WO2003097162A3 - Enhanced focused ultrasound ablation using microbubbles - Google Patents

Enhanced focused ultrasound ablation using microbubbles Download PDF

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Publication number
WO2003097162A3
WO2003097162A3 PCT/US2003/007471 US0307471W WO03097162A3 WO 2003097162 A3 WO2003097162 A3 WO 2003097162A3 US 0307471 W US0307471 W US 0307471W WO 03097162 A3 WO03097162 A3 WO 03097162A3
Authority
WO
WIPO (PCT)
Prior art keywords
microbubbles
tissue
transducer
target region
focused ultrasound
Prior art date
Application number
PCT/US2003/007471
Other languages
French (fr)
Other versions
WO2003097162A2 (en
Inventor
Kobi Vortman
Shuki Vitek
Kullervo Hynynen
Original Assignee
Insightec Txsonics Ltd
Brigham & Womens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insightec Txsonics Ltd, Brigham & Womens Hospital filed Critical Insightec Txsonics Ltd
Priority to AU2003259024A priority Critical patent/AU2003259024A1/en
Publication of WO2003097162A2 publication Critical patent/WO2003097162A2/en
Publication of WO2003097162A3 publication Critical patent/WO2003097162A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia

Abstract

A system for performing a therapeutic procedure using focused ultrasound includes a piezoelectric transducer, drive circuitry coupled to the transducer for providing drive signals to the transducer, and a controller coupled to the drive circuitry for alternating an intensity of the drive signals between a plurality of intensities. Acoustic energy above a threshold intensity is transmitted by the transducer towards a target region to generate microbubbles in tissue within the target region. The intensity of the acoustic energy is reduced to discontinue generating microbubbles and heat the tissue, e.g., to necrose the tissue, without collapsing the generated microbubbles, the microbubbles enhancing the ability of the tissue in the target region to absorb the acoustic energy.
PCT/US2003/007471 2002-03-27 2003-03-12 Enhanced focused ultrasound ablation using microbubbles WO2003097162A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003259024A AU2003259024A1 (en) 2002-03-27 2003-03-12 Enhanced focused ultrasound ablation using microbubbles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/112,252 US20030187371A1 (en) 2002-03-27 2002-03-27 Systems and methods for enhanced focused ultrasound ablation using microbubbles
US10/112,252 2002-03-27

Publications (2)

Publication Number Publication Date
WO2003097162A2 WO2003097162A2 (en) 2003-11-27
WO2003097162A3 true WO2003097162A3 (en) 2004-07-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/007471 WO2003097162A2 (en) 2002-03-27 2003-03-12 Enhanced focused ultrasound ablation using microbubbles

Country Status (3)

Country Link
US (1) US20030187371A1 (en)
AU (1) AU2003259024A1 (en)
WO (1) WO2003097162A2 (en)

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US9433383B2 (en) 2014-03-18 2016-09-06 Monteris Medical Corporation Image-guided therapy of a tissue
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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9333038B2 (en) 2000-06-15 2016-05-10 Monteris Medical Corporation Hyperthermia treatment and probe therefore
US9387042B2 (en) 2000-06-15 2016-07-12 Monteris Medical Corporation Hyperthermia treatment and probe therefor
US8979871B2 (en) 2009-08-13 2015-03-17 Monteris Medical Corporation Image-guided therapy of a tissue
US9211157B2 (en) 2009-08-13 2015-12-15 Monteris Medical Corporation Probe driver
US9271794B2 (en) 2009-08-13 2016-03-01 Monteris Medical Corporation Monitoring and noise masking of thermal therapy
US9510909B2 (en) 2009-08-13 2016-12-06 Monteris Medical Corporation Image-guide therapy of a tissue
US9177543B2 (en) 2009-08-26 2015-11-03 Insightec Ltd. Asymmetric ultrasound phased-array transducer for dynamic beam steering to ablate tissues in MRI
US9433383B2 (en) 2014-03-18 2016-09-06 Monteris Medical Corporation Image-guided therapy of a tissue
US9486170B2 (en) 2014-03-18 2016-11-08 Monteris Medical Corporation Image-guided therapy of a tissue
US9492121B2 (en) 2014-03-18 2016-11-15 Monteris Medical Corporation Image-guided therapy of a tissue
US9504484B2 (en) 2014-03-18 2016-11-29 Monteris Medical Corporation Image-guided therapy of a tissue

Also Published As

Publication number Publication date
AU2003259024A8 (en) 2003-12-02
US20030187371A1 (en) 2003-10-02
AU2003259024A1 (en) 2003-12-02
WO2003097162A2 (en) 2003-11-27

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