WO2003094839A8 - Pyrimidinone compounds, compositions and methods - Google Patents

Pyrimidinone compounds, compositions and methods

Info

Publication number
WO2003094839A8
WO2003094839A8 PCT/US2003/013627 US0313627W WO03094839A8 WO 2003094839 A8 WO2003094839 A8 WO 2003094839A8 US 0313627 W US0313627 W US 0313627W WO 03094839 A8 WO03094839 A8 WO 03094839A8
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
pyrimidinone compounds
compounds
pyrimidinone
Prior art date
Application number
PCT/US2003/013627
Other languages
French (fr)
Other versions
WO2003094839A3 (en
WO2003094839A2 (en
Inventor
Han-Jie Zhou
David J C Morgans Jr
Steven David Knight
Kenneth A Newlander
Dashyant Dhanak
Nicholas D Adams
Gustave Bergnes
Original Assignee
Cytokinetics Inc
Smithkline Beecham Corp
Han-Jie Zhou
David J C Morgans Jr
Steven David Knight
Kenneth A Newlander
Dashyant Dhanak
Nicholas D Adams
Gustave Bergnes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002485148A priority Critical patent/CA2485148A1/en
Priority to NZ537076A priority patent/NZ537076A/en
Priority to AU2003223786A priority patent/AU2003223786A1/en
Priority to EP03719989A priority patent/EP1503993A4/en
Priority to BRPI0309892-3A priority patent/BR0309892A2/en
Priority to MXPA04011074A priority patent/MXPA04011074A/en
Priority to JP2004502928A priority patent/JP2006508030A/en
Application filed by Cytokinetics Inc, Smithkline Beecham Corp, Han-Jie Zhou, David J C Morgans Jr, Steven David Knight, Kenneth A Newlander, Dashyant Dhanak, Nicholas D Adams, Gustave Bergnes filed Critical Cytokinetics Inc
Publication of WO2003094839A2 publication Critical patent/WO2003094839A2/en
Publication of WO2003094839A8 publication Critical patent/WO2003094839A8/en
Publication of WO2003094839A3 publication Critical patent/WO2003094839A3/en
Priority to IS7520A priority patent/IS7520A/en
Priority to IL16504604A priority patent/IL165046A0/en
Priority to NO20045043A priority patent/NO20045043L/en
Priority to IL187528A priority patent/IL187528A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
PCT/US2003/013627 2002-05-09 2003-05-02 Pyrimidinone compounds, compositions and methods WO2003094839A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
MXPA04011074A MXPA04011074A (en) 2002-05-09 2003-05-02 Pyrimidinone compounds, compositions and methods.
NZ537076A NZ537076A (en) 2002-05-09 2003-05-02 Pyrimidinone compounds, compositions and methods
AU2003223786A AU2003223786A1 (en) 2002-05-09 2003-05-02 Compounds, methods and compositions
EP03719989A EP1503993A4 (en) 2002-05-09 2003-05-02 Compounds, methods and compositions
BRPI0309892-3A BR0309892A2 (en) 2002-05-09 2003-05-02 compound, composition, methods for modulating ksp kinesin activity, inhibiting ksp, and for treating a cell proliferative disease, and use of a compound
CA002485148A CA2485148A1 (en) 2002-05-09 2003-05-02 Pyrimidinone compounds, compositions and methods
JP2004502928A JP2006508030A (en) 2002-05-09 2003-05-02 Pyrimidinone compounds, compositions and methods
IS7520A IS7520A (en) 2002-05-09 2004-11-03 Pyrimidinone Compounds, Compositions and Methods
IL16504604A IL165046A0 (en) 2002-05-09 2004-11-04 Pyrimidinone compounds, compositions and methods
NO20045043A NO20045043L (en) 2002-05-09 2004-11-19 Pyrimidinone Compounds, Compositions and Methods
IL187528A IL187528A0 (en) 2002-05-09 2007-11-20 Use of pyrimidine compounds in the manufacture of medicaments

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37965802P 2002-05-09 2002-05-09
US60/379,658 2002-05-09

Publications (3)

Publication Number Publication Date
WO2003094839A2 WO2003094839A2 (en) 2003-11-20
WO2003094839A8 true WO2003094839A8 (en) 2004-06-24
WO2003094839A3 WO2003094839A3 (en) 2004-09-16

Family

ID=29420548

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/013627 WO2003094839A2 (en) 2002-05-09 2003-05-02 Pyrimidinone compounds, compositions and methods

Country Status (20)

Country Link
US (2) US7166595B2 (en)
EP (1) EP1503993A4 (en)
JP (1) JP2006508030A (en)
KR (1) KR20050036911A (en)
CN (1) CN100491358C (en)
AR (1) AR039985A1 (en)
AU (1) AU2003223786A1 (en)
BR (1) BR0309892A2 (en)
CA (1) CA2485148A1 (en)
IL (2) IL165046A0 (en)
IS (1) IS7520A (en)
MX (1) MXPA04011074A (en)
MY (1) MY140767A (en)
NO (1) NO20045043L (en)
NZ (1) NZ537076A (en)
PL (1) PL373412A1 (en)
RU (1) RU2004135554A (en)
TW (1) TW200406387A (en)
WO (1) WO2003094839A2 (en)
ZA (1) ZA200409881B (en)

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