WO2003105908B1 - Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs - Google Patents

Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs

Info

Publication number
WO2003105908B1
WO2003105908B1 PCT/US2003/007934 US0307934W WO03105908B1 WO 2003105908 B1 WO2003105908 B1 WO 2003105908B1 US 0307934 W US0307934 W US 0307934W WO 03105908 B1 WO03105908 B1 WO 03105908B1
Authority
WO
WIPO (PCT)
Prior art keywords
cell
mammal
administering
orosomucoid
glycoconjugate
Prior art date
Application number
PCT/US2003/007934
Other languages
French (fr)
Other versions
WO2003105908A3 (en
WO2003105908A2 (en
WO2003105908A9 (en
Inventor
Catherine A Phillips
Original Assignee
Dep Veterans Affairs Rehab R&D
Catherine A Phillips
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2003267949A priority Critical patent/AU2003267949A1/en
Application filed by Dep Veterans Affairs Rehab R&D, Catherine A Phillips filed Critical Dep Veterans Affairs Rehab R&D
Priority to KR10-2004-7014544A priority patent/KR20050013531A/en
Priority to JP2004512808A priority patent/JP2006501169A/en
Priority to EP03748896A priority patent/EP1499347A2/en
Priority to IL16407903A priority patent/IL164079A0/en
Priority to CA002479309A priority patent/CA2479309A1/en
Publication of WO2003105908A2 publication Critical patent/WO2003105908A2/en
Publication of WO2003105908A9 publication Critical patent/WO2003105908A9/en
Publication of WO2003105908A3 publication Critical patent/WO2003105908A3/en
Publication of WO2003105908B1 publication Critical patent/WO2003105908B1/en
Priority to US10/940,691 priority patent/US20070110734A9/en
Priority to HK06100051.0A priority patent/HK1079987A1/en
Priority to AU2009201808A priority patent/AU2009201808A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1741—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals alpha-Glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

The present invention is directed to methods for delivering cells to a target tissue in a mammal using glycoconjugate to traffic the cell to a desired organ in the mammal. The methods according to the present invention are especially applicable to administering lymphoid cells such as natural killer (NK) cells activated with interleukin-2 (IL-2), lymphokine-activated killer (LAK) cells and/or tumor-infiltrating lymphocytes (TILs) and/or cytotoxic lymphocytes (CTLs), or stem cells such as those derived from the bone marrow or from umbilical cord tissue. The methods are also useful for targeting a gene of interest to a tissue in a mammal by introducing a cell containing the gene of interest and administering a glycoconjugate to the mammal.

Claims

53AMENDED CLAIMS[Received by the International Bureau on 29 October 2004 (29.10.04): original claims 2-23, 25-28, 30-33, 35-43 and 49 unchanged; claims 1, 24, 29, 34, 44, 48 and 50 amended; new claims 51-57 added (7 pages)]
1. A method for delivering a stem cell or lymphoid cell to a target tissue in a mammal comprising the steps of:
(a) administering a glycoconjugate to a mammal; and
(b) administering the cell to the mammal.
2. The method of claim 1, wherein the cell is a hematopoietic stem cell.
3. The method of claim 2, wherein the stem cell is obtained from the bone marrow, placenta, muscle, fat or an umbilical cord.
4. The method of claim 1 wherein the lymphoid cell is selected from the group consisting of a natural killer (NK) cell, a lymphokine-activated killer (LAK) cell, a tumor- infiltrating lymphocyte (TTL), a cytotoxic lymphocyte (CTL), and mixtures thereof.
5. The method of claim 1, wherein the glycoconjugate is represented by the general formula P-(S)x-Gal, wherein P is a peptide residue of a human serum glycoprotein and S is a sugar residue of a human serum glycoprotein; x is an integer from 1 to 100 and Gal is galactose residue,
6. The method of claim 1, wherein the glycoconjugate is selected from the group consisting of an orosomucoid and an asialoorosomucoid.
7. The method of claim 1, wherein the target tissue is a tissue of an organ selected from the group consisting of the heart, the liver, the lungs, and the kidneys. 54
8. The method of claim 1, wherein the glycoconjugate is administered to the mammal prior to the cell.
9. The method of claim 1, wherein the glycoconjugate and the cell are administered intravenously to the mammal.
10. A method for targeting a hematopoietic stem cell to the heart of a mammal comprising the steps of:
(a) administering an asialo-orosomucoid lo the mammal; and
(b) administering the cell to the mammal.
11. The method of claim 10, wherein the cell is administered after the step of administering the asialo-orosomucoid.
12. The method of claim 10, wherein the asialo-orosomucoid is administered via a vessel proximal to the heart.
13. The method of claim 12 wherein the asialo-orosomucoid is administered via a jugular vein.
14. The method of claim 10 wherein the heart of a mammal has suffered ischemic injury prior to administering the asialo-orosomucoid.
15. A method for targeting a mesenchymal stem cell to the heart of a mammal comprising the steps of:
(a) administering an orosomucoid to the mammal; and
(b) administering the cell to the mammal. 55
16. The method of claim 15, wherein the orosomucoid is administered via a vessel proximal to the heart.
17 Thf. method of claim 16 wherein the orosomucoid is administered via a iugular vein.
18. The method of claim 15 wherein the heart of a mammal has suffered ischemic injury prior to administering the orosomucoid.
19. The method of claim 15, wherein the cell is administered after the step of administering the orosomucoid.
20. A method for targeting a hematopoietic stem cell to the liver of a mammal comprising the steps of:
(a) administering an orosomucoid to the mammal; and
(b) administering the cell to the mammal.
21. The method of claim 20, wherein the cell is administered after the step of administering the orosomucoid.
22. A method for targeting a mesenchymal stem cell to the liver of a mammal comprising the steps of:
(a) administering an asialoorosornucoid to the mammal; and
(b) administering the cell to the mammal,
23. The method of claim 22, wherein the cell is administered after the step of administering the orosomucoid. 56
24. A method for targeting a gene of interest to a tissue in a mammal, said method comprising the steps of:
(a) introducing a cell comprising the gene of interest to the mammal; and
(b) administering a glycoconjugate.
25. The method of claim 24, wherein the cell is a hematopoietic stem cell.
26. The method of claim 24, wherein the cell is a lymphoid cell.
27. The method of claim 26, wherein the stem cell is obtained from the bone marrow, peripheral circulation or an umbilical cord.
28. The method of claim 24, wherein the glycoconjugate is selected from the group consisting of an orosomucoid and an asialoorosomucoid.
29. A method for treating a disease characterized by tissue damage in a mammal comprising the steps of;
(a) administering a stem cell to the mammal; and
(b) administering a glycoconjugate to the mammal.
30. The method of claim 29, wherein the stem cell is obtained from the hone marrow, peripheral circulation or an umbilical cord.
31. The method of claim 29, wherein the glycoconjugate is selected from the group consisting of an orosomucoid and an asialoorosomucoid.
32. The method of claim 29, wherein the disease is selected from the group consisting of a heart disease, a lung disease, a liver disease, a neurological disease and a kidney disease.
33. The method of claim 29, wherein the disease is selected from the group consisting of myocardial infarction, emphysema, cystic fibrosis, hepatitis, stroke, nephritis and microalbuminuri .
34. A pharmaceutical composition comprising a normal lymphoid cell or a stem cell and a glycoconjugate, wherein said glycoconjugate is a human serum glycoprotein.
35. The pharmaceutical composition of claim 34, wherein the glycoconjugate is selected from the group consisting of an orosomucoid and an asialoorosomucoid.
36. The pharmaceutical composition of claim 34, wherein the cell is a stem cell.
37. The pharmaceutical composition of claim 34, wherein the cell is a lymphoid cell.
38. An article of manufacture, comprising packaging material and a pharmaceutical composition contained within the packaging material, wherein the pharmaceutical composition comprises a glycoconjugate that is therapeutically effective for targeting a cell to a desired organ, and wherein the packaging material comprises a label which indicates that the pharmaceutical composition can be used for targeting a cell to a desired organ.
39. The article of manufacture of claim 38, further comprising additional reagents for making cell suspensions to be administered to a mammal and printed instructions, for use in targeting cells.
40. The article of manufacture of claim 39 further comprising a quantity of stem cells suitable for targeting of such cells in a mammal. 58
41. The article of manufacture of claim 38, wherein the glycoconjugate is selected from the group consisting of an orosomucoid and an asialoorosomucoid.
42. The article of manufacture of claim 40, wherein the cell is a hematopoietic stem cell.
-13, A mothod to improve the efficiency of an adoptive immunothcrapy using a lymphoid cell comprising modification of sialoglycoprotein determinants on the lymphoid cell surface.
44. The method of claim 43 wherein the modification comprises removal of sialic acid to generate new asialoglycoprotein deteπninants.
45. The method of claim 44 wherein the modification comprises removal of sialic acid by an enzyme.
46. The method of claim 45 wherein the modification comprises removal of sialic acid by a neuraminidase,
47. The method of claim 43 wherein the modification comprises addition of sialic acid by an enzyme.
48. The method of claim 43 wherein the adoptive immunotherapy is for a liver metastasis or a primary liver tumor and said method comprises regional administration to the liver of activated lymphocytes.
59
49. The method of claim 6 wherein the glycoconjugate is administered via a vessel proximal to the organ wherein the target tissue is located.
50. The method of claim 6 wherein the organ is the liver and the glycoconjugate is administered via the hepatic artery or portal vein or peripheral vein.
51. The method of claim 24 wherein the gene of interest comprises a transgene.
52. A method for delivering a stem cell to a target tissue in a mammal comprising the steps of:
(a) modifying sialoglycoprotein determinants on the cell surface; and
(b) administering the cell to the mammal.
53. The method of claim 52 wherein the modification comprises removal of sialic acid to generate new asialoglycoprotein determinants.
54. The method of claim 53 wherein the modification comprises removal of sialic acid by an enzyme.
55. The method of claim 54 wherein the modification comprises removal of sialic acid by a neura inidase.
56. The method of claim 52 wherein the modification comprises addition of sialic acid by an enzyme.
57. The method of claim 52 wherein the mammal has a disease characterized by a deficiency in a gene product and the stem cell comprises a functional gene encoding that gene product.
PCT/US2003/007934 2002-03-15 2003-03-14 Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs WO2003105908A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CA002479309A CA2479309A1 (en) 2002-03-15 2003-03-14 Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
KR10-2004-7014544A KR20050013531A (en) 2002-03-15 2003-03-14 Methods and Compositions Using Cellular Asialodeterminants and Glycoconjugates for Targeting Cells to Tissues and Organs
JP2004512808A JP2006501169A (en) 2002-03-15 2003-03-14 Methods and compositions for targeting cells to tissues and organs using cellular asialo determinants and glycoconjugates
EP03748896A EP1499347A2 (en) 2002-03-15 2003-03-14 Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
IL16407903A IL164079A0 (en) 2002-03-15 2003-03-14 Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
AU2003267949A AU2003267949A1 (en) 2002-03-15 2003-03-14 Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
US10/940,691 US20070110734A9 (en) 2002-03-15 2005-02-01 Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
HK06100051.0A HK1079987A1 (en) 2002-03-15 2006-01-04 Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
AU2009201808A AU2009201808A1 (en) 2002-03-15 2009-05-06 Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36449802P 2002-03-15 2002-03-15
US60/364,498 2002-03-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/940,691 Continuation US20070110734A9 (en) 2002-03-15 2005-02-01 Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs

Publications (4)

Publication Number Publication Date
WO2003105908A2 WO2003105908A2 (en) 2003-12-24
WO2003105908A9 WO2003105908A9 (en) 2004-03-04
WO2003105908A3 WO2003105908A3 (en) 2004-10-28
WO2003105908B1 true WO2003105908B1 (en) 2004-12-16

Family

ID=28041926

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2003/007934 WO2003105908A2 (en) 2002-03-15 2003-03-14 Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
PCT/US2003/007836 WO2003077865A2 (en) 2002-03-15 2003-03-14 Methods and compositions for directing cells to target organs
PCT/US2003/007834 WO2003077864A2 (en) 2002-03-15 2003-03-14 Methods and compositions for directing cells to target organs

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US2003/007836 WO2003077865A2 (en) 2002-03-15 2003-03-14 Methods and compositions for directing cells to target organs
PCT/US2003/007834 WO2003077864A2 (en) 2002-03-15 2003-03-14 Methods and compositions for directing cells to target organs

Country Status (10)

Country Link
US (8) US7282222B2 (en)
EP (1) EP1499347A2 (en)
JP (1) JP2006501169A (en)
KR (1) KR20050013531A (en)
CN (1) CN100579577C (en)
AU (4) AU2003267949A1 (en)
CA (1) CA2479309A1 (en)
HK (1) HK1079987A1 (en)
IL (1) IL164079A0 (en)
WO (3) WO2003105908A2 (en)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
CA2430989A1 (en) 2000-12-06 2002-06-13 Robert J. Hariri Method of collecting placental stem cells
EP2316919B1 (en) * 2001-02-14 2015-10-07 Anthrogenesis Corporation Post-partum mammalian placenta, its use and placental stem cells therefrom
WO2002063962A1 (en) * 2001-02-14 2002-08-22 Hariri Robert J Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
AU2003267949A1 (en) * 2002-03-15 2003-12-31 U.S. Government As Represented By The Department Of Veterans Affairs Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
US7576186B2 (en) * 2002-04-23 2009-08-18 Roger Williams Hospital Compositions and methods for stem cell delivery
US9321992B2 (en) * 2002-06-14 2016-04-26 Case Western Reserve University Cell targeting methods and compositions
US20050271639A1 (en) * 2002-08-22 2005-12-08 Penn Marc S Genetically engineered cells for therapeutic applications
CN1711475A (en) * 2002-10-10 2005-12-21 退伍军人事务部 Detection, localization and staging of tumors using labeled activated lymphocytes directed to a tumor specific epitope
KR101042448B1 (en) 2002-11-26 2011-06-16 안트로제네시스 코포레이션 Cytotherapeutics, cytotherapeutic units and methods for treatments using them
WO2004084950A2 (en) * 2003-03-24 2004-10-07 Case Western Reserve University Cell targeting methods and compositions
US8603462B2 (en) 2003-04-01 2013-12-10 University Of Utah Research Foundation Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction
EP2298861B1 (en) 2004-03-22 2017-09-13 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
JP2008515434A (en) * 2004-10-08 2008-05-15 ジョージア テック リサーチ コーポレイション Microencapsulation of cells in hydrogels using electrostatic potential
FI20055398A0 (en) 2005-07-08 2005-07-08 Suomen Punainen Risti Veripalv Method for evaluating cell populations
NZ597304A (en) 2005-10-13 2013-06-28 Anthrogenesis Corp Immunomodulation using placental stem cells
AU2006332679A1 (en) 2005-12-29 2007-07-12 Anthrogenesis Corporation Co-culture of placental stem cells and stem cells from a second source
JP5550235B2 (en) 2005-12-29 2014-07-16 アントフロゲネシス コーポレーション Placental stem cell population
US20070178073A1 (en) * 2006-02-01 2007-08-02 Samsung Life Public Welfare Foundation Composition Comprising Separated or Proliferated Cells from Umbilical Cord Blood for Treating Developmental and/or Chronic Lung Disease
EP2422794A3 (en) 2006-03-07 2013-03-13 Geeta Shroff Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
US7959949B2 (en) 2006-04-27 2011-06-14 University Of Central Florida Research Foundation, Inc. Functionalized nanoceria composition for ophthalmic treatment
WO2008073748A1 (en) * 2006-12-08 2008-06-19 University Of Rochester Expansion of hematopoietic stem cells
CA2672998C (en) 2007-01-02 2013-08-06 University Of Central Florida Research Foundation, Inc. Methods and materials for stimulating proliferation of stem cells
FI20075030A0 (en) 2007-01-18 2007-01-18 Suomen Punainen Risti Veripalv Method of modifying cells
US20090104160A1 (en) * 2007-02-01 2009-04-23 Moraga Biotechnology Corporation Mobilization of Stem Cells After Trauma and Methods Therefor
CN103356711A (en) 2007-02-12 2013-10-23 人类起源公司 Immunomodulation using placental stem cells
EP2142206B1 (en) 2007-03-30 2014-07-30 The Cleveland Clinic Foundation SDF-1 for use in the treatment of ischemic peripheral vascular disorders
US8574567B2 (en) 2007-05-03 2013-11-05 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
EP2155860B1 (en) 2007-05-03 2014-08-27 The Brigham and Women's Hospital, Inc. Multipotent stem cells and uses thereof
US9119391B1 (en) 2007-07-16 2015-09-01 University Of Central Florida Research Foundation, Inc. Polymer coated ceria nanoparticles for selective cytoprotection
WO2009037690A1 (en) * 2007-09-19 2009-03-26 Pluristem Ltd. Adherent cells from adipose or placenta tissues and use thereof in therapy
AU2008307633C1 (en) 2007-09-28 2015-04-30 Celularity Inc. Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
US8142759B2 (en) * 2007-12-12 2012-03-27 Institute Of Nuclear Energy Research Glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent thereof
CA2709398C (en) 2007-12-14 2017-11-07 The Cleveland Clinic Foundation Use of stromal cell-derived factor 1 for promoting wound healing
US20090246179A1 (en) * 2008-02-11 2009-10-01 The Cleveland Clinic Foundation Method of treating myocardial injury
WO2009132277A1 (en) * 2008-04-25 2009-10-29 The Board Of Regents Of The University Of Oklahoma Inhibition of neovascularization by cerium oxide nanoparticles
US8916199B1 (en) 2008-04-25 2014-12-23 University of Central Florida Research Foundation, Ind. Inhibition of angiogenesis associated with ovarian cancer by nanoparticles of cerium oxide
EP2166085A1 (en) 2008-07-16 2010-03-24 Suomen Punainen Risti Veripalvelu Divalent modified cells
US9127202B1 (en) 2008-07-18 2015-09-08 University Of Central Florida Research Foundation, Inc. Biocompatible nano rare earth oxide upconverters for imaging and therapeutics
KR20180108887A (en) 2008-08-20 2018-10-04 안트로제네시스 코포레이션 Treatment of stroke using isolated placental cells
JP6169316B2 (en) 2008-08-20 2017-07-26 アンスロジェネシス コーポレーション Improved cell composition and method for producing the same
MX2011001992A (en) 2008-08-22 2011-03-29 Anthrogenesis Corp Methods and compositions for treatment of bone defects with placental cell populations.
SG190659A1 (en) 2008-09-02 2013-06-28 Pluristem Ltd Adherent cells from placenta tissue and use thereof in therapy
RU2562154C2 (en) 2008-11-19 2015-09-10 Антродженезис Корпорейшн Amniotic adhesive cells
US10328103B2 (en) 2009-01-03 2019-06-25 Ray C. Wasielewski Medical treatment composition comprising mammalian dental pulp stem cells
US8470308B2 (en) * 2009-01-03 2013-06-25 Ray C. Wasielewski Enhanced medical implant comprising disrupted tooth pulp and tooth particles
US8883519B1 (en) 2009-03-17 2014-11-11 University Of Central Florida Research Foundation, Inc. Oxidase activity of polymeric coated cerium oxide nanoparticles
US9585840B1 (en) 2009-07-10 2017-03-07 University Of Central Florida Research Foundation, Inc. Redox active cerium oxide nanoparticles and associated methods
JP5856059B2 (en) 2009-08-28 2016-02-09 ザ クリーブランド クリニック ファウンデーション SDF-1 delivery for treating ischemic tissue
US8795731B1 (en) 2009-10-12 2014-08-05 University Of Central Florida Research Foundation, Inc. Cerium oxide nanoparticle-based device for the detection of reactive oxygen species and monitoring of chronic inflammation
ES2646750T3 (en) 2010-01-26 2017-12-15 Anthrogenesis Corporation Treatment of bone-related cancers using placental stem cells
WO2011102890A1 (en) * 2010-02-18 2011-08-25 Albert Einstein College Of Medicine Of Yeshiva University Methods of treatment of hemophilia
KR20190076060A (en) 2010-04-07 2019-07-01 안트로제네시스 코포레이션 Angiogenesis using placental stem cells
EP2555783A1 (en) 2010-04-08 2013-02-13 Anthrogenesis Corporation Treatment of sarcoidosis using placental stem cells
US20130156773A1 (en) * 2010-06-18 2013-06-20 Women And Infants Hospital Of Rhode Island Lung regeneration using cord blood-derived hematopoietic stem cells
WO2012009422A1 (en) 2010-07-13 2012-01-19 Anthrogenesis Corporation Methods of generating natural killer cells
US10426740B1 (en) 2010-08-18 2019-10-01 Avm Biotechnology, Llc Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues
US8877207B2 (en) 2010-09-17 2014-11-04 University Of Central Florida Research Foundation, Inc. Nanoparticles of cerium oxide targeted to an amyloid-beta antigen of Alzheimer's disease and associated methods
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
WO2012127320A1 (en) 2011-03-22 2012-09-27 Pluristem Ltd. Methods for treating radiation or chemical injury
ES2707579T3 (en) 2011-06-01 2019-04-04 Celularity Inc Pain treatment using placental cytoblast
US8951539B1 (en) 2011-06-07 2015-02-10 University Of Central Florida Research Foundation, Inc. Methods of promoting angiogenesis using cerium oxide nanoparticles
WO2013055476A1 (en) 2011-09-09 2013-04-18 Anthrogenesis Corporation Treatment of amyotrophic lateral sclerosis using placental stem cells
US9161950B2 (en) 2011-09-21 2015-10-20 University Of Central Florida Foundation, Inc. Neuronal protection by cerium oxide nanoparticles
AU2014215458A1 (en) 2013-02-05 2015-08-13 Anthrogenesis Corporation Natural killer cells from placenta
US9463437B2 (en) 2013-02-14 2016-10-11 University Of Central Florida Research Foundation, Inc. Methods for scavenging nitric oxide using cerium oxide nanoparticles
WO2015172659A1 (en) * 2014-05-14 2015-11-19 中国科学院上海生命科学研究院 Uses of il-17 in enhancing immune-suppression function of mesenchymal stem cells
WO2016057649A1 (en) * 2014-10-07 2016-04-14 NuTech Medical, Inc. Mesenchymal stem cell diagnostic testing
JP2018535655A (en) 2015-09-29 2018-12-06 アムジエン・インコーポレーテツド ASGR inhibitor
GB201604304D0 (en) 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
MX2019011679A (en) 2017-04-01 2019-11-01 Avm Biotechnology Llc Replacement of cytotoxic preconditioning before cellular immunotherapy.
EP3488851A1 (en) 2018-10-03 2019-05-29 AVM Biotechnology, LLC Immunoablative therapies
WO2020142727A1 (en) * 2019-01-03 2020-07-09 Palleon Pharmaceuticals Inc. Methods and compositions for treating cancer with immune cells

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4466951A (en) * 1982-11-12 1984-08-21 University Of California Intracellular trapping of therapeutics or tracer agents
JPS61503003A (en) * 1984-04-19 1986-12-25 ユニバ−シテイ−　オブ　クイ−ンスランド Contraceptive methods, contraceptive preparations and contraceptive devices
US4797368A (en) * 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5776093A (en) * 1985-07-05 1998-07-07 Immunomedics, Inc. Method for imaging and treating organs and tissues
US4735210A (en) * 1985-07-05 1988-04-05 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US4801533A (en) * 1986-06-25 1989-01-31 Fudenberg H Hugh Method of using alpha-1 acid glycoprotein on T-cells as a marker for alzheimer's disease
US5284646A (en) * 1986-07-03 1994-02-08 Advanced Magnetics Inc. Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents
US5352432A (en) * 1986-07-03 1994-10-04 Advanced Magnetics, Inc. Hepatocyte specific composition and their use as diagnostic imaging agents
US5679323A (en) 1986-07-03 1997-10-21 Advanced Magnetics, Inc. Hepatocyte-specific receptor-mediated endocytosis-type compositions
US5262176A (en) * 1986-07-03 1993-11-16 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids
US5554386A (en) * 1986-07-03 1996-09-10 Advanced Magnetics, Inc. Delivery of therapeutic agents to receptors using polysaccharides
US5342607A (en) * 1986-07-03 1994-08-30 Advanced Magnetics, Inc. Receptor mediated endocytosis type magnetic resonance imaging contrast agents
US5490991A (en) * 1986-07-03 1996-02-13 Advanced Magnetics, Inc. Directed delivery of radioprotectants using a receptor specific carrier
EP0273452B1 (en) 1986-12-30 1994-03-23 Nihon Medi-Physics Co., Ltd. High molecular compound comprising unit of asialoglycoprotein acceptor-directing compound and unit of chelate-forming compound chemically bonded thereto, and its utilisation
US5166320A (en) 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
US5098843A (en) * 1987-06-04 1992-03-24 Calvin Noel M Apparatus for the high efficiency transformation of living cells
US5270199A (en) * 1987-08-20 1993-12-14 The Children's Medical Center Corporation Human mannose-binding protein
US5128257A (en) * 1987-08-31 1992-07-07 Baer Bradford W Electroporation apparatus and process
US4859449A (en) * 1987-09-14 1989-08-22 Center For Molecular Medicine And Immunology Modified antibodies for enhanced hepatocyte clearance
US4970154A (en) * 1987-10-09 1990-11-13 Baylor College Of Medicine Method for inserting foreign genes into cells using pulsed radiofrequency
US5043260A (en) 1987-11-02 1991-08-27 Rhode Island Hospital Perfusion device with hepatocytes
US5057301A (en) * 1988-04-06 1991-10-15 Neorx Corporation Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents
US5399346A (en) * 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
DK0452457T3 (en) 1989-11-03 1998-03-02 Univ Vanderbilt Method for in vivo removal of functional foreign genes
US5279833A (en) * 1990-04-04 1994-01-18 Yale University Liposomal transfection of nucleic acids into animal cells
US5460831A (en) * 1990-06-22 1995-10-24 The Regents Of The University Of California Targeted transfection nanoparticles
US5173414A (en) * 1990-10-30 1992-12-22 Applied Immune Sciences, Inc. Production of recombinant adeno-associated virus vectors
US5837539A (en) * 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
ZA922265B (en) * 1991-03-28 1992-12-30 American Cyanamid Co Somatostatin receptor
US5352670A (en) * 1991-06-10 1994-10-04 Alberta Research Council Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides
KR950014915B1 (en) * 1991-06-19 1995-12-18 주식회사녹십자 Asialoglycoprotein-conjugated compounds
US5254342A (en) * 1991-09-30 1993-10-19 University Of Southern California Compositions and methods for enhanced transepithelial and transendothelial transport or active agents
NZ244306A (en) * 1991-09-30 1995-07-26 Boehringer Ingelheim Int Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation
US5545130A (en) * 1992-04-08 1996-08-13 Genetronics, Inc. Flow through electroporation method
US5587308A (en) 1992-06-02 1996-12-24 The United States Of America As Represented By The Department Of Health & Human Services Modified adeno-associated virus vector capable of expression from a novel promoter
IL105914A0 (en) 1992-06-04 1993-10-20 Univ California Methods and compositions for in vivo gene therapy
US5624896A (en) * 1992-06-09 1997-04-29 Neorx Corporation Clearing agents useful in pretargeting methods
US5608060A (en) 1992-06-09 1997-03-04 Neorx Corporation Biotinidase-resistant biotin-DOTA conjugates
US5616690A (en) * 1992-06-09 1997-04-01 Neorx Corporation Hexose derivatized human serum albumin clearing agents
US5322682A (en) * 1992-08-06 1994-06-21 The Regents Of The University Of California Method for quantitatively measuring and mapping stored iron in tissue using MRI
US5656609A (en) * 1992-09-24 1997-08-12 University Of Connecticut Method of enhancing and/or prolonging expression of gene introduced into a cell using colchicine
ATE244888T1 (en) * 1993-02-05 2003-07-15 Epigen Inc HUMAN CARCINOMA ANTIGEN (HCA), HCA ANTIBODIES, HCA IMMUNOASSAYS, RECORDING METHODS AND THERAPY
US5670361A (en) 1993-05-17 1997-09-23 The Regents Of The University Of California HIV-specific ribozymes
US5525503A (en) * 1993-09-28 1996-06-11 Dana-Farber Cancer Institute, Inc. Signal transduction via CD28
US5527884A (en) * 1993-12-21 1996-06-18 President And Fellows Of Harvard College Mediators of chronic allograft rejection and DNA molecules encoding them
US5728518A (en) * 1994-01-12 1998-03-17 The Immune Response Corporation Antiviral poly-and oligonucleotides
US5728399A (en) 1994-06-29 1998-03-17 University Of Conn. Use of a bacterial component to enhance targeted delivery of polynucleotides to cells
US5512294A (en) * 1994-08-05 1996-04-30 Li; King C. Targeted polymerized liposome contrast agents
US5683866A (en) * 1996-05-09 1997-11-04 Sarkar; Debi P. Process for producing a targeted gene
US6146614A (en) * 1996-07-02 2000-11-14 Massachusetts Institute Of Technology Method for determining lymphocyte distribution and trafficking in mammals using imaging
US5719020A (en) 1996-09-25 1998-02-17 Oklahoma Medical Research Foundation 4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens
US7282220B1 (en) * 1996-11-05 2007-10-16 Hsing-Wen Sung Genipin-crosslinked gelatin microspheres as drug carrier
DE69842060D1 (en) 1997-05-08 2011-01-27 Oncothyreon Inc Method of obtaining activated T cells and antigen-incubated antigen-presenting cells
US6466599B1 (en) * 1999-04-07 2002-10-15 Lambda Physik Ag Discharge unit for a high repetition rate excimer or molecular fluorine laser
AU3923000A (en) * 1999-04-16 2000-11-02 Amgen, Inc. Agp-1 fusion protein compositions and methods
US6406699B1 (en) * 1999-10-05 2002-06-18 Gary W. Wood Composition and method of cancer antigen immunotherapy
AU2003267949A1 (en) 2002-03-15 2003-12-31 U.S. Government As Represented By The Department Of Veterans Affairs Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
CN1711475A (en) * 2002-10-10 2005-12-21 退伍军人事务部 Detection, localization and staging of tumors using labeled activated lymphocytes directed to a tumor specific epitope

Also Published As

Publication number Publication date
IL164079A0 (en) 2005-12-18
US7282222B2 (en) 2007-10-16
AU2003225791A8 (en) 2003-09-29
WO2003105908A3 (en) 2004-10-28
AU2003225793A8 (en) 2003-09-29
CA2479309A1 (en) 2003-12-24
US20060171934A1 (en) 2006-08-03
US20070243174A1 (en) 2007-10-18
US7563459B2 (en) 2009-07-21
US20070243173A1 (en) 2007-10-18
WO2003105908A2 (en) 2003-12-24
JP2006501169A (en) 2006-01-12
WO2003077865A2 (en) 2003-09-25
US20040180040A1 (en) 2004-09-16
US20100047215A1 (en) 2010-02-25
AU2003225791A1 (en) 2003-09-29
WO2003105908A9 (en) 2004-03-04
WO2003077864A2 (en) 2003-09-25
WO2003077865A3 (en) 2004-04-01
US20070196331A1 (en) 2007-08-23
WO2003077864A3 (en) 2004-04-01
AU2003267949A1 (en) 2003-12-31
AU2003225793A1 (en) 2003-09-29
EP1499347A2 (en) 2005-01-26
US20070243175A1 (en) 2007-10-18
US20070248577A1 (en) 2007-10-25
AU2009201808A1 (en) 2009-05-28
US20070110734A9 (en) 2007-05-17
CN1649621A (en) 2005-08-03
CN100579577C (en) 2010-01-13
KR20050013531A (en) 2005-02-04
HK1079987A1 (en) 2006-04-21

Similar Documents

Publication Publication Date Title
WO2003105908B1 (en) Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
Bessler et al. Synthetic lipopeptide analogs of bacterial lipoprotein are potent polyclonal activators for murine B lymphocytes.
EP2750681B1 (en) Branched discrete peg constructs
US10087217B2 (en) Adeno-associated virus with site-directed mutagenesis and site-directed modification and preparation method and application thereof
JP5361988B2 (en) Growth factor-mimicking peptides and uses thereof
EP2455099B1 (en) Method of producing recombinant TAT-HOXB4H protein for use as a stimulant of hematopoiesis in vivo
JPH02502917A (en) Alveolar surfactant protein and related polypeptides
CA2323073A1 (en) Uses for human non-autologous mesenchymal stem cells
WO1997026337B1 (en) Methods for delivering dna to muscle cells using recombinant adeno-associated virus virions
WO1997026336B1 (en) Compositions for treating anemia
KR920701238A (en) Hepatocellular factor for treating blood cell related diseases, oligonucleotides encoding them, and methods for preparing the same, pharmaceutical compositions comprising the same
AU704910B2 (en) Recombinant adenoviruses encoding glial cell neurotrophic factor (GDNF)
ZA200109151B (en) FAP-activated anti-tumor compounds.
IL86086A (en) Fusion protein with activities of interleukin-2 and gm-csf and pharmaceutical compositions containing said protein
WO1997031934A2 (en) Novel metabolizable lipopolyamines, their preparation and their use
IL125081A0 (en) Ob protein receptor and related compositions and methods
US6372890B1 (en) Water-soluble polypeptides
JPH0550273B2 (en)
EP0437487B1 (en) Targetting agents
JPH02135092A (en) Introduction of gene into cell
RU2285537C1 (en) Antitumor peptide preparation based on alpha-fetoprotein fragment, its conjugate, pharmaceutical composition and method for treatment of hormone-dependent tumors
JP3104178B2 (en) Functional polypeptide
ATE17738T1 (en) MITOGENE FROM LEUKOCYTES AND INFLAMMATED TISSUES: NATURAL LEUKOPOIETIC PROTEINS FOR THE SPECIFIC INDUCTION OF REPRODUCTION AND DIFFERENTIATION OF LEUKOCYTES; PROCESSES FOR THEIR BIOTECHNICAL PRODUCTION AND PHARMACEUTICAL COMPOSITIONS.
TW480285B (en) Enzyme for converting a precursor of a polypeptide into the active form that induces IFN-γ production, the process therefor, and the uses thereof
JPH11290073A (en) Saccharide-modified peptide derivative capable of transferring gene specifically into hepatocyte, its production and pharmaceutical composition containing the same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
COP Corrected version of pamphlet

Free format text: PAGES 1/16-16/16, DRAWINGS, REPLACED BY NEW PAGES 1/16-16/16

WWE Wipo information: entry into national phase

Ref document number: 164079

Country of ref document: IL

Ref document number: 2479309

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2004512808

Country of ref document: JP

Ref document number: 1020047014544

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2003267949

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2003748896

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 20038094266

Country of ref document: CN

B Later publication of amended claims

Effective date: 20041029

WWP Wipo information: published in national office

Ref document number: 2003748896

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10940691

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1020047014544

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 10940691

Country of ref document: US