WO2003100026A3 - Methods, compositions, and growth and differentiation factors for insulin-producing cells - Google Patents

Methods, compositions, and growth and differentiation factors for insulin-producing cells Download PDF

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Publication number
WO2003100026A3
WO2003100026A3 PCT/US2003/016734 US0316734W WO03100026A3 WO 2003100026 A3 WO2003100026 A3 WO 2003100026A3 US 0316734 W US0316734 W US 0316734W WO 03100026 A3 WO03100026 A3 WO 03100026A3
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WO
WIPO (PCT)
Prior art keywords
cells
producing cells
hormone
insulin
producing
Prior art date
Application number
PCT/US2003/016734
Other languages
French (fr)
Other versions
WO2003100026A2 (en
Inventor
David Scharp
Original Assignee
Novocell Inc
Becton Dickinson Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novocell Inc, Becton Dickinson Co filed Critical Novocell Inc
Priority to EP03731406A priority Critical patent/EP1507552A2/en
Priority to CA002487858A priority patent/CA2487858A1/en
Priority to JP2004508268A priority patent/JP2006506047A/en
Priority to AU2003240810A priority patent/AU2003240810A1/en
Priority to BRPI0311362-0A priority patent/BR0311362A/en
Publication of WO2003100026A2 publication Critical patent/WO2003100026A2/en
Publication of WO2003100026A3 publication Critical patent/WO2003100026A3/en

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Abstract

A method of converting differentiated non-hormone producing pancreatic cells into differentiated hormone producing cells is disclosed. The method comprises two steps: first, culturing cells under conditions which convert differentiated non-hormone producing cells into stem cells; and second, culturing stem cells under conditions which provide for differentiating stem cells into hormone-producing cells. The invention defines growth and differentiation factors that are presented to the stem cells to result in their differentiation into hormone-producing cells, especially insulin-producing cells. The invention provides a new source of large quantities of hormone producing cells such as insulin-producing cells that are not currently available for therapeutic uses such as the treatment of diabetes.
PCT/US2003/016734 2002-05-28 2003-05-28 Methods, compositions, and growth and differentiation factors for insulin-producing cells WO2003100026A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP03731406A EP1507552A2 (en) 2002-05-28 2003-05-28 Methods, compositions, and growth and differentiation factors for insulin-producing cells
CA002487858A CA2487858A1 (en) 2002-05-28 2003-05-28 Methods, compositions, and growth and differentiation factors for insulin-producing cells
JP2004508268A JP2006506047A (en) 2002-05-28 2003-05-28 Methods, components and growth and differentiation factors for insulin producing cells
AU2003240810A AU2003240810A1 (en) 2002-05-28 2003-05-28 Methods, compositions, and growth and differentiation factors for insulin-producing cells
BRPI0311362-0A BR0311362A (en) 2002-05-28 2003-05-28 methods, compositions and growth and differentiation factors for producing insulin producing cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38400002P 2002-05-28 2002-05-28
US60/384,000 2002-05-28
US44373303A 2003-05-22 2003-05-22
US10/443,733 2003-05-22

Publications (2)

Publication Number Publication Date
WO2003100026A2 WO2003100026A2 (en) 2003-12-04
WO2003100026A3 true WO2003100026A3 (en) 2004-11-04

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EP (1) EP1507552A2 (en)
JP (1) JP2006506047A (en)
CN (1) CN1668324A (en)
AU (1) AU2003240810A1 (en)
BR (1) BR0311362A (en)
CA (1) CA2487858A1 (en)
WO (1) WO2003100026A2 (en)

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US9132226B2 (en) 2008-11-14 2015-09-15 Viacyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells

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CN100549163C (en) 2002-12-16 2009-10-14 技术研究及发展基金有限公司 The stem cell culture for preparing the method for no feeder cell, no allogenic human embryo stem cell and use this method preparation
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
MX2009009225A (en) 2003-12-23 2009-09-28 Cythera Inc Definitive endoderm.
WO2007059007A2 (en) 2005-11-14 2007-05-24 Cythera, Inc. Markers of definitive endoderm
EP2377922B1 (en) * 2004-04-27 2020-04-08 Viacyte, Inc. PDX1 expressing endoderm
WO2006001471A1 (en) * 2004-06-29 2006-01-05 The University Of Tokyo Medicinal composition for promoting glucose-responsive insulin secretion
CA2966883A1 (en) * 2004-07-09 2006-02-16 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
EP1791952A4 (en) 2004-08-13 2008-06-11 Univ Georgia Res Found Compositions and methods for self-renewal and differentiation in human embryonic stem cells
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