WO2003095973A3 - Nanoparticle probes with raman spectroscopic fingerprints for analyte detection - Google Patents

Nanoparticle probes with raman spectroscopic fingerprints for analyte detection Download PDF

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Publication number
WO2003095973A3
WO2003095973A3 PCT/US2003/014100 US0314100W WO03095973A3 WO 2003095973 A3 WO2003095973 A3 WO 2003095973A3 US 0314100 W US0314100 W US 0314100W WO 03095973 A3 WO03095973 A3 WO 03095973A3
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WO
WIPO (PCT)
Prior art keywords
reagents
raman
specific binding
probes
detection
Prior art date
Application number
PCT/US2003/014100
Other languages
French (fr)
Other versions
WO2003095973A2 (en
Inventor
Chad Mirkin
Yun-Wei Cao
Rongchao Jin
Original Assignee
Univ Northwestern
Chad Mirkin
Yun-Wei Cao
Rongchao Jin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Northwestern, Chad Mirkin, Yun-Wei Cao, Rongchao Jin filed Critical Univ Northwestern
Priority to AT03736550T priority Critical patent/ATE515698T1/en
Priority to EP03736550A priority patent/EP1499889B1/en
Priority to JP2004503919A priority patent/JP2005524849A/en
Priority to CA2483697A priority patent/CA2483697C/en
Priority to AU2003237180A priority patent/AU2003237180B2/en
Publication of WO2003095973A2 publication Critical patent/WO2003095973A2/en
Publication of WO2003095973A3 publication Critical patent/WO2003095973A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/583—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with non-fluorescent dye label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The invention encompasses reagents comprising particles with at least one Raman dye and a specific binding members bound thereto and methods of using such reagents. The invention also encompasses reagents of a specific binding member and two or more different Raman dyes and methods for using such reagents. New types of particle probes having a specific binding member bound thereto are described. These reagents are used in a novel detection strategy that utilizes the catalytic properties of the Au nanoparticles to generate a silver coating that can behave as a surface-enhanced Raman scattering (SERS) promoter for the dye-labeled particles that have been captured by target and an underlying chip in microarray format. The strategy provides the high sensitivity and high selectivity attributes of grey-scale scanometric detection but provides a route to multiplexing and ratioing capabilities since a very large number of probes can be designed based upon the concept of using a Raman tag as a spectroscopic fingerprint in detection. These spectra are used as fingerprints to differentiate oligonucleotide or other targets in one solution. This method has been used to distinguish six dissimilar DNA targets with six Raman labeled nanoparticle probes, and also two RNA targets with single nucleotide polymorphisms (SNPs).
PCT/US2003/014100 2002-05-07 2003-05-07 Nanoparticle probes with raman spectroscopic fingerprints for analyte detection WO2003095973A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AT03736550T ATE515698T1 (en) 2002-05-07 2003-05-07 NANOPARTICLE PROBE WITH RAMAN SPECTROSCOPIC FINGERPRINTS FOR ANALYTE DETECTION
EP03736550A EP1499889B1 (en) 2002-05-07 2003-05-07 Nanoparticle probes with raman spectroscopic fingerprints for analyte detection
JP2004503919A JP2005524849A (en) 2002-05-07 2003-05-07 Nanoparticle probes for analyte detection with fingerprints for Raman spectroscopy
CA2483697A CA2483697C (en) 2002-05-07 2003-05-07 Nanoparticle probes with raman spectroscopic fingerprints for analyte detection
AU2003237180A AU2003237180B2 (en) 2002-05-07 2003-05-07 Nanoparticle probes with raman spectroscopic fingerprints for analyte detection

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US37853802P 2002-05-07 2002-05-07
US60/378,538 2002-05-07
US38363002P 2002-05-28 2002-05-28
US60/383,630 2002-05-28
US10/172,428 US20030211488A1 (en) 2002-05-07 2002-06-14 Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
US10/172,428 2002-06-14

Publications (2)

Publication Number Publication Date
WO2003095973A2 WO2003095973A2 (en) 2003-11-20
WO2003095973A3 true WO2003095973A3 (en) 2004-07-22

Family

ID=29407691

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/014100 WO2003095973A2 (en) 2002-05-07 2003-05-07 Nanoparticle probes with raman spectroscopic fingerprints for analyte detection

Country Status (7)

Country Link
US (2) US20030211488A1 (en)
EP (1) EP1499889B1 (en)
JP (1) JP2005524849A (en)
AT (1) ATE515698T1 (en)
AU (1) AU2003237180B2 (en)
CA (1) CA2483697C (en)
WO (1) WO2003095973A2 (en)

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