WO2003102160A3 - Rationally designed polysaccharide lyases derived from chondroitinase b - Google Patents
Rationally designed polysaccharide lyases derived from chondroitinase b Download PDFInfo
- Publication number
- WO2003102160A3 WO2003102160A3 PCT/US2003/017680 US0317680W WO03102160A3 WO 2003102160 A3 WO2003102160 A3 WO 2003102160A3 US 0317680 W US0317680 W US 0317680W WO 03102160 A3 WO03102160 A3 WO 03102160A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chondroitinase
- rationally designed
- polysaccharide lyases
- inhibiting
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE60334220T DE60334220D1 (en) | 2002-06-03 | 2003-06-03 | Rationally Constructed Lyases Derived from Chondroitinase B. |
EP03756399A EP1532241B1 (en) | 2002-06-03 | 2003-06-03 | Rationally designed polysaccharide lyases derived from chondroitinase b |
AU2003243396A AU2003243396A1 (en) | 2002-06-03 | 2003-06-03 | Rationally designed polysaccharide lyases derived from chondroitinase b |
CA002493509A CA2493509C (en) | 2002-06-03 | 2003-06-03 | Rationally designed polysaccharide lyases derived from chondroitinase b |
AT03756399T ATE481478T1 (en) | 2002-06-03 | 2003-06-03 | RATIONALLY DESIGNED LYASES DERIVED FROM CHONDROITINASE B |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38550902P | 2002-06-03 | 2002-06-03 | |
US60/385,509 | 2002-06-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003102160A2 WO2003102160A2 (en) | 2003-12-11 |
WO2003102160A3 true WO2003102160A3 (en) | 2004-09-16 |
Family
ID=29712183
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/017680 WO2003102160A2 (en) | 2002-06-03 | 2003-06-03 | Rationally designed polysaccharide lyases derived from chondroitinase b |
Country Status (7)
Country | Link |
---|---|
US (4) | US6962699B2 (en) |
EP (1) | EP1532241B1 (en) |
AT (1) | ATE481478T1 (en) |
AU (1) | AU2003243396A1 (en) |
CA (1) | CA2493509C (en) |
DE (1) | DE60334220D1 (en) |
WO (1) | WO2003102160A2 (en) |
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US7687479B2 (en) | 2000-09-12 | 2010-03-30 | Massachusetts Institute Of Technology | Methods and producing low molecular weight heparin |
US7709461B2 (en) | 2000-10-18 | 2010-05-04 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
US7842492B2 (en) | 2007-01-05 | 2010-11-30 | Massachusetts Institute Of Technology | Compositions of and methods of using sulfatases from flavobacterium heparinum |
US7939292B2 (en) | 2000-03-08 | 2011-05-10 | Massachusetts Institute Of Technology | Modified heparinase III and methods of sequencing therewith |
US8018231B2 (en) | 2002-05-20 | 2011-09-13 | Massachussetts Institute Of Technology | Method for sequence determination using NMR |
US8529889B2 (en) | 2004-06-29 | 2013-09-10 | Massachusetts Institute Of Technology | Methods and compositions related to the modulation of intercellular junctions |
Families Citing this family (28)
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---|---|---|---|---|
WO2000012726A2 (en) * | 1998-08-27 | 2000-03-09 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase i and ii |
WO2000033764A1 (en) * | 1998-12-04 | 2000-06-15 | Pathak Chandrashekhar P | Biocompatible crosslinked polymers |
EP1190364A2 (en) * | 1999-04-23 | 2002-03-27 | Massachusetts Institute Of Technology | System and method for polymer notation |
JP4416664B2 (en) * | 2002-05-03 | 2010-02-17 | マサチューセッツ・インスティテュート・オブ・テクノロジー | Δ4,5 glycuronidase and use thereof |
EP1575548B1 (en) | 2002-05-04 | 2011-03-09 | Acorda Therapeutics, Inc. | Compositions and methods for promoting neuronal outgrowth |
US6962699B2 (en) * | 2002-06-03 | 2005-11-08 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from chondroitinase B |
AU2003265561A1 (en) * | 2002-08-15 | 2004-03-03 | Acorda Therapeutics, Inc. | Chimeric protein |
JP4606712B2 (en) * | 2003-01-08 | 2011-01-05 | マサチューセッツ インスティテュート オブ テクノロジー | 2-O sulfatase compositions and related methods |
MXPA05012307A (en) * | 2003-05-16 | 2006-07-03 | Acorda Therapeutics Inc | Proteoglycan degrading mutants for treatment of cns. |
MXPA05012305A (en) * | 2003-05-16 | 2006-04-18 | Acorda Therapeutics Inc | Compositions and methods for the treatment of cns injuries. |
US7959914B2 (en) | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
AU2016204464B2 (en) * | 2003-05-16 | 2018-03-22 | Acorda Therapeutics, Inc. | Proteoglycan degrading mutants for treatment of cns |
WO2005000219A2 (en) * | 2003-05-28 | 2005-01-06 | The Board Of Trustees Of The University Of Illinois | Composition for blocking hiv binding to dendritic cells and methods of use thereof |
WO2005087920A2 (en) * | 2004-03-10 | 2005-09-22 | Massachusetts Institute Of Technology | Recombinant chondroitinase abc i and uses thereof |
WO2005110438A2 (en) * | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the intracellular delivery of polysaccharides |
US20060127950A1 (en) | 2004-04-15 | 2006-06-15 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
WO2005111627A2 (en) * | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
AU2005244933B2 (en) | 2004-05-18 | 2011-08-04 | Acorda Therapeutics, Inc. | Methods of purifying chondroitinase and stable formulations thereof |
US20060154894A1 (en) * | 2004-09-15 | 2006-07-13 | Massachusetts Institute Of Technology | Biologically active surfaces and methods of their use |
EP1928490B8 (en) | 2005-09-26 | 2012-10-03 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase abci mutants |
EP2008096A2 (en) * | 2006-04-03 | 2008-12-31 | Massachusetts Institute of Technology | Glycomic patterns for the detection of disease |
US7722864B2 (en) | 2006-10-10 | 2010-05-25 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase ABCI mutants |
WO2009025888A2 (en) | 2007-05-10 | 2009-02-26 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Regulated synthesis of antigen and/or regulated attentuation to enhance vaccine immunogenics and/or safety |
GB0712302D0 (en) * | 2007-06-22 | 2007-08-01 | Cambridge Entpr Ltd | Chrondroitinase polypeptides |
US20090286289A1 (en) * | 2008-03-10 | 2009-11-19 | Pang Danny Z | Production of Hyaluronate Unsaturated Disaccharides and its Application |
US9045742B2 (en) * | 2009-05-29 | 2015-06-02 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant Edwardsiella bacterium |
US9796970B1 (en) | 2017-04-24 | 2017-10-24 | Advantek Serum Laboratories Ltd. | Production of high purity chondroitinase ABC |
CN111593040B (en) * | 2020-06-20 | 2022-08-30 | 山东大学 | Dermatan sulfate lyase and application thereof |
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-
2003
- 2003-06-03 US US10/454,816 patent/US6962699B2/en not_active Expired - Lifetime
- 2003-06-03 AU AU2003243396A patent/AU2003243396A1/en not_active Abandoned
- 2003-06-03 EP EP03756399A patent/EP1532241B1/en not_active Expired - Lifetime
- 2003-06-03 CA CA002493509A patent/CA2493509C/en not_active Expired - Fee Related
- 2003-06-03 WO PCT/US2003/017680 patent/WO2003102160A2/en not_active Application Discontinuation
- 2003-06-03 DE DE60334220T patent/DE60334220D1/en not_active Expired - Lifetime
- 2003-06-03 AT AT03756399T patent/ATE481478T1/en not_active IP Right Cessation
-
2004
- 2004-10-14 US US10/966,671 patent/US7129335B2/en not_active Expired - Lifetime
- 2004-10-14 US US10/967,041 patent/US7105334B2/en not_active Expired - Lifetime
-
2006
- 2006-09-08 US US11/518,389 patent/US20070065424A1/en not_active Abandoned
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Non-Patent Citations (3)
Title |
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HAUNG ET AL: "Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis", BIOCHEMISTRY, vol. 40, no. 8, 2001, pages 2359 - 2372, XP002978618 * |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7939292B2 (en) | 2000-03-08 | 2011-05-10 | Massachusetts Institute Of Technology | Modified heparinase III and methods of sequencing therewith |
US7687479B2 (en) | 2000-09-12 | 2010-03-30 | Massachusetts Institute Of Technology | Methods and producing low molecular weight heparin |
US7709461B2 (en) | 2000-10-18 | 2010-05-04 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
US8018231B2 (en) | 2002-05-20 | 2011-09-13 | Massachussetts Institute Of Technology | Method for sequence determination using NMR |
US8529889B2 (en) | 2004-06-29 | 2013-09-10 | Massachusetts Institute Of Technology | Methods and compositions related to the modulation of intercellular junctions |
US7842492B2 (en) | 2007-01-05 | 2010-11-30 | Massachusetts Institute Of Technology | Compositions of and methods of using sulfatases from flavobacterium heparinum |
US8846363B2 (en) | 2007-01-05 | 2014-09-30 | James R. Myette | Compositions of and methods of using sulfatases from Flavobacterium heparinum |
Also Published As
Publication number | Publication date |
---|---|
EP1532241A4 (en) | 2005-12-14 |
US20070065424A1 (en) | 2007-03-22 |
DE60334220D1 (en) | 2010-10-28 |
EP1532241A2 (en) | 2005-05-25 |
AU2003243396A8 (en) | 2003-12-19 |
CA2493509C (en) | 2010-03-09 |
EP1532241B1 (en) | 2010-09-15 |
US7129335B2 (en) | 2006-10-31 |
AU2003243396A1 (en) | 2003-12-19 |
CA2493509A1 (en) | 2003-12-11 |
WO2003102160A2 (en) | 2003-12-11 |
US20040091472A1 (en) | 2004-05-13 |
US20050227320A1 (en) | 2005-10-13 |
US6962699B2 (en) | 2005-11-08 |
ATE481478T1 (en) | 2010-10-15 |
US20050233419A1 (en) | 2005-10-20 |
US7105334B2 (en) | 2006-09-12 |
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