | Norvet Research Pty Limited | Process for glucan extraction |
US5788682A (en) * | 1995-04-28 | 1998-08-04 | Maget; Henri J.R. | Apparatus and method for controlling oxygen concentration in the vicinity of a wound |
US5814022A (en) | 1996-02-06 | 1998-09-29 | Plasmaseal Llc | Method and apparatus for applying tissue sealant |
US5834418A (en) * | 1996-03-20 | 1998-11-10 | Theratechnologies, Inc. | Process for the preparation of platelet growth factors extract |
JP2000509307A (en) * | 1996-04-30 | 2000-07-25 | メドトロニック,インコーポレイテッド | Method for producing autologous fibrin sealant |
WO2000062828A1 (en) * | 1996-04-30 | 2000-10-26 | Medtronic, Inc. | Autologous fibrin sealant and method for making the same |
US6280473B1 (en) * | 1996-08-19 | 2001-08-28 | Macropore, Inc. | Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration |
US5935850A (en) * | 1996-09-30 | 1999-08-10 | The Research Foundation Of State University Of New York | Model for cell migration and use thereof |
US6120520A (en) | 1997-05-27 | 2000-09-19 | Angiotrax, Inc. | Apparatus and methods for stimulating revascularization and/or tissue growth |
US6102926A (en) | 1996-12-02 | 2000-08-15 | Angiotrax, Inc. | Apparatus for percutaneously performing myocardial revascularization having means for sensing tissue parameters and methods of use |
EP0988552B1 (en) | 1997-06-10 | 2010-11-24 | Lpath, Inc. | Methods for early detection of heart disease |
DE19747149C2 (en) | 1997-10-24 | 2000-02-10 | Harald G W Kuebler | Surgical cutting instrument |
US6098631A (en) | 1998-01-21 | 2000-08-08 | The Regents Of The University Of Michigan | Compositions and methods for treating autoimmune disease |
US6712851B1 (en) * | 1998-01-23 | 2004-03-30 | Macropore Biosurgery, Inc. | Resorbable, macro-porous non-collapsing and flexible membrane barrier for skeletal repair and regeneration |
US6183442B1 (en) | 1998-03-02 | 2001-02-06 | Board Of Regents Of The University Of Texas System | Tissue penetrating device and methods for using same |
US7771719B1 (en) * | 2000-01-11 | 2010-08-10 | Genentech, Inc. | Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E |
AU762262B2 (en) | 1998-07-02 | 2003-06-19 | Stichting Skeletal Tissue Engineering Group Amsterdam | Bone cement with antimicrobial peptides |
FR2781485B1 (en) * | 1998-07-21 | 2003-08-08 | Denis Barritault | BIOCOMPATIBLE POLYMERS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM |
AU759991B2 (en) | 1998-08-26 | 2003-05-01 | Neo Mend, Inc. | Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers or covering structures |
CA2320097C (en) * | 1998-12-09 | 2009-04-14 | Cook Incorporated | Hollow, curved, superelastic medical needle |
US6306171B1 (en) * | 1998-12-09 | 2001-10-23 | Iowa State University Research Foundation, Inc. | Total elbow arthroplasty system |
JP2000214965A (en) * | 1999-01-25 | 2000-08-04 | Toshiba Corp | Computer system and method for managing battery event |
US6322785B1 (en) | 1999-03-02 | 2001-11-27 | Natrex Technologies | Methods and compositions for bone graft implants |
US6432119B1 (en) * | 1999-03-17 | 2002-08-13 | Angiotrax, Inc. | Apparatus and methods for performing percutaneous myocardial revascularization and stimulating angiogenesis using autologous materials |
US6315992B1 (en) | 1999-06-30 | 2001-11-13 | Tissuegene Co. | Generating cartilage in a mammal using fibroblasts transfected with a vector encoding TGF-β-1 |
DE19960504A1 (en) | 1999-12-15 | 2001-08-16 | Curasan Ag | Regenerating agent |
US6447443B1 (en) | 2001-01-13 | 2002-09-10 | Medtronic, Inc. | Method for organ positioning and stabilization |
US6592566B2 (en) | 2000-02-03 | 2003-07-15 | Arizona Board Of Regents | Method for forming an endovascular occlusion |
US20020006437A1 (en) | 2000-05-01 | 2002-01-17 | Grooms Jamie M. | Non-migration tissue capsule |
AU2001259449A1 (en) * | 2000-05-03 | 2001-11-12 | Eligix, Inc. | Whole blood separator apparatus and method of use |
US6922685B2 (en) * | 2000-05-22 | 2005-07-26 | Mci, Inc. | Method and system for managing partitioned data resources |
JP5089006B2 (en) * | 2000-06-29 | 2012-12-05 | ピラマル ヘルスケア (カナダ) リミテッド | Compositions and methods for repair and regeneration of cartilage and other tissues |
US20020032155A1 (en) * | 2000-06-30 | 2002-03-14 | Ferree Bret A. | Method of treating disc herniation and disc degeneration with concentrated growth and differentiation factors |
US20030185812A1 (en) * | 2000-06-30 | 2003-10-02 | Ferree Bret A. | Method of treating dural leaks with platelet-rich plasma (PRP) |
AUPQ941000A0 (en) | 2000-08-14 | 2000-09-07 | Cooper, Michael | An endoscopic surgical device |
MXPA03001529A (en) * | 2000-08-22 | 2004-04-02 | Ribapharm Inc | Methods of drug delivery to hepatocytes and treatment of flaviviridae infections. |
JP5106738B2 (en) | 2000-09-06 | 2012-12-26 | ジョンズ・ホプキンス・ユニバーシティ | Cardiac arrhythmia therapy |
US6554801B1 (en) | 2000-10-26 | 2003-04-29 | Advanced Cardiovascular Systems, Inc. | Directional needle injection drug delivery device and method of use |
US7628780B2 (en) | 2001-01-13 | 2009-12-08 | Medtronic, Inc. | Devices and methods for interstitial injection of biologic agents into tissue |
US7740623B2 (en) * | 2001-01-13 | 2010-06-22 | Medtronic, Inc. | Devices and methods for interstitial injection of biologic agents into tissue |
US6837848B2 (en) | 2003-01-15 | 2005-01-04 | Medtronic, Inc. | Methods and apparatus for accessing and stabilizing an area of the heart |
US6942880B1 (en) * | 2001-04-09 | 2005-09-13 | Medtronic, Inc. | Autologous platelet gel having beneficial geometric shapes and methods of making the same |
US20030152639A1 (en) * | 2001-07-03 | 2003-08-14 | Calvin Britton | Novel wound healing composition not containing bovine-derived activating reagents |
US20030007957A1 (en) * | 2001-07-03 | 2003-01-09 | Calvin Britton | Novel wound healing composition not containing bovine-derived activating reagents |
EP1416943B1 (en) * | 2001-08-09 | 2012-05-02 | Giuseppe Intini | Tissue implants and methods for making and using same |
US7357947B2 (en) * | 2001-09-10 | 2008-04-15 | Biomet, Inc. | Bone graft material incorporating demineralized bone matrix and lipids |
WO2003050536A2 (en) * | 2001-12-05 | 2003-06-19 | Gambro, Inc. | Methods and apparatus for separation of blood components |
US7211191B2 (en) | 2004-09-30 | 2007-05-01 | Thermogenesis Corp. | Blood component separation method and apparatus |
US7241281B2 (en) * | 2002-04-08 | 2007-07-10 | Thermogenesis Corporation | Blood component separation method and apparatus |
US20030192554A1 (en) * | 2002-04-11 | 2003-10-16 | Ferree Bret A. | Methods and apparatus for adhering musculoskeletal tissues |
US7608258B2 (en) * | 2002-04-13 | 2009-10-27 | Allan Mishra | Method for treatment of tendinosis using platelet rich plasma |
US6811777B2 (en) | 2002-04-13 | 2004-11-02 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
EP1501582A4 (en) | 2002-04-24 | 2009-03-25 | Interpore Orthopaedics Inc | Blood separation and concentration system |
US6905612B2 (en) * | 2003-03-21 | 2005-06-14 | Hanuman Llc | Plasma concentrate apparatus and method |
US20030205538A1 (en) * | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
US20040182795A1 (en) * | 2003-03-21 | 2004-09-23 | Randel Dorian | Apparatus and method for concentration of plasma from whole blood |
US7166133B2 (en) * | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
US6982038B2 (en) * | 2002-06-14 | 2006-01-03 | Medtronic, Inc. | Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma |
US20070225614A1 (en) * | 2004-05-26 | 2007-09-27 | Endothelix, Inc. | Method and apparatus for determining vascular health conditions |
AR047712A1 (en) | 2002-09-07 | 2006-02-15 | Royal Veterinary College | TREATMENT METHOD OF A NATURAL SOFT SKELETTIC TISSUE INJURY MANAGING A COMPOSITION OF MESENQUIMATOSE MOTHER CELLS |
US6960214B2 (en) * | 2002-10-15 | 2005-11-01 | Zimmer Austin, Inc. | Method for performing automated microfracture |
US20040126885A1 (en) * | 2002-11-05 | 2004-07-01 | Cines Douglas B. | Delivery vehicle for recombinant proteins |
US20050015048A1 (en) * | 2003-03-12 | 2005-01-20 | Chiu Jessica G. | Infusion treatment agents, catheters, filter devices, and occlusion devices, and use thereof |
US7291450B2 (en) * | 2003-03-28 | 2007-11-06 | Smith & Nephew, Inc. | Preparation of a cell concentrate from a physiological solution |
US20050064042A1 (en) * | 2003-04-29 | 2005-03-24 | Musculoskeletal Transplant Foundation | Cartilage implant plug with fibrin glue and method for implantation |
US20040244806A1 (en) * | 2003-06-09 | 2004-12-09 | Ferree Bret A. | Treating disc herniation and other conditions with leukocytes |
US7338494B2 (en) * | 2003-08-19 | 2008-03-04 | Synthes (U.S.A.) | Spring-loaded awl |
SE0302983D0 (en) | 2003-11-11 | 2003-11-11 | Bone Support Ab | Apparatus for providing spongy bone with bone replacement and / or bone strengthening material and associated method |
WO2005065269A2 (en) * | 2003-12-29 | 2005-07-21 | Am Biosolutions | Compositions and method for decreasing the appearance of skin wrinkles |
US20070122906A1 (en) * | 2003-12-29 | 2007-05-31 | Allan Mishra | Method of culturing cells |
US7678780B2 (en) | 2003-12-29 | 2010-03-16 | Allan Mishra | Method of treating cancer using platelet releasate |
US20060064101A1 (en) * | 2004-02-12 | 2006-03-23 | Arthrocare Corporation | Bone access system |
EP1761562B1 (en) * | 2004-02-19 | 2013-09-11 | Dyax Corp. | Conformation specific antibodies |
US7462268B2 (en) * | 2004-08-20 | 2008-12-09 | Allan Mishra | Particle/cell separation device and compositions |
US20060095121A1 (en) | 2004-10-28 | 2006-05-04 | Medtronic Vascular, Inc. | Autologous platelet gel on a stent graft |
US7708152B2 (en) | 2005-02-07 | 2010-05-04 | Hanuman Llc | Method and apparatus for preparing platelet rich plasma and concentrates thereof |
US8092475B2 (en) * | 2005-04-15 | 2012-01-10 | Integra Lifesciences (Ireland) Ltd. | Ultrasonic horn for removal of hard tissue |
US20070172472A1 (en) * | 2005-06-23 | 2007-07-26 | Asha Nayak | Methods and Systems for Treating Injured Cardiac Tissue |
WO2007002554A2 (en) * | 2005-06-23 | 2007-01-04 | Medtronic Vascular, Inc. | Methods and systems for treating injured cardiac tissue |
US20070087061A1 (en) | 2005-10-14 | 2007-04-19 | Medafor, Incorporated | Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components |
EP2007404A2 (en) | 2006-03-23 | 2008-12-31 | Medtronic Vascular, Inc. | Methods and systems for treating injured cardiac tissue |
US20080045964A1 (en) | 2006-08-16 | 2008-02-21 | Allan Mishra | Device for cartilage repair |
EP4162936A1 (en) | 2006-09-28 | 2023-04-12 | The Children's Medical Center Corporation | Methods and collagen products for tissue repair |
US20080089867A1 (en) | 2006-10-13 | 2008-04-17 | Brian Fernandes | Method of increasing retention, survival and proliferation of transplanted cells in vivo |
US20090053208A1 (en) | 2007-08-20 | 2009-02-26 | Medtronic Vascular, Inc. | Methods and Systems for Improving Tissue Perfusion |
US8016814B2 (en) | 2008-03-10 | 2011-09-13 | Medtronic Vascular, Inc. | Guidewires and delivery catheters having fiber optic sensing components and related systems and methods |
WO2010005557A2 (en) | 2008-07-07 | 2010-01-14 | Arteriocyte Medical Systems, Inc. | Biological therapeutic compositions and methods thereof |
US20100112081A1 (en) * | 2008-10-07 | 2010-05-06 | Bioparadox, Llc | Use of platelet rich plasma composition in the treatment of cardiac conduction abnormalities |
JP2012505239A (en) | 2008-10-09 | 2012-03-01 | バイオパラドックス,リミテッド ライアビリティー カンパニー | Platelet-rich plasma preparation for heart treatment |
US8177072B2 (en) | 2008-12-04 | 2012-05-15 | Thermogenesis Corp. | Apparatus and method for separating and isolating components of a biological fluid |
US8921037B2 (en) | 2008-12-16 | 2014-12-30 | Bo Han | PF4-depleted platelet rich plasma preparations and methods for hard and soft tissue repair |
US20100196497A1 (en) | 2009-02-02 | 2010-08-05 | Therapy Products, Inc. | Method of Treating Tissue Using Platelet-Rich Plasma in Combination with Low-Level Laser Therapy |
US20100233282A1 (en) | 2009-03-13 | 2010-09-16 | Allan Mishra | Device and methods for delivery of bioactive materials to the right side of the heart |
WO2011127071A1 (en) | 2010-04-05 | 2011-10-13 | Allan Mishra | Platelet rich plasma formulations |
EP2619356A4 (en) * | 2010-09-22 | 2014-04-09 | Univ Virginia Commonwealth | Preparation rich in growth factor-based fibrous matrices for tissue engineering, growth factor delivery, and wound healing |
US20130197468A1 (en) * | 2012-01-26 | 2013-08-01 | Carnegie Mellon University | Device for Intramyocardial Delivery |
-
2003
- 2003-04-11 US US10/412,821 patent/US6811777B2/en not_active Expired - Lifetime
- 2003-04-14 EP EP03718407.4A patent/EP1494535B1/en not_active Expired - Lifetime
- 2003-04-14 AU AU2003221946A patent/AU2003221946B2/en not_active Expired
- 2003-04-14 KR KR1020047016367A patent/KR101019188B1/en active IP Right Grant
- 2003-04-14 WO PCT/US2003/011623 patent/WO2003088905A2/en active Application Filing
- 2003-04-14 EP EP10009448.1A patent/EP2258379B1/en not_active Expired - Lifetime
- 2003-04-14 JP JP2003585658A patent/JP4493346B2/en not_active Expired - Lifetime
- 2003-04-14 ES ES03718407.4T patent/ES2613378T3/en not_active Expired - Lifetime
-
2004
- 2004-09-15 US US10/941,124 patent/US7314617B2/en not_active Expired - Lifetime
-
2006
- 2006-07-27 US US11/494,166 patent/US8163277B2/en active Active
-
2007
- 2007-07-13 US US11/777,968 patent/US9320762B2/en active Active
-
2008
- 2008-06-17 US US12/140,626 patent/US20080248084A1/en not_active Abandoned
- 2008-06-17 US US12/140,540 patent/US20080248082A1/en not_active Abandoned
- 2008-06-17 US US12/140,499 patent/US20080248081A1/en not_active Abandoned
- 2008-06-17 US US12/140,586 patent/US8088371B2/en active Active
-
2010
- 2010-01-21 JP JP2010011183A patent/JP4615064B2/en not_active Expired - Lifetime
-
2012
- 2012-03-13 US US13/418,948 patent/US8617539B2/en not_active Expired - Lifetime
-
2016
- 2016-03-29 US US15/084,342 patent/US20160206657A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4663289A (en) * | 1984-06-22 | 1987-05-05 | Veech Richard L | Electrolyte solutions and in vitro use thereof |
US5124316A (en) * | 1986-11-14 | 1992-06-23 | President And Fellows Of Harvard College | Method for periodontal regeneration |
US5510102A (en) * | 1995-01-23 | 1996-04-23 | The Regents Of The University Of California | Plasma and polymer containing surgical hemostatic adhesives |
US6454804B1 (en) * | 1999-10-08 | 2002-09-24 | Bret A. Ferree | Engineered tissue annulus fibrosis augmentation methods and apparatus |
Non-Patent Citations (1)
Title |
---|
See also references of EP1494535A2 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9114334B2 (en) | 2002-05-24 | 2015-08-25 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US8992862B2 (en) | 2009-04-03 | 2015-03-31 | Biomet Biologics, Llc | All-in-one means of separating blood components |
Also Published As
Publication number | Publication date |
---|---|
US20080248084A1 (en) | 2008-10-09 |
KR101019188B1 (en) | 2011-03-03 |
EP1494535A2 (en) | 2005-01-12 |
US8088371B2 (en) | 2012-01-03 |
ES2613378T3 (en) | 2017-05-24 |
JP2005528401A (en) | 2005-09-22 |
US20050100536A1 (en) | 2005-05-12 |
US20060263407A1 (en) | 2006-11-23 |
JP4615064B2 (en) | 2011-01-19 |
US6811777B2 (en) | 2004-11-02 |
US20080248082A1 (en) | 2008-10-09 |
EP1494535A4 (en) | 2005-10-26 |
EP2258379B1 (en) | 2014-12-17 |
JP4493346B2 (en) | 2010-06-30 |
AU2003221946B2 (en) | 2007-10-04 |
WO2003088905A2 (en) | 2003-10-30 |
KR20050029118A (en) | 2005-03-24 |
US8617539B2 (en) | 2013-12-31 |
EP1494535B1 (en) | 2017-01-18 |
US20070264245A1 (en) | 2007-11-15 |
US8163277B2 (en) | 2012-04-24 |
EP2258379A1 (en) | 2010-12-08 |
US20160206657A1 (en) | 2016-07-21 |
US20080248081A1 (en) | 2008-10-09 |
US20120183520A1 (en) | 2012-07-19 |
JP2010100648A (en) | 2010-05-06 |
US9320762B2 (en) | 2016-04-26 |
AU2003221946A1 (en) | 2003-11-03 |
US20030194397A1 (en) | 2003-10-16 |
US20080254093A1 (en) | 2008-10-16 |
US7314617B2 (en) | 2008-01-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2003088905A3 (en) | Compositions and minimally invasive methods for treating incomplete tissue repair | |
WO2004031350A3 (en) | Modulation of forkhead box o1a expression | |
AU2003262872A1 (en) | Thermotherapy method for treatment and prevention of cancer in male and female patients and cosmetic ablation of tissue | |
WO2006071997A3 (en) | Treatment for cutaneous metastases | |
EP1461352A4 (en) | Antisense modulation of connective tissue growth factor expression | |
AU2001253038A1 (en) | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives | |
WO2004043218A3 (en) | Surgical tools and techniques for stimulation | |
BR0309890A (en) | Pharmaceutical composition containing blood plasma or blood serum used in the treatment of lesions, as well as its method and application process | |
WO2002003872A3 (en) | Application of photochemotherapy for the treatment of cardiac arrhythmias | |
WO2003028802A3 (en) | Devices for treating atrial fibrilation | |
AU2003253877A1 (en) | Thermotherapy method for treatment and prevention of breast cancer and cancer in other organs | |
AU2003215263A1 (en) | Electrosurgical apparatus and methods for treating joint tissue | |
EP1571969A3 (en) | Systems and methods for electrosurgical tissue treatment | |
WO2004091540A3 (en) | Methods of treating pain and compositions for use therefor | |
WO2005000213A8 (en) | Method for treating diseases using hsp90-inhibiting agents in combination with enzyme inhibitors | |
WO2005018549A3 (en) | Methods and compositions for tissue repair | |
WO2005037323A3 (en) | Use of gro to treat or prevent inflammation | |
AU2003224742A1 (en) | Method of administering buprenorphine to treat depression | |
SI1581235T1 (en) | Use of spongosine (2-methoxyadenosein) for the treatment of pain, in particular hyperalgesia | |
WO2002074323A3 (en) | Using neural thread proteins to treat tumors and other hyperproliferative disorders | |
CA2534577A1 (en) | Method for promoting bone growth | |
WO2004052404A3 (en) | Glycogen synthase kinase-3 inhibitors | |
WO2004093813A3 (en) | Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders | |
WO2001066101A3 (en) | Treatment of psoriasis | |
WO2003022203A3 (en) | Products and methods for treating microbial infections |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2003221946 Country of ref document: AU |
|
REEP | Request for entry into the european phase |
Ref document number: 2003718407 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003718407 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003585658 Country of ref document: JP Ref document number: 1020047016367 Country of ref document: KR |
|
WWP | Wipo information: published in national office |
Ref document number: 2003718407 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1020047016367 Country of ref document: KR |